PAX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.34419112
2Golgi transport vesicle coating (GO:0048200)7.34419112
3endocrine pancreas development (GO:0031018)7.25701456
4negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)6.20676311
5regulation of type B pancreatic cell apoptotic process (GO:2000674)5.94803368
6artery development (GO:0060840)5.83161322
7receptor catabolic process (GO:0032801)5.30429906
8keratinocyte development (GO:0003334)5.28725179
9peptide hormone processing (GO:0016486)5.21534429
10* glandular epithelial cell differentiation (GO:0002067)5.15875258
11positive regulation of insulin secretion (GO:0032024)5.09218774
12type B pancreatic cell development (GO:0003323)5.05810592
13insulin secretion (GO:0030073)4.70327132
14regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.60161943
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.57411790
16embryonic foregut morphogenesis (GO:0048617)4.47805640
17exocrine pancreas development (GO:0031017)4.43895304
18negative regulation of dendrite morphogenesis (GO:0050774)4.37070129
19epithelial cell fate commitment (GO:0072148)4.33225248
20signal peptide processing (GO:0006465)4.32287419
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.31524668
22regulation of insulin secretion (GO:0050796)4.30168454
23gastrulation with mouth forming second (GO:0001702)4.22752578
24protein maturation by protein folding (GO:0022417)4.22318470
25negative regulation of glial cell proliferation (GO:0060253)4.17773116
26COPII vesicle coating (GO:0048208)4.04550719
27histone H3-K9 methylation (GO:0051567)4.01944481
28response to pheromone (GO:0019236)4.01111897
29myelin assembly (GO:0032288)3.99848357
30positive regulation of peptide hormone secretion (GO:0090277)3.99356683
31negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.97215284
32regulation of gene expression by genetic imprinting (GO:0006349)3.95821836
33regulation of peptide hormone secretion (GO:0090276)3.94098906
34protein retention in ER lumen (GO:0006621)3.90876723
35regulation of peptide secretion (GO:0002791)3.86492906
36positive regulation of peptide secretion (GO:0002793)3.86027319
37ER overload response (GO:0006983)3.85394474
38negative regulation of cytosolic calcium ion concentration (GO:0051481)3.81763901
39nitric oxide mediated signal transduction (GO:0007263)3.81568674
40estrogen biosynthetic process (GO:0006703)3.78299982
41negative regulation of dendrite development (GO:2000171)3.78172655
42limb bud formation (GO:0060174)3.76374150
43sequestering of metal ion (GO:0051238)3.75316401
44pre-miRNA processing (GO:0031054)3.72462598
45detection of calcium ion (GO:0005513)3.63797305
46cilium morphogenesis (GO:0060271)3.62075753
47peptide hormone secretion (GO:0030072)3.60958397
48photoreceptor cell maintenance (GO:0045494)3.58485993
49RNA destabilization (GO:0050779)3.56056250
50lymphangiogenesis (GO:0001946)3.54717487
51regulation of hormone secretion (GO:0046883)3.53061992
52genetic imprinting (GO:0071514)3.51495317
53* glandular epithelial cell development (GO:0002068)3.51335430
54peptide secretion (GO:0002790)3.50142847
55cell proliferation in forebrain (GO:0021846)3.49853885
56limb development (GO:0060173)3.48853329
57appendage development (GO:0048736)3.48853329
58positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.42915877
59pancreas development (GO:0031016)3.42346627
60cardiac ventricle formation (GO:0003211)3.40197219
61negative regulation of norepinephrine secretion (GO:0010700)3.34673698
62regulation of glucocorticoid secretion (GO:2000849)3.34505739
63positive regulation of actin filament depolymerization (GO:0030836)3.32802237
64activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.31424714
65cranial nerve development (GO:0021545)3.31319237
66heparan sulfate proteoglycan metabolic process (GO:0030201)3.28487659
67negative regulation of catecholamine secretion (GO:0033604)3.27417541
68mannose metabolic process (GO:0006013)3.25640344
69regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.25327581
70positive regulation of hormone secretion (GO:0046887)3.24847988
71presynaptic membrane assembly (GO:0097105)3.24583945
72pharyngeal system development (GO:0060037)3.23904710
73negative regulation of insulin secretion (GO:0046676)3.22483317
74neuron fate specification (GO:0048665)3.19992401
75intraciliary transport (GO:0042073)3.19926062
76protein targeting to Golgi (GO:0000042)3.19359840
77positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18338812
78glycerophospholipid catabolic process (GO:0046475)3.17708113
79intra-Golgi vesicle-mediated transport (GO:0006891)3.16150310
80heart field specification (GO:0003128)3.14864008
81secondary heart field specification (GO:0003139)3.14864008
82establishment of protein localization to Golgi (GO:0072600)3.14322853
83positive regulation of nuclease activity (GO:0032075)3.14198247
84regulation of peptide transport (GO:0090087)3.12276320
85specification of organ identity (GO:0010092)3.11022951
86cardiac chamber formation (GO:0003207)3.10889160
87macroautophagy (GO:0016236)3.09783816
88substrate-independent telencephalic tangential migration (GO:0021826)3.08534434
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.08534434
90histone H3-K9 modification (GO:0061647)3.06618330
91vesicle coating (GO:0006901)3.06485013
92protein localization to Golgi apparatus (GO:0034067)3.05883790
93intestinal epithelial cell development (GO:0060576)3.04756880
94histone H2A monoubiquitination (GO:0035518)3.04622679
95cellular response to vitamin D (GO:0071305)3.02892781
