PCDHA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of glycogen biosynthetic process (GO:0045719)8.21341975
2UDP-N-acetylglucosamine metabolic process (GO:0006047)7.35599797
3negative regulation of glycogen metabolic process (GO:0070874)6.79224582
4neuron cell-cell adhesion (GO:0007158)5.83053331
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.56759954
6vocalization behavior (GO:0071625)5.50877209
7phosphorelay signal transduction system (GO:0000160)5.38443767
8positive regulation of cardiac muscle cell differentiation (GO:2000727)5.25578404
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19247607
10kidney morphogenesis (GO:0060993)5.10902848
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09221035
12synaptic vesicle exocytosis (GO:0016079)4.98628937
13protein localization to synapse (GO:0035418)4.86550654
14ovulation cycle (GO:0042698)4.86471872
15glutamate secretion (GO:0014047)4.85939510
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.84164341
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75901230
18regulation of glutamate receptor signaling pathway (GO:1900449)4.71203153
19regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.60907293
20layer formation in cerebral cortex (GO:0021819)4.54892994
21synaptic vesicle maturation (GO:0016188)4.52020170
22lung secretory cell differentiation (GO:0061140)4.49769629
23neuron recognition (GO:0008038)4.47272718
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.41326346
25glutamate receptor signaling pathway (GO:0007215)4.35446654
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34714625
27regulation of synaptic vesicle exocytosis (GO:2000300)4.32644522
28locomotory exploration behavior (GO:0035641)4.29883750
29pyrimidine nucleobase catabolic process (GO:0006208)4.29879491
30postsynaptic membrane organization (GO:0001941)4.29053556
31presynaptic membrane assembly (GO:0097105)4.27574645
32regulation of glomerulus development (GO:0090192)4.22467269
33somite development (GO:0061053)4.20662971
34head development (GO:0060322)4.16168413
35synaptic transmission, glutamatergic (GO:0035249)4.15229567
36exploration behavior (GO:0035640)4.14493326
37axonal fasciculation (GO:0007413)4.13560668
38neuron-neuron synaptic transmission (GO:0007270)4.10783393
39regulation of non-canonical Wnt signaling pathway (GO:2000050)4.08267601
40neuronal action potential propagation (GO:0019227)4.06214080
41axon ensheathment in central nervous system (GO:0032291)4.06056959
42central nervous system myelination (GO:0022010)4.06056959
43positive regulation of synapse maturation (GO:0090129)4.05607766
44membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.02023734
45estrogen metabolic process (GO:0008210)3.99562508
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99108823
47neurotransmitter-gated ion channel clustering (GO:0072578)3.94084469
48dendritic spine morphogenesis (GO:0060997)3.93529397
49presynaptic membrane organization (GO:0097090)3.93416776
50sulfation (GO:0051923)3.89673500
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.89518522
52neurotransmitter secretion (GO:0007269)3.89417029
53cellular response to ATP (GO:0071318)3.89069940
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.84689546
55regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79925344
56cell migration in hindbrain (GO:0021535)3.79873077
57spinal cord development (GO:0021510)3.79214638
58transmission of nerve impulse (GO:0019226)3.78588967
59central nervous system projection neuron axonogenesis (GO:0021952)3.77530921
60regulation of synaptic vesicle transport (GO:1902803)3.75584943
61glucosamine-containing compound metabolic process (GO:1901071)3.72317767
62regulation of neuronal synaptic plasticity (GO:0048168)3.72111853
63gamma-aminobutyric acid transport (GO:0015812)3.71697177
64regulation of synapse structural plasticity (GO:0051823)3.71668366
65dendrite morphogenesis (GO:0048813)3.69926741
66protein polyglutamylation (GO:0018095)3.65680790
67behavioral response to nicotine (GO:0035095)3.61813594
68DNA deamination (GO:0045006)3.61543507
69serotonin metabolic process (GO:0042428)3.60912854
70positive regulation of oligodendrocyte differentiation (GO:0048714)3.60622394
71regulation of excitatory postsynaptic membrane potential (GO:0060079)3.55072505
72regulation of neurotransmitter uptake (GO:0051580)3.53792806
73membrane repolarization during action potential (GO:0086011)3.53571882
74cell proliferation in forebrain (GO:0021846)3.53437983
75synapse assembly (GO:0007416)3.52522652
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.51898782
773-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.51898782
78nucleobase catabolic process (GO:0046113)3.51618586
79water-soluble vitamin biosynthetic process (GO:0042364)3.51113915
80response to pheromone (GO:0019236)3.49320215
81regulation of postsynaptic membrane potential (GO:0060078)3.46224747
82regulation of dendritic spine morphogenesis (GO:0061001)3.46106292
83regulation of mesoderm development (GO:2000380)3.45114180
84positive regulation of membrane potential (GO:0045838)3.44975311
85positive regulation of glomerulus development (GO:0090193)3.44788000
86negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43198333
87behavioral defense response (GO:0002209)3.43126861
88behavioral fear response (GO:0001662)3.43126861
89response to histamine (GO:0034776)3.42304442
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.40309305
91cerebellar granule cell differentiation (GO:0021707)3.39235405
92adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.37560094
93positive regulation of neurotransmitter secretion (GO:0001956)3.36928387
94proline transport (GO:0015824)3.36304934
95segment specification (GO:0007379)3.35465044
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34610743
