PBDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.42450265
2chaperone-mediated protein transport (GO:0072321)5.81297837
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.73985119
4ATP synthesis coupled proton transport (GO:0015986)5.44791497
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.44791497
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.24422172
7respiratory electron transport chain (GO:0022904)4.84186999
8electron transport chain (GO:0022900)4.72547350
9protein complex biogenesis (GO:0070271)4.70294555
10protein localization to kinetochore (GO:0034501)4.65442708
11DNA replication checkpoint (GO:0000076)4.65168527
12protein neddylation (GO:0045116)4.58298746
13mitochondrial respiratory chain complex assembly (GO:0033108)4.52865583
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.46844765
15NADH dehydrogenase complex assembly (GO:0010257)4.46844765
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.46844765
17rRNA modification (GO:0000154)4.38322436
18formation of translation preinitiation complex (GO:0001731)4.37497205
19ribosomal small subunit biogenesis (GO:0042274)4.31442049
20regulation of mitochondrial translation (GO:0070129)4.30183461
21regulation of nuclear cell cycle DNA replication (GO:0033262)4.24139892
22DNA replication initiation (GO:0006270)4.18418900
23respiratory chain complex IV assembly (GO:0008535)4.15526877
24ribosome biogenesis (GO:0042254)4.09965076
25establishment of integrated proviral latency (GO:0075713)4.09520661
26proteasome assembly (GO:0043248)4.01564443
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.01355545
28DNA strand elongation involved in DNA replication (GO:0006271)4.01191301
29ribonucleoprotein complex biogenesis (GO:0022613)3.98565542
30ribosomal small subunit assembly (GO:0000028)3.96330938
31telomere maintenance via semi-conservative replication (GO:0032201)3.93862055
32cytochrome complex assembly (GO:0017004)3.91857687
33maturation of SSU-rRNA (GO:0030490)3.91418609
34daunorubicin metabolic process (GO:0044597)3.89262076
35polyketide metabolic process (GO:0030638)3.89262076
36doxorubicin metabolic process (GO:0044598)3.89262076
37DNA deamination (GO:0045006)3.89137211
38DNA replication-dependent nucleosome assembly (GO:0006335)3.88954050
39DNA replication-dependent nucleosome organization (GO:0034723)3.88954050
40protein localization to chromosome, centromeric region (GO:0071459)3.88486295
41cullin deneddylation (GO:0010388)3.87292752
42CENP-A containing nucleosome assembly (GO:0034080)3.84330089
43regulation of cellular amino acid metabolic process (GO:0006521)3.83180064
44rRNA methylation (GO:0031167)3.81849303
45DNA strand elongation (GO:0022616)3.81144608
46pseudouridine synthesis (GO:0001522)3.77313045
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.76209363
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.76209363
49chromatin remodeling at centromere (GO:0031055)3.74102077
50water-soluble vitamin biosynthetic process (GO:0042364)3.73799174
51mitotic sister chromatid segregation (GO:0000070)3.71458830
52mitotic metaphase plate congression (GO:0007080)3.66331145
53regulation of mitotic spindle checkpoint (GO:1903504)3.60662154
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60662154
55telomere maintenance via recombination (GO:0000722)3.59644388
56protein deneddylation (GO:0000338)3.57758333
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.55099203
58nucleobase biosynthetic process (GO:0046112)3.55089808
59protein targeting to mitochondrion (GO:0006626)3.54673046
60ribosomal large subunit biogenesis (GO:0042273)3.53572391
61DNA unwinding involved in DNA replication (GO:0006268)3.47390895
62rRNA processing (GO:0006364)3.47229257
63mitotic recombination (GO:0006312)3.46669207
64negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44194714
65establishment of viral latency (GO:0019043)3.43683008
66DNA replication-independent nucleosome organization (GO:0034724)3.41059308
67DNA replication-independent nucleosome assembly (GO:0006336)3.41059308
68establishment of protein localization to mitochondrion (GO:0072655)3.40527116
69purine nucleobase biosynthetic process (GO:0009113)3.40319058
70viral transcription (GO:0019083)3.40053324
71positive regulation of ligase activity (GO:0051351)3.37032890
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.36916730
73protein localization to mitochondrion (GO:0070585)3.36668005
74translational termination (GO:0006415)3.35786090
75rRNA metabolic process (GO:0016072)3.34213504
76regulation of translation in response to stress (GO:0043555)3.31492400
77transcription from RNA polymerase I promoter (GO:0006360)3.29788102
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29501623
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28102031
80kinetochore organization (GO:0051383)3.27505379
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.27068279
82attachment of spindle microtubules to kinetochore (GO:0008608)3.26685517
83transcription elongation from RNA polymerase III promoter (GO:0006385)3.26345712
84termination of RNA polymerase III transcription (GO:0006386)3.26345712
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.25951013
86histone mRNA metabolic process (GO:0008334)3.23432842
87hydrogen ion transmembrane transport (GO:1902600)3.21684089
88spliceosomal snRNP assembly (GO:0000387)3.21060694
89regulation of ubiquitin-protein transferase activity (GO:0051438)3.20392507
90metaphase plate congression (GO:0051310)3.20209796
