PBK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.00235868
2mitotic chromosome condensation (GO:0007076)5.68963520
3DNA strand elongation involved in DNA replication (GO:0006271)5.62368631
4mitotic metaphase plate congression (GO:0007080)5.57456444
5kinetochore organization (GO:0051383)5.49966873
6attachment of spindle microtubules to kinetochore (GO:0008608)5.48470292
7CENP-A containing nucleosome assembly (GO:0034080)5.48116462
8telomere maintenance via semi-conservative replication (GO:0032201)5.46726981
9protein localization to chromosome, centromeric region (GO:0071459)5.40201766
10DNA unwinding involved in DNA replication (GO:0006268)5.36133728
11DNA strand elongation (GO:0022616)5.32740527
12chromatin remodeling at centromere (GO:0031055)5.31246448
13mitotic sister chromatid segregation (GO:0000070)5.17088714
14mitotic recombination (GO:0006312)5.07361047
15DNA replication initiation (GO:0006270)5.01946691
16telomere maintenance via recombination (GO:0000722)4.99989707
17sister chromatid segregation (GO:0000819)4.99276925
18metaphase plate congression (GO:0051310)4.92707769
19DNA replication-independent nucleosome organization (GO:0034724)4.90613207
20DNA replication-independent nucleosome assembly (GO:0006336)4.90613207
21DNA replication checkpoint (GO:0000076)4.88182484
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.70162369
23kinetochore assembly (GO:0051382)4.62825755
24regulation of spindle organization (GO:0090224)4.59395846
25histone exchange (GO:0043486)4.58570521
26establishment of chromosome localization (GO:0051303)4.51933221
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.48268923
28meiotic chromosome segregation (GO:0045132)4.46055145
29telomere maintenance via telomere lengthening (GO:0010833)4.28951779
30nucleotide-excision repair, DNA gap filling (GO:0006297)4.28585280
31DNA replication-dependent nucleosome assembly (GO:0006335)4.23818963
32DNA replication-dependent nucleosome organization (GO:0034723)4.23818963
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22340183
34mitotic nuclear envelope disassembly (GO:0007077)4.05142122
35chromosome segregation (GO:0007059)4.01590140
36DNA topological change (GO:0006265)3.96699414
37spindle checkpoint (GO:0031577)3.94720267
38chromosome condensation (GO:0030261)3.92468732
39establishment of integrated proviral latency (GO:0075713)3.92089115
40protein localization to chromosome (GO:0034502)3.90183857
41regulation of chromosome segregation (GO:0051983)3.88268516
42deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.82501616
43nuclear envelope disassembly (GO:0051081)3.75007838
44membrane disassembly (GO:0030397)3.75007838
45nucleobase biosynthetic process (GO:0046112)3.74553495
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.72383713
47protein K6-linked ubiquitination (GO:0085020)3.72308196
48purine nucleobase biosynthetic process (GO:0009113)3.70440518
49nuclear pore organization (GO:0006999)3.68581286
50regulation of mitotic spindle organization (GO:0060236)3.67588239
51chromatin assembly or disassembly (GO:0006333)3.67323145
52negative regulation of chromosome segregation (GO:0051985)3.66133693
53spindle assembly checkpoint (GO:0071173)3.65840894
54deoxyribonucleotide biosynthetic process (GO:0009263)3.65819555
55negative regulation of mitotic sister chromatid separation (GO:2000816)3.65745374
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.65745374
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.65745374
58negative regulation of sister chromatid segregation (GO:0033046)3.65745374
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.60411772
60pore complex assembly (GO:0046931)3.57614660
61DNA packaging (GO:0006323)3.55857355
62histone-serine phosphorylation (GO:0035404)3.55636274
63negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55197604
64mitotic sister chromatid cohesion (GO:0007064)3.55106690
65ATP-dependent chromatin remodeling (GO:0043044)3.54965810
66positive regulation of chromosome segregation (GO:0051984)3.54854991
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.52382441
68mitotic spindle assembly checkpoint (GO:0007094)3.52010089
69ventricular cardiac muscle cell development (GO:0055015)3.50328122
70regulation of centrosome cycle (GO:0046605)3.48551915
71regulation of sister chromatid cohesion (GO:0007063)3.48406536
72DNA ligation (GO:0006266)3.45400955
73mitotic spindle checkpoint (GO:0071174)3.44914867
74mitotic cell cycle (GO:0000278)3.43094236
75regulation of sister chromatid segregation (GO:0033045)3.40069149
