PATE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of clathrin-mediated endocytosis (GO:2000369)7.83197204
2positive regulation of antigen processing and presentation (GO:0002579)7.34743693
3urinary tract smooth muscle contraction (GO:0014848)6.60149721
4regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033396.38832457
5regulation of hydrogen peroxide metabolic process (GO:0010310)6.34951994
6pharyngeal system development (GO:0060037)6.24275424
7regulation of acrosome reaction (GO:0060046)6.20942150
8reproduction (GO:0000003)6.05421302
9collecting duct development (GO:0072044)5.84248038
10regulation of antigen processing and presentation (GO:0002577)5.74722261
11fusion of sperm to egg plasma membrane (GO:0007342)5.72267355
12cell proliferation in forebrain (GO:0021846)5.52427058
13prostanoid metabolic process (GO:0006692)5.49454024
14prostaglandin metabolic process (GO:0006693)5.49454024
15mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.43538195
16negative regulation of receptor-mediated endocytosis (GO:0048261)5.21335050
17regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.17476616
18spinal cord association neuron differentiation (GO:0021527)5.09789779
19endocrine hormone secretion (GO:0060986)5.08816056
20complement activation, alternative pathway (GO:0006957)5.07578333
21positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.03071472
22regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.03071472
23maintenance of gastrointestinal epithelium (GO:0030277)4.81195289
24response to lipoprotein particle (GO:0055094)4.79323033
25pattern specification involved in kidney development (GO:0061004)4.77470573
26urogenital system development (GO:0001655)4.75293368
27cerebellar Purkinje cell differentiation (GO:0021702)4.65430668
28positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.60407805
29regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.60407805
30positive regulation of metanephros development (GO:0072216)4.48938275
31interkinetic nuclear migration (GO:0022027)4.38684711
32histone H4-K12 acetylation (GO:0043983)4.37423996
33musculoskeletal movement (GO:0050881)4.35174028
34multicellular organismal movement (GO:0050879)4.35174028
35peristalsis (GO:0030432)4.34379880
36serotonin metabolic process (GO:0042428)4.33231674
37plasma membrane fusion (GO:0045026)4.32072686
38cytoplasmic mRNA processing body assembly (GO:0033962)4.28635737
39negative regulation of translation, ncRNA-mediated (GO:0040033)4.18343056
40regulation of translation, ncRNA-mediated (GO:0045974)4.18343056
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.18343056
42regulation of short-term neuronal synaptic plasticity (GO:0048172)4.17075165
43metanephric nephron epithelium development (GO:0072243)4.13348796
44regulation of Cdc42 GTPase activity (GO:0043088)4.08447260
45regulation of bile acid biosynthetic process (GO:0070857)4.02377110
46regulation of activation of Janus kinase activity (GO:0010533)3.96471095
47macroautophagy (GO:0016236)3.90580877
48regulation of apoptotic process involved in morphogenesis (GO:1902337)3.85708549
49negative regulation of sodium ion transport (GO:0010766)3.83939625
50positive regulation of mRNA catabolic process (GO:0061014)3.78367528
51metanephric epithelium development (GO:0072207)3.78082501
52respiratory burst (GO:0045730)3.72060140
53negative regulation of protein localization to cell surface (GO:2000009)3.69043199
54sulfur amino acid catabolic process (GO:0000098)3.63438871
55locomotory exploration behavior (GO:0035641)3.63196537
56epithelial structure maintenance (GO:0010669)3.55043073
57GPI anchor biosynthetic process (GO:0006506)3.50755365
58regulation of hippo signaling (GO:0035330)3.50065677
59primary amino compound metabolic process (GO:1901160)3.49939639
60opioid receptor signaling pathway (GO:0038003)3.48635454
61regulation of respiratory burst (GO:0060263)3.47392848
62negative regulation of transcription by competitive promoter binding (GO:0010944)3.46707803
63GPI anchor metabolic process (GO:0006505)3.44940226
64regulation of acyl-CoA biosynthetic process (GO:0050812)3.40044890
65phosphatidylinositol acyl-chain remodeling (GO:0036149)3.39123870
66brown fat cell differentiation (GO:0050873)3.35071824
67ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.32472146
68cardiovascular system development (GO:0072358)3.30451784
69negative regulation of endopeptidase activity (GO:0010951)3.29924515
70response to misfolded protein (GO:0051788)3.29276540