96positive regulation of neurological system process (GO:0031646)3.02698015
97peptidyl-lysine trimethylation (GO:0018023)3.01608901
98nonmotile primary cilium assembly (GO:0035058)3.01004889
99synapsis (GO:0007129)3.00915992
100postsynaptic membrane organization (GO:0001941)2.98364454
101dentate gyrus development (GO:0021542)2.98294610
102chemosensory behavior (GO:0007635)2.96680999
103GMP metabolic process (GO:0046037)2.95920426
104glial cell proliferation (GO:0014009)2.94910484
105regulation of hexokinase activity (GO:1903299)2.94594483
106regulation of glucokinase activity (GO:0033131)2.94594483
107* columnar/cuboidal epithelial cell development (GO:0002066)2.93539518
108somite development (GO:0061053)2.93099830
109negative regulation of JUN kinase activity (GO:0043508)2.92908566
110hormone secretion (GO:0046879)2.92901584
111cellular response to ATP (GO:0071318)2.92720218
112toxin metabolic process (GO:0009404)2.92023055
113retrograde transport, vesicle recycling within Golgi (GO:0000301)2.90593881
114neuron fate determination (GO:0048664)2.89493441
115inner ear receptor cell development (GO:0060119)2.89457672
116retinal ganglion cell axon guidance (GO:0031290)2.88932944
117regulation of nuclease activity (GO:0032069)2.88464961
118negative regulation of glycoprotein biosynthetic process (GO:0010561)2.86372815
119regulation of autophagic vacuole assembly (GO:2000785)2.86220659
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.86117397
121positive regulation of TOR signaling (GO:0032008)2.85798133
122presynaptic membrane organization (GO:0097090)2.85142365
123spinal cord motor neuron differentiation (GO:0021522)2.83650463
124histone H2A acetylation (GO:0043968)2.83056116
125olfactory bulb development (GO:0021772)2.82812640
126peptide transport (GO:0015833)2.82749611
127negative regulation of peptide hormone secretion (GO:0090278)2.81510071
128nucleoside diphosphate catabolic process (GO:0009134)2.80238055
129magnesium ion transport (GO:0015693)2.79331927
130positive regulation of DNA-templated transcription, initiation (GO:2000144)2.78197894
131prenylation (GO:0097354)2.77778457
132protein prenylation (GO:0018342)2.77778457
133neural tube formation (GO:0001841)2.76623273
134male sex determination (GO:0030238)2.75582114
135oocyte development (GO:0048599)2.75099280
136cellular response to unfolded protein (GO:0034620)2.74601115
137axonal fasciculation (GO:0007413)2.74176233
138cellular response to virus (GO:0098586)2.73879274
139regulation of oligodendrocyte differentiation (GO:0048713)2.73104134
140endoplasmic reticulum unfolded protein response (GO:0030968)2.72701625
141hormone transport (GO:0009914)2.72312296
142regulation of calcium ion-dependent exocytosis (GO:0017158)2.71655433
143cerebellar Purkinje cell layer development (GO:0021680)2.71195108
144regulation of neurotransmitter uptake (GO:0051580)2.70304836
145microtubule anchoring (GO:0034453)2.69683522
146negative regulation of peptide secretion (GO:0002792)2.68760525
147mitochondrion degradation (GO:0000422)2.68589910
148cellular response to topologically incorrect protein (GO:0035967)2.68193004
149histone H2A ubiquitination (GO:0033522)2.68144540
150protein N-linked glycosylation via asparagine (GO:0018279)2.67594536
151dendritic spine morphogenesis (GO:0060997)2.67113747
152ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.66974105
153negative regulation of osteoblast proliferation (GO:0033689)2.66933147
154water-soluble vitamin biosynthetic process (GO:0042364)2.66009742
155regulation of corticosteroid hormone secretion (GO:2000846)2.65760950
156negative regulation of translation, ncRNA-mediated (GO:0040033)2.64329468
157regulation of translation, ncRNA-mediated (GO:0045974)2.64329468
158negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64329468
159peptidyl-asparagine modification (GO:0018196)2.64224730
160* positive regulation of neuroblast proliferation (GO:0002052)2.64208568
161glucose catabolic process (GO:0006007)2.63377821
162* photoreceptor cell development (GO:0042461)2.63365551
163epithelial cilium movement (GO:0003351)2.61785575
164positive regulation of gluconeogenesis (GO:0045722)2.61736671
165response to hepatocyte growth factor (GO:0035728)2.61345561
166cellular response to hepatocyte growth factor stimulus (GO:0035729)2.61345561
167ER-nucleus signaling pathway (GO:0006984)2.60694737
168eye photoreceptor cell differentiation (GO:0001754)2.60658464
169photoreceptor cell differentiation (GO:0046530)2.60658464
170organ growth (GO:0035265)2.60534823
171parental behavior (GO:0060746)2.58972118
172establishment of nucleus localization (GO:0040023)2.58085880
173ear development (GO:0043583)2.58059148
174regulation of cardioblast proliferation (GO:0003264)2.57940100
175regulation of secondary heart field cardioblast proliferation (GO:0003266)2.57940100
176embryonic epithelial tube formation (GO:0001838)2.57704429
177GDP-mannose metabolic process (GO:0019673)2.56459206
178* columnar/cuboidal epithelial cell differentiation (GO:0002065)2.56298515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.05266824
2EZH2_22144423_ChIP-Seq_EOC_Human3.75417866
3DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.89354409
4GBX2_23144817_ChIP-Seq_PC3_Human2.82205402
5IGF1R_20145208_ChIP-Seq_DFB_Human2.64324261
6AHR_22903824_ChIP-Seq_MCF-7_Human2.60748872
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.59341045
8REST_21632747_ChIP-Seq_MESCs_Mouse2.25787987
9ARNT_22903824_ChIP-Seq_MCF-7_Human2.25419157
10TAF15_26573619_Chip-Seq_HEK293_Human2.19373175
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.17165583
