PCDHA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.82297565
2vocalization behavior (GO:0071625)5.03977304
3behavioral response to nicotine (GO:0035095)5.02795632
4synaptic vesicle exocytosis (GO:0016079)4.76747433
5protein localization to synapse (GO:0035418)4.68326595
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66257104
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48598947
8presynaptic membrane assembly (GO:0097105)4.48494854
9neuron recognition (GO:0008038)4.44518324
10indole-containing compound catabolic process (GO:0042436)4.37133891
11indolalkylamine catabolic process (GO:0046218)4.37133891
12tryptophan catabolic process (GO:0006569)4.37133891
13kynurenine metabolic process (GO:0070189)4.35831101
14neuronal action potential propagation (GO:0019227)4.29515772
15glutamate secretion (GO:0014047)4.28800171
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.23268095
17presynaptic membrane organization (GO:0097090)4.16406182
18indolalkylamine metabolic process (GO:0006586)4.13287007
19neural tube formation (GO:0001841)4.09494005
20regulation of glutamate receptor signaling pathway (GO:1900449)4.07990053
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.07126514
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.02118663
23negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01766979
24glutamate receptor signaling pathway (GO:0007215)4.01446892
25regulation of synaptic vesicle exocytosis (GO:2000300)3.97482344
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.94099854
27axonal fasciculation (GO:0007413)3.91735771
28postsynaptic membrane organization (GO:0001941)3.78225018
29L-fucose catabolic process (GO:0042355)3.77181956
30fucose catabolic process (GO:0019317)3.77181956
31L-fucose metabolic process (GO:0042354)3.77181956
32tryptophan metabolic process (GO:0006568)3.69616521
33neuron-neuron synaptic transmission (GO:0007270)3.68898114
34synaptic transmission, glutamatergic (GO:0035249)3.62162228
35neurotransmitter secretion (GO:0007269)3.61413410
36positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.59964143
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.59032819
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.57230599
39cell migration in hindbrain (GO:0021535)3.53598199
40detection of light stimulus involved in visual perception (GO:0050908)3.53211181
41detection of light stimulus involved in sensory perception (GO:0050962)3.53211181
42positive regulation of synapse assembly (GO:0051965)3.53153314
43response to pheromone (GO:0019236)3.51848088
44regulation of synaptic vesicle transport (GO:1902803)3.43360189
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40858939
46detection of calcium ion (GO:0005513)3.38311513
47regulation of glutamate secretion (GO:0014048)3.36078273
48cellular ketone body metabolic process (GO:0046950)3.35602955
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34695549
50startle response (GO:0001964)3.34151761
51exploration behavior (GO:0035640)3.33740691
52transmission of nerve impulse (GO:0019226)3.31861126
53gamma-aminobutyric acid transport (GO:0015812)3.29014699
54response to histamine (GO:0034776)3.27867108
55regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.27602787
56sulfation (GO:0051923)3.25571997
57neuronal action potential (GO:0019228)3.25116933
58indole-containing compound metabolic process (GO:0042430)3.25113252
59behavioral response to ethanol (GO:0048149)3.25104955
60nonmotile primary cilium assembly (GO:0035058)3.25047494
61neurotransmitter transport (GO:0006836)3.25010973
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24520296
63cilium or flagellum-dependent cell motility (GO:0001539)3.23785954
64synaptic vesicle endocytosis (GO:0048488)3.23776486
65reflex (GO:0060004)3.23027196
66pyrimidine nucleobase catabolic process (GO:0006208)3.21813508
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.20727217
68synapse assembly (GO:0007416)3.20377040
69regulation of postsynaptic membrane potential (GO:0060078)3.20300555
70regulation of respiratory system process (GO:0044065)3.20158924
71protein localization to cilium (GO:0061512)3.19325663
72regulation of hippo signaling (GO:0035330)3.19071995
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18018643
74proline transport (GO:0015824)3.17627612
75synaptic vesicle docking involved in exocytosis (GO:0016081)3.17416581
76regulation of neuronal synaptic plasticity (GO:0048168)3.16549565
77neurotransmitter-gated ion channel clustering (GO:0072578)3.16472273
78negative regulation of neurotransmitter transport (GO:0051589)3.15952610
79synaptic vesicle maturation (GO:0016188)3.15830982
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13445086
81signal peptide processing (GO:0006465)3.12142521
82regulation of synapse structural plasticity (GO:0051823)3.11670912
83long-term synaptic potentiation (GO:0060291)3.10582572
84regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09574729
85dendrite development (GO:0016358)3.07875359
86layer formation in cerebral cortex (GO:0021819)3.07074070
87regulation of vesicle fusion (GO:0031338)3.06969344
88negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06639672
89positive regulation of synapse maturation (GO:0090129)3.05971958
90photoreceptor cell maintenance (GO:0045494)3.03893214
91dendritic spine morphogenesis (GO:0060997)3.01884121
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01486913
93ketone body metabolic process (GO:1902224)2.99605620
94protein K11-linked deubiquitination (GO:0035871)2.98996258
95negative regulation of dendrite morphogenesis (GO:0050774)2.98850825