76regulation of mitotic sister chromatid separation (GO:0010965)3.40069149
77regulation of mitotic sister chromatid segregation (GO:0033047)3.40069149
78nuclear pore complex assembly (GO:0051292)3.39682666
79mitotic spindle organization (GO:0007052)3.38519829
80translesion synthesis (GO:0019985)3.36776292
81non-recombinational repair (GO:0000726)3.36710838
82double-strand break repair via nonhomologous end joining (GO:0006303)3.36710838
83telomere maintenance (GO:0000723)3.31081842
84negative regulation of mitosis (GO:0045839)3.30099716
85telomere organization (GO:0032200)3.29502858
86spindle assembly involved in mitosis (GO:0090307)3.25964074
87mitotic cytokinesis (GO:0000281)3.25947665
88DNA conformation change (GO:0071103)3.25649349
89microtubule depolymerization (GO:0007019)3.24217647
90regulation of DNA endoreduplication (GO:0032875)3.24078296
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23169184
92anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20180181
93mismatch repair (GO:0006298)3.20104286
94DNA geometric change (GO:0032392)3.19855010
95postreplication repair (GO:0006301)3.19623617
96DNA duplex unwinding (GO:0032508)3.19397096
97DNA synthesis involved in DNA repair (GO:0000731)3.18266576
98cell cycle G1/S phase transition (GO:0044843)3.18016138
99G1/S transition of mitotic cell cycle (GO:0000082)3.18016138
100nucleobase-containing small molecule interconversion (GO:0015949)3.15960635
101DNA deamination (GO:0045006)3.13752652
102proteasome assembly (GO:0043248)3.12925520
103ribosomal small subunit assembly (GO:0000028)3.12685713
104formation of translation preinitiation complex (GO:0001731)3.12603661
105transcription-coupled nucleotide-excision repair (GO:0006283)3.12098034
106maturation of SSU-rRNA (GO:0030490)3.10290556
107nuclear envelope organization (GO:0006998)3.10133670
108microtubule polymerization or depolymerization (GO:0031109)3.09818193
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08282817
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08282817
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.08282817
112regulation of nuclear cell cycle DNA replication (GO:0033262)3.07582021
113regulation of centriole replication (GO:0046599)3.06056661
114resolution of meiotic recombination intermediates (GO:0000712)3.04739583
115IMP biosynthetic process (GO:0006188)3.04597806
116establishment of mitotic spindle localization (GO:0040001)3.04028419
117* mitotic nuclear division (GO:0007067)3.03614038
118chromosome organization (GO:0051276)3.02873286
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02472060
120spindle organization (GO:0007051)3.01970460
121regulation of centrosome duplication (GO:0010824)3.00171277
122synapsis (GO:0007129)2.98811179
123mitotic G2/M transition checkpoint (GO:0044818)2.97045652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.53550448
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.74851939
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.26267057
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.73067157
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.42035902
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23821858
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.02176651
8* AR_21909140_ChIP-Seq_LNCAP_Human3.00433455
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.72127271
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66670795
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58155607
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54433561
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53627998
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.49792148
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.43394021
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.40658442
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.38626815
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27534159
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27252064
20XRN2_22483619_ChIP-Seq_HELA_Human2.20550023
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12203050
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11052007
23VDR_23849224_ChIP-Seq_CD4+_Human2.05107847
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04951336
25E2F7_22180533_ChIP-Seq_HELA_Human10.9099722
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98991375
27* DCP1A_22483619_ChIP-Seq_HELA_Human1.93118412
28FOXP3_21729870_ChIP-Seq_TREG_Human1.87767099
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.87139732
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.87023869
