PCBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)4.84835806
2DNA unwinding involved in DNA replication (GO:0006268)4.75206718
3viral transcription (GO:0019083)4.74709184
4translational termination (GO:0006415)4.61452542
5histone H3-K36 demethylation (GO:0070544)4.35491599
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.27117980
7pre-miRNA processing (GO:0031054)4.12116311
8nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10426957
9nuclear pore organization (GO:0006999)4.06208169
10translational elongation (GO:0006414)4.03193487
11nuclear pore complex assembly (GO:0051292)4.00834699
12negative regulation of RNA splicing (GO:0033119)3.99480311
13regulation of histone H3-K27 methylation (GO:0061085)3.99367658
14protein localization to kinetochore (GO:0034501)3.97969584
15formation of translation preinitiation complex (GO:0001731)3.95261809
16translational initiation (GO:0006413)3.94127133
17negative regulation of mRNA processing (GO:0050686)3.84194654
18ribosomal small subunit assembly (GO:0000028)3.81222882
19mRNA stabilization (GO:0048255)3.80141081
20RNA stabilization (GO:0043489)3.80141081
21mitotic nuclear envelope disassembly (GO:0007077)3.78064484
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.69299007
23regulation of posttranscriptional gene silencing (GO:0060147)3.68603648
24regulation of gene silencing by miRNA (GO:0060964)3.68603648
25regulation of gene silencing by RNA (GO:0060966)3.68603648
26mitotic sister chromatid cohesion (GO:0007064)3.68459907
27negative regulation of mRNA metabolic process (GO:1903312)3.64119891
28protein targeting to ER (GO:0045047)3.63542579
29nucleosome disassembly (GO:0006337)3.60602460
30protein-DNA complex disassembly (GO:0032986)3.60602460
31cotranslational protein targeting to membrane (GO:0006613)3.58401099
32regulation of nucleobase-containing compound transport (GO:0032239)3.57190634
33membrane disassembly (GO:0030397)3.56805532
34nuclear envelope disassembly (GO:0051081)3.56805532
35viral life cycle (GO:0019058)3.54216763
36cellular protein complex disassembly (GO:0043624)3.54192641
37ribosomal small subunit biogenesis (GO:0042274)3.53287834
38maturation of SSU-rRNA (GO:0030490)3.48845871
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46939670
40protein complex disassembly (GO:0043241)3.43570898
41cell-substrate adherens junction assembly (GO:0007045)3.43254121
42focal adhesion assembly (GO:0048041)3.43254121
43folic acid-containing compound biosynthetic process (GO:0009396)3.42961894
44protein localization to chromosome, centromeric region (GO:0071459)3.37314517
45adherens junction assembly (GO:0034333)3.37090198
46negative regulation of erythrocyte differentiation (GO:0045647)3.37075294
47regulation of NFAT protein import into nucleus (GO:0051532)3.35439023
48cellular response to epidermal growth factor stimulus (GO:0071364)3.33543330
49glucocorticoid receptor signaling pathway (GO:0042921)3.32141815
503-UTR-mediated mRNA stabilization (GO:0070935)3.31217054
51protein localization to endoplasmic reticulum (GO:0070972)3.29454365
52regulation of translational fidelity (GO:0006450)3.28507159
53planar cell polarity pathway involved in neural tube closure (GO:0090179)3.23963269
54regulation of stem cell maintenance (GO:2000036)3.20980122
55apoptotic process involved in morphogenesis (GO:0060561)3.19883334
56regulation of RNA export from nucleus (GO:0046831)3.19073387
57sister chromatid segregation (GO:0000819)3.19063025
58dosage compensation (GO:0007549)3.16645846
59DNA strand elongation involved in DNA replication (GO:0006271)3.16602041
60chromatin assembly (GO:0031497)3.14802849
61mitotic sister chromatid segregation (GO:0000070)3.14440738
62macromolecular complex disassembly (GO:0032984)3.13686196
63protein complex localization (GO:0031503)3.10356212
64DNA replication initiation (GO:0006270)3.09453260
65negative regulation of histone methylation (GO:0031061)3.09205665
66paraxial mesoderm development (GO:0048339)3.08978777
67DNA duplex unwinding (GO:0032508)3.07936787
68nuclear-transcribed mRNA catabolic process (GO:0000956)3.07341178
69peptidyl-lysine dimethylation (GO:0018027)3.06415498
70mannose metabolic process (GO:0006013)3.06094976
71DNA geometric change (GO:0032392)3.04974686
72mRNA cleavage (GO:0006379)3.04932297
73regulation of sister chromatid cohesion (GO:0007063)3.03775239
74regulation of mRNA stability (GO:0043488)3.02824235
75DNA replication-dependent nucleosome assembly (GO:0006335)2.99343170
76DNA replication-dependent nucleosome organization (GO:0034723)2.99343170
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97736813
78establishment of apical/basal cell polarity (GO:0035089)2.97403280
79embryonic eye morphogenesis (GO:0048048)2.96447645
80positive regulation of chromosome segregation (GO:0051984)2.96433262
81DNA strand elongation (GO:0022616)2.95208075
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94592449
83response to epidermal growth factor (GO:0070849)2.94544040
84peptidyl-arginine omega-N-methylation (GO:0035247)2.93112419
85nuclear envelope organization (GO:0006998)2.93097079
86mRNA catabolic process (GO:0006402)2.92159951
87epithelial cell differentiation involved in prostate gland development (GO:0060742)2.91939516
88stress granule assembly (GO:0034063)2.91693051
89intracellular estrogen receptor signaling pathway (GO:0030520)2.91525349
90positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.91474650
