PCDHB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of chemical stimulus (GO:0007606)8.20535488
2chemosensory behavior (GO:0007635)7.88087280
3behavioral response to nicotine (GO:0035095)6.23186353
4drinking behavior (GO:0042756)5.44721680
5centriole replication (GO:0007099)5.40846162
6protein localization to cilium (GO:0061512)5.37495362
7regulation of centriole replication (GO:0046599)5.23202948
8snRNA transcription (GO:0009301)5.22200629
9mating behavior (GO:0007617)5.20590050
10activation of protein kinase A activity (GO:0034199)5.12764850
11male genitalia development (GO:0030539)5.07168846
12negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.94174874
13sequestering of actin monomers (GO:0042989)4.80560190
14receptor guanylyl cyclase signaling pathway (GO:0007168)4.72989231
15cornea development in camera-type eye (GO:0061303)4.67697919
16sulfation (GO:0051923)4.58459667
17regulation of double-strand break repair via homologous recombination (GO:0010569)4.57571815
18water-soluble vitamin biosynthetic process (GO:0042364)4.40721252
19synaptonemal complex assembly (GO:0007130)4.39185440
20regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.26970103
21DNA deamination (GO:0045006)4.20485808
22negative regulation of appetite (GO:0032099)4.11351998
23negative regulation of response to food (GO:0032096)4.11351998
24synaptonemal complex organization (GO:0070193)4.04518937
25kynurenine metabolic process (GO:0070189)4.02891057
26reproductive system development (GO:0061458)4.02682177
27indole-containing compound catabolic process (GO:0042436)4.00618843
28indolalkylamine catabolic process (GO:0046218)4.00618843
29tryptophan catabolic process (GO:0006569)4.00618843
30ovulation cycle (GO:0042698)3.95986389
31indolalkylamine metabolic process (GO:0006586)3.88842086
32tachykinin receptor signaling pathway (GO:0007217)3.88594528
33glial cell proliferation (GO:0014009)3.84968953
34social behavior (GO:0035176)3.81029916
35intraspecies interaction between organisms (GO:0051703)3.81029916
36cellular response to ATP (GO:0071318)3.79119911
37detection of calcium ion (GO:0005513)3.79031871
38negative regulation of transcription regulatory region DNA binding (GO:2000678)3.78701307
39positive regulation of vascular permeability (GO:0043117)3.75987512
40negative regulation of digestive system process (GO:0060457)3.67365965
41left/right axis specification (GO:0070986)3.66585949
42L-fucose catabolic process (GO:0042355)3.64624617
43fucose catabolic process (GO:0019317)3.64624617
44L-fucose metabolic process (GO:0042354)3.64624617
45cell proliferation in forebrain (GO:0021846)3.60766031
46adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.60125784
47protein polyglutamylation (GO:0018095)3.54694947
48ribonucleoprotein complex disassembly (GO:0032988)3.52867636
49centriole assembly (GO:0098534)3.51682209
50negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.50815226
51gamma-aminobutyric acid transport (GO:0015812)3.49960854
52negative regulation of mast cell activation (GO:0033004)3.49490709
53mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.45139487
54positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.45139487
55uronic acid metabolic process (GO:0006063)3.44364532
56glucuronate metabolic process (GO:0019585)3.44364532
57homeostasis of number of cells within a tissue (GO:0048873)3.44090271
58regulation of histone deacetylation (GO:0031063)3.40042556
59tryptophan metabolic process (GO:0006568)3.37709608
60phenylpropanoid metabolic process (GO:0009698)3.36146671
61cGMP biosynthetic process (GO:0006182)3.36072945
62detection of light stimulus involved in sensory perception (GO:0050962)3.33271197
63detection of light stimulus involved in visual perception (GO:0050908)3.33271197
64cellular glucuronidation (GO:0052695)3.33183538
65limb bud formation (GO:0060174)3.30949624
66regulation of cilium movement (GO:0003352)3.26397610
67response to pheromone (GO:0019236)3.24600329
68indole-containing compound metabolic process (GO:0042430)3.20029988
69organelle disassembly (GO:1903008)3.19407576
70neuronal action potential (GO:0019228)3.19375224
71male meiosis (GO:0007140)3.16079824
72eyelid development in camera-type eye (GO:0061029)3.15762285
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15118214
74negative regulation of systemic arterial blood pressure (GO:0003085)3.14968963
75one-carbon compound transport (GO:0019755)3.13828129
76protein complex biogenesis (GO:0070271)3.13066982
77piRNA metabolic process (GO:0034587)3.12835701
78regulation of sodium ion transmembrane transport (GO:1902305)3.10856578
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.10367105
80NADH dehydrogenase complex assembly (GO:0010257)3.10367105
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10367105
82axoneme assembly (GO:0035082)3.05929187
83purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.05502528
843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.05502528
85regulation of action potential (GO:0098900)3.04211750
86antibacterial humoral response (GO:0019731)3.04053862
87negative regulation of cell size (GO:0045792)3.03003469
88serotonin metabolic process (GO:0042428)3.02461104
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01458676
90positive regulation of digestive system process (GO:0060456)2.99670828
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97860674
92negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94221457
93kidney morphogenesis (GO:0060993)2.93543222
94transmission of nerve impulse (GO:0019226)2.92629992
95reflex (GO:0060004)2.91580124
96primary amino compound metabolic process (GO:1901160)2.91408612
97regulation of sodium ion transmembrane transporter activity (GO:2000649)2.90294946
98dosage compensation (GO:0007549)2.89992884
99somite development (GO:0061053)2.89839256
100relaxation of cardiac muscle (GO:0055119)2.88317640
101negative regulation of telomere maintenance (GO:0032205)2.87353749
102membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.87216532
103microtubule polymerization or depolymerization (GO:0031109)2.86401597
104epithelial cilium movement (GO:0003351)2.82922795