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81238256
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80446021
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78321142
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76722094
35TTF2_22483619_ChIP-Seq_HELA_Human1.75909796
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75606142
37GABP_19822575_ChIP-Seq_HepG2_Human1.70397107
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60974131
39ELK1_19687146_ChIP-ChIP_HELA_Human1.58546135
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57609142
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57342043
42CIITA_25753668_ChIP-Seq_RAJI_Human1.57118025
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56911126
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51656984
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49776160
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49260103
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46716890
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42774555
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42584617
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40459810
51KDM5A_27292631_Chip-Seq_BREAST_Human1.37336096
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35575688
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34870087
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32919505
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27596884
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.26697825
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25511771
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.20910399
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17325906
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14635960
61MYC_22102868_ChIP-Seq_BL_Human1.14096544
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.12435899
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11775989
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11338750
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10148501
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08269982
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07518722
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06664621
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98818380
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98410181
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97469792
72MYC_18940864_ChIP-ChIP_HL60_Human0.97339451
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96074339
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93084498
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92101708
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88153700
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87495593
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86431346
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86246595
80* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86142157
81TFEB_21752829_ChIP-Seq_HELA_Human0.86111852
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85264192
83ZNF263_19887448_ChIP-Seq_K562_Human0.83446956
84TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82989898
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82857629
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81053473
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79946515
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.77582623
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77193056
90NANOG_21062744_ChIP-ChIP_HESCs_Human0.77131543
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76133651
92VDR_21846776_ChIP-Seq_THP-1_Human0.75319875
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74947798
94CHD1_26751641_Chip-Seq_LNCaP_Human0.74831559
95* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74807858
96SPI1_23547873_ChIP-Seq_NB4_Human0.74116777
97EWS_26573619_Chip-Seq_HEK293_Human0.73617704
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73403348
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73369629
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72169685
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.71902539
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70074991
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67090208
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.66335298
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.64315620
106SALL1_21062744_ChIP-ChIP_HESCs_Human0.64283497
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.64246222
