PCDHB17P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cornea development in camera-type eye (GO:0061303)5.32882486
2neuron cell-cell adhesion (GO:0007158)4.74201025
3behavioral response to nicotine (GO:0035095)4.20580744
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.07077109
5regulation of mitotic spindle checkpoint (GO:1903504)4.07077109
6postsynaptic membrane organization (GO:0001941)3.91422264
7peptidyl-lysine dimethylation (GO:0018027)3.89810332
8olfactory bulb development (GO:0021772)3.87010569
9presynaptic membrane assembly (GO:0097105)3.86548498
10central nervous system projection neuron axonogenesis (GO:0021952)3.86504855
11positive regulation of cell cycle checkpoint (GO:1901978)3.83505808
12calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.70685122
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63167555
14sympathetic nervous system development (GO:0048485)3.62269402
15sequestering of actin monomers (GO:0042989)3.58153549
16translesion synthesis (GO:0019985)3.57290636
17presynaptic membrane organization (GO:0097090)3.52256253
18vocalization behavior (GO:0071625)3.49459599
19pyrimidine nucleobase catabolic process (GO:0006208)3.46958477
20intraciliary transport (GO:0042073)3.36874598
21histone H3-K9 methylation (GO:0051567)3.33227965
22auditory behavior (GO:0031223)3.32433548
23gamma-aminobutyric acid transport (GO:0015812)3.27416561
24head development (GO:0060322)3.26767584
25locomotory exploration behavior (GO:0035641)3.26761909
26neurotransmitter-gated ion channel clustering (GO:0072578)3.24022775
27negative regulation of transcription regulatory region DNA binding (GO:2000678)3.22534902
28negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21912061
29regulation of neuron projection regeneration (GO:0070570)3.21832282
30regulation of axon regeneration (GO:0048679)3.21832282
31positive regulation of synapse assembly (GO:0051965)3.17560585
32protein localization to synapse (GO:0035418)3.14651298
33mechanosensory behavior (GO:0007638)3.04622657
34limb bud formation (GO:0060174)3.03956169
35positive regulation of amino acid transport (GO:0051957)3.03115370
36establishment of mitochondrion localization (GO:0051654)2.98401187
37layer formation in cerebral cortex (GO:0021819)2.97121198
38central nervous system neuron axonogenesis (GO:0021955)2.95221311
39positive regulation of oligodendrocyte differentiation (GO:0048714)2.89994702
40glial cell proliferation (GO:0014009)2.85618841
41neuron recognition (GO:0008038)2.84913218
42L-serine metabolic process (GO:0006563)2.81844395
43regulation of transmission of nerve impulse (GO:0051969)2.80892043
44regulation of collateral sprouting (GO:0048670)2.78459579
45synaptic transmission, cholinergic (GO:0007271)2.76796718
46positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.72870900
47mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.72870900
48spinal cord association neuron differentiation (GO:0021527)2.72862749
49synapse assembly (GO:0007416)2.72032564
50nucleobase catabolic process (GO:0046113)2.70734030
51peptidyl-cysteine modification (GO:0018198)2.70273568
52regulation of centrosome duplication (GO:0010824)2.69503775
53retina layer formation (GO:0010842)2.66360386
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65209266
55hindbrain development (GO:0030902)2.62817142
56positive regulation of dendritic spine morphogenesis (GO:0061003)2.62546805
57regulation of synapse assembly (GO:0051963)2.60673401
58regulation of development, heterochronic (GO:0040034)2.60271114
59axonal fasciculation (GO:0007413)2.59969959
60nonmotile primary cilium assembly (GO:0035058)2.58579447
61ectodermal placode formation (GO:0060788)2.55611944
62retinal ganglion cell axon guidance (GO:0031290)2.55573866
63regulation of axon guidance (GO:1902667)2.55040738
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.54860936
65GPI anchor metabolic process (GO:0006505)2.54722337
66neural tube formation (GO:0001841)2.53590121
67DNA double-strand break processing (GO:0000729)2.52592278
68dendritic spine morphogenesis (GO:0060997)2.52541810
69glycosphingolipid biosynthetic process (GO:0006688)2.52430023