105lens morphogenesis in camera-type eye (GO:0002089)2.81631003
106mitochondrial respiratory chain complex assembly (GO:0033108)2.81626495
107regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.81067489
108adaptation of signaling pathway (GO:0023058)2.80809010
109preassembly of GPI anchor in ER membrane (GO:0016254)2.78860921
110olfactory bulb development (GO:0021772)2.78378699
111amine catabolic process (GO:0009310)2.78116959
112cellular biogenic amine catabolic process (GO:0042402)2.78116959
113regulation of hippo signaling (GO:0035330)2.75761444
114regulation of feeding behavior (GO:0060259)2.75334053
115regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75072216
116dorsal/ventral axis specification (GO:0009950)2.74336041
117negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74123012
118negative regulation of DNA-templated transcription, elongation (GO:0032785)2.74123012
119positive regulation of cAMP-mediated signaling (GO:0043950)2.73403683
120axonal fasciculation (GO:0007413)2.72119064
121membrane depolarization during action potential (GO:0086010)2.72039778
122endocrine hormone secretion (GO:0060986)2.71930281
123cellular potassium ion homeostasis (GO:0030007)2.71282199
124rhodopsin mediated signaling pathway (GO:0016056)2.71262106
125antimicrobial humoral response (GO:0019730)2.71097487
126regulation of glomerulus development (GO:0090192)2.69668973
127otic vesicle formation (GO:0030916)2.69283907
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.69222953
129genitalia development (GO:0048806)2.67399321
130photoreceptor cell development (GO:0042461)2.66105557
131regulation of gene silencing by RNA (GO:0060966)2.65946900
132regulation of posttranscriptional gene silencing (GO:0060147)2.65946900
133regulation of gene silencing by miRNA (GO:0060964)2.65946900
134regulation of mesoderm development (GO:2000380)2.64890965
135DNA methylation involved in gamete generation (GO:0043046)2.64089276
136pharyngeal system development (GO:0060037)2.63017260
137protein K11-linked deubiquitination (GO:0035871)2.62911193
138cytidine deamination (GO:0009972)2.61554078
139cytidine metabolic process (GO:0046087)2.61554078
140cytidine catabolic process (GO:0006216)2.61554078
141camera-type eye morphogenesis (GO:0048593)2.61258735
142regulation of cholesterol biosynthetic process (GO:0045540)2.60338508
143flavonoid metabolic process (GO:0009812)2.60152137
144multi-organism behavior (GO:0051705)2.59894144
145neuron cell-cell adhesion (GO:0007158)2.59361002
146positive regulation of fatty acid transport (GO:2000193)2.59234203
147platelet dense granule organization (GO:0060155)2.59154108
148protein insertion into membrane (GO:0051205)2.58684943
149layer formation in cerebral cortex (GO:0021819)2.58014679
150multicellular organism reproduction (GO:0032504)2.56463502
151GPI anchor metabolic process (GO:0006505)2.56119199
152cGMP metabolic process (GO:0046068)2.54099381
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53872837
154positive regulation of defense response to virus by host (GO:0002230)2.53033139
155central nervous system projection neuron axonogenesis (GO:0021952)2.52733106
156calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.52283902
157axon extension (GO:0048675)2.52214813
158parturition (GO:0007567)2.52117449
159spinal cord motor neuron differentiation (GO:0021522)2.51653631
160positive regulation of mitochondrial membrane permeability (GO:0035794)2.51484278
161negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.50946699
162synaptic transmission, cholinergic (GO:0007271)2.49831723
163limb development (GO:0060173)2.49748963
164appendage development (GO:0048736)2.49748963
165regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49624832
166membrane repolarization during action potential (GO:0086011)2.49584977
167negative regulation of glial cell proliferation (GO:0060253)2.49449571
168regulation of response to food (GO:0032095)2.49394378
169negative regulation of astrocyte differentiation (GO:0048712)2.49309369
170cellular ketone body metabolic process (GO:0046950)2.49259663
171regulation of secondary heart field cardioblast proliferation (GO:0003266)2.49032244
172regulation of cardioblast proliferation (GO:0003264)2.49032244
173dendrite morphogenesis (GO:0048813)2.48950690
174regulation of chromatin binding (GO:0035561)2.48232483
175alkaloid metabolic process (GO:0009820)2.47673608
176male meiosis I (GO:0007141)2.46781704
177regulation of neurotransmitter uptake (GO:0051580)2.46343616
178benzene-containing compound metabolic process (GO:0042537)2.44813623
179positive regulation of fatty acid oxidation (GO:0046321)2.43185782
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42912900
181embryonic epithelial tube formation (GO:0001838)2.42847167
182respiratory chain complex IV assembly (GO:0008535)2.42619757
183eye photoreceptor cell development (GO:0042462)2.42109541
184regulation of collateral sprouting (GO:0048670)2.41922602
185nephron epithelium morphogenesis (GO:0072088)2.40420071
186nephron tubule morphogenesis (GO:0072078)2.40420071
187RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40317711
188tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40317711
189endoderm formation (GO:0001706)2.39941579
190dentate gyrus development (GO:0021542)2.34741510
191cilium movement (GO:0003341)2.33477245
192aromatic amino acid family catabolic process (GO:0009074)2.32865304
193sensory perception of smell (GO:0007608)14.9322916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.94770935
2ZNF274_21170338_ChIP-Seq_K562_Hela3.40895369
3DROSHA_22980978_ChIP-Seq_HELA_Human3.11922916
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46127371
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37047160
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37047160
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27827044
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24968055
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18799486
10EWS_26573619_Chip-Seq_HEK293_Human2.09410311
11TAF15_26573619_Chip-Seq_HEK293_Human2.07645272