71positive regulation of mRNA 3-end processing (GO:0031442)3.28596075
72mesenchymal to epithelial transition (GO:0060231)3.24550865
73negative regulation of peptidase activity (GO:0010466)3.20145615
74negative regulation of epidermal cell differentiation (GO:0045605)3.20015892
75cranial nerve structural organization (GO:0021604)3.19788977
76white fat cell differentiation (GO:0050872)3.15623846
77cell differentiation in spinal cord (GO:0021515)3.15150820
78sodium-independent organic anion transport (GO:0043252)3.14945514
79low-density lipoprotein particle clearance (GO:0034383)3.14849086
80metanephric mesenchyme development (GO:0072075)3.13199423
81negative regulation of systemic arterial blood pressure (GO:0003085)3.12112112
82fibroblast migration (GO:0010761)3.10935894
83regulation of hydrogen peroxide-induced cell death (GO:1903205)3.10281616
84regulation of mRNA catabolic process (GO:0061013)3.09747128
85cell differentiation in hindbrain (GO:0021533)3.08952611
86forebrain neuron differentiation (GO:0021879)3.06291571
87platelet dense granule organization (GO:0060155)3.04405898
88intra-S DNA damage checkpoint (GO:0031573)3.03051082
89regulation of metanephros development (GO:0072215)2.99248441
90regulation of mRNA 3-end processing (GO:0031440)2.98390458
91nephron tubule development (GO:0072080)2.97779116
92smooth muscle contraction (GO:0006939)2.97360046
93positive regulation of cellular response to oxidative stress (GO:1900409)2.93956401
94positive regulation of response to oxidative stress (GO:1902884)2.93956401
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90657677
96indole-containing compound metabolic process (GO:0042430)2.89735307
97exploration behavior (GO:0035640)2.88488222
98regulation of coenzyme metabolic process (GO:0051196)2.86670601
99regulation of cofactor metabolic process (GO:0051193)2.86670601
100embryonic epithelial tube formation (GO:0001838)2.86618062
101valine metabolic process (GO:0006573)2.86151105
102positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.84315841
103regulation of fatty acid oxidation (GO:0046320)2.82975223
104negative regulation of metanephros development (GO:0072217)2.82093780
105positive regulation of action potential (GO:0045760)2.81753794
106regulation of stem cell maintenance (GO:2000036)2.79293122
107phosphatidylserine acyl-chain remodeling (GO:0036150)2.78197093
108positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.77962324
109specification of organ identity (GO:0010092)2.76239521
110positive regulation of natural killer cell activation (GO:0032816)2.75873693
111regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75399202
112regulation of glomerulus development (GO:0090192)2.75295646
113regulation of sulfur metabolic process (GO:0042762)2.74867400
114negative regulation of protein autophosphorylation (GO:0031953)2.74362075
115positive regulation of mesonephros development (GO:0061213)2.74330883
116epithelial tube formation (GO:0072175)2.72766398
117regulation of gene silencing by RNA (GO:0060966)2.72686658
118regulation of posttranscriptional gene silencing (GO:0060147)2.72686658
119regulation of gene silencing by miRNA (GO:0060964)2.72686658
120indole-containing compound catabolic process (GO:0042436)2.71784834
121indolalkylamine catabolic process (GO:0046218)2.71784834
122tryptophan catabolic process (GO:0006569)2.71784834
123phospholipid catabolic process (GO:0009395)2.71291455
124cellular anion homeostasis (GO:0030002)2.67204563
125regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.67083318
126positive regulation of respiratory burst (GO:0060267)2.63498469
127triglyceride catabolic process (GO:0019433)2.58911525
128nephron tubule formation (GO:0072079)2.58222217
129phosphate ion homeostasis (GO:0055062)2.56108723
130trivalent inorganic anion homeostasis (GO:0072506)2.56108723
131regulation of calcium ion-dependent exocytosis (GO:0017158)2.55373330
132polyol transport (GO:0015791)2.53593451
133negative regulation of endocytosis (GO:0045806)2.52818095
134negative regulation of lipase activity (GO:0060192)2.49361152
135positive regulation of cholesterol transport (GO:0032376)2.46939451
136positive regulation of sterol transport (GO:0032373)2.46939451
137epithelial cell differentiation involved in kidney development (GO:0035850)2.46581333
138cytolysis (GO:0019835)2.44663068
139pyrimidine nucleobase catabolic process (GO:0006208)2.43380371
140embryonic digestive tract morphogenesis (GO:0048557)2.43373854
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43329619
