PCDHB13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.59567980
2neuron cell-cell adhesion (GO:0007158)4.52416364
3startle response (GO:0001964)4.42965311
4ionotropic glutamate receptor signaling pathway (GO:0035235)4.35640505
5vocalization behavior (GO:0071625)4.34228922
6regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33256918
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33004448
8presynaptic membrane organization (GO:0097090)4.20785094
9synaptic vesicle exocytosis (GO:0016079)4.19368786
10glutamate receptor signaling pathway (GO:0007215)4.18100074
11synaptic transmission, glutamatergic (GO:0035249)4.16376503
12protein localization to synapse (GO:0035418)4.13111306
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10939817
14L-fucose catabolic process (GO:0042355)4.08958247
15fucose catabolic process (GO:0019317)4.08958247
16L-fucose metabolic process (GO:0042354)4.08958247
17postsynaptic membrane organization (GO:0001941)4.07942484
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05202812
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.04796100
20neurotransmitter-gated ion channel clustering (GO:0072578)4.04493972
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.02971391
22regulation of glutamate receptor signaling pathway (GO:1900449)4.00581860
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.96970046
24neuron-neuron synaptic transmission (GO:0007270)3.87782144
25negative regulation of telomere maintenance (GO:0032205)3.83085624
26glutamate secretion (GO:0014047)3.78970719
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.74508056
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65228444
29neuronal action potential propagation (GO:0019227)3.63553798
30pyrimidine nucleobase catabolic process (GO:0006208)3.61825322
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.51563417
32gamma-aminobutyric acid transport (GO:0015812)3.50918577
33epithelial cilium movement (GO:0003351)3.50482200
34cerebral cortex radially oriented cell migration (GO:0021799)3.45290062
35cornea development in camera-type eye (GO:0061303)3.42298115
36cAMP catabolic process (GO:0006198)3.40440275
37regulation of synaptic vesicle exocytosis (GO:2000300)3.38874326
38platelet dense granule organization (GO:0060155)3.35092822
39neuron recognition (GO:0008038)3.34928844
40detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.32874675
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28294626
42regulation of synapse maturation (GO:0090128)3.23708402
43cyclic nucleotide catabolic process (GO:0009214)3.22794313
44transmission of nerve impulse (GO:0019226)3.22762538
45auditory behavior (GO:0031223)3.22069505
46retinal cone cell development (GO:0046549)3.20464658
47response to auditory stimulus (GO:0010996)3.18022633
48positive regulation of synapse assembly (GO:0051965)3.15124096
49regulation of synaptic vesicle transport (GO:1902803)3.14214319
50nucleobase catabolic process (GO:0046113)3.13918846
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.09875419
52regulation of glucokinase activity (GO:0033131)3.09694983
53regulation of hexokinase activity (GO:1903299)3.09694983
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08895137
55indolalkylamine metabolic process (GO:0006586)3.08651233
56long-term memory (GO:0007616)3.07349065
57protein complex biogenesis (GO:0070271)3.07216747
58mechanosensory behavior (GO:0007638)3.07062894
59long-chain fatty acid biosynthetic process (GO:0042759)3.04118190
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03761020
61axonal fasciculation (GO:0007413)3.01808623
62opioid receptor signaling pathway (GO:0038003)3.00221510
63neuromuscular synaptic transmission (GO:0007274)2.99375710
64mitochondrial respiratory chain complex I assembly (GO:0032981)2.99173099
65NADH dehydrogenase complex assembly (GO:0010257)2.99173099
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99173099
67regulation of postsynaptic membrane potential (GO:0060078)2.97761560
68regulation of neurotransmitter secretion (GO:0046928)2.96798672
69water-soluble vitamin biosynthetic process (GO:0042364)2.96468692
70regulation of telomere maintenance (GO:0032204)2.96219485
71cerebellar granule cell differentiation (GO:0021707)2.95989784
72cilium movement (GO:0003341)2.93567229
73primary amino compound metabolic process (GO:1901160)2.93437141
74positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93304300
75central nervous system projection neuron axonogenesis (GO:0021952)2.92829648
76* synapse assembly (GO:0007416)2.92779048
77regulation of synapse assembly (GO:0051963)2.92664438
78calcium ion import (GO:0070509)2.92555791
79neurotransmitter secretion (GO:0007269)2.91087266
80long-term synaptic potentiation (GO:0060291)2.90899996
81axoneme assembly (GO:0035082)2.90870307
82dendrite development (GO:0016358)2.90646978
83cilium morphogenesis (GO:0060271)2.90561191
84nonmotile primary cilium assembly (GO:0035058)2.90069701
85kidney morphogenesis (GO:0060993)2.88234021
86protein polyglutamylation (GO:0018095)2.87810125
87regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87800959
88neural tube formation (GO:0001841)2.87490803
89positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87288356
90membrane depolarization during action potential (GO:0086010)2.85943121
91detection of light stimulus involved in sensory perception (GO:0050962)2.85838678
92detection of light stimulus involved in visual perception (GO:0050908)2.85838678
93regulation of vesicle fusion (GO:0031338)2.83568883
94somite development (GO:0061053)2.83500379
95limb bud formation (GO:0060174)2.81393337
96serotonin metabolic process (GO:0042428)2.80593164