97cellular potassium ion homeostasis (GO:0030007)3.34034244
98positive regulation of potassium ion transmembrane transport (GO:1901381)3.33419101
99smooth muscle tissue development (GO:0048745)3.33215685
100regulation of synapse maturation (GO:0090128)3.33174747
101innervation (GO:0060384)3.32691995
102neuron remodeling (GO:0016322)3.32472883
103lateral sprouting from an epithelium (GO:0060601)3.32340026
104magnesium ion transport (GO:0015693)3.31070889
105long-term memory (GO:0007616)3.30874605
106positive regulation of triglyceride biosynthetic process (GO:0010867)3.29774186
107fear response (GO:0042596)3.27733626
108regulation of neurotransmitter secretion (GO:0046928)3.26529446
109positive regulation of meiosis (GO:0045836)3.23487963
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23094323
111primary amino compound metabolic process (GO:1901160)3.22631458
112positive regulation of dendritic spine development (GO:0060999)3.19287451
113regulation of synaptic transmission, glutamatergic (GO:0051966)3.17966582
114regulation of dendritic spine development (GO:0060998)3.17568639
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17137456
116regulation of vesicle fusion (GO:0031338)3.15271633
117positive regulation of synapse assembly (GO:0051965)3.15071882
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14725149
119neurotransmitter transport (GO:0006836)3.13574541
120cochlea development (GO:0090102)3.12913865
121regulation of synaptic plasticity (GO:0048167)3.10637081
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10407327
123cellular response to interferon-beta (GO:0035458)3.09347081
124negative regulation of protein tyrosine kinase activity (GO:0061099)3.08349248
125negative regulation of astrocyte differentiation (GO:0048712)3.08121523
126peristalsis (GO:0030432)3.07508264
127establishment of mitochondrion localization (GO:0051654)3.07252663
128regulation of interleukin-12 biosynthetic process (GO:0045075)3.07014088
129nucleotide-sugar biosynthetic process (GO:0009226)3.06195126
130dendrite development (GO:0016358)3.05295116
131central nervous system neuron axonogenesis (GO:0021955)3.04219216
132negative regulation of cardiac muscle tissue growth (GO:0055022)3.03467764
133negative regulation of heart growth (GO:0061117)3.03467764
134regulation of regulatory T cell differentiation (GO:0045589)3.03331691
135startle response (GO:0001964)3.03091399
136negative regulation of hormone biosynthetic process (GO:0032353)3.02710836
137auditory behavior (GO:0031223)3.02503727
138endoderm formation (GO:0001706)3.02361194
139interferon-gamma secretion (GO:0072643)3.02120233
140positive regulation of neurotransmitter transport (GO:0051590)3.02087892
141synapse organization (GO:0050808)3.01866135
142membrane depolarization (GO:0051899)3.01608902
143learning (GO:0007612)3.00704832
144positive regulation of meiotic cell cycle (GO:0051446)2.99313706
145membrane hyperpolarization (GO:0060081)2.97357033
146membrane depolarization during action potential (GO:0086010)2.96861163
147mitochondrion transport along microtubule (GO:0047497)2.96224769
148establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.96224769
149activation of protein kinase A activity (GO:0034199)2.95933656
150endocrine pancreas development (GO:0031018)2.94660663
151negative regulation of cardiac muscle tissue development (GO:0055026)2.90767467
152axon extension (GO:0048675)2.90367895
153regulation of neurotransmitter transport (GO:0051588)2.90307531
154synaptic vesicle endocytosis (GO:0048488)2.89816005
155mechanosensory behavior (GO:0007638)2.89611822
156mating behavior (GO:0007617)2.89490471
157regulation of synapse assembly (GO:0051963)2.88206479
158long-term synaptic potentiation (GO:0060291)2.87298401
159musculoskeletal movement (GO:0050881)2.86748230
160multicellular organismal movement (GO:0050879)2.86748230
161synaptic transmission (GO:0007268)2.85812872
162glutamine metabolic process (GO:0006541)2.85160529
163retinal ganglion cell axon guidance (GO:0031290)2.84576215
164regulation of female receptivity (GO:0045924)2.83813600
165regulation of neurotransmitter levels (GO:0001505)2.83613720
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83037839
167regulation of cardiac muscle cell proliferation (GO:0060043)2.80345053
168regulation of cardiac muscle cell differentiation (GO:2000725)2.80293401
169phagocytosis, recognition (GO:0006910)2.80249855
170positive regulation of fatty acid transport (GO:2000193)2.76478220
171positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.75132042
172preassembly of GPI anchor in ER membrane (GO:0016254)2.74483381
173regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.74310497
174positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.71584944
175regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.69344120
176multicellular organismal signaling (GO:0035637)2.67962511
177positive regulation of icosanoid secretion (GO:0032305)2.67355553
178regulation of membrane repolarization (GO:0060306)2.66002892
179amino sugar metabolic process (GO:0006040)2.65099831
180positive regulation of metanephros development (GO:0072216)2.64480362
181negative regulation of organelle assembly (GO:1902116)2.62847805
182cornea development in camera-type eye (GO:0061303)2.61424644
183negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59843336
184lung morphogenesis (GO:0060425)2.59436884
185somatic diversification of immunoglobulins (GO:0016445)2.58493005
186pituitary gland development (GO:0021983)2.58374789
187synaptic transmission, cholinergic (GO:0007271)2.58138610
188regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.57709345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.40707115
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.30362396
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.33711231