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51793279
71collecting duct development (GO:0072044)2.51687749
72negative regulation of circadian rhythm (GO:0042754)2.51588130
73vascular smooth muscle contraction (GO:0014829)2.50228153
74kinetochore organization (GO:0051383)2.50170675
75somite development (GO:0061053)2.49467685
76regulation of spindle checkpoint (GO:0090231)2.49326639
77histone H3-K9 modification (GO:0061647)2.49188625
78homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.48131900
79postreplication repair (GO:0006301)2.47463423
80generation of neurons (GO:0048699)2.44662344
81meiotic chromosome segregation (GO:0045132)2.44651816
82cilium assembly (GO:0042384)2.44470969
83C-terminal protein lipidation (GO:0006501)2.40269856
84ephrin receptor signaling pathway (GO:0048013)2.39571186
85regulation of centrosome cycle (GO:0046605)2.39483582
86synaptic vesicle endocytosis (GO:0048488)2.38638182
87cilium organization (GO:0044782)2.37993469
88protein neddylation (GO:0045116)2.36575708
89negative regulation of axonogenesis (GO:0050771)2.36450055
90mitochondrion transport along microtubule (GO:0047497)2.35600783
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.35600783
92cerebral cortex radially oriented cell migration (GO:0021799)2.35008393
93fatty acid elongation (GO:0030497)2.32795419
94exploration behavior (GO:0035640)2.32536946
95positive regulation of dendrite morphogenesis (GO:0050775)2.32003629
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.31738913
97regulation of hippo signaling (GO:0035330)2.31679704
98GPI anchor biosynthetic process (GO:0006506)2.31531348
99neuroblast proliferation (GO:0007405)2.30645387
100protein K11-linked deubiquitination (GO:0035871)2.30241659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.51760223
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.02778840
3IGF1R_20145208_ChIP-Seq_DFB_Human3.43717501
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.05034663
5TAF15_26573619_Chip-Seq_HEK293_Human2.90106151
6ZNF274_21170338_ChIP-Seq_K562_Hela2.89429398
7GBX2_23144817_ChIP-Seq_PC3_Human2.72021439
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56157831
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55458972
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28809204
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23657044
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20597454
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19833656
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12750362
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.96446776
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94372188
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.93303742
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.87807309
19EWS_26573619_Chip-Seq_HEK293_Human1.86327551
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80556835
21IRF1_19129219_ChIP-ChIP_H3396_Human1.76027103
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73786221
23RNF2_27304074_Chip-Seq_NSC_Mouse1.70988579
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65271270
25FUS_26573619_Chip-Seq_HEK293_Human1.65229288
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63808863
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.59791369
28P300_19829295_ChIP-Seq_ESCs_Human1.58408873
29REST_21632747_ChIP-Seq_MESCs_Mouse1.58041173
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56516115
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55371395
32SMAD4_21799915_ChIP-Seq_A2780_Human1.53256994
33CBP_20019798_ChIP-Seq_JUKART_Human1.48113563
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48113563
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46294144
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.45526490
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45145940
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.43142510
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42897568
40ER_23166858_ChIP-Seq_MCF-7_Human1.42197654
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41691224
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38167403