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.05886843
13FUS_26573619_Chip-Seq_HEK293_Human2.04100130
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01016326
15GATA1_26923725_Chip-Seq_HPCs_Mouse1.99680786
16* EED_16625203_ChIP-ChIP_MESCs_Mouse1.99608379
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.99126245
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98015028
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96636652
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91251204
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88689627
22ER_23166858_ChIP-Seq_MCF-7_Human1.87386400
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87120768
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87093989
25VDR_22108803_ChIP-Seq_LS180_Human1.80705958
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80379248
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.78927537
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.78816801
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78331266
30* REST_21632747_ChIP-Seq_MESCs_Mouse1.77737114
31* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76538857
32AHR_22903824_ChIP-Seq_MCF-7_Human1.74053430
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72609601
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72015895
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70507265
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69965411
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69346390
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68021822
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67576165
40IRF1_19129219_ChIP-ChIP_H3396_Human1.67515298
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63109559
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.61610406
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60655016
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58926439
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.58833021
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.56254390
47BCAT_22108803_ChIP-Seq_LS180_Human1.55943174
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54607265
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.51191894
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50445582
51CBP_20019798_ChIP-Seq_JUKART_Human1.50445582
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.47601228
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.45754235
54TP53_22573176_ChIP-Seq_HFKS_Human1.45553160
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45127004
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45038824
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40867169
58MYC_18940864_ChIP-ChIP_HL60_Human1.40564657
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.38405819
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37457034
61TCF4_23295773_ChIP-Seq_U87_Human1.35420957
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.35324682
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35190834
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34706389
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.33011647
66* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32550384
67IGF1R_20145208_ChIP-Seq_DFB_Human1.31978036
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31570911
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.31234294
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31234294
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.30737569
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29686159
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28046333
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27511749
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27334574
76NCOR_22424771_ChIP-Seq_293T_Human1.27113858
77GF1_26923725_Chip-Seq_HPCs_Mouse1.26244806
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26236803
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25186268
80SOX2_19829295_ChIP-Seq_ESCs_Human1.24981610
81NANOG_19829295_ChIP-Seq_ESCs_Human1.24981610
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24316529
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24113114
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23756109
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.23092028
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23007303
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.22036866
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21644422
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21644422
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21485378
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20861088
92STAT3_23295773_ChIP-Seq_U87_Human1.19759864
93TCF4_22108803_ChIP-Seq_LS180_Human1.19286244
94ZNF263_19887448_ChIP-Seq_K562_Human1.19275032
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.18921671
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18781816
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.18544267
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18022535
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.17720315
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17189350
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15847041
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.15490635
103GBX2_23144817_ChIP-Seq_PC3_Human1.15411671
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.15065545
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14008630
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.13086969
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12984496
108SMAD4_21799915_ChIP-Seq_A2780_Human1.12287139
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11893907
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.11112748
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.10744832
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10334233
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08498673
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08475409
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06750537