4GBX2_23144817_ChIP-Seq_PC3_Human4.05002124
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98632973
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97971540
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86640758
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64526114
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.62169824
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50131930
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50131930
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49676525
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47965943
14REST_21632747_ChIP-Seq_MESCs_Mouse2.45407479
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40382813
16TAF15_26573619_Chip-Seq_HEK293_Human2.36919031
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.34387706
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34226423
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23317746
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.21775769
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21609220
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16202130
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15532223
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09315293
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.07004218
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04980445
27DROSHA_22980978_ChIP-Seq_HELA_Human1.99964726
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94074390
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93969846
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.91906335
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90511084
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.84757699
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82004921
34AR_21572438_ChIP-Seq_LNCaP_Human1.77979735
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76579297
36IRF1_19129219_ChIP-ChIP_H3396_Human1.75787940
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.75529430
38SMAD4_21799915_ChIP-Seq_A2780_Human1.73970562
39P300_19829295_ChIP-Seq_ESCs_Human1.73062072
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69817459
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67262465
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60881604
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59617769
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58646765
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58255085
46EWS_26573619_Chip-Seq_HEK293_Human1.57539459
47RNF2_27304074_Chip-Seq_NSC_Mouse1.51473078
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48022787
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.45000996
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44474965
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.44288290
52IGF1R_20145208_ChIP-Seq_DFB_Human1.44116382
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43651721
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42526714
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42105687
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41580706
57FUS_26573619_Chip-Seq_HEK293_Human1.40987228
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.40676903
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40368562
60ZNF274_21170338_ChIP-Seq_K562_Hela1.39631875
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34648155
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32255004
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32239542
64AR_25329375_ChIP-Seq_VCAP_Human1.29743228
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.29712971
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28903050
67STAT3_23295773_ChIP-Seq_U87_Human1.28251596
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27673103
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27616158
70VDR_22108803_ChIP-Seq_LS180_Human1.27292617
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26692120
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.25488057
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25394626
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.24041854
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21860981
76AHR_22903824_ChIP-Seq_MCF-7_Human1.21776115
77* RING1B_27294783_Chip-Seq_ESCs_Mouse1.20036347
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19422059
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19422059
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17747997
81TCF4_23295773_ChIP-Seq_U87_Human1.17154835
82BCAT_22108803_ChIP-Seq_LS180_Human1.16752359
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15971509
84TP53_20018659_ChIP-ChIP_R1E_Mouse1.14840514
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14592142
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.13954710
87TP53_18474530_ChIP-ChIP_U2OS_Human1.13509225
88AR_19668381_ChIP-Seq_PC3_Human1.11715142
89RUNX2_22187159_ChIP-Seq_PCA_Human1.11489555
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10589279
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09775023
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09482225
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09156544
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08711094
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08281440
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.08220009
97ER_23166858_ChIP-Seq_MCF-7_Human1.07459598
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06915605
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06848192
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06588790
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.05672064
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05536023
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05392401
