PCDHA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.54191435
2pyrimidine nucleobase catabolic process (GO:0006208)4.14020745
3presynaptic membrane organization (GO:0097090)3.90249964
4presynaptic membrane assembly (GO:0097105)3.87825582
5nucleobase catabolic process (GO:0046113)3.64033001
6G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.36853725
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31173831
8detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29027200
9nonmotile primary cilium assembly (GO:0035058)3.23914515
10response to pheromone (GO:0019236)3.20422615
11epithelial cilium movement (GO:0003351)3.20176970
12neuron cell-cell adhesion (GO:0007158)3.20161417
13gamma-aminobutyric acid transport (GO:0015812)3.08045824
14postsynaptic membrane organization (GO:0001941)3.07386695
15reflex (GO:0060004)3.02213185
16protein localization to cilium (GO:0061512)3.00900638
17startle response (GO:0001964)2.98224674
18calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98185739
19retinal ganglion cell axon guidance (GO:0031290)2.98070848
20L-fucose catabolic process (GO:0042355)2.97072205
21fucose catabolic process (GO:0019317)2.97072205
22L-fucose metabolic process (GO:0042354)2.97072205
23water-soluble vitamin biosynthetic process (GO:0042364)2.92477435
24transmission of nerve impulse (GO:0019226)2.86995906
25cellular ketone body metabolic process (GO:0046950)2.85239181
26intraciliary transport (GO:0042073)2.84134777
27kidney morphogenesis (GO:0060993)2.81356286
28cilium morphogenesis (GO:0060271)2.79165919
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.79053320
30negative regulation of cytosolic calcium ion concentration (GO:0051481)2.78206009
31auditory behavior (GO:0031223)2.77351313
32behavioral response to ethanol (GO:0048149)2.76693418
33protein localization to synapse (GO:0035418)2.76647803
34detection of light stimulus involved in sensory perception (GO:0050962)2.76343478
35detection of light stimulus involved in visual perception (GO:0050908)2.76343478
36proline transport (GO:0015824)2.75863149
37synapse assembly (GO:0007416)2.75616133
38axonal fasciculation (GO:0007413)2.75395721
39cilium movement (GO:0003341)2.73990354
40cilium organization (GO:0044782)2.73824896
41cilium assembly (GO:0042384)2.71172115
42dendritic spine morphogenesis (GO:0060997)2.67559042
43neuronal action potential propagation (GO:0019227)2.66932769
44mechanosensory behavior (GO:0007638)2.65700476
45neural tube formation (GO:0001841)2.65176312
46nephron tubule morphogenesis (GO:0072078)2.62145817
47nephron epithelium morphogenesis (GO:0072088)2.62145817
48neuron recognition (GO:0008038)2.61995803
49adult feeding behavior (GO:0008343)2.61856503
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60620705
51negative regulation of translation, ncRNA-mediated (GO:0040033)2.60620705
52regulation of translation, ncRNA-mediated (GO:0045974)2.60620705
53cornea development in camera-type eye (GO:0061303)2.59656184
54somite rostral/caudal axis specification (GO:0032525)2.59122411
55indolalkylamine metabolic process (GO:0006586)2.59062629
56neuronal action potential (GO:0019228)2.58653858
57photoreceptor cell development (GO:0042461)2.58310534
58glutamate receptor signaling pathway (GO:0007215)2.58284679
59protein polyglutamylation (GO:0018095)2.54358815
60protein complex biogenesis (GO:0070271)2.54137763
61ketone body metabolic process (GO:1902224)2.53460418
62vocalization behavior (GO:0071625)2.51688211
63regulation of action potential (GO:0098900)2.47465082
64limb bud formation (GO:0060174)2.47026001
65axoneme assembly (GO:0035082)2.46618138
66respiratory chain complex IV assembly (GO:0008535)2.44475098
67regulation of glucokinase activity (GO:0033131)2.44104578
68regulation of hexokinase activity (GO:1903299)2.44104578
69neuron fate determination (GO:0048664)2.44063769
70platelet dense granule organization (GO:0060155)2.43358684
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43227911
72synaptic transmission, glutamatergic (GO:0035249)2.42367616
73regulation of neurotransmitter uptake (GO:0051580)2.41506891