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06250097
117KDM2B_26808549_Chip-Seq_K562_Human1.06028258
118HOXB7_26014856_ChIP-Seq_BT474_Human1.05192546
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05107173
120ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04704792
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.04618808
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.04314443
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.03742563
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.03561548
125AR_20517297_ChIP-Seq_VCAP_Human1.03545555
126ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02288821
127* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01711522
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01606064
129WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01218781
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.00597228
131RUNX2_22187159_ChIP-Seq_PCA_Human0.98938810
132EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98659163
133POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98557403
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98531386
135P53_22387025_ChIP-Seq_ESCs_Mouse0.98246186
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97804107
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97619003
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.97317650
139TRIM28_21343339_ChIP-Seq_HEK293_Human0.97228306
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.97105810
141P300_19829295_ChIP-Seq_ESCs_Human0.97090134
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96888270
143AR_25329375_ChIP-Seq_VCAP_Human0.96545582
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95656316
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94604076
146TP53_18474530_ChIP-ChIP_U2OS_Human0.94355040
147* ISL1_27105846_Chip-Seq_CPCs_Mouse0.92813736
148UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92734556
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92317651
150MYC_19915707_ChIP-ChIP_AK7_Human0.91685178
151TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88702744
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87978010
153SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87570959
154RNF2_27304074_Chip-Seq_NSC_Mouse0.87414274
155NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87346622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005394_taste/olfaction_phenotype6.55152792
2MP0005499_abnormal_olfactory_system6.55152792
3MP0008789_abnormal_olfactory_epithelium6.08528952
4MP0003787_abnormal_imprinting4.26327450
5MP0003646_muscle_fatigue2.94987003
6MP0008875_abnormal_xenobiotic_pharmacok2.81783608
7MP0002837_dystrophic_cardiac_calcinosis2.80538730
8MP0005187_abnormal_penis_morphology2.62840130
9MP0002102_abnormal_ear_morphology2.42086611
10MP0001968_abnormal_touch/_nociception2.37038848
11MP0002233_abnormal_nose_morphology2.19619914
12MP0008872_abnormal_physiological_respon2.13205590
13MP0002160_abnormal_reproductive_system2.08884279
14MP0001984_abnormal_olfaction10.2443409
15MP0004145_abnormal_muscle_electrophysio1.91450606
16MP0002653_abnormal_ependyma_morphology1.91315835
17MP0002736_abnormal_nociception_after1.89625940
18MP0003121_genomic_imprinting1.88443910
19MP0002138_abnormal_hepatobiliary_system1.86967611
20MP0001986_abnormal_taste_sensitivity1.83030250
21MP0005389_reproductive_system_phenotype1.82702931
22MP0008877_abnormal_DNA_methylation1.79771821
23MP0004142_abnormal_muscle_tone1.77354022
24MP0003011_delayed_dark_adaptation1.74377942
25MP0001188_hyperpigmentation1.72087773
26MP0009046_muscle_twitch1.71011392
27MP0000569_abnormal_digit_pigmentation1.65171074
28MP0002638_abnormal_pupillary_reflex1.61226924
29MP0004270_analgesia1.60337210
30MP0002234_abnormal_pharynx_morphology1.55547418
31MP0005253_abnormal_eye_physiology1.53283240
32MP0002163_abnormal_gland_morphology1.49921097
33MP0000631_abnormal_neuroendocrine_gland1.48357025
34MP0005365_abnormal_bile_salt1.46876772
35MP0002735_abnormal_chemical_nociception1.42187618
36MP0000372_irregular_coat_pigmentation1.42036734
37MP0002184_abnormal_innervation1.41587143
38MP0002909_abnormal_adrenal_gland1.39788408
39MP0010030_abnormal_orbit_morphology1.38608082
40MP0000427_abnormal_hair_cycle1.30757646
41MP0003880_abnormal_central_pattern1.30616669
42MP0001486_abnormal_startle_reflex1.29514153
43MP0002734_abnormal_mechanical_nocicepti1.29359053
44MP0001501_abnormal_sleep_pattern1.29265650
45MP0001485_abnormal_pinna_reflex1.27889696
46MP0005174_abnormal_tail_pigmentation1.27434297
47MP0002733_abnormal_thermal_nociception1.26868328
48MP0003136_yellow_coat_color1.26472523
49MP0004859_abnormal_synaptic_plasticity1.26337034
50MP0004130_abnormal_muscle_cell1.24407533
51MP0009780_abnormal_chondrocyte_physiolo1.23968676
52MP0002928_abnormal_bile_duct1.23629426
53MP0005084_abnormal_gallbladder_morpholo1.23445001
54MP0001970_abnormal_pain_threshold1.23407536
55MP0001919_abnormal_reproductive_system1.22876280
56MP0002938_white_spotting1.21661688
57MP0002876_abnormal_thyroid_physiology1.19484728
58MP0003635_abnormal_synaptic_transmissio1.18022269
59MP0003942_abnormal_urinary_system1.18019768
60MP0006276_abnormal_autonomic_nervous1.15667586
61MP0004147_increased_porphyrin_level1.15193334
62MP0005379_endocrine/exocrine_gland_phen1.15161972
63MP0005645_abnormal_hypothalamus_physiol1.13259869
64MP0005551_abnormal_eye_electrophysiolog1.11547382
65MP0002063_abnormal_learning/memory/cond1.09875995
66MP0010386_abnormal_urinary_bladder1.08235145
67MP0004134_abnormal_chest_morphology1.06800540
68MP0002752_abnormal_somatic_nervous1.05226079
69MP0003123_paternal_imprinting1.03840448
70MP0005195_abnormal_posterior_eye1.03007144
71MP0005671_abnormal_response_to1.02532883
72MP0001905_abnormal_dopamine_level1.01810947
73MP0010234_abnormal_vibrissa_follicle1.01516257
74MP0008058_abnormal_DNA_repair1.00765462
75MP0002882_abnormal_neuron_morphology1.00701611
76MP0000049_abnormal_middle_ear0.97292958
77MP0005646_abnormal_pituitary_gland0.96290140
78MP0002751_abnormal_autonomic_nervous0.91853724
79MP0000647_abnormal_sebaceous_gland0.91436879