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.63170392
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.60842170
110GATA4_21415370_ChIP-Seq_HL-1_Mouse0.60522292
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.57943114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.99732345
2MP0010094_abnormal_chromosome_stability5.61413892
3MP0003111_abnormal_nucleus_morphology5.22132994
4MP0003077_abnormal_cell_cycle4.61591895
5MP0008057_abnormal_DNA_replication4.53096059
6MP0004957_abnormal_blastocyst_morpholog4.52874902
7MP0008058_abnormal_DNA_repair3.50773388
8MP0008007_abnormal_cellular_replicative3.24691597
9MP0008932_abnormal_embryonic_tissue2.77706832
10MP0008877_abnormal_DNA_methylation2.74249840
11MP0002396_abnormal_hematopoietic_system2.29696171
12MP0001730_embryonic_growth_arrest2.27568680
13MP0000350_abnormal_cell_proliferation2.23100780
14MP0003123_paternal_imprinting2.15184869
15MP0010307_abnormal_tumor_latency2.12553352
16MP0003786_premature_aging2.09990293
17MP0002877_abnormal_melanocyte_morpholog1.89006766
18MP0004808_abnormal_hematopoietic_stem1.76632215
19MP0001697_abnormal_embryo_size1.73966997
20MP0001672_abnormal_embryogenesis/_devel1.67811046
21MP0005380_embryogenesis_phenotype1.67811046
22MP0002210_abnormal_sex_determination1.61241970
23MP0000490_abnormal_crypts_of1.60648319
24MP0003718_maternal_effect1.56691657
25MP0002080_prenatal_lethality1.54937396
26MP0006054_spinal_hemorrhage1.51979547
27MP0000313_abnormal_cell_death1.49849408
28MP0003984_embryonic_growth_retardation1.47726205
29MP0003806_abnormal_nucleotide_metabolis1.45028235
30MP0002019_abnormal_tumor_incidence1.44565215
31MP0002088_abnormal_embryonic_growth/wei1.43499478
32MP0002085_abnormal_embryonic_tissue1.42127567
33MP0010352_gastrointestinal_tract_polyps1.39322678
34MP0001145_abnormal_male_reproductive1.39312273
35MP0005171_absent_coat_pigmentation1.37672281
36MP0001929_abnormal_gametogenesis1.37027339
37MP0001346_abnormal_lacrimal_gland1.35468874
38MP0003705_abnormal_hypodermis_morpholog1.32326294
39MP0006292_abnormal_olfactory_placode1.25603640
40MP0002086_abnormal_extraembryonic_tissu1.22824576
41MP0002697_abnormal_eye_size1.21383599
42MP0003950_abnormal_plasma_membrane1.21195616
43MP0000653_abnormal_sex_gland1.21168320
44MP0003567_abnormal_fetal_cardiomyocyte1.21099563
45MP0005397_hematopoietic_system_phenotyp1.20613872
46MP0001545_abnormal_hematopoietic_system1.20613872
47MP0003121_genomic_imprinting1.18205136
48MP0002084_abnormal_developmental_patter1.17356591
49MP0003315_abnormal_perineum_morphology1.16099881
50MP0004197_abnormal_fetal_growth/weight/1.15154203
51MP0005076_abnormal_cell_differentiation1.13173820
52MP0006035_abnormal_mitochondrial_morpho1.11752361
53MP0010030_abnormal_orbit_morphology1.06684995
54MP0003941_abnormal_skin_development1.04633407
55MP0000703_abnormal_thymus_morphology1.03263664
56MP0005623_abnormal_meninges_morphology1.00767402
57MP0009333_abnormal_splenocyte_physiolog0.99726747
58MP0001119_abnormal_female_reproductive0.99427779
59MP0000372_irregular_coat_pigmentation0.97687999
60MP0003136_yellow_coat_color0.95828126
61MP0003385_abnormal_body_wall0.94897647
62MP0003755_abnormal_palate_morphology0.93520901
63MP0001293_anophthalmia0.90411110
64MP0002398_abnormal_bone_marrow0.89015522
65MP0004233_abnormal_muscle_weight0.88824814
66MP0009053_abnormal_anal_canal0.88145214
67MP0003890_abnormal_embryonic-extraembry0.87711014
68MP0003763_abnormal_thymus_physiology0.87116485
69MP0009672_abnormal_birth_weight0.86798939
70MP0001529_abnormal_vocalization0.85856638
71MP0001727_abnormal_embryo_implantation0.85748054
72MP0002233_abnormal_nose_morphology0.84085168
73MP0000647_abnormal_sebaceous_gland0.82636957
74MP0002722_abnormal_immune_system0.82561107
75MP0002095_abnormal_skin_pigmentation0.82156579
76MP0002009_preneoplasia0.80520801
77MP0003937_abnormal_limbs/digits/tail_de0.80169524
78MP0003698_abnormal_male_reproductive0.79582243
79MP0002160_abnormal_reproductive_system0.79506404
80MP0009278_abnormal_bone_marrow0.79394440
81MP0000537_abnormal_urethra_morphology0.79238970
82MP0002132_abnormal_respiratory_system0.78040696
83MP0005248_abnormal_Harderian_gland0.77100465
84MP0003861_abnormal_nervous_system0.76021782
85MP0010234_abnormal_vibrissa_follicle0.74855391
86MP0005389_reproductive_system_phenotype0.74681843
87MP0000689_abnormal_spleen_morphology0.73718083
88MP0003935_abnormal_craniofacial_develop0.72913917
89MP0000383_abnormal_hair_follicle0.72487184
90MP0003942_abnormal_urinary_system0.71670603
91MP0002938_white_spotting0.71001968