96behavioral response to cocaine (GO:0048148)2.98785361
97innervation (GO:0060384)2.96565196
98regulation of neurotransmitter secretion (GO:0046928)2.96307549
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.95696773
100negative regulation of translation, ncRNA-mediated (GO:0040033)2.95696773
101regulation of translation, ncRNA-mediated (GO:0045974)2.95696773
102negative regulation of microtubule polymerization (GO:0031115)2.95575579
103serotonin metabolic process (GO:0042428)2.94805956
104primary amino compound metabolic process (GO:1901160)2.94312617
105regulation of posttranscriptional gene silencing (GO:0060147)2.94027939
106regulation of gene silencing by miRNA (GO:0060964)2.94027939
107regulation of gene silencing by RNA (GO:0060966)2.94027939
108negative regulation of mast cell activation (GO:0033004)2.92239522
109regulation of synapse assembly (GO:0051963)2.90970501
110energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90291756
111ATP hydrolysis coupled proton transport (GO:0015991)2.90291756
112cilium morphogenesis (GO:0060271)2.89359329
113cornea development in camera-type eye (GO:0061303)2.89027694
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88745774
115auditory behavior (GO:0031223)2.88355551
116amine catabolic process (GO:0009310)2.88302038
117cellular biogenic amine catabolic process (GO:0042402)2.88302038
118regulation of neurotransmitter levels (GO:0001505)2.88298962
119sensory perception of smell (GO:0007608)2.88297803
120dendrite morphogenesis (GO:0048813)2.88120835
121locomotory exploration behavior (GO:0035641)2.87459102
122cerebellar granule cell differentiation (GO:0021707)2.86874655
123membrane depolarization (GO:0051899)2.86779120
124synaptic vesicle transport (GO:0048489)2.86687384
125establishment of synaptic vesicle localization (GO:0097480)2.86687384
126behavioral defense response (GO:0002209)2.86523480
127behavioral fear response (GO:0001662)2.86523480
128mating behavior (GO:0007617)2.85958290
129membrane depolarization during action potential (GO:0086010)2.84184803
130mechanosensory behavior (GO:0007638)2.83234699
131regulation of synaptic plasticity (GO:0048167)2.83153071
132nucleobase catabolic process (GO:0046113)2.82226369
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.81998445
134negative regulation of dendrite development (GO:2000171)2.81906408
135establishment of protein localization to Golgi (GO:0072600)2.81197384
136regulation of synaptic transmission, GABAergic (GO:0032228)2.81156087
137dopamine transport (GO:0015872)2.80548035
138cerebellar Purkinje cell differentiation (GO:0021702)2.79999108
139cilium organization (GO:0044782)2.79866434
140positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79666509
141synapse organization (GO:0050808)2.78803859
142detection of mechanical stimulus involved in sensory perception (GO:0050974)2.78702725
143inner ear receptor stereocilium organization (GO:0060122)2.77879846
144synaptic transmission (GO:0007268)2.77803618
145chaperone-mediated protein transport (GO:0072321)2.77448753
146learning (GO:0007612)2.77229240
147kidney morphogenesis (GO:0060993)2.76751365
148tachykinin receptor signaling pathway (GO:0007217)2.76600765
149cilium assembly (GO:0042384)2.75561013
150regulation of respiratory gaseous exchange (GO:0043576)2.75302925
151regulation of action potential (GO:0098900)2.69753249
152auditory receptor cell stereocilium organization (GO:0060088)2.68287142
153benzene-containing compound metabolic process (GO:0042537)2.68037905
154oxidative demethylation (GO:0070989)2.66676140
155epithelial cilium movement (GO:0003351)2.66253784
156spinal cord motor neuron differentiation (GO:0021522)2.66125526
157axoneme assembly (GO:0035082)2.61199809
158reciprocal meiotic recombination (GO:0007131)2.56948130
159reciprocal DNA recombination (GO:0035825)2.56948130
160cellular response to sterol (GO:0036315)2.53773635
161retinal cone cell development (GO:0046549)2.53765054
162protein polyglutamylation (GO:0018095)2.53312719
163synaptic transmission, cholinergic (GO:0007271)2.52300925
164central nervous system neuron axonogenesis (GO:0021955)2.52005723
165negative regulation of systemic arterial blood pressure (GO:0003085)2.51828121
166NAD biosynthetic process (GO:0009435)2.51361939
167regulation of pigment cell differentiation (GO:0050932)2.51243907
168cAMP catabolic process (GO:0006198)2.50735817
169cilium movement (GO:0003341)2.49690689
170somite development (GO:0061053)2.49081155
171regulation of collateral sprouting (GO:0048670)2.48883926
172interkinetic nuclear migration (GO:0022027)2.48834083
173positive regulation of oligodendrocyte differentiation (GO:0048714)2.48541779
174embryonic epithelial tube formation (GO:0001838)2.47734944
175positive regulation of developmental pigmentation (GO:0048087)2.47441122
176regulation of sarcomere organization (GO:0060297)2.47317216
177protein K48-linked deubiquitination (GO:0071108)2.45812757
178limb development (GO:0060173)2.45127921
179appendage development (GO:0048736)2.45127921
180limb bud formation (GO:0060174)2.42542716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.32072795
2GBX2_23144817_ChIP-Seq_PC3_Human4.16468334
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94857594
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86401576
5TAF15_26573619_Chip-Seq_HEK293_Human2.86112031
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82779055
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.54230821
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48138599
