PCDH7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.71180765
2vocalization behavior (GO:0071625)4.10095088
3synaptic vesicle exocytosis (GO:0016079)4.03951609
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03792395
5presynaptic membrane assembly (GO:0097105)4.00241864
6locomotory exploration behavior (GO:0035641)3.96241486
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93165663
8protein localization to synapse (GO:0035418)3.83080102
9glutamate secretion (GO:0014047)3.81980795
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77309034
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73402931
12regulation of glutamate receptor signaling pathway (GO:1900449)3.70490457
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.69587227
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.65548086
15regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.60474585
16presynaptic membrane organization (GO:0097090)3.53567469
17regulation of synaptic vesicle exocytosis (GO:2000300)3.52311138
18synaptic vesicle maturation (GO:0016188)3.51080717
19neuron recognition (GO:0008038)3.50225508
20neuronal action potential propagation (GO:0019227)3.48643590
21regulation of cell communication by electrical coupling (GO:0010649)3.41244204
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37104339
23axonal fasciculation (GO:0007413)3.35632265
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.34209498
25exploration behavior (GO:0035640)3.33409007
26glutamate receptor signaling pathway (GO:0007215)3.28754367
27postsynaptic membrane organization (GO:0001941)3.26960216
28negative regulation of hormone biosynthetic process (GO:0032353)3.26463035
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26242940
30regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.25523087
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.21688415
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.10876529
33positive regulation of cardiac muscle cell differentiation (GO:2000727)3.10164615
34cerebellar granule cell differentiation (GO:0021707)3.08422639
35cellular sodium ion homeostasis (GO:0006883)3.06836321
36regulation of cardioblast differentiation (GO:0051890)3.05774123
37regulation of synapse structural plasticity (GO:0051823)3.04544453
38negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.03450773
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03097483
40regulation of voltage-gated calcium channel activity (GO:1901385)3.02223563
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.00634589
42dendrite morphogenesis (GO:0048813)3.00354584
43neurotransmitter-gated ion channel clustering (GO:0072578)2.99952927
44regulation of synaptic vesicle transport (GO:1902803)2.98524013
45neuron-neuron synaptic transmission (GO:0007270)2.96117658
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.94980426
47transmission of nerve impulse (GO:0019226)2.94562174
48synaptic transmission, glutamatergic (GO:0035249)2.92451487
49dendritic spine morphogenesis (GO:0060997)2.92138766
50mesenchymal-epithelial cell signaling (GO:0060638)2.91584033
51membrane assembly (GO:0071709)2.89146416
52detection of calcium ion (GO:0005513)2.88852695
53neurotransmitter secretion (GO:0007269)2.87806303
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86588009
55otic vesicle formation (GO:0030916)2.86256842
56regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84173990
57layer formation in cerebral cortex (GO:0021819)2.83261297
58cardiac myofibril assembly (GO:0055003)2.81225608
59negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79433424
60sodium ion export (GO:0071436)2.76886397
61regulation of postsynaptic membrane potential (GO:0060078)2.76879243
62limb bud formation (GO:0060174)2.76402425
63regulation of dendritic spine morphogenesis (GO:0061001)2.74467805
64cell communication by electrical coupling (GO:0010644)2.73896886
65long-term synaptic potentiation (GO:0060291)2.73790976
66regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73354325
67cell migration in hindbrain (GO:0021535)2.72713853
68negative regulation of hormone metabolic process (GO:0032351)2.71839000
69cellular potassium ion homeostasis (GO:0030007)2.71582472
70proline transport (GO:0015824)2.71413730
71positive regulation of synapse assembly (GO:0051965)2.71125272
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.70784791
73cellular response to epinephrine stimulus (GO:0071872)2.70625369
74cardiac chamber formation (GO:0003207)2.68484402
75regulation of synaptic transmission, glutamatergic (GO:0051966)2.68124757
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67062055
77regulation of dendritic spine development (GO:0060998)2.64947270
78regulation of transforming growth factor beta2 production (GO:0032909)2.64653170
79positive regulation of potassium ion transmembrane transport (GO:1901381)2.62559238
80establishment of nucleus localization (GO:0040023)2.62382098
81response to epinephrine (GO:0071871)2.62137383
82regulation of calcium ion transmembrane transport (GO:1903169)2.62102264
83regulation of calcium ion transmembrane transporter activity (GO:1901019)2.62102264
84righting reflex (GO:0060013)2.61072852
85synapse assembly (GO:0007416)2.60774220
86regulation of neuronal synaptic plasticity (GO:0048168)2.60362955