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12828686
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10597373
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00947597
15* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99421954
16FUS_26573619_Chip-Seq_HEK293_Human1.98662240
17* EZH2_27294783_Chip-Seq_ESCs_Mouse1.97056845
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.95178087
19* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95043799
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94792630
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90122810
22* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.90080439
23* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.84952255
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84788956
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78537939
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77830082
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77136328
28* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76389082
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75982732
30* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.74510982
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.71609314
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.69875805
33VDR_22108803_ChIP-Seq_LS180_Human1.69730966
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.68997631
35* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68289693
36* EED_16625203_ChIP-ChIP_MESCs_Mouse1.67933232
37* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66878563
38* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63490485
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.63216173
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.61168366
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59978740
42RNF2_27304074_Chip-Seq_NSC_Mouse1.57081505
43HTT_18923047_ChIP-ChIP_STHdh_Human1.53618056
44* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52636260
45CBP_20019798_ChIP-Seq_JUKART_Human1.52017157
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52017157
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50631281
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50571778
49AR_25329375_ChIP-Seq_VCAP_Human1.46878049
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46180062
51* STAT3_23295773_ChIP-Seq_U87_Human1.44821550
52DROSHA_22980978_ChIP-Seq_HELA_Human1.44650290
53* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43991461
54* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41680922
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41492449
56EWS_26573619_Chip-Seq_HEK293_Human1.39552224
57* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38225172
58* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38225172
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.36292679
60* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35103345
61ZNF274_21170338_ChIP-Seq_K562_Hela1.33824168
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33048120
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33048120
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32001660
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31205206
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.30973126
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.30909474
68* SMAD4_21799915_ChIP-Seq_A2780_Human1.30288255
69* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30274119
70* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29851713
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28348123
72ER_23166858_ChIP-Seq_MCF-7_Human1.27868075
73* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27564089
74GATA1_22025678_ChIP-Seq_K562_Human1.27442885
75TP53_22573176_ChIP-Seq_HFKS_Human1.25254093
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23430329
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22961445
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.22929435
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22451812
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22398139
81P300_19829295_ChIP-Seq_ESCs_Human1.21365534
82* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21120916
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20680345
84* STAT3_18555785_Chip-Seq_ESCs_Mouse1.20219110
85* NMYC_18555785_Chip-Seq_ESCs_Mouse1.19760833
86* P53_22387025_ChIP-Seq_ESCs_Mouse1.19517214
87AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18171842
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18153405
89TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18036049
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17081049
91TCF4_23295773_ChIP-Seq_U87_Human1.16443442
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16394288
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15430090
94MYC_18940864_ChIP-ChIP_HL60_Human1.13792386
95RUNX2_22187159_ChIP-Seq_PCA_Human1.13359719
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12802229
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12494681
98RXR_22108803_ChIP-Seq_LS180_Human1.12433537
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12214909
100* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11573697
101TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11510584
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10815751
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10727039
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09673672
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09114320