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48138599
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46905428
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43962238
12REST_21632747_ChIP-Seq_MESCs_Mouse2.40717550
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36908690
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.33339376
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30609072
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.29282625
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24250711
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.22305913
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21447072
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18521603
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18330034
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17720463
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13803904
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.08286687
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04239770
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.95659942
27P300_19829295_ChIP-Seq_ESCs_Human1.91800776
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91725249
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.88935720
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87072739
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.85340727
32AR_21572438_ChIP-Seq_LNCaP_Human1.84250537
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82142120
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.76660787
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76211364
36SMAD4_21799915_ChIP-Seq_A2780_Human1.75687198
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72988085
38PIAS1_25552417_ChIP-Seq_VCAP_Human1.69755691
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.66260994
40VDR_22108803_ChIP-Seq_LS180_Human1.65895725
41RNF2_27304074_Chip-Seq_NSC_Mouse1.65695755
42DROSHA_22980978_ChIP-Seq_HELA_Human1.65671036
43IGF1R_20145208_ChIP-Seq_DFB_Human1.62105442
44FUS_26573619_Chip-Seq_HEK293_Human1.60738994
45ZNF274_21170338_ChIP-Seq_K562_Hela1.60381156
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58636604
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52450255
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51826261
49CBP_20019798_ChIP-Seq_JUKART_Human1.51826261
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51262394
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51260235
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50955762
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.50249976
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49348071
55* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49167166
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43224725
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42693074
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41074368
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40882443
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39578527
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39129725
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38532622
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36252371
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34927706
65TCF4_22108803_ChIP-Seq_LS180_Human1.32660445
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31740427
67AR_25329375_ChIP-Seq_VCAP_Human1.30645370
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29043804
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28571422
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28372040
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.27948614
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.26694469
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26361914
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.26026155
75ER_23166858_ChIP-Seq_MCF-7_Human1.25837461
76STAT3_23295773_ChIP-Seq_U87_Human1.25244298
77IRF1_19129219_ChIP-ChIP_H3396_Human1.24314824
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23044118
79TP53_22573176_ChIP-Seq_HFKS_Human1.22269015
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.20750733
81TP53_16413492_ChIP-PET_HCT116_Human1.19762429
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19636995
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.19245847
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19169440
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18618724
86NANOG_19829295_ChIP-Seq_ESCs_Human1.18191187
87SOX2_19829295_ChIP-Seq_ESCs_Human1.18191187
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17962666
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17287771
90RUNX2_22187159_ChIP-Seq_PCA_Human1.16511395
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16433973
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16429449
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15837731
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15837731
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.15756740
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.15749228
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.15558342
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.13902760
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.13880135
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13750344
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13650233
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12639648
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11763084