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59977077
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59842034
89regulation of neurotransmitter secretion (GO:0046928)2.59220617
90regulation of vesicle fusion (GO:0031338)2.58644531
91gamma-aminobutyric acid transport (GO:0015812)2.58339979
92activation of protein kinase A activity (GO:0034199)2.58059034
93regulation of cardiac muscle cell differentiation (GO:2000725)2.57043977
94synapse organization (GO:0050808)2.56843139
95regulation of membrane repolarization (GO:0060306)2.56484807
96positive regulation of cardiac muscle tissue development (GO:0055025)2.56088741
97negative chemotaxis (GO:0050919)2.55419755
98membrane depolarization during action potential (GO:0086010)2.53666196
99multicellular organismal signaling (GO:0035637)2.53021235
100cerebellar Purkinje cell differentiation (GO:0021702)2.52993802
101paraxial mesoderm development (GO:0048339)2.52493530
102dorsal/ventral axis specification (GO:0009950)2.52278710
103positive regulation of dendritic spine morphogenesis (GO:0061003)2.52136098
104regulation of synapse assembly (GO:0051963)2.49418467
105positive regulation of membrane potential (GO:0045838)2.49347546
106regulation of relaxation of muscle (GO:1901077)2.48413542
107membrane depolarization (GO:0051899)2.48239562
108regulation of cardiac muscle cell contraction (GO:0086004)2.48167857
109calcium-mediated signaling using intracellular calcium source (GO:0035584)2.47577165
110regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.45974101
111L-amino acid import (GO:0043092)2.45509227
112vesicle transport along microtubule (GO:0047496)2.45295794
113lateral sprouting from an epithelium (GO:0060601)2.45018188
114neuronal ion channel clustering (GO:0045161)2.44931735
115regulation of synaptic plasticity (GO:0048167)2.44879440
116mesenchymal cell differentiation (GO:0048762)2.43818710
117synaptic vesicle endocytosis (GO:0048488)2.42965326
118negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.42665394
119neuron projection extension involved in neuron projection guidance (GO:1902284)2.42207680
120axon extension involved in axon guidance (GO:0048846)2.42207680
121plasma membrane repair (GO:0001778)2.41581447
122negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.41413821
123neurotransmitter transport (GO:0006836)2.41061825
124cell communication involved in cardiac conduction (GO:0086065)2.40944278
125regulation of axon guidance (GO:1902667)2.39769693
126peripheral nervous system axon ensheathment (GO:0032292)2.39702813
127myelination in peripheral nervous system (GO:0022011)2.39702813
128outflow tract septum morphogenesis (GO:0003148)2.38453014
129positive regulation of cardiac muscle tissue growth (GO:0055023)2.37495633
130mesenchyme morphogenesis (GO:0072132)2.37028962
131ventricular cardiac muscle cell action potential (GO:0086005)2.36663919
132striated muscle hypertrophy (GO:0014897)2.35793920
133camera-type eye morphogenesis (GO:0048593)2.34778080
134startle response (GO:0001964)2.33716709
135endocardial cushion morphogenesis (GO:0003203)2.33246003
136notochord development (GO:0030903)2.32695663
137auditory behavior (GO:0031223)2.32645371
138embryonic heart tube development (GO:0035050)2.28590176
139cardiac muscle cell action potential (GO:0086001)2.27992165
140regulation of axon extension involved in axon guidance (GO:0048841)2.27852037
141positive regulation of cardiac muscle cell proliferation (GO:0060045)2.26495355
142regulation of actin filament-based movement (GO:1903115)2.25900866
143apical protein localization (GO:0045176)2.25500442
144positive regulation of heart growth (GO:0060421)2.23556836
145embryonic foregut morphogenesis (GO:0048617)2.22460864
146mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.22183167
147morphogenesis of an epithelial sheet (GO:0002011)2.21951456
148genitalia morphogenesis (GO:0035112)2.20222445
149cardiac right ventricle morphogenesis (GO:0003215)2.19936145
150nucleus localization (GO:0051647)2.19247947
151negative regulation of striated muscle cell apoptotic process (GO:0010664)2.18044332
152desmosome organization (GO:0002934)2.17887407
153retinal ganglion cell axon guidance (GO:0031290)2.16870225
154myofibril assembly (GO:0030239)2.16602706
155atrial septum morphogenesis (GO:0060413)2.16123275
156cerebral cortex radially oriented cell migration (GO:0021799)2.15320603
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.13277028
158cardiac conduction (GO:0061337)2.12620510
159cardiac muscle cell development (GO:0055013)2.12229553
160cardiac ventricle formation (GO:0003211)2.11568586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.65600806
2* GBX2_23144817_ChIP-Seq_PC3_Human3.66841612
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93135550
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92104900
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80296876
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57217324
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57217324
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51400972
9* EZH2_27304074_Chip-Seq_ESCs_Mouse2.44671493
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41894046
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40598019