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09102498
107BCAT_22108803_ChIP-Seq_LS180_Human1.08398775
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08209092
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08208174
110PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08076568
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07879771
112REST_19997604_ChIP-ChIP_NEURONS_Mouse1.06591168
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06263579
114* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05780862
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05697477
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05331731
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04634112
118* RING1B_27294783_Chip-Seq_ESCs_Mouse1.03941666
119* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03855314
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03441393
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02383817
122* TBL1_22424771_ChIP-Seq_293T_Human1.02068454
123* SMAD3_21741376_ChIP-Seq_EPCs_Human1.01746655
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01369295
125* AR_19668381_ChIP-Seq_PC3_Human1.00891917
126SMAD3_21741376_ChIP-Seq_ESCs_Human1.00463951
127* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99266855
128* CMYC_18555785_Chip-Seq_ESCs_Mouse0.98973503
129* E2F1_18555785_Chip-Seq_ESCs_Mouse0.98963816
130* RING1B_27294783_Chip-Seq_NPCs_Mouse0.98264306
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.97373527
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.96979424
133GF1B_26923725_Chip-Seq_HPCs_Mouse0.95869662
134* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95048807
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94688019
136* P300_18555785_Chip-Seq_ESCs_Mouse0.93410495
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93220234
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92575065
139* ZFX_18555785_Chip-Seq_ESCs_Mouse0.90734364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.38972771
2MP0006072_abnormal_retinal_apoptosis3.88627187
3MP0002877_abnormal_melanocyte_morpholog3.86496381
4MP0003283_abnormal_digestive_organ3.75559137
5* MP0002693_abnormal_pancreas_physiology3.45917744
6* MP0001944_abnormal_pancreas_morphology3.39800920
7MP0000678_abnormal_parathyroid_gland3.37403581
8MP0004043_abnormal_pH_regulation3.37032027
9MP0005379_endocrine/exocrine_gland_phen3.26430899
10MP0009780_abnormal_chondrocyte_physiolo3.16074649
11MP0002909_abnormal_adrenal_gland3.11709654
12MP0003183_abnormal_peptide_metabolism3.09481252
13MP0000013_abnormal_adipose_tissue3.09151691
14MP0010386_abnormal_urinary_bladder2.86619372
15MP0005220_abnormal_exocrine_pancreas2.68003260
16MP0003195_calcinosis2.62959992
17MP0005645_abnormal_hypothalamus_physiol2.59213234
18MP0002160_abnormal_reproductive_system2.59141770
19MP0005646_abnormal_pituitary_gland2.59057970
20MP0001986_abnormal_taste_sensitivity2.53926352
21MP0005253_abnormal_eye_physiology2.52173755
22MP0009046_muscle_twitch2.44752878
23MP0000631_abnormal_neuroendocrine_gland2.15996553
24MP0000383_abnormal_hair_follicle2.13049201
25MP0005551_abnormal_eye_electrophysiolog2.12409759
26MP0008057_abnormal_DNA_replication2.11937941
27MP0010678_abnormal_skin_adnexa2.09260021
28MP0010234_abnormal_vibrissa_follicle1.92077787
29MP0002102_abnormal_ear_morphology1.84745623
30MP0004133_heterotaxia1.84684564
31MP0001502_abnormal_circadian_rhythm1.80891237
32MP0001919_abnormal_reproductive_system1.79254807
33* MP0002078_abnormal_glucose_homeostasis1.71826050
34MP0002928_abnormal_bile_duct1.70528609
35MP0002234_abnormal_pharynx_morphology1.66960705
36MP0005389_reproductive_system_phenotype1.60423711
37MP0003122_maternal_imprinting1.60170381
38MP0004270_analgesia1.57726887
39MP0002837_dystrophic_cardiac_calcinosis1.54034618
40MP0000003_abnormal_adipose_tissue1.52262565
41MP0001188_hyperpigmentation1.50793103
42MP0002163_abnormal_gland_morphology1.50419302
43MP0003136_yellow_coat_color1.47959357
44* MP0002938_white_spotting1.47922287
45MP0003787_abnormal_imprinting1.45991223
46MP0001984_abnormal_olfaction1.41526298
47MP0002751_abnormal_autonomic_nervous1.39845922
48* MP0006292_abnormal_olfactory_placode1.37724062
49MP0001270_distended_abdomen1.32950835
50* MP0002638_abnormal_pupillary_reflex1.31852393
51MP0000049_abnormal_middle_ear1.30733864
52MP0009745_abnormal_behavioral_response1.30644074
53MP0003890_abnormal_embryonic-extraembry1.29421155
54MP0005410_abnormal_fertilization1.27157844
55MP0000462_abnormal_digestive_system1.26414590
56MP0002896_abnormal_bone_mineralization1.23985833
57MP0003119_abnormal_digestive_system1.22631073
58MP0002557_abnormal_social/conspecific_i1.18707602
59MP0003880_abnormal_central_pattern1.17750607
60MP0003938_abnormal_ear_development1.17383097
61MP0002064_seizures1.16063146
62MP0002653_abnormal_ependyma_morphology1.15685739
63MP0000681_abnormal_thyroid_gland1.14611463
64MP0003937_abnormal_limbs/digits/tail_de1.14329679
65* MP0005391_vision/eye_phenotype1.13696077
66* MP0003953_abnormal_hormone_level1.13101696
67MP0002734_abnormal_mechanical_nocicepti1.12244364
68MP0002184_abnormal_innervation1.10655393
69MP0003868_abnormal_feces_composition1.07981974
70MP0001765_abnormal_ion_homeostasis1.05727008
71MP0000566_synostosis1.05015839
72MP0002009_preneoplasia1.02661357
73MP0002233_abnormal_nose_morphology1.02410858
74MP0004264_abnormal_extraembryonic_tissu1.02174419
75MP0004885_abnormal_endolymph1.00361026
76MP0002063_abnormal_learning/memory/cond0.98902133
77MP0001501_abnormal_sleep_pattern0.98861957