80MP0003283_abnormal_digestive_organ0.89900081
81MP0000778_abnormal_nervous_system0.89627263
82MP0000383_abnormal_hair_follicle0.89508653
83MP0002067_abnormal_sensory_capabilities0.88419354
84MP0000230_abnormal_systemic_arterial0.88280064
85MP0002557_abnormal_social/conspecific_i0.87782368
86MP0001293_anophthalmia0.87302417
87MP0005075_abnormal_melanosome_morpholog0.87240013
88MP0001440_abnormal_grooming_behavior0.87166378
89MP0005410_abnormal_fertilization0.86889023
90MP0008995_early_reproductive_senescence0.86407845
91MP0008775_abnormal_heart_ventricle0.86048818
92MP0003252_abnormal_bile_duct0.85802372
93MP0003195_calcinosis0.84970674
94MP0002272_abnormal_nervous_system0.84703499
95MP0002572_abnormal_emotion/affect_behav0.83896188
96MP0002064_seizures0.82683263
97MP0001963_abnormal_hearing_physiology0.82259890
98MP0003755_abnormal_palate_morphology0.82226778
99MP0004215_abnormal_myocardial_fiber0.81373599
100MP0002249_abnormal_larynx_morphology0.79081629
101MP0010329_abnormal_lipoprotein_level0.78149297
102MP0004885_abnormal_endolymph0.78034477
103MP0001958_emphysema0.77534084
104MP0001502_abnormal_circadian_rhythm0.77391713
105MP0003122_maternal_imprinting0.76621241
106MP0003119_abnormal_digestive_system0.75538122
107MP0003879_abnormal_hair_cell0.75335421
108MP0005332_abnormal_amino_acid0.75172528
109MP0003638_abnormal_response/metabolism_0.74324054
110MP0002152_abnormal_brain_morphology0.74011075
111MP0003937_abnormal_limbs/digits/tail_de0.73476513
112MP0009703_decreased_birth_body0.72344636
113MP0002095_abnormal_skin_pigmentation0.71954665
114MP0006292_abnormal_olfactory_placode0.70205934
115MP0004133_heterotaxia0.70127495
116MP0009745_abnormal_behavioral_response0.65953167
117MP0004043_abnormal_pH_regulation0.64709933
118MP0004742_abnormal_vestibular_system0.63949377
119MP0005171_absent_coat_pigmentation0.63868733
120MP0004924_abnormal_behavior0.62538378
121MP0005386_behavior/neurological_phenoty0.62538378
122MP0004085_abnormal_heartbeat0.61920465
123MP0003183_abnormal_peptide_metabolism0.61232514
124MP0009672_abnormal_birth_weight0.60708427
125MP0000534_abnormal_ureter_morphology0.60047011
126MP0003329_amyloid_beta_deposits0.59546007
127MP0001324_abnormal_eye_pigmentation0.59431226
128MP0005377_hearing/vestibular/ear_phenot0.58336848
129MP0003878_abnormal_ear_physiology0.58336848
130MP0004811_abnormal_neuron_physiology0.58147136
131MP0002896_abnormal_bone_mineralization0.57380083
132MP0005257_abnormal_intraocular_pressure0.57304275
133MP0002277_abnormal_respiratory_mucosa0.56925618
134MP0001346_abnormal_lacrimal_gland0.56348486
135MP0003861_abnormal_nervous_system0.56079390
136MP0003315_abnormal_perineum_morphology0.53642059
137MP0000026_abnormal_inner_ear0.53362363
138MP0005220_abnormal_exocrine_pancreas0.53189122
139MP0002822_catalepsy0.52301997
140MP0005423_abnormal_somatic_nervous0.51510302
141MP0001299_abnormal_eye_distance/0.51444485
142MP0001727_abnormal_embryo_implantation0.51048853
143MP0002177_abnormal_outer_ear0.50479388
144MP0003935_abnormal_craniofacial_develop0.50399344
145MP0001944_abnormal_pancreas_morphology0.49192297
146MP0005623_abnormal_meninges_morphology0.48777333
147MP0003938_abnormal_ear_development0.47933069
148MP0001177_atelectasis0.47708336
149MP0000537_abnormal_urethra_morphology0.46412889
150MP0006072_abnormal_retinal_apoptosis0.45762150
151MP0003300_gastrointestinal_ulcer0.45647484
152MP0002116_abnormal_craniofacial_bone0.45465139
153MP0003137_abnormal_impulse_conducting0.44745159
154MP0002877_abnormal_melanocyte_morpholog0.43685722

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)5.65661561
2Cone-rod dystrophy (HP:0000548)4.97917610
3Febrile seizures (HP:0002373)4.80918580
4Pancreatic cysts (HP:0001737)4.58541631
5Abnormality of macular pigmentation (HP:0008002)4.47989737
6Atonic seizures (HP:0010819)4.31333442
7Pancreatic fibrosis (HP:0100732)4.21283261
8Pelvic girdle muscle weakness (HP:0003749)4.19783379
9True hermaphroditism (HP:0010459)4.16283655
10Bell-shaped thorax (HP:0001591)4.03516951
11Congenital stationary night blindness (HP:0007642)4.00583531
12Hypochromic microcytic anemia (HP:0004840)3.75690273
13Abnormality of the hip-girdle musculature (HP:0001445)3.74691750
14Abnormality of the musculature of the pelvis (HP:0001469)3.74691750
15Palpitations (HP:0001962)3.73424723
16Decreased central vision (HP:0007663)3.64667167
17Molar tooth sign on MRI (HP:0002419)3.64503022
18Abnormality of midbrain morphology (HP:0002418)3.64503022
19Pendular nystagmus (HP:0012043)3.62843610
20Generalized tonic-clonic seizures (HP:0002069)3.59996301
21Anosmia (HP:0000458)3.49662152
22Focal seizures (HP:0007359)3.43196199
23Abolished electroretinogram (ERG) (HP:0000550)3.41948185
24Abnormal respiratory epithelium morphology (HP:0012253)3.31640796
25Abnormal respiratory motile cilium morphology (HP:0005938)3.31640796
26Hyperventilation (HP:0002883)3.28664655
27Decreased electroretinogram (ERG) amplitude (HP:0000654)3.27665084
28Genetic anticipation (HP:0003743)3.24145838
29Glucose intolerance (HP:0000833)3.16975057
30Abnormality of the renal cortex (HP:0011035)3.07998649
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)3.05883725
32Attenuation of retinal blood vessels (HP:0007843)3.03947764
33Limb dystonia (HP:0002451)3.03314531
34Absent rod-and cone-mediated responses on ERG (HP:0007688)3.02760600
35Intellectual disability, moderate (HP:0002342)2.98841736
36Subacute progressive viral hepatitis (HP:0006572)2.96930362
37Inappropriate behavior (HP:0000719)2.95190680
38Progressive cerebellar ataxia (HP:0002073)2.94727545
39Abnormal rod and cone electroretinograms (HP:0008323)2.89610326
40Abnormality of the renal medulla (HP:0100957)2.87099288
41Exotropia (HP:0000577)2.85961229
42Cystic liver disease (HP:0006706)2.83558748
43Xerostomia (HP:0000217)2.83378943
44Absence seizures (HP:0002121)2.80875597
45Abnormality of the intervertebral disk (HP:0005108)2.78234466
46Type II lissencephaly (HP:0007260)2.75062619
47Hyperthyroidism (HP:0000836)2.70445813
48Decreased circulating renin level (HP:0003351)2.67864762
49Dialeptic seizures (HP:0011146)2.66696713
50Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.64848016
51Palpebral edema (HP:0100540)2.63287342
52Methylmalonic acidemia (HP:0002912)2.59721579
53Gait imbalance (HP:0002141)2.57136904
54Furrowed tongue (HP:0000221)2.56747652
55Aplasia/Hypoplasia of the earlobes (HP:0009906)2.56719694
56Gaze-evoked nystagmus (HP:0000640)2.56152176
57Insulin-resistant diabetes mellitus (HP:0000831)2.53625605
58Enlarged penis (HP:0000040)2.51362287
59Sclerocornea (HP:0000647)2.49308723
60Abnormal ciliary motility (HP:0012262)2.48719964
61Abnormal respiratory motile cilium physiology (HP:0012261)2.44793144
62Abnormality of salivation (HP:0100755)2.43228359
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42739463
64Abnormality of alanine metabolism (HP:0010916)2.42739463
65Hyperalaninemia (HP:0003348)2.42739463
66Ketoacidosis (HP:0001993)2.41625231
67Renal cortical cysts (HP:0000803)2.39972067
68Congenital primary aphakia (HP:0007707)2.38989432
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.38857889
70Abnormality of dentin (HP:0010299)2.34914977
71Asplenia (HP:0001746)2.33625218
72Abnormal glucose tolerance (HP:0001952)2.33510556
73Medial flaring of the eyebrow (HP:0010747)2.33101517
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.33001097
75Abnormality of the epiphyses of the hand (HP:0005924)2.32653318
76Congenital sensorineural hearing impairment (HP:0008527)2.32474409
77Elfin facies (HP:0004428)2.31762163
78Chorioretinal atrophy (HP:0000533)2.29243482
79Tubular atrophy (HP:0000092)2.29054412
80Methylmalonic aciduria (HP:0012120)2.27463893
81Agitation (HP:0000713)2.27067441
82Syncope (HP:0001279)2.26897396
83Bifid scrotum (HP:0000048)2.26006725
84Advanced eruption of teeth (HP:0006288)2.23793159
85Keratoconus (HP:0000563)2.23216228
86Increased corneal curvature (HP:0100692)2.23216228
87Excessive salivation (HP:0003781)2.23153068
88Drooling (HP:0002307)2.23153068
89Nephrogenic diabetes insipidus (HP:0009806)2.21615308
903-Methylglutaconic aciduria (HP:0003535)2.19974537
91Slow-growing hair (HP:0002217)2.17433188
92Abnormality of hair growth rate (HP:0011363)2.17433188
93Broad-based gait (HP:0002136)2.17279729
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.15905577
95Anencephaly (HP:0002323)2.15605373
96Focal motor seizures (HP:0011153)2.13314423
97Bradycardia (HP:0001662)2.12085620
98Intention tremor (HP:0002080)2.09980041
99Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.09526011
100Micronodular cirrhosis (HP:0001413)2.08958430
101Abnormality of the renal collecting system (HP:0004742)2.06530391
102Hypoplasia of the uterus (HP:0000013)2.05087983
103Bony spicule pigmentary retinopathy (HP:0007737)2.03855059
104Congenital hepatic fibrosis (HP:0002612)2.03682162
105Neonatal onset (HP:0003623)2.03428203
106Prolonged QT interval (HP:0001657)2.03183677
107Inability to walk (HP:0002540)2.02649643
108Protruding tongue (HP:0010808)2.01985094
109Acute necrotizing encephalopathy (HP:0006965)2.01935334
110Ulnar bowing (HP:0003031)2.01816978
111Mitochondrial inheritance (HP:0001427)2.01767542
112Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00972953
113Lip pit (HP:0100267)2.00847092
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00515587
115Optic nerve hypoplasia (HP:0000609)2.00352011
116Absent/shortened dynein arms (HP:0200106)2.00322850
117Dynein arm defect of respiratory motile cilia (HP:0012255)2.00322850
118Megalencephaly (HP:0001355)1.99935091
119Stereotypic behavior (HP:0000733)1.98318313
120Hyperlipoproteinemia (HP:0010980)1.98300303
121Hyperaldosteronism (HP:0000859)1.97441238
122Concave nail (HP:0001598)1.96908251
123Male pseudohermaphroditism (HP:0000037)1.95958800
124IgG deficiency (HP:0004315)1.95191417
125Genital tract atresia (HP:0001827)1.94772354
126Natal tooth (HP:0000695)1.94001747
127Facial cleft (HP:0002006)1.93901522
128Aplasia/hypoplasia of the uterus (HP:0008684)1.93646917
129Tubulointerstitial fibrosis (HP:0005576)1.93489079
130Hemiparesis (HP:0001269)1.92329813
131Tubulointerstitial abnormality (HP:0001969)1.91387947
132Abnormal drinking behavior (HP:0030082)1.91166796
133Polydipsia (HP:0001959)1.91166796
134Large for gestational age (HP:0001520)1.90251337
135Increased CSF lactate (HP:0002490)1.90033678
136Postaxial foot polydactyly (HP:0001830)1.89579289
137Congenital, generalized hypertrichosis (HP:0004540)1.88343108
138Absent thumb (HP:0009777)1.88075876
139Postaxial hand polydactyly (HP:0001162)1.88019673
140Short tibia (HP:0005736)1.87559127
141Severe visual impairment (HP:0001141)1.87242800
142Progressive macrocephaly (HP:0004481)1.86686438
143Nephronophthisis (HP:0000090)1.85463566
144Abnormal hemoglobin (HP:0011902)1.85209727
145Thyroiditis (HP:0100646)1.84860949
146Renovascular hypertension (HP:0100817)1.84527611
147Abnormality of the frontal sinuses (HP:0002687)1.82666956
148Vaginal atresia (HP:0000148)1.82315676
149Bronchomalacia (HP:0002780)1.81919072
150Atelectasis (HP:0100750)1.81850340
151Small hand (HP:0200055)1.81817374
152Polyuria (HP:0000103)1.81700042
153Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80139091
154Stomach cancer (HP:0012126)1.79882519
155Optic disc pallor (HP:0000543)1.79855264
156Progressive inability to walk (HP:0002505)1.78302620
157Tapered finger (HP:0001182)1.77789192
158Chronic hepatic failure (HP:0100626)1.76699403
159Median cleft lip (HP:0000161)1.76426537
160Abnormality of sodium homeostasis (HP:0010931)1.75968620
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75940280
162Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75235895
163Atrioventricular block (HP:0001678)1.75087861
164Abnormality of the nasal septum (HP:0000419)1.74003712
165Clumsiness (HP:0002312)1.73779118
166Abnormal number of erythroid precursors (HP:0012131)1.72765734
167Abnormality of the proximal phalanges of the hand (HP:0009834)1.72676157
168Aplasia/Hypoplasia of the patella (HP:0006498)1.71070367
169Short hallux (HP:0010109)1.70616576
170Aplasia/Hypoplasia of the hallux (HP:0008362)1.70613943
171Abnormality of the pons (HP:0007361)1.70157263
172Confusion (HP:0001289)1.69818791
173Severe muscular hypotonia (HP:0006829)1.69650001