43SOX9_26525672_Chip-Seq_HEART_Mouse1.37862060
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32847925
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.32073345
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29926621
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24488561
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24361791
49RUNX2_22187159_ChIP-Seq_PCA_Human1.22228040
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.20356500
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20213937
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19941074
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18723268
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17854485
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.14625929
56STAT3_23295773_ChIP-Seq_U87_Human1.13736083
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.13575300
58ELK1_19687146_ChIP-ChIP_HELA_Human1.13166506
59JUN_21703547_ChIP-Seq_K562_Human1.12872125
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11989770
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11301358
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10957713
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10292716
64VDR_22108803_ChIP-Seq_LS180_Human1.10284802
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10228640
66TBX3_20139965_ChIP-Seq_MESCs_Mouse1.09835400
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09330389
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09330389
69AR_25329375_ChIP-Seq_VCAP_Human1.08414318
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08303462
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07774082
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06325070
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05267107
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03860524
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03149683
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03149683
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03007462
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02849109
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01883397
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.01399813
81POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.01282371
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00839864
83POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00339262
84TCF4_23295773_ChIP-Seq_U87_Human1.00234622
85EZH2_27294783_Chip-Seq_ESCs_Mouse0.99127524
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98080221
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97890189
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.97211896
89P53_22387025_ChIP-Seq_ESCs_Mouse0.96214355
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94937253
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94193522
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.93173940
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.92730013
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90849139
95AHR_22903824_ChIP-Seq_MCF-7_Human0.89721365
96REST_19997604_ChIP-ChIP_NEURONS_Mouse0.89206948
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89092990
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88884861
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88748336
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87884385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity2.76534779
2MP0005248_abnormal_Harderian_gland2.68687117
3MP0003880_abnormal_central_pattern2.57891788
4MP0000778_abnormal_nervous_system2.48866763
5MP0001529_abnormal_vocalization2.34968008
6MP0005423_abnormal_somatic_nervous2.30209301
7MP0002234_abnormal_pharynx_morphology2.28448914
8MP0002736_abnormal_nociception_after2.16913021
9MP0002254_reproductive_system_inflammat2.16151878
10MP0002653_abnormal_ependyma_morphology2.12356838
11MP0002638_abnormal_pupillary_reflex1.98411329
12MP0001968_abnormal_touch/_nociception1.89982547
13MP0004270_analgesia1.89474645
14MP0004782_abnormal_surfactant_physiolog1.88406602
15MP0002090_abnormal_vision1.87739811