142xenobiotic catabolic process (GO:0042178)2.41316543
143regulation of complement activation (GO:0030449)2.40692444
144positive regulation of glomerulus development (GO:0090193)2.37354472
145cellular response to heat (GO:0034605)2.37316713
146limb bud formation (GO:0060174)2.36977996
147negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.35936590
148acylglycerol catabolic process (GO:0046464)2.35195575
149neutral lipid catabolic process (GO:0046461)2.35195575
150negative regulation of viral transcription (GO:0032897)2.35019046
151endosome to pigment granule transport (GO:0043485)2.29808630
152endosome to melanosome transport (GO:0035646)2.29808630
153negative regulation of epidermis development (GO:0045683)2.27446512
154regulation of protein activation cascade (GO:2000257)2.23594297
155cellular sodium ion homeostasis (GO:0006883)2.23232871
156cellular component maintenance (GO:0043954)2.21920994
157positive regulation of receptor biosynthetic process (GO:0010870)2.20965088
158regulation of response to reactive oxygen species (GO:1901031)2.16947988
159nucleobase catabolic process (GO:0046113)2.16920052
160negative regulation of reactive oxygen species metabolic process (GO:2000378)2.16742109
161negative regulation of proteolysis (GO:0045861)2.15678710
162negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.15619156
163mannose metabolic process (GO:0006013)2.12236058
164cranial nerve morphogenesis (GO:0021602)2.11980963
165negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.11420261
166positive regulation of filopodium assembly (GO:0051491)2.11334196
167mesonephros development (GO:0001823)2.09927529
168regulation of mesenchymal cell apoptotic process (GO:2001053)2.09165729
169regulation of natural killer cell activation (GO:0032814)2.09047579
170retina vasculature morphogenesis in camera-type eye (GO:0061299)2.08396436
171anterograde synaptic vesicle transport (GO:0048490)2.08223374
172response to nitrosative stress (GO:0051409)2.08212974
173metanephric nephron tubule development (GO:0072234)2.07333389
174metanephric tubule development (GO:0072170)2.07333389
175cellular response to epinephrine stimulus (GO:0071872)2.07172372
176regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.07019729
177glomerular filtration (GO:0003094)2.06696988
178developmental pigmentation (GO:0048066)2.06523909
179negative regulation of oxidoreductase activity (GO:0051354)2.06162301
180photoreceptor cell differentiation (GO:0046530)2.04083838
181eye photoreceptor cell differentiation (GO:0001754)2.04083838
182positive regulation of digestive system process (GO:0060456)2.03962478
183sexual reproduction (GO:0019953)15.9902990
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)15.4449624
185antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)15.4449624
186antigen processing and presentation via MHC class Ib (GO:0002475)14.9445710
187regulation of antigen processing and presentation of peptide antigen (GO:0002583)14.4281985
188antigen processing and presentation of endogenous antigen (GO:0019883)12.9153810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human8.07524443
2IGF1R_20145208_ChIP-Seq_DFB_Human4.29136203
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.40820098
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.84575352
5TAF15_26573619_Chip-Seq_HEK293_Human2.58406204
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55532088
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.40405017
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28084032
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21520942
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.17307080
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.06393247
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04931557
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04274968
14AR_21572438_ChIP-Seq_LNCaP_Human2.02121372
15IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93789080
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90031307
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.88521067
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84198846
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84198846
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83819248
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.83657518
22ZNF274_21170338_ChIP-Seq_K562_Hela1.80853483
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.79860206
24TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74342293