91DNA double-strand break processing (GO:0000729)3.15833579
92kinetochore assembly (GO:0051382)3.15653056
93cellular component biogenesis (GO:0044085)3.14478034
94regulation of telomere maintenance via telomerase (GO:0032210)3.13657347
95ribosome assembly (GO:0042255)3.12890871
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.12753882
97negative regulation of ligase activity (GO:0051352)3.12753882
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12570691
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12516550
100telomere maintenance via telomere lengthening (GO:0010833)3.11691616
101spliceosomal complex assembly (GO:0000245)3.10964153
102DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10224673
103sister chromatid segregation (GO:0000819)3.09779015
104protein-cofactor linkage (GO:0018065)3.09732465
105nuclear pore organization (GO:0006999)3.08740680
106peptidyl-histidine modification (GO:0018202)3.08288425
107translational initiation (GO:0006413)3.07870207
108cotranslational protein targeting to membrane (GO:0006613)3.07122745
109regulation of ligase activity (GO:0051340)3.06649506
110rRNA transcription (GO:0009303)3.06437051
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06367567
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06367567
113signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.05384686
114signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.05384686
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.05384686
116histone exchange (GO:0043486)3.05321350
117protein targeting to ER (GO:0045047)3.04435182
118DNA damage response, detection of DNA damage (GO:0042769)3.04176372
119regulation of helicase activity (GO:0051095)3.03708333
120nuclear pore complex assembly (GO:0051292)3.02129783
121translation (GO:0006412)3.00860399
122mitotic nuclear envelope disassembly (GO:0007077)3.00705990
123inner mitochondrial membrane organization (GO:0007007)3.00601672
124transcription-coupled nucleotide-excision repair (GO:0006283)2.98621918
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.98511095
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98511095
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97957495
128negative regulation of protein ubiquitination (GO:0031397)2.97268939
129nucleotide-excision repair, DNA gap filling (GO:0006297)2.96729153
130signal transduction involved in cell cycle checkpoint (GO:0072395)2.95455762
1317-methylguanosine mRNA capping (GO:0006370)2.95305627
132cell cycle G1/S phase transition (GO:0044843)2.94636030
133G1/S transition of mitotic cell cycle (GO:0000082)2.94636030
134mitotic chromosome condensation (GO:0007076)2.93471438
135translational elongation (GO:0006414)2.92890676
136RNA capping (GO:0036260)2.91582778
1377-methylguanosine RNA capping (GO:0009452)2.91582778
138oxidative phosphorylation (GO:0006119)2.91427314
139proton transport (GO:0015992)2.90232878
140negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.89714694
141nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89311818
142termination of RNA polymerase I transcription (GO:0006363)2.89061905
143ATP biosynthetic process (GO:0006754)2.88862162
144protein localization to endoplasmic reticulum (GO:0070972)2.88658297
145intracellular protein transmembrane import (GO:0044743)2.88587584
146transcription elongation from RNA polymerase I promoter (GO:0006362)2.87955731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.57369983
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.09746603
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82315554
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66425750
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57788205
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.34372710
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.27321575
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.26898551
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.08949815
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05027021
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01868087
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99684839
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.88233558
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.83655560
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83530797
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.79977327
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.68372462
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38877700
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38877700
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38877700
21VDR_23849224_ChIP-Seq_CD4+_Human2.31864127
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29179465
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.20974422
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14206011
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12781052
26XRN2_22483619_ChIP-Seq_HELA_Human2.11809983
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09245348
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07246269
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07051891
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06957505
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03386192
32FOXP3_21729870_ChIP-Seq_TREG_Human2.01522170
33ELK1_19687146_ChIP-ChIP_HELA_Human1.95521018
34DCP1A_22483619_ChIP-Seq_HELA_Human1.93757199
35VDR_22108803_ChIP-Seq_LS180_Human1.91386835