16MP0002751_abnormal_autonomic_nervous1.82303922
17MP0005171_absent_coat_pigmentation1.75341836
18MP0002909_abnormal_adrenal_gland1.74104813
19MP0001984_abnormal_olfaction1.71835833
20MP0001293_anophthalmia1.66073191
21MP0006276_abnormal_autonomic_nervous1.62765326
22MP0000631_abnormal_neuroendocrine_gland1.62750168
23MP0003136_yellow_coat_color1.62028676
24MP0000427_abnormal_hair_cycle1.57988550
25MP0000537_abnormal_urethra_morphology1.57710203
26MP0006072_abnormal_retinal_apoptosis1.55009220
27MP0002557_abnormal_social/conspecific_i1.54799668
28MP0002735_abnormal_chemical_nociception1.53513706
29MP0001486_abnormal_startle_reflex1.53482969
30MP0000049_abnormal_middle_ear1.52103718
31MP0002160_abnormal_reproductive_system1.51333023
32MP0002734_abnormal_mechanical_nocicepti1.51319959
33MP0003635_abnormal_synaptic_transmissio1.51024607
34MP0001346_abnormal_lacrimal_gland1.48090816
35MP0010030_abnormal_orbit_morphology1.47817800
36MP0005187_abnormal_penis_morphology1.47382538
37MP0005646_abnormal_pituitary_gland1.45522731
38MP0004742_abnormal_vestibular_system1.44769481
39MP0000647_abnormal_sebaceous_gland1.43936680
40MP0003937_abnormal_limbs/digits/tail_de1.42764129
41MP0004133_heterotaxia1.40841350
42MP0002063_abnormal_learning/memory/cond1.38289029
43MP0009046_muscle_twitch1.32263121
44MP0003787_abnormal_imprinting1.29399301
45MP0003890_abnormal_embryonic-extraembry1.27488963
46MP0002882_abnormal_neuron_morphology1.24917293
47MP0002067_abnormal_sensory_capabilities1.24150584
48MP0000751_myopathy1.24048175
49MP0002697_abnormal_eye_size1.22860140
50MP0002152_abnormal_brain_morphology1.22650206
51MP0005551_abnormal_eye_electrophysiolog1.22177968
52MP0001299_abnormal_eye_distance/1.21899203
53MP0003861_abnormal_nervous_system1.21818737
54MP0008789_abnormal_olfactory_epithelium1.21658770
55MP0002572_abnormal_emotion/affect_behav1.20703736
56MP0010386_abnormal_urinary_bladder1.20408240
57MP0002184_abnormal_innervation1.19980527
58MP0002272_abnormal_nervous_system1.17484250
59MP0004811_abnormal_neuron_physiology1.13574436
60MP0005499_abnormal_olfactory_system1.13235895
61MP0005394_taste/olfaction_phenotype1.13235895
62MP0006292_abnormal_olfactory_placode1.12892775
63MP0005253_abnormal_eye_physiology1.12878484
64MP0003122_maternal_imprinting1.11377132
65MP0009745_abnormal_behavioral_response1.11370984
66MP0005389_reproductive_system_phenotype1.11007357
67MP0000569_abnormal_digit_pigmentation1.09064931
68MP0002233_abnormal_nose_morphology1.08509560
69MP0002752_abnormal_somatic_nervous1.07859816
70MP0000955_abnormal_spinal_cord1.07806324
71MP0001286_abnormal_eye_development1.07249020
72MP0000579_abnormal_nail_morphology1.06611195
73MP0005645_abnormal_hypothalamus_physiol1.06603158
74MP0004142_abnormal_muscle_tone1.05999301
75MP0008932_abnormal_embryonic_tissue1.05244408
76MP0003119_abnormal_digestive_system1.05014014
77MP0001177_atelectasis1.04096628
78MP0003115_abnormal_respiratory_system1.03763754
79MP0003755_abnormal_palate_morphology1.03531425
80MP0003942_abnormal_urinary_system1.02555650
81MP0002092_abnormal_eye_morphology1.00221729
82MP0003221_abnormal_cardiomyocyte_apopto0.99353503
83MP0002282_abnormal_trachea_morphology0.99328878
84MP0005386_behavior/neurological_phenoty0.97406743
85MP0004924_abnormal_behavior0.97406743
86MP0000026_abnormal_inner_ear0.97181527
87MP0005391_vision/eye_phenotype0.97103214
88MP0001963_abnormal_hearing_physiology0.95780451
89MP0001919_abnormal_reproductive_system0.95692241
90MP0003567_abnormal_fetal_cardiomyocyte0.95349202
91MP0001970_abnormal_pain_threshold0.91273571
92MP0005195_abnormal_posterior_eye0.89098671
93MP0004147_increased_porphyrin_level0.87504556
94MP0002064_seizures0.84407213
95MP0003634_abnormal_glial_cell0.84340171
96MP0004885_abnormal_endolymph0.83002354
97MP0003385_abnormal_body_wall0.82223454
98MP0001879_abnormal_lymphatic_vessel0.81418355
99MP0003693_abnormal_embryo_hatching0.80563242
100MP0003941_abnormal_skin_development0.77583406

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)4.39830337
2Chronic hepatic failure (HP:0100626)3.79401978
3True hermaphroditism (HP:0010459)3.67680296