25STAT3_23295773_ChIP-Seq_U87_Human1.73607091
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72783215
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71771195
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68452043
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68452043
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68424488
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67222563
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65362598
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64779653
34EZH2_22144423_ChIP-Seq_EOC_Human1.60212021
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59272407
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59261036
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58086682
38ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55928589
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55302144
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53617975
41STAT1_17558387_ChIP-Seq_HELA_Human1.51690893
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.49331932
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44801901
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.43590178
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42444992
46TP53_16413492_ChIP-PET_HCT116_Human1.42185585
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41900383
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.40825697
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39805734
50TCF4_23295773_ChIP-Seq_U87_Human1.37177191
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36350613
52* AR_25329375_ChIP-Seq_VCAP_Human1.35806184
53RNF2_27304074_Chip-Seq_NSC_Mouse1.35062270
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33842222
55VDR_24787735_ChIP-Seq_THP-1_Human1.31849941
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31045796
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.24812599
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24360962
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.24173011
60HTT_18923047_ChIP-ChIP_STHdh_Human1.23658916
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21108625
62SOX2_20726797_ChIP-Seq_SW620_Human1.20641347
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20379609
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19739787
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.19659256
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.18249864
67TP53_18474530_ChIP-ChIP_U2OS_Human1.17968460
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17562170
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17504165
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16429204
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16187106
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16120839
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15802786
74REST_21632747_ChIP-Seq_MESCs_Mouse1.15733628
75SMAD3_21741376_ChIP-Seq_ESCs_Human1.15688682
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.15217376
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14661056
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14300263
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13768673
80MYC_19915707_ChIP-ChIP_AK7_Human1.13021069
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12947360
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11876724
83ER_23166858_ChIP-Seq_MCF-7_Human1.11100990
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.10670741
85GBX2_23144817_ChIP-Seq_PC3_Human1.09098862
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08737675
87SMAD4_21799915_ChIP-Seq_A2780_Human1.08599410
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08216515
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07077425
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.07077425
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.06871350
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06458846
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06359847
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04546394
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04546394
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.04539947
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04532268
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04444281
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03684473
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02357796
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.01558606