91histone lysine demethylation (GO:0070076)2.91473256
92trophectodermal cell differentiation (GO:0001829)2.91303412
93RNA catabolic process (GO:0006401)2.90742138
94protein export from nucleus (GO:0006611)2.90579643
95regulation of histone H3-K9 methylation (GO:0051570)2.90418251
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89255474
97ribosomal large subunit biogenesis (GO:0042273)2.88561066
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.88232888
99gene silencing by RNA (GO:0031047)2.87038181
100* mRNA splicing, via spliceosome (GO:0000398)2.85938327
101* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85938327
102* RNA splicing, via transesterification reactions (GO:0000375)2.84072088
103mitotic chromosome condensation (GO:0007076)2.84014397
104pore complex assembly (GO:0046931)2.83855153
105embryonic process involved in female pregnancy (GO:0060136)2.83367058
106termination of RNA polymerase II transcription (GO:0006369)2.83203101
107regulation of RNA stability (GO:0043487)2.81403916
108alternative mRNA splicing, via spliceosome (GO:0000380)2.80788980
109barbed-end actin filament capping (GO:0051016)2.80589333
110regulation of early endosome to late endosome transport (GO:2000641)2.80020743
111negative regulation of cell size (GO:0045792)2.78388859
112embryonic camera-type eye morphogenesis (GO:0048596)2.76940477
113histone H2A monoubiquitination (GO:0035518)2.75812048
114negative regulation of fatty acid transport (GO:2000192)2.74059135
115IMP biosynthetic process (GO:0006188)2.73923360
116histone demethylation (GO:0016577)2.73761044
117regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72338671
118maternal placenta development (GO:0001893)2.71589592
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70552538
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.68427445
121positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.68023808
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.68023808
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.68023808
124negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.67926543
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.67122829
126regulation of hippo signaling (GO:0035330)2.65422875
127protein localization to chromosome (GO:0034502)2.65221526
128cytoplasmic mRNA processing body assembly (GO:0033962)2.64987368
129telomere maintenance via semi-conservative replication (GO:0032201)2.64265435
130peptidyl-arginine methylation (GO:0018216)2.64042058
131peptidyl-arginine N-methylation (GO:0035246)2.64042058
132polarized epithelial cell differentiation (GO:0030859)2.63928007
133gene silencing (GO:0016458)2.63057310
134corticosteroid receptor signaling pathway (GO:0031958)2.62513260
135regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.62426111
136DNA topological change (GO:0006265)2.62260606
137protein retention in ER lumen (GO:0006621)2.61007811
138NLS-bearing protein import into nucleus (GO:0006607)2.60991968
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.58134419
140regulation of chromatin binding (GO:0035561)2.57985863
141positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57665147
142cortical actin cytoskeleton organization (GO:0030866)2.56923997
143regulation of ARF GTPase activity (GO:0032312)2.56737032
144regulation of glucose import in response to insulin stimulus (GO:2001273)2.56480469
145TOR signaling (GO:0031929)2.53132882
146cellular protein complex localization (GO:0034629)2.52761471
147histone H3-K9 demethylation (GO:0033169)2.52449385
148Golgi transport vesicle coating (GO:0048200)2.51122047
149COPI coating of Golgi vesicle (GO:0048205)2.51122047
150positive regulation of gene expression, epigenetic (GO:0045815)2.49350598
151negative regulation of striated muscle cell apoptotic process (GO:0010664)2.48526801
152poly(A)+ mRNA export from nucleus (GO:0016973)2.43464048
153RNA localization (GO:0006403)2.43347657
154regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.42756416
155positive regulation of DNA-dependent DNA replication (GO:2000105)2.42181977
156insulin-like growth factor receptor signaling pathway (GO:0048009)2.42041623
157protein dealkylation (GO:0008214)2.41897845
158protein demethylation (GO:0006482)2.41897845
159eye morphogenesis (GO:0048592)2.41591537
160negative regulation of striated muscle cell differentiation (GO:0051154)2.39551125
161peptidyl-threonine modification (GO:0018210)2.39084159
162chromosome condensation (GO:0030261)2.37942531
163establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35290415
164cytoskeletal anchoring at plasma membrane (GO:0007016)2.34694152
165definitive hemopoiesis (GO:0060216)2.33305302
166face development (GO:0060324)2.32733559
167response to laminar fluid shear stress (GO:0034616)2.31248516
168negative regulation of DNA repair (GO:0045738)2.29553466
169regulation of response to osmotic stress (GO:0047484)2.29552185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.36221704
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.58470220
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.55876858
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.42970882
5MYC_22102868_ChIP-Seq_BL_Human3.15275098
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11719562
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91616503
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80876279
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78535516