92MP0008789_abnormal_olfactory_epithelium0.70665759
93MP0005395_other_phenotype0.70624935
94MP0002177_abnormal_outer_ear0.68982086
95MP0002429_abnormal_blood_cell0.68268810
96MP0009697_abnormal_copulation0.67952430
97MP0002111_abnormal_tail_morphology0.67814871
98MP0002234_abnormal_pharynx_morphology0.67778121
99MP0005384_cellular_phenotype0.66790480
100MP0003943_abnormal_hepatobiliary_system0.65572009
101MP0000358_abnormal_cell_content/0.65287636
102MP0002102_abnormal_ear_morphology0.65189508
103MP0005621_abnormal_cell_physiology0.64900537
104MP0004147_increased_porphyrin_level0.64833938
105MP0009250_abnormal_appendicular_skeleto0.64644736
106MP0001661_extended_life_span0.64105865
107MP0003115_abnormal_respiratory_system0.63644941
108MP0000858_altered_metastatic_potential0.63464497
109MP0002282_abnormal_trachea_morphology0.63266575
110MP0009703_decreased_birth_body0.62878849
111MP0003221_abnormal_cardiomyocyte_apopto0.62515328
112MP0002161_abnormal_fertility/fecundity0.62457242
113MP0000762_abnormal_tongue_morphology0.61782437
114MP0002092_abnormal_eye_morphology0.61725380
115MP0005391_vision/eye_phenotype0.61306865
116MP0000534_abnormal_ureter_morphology0.59746483
117MP0000049_abnormal_middle_ear0.58409461
118MP0005408_hypopigmentation0.57978182
119MP0000428_abnormal_craniofacial_morphol0.57560834
120MP0000566_synostosis0.56215115
121MP0008995_early_reproductive_senescence0.55568427
122MP0001286_abnormal_eye_development0.54855779
123MP0003699_abnormal_female_reproductive0.54719431
124MP0000015_abnormal_ear_pigmentation0.54705228
125MP0001919_abnormal_reproductive_system0.54359680
126MP0003186_abnormal_redox_activity0.54074778
127MP0003119_abnormal_digestive_system0.53373735
128MP0003938_abnormal_ear_development0.52763041
129MP0000716_abnormal_immune_system0.51664625
130MP0005075_abnormal_melanosome_morpholog0.49823716
131MP0009379_abnormal_foot_pigmentation0.49002276
132MP0006036_abnormal_mitochondrial_physio0.48959585
133MP0002163_abnormal_gland_morphology0.48222991
134MP0001915_intracranial_hemorrhage0.47663485

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.08521701
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.93827835
3Birth length less than 3rd percentile (HP:0003561)4.84010608
4Reticulocytopenia (HP:0001896)4.16097116
5Abnormality of chromosome stability (HP:0003220)4.01101826
6Patellar aplasia (HP:0006443)3.91343540
7Meckel diverticulum (HP:0002245)3.83148744
8Abnormality of the preputium (HP:0100587)3.81046123
9Colon cancer (HP:0003003)3.67717556
10Aplasia/Hypoplasia of the patella (HP:0006498)3.67347036
11Breast hypoplasia (HP:0003187)3.66296265
12Abnormality of the ileum (HP:0001549)3.65146214
13Cortical dysplasia (HP:0002539)3.57957754
14Duodenal stenosis (HP:0100867)3.56770706
15Small intestinal stenosis (HP:0012848)3.56770706
16Aplasia/Hypoplasia of the sacrum (HP:0008517)3.56238021
17Aplasia/Hypoplasia of the uvula (HP:0010293)3.49075810
18Oral leukoplakia (HP:0002745)3.47450852
19Impulsivity (HP:0100710)3.47096976
20Carpal bone hypoplasia (HP:0001498)3.43915915
21Abnormal lung lobation (HP:0002101)3.20906046
22Hypoplasia of the capital femoral epiphysis (HP:0003090)3.17601762
23Abnormal number of erythroid precursors (HP:0012131)3.15156326
24Abnormality of cells of the erythroid lineage (HP:0012130)3.10040203
25Increased nuchal translucency (HP:0010880)3.06809444
26Myelodysplasia (HP:0002863)3.02494019
27Abnormality of the anterior horn cell (HP:0006802)2.97182506
28Degeneration of anterior horn cells (HP:0002398)2.97182506
2911 pairs of ribs (HP:0000878)2.96156958
30Selective tooth agenesis (HP:0001592)2.95557562
31Aplastic anemia (HP:0001915)2.92667973
32Abnormality of the duodenum (HP:0002246)2.89387380
33Ectopic kidney (HP:0000086)2.87817631
34Nephroblastoma (Wilms tumor) (HP:0002667)2.85415402
35Sloping forehead (HP:0000340)2.81517890
36Absent radius (HP:0003974)2.78058566
37Medulloblastoma (HP:0002885)2.74260926
38Bone marrow hypocellularity (HP:0005528)2.73876390
39Duplicated collecting system (HP:0000081)2.71264416
40Rough bone trabeculation (HP:0100670)2.68992504
41Microretrognathia (HP:0000308)2.67873460
42Embryonal renal neoplasm (HP:0011794)2.66654061
43Abnormality of the carotid arteries (HP:0005344)2.66473682
44Abnormality of glycolysis (HP:0004366)2.65690965
45Absent thumb (HP:0009777)2.59603584
46Absent forearm bone (HP:0003953)2.58937526
47Aplasia involving forearm bones (HP:0009822)2.58937526
48Neoplasm of the pancreas (HP:0002894)2.56847080
49Increased serum pyruvate (HP:0003542)2.52184805