74cochlea development (GO:0090102)2.40885286
75inner ear receptor stereocilium organization (GO:0060122)2.38596610
76hindbrain development (GO:0030902)2.38398533
77somite development (GO:0061053)2.37196921
78positive regulation of gastrulation (GO:2000543)2.37184006
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36170105
80mitochondrial respiratory chain complex assembly (GO:0033108)2.36141839
81photoreceptor cell maintenance (GO:0045494)2.35640157
82regulation of collateral sprouting (GO:0048670)2.34535026
83forebrain neuron differentiation (GO:0021879)2.33984705
84regulation of feeding behavior (GO:0060259)2.33197009
85spinal cord motor neuron differentiation (GO:0021522)2.32690592
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.32669809
87behavioral defense response (GO:0002209)2.32206607
88behavioral fear response (GO:0001662)2.32206607
89serotonin metabolic process (GO:0042428)2.32116610
90renal tubule morphogenesis (GO:0061333)2.31898317
91regulation of cilium movement (GO:0003352)2.31320989
92negative regulation of telomere maintenance (GO:0032205)2.29314991
93positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29004467
94C4-dicarboxylate transport (GO:0015740)2.28516201
95neuron-neuron synaptic transmission (GO:0007270)2.28510478
96eye photoreceptor cell development (GO:0042462)2.28406233
97inner ear receptor cell development (GO:0060119)2.28280566
98inositol phosphate catabolic process (GO:0071545)2.27433962
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.27280430
100NADH dehydrogenase complex assembly (GO:0010257)2.27280430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.65601383
2GBX2_23144817_ChIP-Seq_PC3_Human3.33483437
3ZNF274_21170338_ChIP-Seq_K562_Hela3.26357306
4IGF1R_20145208_ChIP-Seq_DFB_Human2.90224222
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.75604227
6VDR_22108803_ChIP-Seq_LS180_Human2.72871339
7TAF15_26573619_Chip-Seq_HEK293_Human2.58036981
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56308393
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50714903
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39923998
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.34322926
12FUS_26573619_Chip-Seq_HEK293_Human2.28732671
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21396433
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.21173635
15P300_19829295_ChIP-Seq_ESCs_Human2.20224133
16EWS_26573619_Chip-Seq_HEK293_Human2.12103891
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04386143
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02775997
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.01169581
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.95084721
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.74510110
22REST_21632747_ChIP-Seq_MESCs_Mouse1.71943683
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70886887
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68057722
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67321574
26ER_23166858_ChIP-Seq_MCF-7_Human1.66827688
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65344591
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64571889
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.64308179
30SMAD4_21799915_ChIP-Seq_A2780_Human1.63915696
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62646901
32RNF2_27304074_Chip-Seq_NSC_Mouse1.58150586
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57256253
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56513916
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54657139
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53763221
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53341398
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53341398
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.52556362
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50286690
41STAT3_23295773_ChIP-Seq_U87_Human1.49867840
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49329307
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48379310
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45476160