97negative regulation of neurotransmitter transport (GO:0051589)2.80529169
98locomotory exploration behavior (GO:0035641)2.79337246
99synaptic vesicle endocytosis (GO:0048488)2.79187462
100regulation of neuronal synaptic plasticity (GO:0048168)2.79136433
101mitochondrial respiratory chain complex assembly (GO:0033108)2.78938245
102regulation of voltage-gated calcium channel activity (GO:1901385)2.76855720
103regulation of synaptic transmission, GABAergic (GO:0032228)2.76751734
104regulation of neurotransmitter transport (GO:0051588)2.76605823
105neuronal action potential (GO:0019228)2.76247912
106regulation of action potential (GO:0098900)2.75532671
107dendritic spine morphogenesis (GO:0060997)2.73492081
108photoreceptor cell development (GO:0042461)2.73450612
109membrane depolarization (GO:0051899)2.72797898
110cilium organization (GO:0044782)2.72467826
111indole-containing compound catabolic process (GO:0042436)2.70686041
112indolalkylamine catabolic process (GO:0046218)2.70686041
113tryptophan catabolic process (GO:0006569)2.70686041
114cochlea development (GO:0090102)2.70387388
115behavioral response to ethanol (GO:0048149)2.70115576
116nephron epithelium morphogenesis (GO:0072088)2.69959602
117nephron tubule morphogenesis (GO:0072078)2.69959602
118negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68152741
119inner ear receptor stereocilium organization (GO:0060122)2.67742046
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67649124
121behavioral response to nicotine (GO:0035095)2.67327812
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67292219
123cilium assembly (GO:0042384)2.66866573
124cerebellar Purkinje cell differentiation (GO:0021702)2.66817358
125cranial nerve structural organization (GO:0021604)2.66079295
126neurotransmitter transport (GO:0006836)2.65513590
127righting reflex (GO:0060013)2.65488347
128positive regulation of membrane potential (GO:0045838)2.65383392
129protein-cofactor linkage (GO:0018065)2.65268372
130central nervous system neuron axonogenesis (GO:0021955)2.65002405
131L-amino acid import (GO:0043092)2.64955237
132learning (GO:0007612)2.64938352
133regulation of respiratory system process (GO:0044065)2.64657058
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.64473612
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64360557
136* synaptic transmission (GO:0007268)2.63284045
137neuronal ion channel clustering (GO:0045161)2.63132916
138behavioral response to cocaine (GO:0048148)2.62785122
139adult behavior (GO:0030534)2.62122060
140positive regulation of neurotransmitter transport (GO:0051590)2.60803807
141positive regulation of neurotransmitter secretion (GO:0001956)2.60555445
142urinary tract smooth muscle contraction (GO:0014848)2.60499690
143response to pheromone (GO:0019236)2.59352066
144kynurenine metabolic process (GO:0070189)2.58117354
145retinal ganglion cell axon guidance (GO:0031290)2.57845454
146reflex (GO:0060004)2.56525274
147intraciliary transport (GO:0042073)2.56386172
148piRNA metabolic process (GO:0034587)2.56104929
149positive regulation of synaptic transmission (GO:0050806)2.56094066
150indole-containing compound metabolic process (GO:0042430)2.55845808
151regulation of cilium movement (GO:0003352)2.55714661
152regulation of respiratory gaseous exchange (GO:0043576)2.55253116
153tryptophan metabolic process (GO:0006568)2.55181045
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54498138
155rhodopsin mediated signaling pathway (GO:0016056)2.54061075
156regulation of hippo signaling (GO:0035330)2.53028119
157cellular ketone body metabolic process (GO:0046950)2.52861963
158response to histamine (GO:0034776)2.52774194
159synaptic transmission, cholinergic (GO:0007271)2.52147397
160regulation of synaptic plasticity (GO:0048167)2.52092354
161regulation of synapse organization (GO:0050807)2.51711053
162respiratory chain complex IV assembly (GO:0008535)2.51256379
163ubiquinone metabolic process (GO:0006743)2.49877229
164ubiquinone biosynthetic process (GO:0006744)2.49868803
165eye photoreceptor cell development (GO:0042462)2.49512943
166DNA deamination (GO:0045006)2.46528307
167auditory receptor cell stereocilium organization (GO:0060088)2.44981673
168phasic smooth muscle contraction (GO:0014821)2.44434613
169replication fork processing (GO:0031297)2.43987889
170preassembly of GPI anchor in ER membrane (GO:0016254)2.43436990
171C4-dicarboxylate transport (GO:0015740)2.43246224
172glycerophospholipid catabolic process (GO:0046475)2.42003079
173hindbrain development (GO:0030902)2.41104004
174protein localization to cilium (GO:0061512)2.40572770
175sulfation (GO:0051923)2.38929341
176smoothened signaling pathway (GO:0007224)2.38159349
177cell proliferation in forebrain (GO:0021846)2.36572630
178mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36038874
179photoreceptor cell maintenance (GO:0045494)2.34342743
180atrial cardiac muscle cell action potential (GO:0086014)2.34196886
181somite rostral/caudal axis specification (GO:0032525)2.32133379
182negative regulation of mast cell activation (GO:0033004)2.32036155
183artery development (GO:0060840)2.30599367
184detection of mechanical stimulus involved in sensory perception (GO:0050974)2.29229379
185action potential (GO:0001508)2.28516459
186energy coupled proton transport, down electrochemical gradient (GO:0015985)2.28437700
187ATP synthesis coupled proton transport (GO:0015986)2.28437700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79615227
2GBX2_23144817_ChIP-Seq_PC3_Human4.63740032
3ZNF274_21170338_ChIP-Seq_K562_Hela3.84389993
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80367431