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.05392401
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04499758
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04232261
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03886316
108JUN_21703547_ChIP-Seq_K562_Human1.03144548
109TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02288726
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00091214
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.98939901
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96966756
113ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96412298
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.95106916
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94723259
116KDM2B_26808549_Chip-Seq_REH_Human0.93503034
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.93260071
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92295241
119KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91910169
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91687829
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91058911
122CMYC_18555785_Chip-Seq_ESCs_Mouse0.90722331
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90412286
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.89215794
125SMRT_27268052_Chip-Seq_Bcells_Human0.89016480
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87738337
127NANOG_19829295_ChIP-Seq_ESCs_Human0.87456580
128SOX2_19829295_ChIP-Seq_ESCs_Human0.87456580
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.85577253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.66282088
2MP0003880_abnormal_central_pattern4.62014335
3MP0003635_abnormal_synaptic_transmissio3.96832656
4MP0004270_analgesia3.89535833
5MP0003646_muscle_fatigue3.75426360
6MP0009745_abnormal_behavioral_response3.25091108
7MP0002063_abnormal_learning/memory/cond3.24793439
8MP0009046_muscle_twitch2.98772017
9MP0001968_abnormal_touch/_nociception2.93893898
10MP0002064_seizures2.91372900
11MP0003567_abnormal_fetal_cardiomyocyte2.90255308
12MP0002572_abnormal_emotion/affect_behav2.80640017
13MP0002735_abnormal_chemical_nociception2.65876957
14MP0000778_abnormal_nervous_system2.59509763
15MP0001486_abnormal_startle_reflex2.59426367
16MP0002734_abnormal_mechanical_nocicepti2.58880790
17MP0005379_endocrine/exocrine_gland_phen2.57226081
18MP0005423_abnormal_somatic_nervous2.54039811
19MP0006292_abnormal_olfactory_placode2.51493907
20MP0002272_abnormal_nervous_system2.47304986
21MP0002160_abnormal_reproductive_system2.45931136
22MP0006276_abnormal_autonomic_nervous2.35438112
23MP0001440_abnormal_grooming_behavior2.27331958
24MP0002736_abnormal_nociception_after2.26389312
25MP0002184_abnormal_innervation2.22006647
26MP0002733_abnormal_thermal_nociception2.19671247
27MP0005389_reproductive_system_phenotype2.15390631
28MP0002138_abnormal_hepatobiliary_system2.12331395
29MP0000537_abnormal_urethra_morphology2.11809414
30MP0002067_abnormal_sensory_capabilities2.08444738
31MP0000383_abnormal_hair_follicle2.05227900
32MP0001984_abnormal_olfaction1.99352553
33MP0001970_abnormal_pain_threshold1.96044972
34MP0001501_abnormal_sleep_pattern1.94501872
35MP0003011_delayed_dark_adaptation1.93961505
36MP0003787_abnormal_imprinting1.93479752
37MP0002557_abnormal_social/conspecific_i1.90696311
38MP0009780_abnormal_chondrocyte_physiolo1.83503384
39MP0004924_abnormal_behavior1.74001402
40MP0005386_behavior/neurological_phenoty1.74001402
41MP0004811_abnormal_neuron_physiology1.72252645
42MP0000955_abnormal_spinal_cord1.66970167
43MP0009053_abnormal_anal_canal1.66249130
44MP0002822_catalepsy1.63193150
45MP0001919_abnormal_reproductive_system1.62475371
46MP0001188_hyperpigmentation1.61798239
47MP0003329_amyloid_beta_deposits1.58275105
48MP0002909_abnormal_adrenal_gland1.58134409
49MP0000049_abnormal_middle_ear1.56341343
50MP0002882_abnormal_neuron_morphology1.53886040
51MP0003937_abnormal_limbs/digits/tail_de1.50256832
52MP0003119_abnormal_digestive_system1.45638632
53MP0005645_abnormal_hypothalamus_physiol1.43992716
54MP0008569_lethality_at_weaning1.43730443
55MP0005394_taste/olfaction_phenotype1.43576146
56MP0005499_abnormal_olfactory_system1.43576146
57MP0010386_abnormal_urinary_bladder1.42836118
58MP0002066_abnormal_motor_capabilities/c1.41755167
59MP0003879_abnormal_hair_cell1.40520053
60MP0002139_abnormal_hepatobiliary_system1.39794923
61MP0004858_abnormal_nervous_system1.38849633
62MP0001905_abnormal_dopamine_level1.38416572
63MP0005646_abnormal_pituitary_gland1.36405062
64MP0004742_abnormal_vestibular_system1.35435944
65MP0001293_anophthalmia1.31767067
66MP0009250_abnormal_appendicular_skeleto1.30880494
67MP0002152_abnormal_brain_morphology1.24939722
68MP0001529_abnormal_vocalization1.22934191
69MP0005408_hypopigmentation1.22688689
70MP0004133_heterotaxia1.20289536
71MP0010678_abnormal_skin_adnexa1.19743319
72MP0001502_abnormal_circadian_rhythm1.18396589
73MP0008789_abnormal_olfactory_epithelium1.15955735
74MP0000427_abnormal_hair_cycle1.14527530
75MP0004885_abnormal_endolymph1.14300839
76MP0002102_abnormal_ear_morphology1.13216557
77MP0004019_abnormal_vitamin_homeostasis1.12285244
78MP0004142_abnormal_muscle_tone1.11345576
79MP0005195_abnormal_posterior_eye1.09702096
80MP0000685_abnormal_immune_system1.08074199
81MP0008995_early_reproductive_senescence1.05731007
82MP0003122_maternal_imprinting1.05315143
83MP0005551_abnormal_eye_electrophysiolog1.03608025
84MP0003633_abnormal_nervous_system1.03484511
85MP0008877_abnormal_DNA_methylation1.02727200
86MP0002653_abnormal_ependyma_morphology1.01518797
87MP0002752_abnormal_somatic_nervous1.01191131
88MP0003786_premature_aging1.00844289
89MP0004085_abnormal_heartbeat0.97611076
90MP0003890_abnormal_embryonic-extraembry0.97341997
91MP0000569_abnormal_digit_pigmentation0.97121617
92MP0000631_abnormal_neuroendocrine_gland0.96540453