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00665298
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00169062
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00091800
105P300_19829295_ChIP-Seq_ESCs_Human0.98437754
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.97873019
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97262172
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97212310
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97170864
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96640858
111CSB_26484114_Chip-Seq_FIBROBLAST_Human0.95691745
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95443898
113GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95217302
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94624426
115AR_19668381_ChIP-Seq_PC3_Human0.94605864
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94497116
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94473957
118RUNX2_22187159_ChIP-Seq_PCA_Human0.94340346
119KDM2B_26808549_Chip-Seq_REH_Human0.92923624
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92717479
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.91626714
122ZNF263_19887448_ChIP-Seq_K562_Human0.91054123
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90533961
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.90454346
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89691675
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.89105802
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.88762842
128CBX2_27304074_Chip-Seq_ESCs_Mouse0.87569754
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.87120081
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87068793
131LXR_22158963_ChIP-Seq_LIVER_Mouse0.86071543
132BCAT_22108803_ChIP-Seq_LS180_Human0.85653598
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84760995
134AHR_22903824_ChIP-Seq_MCF-7_Human0.84740595
135EP300_21415370_ChIP-Seq_HL-1_Mouse0.84106859
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83561141
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82354852
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82056124
139VDR_22108803_ChIP-Seq_LS180_Human0.81727872
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81528708
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80508415
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80042317
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79578170
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.78911035
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78765777
146DROSHA_22980978_ChIP-Seq_HELA_Human0.78752719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology8.17142063
2MP0009840_abnormal_foam_cell4.96052490
3MP0005058_abnormal_lysosome_morphology4.02088008
4MP0005174_abnormal_tail_pigmentation3.30937446
5MP0009379_abnormal_foot_pigmentation3.23022099
6MP0002653_abnormal_ependyma_morphology3.06545345
7MP0000534_abnormal_ureter_morphology3.01666029
8MP0001485_abnormal_pinna_reflex2.60725739
9MP0000372_irregular_coat_pigmentation2.59316908
10MP0003136_yellow_coat_color2.52354491
11MP0005670_abnormal_white_adipose2.50658192
12MP0003646_muscle_fatigue2.46551553
13MP0004145_abnormal_muscle_electrophysio2.29881435
14MP0001756_abnormal_urination2.17312623
15MP0003172_abnormal_lysosome_physiology2.14284600
16MP0000462_abnormal_digestive_system2.11612464
17MP0008995_early_reproductive_senescence2.08866379
18MP0000538_abnormal_urinary_bladder2.08283243
19MP0000767_abnormal_smooth_muscle2.01356328
20MP0000778_abnormal_nervous_system1.98345013
21MP0003938_abnormal_ear_development1.94733598
22MP0000230_abnormal_systemic_arterial1.93254228
23MP0005171_absent_coat_pigmentation1.88737722
24MP0001501_abnormal_sleep_pattern1.87815432
25MP0000015_abnormal_ear_pigmentation1.87061922
26MP0002139_abnormal_hepatobiliary_system1.85669482
27MP0004381_abnormal_hair_follicle1.84152175
28MP0003690_abnormal_glial_cell1.83788969
29MP0001853_heart_inflammation1.83218297
30MP0001664_abnormal_digestion1.81600915
31MP0005360_urolithiasis1.76734839
32MP0002638_abnormal_pupillary_reflex1.75853219
33MP0002282_abnormal_trachea_morphology1.71515142
34MP0003656_abnormal_erythrocyte_physiolo1.70317564
35MP0004019_abnormal_vitamin_homeostasis1.66251403
36MP0003950_abnormal_plasma_membrane1.62059989
37MP0005645_abnormal_hypothalamus_physiol1.60295351
38MP0004858_abnormal_nervous_system1.59883890
39MP0008875_abnormal_xenobiotic_pharmacok1.59577395
40MP0003942_abnormal_urinary_system1.56171981