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52391238
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09660498
12LXR_22292898_ChIP-Seq_THP-1_Human2.07516430
13XRN2_22483619_ChIP-Seq_HELA_Human2.06222822
14VDR_21846776_ChIP-Seq_THP-1_Human2.05905448
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04842267
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92977814
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92977814
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92977814
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87782965
20AR_21909140_ChIP-Seq_LNCAP_Human1.87395505
21KDM2B_26808549_Chip-Seq_K562_Human1.84670208
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.83829651
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79297309
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.77842997
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75271873
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74998450
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73851996
28* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71396283
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69138593
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67326003
31TCF7_22412390_ChIP-Seq_EML_Mouse1.65821688
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58205078
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57823607
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55098001
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54140222
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53642752
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53404441
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53202503
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52798545
40KDM2B_26808549_Chip-Seq_DND41_Human1.52223644
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52194947
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.50746308
43* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50479341
44TTF2_22483619_ChIP-Seq_HELA_Human1.49003322
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.48513255
46CIITA_25753668_ChIP-Seq_RAJI_Human1.47755203
47CREB1_26743006_Chip-Seq_LNCaP_Human1.46716035
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45966631
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45795330
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.44490840
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43288028
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.42881326
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42877956
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42658161
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42462824
56ZNF263_19887448_ChIP-Seq_K562_Human1.42448815
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39266809
58* KDM5A_27292631_Chip-Seq_BREAST_Human1.37787177
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37778069
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37253684
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36607423
62* UTX_26944678_Chip-Seq_JUKART_Human1.34100334
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33009675
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32603569
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30969770
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30939478
67MAF_26560356_Chip-Seq_TH1_Human1.30037215
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29759414
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29615942
70* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26618312
71* CHD1_26751641_Chip-Seq_LNCaP_Human1.26382283
72EST1_17652178_ChIP-ChIP_JURKAT_Human1.24689682
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24665762
74* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24350454
75NANOG_21062744_ChIP-ChIP_HESCs_Human1.24291972
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23964219
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23855976
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21127097
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21092402
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20655367
81TFEB_21752829_ChIP-Seq_HELA_Human1.20540453
82* ETS1_20019798_ChIP-Seq_JURKAT_Human1.20134789
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19920849
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19059257
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19006684
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18753654
87* ATF3_27146783_Chip-Seq_COLON_Human1.18598733
88NCOR1_26117541_ChIP-Seq_K562_Human1.17876713
89SMC4_20622854_ChIP-Seq_HELA_Human1.17509398
90* DCP1A_22483619_ChIP-Seq_HELA_Human1.16938537
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15734327
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14842440
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14469396
94SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14017217
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13986339
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13317386
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.12803680
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.12735491
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12442762
100RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10326769
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09619088
102SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09585315