45AR_25329375_ChIP-Seq_VCAP_Human1.41098013
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40711456
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39628635
48CBP_20019798_ChIP-Seq_JUKART_Human1.39628635
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39338391
50TCF4_23295773_ChIP-Seq_U87_Human1.36532902
51BCAT_22108803_ChIP-Seq_LS180_Human1.36208235
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35953105
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.35530658
54IRF1_19129219_ChIP-ChIP_H3396_Human1.33537745
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29473747
56* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29396071
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28657078
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28579334
59RUNX2_22187159_ChIP-Seq_PCA_Human1.27971009
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.27159181
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25986396
62TP53_22573176_ChIP-Seq_HFKS_Human1.24152187
63AR_21572438_ChIP-Seq_LNCaP_Human1.23951356
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23261195
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22380416
66TCF4_22108803_ChIP-Seq_LS180_Human1.22304436
67MYC_18940864_ChIP-ChIP_HL60_Human1.21075465
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20839803
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20394715
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.20116081
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18535369
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17804256
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.17067983
74* NANOG_19829295_ChIP-Seq_ESCs_Human1.16170998
75* SOX2_19829295_ChIP-Seq_ESCs_Human1.16170998
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.15228604
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13202736
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.12805791
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12358837
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12327005
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.09833923
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09290588
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.08569078
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08362729
85P53_22387025_ChIP-Seq_ESCs_Mouse1.05650051
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.04940699
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.04064206
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.03078327
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02914047
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.02914047
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02345432
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.01318528
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.00954880
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.00888877
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00233116
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99979770
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99775500
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.97399400
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96873585
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.95525342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern2.99589562
2MP0003787_abnormal_imprinting2.64123905
3MP0008877_abnormal_DNA_methylation2.62542224
4MP0006292_abnormal_olfactory_placode2.17627998
5MP0004133_heterotaxia2.16775083
6MP0002102_abnormal_ear_morphology2.16444555
7MP0006276_abnormal_autonomic_nervous2.16101446
8MP0009046_muscle_twitch2.13894626
9MP0006072_abnormal_retinal_apoptosis2.07809648
10MP0005551_abnormal_eye_electrophysiolog2.03262079
11MP0001529_abnormal_vocalization2.02496624
12MP0000569_abnormal_digit_pigmentation2.00811011
13MP0001968_abnormal_touch/_nociception1.98566120
14MP0003136_yellow_coat_color1.97799549
15MP0009745_abnormal_behavioral_response1.92518160
16MP0000778_abnormal_nervous_system1.90777075
17MP0003195_calcinosis1.85949748