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.84139290
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.83122749
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80007667
39GABP_19822575_ChIP-Seq_HepG2_Human1.79034422
40EWS_26573619_Chip-Seq_HEK293_Human1.78999531
41TTF2_22483619_ChIP-Seq_HELA_Human1.77513442
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73870244
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71315296
44FUS_26573619_Chip-Seq_HEK293_Human1.70617006
45AR_21909140_ChIP-Seq_LNCAP_Human1.70248563
46ZNF274_21170338_ChIP-Seq_K562_Hela1.69862217
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69407693
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67102610
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65419341
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63338720
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.60831297
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.60308200
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53045705
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51068745
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.50765354
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49500609
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49298800
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48630869
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.48503299
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47310695
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43278078
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.42391589
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41318413
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40666629
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40122196
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39181758
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37034260
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37013705
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35271668
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32976710
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32404289
72KDM5A_27292631_Chip-Seq_BREAST_Human1.28113566
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27169739
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26985513
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25570321
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.24441559
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22454833
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20359180
79P300_19829295_ChIP-Seq_ESCs_Human1.17784725
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17626886
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.17132180
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17061593
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16970392
84IRF1_19129219_ChIP-ChIP_H3396_Human1.16933648
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16770122
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16261199
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14112889
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13954326
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13641377
90POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13410828
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13268037
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10619226
93CIITA_25753668_ChIP-Seq_RAJI_Human1.09147023
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08119746
95TFEB_21752829_ChIP-Seq_HELA_Human1.07583166
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05266023
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03643518
98EGR1_19374776_ChIP-ChIP_THP-1_Human1.02875513
99SPI1_23547873_ChIP-Seq_NB4_Human1.02230942
100TAF15_26573619_Chip-Seq_HEK293_Human1.01673079
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99999813
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97156847
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96934690
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96458120
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95826255
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95722149
107MYC_18940864_ChIP-ChIP_HL60_Human0.94886544
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94782512
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93851749
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93154936
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92879723
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92827772
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92303188
114TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90702599
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88548944
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88505431
117TP53_22573176_ChIP-Seq_HFKS_Human0.88446886
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87031939
119IGF1R_20145208_ChIP-Seq_DFB_Human0.86626492
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86317679
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85900006
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85603737
123NANOG_19829295_ChIP-Seq_ESCs_Human0.85063221
124SOX2_19829295_ChIP-Seq_ESCs_Human0.85063221
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84784754
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82963609
127ELF5_23300383_ChIP-Seq_T47D_Human0.82778947
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82632041