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08805704
104* GABP_19822575_ChIP-Seq_HepG2_Human1.07911889
105* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07837915
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07284267
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07034002
108KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06477381
109SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05513497
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05051498
111* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04362876
112* CLOCK_20551151_ChIP-Seq_293T_Human1.04159904
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.03051557
114RACK7_27058665_Chip-Seq_MCF-7_Human1.02841204
115* VDR_24763502_ChIP-Seq_THP-1_Human1.02020341
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.01889842
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01698405
118* VDR_23849224_ChIP-Seq_CD4+_Human1.01292020
119* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01214246
120* FOXP3_21729870_ChIP-Seq_TREG_Human1.00860130
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.00822023
122* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99418845
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99060668
124* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98790485
125P68_20966046_ChIP-Seq_HELA_Human0.98366230
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97908740
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97568367
128* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96602742
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94086047
130* MAF_26560356_Chip-Seq_TH2_Human0.93611336
131MYB_26560356_Chip-Seq_TH1_Human0.92820700
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92138904
133MYB_26560356_Chip-Seq_TH2_Human0.91878731
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91612622
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89040346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog2.99665502
2MP0010352_gastrointestinal_tract_polyps2.94893370
3MP0005076_abnormal_cell_differentiation2.80135893
4MP0003705_abnormal_hypodermis_morpholog2.77624232
5MP0003111_abnormal_nucleus_morphology2.63285320
6MP0010094_abnormal_chromosome_stability2.58081875
7MP0008057_abnormal_DNA_replication2.57340745
8MP0004264_abnormal_extraembryonic_tissu2.54434883
9MP0005451_abnormal_body_composition2.45564705
10MP0003693_abnormal_embryo_hatching2.45101272
11MP0000566_synostosis2.43803307
12MP0010030_abnormal_orbit_morphology2.43668462
13MP0003077_abnormal_cell_cycle2.42545361
14MP0003123_paternal_imprinting2.37249993
15MP0005409_darkened_coat_color2.32861980
16MP0001730_embryonic_growth_arrest2.06785786
17MP0002249_abnormal_larynx_morphology2.06061074
18MP0009053_abnormal_anal_canal2.04031268
19MP0000350_abnormal_cell_proliferation1.98565345
20MP0004197_abnormal_fetal_growth/weight/1.97930994
21MP0008007_abnormal_cellular_replicative1.94520600
22MP0000678_abnormal_parathyroid_gland1.89250182
23MP0002009_preneoplasia1.88672417
24MP0002084_abnormal_developmental_patter1.86580645
25MP0009278_abnormal_bone_marrow1.78367111
26MP0000537_abnormal_urethra_morphology1.76631899
27MP0002132_abnormal_respiratory_system1.76593725
28MP0001697_abnormal_embryo_size1.76288538
29MP0002085_abnormal_embryonic_tissue1.73373250
30MP0003315_abnormal_perineum_morphology1.72375232
31MP0003567_abnormal_fetal_cardiomyocyte1.71760625
32MP0008932_abnormal_embryonic_tissue1.70001656
33MP0005380_embryogenesis_phenotype1.68153232
34MP0001672_abnormal_embryogenesis/_devel1.68153232
35MP0002089_abnormal_postnatal_growth/wei1.67682568
36MP0003763_abnormal_thymus_physiology1.66920579
37MP0002086_abnormal_extraembryonic_tissu1.61677467
38MP0002877_abnormal_melanocyte_morpholog1.61036677
39MP0003984_embryonic_growth_retardation1.60919056
40MP0002796_impaired_skin_barrier1.60607884
41MP0002088_abnormal_embryonic_growth/wei1.59962242
42MP0003566_abnormal_cell_adhesion1.58667575
43MP0004381_abnormal_hair_follicle1.52019964
44MP0004808_abnormal_hematopoietic_stem1.50516727
45MP0000733_abnormal_muscle_development1.49638229
46MP0002653_abnormal_ependyma_morphology1.48636943
47MP0002080_prenatal_lethality1.47843039
48MP0010307_abnormal_tumor_latency1.47523568
49MP0004858_abnormal_nervous_system1.47159410
50MP0002396_abnormal_hematopoietic_system1.41571467
51MP0001849_ear_inflammation1.40591325
52MP0003119_abnormal_digestive_system1.38873268
53MP0001346_abnormal_lacrimal_gland1.37993493
54MP0005623_abnormal_meninges_morphology1.37896231
55MP0003890_abnormal_embryonic-extraembry1.36950559
56MP0000490_abnormal_crypts_of1.36619082
57MP0003091_abnormal_cell_migration1.31005447
58MP0003300_gastrointestinal_ulcer1.30778724
59MP0000428_abnormal_craniofacial_morphol1.29612561
60MP0003283_abnormal_digestive_organ1.27134284
61MP0001293_anophthalmia1.27077643
62MP0006054_spinal_hemorrhage1.23835142
63MP0008058_abnormal_DNA_repair1.18385066
64MP0004185_abnormal_adipocyte_glucose1.16493847
65MP0009780_abnormal_chondrocyte_physiolo1.15764522
66MP0000462_abnormal_digestive_system1.15587555
67MP0003303_peritoneal_inflammation1.15476185
68MP0009672_abnormal_birth_weight1.14836871
69MP0003115_abnormal_respiratory_system1.14449465
70MP0001348_abnormal_lacrimal_gland1.14315823
71MP0003121_genomic_imprinting1.14300449
72MP0005666_abnormal_adipose_tissue1.13007655
73MP0009703_decreased_birth_body1.12393593