4Gait imbalance (HP:0002141)3.10739196
5Optic nerve hypoplasia (HP:0000609)3.05415493
6Vitreoretinal degeneration (HP:0000655)2.97693929
7Occipital encephalocele (HP:0002085)2.92984964
8Nephronophthisis (HP:0000090)2.92652345
9Congenital primary aphakia (HP:0007707)2.89406264
10Abnormality of midbrain morphology (HP:0002418)2.82905755
11Molar tooth sign on MRI (HP:0002419)2.82905755
12Termporal pattern (HP:0011008)2.79443835
13Insidious onset (HP:0003587)2.79443835
14Pancreatic cysts (HP:0001737)2.73002201
15Medial flaring of the eyebrow (HP:0010747)2.72669687
16Pancreatic fibrosis (HP:0100732)2.72401889
17Increased hepatocellular lipid droplets (HP:0006565)2.70493519
18Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.67773173
19Nephrogenic diabetes insipidus (HP:0009806)2.56160861
20Severe Myopia (HP:0011003)2.54992468
21Abnormal biliary tract physiology (HP:0012439)2.54659767
22Bile duct proliferation (HP:0001408)2.54659767
23Concave nail (HP:0001598)2.53013538
24Poor coordination (HP:0002370)2.47272126
25Oligodactyly (hands) (HP:0001180)2.45640864
26Lipid accumulation in hepatocytes (HP:0006561)2.42320194
27Bifid tongue (HP:0010297)2.40635717
28Cystic liver disease (HP:0006706)2.32199283
29Vaginal atresia (HP:0000148)2.31232128
30Epileptic encephalopathy (HP:0200134)2.29725248
31Absent septum pellucidum (HP:0001331)2.26857955
32Atonic seizures (HP:0010819)2.25914722
33Genital tract atresia (HP:0001827)2.19595895
34Abnormality of the septum pellucidum (HP:0007375)2.15383476
35Focal seizures (HP:0007359)2.14993431
36Hyperventilation (HP:0002883)2.14604244
37Dyschromatopsia (HP:0007641)2.09993939
38Broad nasal tip (HP:0000455)2.09184091
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.08423056
40Abnormality of the intervertebral disk (HP:0005108)2.07025731
41Abnormality of the renal medulla (HP:0100957)2.05333635
42High anterior hairline (HP:0009890)2.05311345
43Split foot (HP:0001839)2.04371236
44Postaxial hand polydactyly (HP:0001162)2.03497203
45Amyotrophic lateral sclerosis (HP:0007354)2.00339887
46Hepatocellular necrosis (HP:0001404)1.99447353
47Uterine leiomyosarcoma (HP:0002891)1.99410258
48Leiomyosarcoma (HP:0100243)1.99410258
49Supernumerary spleens (HP:0009799)1.99296864
50Sclerocornea (HP:0000647)1.98367974
51Aganglionic megacolon (HP:0002251)1.96018475
52Astigmatism (HP:0000483)1.95755364
53Specific learning disability (HP:0001328)1.94908234
54Rib fusion (HP:0000902)1.94141286
55Focal motor seizures (HP:0011153)1.91315610
56Postaxial foot polydactyly (HP:0001830)1.90568449
57Hypoplastic pelvis (HP:0008839)1.90402086
58Hyperglycinemia (HP:0002154)1.89920421
59Cerebellar dysplasia (HP:0007033)1.89573040
60Retinal dysplasia (HP:0007973)1.87447972
61Meckel diverticulum (HP:0002245)1.86725684
62Partial agenesis of the corpus callosum (HP:0001338)1.86329519
63Tubulointerstitial nephritis (HP:0001970)1.86264781
64Atrophy/Degeneration involving motor neurons (HP:0007373)1.86157037
65Abnormality of the ileum (HP:0001549)1.85309580
66Oligodactyly (HP:0012165)1.84272684
67Broad foot (HP:0001769)1.82821962
68Impaired vibration sensation in the lower limbs (HP:0002166)1.82294726
69Transitional cell carcinoma of the bladder (HP:0006740)1.81626209
70Preaxial hand polydactyly (HP:0001177)1.81391197
71Abnormality of the corticospinal tract (HP:0002492)1.78599500
72Disproportionate short-trunk short stature (HP:0003521)1.78413887
73Mitochondrial inheritance (HP:0001427)1.78048178
74Hypsarrhythmia (HP:0002521)1.73786293
75Broad-based gait (HP:0002136)1.73707368
76Anencephaly (HP:0002323)1.72951301
77Narrow forehead (HP:0000341)1.72581466
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.71924222
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69496173
80Degeneration of the lateral corticospinal tracts (HP:0002314)1.69496173
81Abnormality of the sella turcica (HP:0002679)1.68485749
82Renal Fanconi syndrome (HP:0001994)1.68179654
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68007375
84Congenital hepatic fibrosis (HP:0002612)1.67216578
85Unilateral renal agenesis (HP:0000122)1.66983274
86Amblyopia (HP:0000646)1.66653304
87Abnormality of the lower motor neuron (HP:0002366)1.66225283
88Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66222688
89EEG with generalized epileptiform discharges (HP:0011198)1.65165022
90Pachygyria (HP:0001302)1.64986664
91Epileptiform EEG discharges (HP:0011182)1.64686029
92Intestinal atresia (HP:0011100)1.64337406
93Abnormality of the phalanges of the 5th finger (HP:0004213)1.64003323
94Growth hormone deficiency (HP:0000824)1.63150731
95Patellar aplasia (HP:0006443)1.62023626
96Spina bifida occulta (HP:0003298)1.61305342
97Lissencephaly (HP:0001339)1.61277317
98Short philtrum (HP:0000322)1.60202693
99Aplasia/Hypoplasia of the lens (HP:0008063)1.59842514
100Acute encephalopathy (HP:0006846)1.58153772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.85475009
2BCR4.08645492
3ERBB33.61240319
4MARK13.15699384
5TRIM282.70333668
6CAMK1D2.65397951
7DYRK32.56929245
8WNK32.27484576
9LIMK12.19993311
10EPHA42.10400388
11BCKDK1.98607586
12MAP3K41.94013603
13TESK11.90447359
14CAMKK21.87919513
15DYRK21.83400700
16CSNK1G21.78500569
17CAMK1G1.78008980
18CSNK1G31.75080444
19CSNK1A1L1.62697395
20PBK1.61203167
21MINK11.57261720
22CSNK1G11.57114522
23NTRK21.56551923
24MKNK11.47259453
25MAP2K71.45216310
26SRPK11.42914629
27LATS11.42457037
28ERBB41.41209796
29EPHB21.39476533
30MAPK131.32957138
31SIK31.32864977
32ZAK1.24179521
33BRD41.24035154
34PINK11.19279485
35MKNK21.17479016
36CDC71.14074036
37CAMK41.13271137
38NEK11.11644628
39ERBB21.11228523
40PLK21.08697356
41UHMK11.05718133
42RPS6KA41.02263174
43CDK191.00106135
44STK38L0.99529317
45DYRK1B0.98818172
46FER0.98514707
47CAMK2B0.93331800
48NTRK30.91133994
49WEE10.89650854
50DYRK1A0.86929239
51KSR10.86597435
52NUAK10.86219326
53PRKCE0.82874103
54CAMKK10.81512892
55PKN10.77539310
56PAK40.73370708
57NEK90.67381340
58PAK30.66732318
59PDGFRA0.65404056
60NTRK10.64868521
61CCNB10.63539166
62STK160.62404847
63CAMK10.59488510
64PRKCG0.59099399
65CAMK2A0.58714034
66CDK30.56974011
67WNK40.56623330
68CDK140.55417070
69PLK10.55150517
70AKT20.54689118
71PRKD30.52508328
72CAMK2G0.52393598
73MAP4K20.52000777
74MET0.50413893
75PAK60.49557248
76CAMK2D0.47060722
77CSNK1D0.46374153
78DMPK0.44161705
79MARK20.42270642
80BMPR20.42131561
81CDK180.40644532
82PIK3CA0.40187234
83CDK60.39886912
84ROCK20.39611383
85CDK80.38657423
86CDK50.34736619
87CSNK1E0.34320687
88ATM0.32731234
89ATR0.32646789
90CDK11A0.32361461
91PRKCI0.31280012
92TESK20.30489638
93ADRBK20.30215740
94CDK150.29277634
95SGK2230.29186266
96SGK4940.29186266
97EIF2AK10.26868707
98CSNK1A10.25639325
99STK380.23382186
100CDK90.23080032

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.43202013
2Nicotine addiction_Homo sapiens_hsa050333.05414275
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95716204
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.94072117
5Fatty acid elongation_Homo sapiens_hsa000622.64059818
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48555380
7Fanconi anemia pathway_Homo sapiens_hsa034602.20220614
8Steroid biosynthesis_Homo sapiens_hsa001002.12067846
9Homologous recombination_Homo sapiens_hsa034402.06613739
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03516492
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90772111
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81839073
13Basal cell carcinoma_Homo sapiens_hsa052171.79499028
14Axon guidance_Homo sapiens_hsa043601.79113796
15GABAergic synapse_Homo sapiens_hsa047271.70392270
16Butanoate metabolism_Homo sapiens_hsa006501.67942767
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62882057
18Hedgehog signaling pathway_Homo sapiens_hsa043401.58095754
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48427803
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44126793
21Hippo signaling pathway_Homo sapiens_hsa043901.43129377
22Morphine addiction_Homo sapiens_hsa050321.39579697
23Circadian entrainment_Homo sapiens_hsa047131.36079797
24Propanoate metabolism_Homo sapiens_hsa006401.35784183
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28817413
26Dopaminergic synapse_Homo sapiens_hsa047281.26413086
27Nucleotide excision repair_Homo sapiens_hsa034201.25910059
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24726576