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82191746
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.80900222
131EZH2_27294783_Chip-Seq_NPCs_Mouse0.80848175
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80580069
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.79732596
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78948276
135FOXA1_25329375_ChIP-Seq_VCAP_Human0.78948276
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.78591794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.54154403
2MP0003693_abnormal_embryo_hatching4.50788402
3MP0008057_abnormal_DNA_replication4.15317446
4MP0010094_abnormal_chromosome_stability3.77351560
5MP0003111_abnormal_nucleus_morphology3.58966284
6MP0003077_abnormal_cell_cycle3.51241845
7MP0006292_abnormal_olfactory_placode3.39228276
8MP0008058_abnormal_DNA_repair3.05745133
9MP0008932_abnormal_embryonic_tissue2.55101345
10MP0008007_abnormal_cellular_replicative2.53002516
11MP0006072_abnormal_retinal_apoptosis2.48892634
12MP0003123_paternal_imprinting2.39335359
13MP0001529_abnormal_vocalization2.30254922
14MP0009697_abnormal_copulation2.28654393
15MP0003890_abnormal_embryonic-extraembry2.25658905
16MP0005084_abnormal_gallbladder_morpholo2.15687604
17MP0005075_abnormal_melanosome_morpholog2.06295059
18MP0002396_abnormal_hematopoietic_system2.05584961
19MP0000350_abnormal_cell_proliferation2.00930835
20MP0003195_calcinosis2.00731994
21MP0003786_premature_aging1.93950436
22MP0002837_dystrophic_cardiac_calcinosis1.93412615
23MP0001485_abnormal_pinna_reflex1.82928690
24MP0001730_embryonic_growth_arrest1.73506185
25MP0001672_abnormal_embryogenesis/_devel1.67997828
26MP0005380_embryogenesis_phenotype1.67997828
27MP0003121_genomic_imprinting1.67695912
28MP0003011_delayed_dark_adaptation1.65846744
29MP0004264_abnormal_extraembryonic_tissu1.62141702
30MP0002102_abnormal_ear_morphology1.56716461
31MP0003136_yellow_coat_color1.55799328
32MP0001293_anophthalmia1.55624311
33MP0002736_abnormal_nociception_after1.54415897
34MP0003718_maternal_effect1.50023199
35MP0000490_abnormal_crypts_of1.49906187
36MP0003984_embryonic_growth_retardation1.49368730
37MP0010352_gastrointestinal_tract_polyps1.48549985
38MP0003315_abnormal_perineum_morphology1.47571843
39MP0002088_abnormal_embryonic_growth/wei1.46707635
40MP0003186_abnormal_redox_activity1.46108315
41MP0000313_abnormal_cell_death1.44968183
42MP0006035_abnormal_mitochondrial_morpho1.43069952
43MP0002090_abnormal_vision1.42535923
44MP0002163_abnormal_gland_morphology1.41472003
45MP0001984_abnormal_olfaction1.39437028
46MP0001764_abnormal_homeostasis1.35347133
47MP0001697_abnormal_embryo_size1.33516083
48MP0002638_abnormal_pupillary_reflex1.29982039
49MP0008877_abnormal_DNA_methylation1.28205970
50MP0009333_abnormal_splenocyte_physiolog1.28071799
51MP0010030_abnormal_orbit_morphology1.26955761
52MP0002277_abnormal_respiratory_mucosa1.26765531
53MP0005257_abnormal_intraocular_pressure1.25601595
54MP0002132_abnormal_respiratory_system1.24862975
55MP0003567_abnormal_fetal_cardiomyocyte1.24692319
56MP0002085_abnormal_embryonic_tissue1.23299672
57MP0005253_abnormal_eye_physiology1.22180200
58MP0002254_reproductive_system_inflammat1.22091816
59MP0004142_abnormal_muscle_tone1.21161026
60MP0002080_prenatal_lethality1.21095629
61MP0002019_abnormal_tumor_incidence1.19762361
62MP0005499_abnormal_olfactory_system1.14623873
63MP0005394_taste/olfaction_phenotype1.14623873
64MP0002086_abnormal_extraembryonic_tissu1.13543469
65MP0002233_abnormal_nose_morphology1.10423253
66MP0001188_hyperpigmentation1.09601180
67MP0008995_early_reproductive_senescence1.08877510
68MP0005551_abnormal_eye_electrophysiolog1.05819176
69MP0000372_irregular_coat_pigmentation1.05521743
70MP0005379_endocrine/exocrine_gland_phen1.04925757
71MP0003938_abnormal_ear_development1.04675486
72MP0002084_abnormal_developmental_patter1.03966086
73MP0000631_abnormal_neuroendocrine_gland1.03926004
74MP0005408_hypopigmentation1.03076076
75MP0002332_abnormal_exercise_endurance1.03022276
76MP0002938_white_spotting1.00723793
77MP0010386_abnormal_urinary_bladder0.99672808
78MP0004147_increased_porphyrin_level0.99633474
79MP0001835_abnormal_antigen_presentation0.99145190
80MP0004381_abnormal_hair_follicle0.98511471
81MP0002282_abnormal_trachea_morphology0.97599603
82MP0000358_abnormal_cell_content/0.96673278
83MP0005671_abnormal_response_to0.95930432
84MP0001853_heart_inflammation0.95165285
85MP0000647_abnormal_sebaceous_gland0.93387870
86MP0002210_abnormal_sex_determination0.93209591
87MP0004197_abnormal_fetal_growth/weight/0.93115222
88MP0000049_abnormal_middle_ear0.92461184
89MP0002398_abnormal_bone_marrow0.92241073
90MP0002722_abnormal_immune_system0.90759241
91MP0003122_maternal_imprinting0.90704190
92MP0004215_abnormal_myocardial_fiber0.90696619
93MP0000689_abnormal_spleen_morphology0.90549157
94MP0004808_abnormal_hematopoietic_stem0.89719900
95MP0006082_CNS_inflammation0.89703677
96MP0001145_abnormal_male_reproductive0.88425113
97MP0001929_abnormal_gametogenesis0.88160368
98MP0003941_abnormal_skin_development0.87861837
99MP0000858_altered_metastatic_potential0.86759597
100MP0008875_abnormal_xenobiotic_pharmacok0.86406347
101MP0003448_altered_tumor_morphology0.85585599
102MP0000653_abnormal_sex_gland0.85050395
103MP0009046_muscle_twitch0.84260588
104MP0001968_abnormal_touch/_nociception0.83502352
105MP0002429_abnormal_blood_cell0.82941308
106MP0008872_abnormal_physiological_respon0.82573453
107MP0005397_hematopoietic_system_phenotyp0.81887208