78MP0002876_abnormal_thyroid_physiology0.98481689
79* MP0002177_abnormal_outer_ear0.98339958
80MP0002229_neurodegeneration0.97565265
81MP0003879_abnormal_hair_cell0.97280200
82MP0003011_delayed_dark_adaptation0.97159876
83MP0003959_abnormal_lean_body0.96788609
84MP0003941_abnormal_skin_development0.94198793
85MP0005248_abnormal_Harderian_gland0.93963363
86MP0004924_abnormal_behavior0.93826613
87MP0005386_behavior/neurological_phenoty0.93826613
88* MP0008789_abnormal_olfactory_epithelium0.92697756
89MP0008961_abnormal_basal_metabolism0.91857313
90* MP0000428_abnormal_craniofacial_morphol0.90870601
91MP0005187_abnormal_penis_morphology0.88581628
92* MP0000613_abnormal_salivary_gland0.88051488
93MP0002272_abnormal_nervous_system0.87761690
94MP0002735_abnormal_chemical_nociception0.86419131
95MP0005448_abnormal_energy_balance0.85528256
96* MP0005195_abnormal_posterior_eye0.85474389
97MP0003123_paternal_imprinting0.85355396
98MP0003172_abnormal_lysosome_physiology0.84714670
99MP0003633_abnormal_nervous_system0.84634507
100MP0003137_abnormal_impulse_conducting0.84208800
101MP0001293_anophthalmia0.84163077
102MP0006276_abnormal_autonomic_nervous0.83699824
103MP0009053_abnormal_anal_canal0.82485211
104MP0000647_abnormal_sebaceous_gland0.82479148
105MP0001968_abnormal_touch/_nociception0.82291537
106* MP0002882_abnormal_neuron_morphology0.82108583
107* MP0005394_taste/olfaction_phenotype0.80983844
108* MP0005499_abnormal_olfactory_system0.80983844
109MP0002822_catalepsy0.80769130
110MP0004145_abnormal_muscle_electrophysio0.79146446
111MP0000026_abnormal_inner_ear0.78647078
112MP0000015_abnormal_ear_pigmentation0.78448797
113MP0005367_renal/urinary_system_phenotyp0.77908354
114MP0000516_abnormal_urinary_system0.77908354
115MP0001299_abnormal_eye_distance/0.77487554
116MP0008569_lethality_at_weaning0.77398864
117MP0005409_darkened_coat_color0.77022018
118MP0004859_abnormal_synaptic_plasticity0.77021295
119MP0001346_abnormal_lacrimal_gland0.76237346
120MP0002733_abnormal_thermal_nociception0.75269644
121* MP0000955_abnormal_spinal_cord0.74502553
122MP0001485_abnormal_pinna_reflex0.74174551
123MP0002069_abnormal_eating/drinking_beha0.74054383
124MP0002067_abnormal_sensory_capabilities0.73770936
125MP0001970_abnormal_pain_threshold0.73283226
126MP0005423_abnormal_somatic_nervous0.72631959
127* MP0000778_abnormal_nervous_system0.71809941
128MP0000538_abnormal_urinary_bladder0.71127808
129* MP0001324_abnormal_eye_pigmentation0.71109112
130MP0002090_abnormal_vision0.71108736
131MP0002572_abnormal_emotion/affect_behav0.70676089
132MP0003635_abnormal_synaptic_transmissio0.70257790
133MP0005310_abnormal_salivary_gland0.70092074
134* MP0002752_abnormal_somatic_nervous0.69344293
135MP0001486_abnormal_startle_reflex0.68032660
136* MP0003755_abnormal_palate_morphology0.66971047
137MP0003121_genomic_imprinting0.66239019
138MP0005535_abnormal_body_temperature0.66056947
139* MP0002116_abnormal_craniofacial_bone0.65287782
140MP0002277_abnormal_respiratory_mucosa0.64884326
141MP0004742_abnormal_vestibular_system0.64792340
142MP0001664_abnormal_digestion0.64156995
143MP0005084_abnormal_gallbladder_morpholo0.62397592
144MP0009672_abnormal_birth_weight0.59839843

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.86995051
2Hypoglycemic seizures (HP:0002173)6.56370419
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.17702642
4Symptomatic seizures (HP:0011145)6.15133666
5Difficulty running (HP:0009046)6.06204531
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.91904924
7Hyperglycemia (HP:0003074)4.77640730
8Abnormality of the aortic arch (HP:0012303)4.73867047
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.59851446
10Hypoglycemic coma (HP:0001325)4.59092499
11Insulin-resistant diabetes mellitus (HP:0000831)4.58753175
12Osteomalacia (HP:0002749)4.11772095
13Abnormal rod and cone electroretinograms (HP:0008323)3.97050608
14Abnormality of endocrine pancreas physiology (HP:0012093)3.91638549
15Abnormality of the pancreatic islet cells (HP:0006476)3.91638549
16Pancreatic islet-cell hyperplasia (HP:0004510)3.87141097
17Large for gestational age (HP:0001520)3.78037853
18Hip dysplasia (HP:0001385)3.76112022
19Decreased circulating renin level (HP:0003351)3.73059986
20Hip contracture (HP:0003273)3.71340162
21Agitation (HP:0000713)3.70301892
22Aqueductal stenosis (HP:0002410)3.47471272
23Abnormal pancreas size (HP:0012094)3.41013490
24Late onset (HP:0003584)3.36313551
25Intestinal atresia (HP:0011100)3.30522438
26Ketoacidosis (HP:0001993)3.14903641
27Bony spicule pigmentary retinopathy (HP:0007737)3.09264702
28Congenital malformation of the right heart (HP:0011723)3.07824802
29Double outlet right ventricle (HP:0001719)3.07824802
30Abnormality of the metopic suture (HP:0005556)3.04563037
31Prominent metopic ridge (HP:0005487)3.02554701
32Hypokalemia (HP:0002900)2.99561058
33Hyperparathyroidism (HP:0000843)2.93294760
34Oligodactyly (hands) (HP:0001180)2.91302213
35Limb dystonia (HP:0002451)2.89727323
36Biliary tract neoplasm (HP:0100574)2.88809563
37Congenital stationary night blindness (HP:0007642)2.84881270
38Retinal atrophy (HP:0001105)2.83867410
39Limited hip movement (HP:0008800)2.75765622
40Attenuation of retinal blood vessels (HP:0007843)2.73829429
41Decreased central vision (HP:0007663)2.73706362
42Type II diabetes mellitus (HP:0005978)2.71441951
43Severe visual impairment (HP:0001141)2.71205561
44Unilateral renal agenesis (HP:0000122)2.66296747
45Congenital sensorineural hearing impairment (HP:0008527)2.65406569
46Hypothermia (HP:0002045)2.64327295
47Neoplasm of the adrenal cortex (HP:0100641)2.62286173