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.22574363
30Basal transcription factors_Homo sapiens_hsa030221.22342635
31Glutamatergic synapse_Homo sapiens_hsa047241.19937320
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16841078
33Taste transduction_Homo sapiens_hsa047421.15081752
34Melanogenesis_Homo sapiens_hsa049161.06941898
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05378776
36Fatty acid metabolism_Homo sapiens_hsa012121.03588615
37Lysine degradation_Homo sapiens_hsa003101.02726631
38mRNA surveillance pathway_Homo sapiens_hsa030151.00240133
39Non-homologous end-joining_Homo sapiens_hsa034500.98597789
40RNA degradation_Homo sapiens_hsa030180.95229683
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93404681
42Sulfur relay system_Homo sapiens_hsa041220.93235542
43Cholinergic synapse_Homo sapiens_hsa047250.91977089
44Mismatch repair_Homo sapiens_hsa034300.91953069
45Oocyte meiosis_Homo sapiens_hsa041140.86361244
46Long-term depression_Homo sapiens_hsa047300.85957480
47p53 signaling pathway_Homo sapiens_hsa041150.85368436
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83518113
49Cardiac muscle contraction_Homo sapiens_hsa042600.83476570
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81571439
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80602146
52Notch signaling pathway_Homo sapiens_hsa043300.79711950
53Alcoholism_Homo sapiens_hsa050340.78014017
54Parkinsons disease_Homo sapiens_hsa050120.74368223
55Wnt signaling pathway_Homo sapiens_hsa043100.72177139
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70705239
57Peroxisome_Homo sapiens_hsa041460.69532389
58Huntingtons disease_Homo sapiens_hsa050160.69196736
59Cocaine addiction_Homo sapiens_hsa050300.67289990
60Amphetamine addiction_Homo sapiens_hsa050310.63794291
61Adherens junction_Homo sapiens_hsa045200.63762461
62TGF-beta signaling pathway_Homo sapiens_hsa043500.63235676
63Cell cycle_Homo sapiens_hsa041100.62807278
64Colorectal cancer_Homo sapiens_hsa052100.60426709
65Serotonergic synapse_Homo sapiens_hsa047260.60277578
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57593962
67Spliceosome_Homo sapiens_hsa030400.57373379
68Biosynthesis of amino acids_Homo sapiens_hsa012300.56967105
69Phototransduction_Homo sapiens_hsa047440.56456613
70Thyroid cancer_Homo sapiens_hsa052160.54638802
71Tight junction_Homo sapiens_hsa045300.53939374
72Base excision repair_Homo sapiens_hsa034100.52855341
73Sphingolipid metabolism_Homo sapiens_hsa006000.52790147
74RNA transport_Homo sapiens_hsa030130.52740794
75Nitrogen metabolism_Homo sapiens_hsa009100.52652382
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.52096111
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51975366
78Oxidative phosphorylation_Homo sapiens_hsa001900.51340499
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51081174
80MicroRNAs in cancer_Homo sapiens_hsa052060.49148209
81Gap junction_Homo sapiens_hsa045400.48651071
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47448757
83Circadian rhythm_Homo sapiens_hsa047100.45908060
84Synaptic vesicle cycle_Homo sapiens_hsa047210.45519877
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44280943
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44128235
87Ras signaling pathway_Homo sapiens_hsa040140.43163915
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42273804
89beta-Alanine metabolism_Homo sapiens_hsa004100.41514305
90Insulin secretion_Homo sapiens_hsa049110.40362381
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40285133
92Olfactory transduction_Homo sapiens_hsa047400.40213479
93Pathways in cancer_Homo sapiens_hsa052000.39528879
94Inositol phosphate metabolism_Homo sapiens_hsa005620.39493987
95Alzheimers disease_Homo sapiens_hsa050100.39219260
96Fatty acid degradation_Homo sapiens_hsa000710.39107242
97Metabolic pathways_Homo sapiens_hsa011000.38583091
98Arginine and proline metabolism_Homo sapiens_hsa003300.35476797
99Long-term potentiation_Homo sapiens_hsa047200.35279063
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35060730

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