108MP0001545_abnormal_hematopoietic_system0.81887208
109MP0002139_abnormal_hepatobiliary_system0.81841612
110MP0005332_abnormal_amino_acid0.80726328
111MP0002092_abnormal_eye_morphology0.80386507
112MP0001919_abnormal_reproductive_system0.79902653
113MP0005391_vision/eye_phenotype0.79722114
114MP0009785_altered_susceptibility_to0.79345147
115MP0004133_heterotaxia0.78712613
116MP0001905_abnormal_dopamine_level0.78060314
117MP0006276_abnormal_autonomic_nervous0.77744155
118MP0002697_abnormal_eye_size0.76238967
119MP0002653_abnormal_ependyma_morphology0.76107149
120MP0005389_reproductive_system_phenotype0.76034534
121MP0000703_abnormal_thymus_morphology0.76001470
122MP0003937_abnormal_limbs/digits/tail_de0.75379230
123MP0005195_abnormal_posterior_eye0.74540511
124MP0008789_abnormal_olfactory_epithelium0.74001293
125MP0005384_cellular_phenotype0.73443139
126MP0002111_abnormal_tail_morphology0.73222029
127MP0006036_abnormal_mitochondrial_physio0.73065975
128MP0003119_abnormal_digestive_system0.72299955
129MP0000716_abnormal_immune_system0.72211636
130MP0005000_abnormal_immune_tolerance0.70578529
131MP0002160_abnormal_reproductive_system0.70241420
132MP0005266_abnormal_metabolism0.70204606
133MP0010307_abnormal_tumor_latency0.70104623
134MP0003436_decreased_susceptibility_to0.69980914
135MP0003763_abnormal_thymus_physiology0.69699928
136MP0009379_abnormal_foot_pigmentation0.69682778
137MP0000428_abnormal_craniofacial_morphol0.69215142
138MP0001324_abnormal_eye_pigmentation0.68593309
139MP0002751_abnormal_autonomic_nervous0.67955890
140MP0004742_abnormal_vestibular_system0.67776451
141MP0000432_abnormal_head_morphology0.67683998
142MP0001286_abnormal_eye_development0.67436947
143MP0001800_abnormal_humoral_immune0.67273769
144MP0005410_abnormal_fertilization0.66919118
145MP0003806_abnormal_nucleotide_metabolis0.66851516
146MP0002127_abnormal_cardiovascular_syste0.66841099
147MP0003137_abnormal_impulse_conducting0.66309169
148MP0003755_abnormal_palate_morphology0.66192280
149MP0005395_other_phenotype0.65747647
150MP0002452_abnormal_antigen_presenting0.65074706
151MP0002420_abnormal_adaptive_immunity0.64542312

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.38544408
2Mitochondrial inheritance (HP:0001427)4.77382005
3Acute encephalopathy (HP:0006846)4.68591732
4Increased hepatocellular lipid droplets (HP:0006565)4.64041814
5Abnormal mitochondria in muscle tissue (HP:0008316)4.60825412
6Progressive macrocephaly (HP:0004481)4.49189786
7Increased CSF lactate (HP:0002490)4.34665735
8Lipid accumulation in hepatocytes (HP:0006561)4.19345176
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17548462
10Chromsome breakage (HP:0040012)3.98817033
11Hepatocellular necrosis (HP:0001404)3.97964179
12Birth length less than 3rd percentile (HP:0003561)3.88100659
13Abnormality of cells of the erythroid lineage (HP:0012130)3.69925759
14Renal Fanconi syndrome (HP:0001994)3.69920860
15Hepatic necrosis (HP:0002605)3.59096232
16Multiple enchondromatosis (HP:0005701)3.58080686
17Abnormal number of erythroid precursors (HP:0012131)3.56248288
18Congenital, generalized hypertrichosis (HP:0004540)3.46211033
19Bilateral microphthalmos (HP:0007633)3.45487629
20Meckel diverticulum (HP:0002245)3.45467802
21Septo-optic dysplasia (HP:0100842)3.44234614
22Cerebral edema (HP:0002181)3.40028166
23Aplastic anemia (HP:0001915)3.38719601
24Abnormality of the ileum (HP:0001549)3.24484978
25Breast hypoplasia (HP:0003187)3.21482288
26Rough bone trabeculation (HP:0100670)3.16379168
27Reticulocytopenia (HP:0001896)3.14635246
28Abnormal lung lobation (HP:0002101)3.11911220
29Type I transferrin isoform profile (HP:0003642)3.08126020
30Nephroblastoma (Wilms tumor) (HP:0002667)3.06982618
31Abnormality of the preputium (HP:0100587)3.06513637
32Trismus (HP:0000211)3.02346258
33Methylmalonic acidemia (HP:0002912)3.02007624
34Aplasia/Hypoplasia of the uvula (HP:0010293)3.00866082
35Exertional dyspnea (HP:0002875)2.99088853
36Carpal bone hypoplasia (HP:0001498)2.97299914
373-Methylglutaconic aciduria (HP:0003535)2.95015972
38Supernumerary spleens (HP:0009799)2.91705281
39Embryonal renal neoplasm (HP:0011794)2.89287971
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87536642
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87536642
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83872120
43Methylmalonic aciduria (HP:0012120)2.79423340
44Increased serum lactate (HP:0002151)2.77421607
45Rhabdomyosarcoma (HP:0002859)2.77204235
46Respiratory failure (HP:0002878)2.75632520
47Glossoptosis (HP:0000162)2.74103694
48Ependymoma (HP:0002888)2.73597734
49Cerebral hypomyelination (HP:0006808)2.72318956
50Lactic acidosis (HP:0003128)2.71879053
51Respiratory difficulties (HP:0002880)2.69488419
52Patellar aplasia (HP:0006443)2.69308685
53Abnormality of chromosome stability (HP:0003220)2.67153957
54Impulsivity (HP:0100710)2.64320281
55Bone marrow hypocellularity (HP:0005528)2.63347378
56Oral leukoplakia (HP:0002745)2.62974929
57Cleft eyelid (HP:0000625)2.62935725
58Myelodysplasia (HP:0002863)2.62123162
59Optic disc pallor (HP:0000543)2.61443266
60Small intestinal stenosis (HP:0012848)2.60290474
61Duodenal stenosis (HP:0100867)2.60290474
62Rib fusion (HP:0000902)2.60277179
63Pancreatic cysts (HP:0001737)2.57958459
64Pallor (HP:0000980)2.55327129
65Increased intramyocellular lipid droplets (HP:0012240)2.54699174
66Microretrognathia (HP:0000308)2.53242208
67Reduced antithrombin III activity (HP:0001976)2.52748288
68Aplasia/Hypoplasia of the patella (HP:0006498)2.52018634