50Abnormality of the fetal cardiovascular system (HP:0010948)2.47990046
51Abnormal umbilical cord blood vessels (HP:0011403)2.47990046
52Single umbilical artery (HP:0001195)2.47990046
53Abnormality of the renal collecting system (HP:0004742)2.44688434
54Volvulus (HP:0002580)2.41228851
55Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38581854
56Horseshoe kidney (HP:0000085)2.38408752
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.36415802
58Absent epiphyses (HP:0010577)2.36415802
59Facial hemangioma (HP:0000329)2.33949940
60Tracheoesophageal fistula (HP:0002575)2.28685328
61Triphalangeal thumb (HP:0001199)2.28373149
62Clubbing of toes (HP:0100760)2.25383072
63Cafe-au-lait spot (HP:0000957)2.21619534
64Premature graying of hair (HP:0002216)2.20815586
65Short thumb (HP:0009778)2.20219718
66Abnormality of the umbilical cord (HP:0010881)2.18506818
67Abnormal number of incisors (HP:0011064)2.17948679
68Neoplasm of the colon (HP:0100273)2.15698578
69Pallor (HP:0000980)2.15294909
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12578926
71Short 4th metacarpal (HP:0010044)2.12578926
72Atresia of the external auditory canal (HP:0000413)2.12301406
73Ependymoma (HP:0002888)2.11013525
74Rhabdomyosarcoma (HP:0002859)2.10978437
75High pitched voice (HP:0001620)2.07176432
76Macrocytic anemia (HP:0001972)2.04835923
77Deep philtrum (HP:0002002)2.04744359
78Missing ribs (HP:0000921)2.04696857
79Microglossia (HP:0000171)2.04515673
80Irregular epiphyses (HP:0010582)2.02470467
81Aplasia/Hypoplasia of the sternum (HP:0006714)2.00672276
82Broad distal phalanx of finger (HP:0009836)1.99325677
83Agnosia (HP:0010524)1.99182063
84Proximal placement of thumb (HP:0009623)1.98516296
85Abnormality of DNA repair (HP:0003254)1.97968058
86Abnormal spermatogenesis (HP:0008669)1.96792632
87Ureteral duplication (HP:0000073)1.95448128
88Abnormality of the labia minora (HP:0012880)1.93840905
89Short middle phalanx of the 5th finger (HP:0004220)1.93829211
90Abnormal trabecular bone morphology (HP:0100671)1.92983026
91Squamous cell carcinoma (HP:0002860)1.91946533
92Embryonal neoplasm (HP:0002898)1.91852006
93Cleft eyelid (HP:0000625)1.90807749
94Hypoplastic pelvis (HP:0008839)1.90645954
95Duplication of thumb phalanx (HP:0009942)1.89462842
96Acute necrotizing encephalopathy (HP:0006965)1.88698226
97Supernumerary spleens (HP:0009799)1.88656176
98Cellular immunodeficiency (HP:0005374)1.87972394
99Small epiphyses (HP:0010585)1.86558222
100Deviation of the thumb (HP:0009603)1.86456696
101Abnormal mitochondria in muscle tissue (HP:0008316)1.85144893
102Slender long bone (HP:0003100)1.83656994
103Pancytopenia (HP:0001876)1.83343888
104Abnormal auditory evoked potentials (HP:0006958)1.82947573
105Ovarian neoplasm (HP:0100615)1.82128658
106Overlapping toe (HP:0001845)1.81875382
107Arteriovenous malformation (HP:0100026)1.80833045
108Prominent nose (HP:0000448)1.79375130
109Glossoptosis (HP:0000162)1.79214238
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78895484
111Glioma (HP:0009733)1.78246726
112Abnormality of the calcaneus (HP:0008364)1.76880015
113Choanal atresia (HP:0000453)1.76370675
114Cerebral hypomyelination (HP:0006808)1.75554452
115Lymphoma (HP:0002665)1.75182317
116Abnormality of pyrimidine metabolism (HP:0004353)1.74678392
117Microvesicular hepatic steatosis (HP:0001414)1.74089806
118Secondary amenorrhea (HP:0000869)1.73854607
119Abnormality of chromosome segregation (HP:0002916)1.73781465
120Acute encephalopathy (HP:0006846)1.73493876
121Abnormalities of placenta or umbilical cord (HP:0001194)1.71923911
122Oligodactyly (hands) (HP:0001180)1.71409651
123Abnormality of the proximal phalanges of the hand (HP:0009834)1.69584442
124Oligodactyly (HP:0012165)1.66876072
125Abnormality of the astrocytes (HP:0100707)1.65022630
126Astrocytoma (HP:0009592)1.65022630
127Progressive external ophthalmoplegia (HP:0000590)1.61818001
128Cholecystitis (HP:0001082)1.57273676
129Abnormal gallbladder physiology (HP:0012438)1.57273676
130Increased hepatocellular lipid droplets (HP:0006565)1.56849397
131Long clavicles (HP:0000890)1.56492451
132Intestinal polyposis (HP:0200008)1.54328468
133Insidious onset (HP:0003587)1.53211258
134Termporal pattern (HP:0011008)1.53211258
135Abnormality of cochlea (HP:0000375)1.51535448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.64211051
2WEE15.16912015
3CDC74.72936753
4NEK23.78830899
5BRSK23.51972722
6NEK13.24521961
7BRSK12.76086461
8EIF2AK12.67526778
9TTK2.65791614
10ACVR1B2.53557988
11SRPK12.48302111
12PLK12.39066998
13PLK42.30917392
14AURKB2.11254413
15VRK12.00827665
16VRK21.91397491