174Acute encephalopathy (HP:0006846)1.68794015
175Cerebellar dysplasia (HP:0007033)1.68160412
176Hypoplasia of the pons (HP:0012110)1.67355304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB37.34937882
2PLK47.23764327
3INSRR4.60827696
4BLK4.40049453
5BMPR24.21084360
6ADRBK23.80004854
7PLK23.67534771
8GRK13.41314898
9CDK193.24610303
10BMPR1B2.95019479
11MAP4K22.72996352
12ZAK2.52077054
13PINK12.50001041
14TAOK32.44257077
15TLK12.24011061
16NUAK12.19671516
17ACVR1B2.13774827
18WNK32.13704333
19TXK2.12873930
20TNIK2.06502023
21SIK22.01176224
22WNK41.94456572
23OXSR11.93617940
24DAPK21.65898276
25NTRK31.63972850
26BCKDK1.61696185
27PAK31.55635859
28CASK1.50228338
29MARK11.48369397
30MAPK151.29346176
31TYRO31.29151680
32CAMKK21.25954616
33SIK11.16097182
34TIE11.10675686
35MAP3K21.09560710
36KSR21.05684387
37CAMK2D1.05389775
38IKBKB1.03374284
39AKT31.02922249
40TEC0.98662187
41VRK10.98535927
42BRD40.96270930
43PRKCE0.95914271
44CAMK2B0.94112238
45NTRK20.91463270
46HIPK20.88110483
47MUSK0.87649679
48CSNK1G10.87194022
49PTK2B0.83343286
50KIT0.82416573
51STK38L0.81188371
52VRK20.80735832
53STK110.79363324
54TRIM280.78673136
55STK390.75689817
56GRK70.73247613
57MAPKAPK30.72222552
58PHKG10.71915256
59PHKG20.71915256
60MKNK20.71557507
61PRKD20.69383325
62TGFBR10.68404707
63BRSK20.67684846
64FER0.67233588
65MINK10.64041995
66PDPK10.62690269
67MAP2K60.61453747
68PRKCQ0.61093209
69ITK0.60372374
70MAP3K100.59519323
71RPS6KA50.59355342
72NTRK10.59092639
73FRK0.58703375
74SYK0.56080423
75PAK60.55250650
76CDK50.55126754
77CSNK1A10.55050365
78PRKACA0.54508358
79CAMK2G0.53826449
80STK160.53322068
81MAP3K40.52606437
82DYRK1B0.52389020
83PRKCI0.52318463
84CSNK1A1L0.51504248
85FLT30.51449479
86OBSCN0.51268604
87UHMK10.50128615
88TNK20.49998613
89CDK60.49216445
90CAMK1G0.48490618
91MAPKAPK50.47799590
92PDK10.47679079
93EPHA30.47336149
94CHUK0.47024098
95MARK20.46659612
96LMTK20.45692190
97PRKCG0.45261597
98TAF10.44853872
99CSNK1G20.43591017
100ERBB20.43515318
101NME10.42641827
102MST40.42539084
103MAP3K90.42359527
104PRKCA0.41356714
105PNCK0.41342000
106MAP2K20.40722116
107CAMK2A0.40545919
108SGK4940.40192887
109SGK2230.40192887
110STK30.39772684
111PIK3CA0.39555571
112IRAK10.38400351
113EPHA40.38048085
114DDR20.37853098
115CSNK1D0.37835235
116GRK50.37569828
117FGFR20.37116159
118YES10.35800892
119NLK0.35126319
120GRK60.35026145
121CSNK1G30.31765532
122ABL10.31279823
123PRKCH0.30784034
124RIPK40.30678305
125MAP2K10.29100864
126KSR10.27042161
127FYN0.26393886
128CDC42BPA0.25872093
129JAK10.25102761
130PRKG10.25045786
131MAP2K70.24717285
132CAMKK10.24241999
133ROCK20.23561292
134DYRK20.23428429
135TRIB30.23345993
136CAMK10.23150821
137MAP2K40.23101247
138INSR0.23066249
139SGK30.22886451
140MAPK130.22840203
141TTK0.22731824
142PKN10.21823180
143RIPK10.21386037
144MAP3K70.20838885
145IGF1R0.20686072
146STK240.20574182
147BCR0.20306756
148FGFR30.20119008
149ADRBK10.18842559
150MAPK90.18344759
151NEK20.17989645
152JAK20.17540754
153MAPK100.17263318
154CSNK1E0.17120173
155GSK3A0.16313088
156PIK3CG0.16067891
157PTK60.15922343
158FES0.15920997
159PRKCZ0.15640324
160CAMK40.15609927
161PRKCB0.14595966

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.72709740
2Phototransduction_Homo sapiens_hsa047443.02632945
3Caffeine metabolism_Homo sapiens_hsa002322.68204084
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42809209
5Nitrogen metabolism_Homo sapiens_hsa009102.42113449
6Linoleic acid metabolism_Homo sapiens_hsa005912.40858175
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26209809
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.25726478
9Oxidative phosphorylation_Homo sapiens_hsa001902.24246072
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.21000753
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16396573
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11428003
13Sulfur metabolism_Homo sapiens_hsa009202.09407676
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.06233942
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97973312
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96613896
17Dorso-ventral axis formation_Homo sapiens_hsa043201.95628226
18Collecting duct acid secretion_Homo sapiens_hsa049661.94672172
19Homologous recombination_Homo sapiens_hsa034401.91161955
20Thyroid hormone synthesis_Homo sapiens_hsa049181.87612142
21Selenocompound metabolism_Homo sapiens_hsa004501.83000079
22Vibrio cholerae infection_Homo sapiens_hsa051101.80460870
23Synaptic vesicle cycle_Homo sapiens_hsa047211.67536586
24Parkinsons disease_Homo sapiens_hsa050121.61971962
25RNA polymerase_Homo sapiens_hsa030201.60717593
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.58915665
27Insulin secretion_Homo sapiens_hsa049111.58830215
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57537665
29Ether lipid metabolism_Homo sapiens_hsa005651.47834085
30Butanoate metabolism_Homo sapiens_hsa006501.47010484
31Morphine addiction_Homo sapiens_hsa050321.43166131
32Glutathione metabolism_Homo sapiens_hsa004801.37132164
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32156230
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.31716538
35Taste transduction_Homo sapiens_hsa047421.31195164
36Ovarian steroidogenesis_Homo sapiens_hsa049131.31032657
37Primary immunodeficiency_Homo sapiens_hsa053401.30834794
38Fanconi anemia pathway_Homo sapiens_hsa034601.29840894
39Basal transcription factors_Homo sapiens_hsa030221.28765396
40Protein export_Homo sapiens_hsa030601.27333727
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26670404
42Salivary secretion_Homo sapiens_hsa049701.22329784
43Circadian entrainment_Homo sapiens_hsa047131.21655972
44GnRH signaling pathway_Homo sapiens_hsa049121.19641929
45Gastric acid secretion_Homo sapiens_hsa049711.18965221
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18610612
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17973806
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17820883
49Cardiac muscle contraction_Homo sapiens_hsa042601.17290991
50ABC transporters_Homo sapiens_hsa020101.16227513
51Estrogen signaling pathway_Homo sapiens_hsa049151.16045841