74MP0005023_abnormal_wound_healing1.12099977
75MP0003942_abnormal_urinary_system1.11041362
76MP0010234_abnormal_vibrissa_follicle1.10008358
77MP0001915_intracranial_hemorrhage1.09335103
78MP0001545_abnormal_hematopoietic_system1.09250712
79MP0005397_hematopoietic_system_phenotyp1.09250712
80MP0002925_abnormal_cardiovascular_devel1.07509046
81MP0004233_abnormal_muscle_weight1.07489333
82MP0008877_abnormal_DNA_methylation1.06579452
83MP0005058_abnormal_lysosome_morphology1.06023436
84MP0005248_abnormal_Harderian_gland1.04950207
85MP0000313_abnormal_cell_death1.03663319
86MP0002019_abnormal_tumor_incidence1.03598069
87MP0000681_abnormal_thyroid_gland1.02433097
88MP0000703_abnormal_thymus_morphology1.02259833
89MP0005621_abnormal_cell_physiology1.01877948
90MP0003941_abnormal_skin_development1.01128761
91MP0003935_abnormal_craniofacial_develop0.98858729
92MP0002282_abnormal_trachea_morphology0.98447273
93MP0002697_abnormal_eye_size0.98316223
94MP0003385_abnormal_body_wall0.97389587
95MP0002166_altered_tumor_susceptibility0.94806029
96MP0002092_abnormal_eye_morphology0.91255126
97MP0002111_abnormal_tail_morphology0.91142385
98MP0006138_congestive_heart_failure0.89523743
99MP0000432_abnormal_head_morphology0.89097393
100MP0000858_altered_metastatic_potential0.87897347
101MP0008438_abnormal_cutaneous_collagen0.86998212
102MP0001270_distended_abdomen0.86795026
103MP0004087_abnormal_muscle_fiber0.86567070
104MP0008004_abnormal_stomach_pH0.85637795
105MP0003938_abnormal_ear_development0.85342696
106MP0002932_abnormal_joint_morphology0.84800234
107MP0000049_abnormal_middle_ear0.84080000
108MP0006072_abnormal_retinal_apoptosis0.84046157
109MP0003937_abnormal_limbs/digits/tail_de0.83623915
110MP0005375_adipose_tissue_phenotype0.83534643
111MP0000627_abnormal_mammary_gland0.83486950
112MP0009333_abnormal_splenocyte_physiolog0.83483105
113MP0003786_premature_aging0.83027712
114MP0001286_abnormal_eye_development0.82028791
115MP0004782_abnormal_surfactant_physiolog0.81622964
116MP0004272_abnormal_basement_membrane0.81039002
117MP0004133_heterotaxia0.80886406
118MP0002234_abnormal_pharynx_morphology0.79657671
119MP0002108_abnormal_muscle_morphology0.79647918
120MP0009931_abnormal_skin_appearance0.79305671
121MP0003453_abnormal_keratinocyte_physiol0.78516513
122MP0000516_abnormal_urinary_system0.78099185
123MP0005367_renal/urinary_system_phenotyp0.78099185
124MP0003755_abnormal_palate_morphology0.77978664
125MP0002210_abnormal_sex_determination0.77371837
126MP0010630_abnormal_cardiac_muscle0.77300430
127MP0000762_abnormal_tongue_morphology0.76616878
128MP0005501_abnormal_skin_physiology0.76396378
129MP0000266_abnormal_heart_morphology0.76391290
130MP0002098_abnormal_vibrissa_morphology0.76235225
131MP0003448_altered_tumor_morphology0.76019405
132MP0008789_abnormal_olfactory_epithelium0.75813465
133MP0002114_abnormal_axial_skeleton0.75051920
134MP0000477_abnormal_intestine_morphology0.74643708
135MP0002127_abnormal_cardiovascular_syste0.74498214
136MP0008260_abnormal_autophagy0.73317459
137MP0001784_abnormal_fluid_regulation0.73164224
138MP0001145_abnormal_male_reproductive0.72609337
139MP0000534_abnormal_ureter_morphology0.71803590
140MP0002116_abnormal_craniofacial_bone0.69943310

Predicted human phenotypes

RankGene SetZ-score
1Asymmetry of the thorax (HP:0001555)3.45433407
2Reticulocytopenia (HP:0001896)3.15190093
3Selective tooth agenesis (HP:0001592)3.07082275
4Protrusio acetabuli (HP:0003179)2.96179732
5Increased nuchal translucency (HP:0010880)2.95214581
6Colon cancer (HP:0003003)2.92669695
7Abnormality of the columella (HP:0009929)2.88112642
8Renal duplication (HP:0000075)2.86567790
9Ependymoma (HP:0002888)2.85957754
10Hyperacusis (HP:0010780)2.84937031
11Germ cell neoplasia (HP:0100728)2.76256192
12Rectal prolapse (HP:0002035)2.73427382
13Abnormality of cells of the erythroid lineage (HP:0012130)2.71861264
14Proximal placement of thumb (HP:0009623)2.71356862
15Obstructive sleep apnea (HP:0002870)2.69603085
16Deviation of the thumb (HP:0009603)2.68715874
17Syringomyelia (HP:0003396)2.66879374
18Spinal cord lesions (HP:0100561)2.66879374
19Missing ribs (HP:0000921)2.66598870
20Short 4th metacarpal (HP:0010044)2.65842150
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.65842150
22Partial duplication of thumb phalanx (HP:0009944)2.51959061
23Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.50978385
24Volvulus (HP:0002580)2.50808896
25High anterior hairline (HP:0009890)2.48760510
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.48599924
27Pseudobulbar signs (HP:0002200)2.44914966
28Shallow orbits (HP:0000586)2.38120357
29Deep palmar crease (HP:0006191)2.37794781
30Abnormal number of erythroid precursors (HP:0012131)2.36499319
31Ankle contracture (HP:0006466)2.36299508
32Partial duplication of the phalanx of hand (HP:0009999)2.35179127
33Basal cell carcinoma (HP:0002671)2.31573600
34Abnormality of the thoracic spine (HP:0100711)2.31222190
35Abnormality of the distal phalanx of the thumb (HP:0009617)2.29206040
36Atresia of the external auditory canal (HP:0000413)2.27307732
37Posterior subcapsular cataract (HP:0007787)2.27273673
38Broad face (HP:0000283)2.21241807
39Thoracic kyphosis (HP:0002942)2.21158432
40Trismus (HP:0000211)2.20448735
41Increased density of long bones (HP:0006392)2.20176476
42Flat acetabular roof (HP:0003180)2.17042818
43Genu recurvatum (HP:0002816)2.16835111
44Abnormality of the astrocytes (HP:0100707)2.16389413