93MP0001963_abnormal_hearing_physiology0.96537503
94MP0003878_abnormal_ear_physiology0.96099895
95MP0005377_hearing/vestibular/ear_phenot0.96099895
96MP0003631_nervous_system_phenotype0.94908089
97MP0002229_neurodegeneration0.94653429
98MP0000751_myopathy0.93631234
99MP0002876_abnormal_thyroid_physiology0.92976481
100MP0002069_abnormal_eating/drinking_beha0.92014311
101MP0002277_abnormal_respiratory_mucosa0.91556026
102MP0003942_abnormal_urinary_system0.90441794
103MP0006072_abnormal_retinal_apoptosis0.90076840
104MP0003861_abnormal_nervous_system0.87368193
105MP0002928_abnormal_bile_duct0.87084408
106MP0002837_dystrophic_cardiac_calcinosis0.86721724
107MP0003634_abnormal_glial_cell0.86379486
108MP0001177_atelectasis0.86077555
109MP0005084_abnormal_gallbladder_morpholo0.85245658
110MP0008775_abnormal_heart_ventricle0.82947239
111MP0002254_reproductive_system_inflammat0.82246439
112MP0003136_yellow_coat_color0.81674124
113MP0004145_abnormal_muscle_electrophysio0.79973722
114MP0000647_abnormal_sebaceous_gland0.79931685
115MP0003283_abnormal_digestive_organ0.79384900
116MP0005409_darkened_coat_color0.78084455
117MP0002938_white_spotting0.77676565
118MP0000613_abnormal_salivary_gland0.77224063
119MP0002282_abnormal_trachea_morphology0.76924060
120MP0001348_abnormal_lacrimal_gland0.76245269
121MP0002751_abnormal_autonomic_nervous0.76155939
122MP0002089_abnormal_postnatal_growth/wei0.75319842
123MP0000026_abnormal_inner_ear0.75197202
124MP0005410_abnormal_fertilization0.74556664
125MP0008874_decreased_physiological_sensi0.73977281
126MP0005647_abnormal_sex_gland0.73660894
127MP0003137_abnormal_impulse_conducting0.72742169
128MP0008872_abnormal_physiological_respon0.71732989
129MP0002932_abnormal_joint_morphology0.71103187
130MP0003632_abnormal_nervous_system0.67731713
131MP0001664_abnormal_digestion0.67730264
132MP0004215_abnormal_myocardial_fiber0.65433302
133MP0005535_abnormal_body_temperature0.64830948
134MP0001299_abnormal_eye_distance/0.64167575
135MP0002638_abnormal_pupillary_reflex0.63913013
136MP0002082_postnatal_lethality0.61209447
137MP0010770_preweaning_lethality0.61209447
138MP0010769_abnormal_survival0.59419370
139MP0001943_abnormal_respiration0.58917230
140MP0005253_abnormal_eye_physiology0.57882133
141MP0005187_abnormal_penis_morphology0.57008237
142MP0000920_abnormal_myelination0.56489522
143MP0010768_mortality/aging0.56021332
144MP0002090_abnormal_vision0.55921881
145MP0000604_amyloidosis0.55462751
146MP0001485_abnormal_pinna_reflex0.54934913
147MP0003121_genomic_imprinting0.54751941
148MP0003938_abnormal_ear_development0.54053400

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.87438628
2Myokymia (HP:0002411)5.48020510
3Focal seizures (HP:0007359)5.45771521
4Epileptic encephalopathy (HP:0200134)5.25622759
5Abnormality of the proximal phalanges of the hand (HP:0009834)5.05009171
6Atonic seizures (HP:0010819)5.01172709
7Febrile seizures (HP:0002373)4.98027550
8Visual hallucinations (HP:0002367)4.88250703
9Fatigable weakness (HP:0003473)4.62751200
10Abnormality of the neuromuscular junction (HP:0003398)4.62751200
11Abnormality of the middle phalanges of the toes (HP:0010183)4.50500539
12Hyperventilation (HP:0002883)4.40797573
13Progressive cerebellar ataxia (HP:0002073)4.31911819
14Absence seizures (HP:0002121)4.06821640
15Hypoplasia of the uterus (HP:0000013)4.05974052
16Congenital stationary night blindness (HP:0007642)4.00137249
17Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.75557060
18Dialeptic seizures (HP:0011146)3.71621116
19Short hallux (HP:0010109)3.67165749
20Drooling (HP:0002307)3.60857889
21Excessive salivation (HP:0003781)3.60857889
22Broad-based gait (HP:0002136)3.60128174
23Generalized tonic-clonic seizures (HP:0002069)3.53791971
24Symphalangism affecting the phalanges of the hand (HP:0009773)3.52297760
25Abnormality of the phalanges of the 5th finger (HP:0004213)3.51409556
26Pendular nystagmus (HP:0012043)3.48844741
27Aplasia/Hypoplasia of the hallux (HP:0008362)3.48782936
28Amblyopia (HP:0000646)3.47186015
29Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.43223168
30Conjunctival hamartoma (HP:0100780)3.36496638
31Aplasia/hypoplasia of the uterus (HP:0008684)3.32055425
32Abnormality of the phalanges of the 2nd finger (HP:0009541)3.31869350
33Progressive inability to walk (HP:0002505)3.31134364
34Mildly elevated creatine phosphokinase (HP:0008180)3.29015249
35Abnormality of the nasal septum (HP:0000419)3.18574745
36Nephronophthisis (HP:0000090)3.17675415
37Amyotrophic lateral sclerosis (HP:0007354)3.15178350
38Abnormality of the corticospinal tract (HP:0002492)3.09737485
39Mutism (HP:0002300)3.07039326
40Short 1st metacarpal (HP:0010034)3.06803737
41Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.06803737
42Stomach cancer (HP:0012126)3.05302926
43Pancreatic fibrosis (HP:0100732)3.04799439
44Supranuclear gaze palsy (HP:0000605)3.01337893
45Limb dystonia (HP:0002451)3.00495513
46Inability to walk (HP:0002540)2.99070804
47Decreased subcutaneous fat (HP:0001002)2.98928630
48Gaze-evoked nystagmus (HP:0000640)2.97608266
49Osteomalacia (HP:0002749)2.94437142
50Fibular aplasia (HP:0002990)2.94256133
51Pancreatic cysts (HP:0001737)2.90922434
52Molar tooth sign on MRI (HP:0002419)2.90475901
53Abnormality of midbrain morphology (HP:0002418)2.90475901
54Alveolar cell carcinoma (HP:0006519)2.89860156
55Chorioretinal atrophy (HP:0000533)2.86874518
56Poor eye contact (HP:0000817)2.86064932
57Hamartoma of the eye (HP:0010568)2.85767034
58Erythroderma (HP:0001019)2.82650003
59Humeroradial synostosis (HP:0003041)2.81572774
60Synostosis involving the elbow (HP:0003938)2.81572774
61Absent speech (HP:0001344)2.79694549
62Morphological abnormality of the middle ear (HP:0008609)2.75492593
63Urinary bladder sphincter dysfunction (HP:0002839)2.73782887
64True hermaphroditism (HP:0010459)2.73568118