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78901460
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76108899
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.61087129
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.47547245
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45953242
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42253057
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38059477
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26138972
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24300132
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24300132
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19786502
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14259300
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12974955
18TAF15_26573619_Chip-Seq_HEK293_Human2.11033496
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09820267
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05842417
21EWS_26573619_Chip-Seq_HEK293_Human2.05012467
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04818294
23REST_21632747_ChIP-Seq_MESCs_Mouse2.04776531
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.04021100
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01649569
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00509482
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.98450049
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.96957771
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96448049
30P300_19829295_ChIP-Seq_ESCs_Human1.92964346
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90718767
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89360207
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87794538
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86858280
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82711547
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82396552
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82293663
38SMAD4_21799915_ChIP-Seq_A2780_Human1.78886729
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.76297583
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.74138775
41DROSHA_22980978_ChIP-Seq_HELA_Human1.72632648
42AR_21572438_ChIP-Seq_LNCaP_Human1.69246262
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.68871485
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66746105
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.66571154
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66550652
47IGF1R_20145208_ChIP-Seq_DFB_Human1.60907123
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57420588
49FUS_26573619_Chip-Seq_HEK293_Human1.53816628
50RNF2_27304074_Chip-Seq_NSC_Mouse1.51755372
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.51624733
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47319936
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46857144
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46459003
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.45893932
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45043405
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44063778
58VDR_22108803_ChIP-Seq_LS180_Human1.43550973
59ER_23166858_ChIP-Seq_MCF-7_Human1.42612071
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41587604
61CBP_20019798_ChIP-Seq_JUKART_Human1.40259009
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40259009
63TP53_22573176_ChIP-Seq_HFKS_Human1.39156234
64STAT3_23295773_ChIP-Seq_U87_Human1.38723178
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38580063
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38492813
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38331504
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38239823
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37700639
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36824769
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35723890
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.35384799
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.35209088
74AR_25329375_ChIP-Seq_VCAP_Human1.34757184
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31443060
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31357116
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30238549
78MYC_18940864_ChIP-ChIP_HL60_Human1.29502181
79TCF4_22108803_ChIP-Seq_LS180_Human1.28926289
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28075643
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.27374866
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26613998
83TCF4_23295773_ChIP-Seq_U87_Human1.26478552
84P53_22387025_ChIP-Seq_ESCs_Mouse1.26105592
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24836404
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24739348
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.23756105
88IRF1_19129219_ChIP-ChIP_H3396_Human1.22982206
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.21628227
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21377423
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21377423
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.21013272
93NANOG_19829295_ChIP-Seq_ESCs_Human1.19877411
94SOX2_19829295_ChIP-Seq_ESCs_Human1.19877411
95RARB_27405468_Chip-Seq_BRAIN_Mouse1.18075157
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.18009362
97EST1_17652178_ChIP-ChIP_JURKAT_Human1.17959943
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17875089
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16654822
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16617236
101RUNX2_22187159_ChIP-Seq_PCA_Human1.16428402