104JUN_21703547_ChIP-Seq_K562_Human1.11697643
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.11021524
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10898692
107TCF4_23295773_ChIP-Seq_U87_Human1.10125817
108AHR_22903824_ChIP-Seq_MCF-7_Human1.07807425
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.07467388
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07206763
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.06262853
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06210361
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05092518
114FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04951682
115FOXA1_25329375_ChIP-Seq_VCAP_Human1.04951682
116TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04625389
117BCAT_22108803_ChIP-Seq_LS180_Human1.04076966
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03644292
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02225077
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00666554
121EWS_26573619_Chip-Seq_HEK293_Human1.00122140
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99633738
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.99473330
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.98725814
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.98506037
126* KDM2B_26808549_Chip-Seq_REH_Human0.98286400
127AR_19668381_ChIP-Seq_PC3_Human0.98059763
128TP53_18474530_ChIP-ChIP_U2OS_Human0.97328822
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95708700
130P53_22387025_ChIP-Seq_ESCs_Mouse0.95094898
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94827591
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94201741
133CMYC_18555785_Chip-Seq_ESCs_Mouse0.93354318
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92281482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.93963261
2MP0004859_abnormal_synaptic_plasticity4.14308466
3MP0004270_analgesia3.64260001
4MP0003635_abnormal_synaptic_transmissio3.57232251
5MP0006276_abnormal_autonomic_nervous3.10264449
6MP0001968_abnormal_touch/_nociception3.09210345
7MP0000569_abnormal_digit_pigmentation3.07374611
8MP0009745_abnormal_behavioral_response3.02855089
9MP0002063_abnormal_learning/memory/cond2.96996071
10MP0005423_abnormal_somatic_nervous2.92183913
11MP0002735_abnormal_chemical_nociception2.87186508
12MP0002064_seizures2.81980681
13MP0009046_muscle_twitch2.75135540
14MP0002572_abnormal_emotion/affect_behav2.74946979
15MP0002734_abnormal_mechanical_nocicepti2.66896335
16MP0002736_abnormal_nociception_after2.66717722
17MP0003195_calcinosis2.61853092
18MP0002272_abnormal_nervous_system2.58660129
19MP0001984_abnormal_olfaction2.52407701
20MP0001486_abnormal_startle_reflex2.46047659
21MP0001440_abnormal_grooming_behavior2.42845545
22MP0008877_abnormal_DNA_methylation2.38203033
23MP0002184_abnormal_innervation2.26102453
24MP0002733_abnormal_thermal_nociception2.24758546
25MP0000778_abnormal_nervous_system2.24523912
26MP0001501_abnormal_sleep_pattern2.19356298
27MP0002067_abnormal_sensory_capabilities2.12688952
28MP0001188_hyperpigmentation2.10958236
29MP0001970_abnormal_pain_threshold2.06365895
30MP0002653_abnormal_ependyma_morphology2.05557142
31MP0003646_muscle_fatigue1.96769400
32MP0002557_abnormal_social/conspecific_i1.94900941
33MP0006292_abnormal_olfactory_placode1.91355023
34MP0001529_abnormal_vocalization1.81109629
35MP0004924_abnormal_behavior1.80411413
36MP0005386_behavior/neurological_phenoty1.80411413
37MP0001905_abnormal_dopamine_level1.78737885
38MP0010386_abnormal_urinary_bladder1.74578654
39MP0000427_abnormal_hair_cycle1.74003658
40MP0002837_dystrophic_cardiac_calcinosis1.70502822
41MP0003122_maternal_imprinting1.63794349
42MP0004043_abnormal_pH_regulation1.62256093
43MP0002938_white_spotting1.61315010
44MP0003329_amyloid_beta_deposits1.58881793
45MP0004133_heterotaxia1.58612256
46MP0005645_abnormal_hypothalamus_physiol1.55536485
47MP0004142_abnormal_muscle_tone1.50917454
48MP0004811_abnormal_neuron_physiology1.50708731
49MP0002882_abnormal_neuron_morphology1.50683066
50MP0000955_abnormal_spinal_cord1.47387402
51MP0008872_abnormal_physiological_respon1.46560595
52MP0004742_abnormal_vestibular_system1.44287370
53MP0003879_abnormal_hair_cell1.44012007
54MP0005646_abnormal_pituitary_gland1.39357146
55MP0002066_abnormal_motor_capabilities/c1.36642269
56MP0000383_abnormal_hair_follicle1.36408628
57MP0004858_abnormal_nervous_system1.34512878
58MP0003890_abnormal_embryonic-extraembry1.33953247
59MP0008569_lethality_at_weaning1.32189418
60MP0001986_abnormal_taste_sensitivity1.30697171
61MP0004147_increased_porphyrin_level1.27341122
62MP0005551_abnormal_eye_electrophysiolog1.25553294
63MP0001502_abnormal_circadian_rhythm1.22843246
64MP0002928_abnormal_bile_duct1.20896958
65MP0005394_taste/olfaction_phenotype1.19945903
66MP0005499_abnormal_olfactory_system1.19945903
67MP0008057_abnormal_DNA_replication1.19503243
68MP0009780_abnormal_chondrocyte_physiolo1.17031895
69MP0003787_abnormal_imprinting1.16671301
70MP0002152_abnormal_brain_morphology1.14505760
71MP0004145_abnormal_muscle_electrophysio1.13968284
72MP0002822_catalepsy1.13677206
73MP0002752_abnormal_somatic_nervous1.12596029
74MP0008875_abnormal_xenobiotic_pharmacok1.11488390
75MP0005195_abnormal_posterior_eye1.08307467
76MP0001963_abnormal_hearing_physiology1.06669499
77MP0002234_abnormal_pharynx_morphology1.05845366
78MP0002909_abnormal_adrenal_gland1.05111250
79MP0000631_abnormal_neuroendocrine_gland1.05106241
80MP0003011_delayed_dark_adaptation1.04077882
81MP0002229_neurodegeneration1.03152140
82MP0003121_genomic_imprinting1.03048719