52Cholinergic synapse_Homo sapiens_hsa047251.14861125
53Adherens junction_Homo sapiens_hsa045201.13789986
54GABAergic synapse_Homo sapiens_hsa047271.13462549
55Dopaminergic synapse_Homo sapiens_hsa047281.11560666
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10391446
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09738597
58Alzheimers disease_Homo sapiens_hsa050101.09607494
59Endometrial cancer_Homo sapiens_hsa052131.08076077
60Huntingtons disease_Homo sapiens_hsa050161.06355714
61Histidine metabolism_Homo sapiens_hsa003401.06335958
62Type II diabetes mellitus_Homo sapiens_hsa049301.02993510
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02704422
64Arachidonic acid metabolism_Homo sapiens_hsa005901.02413785
65Asthma_Homo sapiens_hsa053101.02174217
66RNA degradation_Homo sapiens_hsa030181.01577083
67Peroxisome_Homo sapiens_hsa041461.00228346
68Glycerolipid metabolism_Homo sapiens_hsa005610.99148342
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98000707
70One carbon pool by folate_Homo sapiens_hsa006700.97790342
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.97758219
72Bile secretion_Homo sapiens_hsa049760.97452652
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95923588
74Glutamatergic synapse_Homo sapiens_hsa047240.94610939
75Ribosome_Homo sapiens_hsa030100.90439303
76Glioma_Homo sapiens_hsa052140.90437056
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89761618
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89758043
79Renal cell carcinoma_Homo sapiens_hsa052110.89503659
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87428662
81Fat digestion and absorption_Homo sapiens_hsa049750.86971812
82Notch signaling pathway_Homo sapiens_hsa043300.85669860
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84036596
84cAMP signaling pathway_Homo sapiens_hsa040240.80238450
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79695522
86FoxO signaling pathway_Homo sapiens_hsa040680.79318849
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78358937
88Serotonergic synapse_Homo sapiens_hsa047260.77745095
89Chemical carcinogenesis_Homo sapiens_hsa052040.77081350
90Melanogenesis_Homo sapiens_hsa049160.76322925
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74438240
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.73694421
93Gap junction_Homo sapiens_hsa045400.73300408
94Nicotine addiction_Homo sapiens_hsa050330.72020266
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70325131
96beta-Alanine metabolism_Homo sapiens_hsa004100.70187597
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70157388
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67829720
99Vitamin digestion and absorption_Homo sapiens_hsa049770.67566554
100Prolactin signaling pathway_Homo sapiens_hsa049170.67197882
101Amphetamine addiction_Homo sapiens_hsa050310.66655334
102Axon guidance_Homo sapiens_hsa043600.66532862
103ErbB signaling pathway_Homo sapiens_hsa040120.64023403
104Sulfur relay system_Homo sapiens_hsa041220.63249072
105Regulation of autophagy_Homo sapiens_hsa041400.62558859
106Oxytocin signaling pathway_Homo sapiens_hsa049210.61629901
107Pyruvate metabolism_Homo sapiens_hsa006200.60710549
108Starch and sucrose metabolism_Homo sapiens_hsa005000.60327371
109Type I diabetes mellitus_Homo sapiens_hsa049400.59826299
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.58837821
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57899933
112Purine metabolism_Homo sapiens_hsa002300.57298382
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57273490
114Long-term potentiation_Homo sapiens_hsa047200.55638003
115Fatty acid biosynthesis_Homo sapiens_hsa000610.54739297
116Retinol metabolism_Homo sapiens_hsa008300.53968509
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53550097
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53459578
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52876577
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52709875
121Graft-versus-host disease_Homo sapiens_hsa053320.52707658
122Chronic myeloid leukemia_Homo sapiens_hsa052200.52218538
123Metabolic pathways_Homo sapiens_hsa011000.52055014
124Wnt signaling pathway_Homo sapiens_hsa043100.51577816
125Pancreatic secretion_Homo sapiens_hsa049720.50338672
126Hepatitis C_Homo sapiens_hsa051600.50218954
127Allograft rejection_Homo sapiens_hsa053300.49800244
128Chemokine signaling pathway_Homo sapiens_hsa040620.49174339
129Propanoate metabolism_Homo sapiens_hsa006400.48910065
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48879646
131Autoimmune thyroid disease_Homo sapiens_hsa053200.46769052
132Renin secretion_Homo sapiens_hsa049240.45277348
133Pyrimidine metabolism_Homo sapiens_hsa002400.44278060
134Rheumatoid arthritis_Homo sapiens_hsa053230.44271799
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43648475
136Colorectal cancer_Homo sapiens_hsa052100.43628170
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43335187
138Hedgehog signaling pathway_Homo sapiens_hsa043400.42584263
139Non-small cell lung cancer_Homo sapiens_hsa052230.41673458
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41071956
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.40571883
142Prostate cancer_Homo sapiens_hsa052150.39722893
143Basal cell carcinoma_Homo sapiens_hsa052170.39308058
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39227978
145Calcium signaling pathway_Homo sapiens_hsa040200.38302280
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38068793
147Mineral absorption_Homo sapiens_hsa049780.36876729
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36577068
149MAPK signaling pathway_Homo sapiens_hsa040100.34735430
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34236866
151Hematopoietic cell lineage_Homo sapiens_hsa046400.33902394
152Nucleotide excision repair_Homo sapiens_hsa034200.32683478
153Cocaine addiction_Homo sapiens_hsa050300.31859781
154Alcoholism_Homo sapiens_hsa050340.31396181
155Insulin signaling pathway_Homo sapiens_hsa049100.30744087
156Tryptophan metabolism_Homo sapiens_hsa003800.28691169

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