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15895168
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.15370213
104P300_18555785_Chip-Seq_ESCs_Mouse1.14881194
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14661836
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14591949
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.13710106
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13625296
109TP53_18474530_ChIP-ChIP_U2OS_Human1.12997336
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.12062678
111EZH2_27294783_Chip-Seq_NPCs_Mouse1.10544981
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10541975
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10053850
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10033623
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.09612028
116AHR_22903824_ChIP-Seq_MCF-7_Human1.09132274
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.09001035
118BCAT_22108803_ChIP-Seq_LS180_Human1.08439317
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08429876
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.08323187
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08323187
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.07888547
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07173901
124NMYC_18555785_Chip-Seq_ESCs_Mouse1.07102317
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05252461
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.04612444
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04394839
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04175624
129KDM2B_26808549_Chip-Seq_REH_Human1.03578749
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03117158
131GATA3_21878914_ChIP-Seq_MCF-7_Human1.02936706
132TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99644703
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99434936
134AR_20517297_ChIP-Seq_VCAP_Human0.99049812
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98966455
136* NCOR_22424771_ChIP-Seq_293T_Human0.97408533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.93222905
2MP0004859_abnormal_synaptic_plasticity3.70776143
3MP0003635_abnormal_synaptic_transmissio3.06944940
4MP0001968_abnormal_touch/_nociception2.97592814
5MP0009745_abnormal_behavioral_response2.89074916
6MP0004270_analgesia2.77459595
7MP0001188_hyperpigmentation2.75678061
8MP0002736_abnormal_nociception_after2.71608561
9MP0001486_abnormal_startle_reflex2.69569693
10MP0005646_abnormal_pituitary_gland2.65010132
11MP0002063_abnormal_learning/memory/cond2.61647680
12MP0002064_seizures2.60208564
13MP0003787_abnormal_imprinting2.57995407
14MP0003195_calcinosis2.53561253
15MP0009046_muscle_twitch2.52080504
16MP0002734_abnormal_mechanical_nocicepti2.45265419
17MP0002572_abnormal_emotion/affect_behav2.44828662
18MP0005171_absent_coat_pigmentation2.33664356
19MP0002272_abnormal_nervous_system2.33019472
20MP0005645_abnormal_hypothalamus_physiol2.31881186
21MP0002735_abnormal_chemical_nociception2.22474551
22MP0005423_abnormal_somatic_nervous2.21968264
23MP0001502_abnormal_circadian_rhythm2.13328874
24MP0010386_abnormal_urinary_bladder2.09096993
25MP0000566_synostosis2.01954189
26MP0000569_abnormal_digit_pigmentation2.01218492
27MP0002067_abnormal_sensory_capabilities1.97767582
28MP0006276_abnormal_autonomic_nervous1.97155695
29MP0004133_heterotaxia1.95964906
30MP0001529_abnormal_vocalization1.89479993
31MP0001501_abnormal_sleep_pattern1.84721135
32MP0000778_abnormal_nervous_system1.81221231
33MP0002837_dystrophic_cardiac_calcinosis1.79922709
34MP0002638_abnormal_pupillary_reflex1.79416760
35MP0004742_abnormal_vestibular_system1.77492597
36MP0002557_abnormal_social/conspecific_i1.77294051
37MP0006292_abnormal_olfactory_placode1.73510377
38MP0001440_abnormal_grooming_behavior1.73098400
39MP0001984_abnormal_olfaction1.72324703
40MP0005551_abnormal_eye_electrophysiolog1.70136032
41MP0002653_abnormal_ependyma_morphology1.67708539
42MP0005386_behavior/neurological_phenoty1.66997440
43MP0004924_abnormal_behavior1.66997440
44MP0000427_abnormal_hair_cycle1.64481150
45MP0001970_abnormal_pain_threshold1.60225460
46MP0001346_abnormal_lacrimal_gland1.56966769
47MP0002822_catalepsy1.53435773
48MP0002733_abnormal_thermal_nociception1.53245653
49MP0003890_abnormal_embryonic-extraembry1.51769836
50MP0002184_abnormal_innervation1.51549458
51MP0002876_abnormal_thyroid_physiology1.51121585
52MP0003879_abnormal_hair_cell1.50329253
53MP0003122_maternal_imprinting1.47141924
54MP0000372_irregular_coat_pigmentation1.44420649
55MP0009780_abnormal_chondrocyte_physiolo1.42489226
56MP0001905_abnormal_dopamine_level1.38172231
57MP0002102_abnormal_ear_morphology1.34656928
58MP0000631_abnormal_neuroendocrine_gland1.33519811
59MP0008875_abnormal_xenobiotic_pharmacok1.31122287
60MP0005084_abnormal_gallbladder_morpholo1.29692924
61MP0000026_abnormal_inner_ear1.27380546
62MP0003283_abnormal_digestive_organ1.27343209
63MP0002882_abnormal_neuron_morphology1.26287028
64MP0002234_abnormal_pharynx_morphology1.25789871
65MP0004043_abnormal_pH_regulation1.24008353
66MP0004147_increased_porphyrin_level1.21341459
67MP0008260_abnormal_autophagy1.20686835
68MP0000647_abnormal_sebaceous_gland1.18778241
69MP0001963_abnormal_hearing_physiology1.18103945
70MP0003646_muscle_fatigue1.17628452
71MP0005394_taste/olfaction_phenotype1.16259923
72MP0005499_abnormal_olfactory_system1.16259923
73MP0008569_lethality_at_weaning1.14640161
74MP0005409_darkened_coat_color1.13686803
75MP0005187_abnormal_penis_morphology1.12599610
76MP0002066_abnormal_motor_capabilities/c1.12015103
77MP0000383_abnormal_hair_follicle1.11471656
78MP0003119_abnormal_digestive_system1.10823723