83MP0001485_abnormal_pinna_reflex1.02224521
84MP0005174_abnormal_tail_pigmentation1.01486808
85MP0005377_hearing/vestibular/ear_phenot1.00331887
86MP0003878_abnormal_ear_physiology1.00331887
87MP0002876_abnormal_thyroid_physiology0.99924488
88MP0008789_abnormal_olfactory_epithelium0.97321841
89MP0002751_abnormal_autonomic_nervous0.95084510
90MP0003119_abnormal_digestive_system0.94354863
91MP0000751_myopathy0.92901177
92MP0002638_abnormal_pupillary_reflex0.92702293
93MP0004885_abnormal_endolymph0.91217421
94MP0005171_absent_coat_pigmentation0.88378144
95MP0003634_abnormal_glial_cell0.86689257
96MP0000026_abnormal_inner_ear0.86662775
97MP0003937_abnormal_limbs/digits/tail_de0.86439211
98MP0005084_abnormal_gallbladder_morpholo0.86138118
99MP0006072_abnormal_retinal_apoptosis0.85722263
100MP0005535_abnormal_body_temperature0.85418960
101MP0000647_abnormal_sebaceous_gland0.85169133
102MP0000230_abnormal_systemic_arterial0.84512082
103MP0002069_abnormal_eating/drinking_beha0.83898479
104MP0001324_abnormal_eye_pigmentation0.82955034
105MP0003631_nervous_system_phenotype0.82903866
106MP0004085_abnormal_heartbeat0.82621837
107MP0002102_abnormal_ear_morphology0.82500290
108MP0005389_reproductive_system_phenotype0.82362745
109MP0005085_abnormal_gallbladder_physiolo0.82249202
110MP0001919_abnormal_reproductive_system0.81591967
111MP0002160_abnormal_reproductive_system0.80805025
112MP0003633_abnormal_nervous_system0.80629288
113MP0005409_darkened_coat_color0.79124352
114MP0003698_abnormal_male_reproductive0.78609872
115MP0002095_abnormal_skin_pigmentation0.78433545
116MP0003718_maternal_effect0.77744322
117MP0005167_abnormal_blood-brain_barrier0.77446314
118MP0000538_abnormal_urinary_bladder0.74705640
119MP0001664_abnormal_digestion0.73981562
120MP0003136_yellow_coat_color0.71640233
121MP0003632_abnormal_nervous_system0.71319242
122MP0004484_altered_response_of0.68270711
123MP0003861_abnormal_nervous_system0.67718582
124MP0009379_abnormal_foot_pigmentation0.65045252
125MP0004215_abnormal_myocardial_fiber0.64797147
126MP0008874_decreased_physiological_sensi0.64435216
127MP0000604_amyloidosis0.58878170
128MP0000920_abnormal_myelination0.58423747
129MP0005187_abnormal_penis_morphology0.56983568
130MP0001943_abnormal_respiration0.56871066
131MP0005253_abnormal_eye_physiology0.56192970
132MP0003938_abnormal_ear_development0.55937698
133MP0000013_abnormal_adipose_tissue0.53854072
134MP0003137_abnormal_impulse_conducting0.53545411
135MP0005410_abnormal_fertilization0.52614794
136MP0010770_preweaning_lethality0.52526640
137MP0002082_postnatal_lethality0.52526640
138MP0000372_irregular_coat_pigmentation0.51189157

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.55713829
2Myokymia (HP:0002411)5.18630196
3Atonic seizures (HP:0010819)4.96492311
4Epileptic encephalopathy (HP:0200134)4.91667227
5Focal seizures (HP:0007359)4.90863953
6Febrile seizures (HP:0002373)4.68451810
7Pancreatic cysts (HP:0001737)4.66597166
8Hyperventilation (HP:0002883)4.43137543
9True hermaphroditism (HP:0010459)4.29383592
10Pancreatic fibrosis (HP:0100732)4.26111763
11Abnormality of midbrain morphology (HP:0002418)4.02320396
12Molar tooth sign on MRI (HP:0002419)4.02320396
13Absence seizures (HP:0002121)4.02205631
14Genetic anticipation (HP:0003743)3.92220121
15Dialeptic seizures (HP:0011146)3.77663214
16Visual hallucinations (HP:0002367)3.68489429
17Nephronophthisis (HP:0000090)3.67337420
18Limb dystonia (HP:0002451)3.58279865
19Congenital stationary night blindness (HP:0007642)3.47770981
20Progressive cerebellar ataxia (HP:0002073)3.38418870
21Generalized tonic-clonic seizures (HP:0002069)3.29888482
22Abnormality of the renal medulla (HP:0100957)3.23056514
23Broad-based gait (HP:0002136)3.17428205
24Acute necrotizing encephalopathy (HP:0006965)3.16778723
25Retinal dysplasia (HP:0007973)3.12501123
26Cystic liver disease (HP:0006706)3.10907806
27Abnormality of the renal cortex (HP:0011035)3.08528296
28Attenuation of retinal blood vessels (HP:0007843)3.07101945
29Amblyopia (HP:0000646)3.04088082
30Gait imbalance (HP:0002141)3.01068325
31Hypothermia (HP:0002045)3.00852452
32Chronic hepatic failure (HP:0100626)2.98552599
33Abnormal mitochondria in muscle tissue (HP:0008316)2.87109124
34Progressive macrocephaly (HP:0004481)2.82341847
35Polyphagia (HP:0002591)2.80267361
36Abolished electroretinogram (ERG) (HP:0000550)2.77217452
37Drooling (HP:0002307)2.74087210
38Excessive salivation (HP:0003781)2.74087210
39Abnormal hair whorl (HP:0010721)2.72319859
40Medial flaring of the eyebrow (HP:0010747)2.71713276
41Pheochromocytoma (HP:0002666)2.71003591
42Gaze-evoked nystagmus (HP:0000640)2.62826910
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.62485027
44Failure to thrive in infancy (HP:0001531)2.62257820
45Tubular atrophy (HP:0000092)2.61426335
46Progressive inability to walk (HP:0002505)2.60735778
47Supranuclear gaze palsy (HP:0000605)2.57612178
48Congenital primary aphakia (HP:0007707)2.55803132
49Abnormal ciliary motility (HP:0012262)2.55082501
50Epileptiform EEG discharges (HP:0011182)2.54160294
51Increased corneal curvature (HP:0100692)2.53760521
52Keratoconus (HP:0000563)2.53760521
53Cerebral inclusion bodies (HP:0100314)2.52005638
54Absent speech (HP:0001344)2.51447882
55Sclerocornea (HP:0000647)2.50789711
56Truncal ataxia (HP:0002078)2.49726576
57Neuroendocrine neoplasm (HP:0100634)2.49470729
58Inability to walk (HP:0002540)2.49372720
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.48065491
60Protruding tongue (HP:0010808)2.47814073
61Nephrogenic diabetes insipidus (HP:0009806)2.45340266