45Astrocytoma (HP:0009592)2.16389413
46Broad palm (HP:0001169)2.15829356
47Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.12653087
48Long palpebral fissure (HP:0000637)2.12375810
49Broad thumb (HP:0011304)2.12224970
50Abnormality of the 4th metacarpal (HP:0010012)2.12040007
51Medulloblastoma (HP:0002885)2.11813649
52Cerebral aneurysm (HP:0004944)2.10992965
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09682263
54Overlapping toe (HP:0001845)2.09604939
55Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08397322
56Disproportionate tall stature (HP:0001519)2.07298408
57High pitched voice (HP:0001620)2.05989152
58Rib fusion (HP:0000902)2.05750099
59Aplasia involving bones of the upper limbs (HP:0009823)2.04879560
60Aplasia of the phalanges of the hand (HP:0009802)2.04879560
61Aplasia involving bones of the extremities (HP:0009825)2.04879560
62Abnormality of the fingertips (HP:0001211)2.04014174
63Abnormality of the lumbar spine (HP:0100712)2.03870730
64Thickened helices (HP:0000391)2.03540150
65Gastrointestinal carcinoma (HP:0002672)2.03437212
66Malignant gastrointestinal tract tumors (HP:0006749)2.03437212
67Rhabdomyosarcoma (HP:0002859)2.03111624
68Dysmetric saccades (HP:0000641)2.02986669
69Facial hemangioma (HP:0000329)2.02105836
70Abnormality of the salivary glands (HP:0010286)2.01661794
71Skin tags (HP:0010609)2.01334908
72Abnormal number of incisors (HP:0011064)2.00563694
73Abnormality of oral frenula (HP:0000190)1.99055484
74Neoplasm of striated muscle (HP:0009728)1.98325158
75Deviation of the hallux (HP:0010051)1.97770286
76Abnormality of the calcaneus (HP:0008364)1.97208762
77Enlarged penis (HP:0000040)1.97045984
78Ulnar bowing (HP:0003031)1.96638546
79Thin ribs (HP:0000883)1.96254511
80Abdominal situs inversus (HP:0003363)1.95962408
81Abnormality of abdominal situs (HP:0011620)1.95962408
82Hallux valgus (HP:0001822)1.93709971
83Long eyelashes (HP:0000527)1.92783086
84Neoplasm of the oral cavity (HP:0100649)1.91728203
85Aortic aneurysm (HP:0004942)1.91335244
86Neonatal short-limb short stature (HP:0008921)1.90297191
87Pendular nystagmus (HP:0012043)1.89583924
88Bladder diverticulum (HP:0000015)1.89408028
89Supernumerary ribs (HP:0005815)1.89023939
90Broad distal phalanx of finger (HP:0009836)1.87454905
91Renovascular hypertension (HP:0100817)1.87392934
92Bowel diverticulosis (HP:0005222)1.87388689
93Overriding aorta (HP:0002623)1.86240077
94Macrocytic anemia (HP:0001972)1.86225230
95Short humerus (HP:0005792)1.84753473
96Macroorchidism (HP:0000053)1.84696826
97Aplasia/hypoplasia of the humerus (HP:0006507)1.84063965
98Abnormality of the diencephalon (HP:0010662)1.83240513
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.82725309
100Vertebral hypoplasia (HP:0008417)1.82725309
101Self-mutilation (HP:0000742)1.82010081
102Patellar dislocation (HP:0002999)1.81942830
103Insomnia (HP:0100785)1.81524867
104Elfin facies (HP:0004428)1.81292799
105Preauricular skin tag (HP:0000384)1.81180028
106Adenoma sebaceum (HP:0009720)1.80477696
107Angiofibromas (HP:0010615)1.80477696
108Resting tremor (HP:0002322)1.80465993
109Increased variability in muscle fiber diameter (HP:0003557)1.78919703
110Intestinal polyp (HP:0005266)1.77571388
111Hypercortisolism (HP:0001578)1.77103917
112Broad toe (HP:0001837)1.77065285
113Absent thumb (HP:0009777)1.77053058
114Abnormality of the frontal sinuses (HP:0002687)1.76606048
115Trigonocephaly (HP:0000243)1.76436833
116Nasolacrimal duct obstruction (HP:0000579)1.75963498
117Turricephaly (HP:0000262)1.75939289
118Short phalanx of the thumb (HP:0009660)1.75743884
119Back pain (HP:0003418)1.75353078
120Heterotopia (HP:0002282)1.75351805
121Pallor (HP:0000980)1.74660784
122Arnold-Chiari malformation (HP:0002308)1.74159880
123Broad phalanges of the hand (HP:0009768)1.73638601
124Abnormality of the phalanges of the hallux (HP:0010057)1.73434730
125Abnormal hemoglobin (HP:0011902)1.73422705
126Supernumerary bones of the axial skeleton (HP:0009144)1.72043833
127Duplication of thumb phalanx (HP:0009942)1.70504362
128Flared metaphyses (HP:0003015)1.70051979
129Patellar aplasia (HP:0006443)1.69102343
130Biliary tract neoplasm (HP:0100574)1.67143202
131Intestinal polyposis (HP:0200008)1.66948561
132Abnormality of the incisor (HP:0000676)1.66462650
133Metaphyseal cupping (HP:0003021)1.66421219
13411 pairs of ribs (HP:0000878)1.66339751
135Bicuspid aortic valve (HP:0001647)1.65672068
136Urethral obstruction (HP:0000796)1.65038320
137Sparse lateral eyebrow (HP:0005338)1.64494339
138Short 5th finger (HP:0009237)1.64203589
139Multiple enchondromatosis (HP:0005701)1.64091620
140Septate vagina (HP:0001153)1.63332790
141Fibroma (HP:0010614)1.62981068
142Cutis marmorata (HP:0000965)1.62361917
143Testicular neoplasm (HP:0010788)1.62329915
144Broad hallux (HP:0010055)1.62220288
145Dislocated radial head (HP:0003083)1.62218592
146Short 1st metacarpal (HP:0010034)1.62010386
147Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62010386
148Fibrous tissue neoplasm (HP:0012316)1.60952642
149Aneurysm (HP:0002617)1.59795259
150Vertebral fusion (HP:0002948)1.59784465
151Aplasia/Hypoplasia of the patella (HP:0006498)1.59637797
152Abnormality of incisor morphology (HP:0011063)1.59592501
153Ankyloglossia (HP:0010296)1.58824595
154Abnormality of the parietal bone (HP:0002696)1.58567464
155Mitral valve prolapse (HP:0001634)1.58381335
156Uterine leiomyosarcoma (HP:0002891)1.57864597
157Leiomyosarcoma (HP:0100243)1.57864597