48Type I transferrin isoform profile (HP:0003642)2.60170610
49Oligodactyly (HP:0012165)2.56805072
50Abnormality of renin-angiotensin system (HP:0000847)2.56199764
51Nephronophthisis (HP:0000090)2.51954471
52Hyperventilation (HP:0002883)2.49509234
53Achilles tendon contracture (HP:0001771)2.46605547
54Pendular nystagmus (HP:0012043)2.44311540
55Abnormality of potassium homeostasis (HP:0011042)2.44204064
56Abnormal protein glycosylation (HP:0012346)2.43090713
57Abnormal glycosylation (HP:0012345)2.43090713
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43090713
59Abnormal protein N-linked glycosylation (HP:0012347)2.43090713
60Insulin resistance (HP:0000855)2.42632334
61Hyperphosphatemia (HP:0002905)2.39352283
62True hermaphroditism (HP:0010459)2.37704096
63EEG with generalized epileptiform discharges (HP:0011198)2.36659978
64Gait imbalance (HP:0002141)2.35198204
65Abnormality of the Achilles tendon (HP:0005109)2.34473675
66Gastrointestinal atresia (HP:0002589)2.33913404
67Hypsarrhythmia (HP:0002521)2.32952015
68Broad-based gait (HP:0002136)2.30487039
69Conjugated hyperbilirubinemia (HP:0002908)2.29282059
70Mucopolysacchariduria (HP:0008155)2.28910283
71Urinary glycosaminoglycan excretion (HP:0003541)2.28910283
72Hemiparesis (HP:0001269)2.28093879
73Epileptiform EEG discharges (HP:0011182)2.27062589
74Cystic liver disease (HP:0006706)2.25876961
75Abnormality of the labia minora (HP:0012880)2.25287868
76Adrenal hypoplasia (HP:0000835)2.23883805
77Thyroiditis (HP:0100646)2.23358222
78Restlessness (HP:0000711)2.22789125
79Hyperkalemia (HP:0002153)2.21743963
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20773684
81Abnormality of polysaccharide metabolism (HP:0011012)2.20773684
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20773684
83Pancreatic fibrosis (HP:0100732)2.20240463
84Tetraplegia (HP:0002445)2.19932256
85Abnormality of the renal cortex (HP:0011035)2.19048820
86Methylmalonic acidemia (HP:0002912)2.17674959
87Enlarged penis (HP:0000040)2.16359956
88Central scotoma (HP:0000603)2.14566654
89Hyperactive renin-angiotensin system (HP:0000841)2.13204209
90Pancreatic cysts (HP:0001737)2.12829720
91Exocrine pancreatic insufficiency (HP:0001738)2.12798531
92Congenital primary aphakia (HP:0007707)2.09777628
93Cortical visual impairment (HP:0100704)2.06068045
94Growth hormone deficiency (HP:0000824)2.05626523
95Abolished electroretinogram (ERG) (HP:0000550)2.05319905
96Abnormality of macular pigmentation (HP:0008002)2.04290640
97Esophageal atresia (HP:0002032)2.03290942
98Anophthalmia (HP:0000528)2.01395403
99Abnormality of cochlea (HP:0000375)2.01380767
100Aplasia/hypoplasia of the uterus (HP:0008684)2.00712700
101Dysostosis multiplex (HP:0000943)2.00691321
102Constricted visual fields (HP:0001133)2.00367082
103Abnormality of the renal medulla (HP:0100957)1.98329810
104* Hypoplasia of the fovea (HP:0007750)1.96465545
105* Aplasia/Hypoplasia of the fovea (HP:0008060)1.96465545
106Large eyes (HP:0001090)1.95473494
107Dysautonomia (HP:0002459)1.94834951
108Abnormal biliary tract morphology (HP:0012440)1.94674177
109Generalized aminoaciduria (HP:0002909)1.94179497
110Anteriorly placed anus (HP:0001545)1.92644077
111Absent eyebrow (HP:0002223)1.91708911
112Rhabdomyosarcoma (HP:0002859)1.90858220
113Septo-optic dysplasia (HP:0100842)1.89901632
114Atrioventricular canal defect (HP:0006695)1.88923159
115Renal cortical cysts (HP:0000803)1.88040172
116Increased CSF protein (HP:0002922)1.86953052
117Hypomagnesemia (HP:0002917)1.86262400
118Retinitis pigmentosa (HP:0000510)1.85750905
119Menstrual irregularities (HP:0000858)1.85542833
120Split foot (HP:0001839)1.84749642
121Abnormality of vitamin B metabolism (HP:0004340)1.84203127
122Hypercortisolism (HP:0001578)1.83339472
123Abnormality of midbrain morphology (HP:0002418)1.83036683
124Molar tooth sign on MRI (HP:0002419)1.83036683
125Nephrogenic diabetes insipidus (HP:0009806)1.82744558
126Abnormal drinking behavior (HP:0030082)1.81875056
127Polydipsia (HP:0001959)1.81875056
128Status epilepticus (HP:0002133)1.81513061
129Abnormal sex determination (HP:0012244)1.80758559
130Sex reversal (HP:0012245)1.80758559
131Visual hallucinations (HP:0002367)1.79866132
132Diastasis recti (HP:0001540)1.78508498
133Adrenal overactivity (HP:0002717)1.77782281
134Labial hypoplasia (HP:0000066)1.75598969
135Chronic hepatic failure (HP:0100626)1.75458048
136Ketosis (HP:0001946)1.75197466
137Abnormality of chloride homeostasis (HP:0011422)1.73989077
138Photophobia (HP:0000613)1.73672903
139Thyroid carcinoma (HP:0002890)1.72850706
140Hyperaldosteronism (HP:0000859)1.72225090
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71788827
142Short 4th metacarpal (HP:0010044)1.71788827
143Bifid tongue (HP:0010297)1.70756592
144Overlapping toe (HP:0001845)1.69509664
145Poor coordination (HP:0002370)1.69252900
146Progressive neurologic deterioration (HP:0002344)1.68999803
147Posterior subcapsular cataract (HP:0007787)1.68202024
148Progressive cerebellar ataxia (HP:0002073)1.68091292
149Medial flaring of the eyebrow (HP:0010747)1.67797805
150Renal dysplasia (HP:0000110)1.67786397
151Enlarged kidneys (HP:0000105)1.67627270
152Genital tract atresia (HP:0001827)1.66422758
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.66294851
154Abnormality of the parathyroid morphology (HP:0011766)1.66251869
155Hypophosphatemia (HP:0002148)1.65957871
156Hepatoblastoma (HP:0002884)1.65646726
157Type II lissencephaly (HP:0007260)1.65400009
158Median cleft lip (HP:0000161)1.63014491
159Atelectasis (HP:0100750)1.61899664