62Cerebellar dysplasia (HP:0007033)2.43673901
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42693639
64Abnormality of alanine metabolism (HP:0010916)2.42693639
65Hyperalaninemia (HP:0003348)2.42693639
66Furrowed tongue (HP:0000221)2.41691603
67Poor eye contact (HP:0000817)2.41644668
68Absent/shortened dynein arms (HP:0200106)2.41429288
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.41429288
70EEG with generalized epileptiform discharges (HP:0011198)2.40821204
71Neurofibrillary tangles (HP:0002185)2.40567906
72Acute encephalopathy (HP:0006846)2.40280555
73Genital tract atresia (HP:0001827)2.39922586
74Clumsiness (HP:0002312)2.39343874
75Abnormal eating behavior (HP:0100738)2.38470599
76Fetal akinesia sequence (HP:0001989)2.38410536
77Birth length less than 3rd percentile (HP:0003561)2.38084328
78Abnormal respiratory motile cilium physiology (HP:0012261)2.35557359
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34476241
80Mitochondrial inheritance (HP:0001427)2.32906832
81Fair hair (HP:0002286)2.32563986
82Sensory axonal neuropathy (HP:0003390)2.30912764
83Pendular nystagmus (HP:0012043)2.29775732
84Vaginal atresia (HP:0000148)2.29546392
85Male pseudohermaphroditism (HP:0000037)2.28313212
86Anencephaly (HP:0002323)2.27174255
87Abnormal drinking behavior (HP:0030082)2.27168969
88Polydipsia (HP:0001959)2.27168969
89Patellar aplasia (HP:0006443)2.26982924
90Congenital hepatic fibrosis (HP:0002612)2.26620768
91Dysmetria (HP:0001310)2.24829333
92Hypsarrhythmia (HP:0002521)2.24645861
93Poor suck (HP:0002033)2.24447388
94Termporal pattern (HP:0011008)2.22447357
95Insidious onset (HP:0003587)2.22447357
96Decreased central vision (HP:0007663)2.22213781
97Ankle clonus (HP:0011448)2.21651302
98Anxiety (HP:0000739)2.21198417
99Abnormal respiratory epithelium morphology (HP:0012253)2.19750528
100Abnormal respiratory motile cilium morphology (HP:0005938)2.19750528
101Action tremor (HP:0002345)2.19378400
102Impaired social interactions (HP:0000735)2.19240383
103Abnormal social behavior (HP:0012433)2.19240383
104Large for gestational age (HP:0001520)2.18469678
105Renal cortical cysts (HP:0000803)2.17507907
106Akinesia (HP:0002304)2.17362515
107Exotropia (HP:0000577)2.15600158
108Abnormality of the corticospinal tract (HP:0002492)2.14630857
109Specific learning disability (HP:0001328)2.13845363
110Delusions (HP:0000746)2.13123470
111Bony spicule pigmentary retinopathy (HP:0007737)2.11771709
112Dysdiadochokinesis (HP:0002075)2.11655960
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11039375
114Aplasia/Hypoplasia of the patella (HP:0006498)2.09525267
115Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09143334
116Hypoplasia of the brainstem (HP:0002365)2.09143334
117Hemiparesis (HP:0001269)2.08830789
118Hypoplastic ischia (HP:0003175)2.08113673
119Widely spaced teeth (HP:0000687)2.08111132
120Esotropia (HP:0000565)2.08106641
121Optic nerve hypoplasia (HP:0000609)2.07914165
122Blue irides (HP:0000635)2.06909972
123Decreased circulating renin level (HP:0003351)2.06328912
124Congenital, generalized hypertrichosis (HP:0004540)2.05974127
125Congenital sensorineural hearing impairment (HP:0008527)2.05152703
126Postaxial foot polydactyly (HP:0001830)2.05118287
127Diplopia (HP:0000651)2.02967652
128Abnormality of binocular vision (HP:0011514)2.02967652
129Spastic gait (HP:0002064)2.01792474
130Abnormal biliary tract physiology (HP:0012439)2.00923264
131Bile duct proliferation (HP:0001408)2.00923264
132Depression (HP:0000716)1.98885939
133Optic disc pallor (HP:0000543)1.98639212
134Impaired vibration sensation in the lower limbs (HP:0002166)1.97241243
135Narrow nasal bridge (HP:0000446)1.96441567
136Abnormality of salivation (HP:0100755)1.95067844
137Mutism (HP:0002300)1.94679100
138Stomach cancer (HP:0012126)1.94266051
139Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94178503
140Chorioretinal atrophy (HP:0000533)1.91659818
141Abnormality of the ischium (HP:0003174)1.91123948
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90687246
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.90687246
144Scanning speech (HP:0002168)1.89177785
145Hyperthyroidism (HP:0000836)1.87879488
146Abnormal rod and cone electroretinograms (HP:0008323)1.87032522
147Lissencephaly (HP:0001339)1.86720885
148Hypoventilation (HP:0002791)1.84385901
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83518781
150Abnormality of the labia minora (HP:0012880)1.83513786
151Pachygyria (HP:0001302)1.82960066
152Type II lissencephaly (HP:0007260)1.82927285
153Preaxial hand polydactyly (HP:0001177)1.81679572
154Increased CSF lactate (HP:0002490)1.81095234
155Agitation (HP:0000713)1.81075111
156Intestinal atresia (HP:0011100)1.81028889
157Postaxial hand polydactyly (HP:0001162)1.80763120
158Astigmatism (HP:0000483)1.79732952
159Generalized myoclonic seizures (HP:0002123)1.79011435
160Hypoplasia of the pons (HP:0012110)1.78718362
161Generalized hypopigmentation of hair (HP:0011358)1.78567470
162X-linked dominant inheritance (HP:0001423)1.78506012
163Poor coordination (HP:0002370)1.78145755
164Thickened helices (HP:0000391)1.78092863
165Small hand (HP:0200055)1.77680212
166Dandy-Walker malformation (HP:0001305)1.77189160
167Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77067112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.40912220
2CASK4.40021786
3MARK13.48482068
4NTRK33.36924930
5MAP3K42.96460307
6ACVR1B2.85715597
7MAP3K122.85085610
8MAP2K72.77776550
9INSRR2.74574607
10PNCK2.70687479
11EPHA42.65780039
12CDK192.53939098
13MINK12.41702873
14MAP3K92.23620194