17PLK31.88047742
18MKNK11.76392556
19DYRK31.71940146
20ATR1.71611498
21PASK1.62551663
22CDK71.62382542
23CHEK21.62024380
24STK161.57582733
25PNCK1.54563049
26RPS6KA41.49095260
27STK41.45114499
28TSSK61.44270921
29MST1R1.41558502
30NME21.40089080
31EIF2AK31.39494422
32AURKA1.35957853
33TLK11.33368096
34MAP3K81.27232927
35CDK41.24176944
36TAF11.23146100
37MELK1.19192951
38MKNK21.18829329
39CHEK11.18203520
40MST41.18003037
41STK101.15891474
42TESK21.13238330
43EIF2AK20.97569701
44TGFBR10.91845334
45PDK20.91505288
46ZAK0.87293266
47ATM0.86662447
48CDK80.86055706
49STK30.85846637
50MET0.83973426
51PAK40.81643906
52TRIM280.79639604
53CDK20.78419310
54CLK10.77719149
55RPS6KB20.77199638
56PBK0.73421580
57* CDK10.72553985
58ERBB40.70449513
59SCYL20.69866047
60CDK60.68961374
61NME10.67105106
62TESK10.63968990
63PLK20.63235146
64BRAF0.62636944
65CSNK2A10.60732983
66SMG10.56690086
67PIM10.55020939
68PAK10.53704559
69LATS20.53487849
70LATS10.52355417
71NUAK10.52155246
72RPS6KA50.51928230
73YES10.51901187
74PDK40.51512315
75PDK30.51512315
76MARK30.50239031
77EEF2K0.49260541
78STK390.47616838
79CSNK2A20.47265213
80LRRK20.45712336
81MAP3K100.44718618
82NEK90.40664102
83BCR0.40505634
84RAF10.40318311
85CDK120.39491365
86* CCNB10.39368430
87MAPKAPK50.35931084
88DYRK1B0.33338561
89KSR10.33252979
90UHMK10.31173765
91CDK150.30262334
92CDK11A0.30008787
93STK38L0.29930610
94CDK180.29615421
95MINK10.27842884
96PRKCI0.27786775
97MAPK110.26255091
98MAP4K10.26077275
99BLK0.25899889
100FGFR10.25830837
101CSNK1E0.25579472
102BRD40.25544177
103PIM20.25306452
104PRKDC0.24943863
105CDK140.23630240
106ICK0.22366295
107AKT20.21835921
108ERBB30.21314071
109BTK0.20976180
110TEC0.20491651
111IRAK30.19159881
112TAOK20.18179772
113WNK40.18069054
114MAPK140.17893917
115LIMK10.17642192
116PAK20.17341314
117ALK0.16551185
118CDK90.16070210
119ILK0.15087762
120BCKDK0.14787346
121AKT10.14639072
122RPS6KC10.14569175
123RPS6KL10.14569175
124RPS6KA60.14390488
125KDR0.13198778
126MAPKAPK20.12246956
127EPHA20.11491031
128ERBB20.11474438
129CDK30.11148825

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.97624359
2Mismatch repair_Homo sapiens_hsa034304.94857838
3Homologous recombination_Homo sapiens_hsa034403.83720316
4Base excision repair_Homo sapiens_hsa034103.61790721
5Cell cycle_Homo sapiens_hsa041103.54245330
6Spliceosome_Homo sapiens_hsa030403.23457586
7Nucleotide excision repair_Homo sapiens_hsa034203.14762515
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13393202
9RNA transport_Homo sapiens_hsa030132.97004895
10Fanconi anemia pathway_Homo sapiens_hsa034602.78903263
11Proteasome_Homo sapiens_hsa030502.75083364
12RNA polymerase_Homo sapiens_hsa030202.65098762
13Pyrimidine metabolism_Homo sapiens_hsa002402.55933039
14Ribosome_Homo sapiens_hsa030102.53124023
15One carbon pool by folate_Homo sapiens_hsa006702.28713137
16Non-homologous end-joining_Homo sapiens_hsa034502.21222289
17p53 signaling pathway_Homo sapiens_hsa041152.00328225
18Basal transcription factors_Homo sapiens_hsa030221.91037743
19RNA degradation_Homo sapiens_hsa030181.84228331
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82896520
21mRNA surveillance pathway_Homo sapiens_hsa030151.68232538
22Pyruvate metabolism_Homo sapiens_hsa006201.44230508
23Oocyte meiosis_Homo sapiens_hsa041141.42966660
24Systemic lupus erythematosus_Homo sapiens_hsa053221.41258715
25Purine metabolism_Homo sapiens_hsa002301.35576396
26Vitamin B6 metabolism_Homo sapiens_hsa007501.32303028
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24146256
28Oxidative phosphorylation_Homo sapiens_hsa001901.12610955
29Epstein-Barr virus infection_Homo sapiens_hsa051691.11849717
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11275695
31Viral carcinogenesis_Homo sapiens_hsa052030.99185964
32Steroid biosynthesis_Homo sapiens_hsa001000.94580407
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90334675
34Herpes simplex infection_Homo sapiens_hsa051680.89697201
35Pentose phosphate pathway_Homo sapiens_hsa000300.79997873
36Folate biosynthesis_Homo sapiens_hsa007900.79457034
37Propanoate metabolism_Homo sapiens_hsa006400.79095661
38HTLV-I infection_Homo sapiens_hsa051660.79076319
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78616358
40Fatty acid elongation_Homo sapiens_hsa000620.77290713
41Antigen processing and presentation_Homo sapiens_hsa046120.76653754
42Small cell lung cancer_Homo sapiens_hsa052220.73631452
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72389870
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.71438875