79MP0005167_abnormal_blood-brain_barrier1.10438997
80MP0001919_abnormal_reproductive_system1.09429773
81MP0000955_abnormal_spinal_cord1.06430109
82MP0004145_abnormal_muscle_electrophysio1.06238540
83MP0008995_early_reproductive_senescence1.04331600
84MP0003937_abnormal_limbs/digits/tail_de1.04025559
85MP0005248_abnormal_Harderian_gland1.03746237
86MP0003633_abnormal_nervous_system1.00941878
87MP0004142_abnormal_muscle_tone0.99899087
88MP0005389_reproductive_system_phenotype0.99886990
89MP0001986_abnormal_taste_sensitivity0.99638358
90MP0002160_abnormal_reproductive_system0.98972558
91MP0003011_delayed_dark_adaptation0.98091703
92MP0002752_abnormal_somatic_nervous0.98025121
93MP0003121_genomic_imprinting0.95275506
94MP0002909_abnormal_adrenal_gland0.95168612
95MP0004811_abnormal_neuron_physiology0.94922419
96MP0001177_atelectasis0.94329216
97MP0003183_abnormal_peptide_metabolism0.93271721
98MP0008789_abnormal_olfactory_epithelium0.92196837
99MP0002152_abnormal_brain_morphology0.91211476
100MP0003631_nervous_system_phenotype0.89600257
101MP0005253_abnormal_eye_physiology0.89041098
102MP0003938_abnormal_ear_development0.86638014
103MP0002928_abnormal_bile_duct0.85808886
104MP0005391_vision/eye_phenotype0.85315535
105MP0001485_abnormal_pinna_reflex0.84337281
106MP0008775_abnormal_heart_ventricle0.83801058
107MP0001293_anophthalmia0.83176996
108MP0000538_abnormal_urinary_bladder0.81950644
109MP0002069_abnormal_eating/drinking_beha0.77549447
110MP0002229_neurodegeneration0.76392526
111MP0004215_abnormal_myocardial_fiber0.74850872
112MP0002938_white_spotting0.74355937
113MP0004885_abnormal_endolymph0.74333747
114MP0005535_abnormal_body_temperature0.74257294
115MP0002277_abnormal_respiratory_mucosa0.72138808
116MP0004085_abnormal_heartbeat0.70618531
117MP0003136_yellow_coat_color0.68954972
118MP0005379_endocrine/exocrine_gland_phen0.68628370
119MP0006072_abnormal_retinal_apoptosis0.67512299
120MP0009250_abnormal_appendicular_skeleto0.67459213
121MP0002163_abnormal_gland_morphology0.66572844
122MP0002751_abnormal_autonomic_nervous0.65926367
123MP0000681_abnormal_thyroid_gland0.65714174
124MP0004134_abnormal_chest_morphology0.65382548
125MP0000015_abnormal_ear_pigmentation0.64395254
126MP0000049_abnormal_middle_ear0.64038572
127MP0008872_abnormal_physiological_respon0.63133062
128MP0005195_abnormal_posterior_eye0.63039747
129MP0003632_abnormal_nervous_system0.61365690
130MP0003690_abnormal_glial_cell0.57182196
131MP0008877_abnormal_DNA_methylation0.56797706
132MP0001664_abnormal_digestion0.56794675
133MP0000920_abnormal_myelination0.55688944

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.72703271
2Epileptic encephalopathy (HP:0200134)4.62541311
3Pancreatic cysts (HP:0001737)4.47849337
4Febrile seizures (HP:0002373)4.37817389
5Abnormality of midbrain morphology (HP:0002418)4.35797672
6Molar tooth sign on MRI (HP:0002419)4.35797672
7Pancreatic fibrosis (HP:0100732)4.00513442
8Hyperventilation (HP:0002883)3.76436241
9Nephronophthisis (HP:0000090)3.64051146
10Progressive cerebellar ataxia (HP:0002073)3.50382132
11Focal seizures (HP:0007359)3.42369583
12Abnormal hair whorl (HP:0010721)3.26778116
13Type II lissencephaly (HP:0007260)3.24951375
14Abnormality of the renal medulla (HP:0100957)3.18937245
15Gait imbalance (HP:0002141)3.16648418
16Septo-optic dysplasia (HP:0100842)3.03425042
17Myokymia (HP:0002411)3.03119166
18Medial flaring of the eyebrow (HP:0010747)3.00602339
19Atonic seizures (HP:0010819)2.98238798
20Broad-based gait (HP:0002136)2.95138334
21Nephrogenic diabetes insipidus (HP:0009806)2.92120802
22Protruding tongue (HP:0010808)2.91679151
23Congenital primary aphakia (HP:0007707)2.91295582
24Blue irides (HP:0000635)2.90221913
25Stomach cancer (HP:0012126)2.88826795
26Abnormality of the renal cortex (HP:0011035)2.86213799
27Drooling (HP:0002307)2.82977915
28Excessive salivation (HP:0003781)2.82977915
29Cystic liver disease (HP:0006706)2.78524543
30Pendular nystagmus (HP:0012043)2.77113778
31Impaired vibration sensation in the lower limbs (HP:0002166)2.71817154
32Lissencephaly (HP:0001339)2.60452307
33Narrow nasal bridge (HP:0000446)2.57799802
34Abolished electroretinogram (ERG) (HP:0000550)2.57736279
35Congenital sensorineural hearing impairment (HP:0008527)2.55932345
36Decreased central vision (HP:0007663)2.55083585
37Attenuation of retinal blood vessels (HP:0007843)2.54493446
38Genital tract atresia (HP:0001827)2.51941738
39Large for gestational age (HP:0001520)2.49222716
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.48855100
41Keratoconus (HP:0000563)2.46934423
42Increased corneal curvature (HP:0100692)2.46934423
43Vaginal atresia (HP:0000148)2.45986425
44Tubular atrophy (HP:0000092)2.44157200
45Congenital stationary night blindness (HP:0007642)2.43848697
46Sclerocornea (HP:0000647)2.43815742
47Generalized tonic-clonic seizures (HP:0002069)2.43160207
48Abnormality of salivation (HP:0100755)2.40400035
49Inability to walk (HP:0002540)2.40295343
50Aplasia/Hypoplasia of the lens (HP:0008063)2.40047930
51Gaze-evoked nystagmus (HP:0000640)2.39770683
52Absent septum pellucidum (HP:0001331)2.39234895
53Optic nerve hypoplasia (HP:0000609)2.36568870
54Epileptiform EEG discharges (HP:0011182)2.36461694
55Poor eye contact (HP:0000817)2.35228153
56Aplasia/Hypoplasia of the tibia (HP:0005772)2.29218224
57Concave nail (HP:0001598)2.28212485
58Dysmetria (HP:0001310)2.28027589
59Abnormality of the labia minora (HP:0012880)2.27943151
60Abnormality of the septum pellucidum (HP:0007375)2.27747463
61Absent speech (HP:0001344)2.25995413
62Intestinal atresia (HP:0011100)2.25620330
63Fair hair (HP:0002286)2.24801766
64Exotropia (HP:0000577)2.24642843
65Polyphagia (HP:0002591)2.23992257