15MAP4K22.20799807
16GRK52.03417583
17GRK11.99169062
18RIPK41.93384052
19MAPK131.93277105
20DAPK21.90154257
21ZAK1.88199583
22MAP2K41.81051239
23NTRK21.72922393
24PLK21.72242645
25NUAK11.69780673
26MKNK21.66418859
27PINK11.65385227
28TAOK31.61497914
29ARAF1.56755419
30UHMK11.55868615
31NTRK11.53271173
32DAPK11.51599855
33PRPF4B1.48552246
34KSR11.45992156
35BMPR21.44721494
36PHKG11.41341124
37PHKG21.41341124
38CSNK1G21.40461560
39OXSR11.39397690
40TNIK1.35884113
41STK38L1.25799073
42CDK51.25297330
43AKT31.24319678
44SIK31.23844481
45SIK21.23470284
46PRKCG1.22799462
47CSNK1G31.22677304
48PAK61.21888665
49CAMK2A1.19979894
50BCR1.12228941
51CCNB11.09268851
52CAMK2B1.09246988
53TLK11.05406004
54CAMKK21.04481452
55TXK1.01208034
56LIMK11.00177379
57STK390.99359516
58NME10.98665190
59DYRK20.98366687
60KSR20.96438829
61IRAK10.95115861
62SGK2230.93821810
63SGK4940.93821810
64TGFBR10.93121901
65BMPR1B0.90408939
66EPHA30.87759396
67SGK20.87581363
68ADRBK20.85496553
69FGR0.83972385
70PIK3CA0.83550383
71CSNK1G10.83324670
72CDK180.80448088
73CDK140.79981631
74PRKCE0.79908599
75ERBB30.79906896
76PAK30.79160175
77DYRK1A0.76952132
78STK30.76259943
79CAMK2D0.75887404
80MKNK10.75723319
81BRAF0.74587528
82PTK2B0.74149402
83CDK150.71913893
84WEE10.70054387
85TRIM280.69397456
86CSNK1A1L0.68946987
87PKN10.68676457
88CAMK2G0.67644275
89MAP3K60.66331591
90CDK11A0.65385503
91MAPKAPK50.63469189
92ROCK20.61672431
93WNK40.60653806
94MAPK150.60377494
95ADRBK10.60068217
96FGFR20.59505981
97MAP3K20.58673938
98BRSK20.58294713
99MAPK120.57099409
100ERBB20.55836387
101WNK30.54941173
102STK160.54475517
103CAMK1D0.51895812
104CAMK1G0.51479016
105CAMKK10.51427311
106MAP2K10.51325262
107GRK70.50106751
108MAPKAPK30.49990541
109FES0.49223640
110RPS6KA20.49190310
111NEK20.49115179
112LATS20.48921884
113TEC0.47783477
114CHUK0.47137827
115OBSCN0.46367217
116FER0.46327330
117PIK3CG0.46055580
118LATS10.45780773
119SGK10.42801716
120RET0.41982344
121MAP2K60.41928419
122RPS6KA50.41805482
123TIE10.41780584
124CSNK1D0.41415389
125CDK30.41220810
126MUSK0.40970119
127STK110.40484245
128PRKACA0.40461885
129MYLK0.39944883
130NLK0.39461178
131PRKCZ0.39281542
132PRKAA10.39081175
133PRKG10.38294697
134CSNK1A10.35887075
135SGK30.35598458
136PRKACB0.35335422
137RAF10.34673992
138PRKCQ0.34225448
139CAMK10.34164771
140PRKAA20.34096987
141VRK10.34001250
142CHEK20.33903094
143MARK20.32800903
144YES10.32707541
145TNK20.31267475
146PLK40.31232000
147PRKCH0.30271411
148PDK40.28577760
149PDK30.28577760

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83849087
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29570966
3Olfactory transduction_Homo sapiens_hsa047402.83387626
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76046543
5Oxidative phosphorylation_Homo sapiens_hsa001902.61140290
6Linoleic acid metabolism_Homo sapiens_hsa005912.60603525
7Collecting duct acid secretion_Homo sapiens_hsa049662.55590975
8GABAergic synapse_Homo sapiens_hsa047272.53392613
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.50304943
10Amphetamine addiction_Homo sapiens_hsa050312.47585086
11Glutamatergic synapse_Homo sapiens_hsa047242.44985971
12Morphine addiction_Homo sapiens_hsa050322.42699860
13Circadian entrainment_Homo sapiens_hsa047132.36580168
14Nitrogen metabolism_Homo sapiens_hsa009102.33829049
15Long-term potentiation_Homo sapiens_hsa047202.28985179
16Serotonergic synapse_Homo sapiens_hsa047262.26225286
17Taste transduction_Homo sapiens_hsa047422.25442119
18Dopaminergic synapse_Homo sapiens_hsa047282.20261405
19Parkinsons disease_Homo sapiens_hsa050122.09679659
20Tryptophan metabolism_Homo sapiens_hsa003801.96157416
21Alzheimers disease_Homo sapiens_hsa050101.92650243
22Insulin secretion_Homo sapiens_hsa049111.85444374
23Selenocompound metabolism_Homo sapiens_hsa004501.82936318
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82219410
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.80672267
26Cocaine addiction_Homo sapiens_hsa050301.76034041
27Caffeine metabolism_Homo sapiens_hsa002321.73404155
28Renin secretion_Homo sapiens_hsa049241.73399103
29ABC transporters_Homo sapiens_hsa020101.72660803
30Cholinergic synapse_Homo sapiens_hsa047251.72383599
31Homologous recombination_Homo sapiens_hsa034401.72348020
32Cardiac muscle contraction_Homo sapiens_hsa042601.70136304
33Salivary secretion_Homo sapiens_hsa049701.68447122
34Vibrio cholerae infection_Homo sapiens_hsa051101.68017439
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66967761
36Long-term depression_Homo sapiens_hsa047301.62130673
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57045799
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47582419
39Gastric acid secretion_Homo sapiens_hsa049711.43688003
40Huntingtons disease_Homo sapiens_hsa050161.42543510
41Phototransduction_Homo sapiens_hsa047441.41745581
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.39281139
43Axon guidance_Homo sapiens_hsa043601.38425176
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37664755
45Calcium signaling pathway_Homo sapiens_hsa040201.34971450
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.34515682
47Oxytocin signaling pathway_Homo sapiens_hsa049211.32858472
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32554672
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32491344
50Fanconi anemia pathway_Homo sapiens_hsa034601.31005883
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29015447
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27104215
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26269532