69Pancreatic fibrosis (HP:0100732)2.50427295
70Absent septum pellucidum (HP:0001331)2.49605779
71Abnormality of methionine metabolism (HP:0010901)2.47532865
72Abnormality of the labia minora (HP:0012880)2.46927091
73Leukodystrophy (HP:0002415)2.46250910
74Poor head control (HP:0002421)2.45709869
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.44845412
76Hypoplasia of the fovea (HP:0007750)2.44845412
77Fused cervical vertebrae (HP:0002949)2.44526769
78Medial flaring of the eyebrow (HP:0010747)2.42852266
79Abnormality of renal resorption (HP:0011038)2.42199940
80Degeneration of anterior horn cells (HP:0002398)2.40895289
81Abnormality of the anterior horn cell (HP:0006802)2.40895289
82Selective tooth agenesis (HP:0001592)2.38759071
83Irregular epiphyses (HP:0010582)2.38729437
84Medulloblastoma (HP:0002885)2.37800846
85Secondary amenorrhea (HP:0000869)2.37237488
86Abnormal trabecular bone morphology (HP:0100671)2.36525825
87Hyperglycinemia (HP:0002154)2.36360329
88Lethargy (HP:0001254)2.35749075
89Macrocytic anemia (HP:0001972)2.35001465
90True hermaphroditism (HP:0010459)2.34128552
91Sparse eyelashes (HP:0000653)2.33210445
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31173130
93Abnormality of alanine metabolism (HP:0010916)2.31173130
94Hyperalaninemia (HP:0003348)2.31173130
95Premature graying of hair (HP:0002216)2.30607853
96Exercise intolerance (HP:0003546)2.30549367
97Triphalangeal thumb (HP:0001199)2.30186635
98Colon cancer (HP:0003003)2.29204252
99Abnormality of serum amino acid levels (HP:0003112)2.27916133
100Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26970008
101Microvesicular hepatic steatosis (HP:0001414)2.24326253
102Agnosia (HP:0010524)2.22736790
103Abnormality of urine glucose concentration (HP:0011016)2.22100730
104Glycosuria (HP:0003076)2.22100730
105Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21867239
106Abnormality of the septum pellucidum (HP:0007375)2.21245382
107Sloping forehead (HP:0000340)2.20463608
108Rectovaginal fistula (HP:0000143)2.20372498
109Rectal fistula (HP:0100590)2.20372498
110Premature ovarian failure (HP:0008209)2.19643621
111Atresia of the external auditory canal (HP:0000413)2.19626635
112Hypochromic microcytic anemia (HP:0004840)2.17765490
113Absent radius (HP:0003974)2.17219053
114Abnormality of glycolysis (HP:0004366)2.16831982
115Increased serum pyruvate (HP:0003542)2.16831982
116Congenital primary aphakia (HP:0007707)2.15671276
117Facial cleft (HP:0002006)2.14191627
118Optic nerve hypoplasia (HP:0000609)2.13909476
119Neoplasm of striated muscle (HP:0009728)2.13350280
120Tracheoesophageal fistula (HP:0002575)2.10819041
121Nephrogenic diabetes insipidus (HP:0009806)2.09663530
122Abnormality of the duodenum (HP:0002246)2.08239887
123Molar tooth sign on MRI (HP:0002419)2.06194040
124Abnormality of midbrain morphology (HP:0002418)2.06194040
125Gait imbalance (HP:0002141)2.05618726
126Aplasia/hypoplasia of the humerus (HP:0006507)2.05108526
127Amniotic constriction ring (HP:0009775)2.04372173
128Abnormality of placental membranes (HP:0011409)2.04372173
129X-linked dominant inheritance (HP:0001423)2.03500724
130CNS demyelination (HP:0007305)2.01698369
131Maternal diabetes (HP:0009800)2.00558663
132Absent forearm bone (HP:0003953)1.97073488
133Aplasia involving forearm bones (HP:0009822)1.97073488
134Genital tract atresia (HP:0001827)1.96799109
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96788902
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.96712856
137Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95652120
138Increased muscle lipid content (HP:0009058)1.94776468
139Vaginal atresia (HP:0000148)1.94048727
140Progressive muscle weakness (HP:0003323)1.92878337
141Megaloblastic anemia (HP:0001889)1.90696012
142Hyperglycinuria (HP:0003108)1.90151283
14311 pairs of ribs (HP:0000878)1.89551210
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.89074811
145Testicular atrophy (HP:0000029)1.88951348
146Abnormality of the pons (HP:0007361)1.88384399
147Hyperphosphaturia (HP:0003109)1.87753649
148Abnormal protein glycosylation (HP:0012346)1.87202277
149Abnormal glycosylation (HP:0012345)1.87202277
150Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87202277
151Abnormal protein N-linked glycosylation (HP:0012347)1.87202277
152Anophthalmia (HP:0000528)1.87077858
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86797581
154Absent thumb (HP:0009777)1.86566212
155Pancytopenia (HP:0001876)1.85196184
156Abnormality of serine family amino acid metabolism (HP:0010894)1.83512561
157Abnormality of glycine metabolism (HP:0010895)1.83512561
158Hypoglycemic coma (HP:0001325)1.82256759
159Pendular nystagmus (HP:0012043)1.81905918
160Horseshoe kidney (HP:0000085)1.81027444
161Hypothermia (HP:0002045)1.80912992
162Stenosis of the external auditory canal (HP:0000402)1.80374743
163Hyperinsulinemic hypoglycemia (HP:0000825)1.80193764
164Abnormality of the heme biosynthetic pathway (HP:0010472)1.79671272
165Sclerocornea (HP:0000647)1.79333662
166Cellular immunodeficiency (HP:0005374)1.78582539
167Nephronophthisis (HP:0000090)1.78528535
168Tongue fasciculations (HP:0001308)1.77609345
169Flat capital femoral epiphysis (HP:0003370)1.77570812
170Abnormal number of incisors (HP:0011064)1.76692505
171Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76502146
172Hepatoblastoma (HP:0002884)1.76275575
173Intestinal fistula (HP:0100819)1.75105534
174Abnormality of the fovea (HP:0000493)1.74971980