45Selenocompound metabolism_Homo sapiens_hsa004500.70181591
46MicroRNAs in cancer_Homo sapiens_hsa052060.69259061
47Alzheimers disease_Homo sapiens_hsa050100.68413437
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60223784
49Protein export_Homo sapiens_hsa030600.58991435
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.56318073
51Alcoholism_Homo sapiens_hsa050340.56282127
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55800582
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.55410563
54Glutathione metabolism_Homo sapiens_hsa004800.54076379
55Biosynthesis of amino acids_Homo sapiens_hsa012300.53974601
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53163500
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48921803
58N-Glycan biosynthesis_Homo sapiens_hsa005100.48912563
59Legionellosis_Homo sapiens_hsa051340.47519851
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46921959
61Huntingtons disease_Homo sapiens_hsa050160.44863605
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44544900
63Hepatitis B_Homo sapiens_hsa051610.42865352
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40233907
65Thyroid cancer_Homo sapiens_hsa052160.39452151
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.38094562
67Apoptosis_Homo sapiens_hsa042100.37233973
68Primary immunodeficiency_Homo sapiens_hsa053400.36205152
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35005886
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34215286
71Fatty acid metabolism_Homo sapiens_hsa012120.33981278
72Colorectal cancer_Homo sapiens_hsa052100.33944196
73Carbon metabolism_Homo sapiens_hsa012000.33811715
74Bladder cancer_Homo sapiens_hsa052190.32783919
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31471024
76Measles_Homo sapiens_hsa051620.29888331
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29875864
78Hippo signaling pathway_Homo sapiens_hsa043900.29322717
79Arginine and proline metabolism_Homo sapiens_hsa003300.29223204
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29221587
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29105873
82Wnt signaling pathway_Homo sapiens_hsa043100.28909683
83Sulfur relay system_Homo sapiens_hsa041220.28702234
84Chronic myeloid leukemia_Homo sapiens_hsa052200.25894808
85TGF-beta signaling pathway_Homo sapiens_hsa043500.24543970
86Melanoma_Homo sapiens_hsa052180.21985799
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20851459
88Parkinsons disease_Homo sapiens_hsa050120.20678120
89FoxO signaling pathway_Homo sapiens_hsa040680.19797490
90Influenza A_Homo sapiens_hsa051640.19765507
91Shigellosis_Homo sapiens_hsa051310.19134618
92Pancreatic cancer_Homo sapiens_hsa052120.18778397
93Basal cell carcinoma_Homo sapiens_hsa052170.18336686
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17770962
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.16433933
96Pathways in cancer_Homo sapiens_hsa052000.16002114
97Metabolic pathways_Homo sapiens_hsa011000.15851164
98Sulfur metabolism_Homo sapiens_hsa009200.15735062
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15325207
100Non-small cell lung cancer_Homo sapiens_hsa052230.14750393
101Prostate cancer_Homo sapiens_hsa052150.14041227
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.13330812
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13123275
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.13079398
105Arginine biosynthesis_Homo sapiens_hsa002200.12009056
106Notch signaling pathway_Homo sapiens_hsa043300.11976980
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11378129
108Tyrosine metabolism_Homo sapiens_hsa003500.11066040
109Renin-angiotensin system_Homo sapiens_hsa046140.10761615
110Viral myocarditis_Homo sapiens_hsa054160.10732039
111Lysine degradation_Homo sapiens_hsa003100.10656861
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07835936
113Proteoglycans in cancer_Homo sapiens_hsa052050.07133689
114Hedgehog signaling pathway_Homo sapiens_hsa043400.06986842
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06945600
116Fructose and mannose metabolism_Homo sapiens_hsa000510.06686899
117Hematopoietic cell lineage_Homo sapiens_hsa046400.05988961
118Arachidonic acid metabolism_Homo sapiens_hsa005900.05195135
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04687260
120Adherens junction_Homo sapiens_hsa045200.04318884
121HIF-1 signaling pathway_Homo sapiens_hsa040660.03884366
122Galactose metabolism_Homo sapiens_hsa000520.00895774
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.00792029

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