18MP0003122_maternal_imprinting1.85861668
19MP0001984_abnormal_olfaction1.83622786
20MP0002638_abnormal_pupillary_reflex1.80748511
21MP0004885_abnormal_endolymph1.80596352
22MP0000631_abnormal_neuroendocrine_gland1.79474974
23MP0002272_abnormal_nervous_system1.78750162
24MP0005645_abnormal_hypothalamus_physiol1.77213447
25MP0003890_abnormal_embryonic-extraembry1.75761642
26MP0002736_abnormal_nociception_after1.74641465
27MP0001486_abnormal_startle_reflex1.71303980
28MP0005253_abnormal_eye_physiology1.69353303
29MP0002938_white_spotting1.69332336
30MP0005423_abnormal_somatic_nervous1.68929967
31MP0004142_abnormal_muscle_tone1.67799695
32MP0002837_dystrophic_cardiac_calcinosis1.66205408
33MP0005646_abnormal_pituitary_gland1.62473262
34MP0002572_abnormal_emotion/affect_behav1.61790249
35MP0002653_abnormal_ependyma_morphology1.61044369
36MP0003121_genomic_imprinting1.60612490
37MP0003635_abnormal_synaptic_transmissio1.59513226
38MP0002822_catalepsy1.55395526
39MP0002064_seizures1.53069042
40MP0002735_abnormal_chemical_nociception1.53006370
41MP0004270_analgesia1.52725179
42MP0002557_abnormal_social/conspecific_i1.51797496
43MP0001485_abnormal_pinna_reflex1.48951312
44MP0002909_abnormal_adrenal_gland1.47955435
45MP0003011_delayed_dark_adaptation1.45835689
46MP0002063_abnormal_learning/memory/cond1.39793185
47MP0004859_abnormal_synaptic_plasticity1.38433940
48MP0008872_abnormal_physiological_respon1.38319561
49MP0002734_abnormal_mechanical_nocicepti1.38282597
50MP0002184_abnormal_innervation1.35527834
51MP0001188_hyperpigmentation1.35443738
52MP0002067_abnormal_sensory_capabilities1.29893998
53MP0004742_abnormal_vestibular_system1.27218327
54MP0002876_abnormal_thyroid_physiology1.26892552
55MP0002928_abnormal_bile_duct1.22572568
56MP0005386_behavior/neurological_phenoty1.21315114
57MP0004924_abnormal_behavior1.21315114
58MP0001970_abnormal_pain_threshold1.19764495
59MP0002751_abnormal_autonomic_nervous1.18229935
60MP0001986_abnormal_taste_sensitivity1.17639550
61MP0002752_abnormal_somatic_nervous1.15946513
62MP0001501_abnormal_sleep_pattern1.15857830
63MP0008789_abnormal_olfactory_epithelium1.15015791
64MP0000427_abnormal_hair_cycle1.14253257
65MP0000566_synostosis1.14040196
66MP0003283_abnormal_digestive_organ1.13329435
67MP0001293_anophthalmia1.12420236
68MP0003119_abnormal_digestive_system1.11923040
69MP0003937_abnormal_limbs/digits/tail_de1.11920417
70MP0000372_irregular_coat_pigmentation1.11632824
71MP0002234_abnormal_pharynx_morphology1.11558752
72MP0000955_abnormal_spinal_cord1.11492906
73MP0002882_abnormal_neuron_morphology1.06960566
74MP0005195_abnormal_posterior_eye1.05345269
75MP0000049_abnormal_middle_ear1.03858621
76MP0001905_abnormal_dopamine_level1.03442971
77MP0002733_abnormal_thermal_nociception1.03419778
78MP0001502_abnormal_circadian_rhythm1.03400764
79MP0004043_abnormal_pH_regulation1.03268644
80MP0000026_abnormal_inner_ear1.01240701
81MP0005394_taste/olfaction_phenotype1.00876723
82MP0005499_abnormal_olfactory_system1.00876723
83MP0005379_endocrine/exocrine_gland_phen0.95792497
84MP0001440_abnormal_grooming_behavior0.92757302
85MP0004145_abnormal_muscle_electrophysio0.91449626
86MP0005174_abnormal_tail_pigmentation0.91402961
87MP0002160_abnormal_reproductive_system0.90272025
88MP0003938_abnormal_ear_development0.90175026
89MP0005084_abnormal_gallbladder_morpholo0.90095948
90MP0001963_abnormal_hearing_physiology0.86564977
91MP0000516_abnormal_urinary_system0.86420977
92MP0005367_renal/urinary_system_phenotyp0.86420977
93MP0005391_vision/eye_phenotype0.86239968
94MP0002233_abnormal_nose_morphology0.85904698
95MP0008995_early_reproductive_senescence0.85447417
96MP0002163_abnormal_gland_morphology0.85165156
97MP0002152_abnormal_brain_morphology0.84750541
98MP0010386_abnormal_urinary_bladder0.84177999
99MP0003137_abnormal_impulse_conducting0.83605532
100MP0002229_neurodegeneration0.83263072

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.04181105
2Abnormality of midbrain morphology (HP:0002418)4.04181105
3Pancreatic cysts (HP:0001737)3.91234167
4Nephronophthisis (HP:0000090)3.83540039