12TAF15_26573619_Chip-Seq_HEK293_Human2.31719944
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28996741
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.28889931
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27243343
16AR_21572438_ChIP-Seq_LNCaP_Human2.19245079
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13195685
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12395915
19DROSHA_22980978_ChIP-Seq_HELA_Human2.04602462
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.03055003
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93814973
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.93166745
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90915415
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87894825
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83303241
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82353449
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82009042
28* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81341060
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77619576
30REST_21632747_ChIP-Seq_MESCs_Mouse1.76527051
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.69862350
32* PIAS1_25552417_ChIP-Seq_VCAP_Human1.67690192
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.65026266
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.64344818
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62530712
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61972004
37* P300_19829295_ChIP-Seq_ESCs_Human1.60674193
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58628799
39* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57779910
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.57390944
41* SMAD3_21741376_ChIP-Seq_EPCs_Human1.55663187
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53574254
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53090171
44* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51340213
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51272805
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50760257
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49979432
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46912553
49IGF1R_20145208_ChIP-Seq_DFB_Human1.46649740
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45941803
51* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44481794
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.42580752
53FUS_26573619_Chip-Seq_HEK293_Human1.40283944
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.39398619
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37852007
56* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.37747852
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36576040
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33998673
59* REST_18959480_ChIP-ChIP_MESCs_Mouse1.33471659
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32557970
61AHR_22903824_ChIP-Seq_MCF-7_Human1.32399440
62* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31308537
63SOX9_26525672_Chip-Seq_HEART_Mouse1.31112204
64EWS_26573619_Chip-Seq_HEK293_Human1.30353743
65* TP53_18474530_ChIP-ChIP_U2OS_Human1.30262730
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.30181999
67ZNF274_21170338_ChIP-Seq_K562_Hela1.30169826
68* TP53_16413492_ChIP-PET_HCT116_Human1.28900752
69CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28866832
70* AR_25329375_ChIP-Seq_VCAP_Human1.26665570
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26068830
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.25252181
73ER_23166858_ChIP-Seq_MCF-7_Human1.24855450
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23759958
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23316488
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22580605
77* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22085349
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21451431
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20025180
80STAT3_23295773_ChIP-Seq_U87_Human1.19752137
81WT1_19549856_ChIP-ChIP_CCG9911_Human1.19149404
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.18952906
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18451570
84* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17900640
85* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17900640
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17734825
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17046028
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15357251
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14276762
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13788193
91AR_19668381_ChIP-Seq_PC3_Human1.10422517
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09270618
93* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08885083
94* TCF4_23295773_ChIP-Seq_U87_Human1.08359637
95* TRIM28_21343339_ChIP-Seq_HEK293_Human1.08181222
96RNF2_27304074_Chip-Seq_NSC_Mouse1.07585578
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06380442
98* BCAT_22108803_ChIP-Seq_LS180_Human1.06213878
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05642179
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.05026249
101* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04403483