66Absent/shortened dynein arms (HP:0200106)2.23076991
67Dynein arm defect of respiratory motile cilia (HP:0012255)2.23076991
68Generalized hypopigmentation of hair (HP:0011358)2.20231823
69Akinesia (HP:0002304)2.20109560
70Anencephaly (HP:0002323)2.19293400
71Poor coordination (HP:0002370)2.18994668
72Acute necrotizing encephalopathy (HP:0006965)2.18931213
73Aplasia involving bones of the upper limbs (HP:0009823)2.18475951
74Aplasia of the phalanges of the hand (HP:0009802)2.18475951
75Aplasia involving bones of the extremities (HP:0009825)2.18475951
76Congenital, generalized hypertrichosis (HP:0004540)2.17909902
77Abnormal rod and cone electroretinograms (HP:0008323)2.16773806
78Mitochondrial inheritance (HP:0001427)2.15552474
79Fetal akinesia sequence (HP:0001989)2.15235844
80Dysdiadochokinesis (HP:0002075)2.14925498
81Cerebellar dysplasia (HP:0007033)2.12807271
82Submucous cleft hard palate (HP:0000176)2.12099366
83Action tremor (HP:0002345)2.11531231
84EEG with generalized epileptiform discharges (HP:0011198)2.11410533
85Abnormal drinking behavior (HP:0030082)2.10335113
86Polydipsia (HP:0001959)2.10335113
87Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09620041
88Congenital hepatic fibrosis (HP:0002612)2.09478483
89Bell-shaped thorax (HP:0001591)2.08650021
90Specific learning disability (HP:0001328)2.08191342
91Limb dystonia (HP:0002451)2.07209789
92Gastrointestinal atresia (HP:0002589)2.02937545
93Increased CSF lactate (HP:0002490)2.01830672
94Esotropia (HP:0000565)2.01636748
95Progressive inability to walk (HP:0002505)2.01144317
96Abnormal eating behavior (HP:0100738)2.01003031
97Aplasia/Hypoplasia of the fovea (HP:0008060)2.00721061
98Hypoplasia of the fovea (HP:0007750)2.00721061
99Sleep apnea (HP:0010535)2.00143088
100Bilateral microphthalmos (HP:0007633)2.00066806
101Furrowed tongue (HP:0000221)1.99394353
102Hypsarrhythmia (HP:0002521)1.99000720
103Male pseudohermaphroditism (HP:0000037)1.98814421
104Colon cancer (HP:0003003)1.97491104
105Genetic anticipation (HP:0003743)1.97435255
106Postaxial foot polydactyly (HP:0001830)1.97431969
107Thickened helices (HP:0000391)1.95769055
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95498595
109Abnormality of alanine metabolism (HP:0010916)1.95498595
110Hyperalaninemia (HP:0003348)1.95498595
111Occipital encephalocele (HP:0002085)1.95168176
112Tented upper lip vermilion (HP:0010804)1.94942777
113Dialeptic seizures (HP:0011146)1.94367720
114Absence seizures (HP:0002121)1.94098637
115Oligodactyly (hands) (HP:0001180)1.94011189
116Progressive macrocephaly (HP:0004481)1.92621999
117Pachygyria (HP:0001302)1.91658679
118Tubulointerstitial nephritis (HP:0001970)1.91039697
119True hermaphroditism (HP:0010459)1.90163059
120Bile duct proliferation (HP:0001408)1.89642699
121Abnormal biliary tract physiology (HP:0012439)1.89642699
122Esophageal atresia (HP:0002032)1.89602688
123Impaired vibratory sensation (HP:0002495)1.89489080
124Slow saccadic eye movements (HP:0000514)1.88742658
125Hypothermia (HP:0002045)1.88184158
126Bony spicule pigmentary retinopathy (HP:0007737)1.87768746
127Acute encephalopathy (HP:0006846)1.87733633
128Abnormal mitochondria in muscle tissue (HP:0008316)1.87395963
129Patellar aplasia (HP:0006443)1.87289124
130Optic disc pallor (HP:0000543)1.86438380
131Short tibia (HP:0005736)1.85739251
132Chronic hepatic failure (HP:0100626)1.84471861
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84429506
134Preaxial hand polydactyly (HP:0001177)1.84213121
135Postaxial hand polydactyly (HP:0001162)1.83936762
136Abnormality of incisor morphology (HP:0011063)1.83430628
137Hemiparesis (HP:0001269)1.83372535
138Chorioretinal atrophy (HP:0000533)1.83276971
139Thyroid-stimulating hormone excess (HP:0002925)1.82962470
140Abnormal ciliary motility (HP:0012262)1.82826105
141Deeply set eye (HP:0000490)1.81772283
142Renal cortical cysts (HP:0000803)1.81099240
143Increased hepatocellular lipid droplets (HP:0006565)1.80503966
144Retinal dysplasia (HP:0007973)1.80091469
145Decreased circulating renin level (HP:0003351)1.79355259
146Recurrent corneal erosions (HP:0000495)1.79132865
147Aplasia/Hypoplasia of the patella (HP:0006498)1.79125540
148Abnormal respiratory epithelium morphology (HP:0012253)1.79061496
149Abnormal respiratory motile cilium morphology (HP:0005938)1.79061496
150Gastroesophageal reflux (HP:0002020)1.78956252
151Amblyopia (HP:0000646)1.78797976
152Severe muscular hypotonia (HP:0006829)1.76934622
153Urinary bladder sphincter dysfunction (HP:0002839)1.76360078
154Split foot (HP:0001839)1.76300297
155Visual hallucinations (HP:0002367)1.76056928
156Scanning speech (HP:0002168)1.75550089
157Abnormality of binocular vision (HP:0011514)1.74030204
158Diplopia (HP:0000651)1.74030204
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72376287
160Absent eyebrow (HP:0002223)1.71959910
161Atelectasis (HP:0100750)1.71402684
162Dyschromatopsia (HP:0007641)1.70696223
163Cutaneous finger syndactyly (HP:0010554)1.70409231
164Abnormal social behavior (HP:0012433)1.68505475
165Impaired social interactions (HP:0000735)1.68505475
166Mixed hearing impairment (HP:0000410)1.68078632
167Spastic gait (HP:0002064)1.67729085
168Morphological abnormality of the middle ear (HP:0008609)1.67087051
169Astigmatism (HP:0000483)1.63607984
170Bradycardia (HP:0001662)1.63356252

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.14690821
2TNIK4.40376269
3FRK4.08422797
4NTRK33.68645307
5WNK33.16776872
6MAP2K72.85407083
7MAP4K22.84163044
8TLK12.72071864
9TIE12.71782245
10PRPF4B2.67472658
11MARK12.48959459
12EPHA42.35798068
13MAP3K42.24262876
14AKT32.17243700
15ACVR1B2.16236154
16MKNK21.98815682