5Pancreatic fibrosis (HP:0100732)3.81882298
6True hermaphroditism (HP:0010459)3.65284799
7Medial flaring of the eyebrow (HP:0010747)3.43746626
8Abnormality of the renal medulla (HP:0100957)3.24714750
9Gait imbalance (HP:0002141)3.00671715
10Congenital stationary night blindness (HP:0007642)2.96873091
11Limb dystonia (HP:0002451)2.85944407
12Focal motor seizures (HP:0011153)2.85901249
13Congenital primary aphakia (HP:0007707)2.83190057
14Type II lissencephaly (HP:0007260)2.82287608
15Hyperventilation (HP:0002883)2.81862665
16Chronic hepatic failure (HP:0100626)2.77505897
17Genital tract atresia (HP:0001827)2.72815626
18Vaginal atresia (HP:0000148)2.68314190
19Abolished electroretinogram (ERG) (HP:0000550)2.64645573
20Abnormality of the renal cortex (HP:0011035)2.59829378
21Nephrogenic diabetes insipidus (HP:0009806)2.57833239
22Abnormality of the labia minora (HP:0012880)2.57793037
23Broad-based gait (HP:0002136)2.55206008
24Febrile seizures (HP:0002373)2.52271820
25Large for gestational age (HP:0001520)2.50272685
26Cystic liver disease (HP:0006706)2.44019760
27Progressive cerebellar ataxia (HP:0002073)2.38817281
28Sclerocornea (HP:0000647)2.38098457
29Colon cancer (HP:0003003)2.36880373
30Intestinal atresia (HP:0011100)2.33417549
31Hypothermia (HP:0002045)2.30450113
32Focal seizures (HP:0007359)2.28323099
33Pendular nystagmus (HP:0012043)2.25121667
34Agitation (HP:0000713)2.21780642
35Lissencephaly (HP:0001339)2.19271318
36Inability to walk (HP:0002540)2.19127844
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.18542971
38Drooling (HP:0002307)2.16415591
39Renal cortical cysts (HP:0000803)2.12973439
40Attenuation of retinal blood vessels (HP:0007843)2.12109885
41Poor coordination (HP:0002370)2.10516138
42Retinal dysplasia (HP:0007973)2.09543361
43Anencephaly (HP:0002323)2.07691017
44Hemiparesis (HP:0001269)2.06669599
45Chorioretinal atrophy (HP:0000533)2.05124686
46Abnormal drinking behavior (HP:0030082)2.04400368
47Polydipsia (HP:0001959)2.04400368
48Gaze-evoked nystagmus (HP:0000640)2.02306170
49Cerebellar dysplasia (HP:0007033)2.01395907
50Methylmalonic acidemia (HP:0002912)2.01062782
51Tubular atrophy (HP:0000092)1.97934896
52Postaxial hand polydactyly (HP:0001162)1.97581560
53Optic nerve hypoplasia (HP:0000609)1.96717971
54Acute necrotizing encephalopathy (HP:0006965)1.96396540
55Dialeptic seizures (HP:0011146)1.93935066
56Male pseudohermaphroditism (HP:0000037)1.92393218
57Postaxial foot polydactyly (HP:0001830)1.92173419
58Polyphagia (HP:0002591)1.92144899
59Congenital hepatic fibrosis (HP:0002612)1.92090447
60Progressive macrocephaly (HP:0004481)1.90662678
61Epileptic encephalopathy (HP:0200134)1.90621044
62Narrow forehead (HP:0000341)1.90172848
63Aplasia/Hypoplasia of the tibia (HP:0005772)1.89379781
64Excessive salivation (HP:0003781)1.89167600
65Anophthalmia (HP:0000528)1.88855846
66Genetic anticipation (HP:0003743)1.88415201
67Lipid accumulation in hepatocytes (HP:0006561)1.88257844
68Oligodactyly (hands) (HP:0001180)1.87637179
69Mitochondrial inheritance (HP:0001427)1.87616880
70Increased CSF lactate (HP:0002490)1.87302191
71Protruding tongue (HP:0010808)1.86758615
72Increased hepatocellular lipid droplets (HP:0006565)1.85355355
73Septo-optic dysplasia (HP:0100842)1.85005299
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84163758
75Acute encephalopathy (HP:0006846)1.84080637
76Rib fusion (HP:0000902)1.83742436
77Bile duct proliferation (HP:0001408)1.83495477
78Abnormal biliary tract physiology (HP:0012439)1.83495477
79Decreased central vision (HP:0007663)1.82352882
80Pachygyria (HP:0001302)1.80657452
81Furrowed tongue (HP:0000221)1.80068812
82Abnormal pancreas size (HP:0012094)1.79578827
83Bony spicule pigmentary retinopathy (HP:0007737)1.78867066
84Abnormal rod and cone electroretinograms (HP:0008323)1.76985972
85Hypomagnesemia (HP:0002917)1.76695668
86Abnormality of macular pigmentation (HP:0008002)1.76496603
87Abnormal respiratory epithelium morphology (HP:0012253)1.76047613
88Abnormal respiratory motile cilium morphology (HP:0005938)1.76047613
89Polyuria (HP:0000103)1.75449614
90Absent speech (HP:0001344)1.74744646