160Papillary thyroid carcinoma (HP:0002895)1.60549617
161Scotoma (HP:0000575)1.59837670
162Abnormality of magnesium homeostasis (HP:0004921)1.58491289
163Abdominal distention (HP:0003270)1.58331798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.19471017
2PTK2B4.98917686
3MAPK154.93501382
4PASK4.32045926
5WNK33.27592972
6TAOK32.99193148
7TNIK2.46032047
8WEE12.44617319
9FGFR22.30763619
10UHMK12.21377443
11CASK2.05720668
12* HIPK22.03603232
13PRKD31.96735830
14BRSK21.91291505
15MAP3K21.84352317
16IRAK21.78207755
17MAP3K41.76929963
18DYRK1B1.69752850
19IRAK31.69561206
20FRK1.68872937
21MAP4K21.64978050
22IRAK11.63255809
23NTRK31.62393176
24WNK41.54553733
25PRKD21.45907150
26STK161.40094264
27PHKG11.38116703
28PHKG21.38116703
29PIK3CG1.36082846
30CAMKK21.34048159
31CDC42BPA1.33243949
32MKNK21.31084532
33ACVR1B1.27088791
34EIF2AK31.26104817
35STK31.26086922
36STK241.23300246
37NLK1.20678277
38PAK61.20444497
39AKT31.18037675
40CSNK1G11.13494962
41MAP3K11.05701213
42RPS6KB21.05672269
43DYRK31.05326156
44PLK21.05029156
45EPHA31.04039207
46BMPR1B1.00665541
47BRD40.98735172
48CSNK1G30.95367343
49NEK60.95198907
50PRKCG0.94154710
51SIK30.92911150
52CDK190.91265540
53IRAK40.90673495
54SGK20.89988478
55DYRK1A0.88938157
56MAP3K90.88814902
57GRK10.87739215
58SGK4940.86702184
59SGK2230.86702184
60CSNK1G20.85420133
61VRK10.84928829
62NUAK10.83494719
63WNK10.82245492
64EPHA40.79962883
65OXSR10.79374580
66FLT30.76620954
67YES10.76571597
68PRKCH0.76266287
69MAPK130.76069985
70CDK30.75371301
71DAPK20.75255442
72MAPK70.73723731
73STK110.72514791
74TLK10.72428326
75SRPK10.72061921
76KSR20.71016638
77VRK20.69638625
78ERBB30.68435386
79DYRK20.68008060
80ADRBK20.67735402
81TYRO30.66513947
82BRSK10.66316450
83PIK3CA0.65842354
84PNCK0.64939962
85MAP2K20.64623853
86PAK30.64073215
87PRKCE0.63949515
88ZAK0.62896851
89SIK10.62113037
90MAP2K70.62105760
91BCR0.62013097
92PTK60.59098047
93PRKAA10.59073695
94BCKDK0.57784607
95MARK10.57640945
96PTK20.56832224
97TEC0.55644439
98FER0.54304321
99MUSK0.54281985
100KSR10.53348645
101MARK20.52718452
102BMPR20.51061628
103NTRK10.49770565
104PINK10.48826275
105PDGFRA0.48590638
106MAP2K10.48343002
107STK390.47960324
108CSNK1D0.47244821
109TAOK10.45780428
110EPHB20.45577054
111CSNK1A10.44999952
112LATS10.44492733
113CAMK2D0.44491879
114PRKCZ0.42713923
115PRKDC0.42126031
116RPS6KA20.40356559
117CSNK1A1L0.39818893
118NTRK20.39781820
119MAPK140.39354270
120RAF10.38840353
121RPS6KB10.38659616
122SGK10.38108295
123PRKACA0.38028595
124ITK0.37285774
125PKN10.37127136
126TRPM70.37040827
127PRKCI0.36424007
128CAMK2B0.36096696
129PRKG10.35435035
130GSK3A0.34201166
131PRKAA20.33709459
132AKT10.33608412
133CAMK1G0.33088512
134BRAF0.32424627
135CHUK0.32310861
136MAP2K40.32147395
137GSK3B0.31850980
138SGK30.31233074
139PLK30.30459156
140PRKD10.30300025
141ADRBK10.30204989
142ERN10.29584656
143STK38L0.29331316
144ERBB20.29286325
145MAP2K60.28898921
146CDK50.28488181
147CSNK1E0.27139588

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049508.47597706
2Protein export_Homo sapiens_hsa030604.93104578
3Vitamin B6 metabolism_Homo sapiens_hsa007503.74889826
4Insulin secretion_Homo sapiens_hsa049113.34010996
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.56676731
6Phototransduction_Homo sapiens_hsa047442.47962140
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.41340416
8Sulfur metabolism_Homo sapiens_hsa009202.33925207
9Type II diabetes mellitus_Homo sapiens_hsa049302.23381859
10Type I diabetes mellitus_Homo sapiens_hsa049402.16874056
11Steroid biosynthesis_Homo sapiens_hsa001002.14230044
12Butanoate metabolism_Homo sapiens_hsa006502.08754375
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88461399
14N-Glycan biosynthesis_Homo sapiens_hsa005101.78120471
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.70335435
16Circadian rhythm_Homo sapiens_hsa047101.68994529
17Taste transduction_Homo sapiens_hsa047421.67812625
18Pentose phosphate pathway_Homo sapiens_hsa000301.66059590
19Cocaine addiction_Homo sapiens_hsa050301.63374053
20Vibrio cholerae infection_Homo sapiens_hsa051101.58889770
21Fanconi anemia pathway_Homo sapiens_hsa034601.57441250
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52899608
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36712390
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.36281553
25Amphetamine addiction_Homo sapiens_hsa050311.27182629
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25879445
27GABAergic synapse_Homo sapiens_hsa047271.25313378
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22117444
29Pancreatic secretion_Homo sapiens_hsa049721.22065271
30Serotonergic synapse_Homo sapiens_hsa047261.21567993
31Circadian entrainment_Homo sapiens_hsa047131.14982635
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13763654
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.12505603
34Tryptophan metabolism_Homo sapiens_hsa003801.10603468
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10046023
36Selenocompound metabolism_Homo sapiens_hsa004501.06127356
37Other glycan degradation_Homo sapiens_hsa005111.04081719
38Morphine addiction_Homo sapiens_hsa050321.03672886
39Cholinergic synapse_Homo sapiens_hsa047251.03374594
40Dopaminergic synapse_Homo sapiens_hsa047281.03211509
41Regulation of autophagy_Homo sapiens_hsa041401.01799291
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99341765
43Synaptic vesicle cycle_Homo sapiens_hsa047210.97626882
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94905954
45Sphingolipid metabolism_Homo sapiens_hsa006000.94868261
46Lysosome_Homo sapiens_hsa041420.94572153