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.03620894
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02478091
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.00788794
105TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00155371
106* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99586991
107ERG_21242973_ChIP-ChIP_JURKAT_Human0.98653733
108VDR_22108803_ChIP-Seq_LS180_Human0.96776071
109* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96458838
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95789452
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.95503340
112JUN_21703547_ChIP-Seq_K562_Human0.95427041
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94225016
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94225016
115SMAD4_21741376_ChIP-Seq_HESCs_Human0.94188211
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94134804
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.93129465
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92556936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.41620315
2MP0003880_abnormal_central_pattern4.35689536
3MP0003635_abnormal_synaptic_transmissio3.11960262
4MP0004270_analgesia3.02687667
5MP0009046_muscle_twitch2.85926850
6MP0009745_abnormal_behavioral_response2.71158915
7MP0002064_seizures2.59236776
8MP0000751_myopathy2.49645722
9MP0002837_dystrophic_cardiac_calcinosis2.48378116
10MP0002063_abnormal_learning/memory/cond2.42946211
11MP0002734_abnormal_mechanical_nocicepti2.31183091
12MP0001968_abnormal_touch/_nociception2.27519635
13MP0001486_abnormal_startle_reflex2.22233379
14MP0002572_abnormal_emotion/affect_behav2.17086115
15MP0002102_abnormal_ear_morphology2.16252714
16MP0002272_abnormal_nervous_system2.12220397
17MP0005248_abnormal_Harderian_gland2.11914978
18MP0005257_abnormal_intraocular_pressure2.09279240
19MP0004215_abnormal_myocardial_fiber2.00639536
20MP0001440_abnormal_grooming_behavior1.95808998
21MP0000778_abnormal_nervous_system1.93114428
22MP0000579_abnormal_nail_morphology1.88870605
23MP0010030_abnormal_orbit_morphology1.84232208
24MP0002736_abnormal_nociception_after1.82300282
25MP0001501_abnormal_sleep_pattern1.78377284
26MP0005423_abnormal_somatic_nervous1.70948756
27MP0009780_abnormal_chondrocyte_physiolo1.70600924
28MP0002067_abnormal_sensory_capabilities1.68010246
29MP0002735_abnormal_chemical_nociception1.67288000
30MP0004084_abnormal_cardiac_muscle1.66893804
31MP0003941_abnormal_skin_development1.66368927
32MP0001984_abnormal_olfaction1.65607036
33MP0000566_synostosis1.65331689
34MP0003890_abnormal_embryonic-extraembry1.63593771
35MP0003937_abnormal_limbs/digits/tail_de1.61691543
36MP0003385_abnormal_body_wall1.61011551
37MP0005171_absent_coat_pigmentation1.60779356
38MP0005386_behavior/neurological_phenoty1.56788465
39MP0004924_abnormal_behavior1.56788465
40MP0004145_abnormal_muscle_electrophysio1.55459567
41MP0001970_abnormal_pain_threshold1.53113596
42MP0004858_abnormal_nervous_system1.51660268
43MP0003329_amyloid_beta_deposits1.50845534
44MP0002184_abnormal_innervation1.47882307
45MP0001529_abnormal_vocalization1.47828296
46MP0003136_yellow_coat_color1.47549573
47MP0002733_abnormal_thermal_nociception1.46896118
48MP0000534_abnormal_ureter_morphology1.45512615
49MP0005623_abnormal_meninges_morphology1.44405298
50MP0002697_abnormal_eye_size1.41808774
51MP0008438_abnormal_cutaneous_collagen1.41221913
52MP0004085_abnormal_heartbeat1.38905870
53MP0004484_altered_response_of1.38693175
54MP0003283_abnormal_digestive_organ1.38510293
55MP0000749_muscle_degeneration1.38407699
56MP0004036_abnormal_muscle_relaxation1.38296522
57MP0003137_abnormal_impulse_conducting1.37834634
58MP0008569_lethality_at_weaning1.34169534
59MP0002972_abnormal_cardiac_muscle1.33504090
60MP0005377_hearing/vestibular/ear_phenot1.33450753
61MP0003878_abnormal_ear_physiology1.33450753
62MP0006276_abnormal_autonomic_nervous1.33102787
63MP0000537_abnormal_urethra_morphology1.32883895
64MP0002233_abnormal_nose_morphology1.28323227
65MP0002557_abnormal_social/conspecific_i1.28115289
66MP0002882_abnormal_neuron_morphology1.25006484
67MP0003122_maternal_imprinting1.24457912
68MP0002822_catalepsy1.23156940
69MP0001905_abnormal_dopamine_level1.22886907
70MP0005187_abnormal_penis_morphology1.22495398
71MP0003942_abnormal_urinary_system1.21652584
72MP0005620_abnormal_muscle_contractility1.21648538
73MP0000462_abnormal_digestive_system1.21556227
74MP0009250_abnormal_appendicular_skeleto1.21536944
75MP0004510_myositis1.21398916
76MP0000920_abnormal_myelination1.20637910
77MP0000955_abnormal_spinal_cord1.20175138
78MP0004811_abnormal_neuron_physiology1.17464303
79MP0002938_white_spotting1.14961611
80MP0001299_abnormal_eye_distance/1.14735669
81MP0001293_anophthalmia1.14151256
82MP0002066_abnormal_motor_capabilities/c1.13736336
83MP0004742_abnormal_vestibular_system1.10752900
84MP0005503_abnormal_tendon_morphology1.09792770
85MP0005330_cardiomyopathy1.09490809
86MP0000762_abnormal_tongue_morphology1.07940845
87MP0003690_abnormal_glial_cell1.07287419
88MP0004233_abnormal_muscle_weight1.06695332
89MP0003935_abnormal_craniofacial_develop1.04988720
90MP0003634_abnormal_glial_cell1.03458321
91MP0000428_abnormal_craniofacial_morphol1.03361165
92MP0008775_abnormal_heart_ventricle1.02914613