91Preaxial hand polydactyly (HP:0001177)1.74418002
92Myokymia (HP:0002411)1.73816388
93Specific learning disability (HP:0001328)1.73621279
94Keratoconus (HP:0000563)1.73471770
95Increased corneal curvature (HP:0100692)1.73471770
96Congenital, generalized hypertrichosis (HP:0004540)1.73206695
97Neoplasm of the adrenal cortex (HP:0100641)1.73093605
98Renal hypoplasia (HP:0000089)1.72877087
99Bilateral microphthalmos (HP:0007633)1.72752579
100Bifid tongue (HP:0010297)1.71255158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.28353702
2CASK3.68263536
3WNK33.09578622
4MARK12.40206904
5ADRBK22.36587749
6TNIK2.28422628
7BMPR1B2.27958340
8NUAK12.24406522
9MAP3K42.21438740
10MAP4K22.17306609
11ZAK2.05066612
12PINK11.94130100
13GRK11.83750017
14MKNK21.81058778
15PNCK1.79357734
16MAPK131.78610511
17WNK41.66246483
18DYRK21.64768355
19ACVR1B1.62582075
20MAP2K71.56027750
21INSRR1.54006091
22NTRK31.52621922
23FGFR21.47169188
24TRIM281.47067139
25PAK31.45592707
26CSNK1G21.43885520
27OXSR11.35565343
28BCR1.30592182
29NTRK21.28312218
30CSNK1G11.25847407
31PRKCG1.23333386
32STK391.22834930
33CSNK1G31.18245834
34EPHA41.16456333
35STK38L1.15215310
36TAF11.10094004
37DAPK21.09629058
38PRKCE1.01809392
39VRK11.00129536
40TLK11.00044067
41CSNK1A1L0.98575603
42MKNK10.97953297
43MAP2K40.91680506
44CAMKK20.91082287
45TAOK30.89458176
46MAPK150.80993921
47MAP3K120.80281193
48ERBB30.79543467
49ADRBK10.76625213
50DYRK30.75644569
51PHKG20.75321654
52PHKG10.75321654
53MINK10.73962739
54AKT30.73794027
55CAMK2A0.73440927
56PLK20.71837382
57PLK30.71189886
58MST40.70542123
59BCKDK0.67360675
60CDK190.67288124
61PIK3CA0.66870698
62PASK0.66841890
63DYRK1A0.63918545
64TIE10.63657006
65EPHA30.61242406
66CAMK10.59564508
67STK160.59448821
68SRPK10.58461683
69TGFBR10.58418552
70STK110.58259944
71NME10.55116170
72EPHB20.54478798
73PLK40.52790230
74CAMK1G0.51482580
75PRKACA0.51045764
76NLK0.50918321
77LATS10.50446766
78CSNK1A10.48763162
79VRK20.48522922
80CDK50.48365695
81CSNK1D0.46955422
82TXK0.46647161
83TSSK60.46632653
84CDK30.46405655
85CAMK2D0.45690076
86CSNK1E0.44110066
87MUSK0.43867349
88UHMK10.42418066
89PRKG10.41274658
90SGK20.41078470
91STK30.40918442
92MAPKAPK50.40899978
93ERBB20.40578552
94OBSCN0.40075167
95SGK2230.39780781
96SGK4940.39780781
97PRKCZ0.35782186
98PRKACB0.34738210
99PKN10.34293290
100MAP2K60.34124233

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.15184031
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67583179
3Phototransduction_Homo sapiens_hsa047442.63311039
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.60136473
5Oxidative phosphorylation_Homo sapiens_hsa001902.57707764
6Protein export_Homo sapiens_hsa030602.52918530
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15365738
8Butanoate metabolism_Homo sapiens_hsa006502.11660136
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.04620141
10Parkinsons disease_Homo sapiens_hsa050122.00154145
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95165114
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91293215
13Selenocompound metabolism_Homo sapiens_hsa004501.85986144
14Linoleic acid metabolism_Homo sapiens_hsa005911.76098746
15Taste transduction_Homo sapiens_hsa047421.73283113
16Nitrogen metabolism_Homo sapiens_hsa009101.70972259
17Cardiac muscle contraction_Homo sapiens_hsa042601.69085986
18GABAergic synapse_Homo sapiens_hsa047271.63931983
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62760040
20Morphine addiction_Homo sapiens_hsa050321.59745948
21Glutamatergic synapse_Homo sapiens_hsa047241.56030359
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55504570
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54593933
24Insulin secretion_Homo sapiens_hsa049111.54065522
25Circadian entrainment_Homo sapiens_hsa047131.53703581
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52982388
27Basal transcription factors_Homo sapiens_hsa030221.41872105
28Ether lipid metabolism_Homo sapiens_hsa005651.37845081
29Huntingtons disease_Homo sapiens_hsa050161.35192912
30Alzheimers disease_Homo sapiens_hsa050101.31883374