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93009398
48ABC transporters_Homo sapiens_hsa020100.92778936
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92029141
50Nitrogen metabolism_Homo sapiens_hsa009100.90559917
51Glutamatergic synapse_Homo sapiens_hsa047240.90534027
52Alcoholism_Homo sapiens_hsa050340.87821156
53* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87750736
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82614782
55Propanoate metabolism_Homo sapiens_hsa006400.80599694
56Thyroid hormone synthesis_Homo sapiens_hsa049180.78988560
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77531450
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76353129
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76212617
60Oxidative phosphorylation_Homo sapiens_hsa001900.76032549
61Cardiac muscle contraction_Homo sapiens_hsa042600.75668134
62Glucagon signaling pathway_Homo sapiens_hsa049220.75531111
63mTOR signaling pathway_Homo sapiens_hsa041500.75290787
64Long-term potentiation_Homo sapiens_hsa047200.74961275
65RNA degradation_Homo sapiens_hsa030180.74427873
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73752350
67Oocyte meiosis_Homo sapiens_hsa041140.72873389
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71160510
69Prolactin signaling pathway_Homo sapiens_hsa049170.71051353
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70980761
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70976745
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70879145
73Nicotine addiction_Homo sapiens_hsa050330.67924105
74Hippo signaling pathway_Homo sapiens_hsa043900.67291314
75cAMP signaling pathway_Homo sapiens_hsa040240.66215355
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65970574
77Inositol phosphate metabolism_Homo sapiens_hsa005620.65304038
78TGF-beta signaling pathway_Homo sapiens_hsa043500.65281124
79Linoleic acid metabolism_Homo sapiens_hsa005910.65215377
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.65047014
81Caffeine metabolism_Homo sapiens_hsa002320.64208026
82Bile secretion_Homo sapiens_hsa049760.63740866
83Folate biosynthesis_Homo sapiens_hsa007900.63026534
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61107143
85Mineral absorption_Homo sapiens_hsa049780.60219108
86Wnt signaling pathway_Homo sapiens_hsa043100.59599088
87Insulin resistance_Homo sapiens_hsa049310.58948269
88Retinol metabolism_Homo sapiens_hsa008300.56601457
89Vitamin digestion and absorption_Homo sapiens_hsa049770.56276608
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55993671
91Peroxisome_Homo sapiens_hsa041460.53122941
92Renin secretion_Homo sapiens_hsa049240.51694087
93Long-term depression_Homo sapiens_hsa047300.51310995
94Prion diseases_Homo sapiens_hsa050200.50009268
95Melanogenesis_Homo sapiens_hsa049160.49859123
96beta-Alanine metabolism_Homo sapiens_hsa004100.49839687
97Glycerolipid metabolism_Homo sapiens_hsa005610.47761527
98Prostate cancer_Homo sapiens_hsa052150.47404476
99Estrogen signaling pathway_Homo sapiens_hsa049150.47368232
100Collecting duct acid secretion_Homo sapiens_hsa049660.46582279
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45694657
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45320962
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.45138784
104Metabolic pathways_Homo sapiens_hsa011000.45010463
105Lysine degradation_Homo sapiens_hsa003100.43853664
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42035931
107Endometrial cancer_Homo sapiens_hsa052130.40400530
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39984350
109Fatty acid elongation_Homo sapiens_hsa000620.39793029
110Oxytocin signaling pathway_Homo sapiens_hsa049210.39755302
111Ether lipid metabolism_Homo sapiens_hsa005650.38416219
112Gastric acid secretion_Homo sapiens_hsa049710.38123235
113Thyroid cancer_Homo sapiens_hsa052160.37192710
114Hedgehog signaling pathway_Homo sapiens_hsa043400.37185417
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36882025
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36661628
117Olfactory transduction_Homo sapiens_hsa047400.36641664
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34815306
119Galactose metabolism_Homo sapiens_hsa000520.34342376
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34061442
121Notch signaling pathway_Homo sapiens_hsa043300.32203607
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30505894
123Insulin signaling pathway_Homo sapiens_hsa049100.28936831
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28443219
125Ovarian steroidogenesis_Homo sapiens_hsa049130.27544745
126Basal cell carcinoma_Homo sapiens_hsa052170.27117947
127Protein digestion and absorption_Homo sapiens_hsa049740.27058406
128Basal transcription factors_Homo sapiens_hsa030220.26331756
129FoxO signaling pathway_Homo sapiens_hsa040680.22734992
130Gap junction_Homo sapiens_hsa045400.22723127
131Salivary secretion_Homo sapiens_hsa049700.22650326
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22149311
133Calcium signaling pathway_Homo sapiens_hsa040200.21078073
134Arachidonic acid metabolism_Homo sapiens_hsa005900.19853508
135Starch and sucrose metabolism_Homo sapiens_hsa005000.19825000
136Dorso-ventral axis formation_Homo sapiens_hsa043200.19664273
137mRNA surveillance pathway_Homo sapiens_hsa030150.19100626
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18359936
139Axon guidance_Homo sapiens_hsa043600.17828558
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16169016

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