65Insidious onset (HP:0003587)2.73014688
66Termporal pattern (HP:0011008)2.73014688
67Genetic anticipation (HP:0003743)2.72041582
68Action tremor (HP:0002345)2.70239885
69Abnormality of the 1st metacarpal (HP:0010009)2.69878235
70Gait imbalance (HP:0002141)2.69782203
71Proximal amyotrophy (HP:0007126)2.69022161
72Neoplasm of the tracheobronchial system (HP:0100552)2.67785600
73Abnormality of the renal medulla (HP:0100957)2.66904285
74Impaired social interactions (HP:0000735)2.66079525
75Abnormal social behavior (HP:0012433)2.66079525
76Truncal ataxia (HP:0002078)2.65589034
77Epileptiform EEG discharges (HP:0011182)2.65258664
78Synostosis of carpal bones (HP:0005048)2.65122889
79Protruding tongue (HP:0010808)2.65120375
80Easy fatigability (HP:0003388)2.61965422
81Dysdiadochokinesis (HP:0002075)2.60279568
82Hemiparesis (HP:0001269)2.56624947
83Epidermoid cyst (HP:0200040)2.56564064
84Cerebral inclusion bodies (HP:0100314)2.56220885
85Diplopia (HP:0000651)2.55564808
86Abnormality of binocular vision (HP:0011514)2.55564808
87Neurofibrillary tangles (HP:0002185)2.55546579
88Keratoconus (HP:0000563)2.55107668
89Increased corneal curvature (HP:0100692)2.55107668
90Impaired vibration sensation in the lower limbs (HP:0002166)2.53780096
91Dysmetria (HP:0001310)2.51174442
92Impaired smooth pursuit (HP:0007772)2.51173198
93EEG with generalized epileptiform discharges (HP:0011198)2.47998181
94Akinesia (HP:0002304)2.47664650
95Absent/shortened dynein arms (HP:0200106)2.46382593
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.46382593
97Ankle clonus (HP:0011448)2.45886133
98Polyphagia (HP:0002591)2.45778402
99Abnormality of salivation (HP:0100755)2.45468202
100Abnormal eating behavior (HP:0100738)2.43758830
101Hyperlipoproteinemia (HP:0010980)2.40433660
102Adactyly (HP:0009776)2.38942556
103Adrenal hypoplasia (HP:0000835)2.38202376
104Hematochezia (HP:0002573)2.36855578
105Hyperglycinemia (HP:0002154)2.35946614
106Asplenia (HP:0001746)2.35870673
107Aplasia involving bones of the upper limbs (HP:0009823)2.34633602
108Aplasia of the phalanges of the hand (HP:0009802)2.34633602
109Aplasia involving bones of the extremities (HP:0009825)2.34633602
110Fetal akinesia sequence (HP:0001989)2.33863875
111Hypsarrhythmia (HP:0002521)2.33194496
112Aplasia/Hypoplasia of the brainstem (HP:0007362)2.32755929
113Hypoplasia of the brainstem (HP:0002365)2.32755929
114Abolished electroretinogram (ERG) (HP:0000550)2.32551697
115Depression (HP:0000716)2.31440679
116Stereotypic behavior (HP:0000733)2.31292733
117Agitation (HP:0000713)2.30828230
118Generalized myoclonic seizures (HP:0002123)2.28554477
119Aplasia/Hypoplasia of the spleen (HP:0010451)2.28399975
120Furrowed tongue (HP:0000221)2.28329026
121Abnormality of subcutaneous fat tissue (HP:0001001)2.27052540
122Spastic gait (HP:0002064)2.24970977
1232-3 toe syndactyly (HP:0004691)2.24211898
124Abnormal rod and cone electroretinograms (HP:0008323)2.22872698
125Retinal dysplasia (HP:0007973)2.22606985
126Exotropia (HP:0000577)2.20142822
127Aplasia/Hypoplasia of the sternum (HP:0006714)2.20138542
128Abnormality of the lower motor neuron (HP:0002366)2.19400046
129Methylmalonic acidemia (HP:0002912)2.18039426
130Lissencephaly (HP:0001339)2.17293038
131Status epilepticus (HP:0002133)2.17235233
132Abnormal ciliary motility (HP:0012262)2.15899386
133Urinary urgency (HP:0000012)2.15689695
134Anxiety (HP:0000739)2.15407197
135Methylmalonic aciduria (HP:0012120)2.12745924
136Septo-optic dysplasia (HP:0100842)2.11720344
137Abnormality of ocular smooth pursuit (HP:0000617)2.11205125
138Cystic liver disease (HP:0006706)2.10679437
139Neck muscle weakness (HP:0000467)2.08689591
140Scanning speech (HP:0002168)2.08458583
141Short femoral neck (HP:0100864)2.08164857
142Short phalanx of the thumb (HP:0009660)2.03274043
143Pachygyria (HP:0001302)2.01405889
144Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.01375105
145Papilledema (HP:0001085)2.01125504
146Obstructive sleep apnea (HP:0002870)2.00545023
147Specific learning disability (HP:0001328)2.00103058
148Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99889850
149Degeneration of the lateral corticospinal tracts (HP:0002314)1.98050902
150Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98050902
151Abnormal respiratory epithelium morphology (HP:0012253)1.96578016
152Abnormal respiratory motile cilium morphology (HP:0005938)1.96578016
153Inappropriate behavior (HP:0000719)1.95590951
154Absent phalangeal crease (HP:0006109)1.94983453
155Broad hallux (HP:0010055)1.94970083
156Postural instability (HP:0002172)1.93902684
157Hyperthyroidism (HP:0000836)1.93470826
158Abnormality of the renal cortex (HP:0011035)1.92945900
159Medial flaring of the eyebrow (HP:0010747)1.92134939
160Sclerocornea (HP:0000647)1.91051471
161Bone cyst (HP:0012062)1.90732786
162Abnormality of the 2nd finger (HP:0004100)1.90188641
163Lower limb muscle weakness (HP:0007340)1.89779509
164Congenital primary aphakia (HP:0007707)1.89457664
165Pheochromocytoma (HP:0002666)1.89406832
166Aqueductal stenosis (HP:0002410)1.89073174
167Gowers sign (HP:0003391)1.88838556
168Gastroesophageal reflux (HP:0002020)1.88580686
169Blue irides (HP:0000635)1.88226372
170Absent thumb (HP:0009777)1.87947579
171Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.87718181
172Hemiplegia (HP:0002301)1.87178562
173Morphological abnormality of the pyramidal tract (HP:0002062)1.86703140
174Widely spaced teeth (HP:0000687)1.86626048
175Goiter (HP:0000853)1.85918228
176Torticollis (HP:0000473)1.85748546
177Abnormal respiratory motile cilium physiology (HP:0012261)1.85682127
178Intellectual disability, severe (HP:0010864)1.85538410
179Abnormality of alanine metabolism (HP:0010916)1.84867680
180Hyperalaninemia (HP:0003348)1.84867680
181Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84867680