93MP0003950_abnormal_plasma_membrane1.02798633
94MP0003755_abnormal_palate_morphology1.02073989
95MP0004142_abnormal_muscle_tone1.01700082
96MP0003119_abnormal_digestive_system1.01199251
97MP0003633_abnormal_nervous_system0.97970909
98MP0005275_abnormal_skin_tensile0.97398011
99MP0006138_congestive_heart_failure0.95523822
100MP0003646_muscle_fatigue0.95418791
101MP0003567_abnormal_fetal_cardiomyocyte0.94841902
102MP0002249_abnormal_larynx_morphology0.94697604
103MP0003938_abnormal_ear_development0.92737312
104MP0001286_abnormal_eye_development0.92691077
105MP0002234_abnormal_pharynx_morphology0.92406689
106MP0002638_abnormal_pupillary_reflex0.92325602
107MP0004885_abnormal_endolymph0.91867723
108MP0005197_abnormal_uvea_morphology0.91777634
109MP0000631_abnormal_neuroendocrine_gland0.89643801
110MP0004087_abnormal_muscle_fiber0.89292743
111MP0009384_cardiac_valve_regurgitation0.88933144
112MP0000049_abnormal_middle_ear0.88731274
113MP0001177_atelectasis0.88460195
114MP0005646_abnormal_pituitary_gland0.87831288
115MP0003861_abnormal_nervous_system0.87435332
116MP0002152_abnormal_brain_morphology0.87110315
117MP0000747_muscle_weakness0.87075387
118MP0002092_abnormal_eye_morphology0.86280584
119MP0003631_nervous_system_phenotype0.86166151
120MP0003879_abnormal_hair_cell0.85840481
121MP0002090_abnormal_vision0.84199441
122MP0005551_abnormal_eye_electrophysiolog0.84013084
123MP0002177_abnormal_outer_ear0.83082907
124MP0000569_abnormal_digit_pigmentation0.82506270
125MP0005394_taste/olfaction_phenotype0.81798272
126MP0005499_abnormal_olfactory_system0.81798272
127MP0002108_abnormal_muscle_morphology0.81787247
128MP0000383_abnormal_hair_follicle0.81428730
129MP0001502_abnormal_circadian_rhythm0.81202599
130MP0004133_heterotaxia0.80322031
131MP0005409_darkened_coat_color0.79987967
132MP0002109_abnormal_limb_morphology0.79976205
133MP0006072_abnormal_retinal_apoptosis0.79308639
134MP0005369_muscle_phenotype0.78973784
135MP0002116_abnormal_craniofacial_bone0.78760667
136MP0002752_abnormal_somatic_nervous0.78253871
137MP0004272_abnormal_basement_membrane0.77960357
138MP0002106_abnormal_muscle_physiology0.77430543
139MP0001485_abnormal_pinna_reflex0.77202130
140MP0005645_abnormal_hypothalamus_physiol0.76280097
141MP0001346_abnormal_lacrimal_gland0.75867100
142MP0002229_neurodegeneration0.75644049
143MP0000026_abnormal_inner_ear0.75168708
144MP0000013_abnormal_adipose_tissue0.75157756
145MP0001544_abnormal_cardiovascular_syste0.75104285
146MP0005385_cardiovascular_system_phenoty0.75104285
147MP0004130_abnormal_muscle_cell0.74650251
148MP0001188_hyperpigmentation0.73937591
149MP0000604_amyloidosis0.73435484
150MP0010386_abnormal_urinary_bladder0.73315786
151MP0005508_abnormal_skeleton_morphology0.73158841

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.77106932
2Focal seizures (HP:0007359)4.51659648
3Atonic seizures (HP:0010819)4.50910314
4Epileptic encephalopathy (HP:0200134)4.29848574
5Myokymia (HP:0002411)3.91917177
6Sudden death (HP:0001699)3.76276409
7Febrile seizures (HP:0002373)3.53115031
8Absence seizures (HP:0002121)3.33330640
9Abnormality of the calf musculature (HP:0001430)3.14522475
10Dialeptic seizures (HP:0011146)3.05496651
11Hyperventilation (HP:0002883)3.04151399
12Progressive cerebellar ataxia (HP:0002073)3.03794243
13Pheochromocytoma (HP:0002666)2.98274365
14Atrial fibrillation (HP:0005110)2.97774411
15Visual hallucinations (HP:0002367)2.96129892
16Degeneration of the lateral corticospinal tracts (HP:0002314)2.94224105
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.94224105
18Broad-based gait (HP:0002136)2.87130548
19Calf muscle hypertrophy (HP:0008981)2.86027956
20Generalized tonic-clonic seizures (HP:0002069)2.85185679
21Primary atrial arrhythmia (HP:0001692)2.84183663
22Muscle hypertrophy of the lower extremities (HP:0008968)2.82593849
23Termporal pattern (HP:0011008)2.70556171
24Insidious onset (HP:0003587)2.70556171
25Abnormality of the corticospinal tract (HP:0002492)2.68877728
26Neuroendocrine neoplasm (HP:0100634)2.68243394
27Syncope (HP:0001279)2.67324132
28Supraventricular tachycardia (HP:0004755)2.64878066
29Prolonged QT interval (HP:0001657)2.61728901
30Supranuclear gaze palsy (HP:0000605)2.59943993
31Supraventricular arrhythmia (HP:0005115)2.58973146
32Lower limb amyotrophy (HP:0007210)2.56658326
33Neurofibrillary tangles (HP:0002185)2.51357976
34Cutaneous finger syndactyly (HP:0010554)2.47493456
35Right ventricular cardiomyopathy (HP:0011663)2.45241012
36Action tremor (HP:0002345)2.44457202
37Preaxial foot polydactyly (HP:0001841)2.42093497
38Gaze-evoked nystagmus (HP:0000640)2.41807920
39Alacrima (HP:0000522)2.34306579
40Aplasia involving bones of the upper limbs (HP:0009823)2.34124170
41Aplasia of the phalanges of the hand (HP:0009802)2.34124170
42Aplasia involving bones of the extremities (HP:0009825)2.34124170
43Excessive salivation (HP:0003781)2.32592622
44Drooling (HP:0002307)2.32592622
45Dysmetria (HP:0001310)2.31786984
46Dysdiadochokinesis (HP:0002075)2.29668848
47Cerebral inclusion bodies (HP:0100314)2.28156892
48Abnormality of the ischium (HP:0003174)2.26987375
49Exercise-induced myalgia (HP:0003738)2.26911935
50Increased circulating renin level (HP:0000848)2.22888121
51Urinary bladder sphincter dysfunction (HP:0002839)2.22146426