175Aplasia/hypoplasia of the uterus (HP:0008684)1.74892330
176Generalized aminoaciduria (HP:0002909)1.74184891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.65693206
2VRK24.16639012
3WEE13.90443681
4CDK123.34997721
5EIF2AK13.02183496
6SRPK12.70147095
7CDC72.66251637
8NME22.65717760
9TTK2.52749872
10STK162.36047283
11BRSK22.30131953
12WNK32.28502268
13PLK42.25060941
14TNIK2.13194054
15PBK2.12328887
16EIF2AK32.07893482
17ACVR1B2.06930381
18PLK12.05746980
19CDK71.87852594
20TRIM281.87775399
21VRK11.87735006
22TAF11.78944007
23NEK21.76908713
24TLK11.65162659
25GRK51.63787349
26MAP3K121.59480769
27CHEK21.58559320
28ADRBK21.57745362
29MAP4K21.57178088
30MST41.55427263
31MKNK11.52451871
32STK101.52362130
33AURKB1.45000477
34TESK21.44657748
35BMPR1B1.44183946
36EIF2AK21.41415290
37CSF1R1.37107613
38GRK61.35448674
39PIM21.35200534
40BRSK11.32251862
41TSSK61.28423164
42AURKA1.26474786
43MKNK21.25139900
44PNCK1.24918782
45GRK11.21513303
46PLK31.19877527
47DYRK31.19266502
48PDK21.15891726
49INSRR1.12400187
50RPS6KA41.11940945
51EPHA21.11435603
52NEK11.09988565
53ATR1.08186036
54ZAK1.07800942
55CASK1.07177728
56IRAK31.05029602
57PAK41.03938542
58CHEK11.03399986
59GRK71.03384730
60ERN11.01767459
61CSNK1G10.99244641
62CSNK1G20.98209729
63STK40.96628121
64BCR0.92473884
65CSNK1G30.91048895
66CCNB10.90644276
67RPS6KB20.90344636
68OXSR10.89380845
69CDK40.86243316
70MOS0.82877326
71IRAK40.80188171
72MATK0.79887733
73AKT30.78073743
74CDK80.77808787
75NME10.74473106
76FRK0.73144919
77MAP3K80.72898321
78PASK0.72601306
79NUAK10.72205123
80CDK190.72128301
81IKBKB0.71246105
82PLK20.70958565
83CSNK2A10.69698999
84PAK10.69289051
85KDR0.68693979
86TGFBR20.68130014
87ATM0.67199674
88PRKCG0.66207218
89BCKDK0.66116893
90PIM10.65863454
91CDK20.65853667
92CSNK2A20.59843275
93MAP2K70.58922815
94MAPK70.58130026
95MELK0.57016210
96STK390.55409849
97YES10.55281828
98PINK10.55271911
99RPS6KA50.54136352
100PRKCI0.53459464
101BRAF0.52975375
102TGFBR10.51889348
103DYRK20.50550681
104ERBB40.50267429
105CSNK1E0.50030326
106CSNK1A10.49222607
107BLK0.48191367
108CDK10.46794498
109TEC0.44635512
110CLK10.44049130
111TXK0.43451988
112TESK10.43056328
113CSNK1A1L0.42666381
114MAP3K40.41905881
115ERBB30.41747967
116PRKG20.41560712
117CDK30.41259243
118PRKCE0.37993634
119FGFR10.37978296
120ABL20.36945419
121STK38L0.36898607
122DAPK10.36817566
123MAP4K10.36274352
124AKT20.35650338
125MAP3K30.35604536
126STK240.35544793
127TIE10.35498816
128PAK30.30976281
129ADRBK10.30571054
130MAP3K100.30116634
131EPHA40.29783104
132MINK10.28907136
133MYLK0.28758059
134LIMK10.28536851
135LYN0.28381881
136SCYL20.27675156
137ILK0.27340119
138MARK30.25695342
139ALK0.23185149
140STK30.22451489
141PRKCD0.22240097
142MAPKAPK20.21953045

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28832813
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.98469652
3Ribosome_Homo sapiens_hsa030103.95222604
4Proteasome_Homo sapiens_hsa030503.82536129
5Mismatch repair_Homo sapiens_hsa034303.68716151
6RNA polymerase_Homo sapiens_hsa030203.59672791
7Homologous recombination_Homo sapiens_hsa034403.03276445
8Spliceosome_Homo sapiens_hsa030402.95217540
9RNA transport_Homo sapiens_hsa030132.75838172
10Base excision repair_Homo sapiens_hsa034102.57451594
11Nucleotide excision repair_Homo sapiens_hsa034202.55683242
12Pyrimidine metabolism_Homo sapiens_hsa002402.48550093
13Cell cycle_Homo sapiens_hsa041102.29307949
14Fanconi anemia pathway_Homo sapiens_hsa034602.28611120
15Basal transcription factors_Homo sapiens_hsa030222.08584738
16Vitamin B6 metabolism_Homo sapiens_hsa007502.01616569
17One carbon pool by folate_Homo sapiens_hsa006701.92772854
18RNA degradation_Homo sapiens_hsa030181.87449687
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86806462
20Non-homologous end-joining_Homo sapiens_hsa034501.73603367
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71204929
22Protein export_Homo sapiens_hsa030601.62173857
23Cardiac muscle contraction_Homo sapiens_hsa042601.59136934
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58097869
25mRNA surveillance pathway_Homo sapiens_hsa030151.36861536
26p53 signaling pathway_Homo sapiens_hsa041151.31254375
27Purine metabolism_Homo sapiens_hsa002301.30217183
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27871495
29Propanoate metabolism_Homo sapiens_hsa006401.26622659
30Fatty acid elongation_Homo sapiens_hsa000621.25157360
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18040459
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15002861
33Steroid biosynthesis_Homo sapiens_hsa001001.12411244
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08525078
35Epstein-Barr virus infection_Homo sapiens_hsa051691.08306649
36Pyruvate metabolism_Homo sapiens_hsa006201.05868043
37Arachidonic acid metabolism_Homo sapiens_hsa005901.01273033
38Oxidative phosphorylation_Homo sapiens_hsa001901.00483081
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98516545
40Herpes simplex infection_Homo sapiens_hsa051680.97331861
41Parkinsons disease_Homo sapiens_hsa050120.94147221
42Huntingtons disease_Homo sapiens_hsa050160.94060398
43Folate biosynthesis_Homo sapiens_hsa007900.93808955
44Fructose and mannose metabolism_Homo sapiens_hsa000510.89198394
45Sulfur metabolism_Homo sapiens_hsa009200.88869138
46Collecting duct acid secretion_Homo sapiens_hsa049660.84953161
47Butanoate metabolism_Homo sapiens_hsa006500.82895834
48Caffeine metabolism_Homo sapiens_hsa002320.82394071
49Tryptophan metabolism_Homo sapiens_hsa003800.81686543