182Abnormality of DNA repair (HP:0003254)1.82581553
183Impaired vibratory sensation (HP:0002495)1.82046828
184Nephrogenic diabetes insipidus (HP:0009806)1.81077077
185Thickened helices (HP:0000391)1.77196385
186Megalencephaly (HP:0001355)1.74190344
187Sleep apnea (HP:0010535)1.73364760
188Bradykinesia (HP:0002067)1.72820298

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.53004553
2NTRK33.89320366
3FRK3.78061125
4CASK3.67302636
5PINK13.57467866
6MAPKAPK33.39459190
7EPHA43.29877342
8MAP2K73.17482072
9MAP3K43.14230674
10GRK13.09104334
11DAPK22.59907491
12INSRR2.48664112
13MINK12.46651735
14MAP3K92.42747788
15NTRK22.23143698
16MAPK132.22269337
17ACVR1B2.20396066
18TNIK2.05122838
19MAP2K42.02691956
20PKN22.02666140
21MAP3K122.00460641
22PAK61.87406937
23FLT31.83640481
24PLK21.59314038
25WNK41.56749602
26PNCK1.55191336
27DAPK11.54237189
28CDK51.49158007
29KSR11.40035569
30SIK21.39139585
31PHKG11.33966173
32PHKG21.33966173
33MAP4K21.31922324
34NTRK11.31089500
35RIPK41.29713265
36PRPF4B1.27701024
37GRK51.27209721
38PRKAA11.24527291
39DYRK21.24069970
40PRKCG1.18948550
41LATS21.13464162
42CAMKK11.06294612
43CSNK1G21.03021889
44FES1.02285388
45SGK2231.00967276
46SGK4941.00967276
47CAMK2A1.00247284
48CDK140.97466957
49AKT30.97336003
50MARK20.97092733
51KSR20.96253138
52ERBB30.95187023
53CDK180.94963749
54UHMK10.94282737
55CAMKK20.94248593
56CAMK2B0.93010730
57CDK150.91354377
58SGK20.89712451
59CDK190.87214968
60STK38L0.86720964
61PAK30.86139290
62LIMK10.85921968
63DYRK30.84635725
64RPS6KA60.83854914
65MAP3K60.83510680
66DYRK1A0.82969708
67PTK2B0.82847457
68ZAK0.81758025
69PKN10.81280589
70CDK11A0.80712324
71BMPR1B0.79528116
72OXSR10.78377081
73BMPR20.77901411
74MKNK20.77023574
75MAPK120.77019607
76PRKCE0.74887210
77TLK10.74151932
78CCNB10.71787412
79STK110.71180626
80IKBKB0.70791109
81WNK30.70701634
82BCR0.69977820
83TIE10.69758445
84SGK10.68836118
85CSNK1A10.68041613
86TGFBR10.66209305
87FGR0.65647841
88CSK0.64524547
89PRKCI0.63545203
90PRKACG0.62140486
91CAMK10.60962453
92ABL20.60945639
93TYRO30.60451023
94CSNK1A1L0.60018469
95AURKA0.59468342
96MAPK90.59305046
97RET0.59128447
98PRKCZ0.57997189
99RPS6KA20.57674639
100CSNK1G30.57636309
101CAMK1G0.57403106
102ERBB20.56818012
103CAMK1D0.56416004
104ADRBK20.55294748
105SGK30.54592268
106ARAF0.53580256
107MAP3K20.53214663
108PRKD30.53058941
109PRKD20.51812809
110CHUK0.51424326
111INSR0.51079031
112EPHB20.50997098
113PRKCQ0.48846173
114PRKCA0.48828025
115NME10.48119009
116MUSK0.47157856
117FYN0.45985613
118CSNK1G10.45502353
119ERBB40.45387756
120LYN0.45382570
121STK380.45326843
122CAMK2D0.43664346
123DAPK30.43067747
124TNK20.42790691
125STK390.42765975
126PRKCH0.42565013
127FER0.42050426
128MAPK80.41426647
129RAF10.41412040
130GRK70.41056828
131ROCK20.40672180
132ADRBK10.39564320
133RPS6KA30.38858647
134SIK30.38596893
135BRAF0.37591213
136MAP2K20.37348273
137PRKACA0.35988188
138PIK3CA0.35925565
139MAP2K10.35208991
140PRKG10.35170477
141TAOK10.34953091
142FGFR20.33828780
143GSK3B0.33643593
144PRKCB0.30615920

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14856601
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45542518
3Sulfur metabolism_Homo sapiens_hsa009203.40012362
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.25255263
5Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002503.12338335
6Synaptic vesicle cycle_Homo sapiens_hsa047213.09314689
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90466096
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.84902905
9GABAergic synapse_Homo sapiens_hsa047272.82124530
10Morphine addiction_Homo sapiens_hsa050322.75097865
11Circadian entrainment_Homo sapiens_hsa047132.69729880
12Glutamatergic synapse_Homo sapiens_hsa047242.58977267
13Olfactory transduction_Homo sapiens_hsa047402.55558587
14Long-term potentiation_Homo sapiens_hsa047202.51835528
15Taste transduction_Homo sapiens_hsa047422.30955965
16Amphetamine addiction_Homo sapiens_hsa050312.30308509
17Dopaminergic synapse_Homo sapiens_hsa047282.28475841
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14866149
19Serotonergic synapse_Homo sapiens_hsa047262.06686480
20Salivary secretion_Homo sapiens_hsa049702.03770701
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.97668138
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91402553
23Cholinergic synapse_Homo sapiens_hsa047251.90369132
24Insulin secretion_Homo sapiens_hsa049111.88606908
25Long-term depression_Homo sapiens_hsa047301.86558594
26Chemical carcinogenesis_Homo sapiens_hsa052041.84485276
27Nitrogen metabolism_Homo sapiens_hsa009101.82127259
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.81955547
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76783751
30Axon guidance_Homo sapiens_hsa043601.69668934
31Retinol metabolism_Homo sapiens_hsa008301.69187089
32Renin secretion_Homo sapiens_hsa049241.68116623
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66079200
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62607157
35Oxytocin signaling pathway_Homo sapiens_hsa049211.60477399
36Cocaine addiction_Homo sapiens_hsa050301.58809913
37Histidine metabolism_Homo sapiens_hsa003401.58284191
38Gastric acid secretion_Homo sapiens_hsa049711.55134427
39Calcium signaling pathway_Homo sapiens_hsa040201.55060423
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52259802
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49577671
42Gap junction_Homo sapiens_hsa045401.49315245
43Collecting duct acid secretion_Homo sapiens_hsa049661.44948354
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44316148
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35176496
46Starch and sucrose metabolism_Homo sapiens_hsa005001.31092086
47GnRH signaling pathway_Homo sapiens_hsa049121.25419598
48Glycerolipid metabolism_Homo sapiens_hsa005611.24904752
49cAMP signaling pathway_Homo sapiens_hsa040241.24371104