31Serotonergic synapse_Homo sapiens_hsa047261.30501325
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28597343
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27210295
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27184499
35Dopaminergic synapse_Homo sapiens_hsa047281.27091810
36RNA polymerase_Homo sapiens_hsa030201.25385519
37Propanoate metabolism_Homo sapiens_hsa006401.20464960
38Tryptophan metabolism_Homo sapiens_hsa003801.20327083
39RNA degradation_Homo sapiens_hsa030181.19862853
40Olfactory transduction_Homo sapiens_hsa047401.15063908
41Steroid biosynthesis_Homo sapiens_hsa001001.14979639
42Cocaine addiction_Homo sapiens_hsa050301.12029559
43Collecting duct acid secretion_Homo sapiens_hsa049661.11288214
44Amphetamine addiction_Homo sapiens_hsa050311.10378468
45Caffeine metabolism_Homo sapiens_hsa002321.09795143
46Peroxisome_Homo sapiens_hsa041461.08390222
47Homologous recombination_Homo sapiens_hsa034401.06961090
48Regulation of autophagy_Homo sapiens_hsa041401.05629445
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02152673
50Fanconi anemia pathway_Homo sapiens_hsa034601.00381871
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.99708576
52Basal cell carcinoma_Homo sapiens_hsa052170.94357099
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90760136
54Hedgehog signaling pathway_Homo sapiens_hsa043400.89888391
55Axon guidance_Homo sapiens_hsa043600.88886451
56Circadian rhythm_Homo sapiens_hsa047100.86093177
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82406257
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79004243
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78795991
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78043417
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.77886749
62Retinol metabolism_Homo sapiens_hsa008300.76870551
63Chemical carcinogenesis_Homo sapiens_hsa052040.76294467
64Synaptic vesicle cycle_Homo sapiens_hsa047210.75311423
65Long-term depression_Homo sapiens_hsa047300.73732600
66Salivary secretion_Homo sapiens_hsa049700.72544729
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69852866
68beta-Alanine metabolism_Homo sapiens_hsa004100.68856758
69Calcium signaling pathway_Homo sapiens_hsa040200.68460551
70Ovarian steroidogenesis_Homo sapiens_hsa049130.67826418
71Hippo signaling pathway_Homo sapiens_hsa043900.66726756
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62855967
73Cholinergic synapse_Homo sapiens_hsa047250.60409367
74Non-homologous end-joining_Homo sapiens_hsa034500.59435547
75ABC transporters_Homo sapiens_hsa020100.59209969
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58712071
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58517383
78Fatty acid elongation_Homo sapiens_hsa000620.57923070
79Metabolic pathways_Homo sapiens_hsa011000.57824409
80Purine metabolism_Homo sapiens_hsa002300.56933861
81Fat digestion and absorption_Homo sapiens_hsa049750.55838590
82TGF-beta signaling pathway_Homo sapiens_hsa043500.52421051
83cAMP signaling pathway_Homo sapiens_hsa040240.51361305
84Mineral absorption_Homo sapiens_hsa049780.50088724
85Glycerolipid metabolism_Homo sapiens_hsa005610.48787704
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47544588
87One carbon pool by folate_Homo sapiens_hsa006700.47257987
88Wnt signaling pathway_Homo sapiens_hsa043100.43020430
89Gastric acid secretion_Homo sapiens_hsa049710.42975592
90Histidine metabolism_Homo sapiens_hsa003400.42549525
91Arachidonic acid metabolism_Homo sapiens_hsa005900.42085260
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.41757265
93Vitamin digestion and absorption_Homo sapiens_hsa049770.41669402
94Renin secretion_Homo sapiens_hsa049240.41196203
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40338224
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39591127
97Dorso-ventral axis formation_Homo sapiens_hsa043200.39311844
98Oxytocin signaling pathway_Homo sapiens_hsa049210.38607710
99Fatty acid metabolism_Homo sapiens_hsa012120.37928097
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35933464

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