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79680542
51Antigen processing and presentation_Homo sapiens_hsa046120.79354809
52Systemic lupus erythematosus_Homo sapiens_hsa053220.75687151
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73851073
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.71821730
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70925568
56Legionellosis_Homo sapiens_hsa051340.69178953
57Peroxisome_Homo sapiens_hsa041460.69059365
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67338178
59Phototransduction_Homo sapiens_hsa047440.67234866
60Pentose phosphate pathway_Homo sapiens_hsa000300.67069457
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66632975
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66144870
63Vitamin digestion and absorption_Homo sapiens_hsa049770.64162864
64Viral carcinogenesis_Homo sapiens_hsa052030.63866328
65Graft-versus-host disease_Homo sapiens_hsa053320.62980455
66Galactose metabolism_Homo sapiens_hsa000520.60862469
67Chemical carcinogenesis_Homo sapiens_hsa052040.60597070
68Linoleic acid metabolism_Homo sapiens_hsa005910.60314482
69Sulfur relay system_Homo sapiens_hsa041220.58579022
70Primary immunodeficiency_Homo sapiens_hsa053400.57353216
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56426554
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.56366566
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56120774
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55603267
75Glutathione metabolism_Homo sapiens_hsa004800.55535350
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.55068075
77Allograft rejection_Homo sapiens_hsa053300.54829475
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.53400796
79Regulation of autophagy_Homo sapiens_hsa041400.52470167
80Oocyte meiosis_Homo sapiens_hsa041140.52455320
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51572222
82Hematopoietic cell lineage_Homo sapiens_hsa046400.51501058
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51003607
84Asthma_Homo sapiens_hsa053100.50742274
85Thyroid cancer_Homo sapiens_hsa052160.50465922
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50108050
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49263262
88HTLV-I infection_Homo sapiens_hsa051660.48083587
89Apoptosis_Homo sapiens_hsa042100.47463143
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43802697
91Measles_Homo sapiens_hsa051620.43661468
92Fatty acid degradation_Homo sapiens_hsa000710.42474468
93Retinol metabolism_Homo sapiens_hsa008300.41727058
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41436708
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.41374288
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40948386
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40897605
98Alzheimers disease_Homo sapiens_hsa050100.39660107
99Carbon metabolism_Homo sapiens_hsa012000.39659715
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39452743
101beta-Alanine metabolism_Homo sapiens_hsa004100.38799198
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35136738
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35127209
104Nitrogen metabolism_Homo sapiens_hsa009100.34867039
105Leishmaniasis_Homo sapiens_hsa051400.34541561
106Metabolic pathways_Homo sapiens_hsa011000.34410435
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.34029848
108Mineral absorption_Homo sapiens_hsa049780.33779023
109Autoimmune thyroid disease_Homo sapiens_hsa053200.32887598
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32802377
111Malaria_Homo sapiens_hsa051440.31471679
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31192286
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29384857
114MicroRNAs in cancer_Homo sapiens_hsa052060.29185498
115Other glycan degradation_Homo sapiens_hsa005110.29137245
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29112612
117Arginine and proline metabolism_Homo sapiens_hsa003300.28937847
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28870137
119Fatty acid metabolism_Homo sapiens_hsa012120.26667473
120Fat digestion and absorption_Homo sapiens_hsa049750.26423232
121Ether lipid metabolism_Homo sapiens_hsa005650.25708042
122Influenza A_Homo sapiens_hsa051640.25179372
123TGF-beta signaling pathway_Homo sapiens_hsa043500.22568130
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22133152
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.21247507
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19802806
127Type I diabetes mellitus_Homo sapiens_hsa049400.18939392
128Hepatitis B_Homo sapiens_hsa051610.18927888
129Sphingolipid metabolism_Homo sapiens_hsa006000.18733126
130Pathways in cancer_Homo sapiens_hsa052000.18518589
131Shigellosis_Homo sapiens_hsa051310.17959637
132Small cell lung cancer_Homo sapiens_hsa052220.17472140
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17261185
134Hedgehog signaling pathway_Homo sapiens_hsa043400.16991622
135Biosynthesis of amino acids_Homo sapiens_hsa012300.16075359
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15417477
137N-Glycan biosynthesis_Homo sapiens_hsa005100.14952455
138Alcoholism_Homo sapiens_hsa050340.14298116
139Rheumatoid arthritis_Homo sapiens_hsa053230.13777830
140Selenocompound metabolism_Homo sapiens_hsa004500.13360018
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13272754
142Tyrosine metabolism_Homo sapiens_hsa003500.12947166
143Renin-angiotensin system_Homo sapiens_hsa046140.12751303

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