17NUAK11.96794620
18PNCK1.93547318
19SIK31.89915985
20MAPK131.81550043
21WNK41.70807617
22OXSR11.66959276
23PLK21.66727956
24TRIM281.65062894
25DAPK21.58349382
26NTRK21.51583758
27MAP3K121.50143443
28BMPR1B1.46387203
29INSRR1.41872553
30ADRBK21.41784234
31SGK21.40505903
32EPHA31.38189635
33CDK191.36911208
34TAOK31.35942341
35BCR1.33546074
36PAK31.27675668
37NEK61.25811211
38BMPR21.23368061
39SGK2231.19924499
40SGK4941.19924499
41ZAK1.19192087
42MINK11.16838960
43TGFBR11.15013841
44BRD41.14873626
45IRAK11.13512144
46YES11.13116678
47PRKCE1.12452767
48BLK1.09555795
49MAP2K41.09267964
50DAPK11.06589707
51MAPKAPK31.04293492
52CAMK2B1.03416105
53PRKCG1.03043810
54ERBB31.02643166
55CSNK1G11.02623299
56CDK51.00972043
57IRAK21.00480343
58GRK70.99688369
59VRK10.98635544
60CAMK2A0.98342810
61MAP2K60.96921060
62MAPK150.96897869
63CDK80.96745311
64GRK10.91858665
65DYRK1A0.90697825
66GRK50.89688829
67TSSK60.89162960
68BCKDK0.88593477
69RIPK40.86701826
70CDK30.82641365
71STK38L0.81333324
72PIK3CA0.81251798
73PINK10.81100484
74BRSK20.80042199
75CAMK2D0.78603309
76MKNK10.77247961
77TXK0.75619281
78ADRBK10.75356658
79WEE10.73600153
80SGK10.73050392
81NME10.72886276
82CSNK1G20.71378573
83EPHB10.67501323
84LIMK10.67379473
85SGK30.66941175
86CLK10.66579904
87PTK2B0.66276985
88TAOK20.63904475
89PHKG20.63868880
90PHKG10.63868880
91CSNK1A1L0.62875433
92IRAK40.60319867
93TNK20.60303781
94UHMK10.58539145
95NLK0.58329036
96CAMKK20.58281812
97NEK20.58052961
98PKN10.57685707
99VRK20.57450934
100PLK30.56045779
101FES0.55952117
102DYRK20.55169154
103MAPKAPK50.53989460
104KSR10.53466802
105PRKCH0.52156793
106CDK180.52035141
107FER0.51946133
108DYRK30.51219953
109MAPK70.50851691
110FGFR20.48500780
111TEC0.47503146
112IRAK30.47391530
113PRKG10.47245855
114STK390.46522655
115CAMK10.46033469
116FLT30.44886334
117CSNK1G30.43022197
118MUSK0.41780296
119CDK150.41696366
120CDK140.41418750
121EPHB20.41278520
122CAMK2G0.41130783
123RPS6KA50.40776882
124ERBB20.40028123
125MST40.39638241
126CHUK0.39609686
127SIK20.39562141
128MAP3K10.39341172
129PRKACA0.39026582
130STK160.38667838
131CSNK1A10.38425721
132FGR0.35960723
133PRKAA10.35755929
134CAMK40.35413175
135OBSCN0.35358595
136RPS6KB10.35246858
137EIF2AK20.35078887
138CSNK1D0.34211328
139MAP3K60.34140302
140PRKAA20.33952371
141NTRK10.33194567
142CDC42BPA0.32889740
143PRKCB0.31704711
144PRKCI0.31380017
145PRKCZ0.31341119
146CAMK1G0.31214639

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.59550075
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04651164
3Morphine addiction_Homo sapiens_hsa050322.88466429
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86769828
5Circadian entrainment_Homo sapiens_hsa047132.69244919
6Olfactory transduction_Homo sapiens_hsa047402.65216636
7Protein export_Homo sapiens_hsa030602.64739158
8Glutamatergic synapse_Homo sapiens_hsa047242.59296721
9Amphetamine addiction_Homo sapiens_hsa050312.48588119
10GABAergic synapse_Homo sapiens_hsa047272.47819363
11Taste transduction_Homo sapiens_hsa047422.35402302
12Butanoate metabolism_Homo sapiens_hsa006502.25392016
13Nitrogen metabolism_Homo sapiens_hsa009102.24795604
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.19188697
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17927045
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16884357
17Linoleic acid metabolism_Homo sapiens_hsa005912.12746954
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12578378
19Insulin secretion_Homo sapiens_hsa049112.10809841
20Serotonergic synapse_Homo sapiens_hsa047262.09048811
21Cocaine addiction_Homo sapiens_hsa050302.08415278
22Parkinsons disease_Homo sapiens_hsa050122.02346998
23Long-term potentiation_Homo sapiens_hsa047201.99682585
24Phototransduction_Homo sapiens_hsa047441.96108471
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92262497
26Salivary secretion_Homo sapiens_hsa049701.87078115
27Collecting duct acid secretion_Homo sapiens_hsa049661.80398260
28Calcium signaling pathway_Homo sapiens_hsa040201.78844962
29Selenocompound metabolism_Homo sapiens_hsa004501.77381380
30Dopaminergic synapse_Homo sapiens_hsa047281.74543133
31Cholinergic synapse_Homo sapiens_hsa047251.71363026
32RNA polymerase_Homo sapiens_hsa030201.68648462
33Basal transcription factors_Homo sapiens_hsa030221.67509891
34Long-term depression_Homo sapiens_hsa047301.61102144
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55504674
36Axon guidance_Homo sapiens_hsa043601.54968097
37Fanconi anemia pathway_Homo sapiens_hsa034601.45505940
38Huntingtons disease_Homo sapiens_hsa050161.44157898
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44081797
40Tryptophan metabolism_Homo sapiens_hsa003801.42497783
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38437634
42Renin secretion_Homo sapiens_hsa049241.35872704
43Caffeine metabolism_Homo sapiens_hsa002321.34376975
44Oxytocin signaling pathway_Homo sapiens_hsa049211.34178219
45Gastric acid secretion_Homo sapiens_hsa049711.30541954
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.29885415
47Circadian rhythm_Homo sapiens_hsa047101.23080324
48cAMP signaling pathway_Homo sapiens_hsa040241.22199840
49Homologous recombination_Homo sapiens_hsa034401.18865125
50ABC transporters_Homo sapiens_hsa020101.13711010
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13393717
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13116580
53Type II diabetes mellitus_Homo sapiens_hsa049301.13080397
54Vibrio cholerae infection_Homo sapiens_hsa051101.10544374
55RNA degradation_Homo sapiens_hsa030181.10195331
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07597757
57Steroid biosynthesis_Homo sapiens_hsa001001.07040640