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23582797
51Fat digestion and absorption_Homo sapiens_hsa049751.22354573
52Phototransduction_Homo sapiens_hsa047441.20485433
53Linoleic acid metabolism_Homo sapiens_hsa005911.19085958
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.14090096
55RNA polymerase_Homo sapiens_hsa030201.11379805
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11345587
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10613139
58ErbB signaling pathway_Homo sapiens_hsa040121.09916239
59Estrogen signaling pathway_Homo sapiens_hsa049151.09412215
60Melanogenesis_Homo sapiens_hsa049161.02759829
61Glioma_Homo sapiens_hsa052141.01729846
62Type II diabetes mellitus_Homo sapiens_hsa049301.01148050
63Cardiac muscle contraction_Homo sapiens_hsa042600.99542972
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98357182
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97162005
66Vibrio cholerae infection_Homo sapiens_hsa051100.95429705
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91285548
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.91150436
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89825413
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84138066
71Tryptophan metabolism_Homo sapiens_hsa003800.83337127
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81676484
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81112829
74Dorso-ventral axis formation_Homo sapiens_hsa043200.80813869
75Selenocompound metabolism_Homo sapiens_hsa004500.80075697
76Homologous recombination_Homo sapiens_hsa034400.78767338
77Ras signaling pathway_Homo sapiens_hsa040140.77709523
78MAPK signaling pathway_Homo sapiens_hsa040100.76268226
79Alzheimers disease_Homo sapiens_hsa050100.73839909
80Ether lipid metabolism_Homo sapiens_hsa005650.73267460
81Oocyte meiosis_Homo sapiens_hsa041140.73244289
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.73232863
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72769104
84Choline metabolism in cancer_Homo sapiens_hsa052310.72312606
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.71158506
86Regulation of autophagy_Homo sapiens_hsa041400.69029956
87Pancreatic secretion_Homo sapiens_hsa049720.68161422
88Basal cell carcinoma_Homo sapiens_hsa052170.67863591
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67574679
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67562637
91Insulin resistance_Homo sapiens_hsa049310.67192454
92Sulfur relay system_Homo sapiens_hsa041220.63592008
93TGF-beta signaling pathway_Homo sapiens_hsa043500.63533237
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63387957
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63134112
96Dilated cardiomyopathy_Homo sapiens_hsa054140.62051105
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61604398
98Nucleotide excision repair_Homo sapiens_hsa034200.60298542
99Colorectal cancer_Homo sapiens_hsa052100.58806961
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58295026
101Basal transcription factors_Homo sapiens_hsa030220.57911063
102Oxidative phosphorylation_Homo sapiens_hsa001900.57592356
103Wnt signaling pathway_Homo sapiens_hsa043100.56803627
104Thyroid hormone synthesis_Homo sapiens_hsa049180.55960527
105Endometrial cancer_Homo sapiens_hsa052130.55559194
106Rap1 signaling pathway_Homo sapiens_hsa040150.54910255
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.54498232
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53609545
109VEGF signaling pathway_Homo sapiens_hsa043700.52821323
110Alcoholism_Homo sapiens_hsa050340.51976959
111Renal cell carcinoma_Homo sapiens_hsa052110.51626498
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.50207021
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49371222
114RNA degradation_Homo sapiens_hsa030180.48506381
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46010474
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.45092285
117Glucagon signaling pathway_Homo sapiens_hsa049220.44856601
118One carbon pool by folate_Homo sapiens_hsa006700.44512660
119Parkinsons disease_Homo sapiens_hsa050120.43690239
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43143713
121Melanoma_Homo sapiens_hsa052180.42728319
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40079490
123Fanconi anemia pathway_Homo sapiens_hsa034600.39585730
124Tyrosine metabolism_Homo sapiens_hsa003500.39570401
125Caffeine metabolism_Homo sapiens_hsa002320.39552656
126Butanoate metabolism_Homo sapiens_hsa006500.39158823
127Endocytosis_Homo sapiens_hsa041440.38089809
128Prion diseases_Homo sapiens_hsa050200.37879273
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37396359
130Ovarian steroidogenesis_Homo sapiens_hsa049130.37346959
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36496457
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36341809
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36108967
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35000589
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34790913
136Hedgehog signaling pathway_Homo sapiens_hsa043400.34371962
137Huntingtons disease_Homo sapiens_hsa050160.34282229
138Bile secretion_Homo sapiens_hsa049760.33509998
139Insulin signaling pathway_Homo sapiens_hsa049100.32788164
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32420493
141Hippo signaling pathway_Homo sapiens_hsa043900.32230324
142Inositol phosphate metabolism_Homo sapiens_hsa005620.30924219
143Metabolic pathways_Homo sapiens_hsa011000.30219960
144Type I diabetes mellitus_Homo sapiens_hsa049400.29427070
145Non-small cell lung cancer_Homo sapiens_hsa052230.28526768
146Systemic lupus erythematosus_Homo sapiens_hsa053220.27375196
147Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24936020

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