52Mixed hearing impairment (HP:0000410)2.21463899
53Amblyopia (HP:0000646)2.20723881
54Sensory axonal neuropathy (HP:0003390)2.19953686
55Absent speech (HP:0001344)2.19541032
56Fetal akinesia sequence (HP:0001989)2.18986428
57Cutaneous syndactyly (HP:0012725)2.18790290
58Abnormality of incisor morphology (HP:0011063)2.18099828
59Partial duplication of the phalanx of hand (HP:0009999)2.15098941
60Hypoplasia of the iris (HP:0007676)2.14882112
61Distal lower limb amyotrophy (HP:0008944)2.11926809
62Partial duplication of thumb phalanx (HP:0009944)2.10521530
63Akinesia (HP:0002304)2.10059948
64Impaired vibration sensation in the lower limbs (HP:0002166)2.09814248
65Truncal ataxia (HP:0002078)2.08913297
66Decreased lacrimation (HP:0000633)2.08603311
67Hyporeflexia of lower limbs (HP:0002600)2.08512323
68Progressive inability to walk (HP:0002505)2.07203226
69Steppage gait (HP:0003376)2.06919123
70Abnormal eating behavior (HP:0100738)2.06255453
71Midline defect of the nose (HP:0004122)2.06238082
72Hyperkalemia (HP:0002153)2.05434957
73Double outlet right ventricle (HP:0001719)2.03507535
74Congenital malformation of the right heart (HP:0011723)2.03507535
75Abnormal EKG (HP:0003115)2.02029821
76Anophthalmia (HP:0000528)2.01013771
77Bundle branch block (HP:0011710)2.00361319
78Aortic dissection (HP:0002647)1.99872406
79Anxiety (HP:0000739)1.99736469
80Poor eye contact (HP:0000817)1.99691632
81Hypoventilation (HP:0002791)1.98934236
82Polyphagia (HP:0002591)1.96184156
83Premature rupture of membranes (HP:0001788)1.95449021
84Ventricular fibrillation (HP:0001663)1.95249199
85Bifid tongue (HP:0010297)1.94990228
86Lower limb muscle weakness (HP:0007340)1.93230909
87Genetic anticipation (HP:0003743)1.92577986
88Scanning speech (HP:0002168)1.90702303
89Coronal craniosynostosis (HP:0004440)1.89530292
90Ventricular arrhythmia (HP:0004308)1.88728811
91Papillary thyroid carcinoma (HP:0002895)1.88468454
92Blue irides (HP:0000635)1.87998213
93Limited hip movement (HP:0008800)1.87733828
94Urinary urgency (HP:0000012)1.86323728
95EMG: myopathic abnormalities (HP:0003458)1.85406487
96Impaired social interactions (HP:0000735)1.85375083
97Abnormal social behavior (HP:0012433)1.85375083
98Spastic gait (HP:0002064)1.84524663
99Gait imbalance (HP:0002141)1.84114101
100Narrow nasal bridge (HP:0000446)1.83994781
101Myotonia (HP:0002486)1.83320076
102Ankle clonus (HP:0011448)1.83195712
103Hepatoblastoma (HP:0002884)1.83106609
104Bradycardia (HP:0001662)1.80973451
105Left ventricular hypertrophy (HP:0001712)1.80572407
106Myelomeningocele (HP:0002475)1.79123422
107Mutism (HP:0002300)1.78270151
108Neoplasm of the peripheral nervous system (HP:0100007)1.76448971
109Limb dystonia (HP:0002451)1.76337482
110Increased variability in muscle fiber diameter (HP:0003557)1.76224771
111Generalized myoclonic seizures (HP:0002123)1.76138548
112Inability to walk (HP:0002540)1.75642791
113Abnormality of salivation (HP:0100755)1.75172343
114Atrophic scars (HP:0001075)1.75143585
115Muscle fiber splitting (HP:0003555)1.74080743
116Exercise-induced muscle cramps (HP:0003710)1.73864792
117Depression (HP:0000716)1.73050651
118Abnormality of binocular vision (HP:0011514)1.70415292
119Diplopia (HP:0000651)1.70415292
120Broad metatarsal (HP:0001783)1.70104136
121Papilledema (HP:0001085)1.70085603
122Vitreoretinal degeneration (HP:0000655)1.68241917
123Genital tract atresia (HP:0001827)1.67492817
124Hemiparesis (HP:0001269)1.67339073
125Protruding tongue (HP:0010808)1.67196892
126Omphalocele (HP:0001539)1.67140634
127Bilateral microphthalmos (HP:0007633)1.67064705
128Ventricular tachycardia (HP:0004756)1.66362519
129Exotropia (HP:0000577)1.65083500
130Vaginal atresia (HP:0000148)1.65042039
131Lipoatrophy (HP:0100578)1.65029527
132Vertebral arch anomaly (HP:0008438)1.64436351
133Epileptiform EEG discharges (HP:0011182)1.64365244
134Absent eyebrow (HP:0002223)1.63944927
135Shallow orbits (HP:0000586)1.63928263
136Volvulus (HP:0002580)1.62933530
137Turricephaly (HP:0000262)1.62417767
138Morphological abnormality of the middle ear (HP:0008609)1.61189872
139Neonatal short-limb short stature (HP:0008921)1.59205143
140Arterial tortuosity (HP:0005116)1.58735022
141Labial hypoplasia (HP:0000066)1.58115013
142Patent foramen ovale (HP:0001655)1.55799598
143Abnormality of the nasolacrimal system (HP:0000614)1.55056458
144Aplasia/Hypoplasia of the tibia (HP:0005772)1.55038245
145Hypoplastic labia majora (HP:0000059)1.54863467
146Shawl scrotum (HP:0000049)1.53769883
147Duplication of thumb phalanx (HP:0009942)1.53737112
148Aortic aneurysm (HP:0004942)1.52894785
149Transposition of the great arteries (HP:0001669)1.51755399
150Abnormal connection of the cardiac segments (HP:0011545)1.51755399
151Abnormal ventriculo-arterial connection (HP:0011563)1.51755399
152Hyperactive renin-angiotensin system (HP:0000841)1.50298956
153Intellectual disability, moderate (HP:0002342)1.49153759
154Abnormality of the lacrimal duct (HP:0011481)1.49027005
155Bell-shaped thorax (HP:0001591)1.47658493
156Abnormal pancreas size (HP:0012094)1.46434101
157Vascular tortuosity (HP:0004948)1.45197966
158Abnormality of the incisor (HP:0000676)1.45062292
159Hypoplastic ischia (HP:0003175)1.44408594
160Renal hypoplasia (HP:0000089)1.44152498
161White forelock (HP:0002211)1.42940814