158Transitional cell carcinoma of the bladder (HP:0006740)1.57668018
159Bowel incontinence (HP:0002607)1.57087327
160Abnormal tarsal ossification (HP:0008369)1.55563907
161Abnormal foot bone ossification (HP:0010675)1.55503252
162Spinal rigidity (HP:0003306)1.54847913
163Abnormality of the aortic arch (HP:0012303)1.54724553
164Abnormality of the radial head (HP:0003995)1.54642667
165Acute lymphatic leukemia (HP:0006721)1.54432968
166Segmental peripheral demyelination/remyelination (HP:0003481)1.54287692
167Abnormality of skeletal muscle fiber size (HP:0012084)1.53127778
168Vertebral arch anomaly (HP:0008438)1.52339098
169Multiple lipomas (HP:0001012)1.50059847
170Abnormality of the lacrimal duct (HP:0011481)1.49164725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.92955348
2MAP3K103.51546576
3SMG13.50961195
4EEF2K3.34753467
5PKN23.21240618
6TRIB33.18103555
7CDC73.13094105
8PRPF4B2.93931860
9NEK22.36436823
10SIK12.20822463
11ICK2.14850558
12WEE12.08340782
13PASK1.86610475
14MAP3K131.77635603
15FGFR41.77202830
16BRD41.74804460
17CDK61.70688931
18CDK71.65174066
19ALK1.65160018
20PTK61.61922139
21STK101.59644706
22CDK41.59429045
23PAK41.59135508
24NME21.57225060
25LRRK21.56799170
26RPS6KA41.55887660
27RPS6KB21.54866576
28TTK1.50858844
29NEK11.42575387
30TGFBR11.42307151
31MARK31.41818323
32FGFR31.34282742
33MKNK11.30296057
34LATS11.29599317
35PDGFRA1.28947746
36BMX1.28888022
37SCYL21.27764412
38KSR21.27737314
39RIPK11.24915332
40FLT31.24192845
41MAP3K81.19988963
42MTOR1.18386423
43BUB11.18324962
44TSSK61.17363094
45MAP3K91.15399243
46FGFR21.13587566
47TESK21.10747503
48STK31.10550554
49IRAK31.04315484
50PAK21.03171602
51PRKD31.01965855
52CDC42BPA0.99020932
53MKNK20.98746624
54ATR0.98194151
55CHEK10.97602143
56MAP2K30.96279312
57PLK10.95935064
58EPHA20.94738210
59ERN10.93308126
60MAP3K10.92934867
61TTN0.91452489
62BRSK20.89811645
63AURKB0.89506537
64IRAK20.89164284
65PIM10.87260793
66TESK10.85844617
67MAP4K10.85171591
68RET0.84977231
69CDK190.84431210
70LATS20.84072609
71CDK90.83664102
72MARK20.82219205
73DYRK30.81600317
74DDR20.79491830
75CDK20.78919836
76TAOK20.78618018
77DYRK1B0.77905286
78CDK30.77821698
79SIK30.75189706
80FGFR10.74764238
81MOS0.72412041
82ILK0.71873318
83ATM0.71708057
84HIPK20.70244716
85STK40.70027706
86SGK30.68719828
87TYRO30.68014370
88SIK20.67710592
89PDPK10.67168351
90EPHB20.67098127
91TAOK10.66447764
92CAMK1G0.65516440
93PRKD20.65398773
94CLK10.65166643
95DMPK0.64314796
96ARAF0.63772391
97MELK0.61663970
98MAPK110.61490147
99GRK60.61200668
100ACVR1B0.60514298
101EIF2AK10.60222441
102CHEK20.59261125
103EPHB10.59178776
104MAP3K110.56811124
105RPS6KA20.56387524
106RPS6KB10.55207546
107NLK0.54560005
108PTK20.53637192
109BRAF0.53618238
110PDGFRB0.50442854
111MAP3K70.50253400
112PAK10.50192721
113RPS6KL10.49375370
114RPS6KC10.49375370
115BTK0.48853068
116RIPK40.46166062
117CDK80.45845372
118CDK10.45786928
119PLK30.45783124
120AURKA0.44985201
121AKT20.44912678
122MAPK120.44531295
123CSK0.43934708
124RPS6KA10.43350900
125CSNK2A20.43308149
126CAMK1D0.42367969
127CSNK1E0.41727596
128MAPK10.41174017
129PIM20.40885129
130PRKDC0.40779893
131SGK2230.40596434
132SGK4940.40596434
133PDK10.38544768
134STK380.38423234
135TAF10.38215709
136MAP3K20.36937262
137ZAP700.36212742
138MAP2K20.35692431
139MAPK140.35448292
140PRKG20.35321141
141MAPKAPK20.34734224
142CHUK0.34465222
143MAP3K30.34033726
144CSNK1D0.33757993

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59733754
2Ribosome_Homo sapiens_hsa030103.26795063
3Spliceosome_Homo sapiens_hsa030403.14200853
4RNA transport_Homo sapiens_hsa030132.94091190
5Mismatch repair_Homo sapiens_hsa034302.88721116
6mRNA surveillance pathway_Homo sapiens_hsa030152.49819667
7Cell cycle_Homo sapiens_hsa041102.44365431
8One carbon pool by folate_Homo sapiens_hsa006702.24860248
9Base excision repair_Homo sapiens_hsa034102.19085353
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17548232
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86282641
12Nucleotide excision repair_Homo sapiens_hsa034201.80476410
13Homologous recombination_Homo sapiens_hsa034401.69496440
14Chronic myeloid leukemia_Homo sapiens_hsa052201.64655366
15Adherens junction_Homo sapiens_hsa045201.55787023
16Thyroid cancer_Homo sapiens_hsa052161.55274483
17Basal cell carcinoma_Homo sapiens_hsa052171.48257707
18p53 signaling pathway_Homo sapiens_hsa041151.48144697
19MicroRNAs in cancer_Homo sapiens_hsa052061.46980855
20RNA degradation_Homo sapiens_hsa030181.45060173
21Notch signaling pathway_Homo sapiens_hsa043301.44274720
22Hippo signaling pathway_Homo sapiens_hsa043901.43826197
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41882674
24Small cell lung cancer_Homo sapiens_hsa052221.41257254
25Antigen processing and presentation_Homo sapiens_hsa046121.38511964
26HTLV-I infection_Homo sapiens_hsa051661.31121404
27ErbB signaling pathway_Homo sapiens_hsa040121.31086298
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25093656
29Bladder cancer_Homo sapiens_hsa052191.24535712
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22526054
31Lysine degradation_Homo sapiens_hsa003101.20912963
32Proteoglycans in cancer_Homo sapiens_hsa052051.20687478
33Acute myeloid leukemia_Homo sapiens_hsa052211.19678838
34Herpes simplex infection_Homo sapiens_hsa051681.18418787
35TGF-beta signaling pathway_Homo sapiens_hsa043501.17602021
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17054629