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24833753
55Basal transcription factors_Homo sapiens_hsa030221.23741794
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18076434
57Propanoate metabolism_Homo sapiens_hsa006401.16430129
58GnRH signaling pathway_Homo sapiens_hsa049121.16047144
59Gap junction_Homo sapiens_hsa045401.15877043
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13177340
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12259358
62Chemical carcinogenesis_Homo sapiens_hsa052041.09504355
63Retinol metabolism_Homo sapiens_hsa008301.07941096
64Glycerolipid metabolism_Homo sapiens_hsa005611.01208876
65cAMP signaling pathway_Homo sapiens_hsa040240.95677882
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95301064
67Arachidonic acid metabolism_Homo sapiens_hsa005900.94374781
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92855458
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91448514
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90228323
71Melanogenesis_Homo sapiens_hsa049160.88361684
72beta-Alanine metabolism_Homo sapiens_hsa004100.88268461
73RNA polymerase_Homo sapiens_hsa030200.87856606
74Histidine metabolism_Homo sapiens_hsa003400.87534328
75ErbB signaling pathway_Homo sapiens_hsa040120.87105461
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85700769
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84301223
78Estrogen signaling pathway_Homo sapiens_hsa049150.84028753
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80370234
80Peroxisome_Homo sapiens_hsa041460.79300949
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.78947016
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.75888866
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74417806
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74314885
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71947148
86RNA degradation_Homo sapiens_hsa030180.69885664
87Rheumatoid arthritis_Homo sapiens_hsa053230.69546988
88Alcoholism_Homo sapiens_hsa050340.68075932
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66367543
90Dorso-ventral axis formation_Homo sapiens_hsa043200.65861599
91Oocyte meiosis_Homo sapiens_hsa041140.65817409
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65547204
93Glioma_Homo sapiens_hsa052140.65298039
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64534729
95MAPK signaling pathway_Homo sapiens_hsa040100.61246561
96Phagosome_Homo sapiens_hsa041450.60162152
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59244189
98Fat digestion and absorption_Homo sapiens_hsa049750.58267250
99Circadian rhythm_Homo sapiens_hsa047100.56691991
100Dilated cardiomyopathy_Homo sapiens_hsa054140.56490556
101Pancreatic secretion_Homo sapiens_hsa049720.56306645
102One carbon pool by folate_Homo sapiens_hsa006700.55673355
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55288453
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53781388
105Ras signaling pathway_Homo sapiens_hsa040140.53576368
106Type II diabetes mellitus_Homo sapiens_hsa049300.52814142
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52253863
108Fatty acid biosynthesis_Homo sapiens_hsa000610.51509531
109Thyroid hormone synthesis_Homo sapiens_hsa049180.51343907
110Hedgehog signaling pathway_Homo sapiens_hsa043400.49610274
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48519258
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.47553128
113Non-homologous end-joining_Homo sapiens_hsa034500.46470404
114Choline metabolism in cancer_Homo sapiens_hsa052310.45976542
115Type I diabetes mellitus_Homo sapiens_hsa049400.42659083
116Basal cell carcinoma_Homo sapiens_hsa052170.42650048
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42285095
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42086529
119Glucagon signaling pathway_Homo sapiens_hsa049220.41402440
120Wnt signaling pathway_Homo sapiens_hsa043100.39025452
121Fatty acid degradation_Homo sapiens_hsa000710.38287821
122Butanoate metabolism_Homo sapiens_hsa006500.37766992
123Prion diseases_Homo sapiens_hsa050200.37727614
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.36969780
125Sphingolipid metabolism_Homo sapiens_hsa006000.36269170
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35905609
127African trypanosomiasis_Homo sapiens_hsa051430.35677420
128Lysine degradation_Homo sapiens_hsa003100.35666968
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35579242
130Regulation of autophagy_Homo sapiens_hsa041400.35414358
131Metabolic pathways_Homo sapiens_hsa011000.34546286
132Renal cell carcinoma_Homo sapiens_hsa052110.33766937
133Asthma_Homo sapiens_hsa053100.33741973
134Ether lipid metabolism_Homo sapiens_hsa005650.33309269
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.30942071
136Ovarian steroidogenesis_Homo sapiens_hsa049130.29908252
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29811412
138VEGF signaling pathway_Homo sapiens_hsa043700.27809830
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25647315
140Melanoma_Homo sapiens_hsa052180.25184177
141Protein export_Homo sapiens_hsa030600.25102160
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24966275
143Rap1 signaling pathway_Homo sapiens_hsa040150.24428109
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.23306616
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19823378
146Endocytosis_Homo sapiens_hsa041440.18312561
147Insulin signaling pathway_Homo sapiens_hsa049100.18253327
148Inositol phosphate metabolism_Homo sapiens_hsa005620.17457282

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