162Esophageal atresia (HP:0002032)1.42529779
163Decreased circulating renin level (HP:0003351)1.41883274
164Short 4th metacarpal (HP:0010044)1.41638500
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.41638500
166Neoplasm of the heart (HP:0100544)1.41106739
167Abnormality of permanent molar morphology (HP:0011071)1.40454185
168Abnormality of the dental root (HP:0006486)1.40454185
169Taurodontia (HP:0000679)1.40454185
170Overgrowth (HP:0001548)1.40165741
171Abnormality of the labia majora (HP:0012881)1.39901327
172Abnormality of molar (HP:0011077)1.38614959
173Abnormality of molar morphology (HP:0011070)1.38614959
174Mitral valve prolapse (HP:0001634)1.37488139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.81326706
2EPHA43.39230625
3NTRK32.99951023
4MARK12.82062321
5MAP3K42.76667249
6MAP3K92.56785511
7TNIK2.41842020
8MAP2K72.35151282
9PAK62.06200183
10MINK12.03309928
11DAPK21.93449923
12PLK21.93203604
13LATS11.90965509
14PRPF4B1.84478915
15MAP3K121.83369034
16PHKG11.81559945
17PHKG21.81559945
18NTRK11.76030472
19PKN21.72035271
20STK391.69092785
21OXSR11.65418594
22MET1.64725017
23CDK191.64118757
24MAP2K41.63064212
25NTRK21.58613958
26MST1R1.53311984
27MAPK131.49841297
28PDGFRA1.48579495
29PAK31.41209002
30RIPK41.41027017
31OBSCN1.36904892
32STK38L1.36773606
33PNCK1.28786344
34CDK51.27712454
35KSR21.21795400
36CAMK2A1.20200016
37MYLK1.19357018
38FGFR11.16740935
39KSR11.14027088
40TTN1.10123629
41MKNK21.09852087
42LMTK21.09818567
43PIK3CA1.09445492
44NEK11.05607883
45TYRO31.05355917
46DMPK1.04014463
47LATS21.03091885
48FRK1.02419157
49CAMK2D1.01561373
50FLT31.00729510
51WEE10.97163879
52PKN10.95650455
53FES0.95418342
54BCR0.95067248
55PRKCE0.95065174
56WNK10.94553824
57PRKCG0.93371550
58ROCK20.91302792
59PTK2B0.91111193
60UHMK10.90790334
61SGK4940.90519457
62SGK2230.90519457
63PLK40.89928554
64CSNK1A1L0.87455521
65PBK0.87098458
66GRK70.83914547
67MAP3K20.83701437
68ERBB40.83164000
69CAMKK10.82453124
70FGR0.82245303
71GRK50.82146501
72MUSK0.81221594
73DAPK10.81155335
74CAMK2B0.81142523
75BMPR1B0.80884766
76PTK20.79864854
77CDK140.79530989
78CDK180.78289561
79SGK20.78108158
80CSNK1G10.78103490
81ARAF0.78054865
82EPHB20.75768414
83CDK150.75704465
84ROCK10.74082499
85CCNB10.73617273
86MKNK10.72968962
87PDGFRB0.72214912
88DDR20.70656289
89MAP3K130.70000256
90LIMK10.67843936
91CSNK1G20.67773823
92WNK40.67742453
93RET0.66286692
94BMPR20.65630927
95PDK20.65210686
96FGFR20.64455118
97CAMK10.63793966
98SGK10.63221398
99FER0.62371034
100CDK11A0.62070499
101PRKCH0.61698198
102MARK20.61076224
103SIK20.60197558
104MAPKAPK50.60195112
105STK110.59534442
106PINK10.58816742
107CAMK1D0.58393792
108NEK60.58191894
109DAPK30.58093828
110WNK30.57757224
111AKT30.57682109
112CAMKK20.57159460
113CAMK1G0.56462403
114PDPK10.55913329
115CSNK1G30.55199558
116ADRBK10.54593908
117CAMK2G0.53751769
118MAP2K10.53508182
119PRKD30.53400929
120STK30.52361611
121STK380.51994968
122SGK30.51790345
123PAK20.51610682
124FYN0.50712162
125CAMK40.48901452
126CDC42BPA0.48845457
127ERBB30.47375146
128PRKACB0.47026883
129MAPK120.46900028
130DYRK1A0.44954910
131PRKG10.44844932
132NLK0.44257621
133MAPK100.40878204
134RPS6KA30.40156175
135ICK0.38926478

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.98583640
2Synaptic vesicle cycle_Homo sapiens_hsa047212.65038570
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32204492
4Circadian entrainment_Homo sapiens_hsa047132.20880909
5Olfactory transduction_Homo sapiens_hsa047402.20295897
6GABAergic synapse_Homo sapiens_hsa047272.10131832
7Glutamatergic synapse_Homo sapiens_hsa047242.04169078
8Morphine addiction_Homo sapiens_hsa050322.03273145
9Long-term potentiation_Homo sapiens_hsa047201.97368066
10Cardiac muscle contraction_Homo sapiens_hsa042601.94475325
11Hippo signaling pathway_Homo sapiens_hsa043901.90524411
12Dilated cardiomyopathy_Homo sapiens_hsa054141.90475168
13Collecting duct acid secretion_Homo sapiens_hsa049661.89672423
14Salivary secretion_Homo sapiens_hsa049701.83880482
15Amphetamine addiction_Homo sapiens_hsa050311.82614382
16Dopaminergic synapse_Homo sapiens_hsa047281.76602347
17Basal cell carcinoma_Homo sapiens_hsa052171.76568791
18Renin secretion_Homo sapiens_hsa049241.75705247
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75701588
20Cholinergic synapse_Homo sapiens_hsa047251.70061772
21Serotonergic synapse_Homo sapiens_hsa047261.65865109
22Gastric acid secretion_Homo sapiens_hsa049711.62335027
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61716391
24Axon guidance_Homo sapiens_hsa043601.60590165
25Long-term depression_Homo sapiens_hsa047301.59741109
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58599497
27Oxidative phosphorylation_Homo sapiens_hsa001901.54374010
28Calcium signaling pathway_Homo sapiens_hsa040201.51704847
29Adherens junction_Homo sapiens_hsa045201.50692485
30Taste transduction_Homo sapiens_hsa047421.48766746
31TGF-beta signaling pathway_Homo sapiens_hsa043501.44300118
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43246383
33Insulin secretion_Homo sapiens_hsa049111.42778309
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39505767
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33730985
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33422484
37Alzheimers disease_Homo sapiens_hsa050101.32217827