37Pentose phosphate pathway_Homo sapiens_hsa000301.13845939
38Choline metabolism in cancer_Homo sapiens_hsa052311.12449647
39mTOR signaling pathway_Homo sapiens_hsa041501.11038200
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09438792
41Viral carcinogenesis_Homo sapiens_hsa052031.08820957
42Hedgehog signaling pathway_Homo sapiens_hsa043401.08433396
43Colorectal cancer_Homo sapiens_hsa052101.08215667
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07140538
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.05368555
46Epstein-Barr virus infection_Homo sapiens_hsa051691.04644808
47Oocyte meiosis_Homo sapiens_hsa041141.04628816
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03534476
49Prostate cancer_Homo sapiens_hsa052151.03323697
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02481723
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01557594
52Fanconi anemia pathway_Homo sapiens_hsa034601.00892981
53Long-term potentiation_Homo sapiens_hsa047201.00269328
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99824287
55Non-homologous end-joining_Homo sapiens_hsa034500.97783997
56Melanogenesis_Homo sapiens_hsa049160.96072088
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93874000
58Viral myocarditis_Homo sapiens_hsa054160.93646335
59Endometrial cancer_Homo sapiens_hsa052130.93534467
60Basal transcription factors_Homo sapiens_hsa030220.92909862
61Focal adhesion_Homo sapiens_hsa045100.92238291
62Non-small cell lung cancer_Homo sapiens_hsa052230.90503373
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.89418988
64Prion diseases_Homo sapiens_hsa050200.89308988
65Other glycan degradation_Homo sapiens_hsa005110.87422940
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.87147662
67Fructose and mannose metabolism_Homo sapiens_hsa000510.86158359
68Hepatitis C_Homo sapiens_hsa051600.85735707
69Wnt signaling pathway_Homo sapiens_hsa043100.85326826
70Gap junction_Homo sapiens_hsa045400.84870019
71Pathways in cancer_Homo sapiens_hsa052000.84633706
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84181444
73GnRH signaling pathway_Homo sapiens_hsa049120.80753257
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.79898486
75Inositol phosphate metabolism_Homo sapiens_hsa005620.79895185
76Pyrimidine metabolism_Homo sapiens_hsa002400.79804845
77Shigellosis_Homo sapiens_hsa051310.79752976
78Hepatitis B_Homo sapiens_hsa051610.79410328
79Glucagon signaling pathway_Homo sapiens_hsa049220.78417714
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78072409
81RNA polymerase_Homo sapiens_hsa030200.77675475
82HIF-1 signaling pathway_Homo sapiens_hsa040660.77631858
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75863520
84Pancreatic cancer_Homo sapiens_hsa052120.75777826
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73151309
86Tight junction_Homo sapiens_hsa045300.72968900
87VEGF signaling pathway_Homo sapiens_hsa043700.71914103
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.70985653
89B cell receptor signaling pathway_Homo sapiens_hsa046620.69558331
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69513120
91Renal cell carcinoma_Homo sapiens_hsa052110.69172066
92ECM-receptor interaction_Homo sapiens_hsa045120.68670878
93Legionellosis_Homo sapiens_hsa051340.67358346
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.66803698
95Biosynthesis of amino acids_Homo sapiens_hsa012300.66159078
96Phototransduction_Homo sapiens_hsa047440.66098444
97Apoptosis_Homo sapiens_hsa042100.65366294
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64793118
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64151306
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63007631
101Toxoplasmosis_Homo sapiens_hsa051450.59641541
102AMPK signaling pathway_Homo sapiens_hsa041520.58153082
103Glioma_Homo sapiens_hsa052140.58032191
104Influenza A_Homo sapiens_hsa051640.57362813
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56925724
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56468494
107Dorso-ventral axis formation_Homo sapiens_hsa043200.56259065
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55676914
109Melanoma_Homo sapiens_hsa052180.53914840
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52997048
111MAPK signaling pathway_Homo sapiens_hsa040100.52360656
112Measles_Homo sapiens_hsa051620.50960085
113Thyroid hormone synthesis_Homo sapiens_hsa049180.50957184
114Rap1 signaling pathway_Homo sapiens_hsa040150.49755945
115FoxO signaling pathway_Homo sapiens_hsa040680.49350614
116Type II diabetes mellitus_Homo sapiens_hsa049300.48605414
117Platelet activation_Homo sapiens_hsa046110.47993341
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47450432
119T cell receptor signaling pathway_Homo sapiens_hsa046600.46603728
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46308804
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45898485
122Amoebiasis_Homo sapiens_hsa051460.43810042
123Leishmaniasis_Homo sapiens_hsa051400.42834018
124Selenocompound metabolism_Homo sapiens_hsa004500.42561930
125Estrogen signaling pathway_Homo sapiens_hsa049150.41801469
126Insulin resistance_Homo sapiens_hsa049310.39390190
127Prolactin signaling pathway_Homo sapiens_hsa049170.38707465
128Insulin signaling pathway_Homo sapiens_hsa049100.38418926
129Primary immunodeficiency_Homo sapiens_hsa053400.37218884
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.35195870

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