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05556620
59Propanoate metabolism_Homo sapiens_hsa006401.05520923
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05304059
61Peroxisome_Homo sapiens_hsa041461.04028818
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01459513
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01094034
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00601068
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00130170
66ErbB signaling pathway_Homo sapiens_hsa040120.98627464
67GnRH signaling pathway_Homo sapiens_hsa049120.97549940
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.96269251
69Rheumatoid arthritis_Homo sapiens_hsa053230.95878847
70Gap junction_Homo sapiens_hsa045400.94424404
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92932629
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91770450
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89909996
74African trypanosomiasis_Homo sapiens_hsa051430.88260808
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87903236
76Chemical carcinogenesis_Homo sapiens_hsa052040.87165877
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84337344
78Dilated cardiomyopathy_Homo sapiens_hsa054140.82519697
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81646819
80Melanogenesis_Homo sapiens_hsa049160.80712629
81Retinol metabolism_Homo sapiens_hsa008300.79144370
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78280963
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78007098
84Type I diabetes mellitus_Homo sapiens_hsa049400.76453966
85Autoimmune thyroid disease_Homo sapiens_hsa053200.76270379
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.75923468
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75437285
88MAPK signaling pathway_Homo sapiens_hsa040100.73408311
89One carbon pool by folate_Homo sapiens_hsa006700.72384102
90Ras signaling pathway_Homo sapiens_hsa040140.71397706
91Wnt signaling pathway_Homo sapiens_hsa043100.70854228
92Histidine metabolism_Homo sapiens_hsa003400.70126847
93Cardiac muscle contraction_Homo sapiens_hsa042600.69399075
94Fat digestion and absorption_Homo sapiens_hsa049750.68420816
95Choline metabolism in cancer_Homo sapiens_hsa052310.65767739
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64624179
97Purine metabolism_Homo sapiens_hsa002300.63879568
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62305685
99Pancreatic secretion_Homo sapiens_hsa049720.61649017
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61178698
101Estrogen signaling pathway_Homo sapiens_hsa049150.61159164
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60883087
103Arachidonic acid metabolism_Homo sapiens_hsa005900.60529235
104Sulfur metabolism_Homo sapiens_hsa009200.59793206
105Metabolic pathways_Homo sapiens_hsa011000.59465133
106Phagosome_Homo sapiens_hsa041450.59314368
107beta-Alanine metabolism_Homo sapiens_hsa004100.58869886
108Dorso-ventral axis formation_Homo sapiens_hsa043200.56530056
109Proteasome_Homo sapiens_hsa030500.55544897
110Mineral absorption_Homo sapiens_hsa049780.54550832
111Ovarian steroidogenesis_Homo sapiens_hsa049130.54069358
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.53683111
113Alcoholism_Homo sapiens_hsa050340.52817412
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51166641
115Glycerolipid metabolism_Homo sapiens_hsa005610.48981157
116Hippo signaling pathway_Homo sapiens_hsa043900.48456299
117Glioma_Homo sapiens_hsa052140.48303090
118Regulation of autophagy_Homo sapiens_hsa041400.47671567
119Ether lipid metabolism_Homo sapiens_hsa005650.45612816
120Inositol phosphate metabolism_Homo sapiens_hsa005620.45243346
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45137259
122Thyroid hormone synthesis_Homo sapiens_hsa049180.43068718
123Rap1 signaling pathway_Homo sapiens_hsa040150.42409939
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41505066
125Melanoma_Homo sapiens_hsa052180.39129109
126Oxidative phosphorylation_Homo sapiens_hsa001900.38850168
127Alzheimers disease_Homo sapiens_hsa050100.38785545
128TGF-beta signaling pathway_Homo sapiens_hsa043500.37655737
129FoxO signaling pathway_Homo sapiens_hsa040680.34451059
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34130612
131Graft-versus-host disease_Homo sapiens_hsa053320.34099989
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33596744
133Sulfur relay system_Homo sapiens_hsa041220.32992946
134Chemokine signaling pathway_Homo sapiens_hsa040620.32377874
135Sphingolipid metabolism_Homo sapiens_hsa006000.31210749
136Folate biosynthesis_Homo sapiens_hsa007900.30469182
137Endometrial cancer_Homo sapiens_hsa052130.30429808
138Fatty acid biosynthesis_Homo sapiens_hsa000610.29547243
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29440287
140Intestinal immune network for IgA production_Homo sapiens_hsa046720.28961289
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28007891
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27276450
143Basal cell carcinoma_Homo sapiens_hsa052170.26762800
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26357421
145Glucagon signaling pathway_Homo sapiens_hsa049220.22219410
146Prolactin signaling pathway_Homo sapiens_hsa049170.19132454
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.18096848
148Hedgehog signaling pathway_Homo sapiens_hsa043400.16978620
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16917109
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14200458
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13948859
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13717014

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