38Protein digestion and absorption_Homo sapiens_hsa049741.31178093
39GnRH signaling pathway_Homo sapiens_hsa049121.30932400
40Circadian rhythm_Homo sapiens_hsa047101.24363567
41Vibrio cholerae infection_Homo sapiens_hsa051101.24241018
42Gap junction_Homo sapiens_hsa045401.23374952
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22159433
44Cocaine addiction_Homo sapiens_hsa050301.20510009
45cAMP signaling pathway_Homo sapiens_hsa040241.15576446
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15269706
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15075608
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13140540
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12667333
50Parkinsons disease_Homo sapiens_hsa050121.12564539
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10862492
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.10023078
53ErbB signaling pathway_Homo sapiens_hsa040121.02714523
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02263250
55Melanogenesis_Homo sapiens_hsa049161.00907317
56Glioma_Homo sapiens_hsa052140.98963803
57Estrogen signaling pathway_Homo sapiens_hsa049150.96345470
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94759269
59Type II diabetes mellitus_Homo sapiens_hsa049300.93416467
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93077493
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90027110
62Phototransduction_Homo sapiens_hsa047440.81908242
63Rheumatoid arthritis_Homo sapiens_hsa053230.80238574
64Dorso-ventral axis formation_Homo sapiens_hsa043200.80033906
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.76892004
66MAPK signaling pathway_Homo sapiens_hsa040100.76474726
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74803101
68Renal cell carcinoma_Homo sapiens_hsa052110.72268940
69MicroRNAs in cancer_Homo sapiens_hsa052060.71080665
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70767906
71Ras signaling pathway_Homo sapiens_hsa040140.70199688
72ECM-receptor interaction_Homo sapiens_hsa045120.70030251
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69751235
74Pathways in cancer_Homo sapiens_hsa052000.69630346
75Huntingtons disease_Homo sapiens_hsa050160.68429704
76Focal adhesion_Homo sapiens_hsa045100.67636593
77Small cell lung cancer_Homo sapiens_hsa052220.67003805
78Phagosome_Homo sapiens_hsa041450.64097519
79Alcoholism_Homo sapiens_hsa050340.63770329
80Inositol phosphate metabolism_Homo sapiens_hsa005620.62715345
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.62509063
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61519448
83Rap1 signaling pathway_Homo sapiens_hsa040150.61041691
84Choline metabolism in cancer_Homo sapiens_hsa052310.60274150
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59771956
86Melanoma_Homo sapiens_hsa052180.59673727
87Pancreatic secretion_Homo sapiens_hsa049720.59409091
88Vitamin B6 metabolism_Homo sapiens_hsa007500.59219952
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57767137
90Lysine degradation_Homo sapiens_hsa003100.55609165
91Fatty acid biosynthesis_Homo sapiens_hsa000610.55203811
92Tight junction_Homo sapiens_hsa045300.54456391
93Wnt signaling pathway_Homo sapiens_hsa043100.53744559
94Ovarian steroidogenesis_Homo sapiens_hsa049130.52396052
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49344531
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48870955
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48373852
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.47802431
99Colorectal cancer_Homo sapiens_hsa052100.47494886
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47102007
101VEGF signaling pathway_Homo sapiens_hsa043700.47066526
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46595952
103Thyroid hormone synthesis_Homo sapiens_hsa049180.45910519
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45362941
105Glucagon signaling pathway_Homo sapiens_hsa049220.45091252
106Oocyte meiosis_Homo sapiens_hsa041140.44799561
107Proteoglycans in cancer_Homo sapiens_hsa052050.44774146
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44485650
109Amoebiasis_Homo sapiens_hsa051460.43993938
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41978746
111African trypanosomiasis_Homo sapiens_hsa051430.41530775
112Platelet activation_Homo sapiens_hsa046110.40964457
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40389020
114Bile secretion_Homo sapiens_hsa049760.40209475
115Endocytosis_Homo sapiens_hsa041440.40094029
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39245319
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39100958
118Insulin signaling pathway_Homo sapiens_hsa049100.38785066
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38325868
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.37989861
121Endometrial cancer_Homo sapiens_hsa052130.37277631
122Prion diseases_Homo sapiens_hsa050200.36688300
123AMPK signaling pathway_Homo sapiens_hsa041520.36426373
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36000150
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35241626
126Salmonella infection_Homo sapiens_hsa051320.34310061
127Hedgehog signaling pathway_Homo sapiens_hsa043400.32690343

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