41MP0002735_abnormal_chemical_nociception1.54664587
42MP0001502_abnormal_circadian_rhythm1.50205298
43MP0002876_abnormal_thyroid_physiology1.49269910
44MP0010386_abnormal_urinary_bladder1.45955962
45MP0005595_abnormal_vascular_smooth1.44159977
46MP0003045_fibrosis1.44088584
47MP0005620_abnormal_muscle_contractility1.44043327
48MP0001324_abnormal_eye_pigmentation1.43684219
49MP0004036_abnormal_muscle_relaxation1.43519964
50MP0009764_decreased_sensitivity_to1.41585050
51MP0003195_calcinosis1.40580145
52MP0005646_abnormal_pituitary_gland1.39312605
53MP0000427_abnormal_hair_cycle1.37622541
54MP0009785_altered_susceptibility_to1.37425135
55MP0005666_abnormal_adipose_tissue1.37214868
56MP0002272_abnormal_nervous_system1.35485997
57MP0005248_abnormal_Harderian_gland1.33874477
58MP0002148_abnormal_hypersensitivity_rea1.32141990
59MP0004130_abnormal_muscle_cell1.31042363
60MP0006082_CNS_inflammation1.29002452
61MP0009763_increased_sensitivity_to1.25759670
62MP0003724_increased_susceptibility_to1.25612194
63MP0005551_abnormal_eye_electrophysiolog1.24808338
64MP0010368_abnormal_lymphatic_system1.23510046
65MP0002734_abnormal_mechanical_nocicepti1.22385944
66MP0010329_abnormal_lipoprotein_level1.18930692
67MP0002060_abnormal_skin_morphology1.18572000
68MP0003075_altered_response_to1.18426876
69MP0000647_abnormal_sebaceous_gland1.17962830
70MP0001440_abnormal_grooming_behavior1.15490649
71MP0005375_adipose_tissue_phenotype1.14477749
72MP0003186_abnormal_redox_activity1.13350356
73MP0000371_diluted_coat_color1.13156516
74MP0003936_abnormal_reproductive_system1.13106559
75MP0000631_abnormal_neuroendocrine_gland1.13071401
76MP0008569_lethality_at_weaning1.11331570
77MP0005167_abnormal_blood-brain_barrier1.08452860
78MP0008438_abnormal_cutaneous_collagen1.08310365
79MP0002234_abnormal_pharynx_morphology1.07676617
80MP0001963_abnormal_hearing_physiology1.06844349
81MP0004272_abnormal_basement_membrane1.02747738
82MP0003953_abnormal_hormone_level1.01931790
83MP0003191_abnormal_cellular_cholesterol1.01538881
84MP0001486_abnormal_startle_reflex0.97750714
85MP0001270_distended_abdomen0.97402335
86MP0003890_abnormal_embryonic-extraembry0.96038029
87MP0004885_abnormal_endolymph0.95573754
88MP0009745_abnormal_behavioral_response0.95525332
89MP0008961_abnormal_basal_metabolism0.94853625
90MP0005275_abnormal_skin_tensile0.94211294
91MP0000343_altered_response_to0.91742631
92MP0002118_abnormal_lipid_homeostasis0.91674137
93MP0005386_behavior/neurological_phenoty0.91510589
94MP0004924_abnormal_behavior0.91510589
95MP0002067_abnormal_sensory_capabilities0.91158227
96MP0002736_abnormal_nociception_after0.90391367
97MP0000685_abnormal_immune_system0.90149216
98MP0000681_abnormal_thyroid_gland0.90082349
99MP0000026_abnormal_inner_ear0.89999049
100MP0002168_other_aberrant_phenotype0.89415098
101MP0001727_abnormal_embryo_implantation0.89132157
102MP0005310_abnormal_salivary_gland0.88425828
103MP0003436_decreased_susceptibility_to0.87779013
104MP0003137_abnormal_impulse_conducting0.86144537
105MP0004085_abnormal_heartbeat0.85233384
106MP0002069_abnormal_eating/drinking_beha0.84823231
107MP0003879_abnormal_hair_cell0.84082899
108MP0003632_abnormal_nervous_system0.83358712
109MP0003937_abnormal_limbs/digits/tail_de0.82711021
110MP0005636_abnormal_mineral_homeostasis0.82402062
111MP0002557_abnormal_social/conspecific_i0.82349283
112MP0000579_abnormal_nail_morphology0.82039235
113MP0006292_abnormal_olfactory_placode0.81767253
114MP0005330_cardiomyopathy0.81661144
115MP0009780_abnormal_chondrocyte_physiolo0.81391586
116MP0002064_seizures0.81137416
117MP0001968_abnormal_touch/_nociception0.80984026
118MP0000377_abnormal_hair_follicle0.80886322
119MP0005187_abnormal_penis_morphology0.80576310
120MP0001879_abnormal_lymphatic_vessel0.80531184
121MP0004134_abnormal_chest_morphology0.80406043
122MP0005075_abnormal_melanosome_morpholog0.80316785
123MP0004859_abnormal_synaptic_plasticity0.79658822
124MP0009046_muscle_twitch0.79216367
125MP0005025_abnormal_response_to0.79115831
126MP0008872_abnormal_physiological_respon0.78848453
127MP0008004_abnormal_stomach_pH0.78629075
128MP0002063_abnormal_learning/memory/cond0.77563626
129MP0004142_abnormal_muscle_tone0.76849917
130MP0005584_abnormal_enzyme/coenzyme_acti0.76786601
131MP0005381_digestive/alimentary_phenotyp0.76710916
132MP0000566_synostosis0.76093542
133MP0002006_tumorigenesis0.74941415
134MP0002837_dystrophic_cardiac_calcinosis0.74888059
135MP0001188_hyperpigmentation0.74407699
136MP0000569_abnormal_digit_pigmentation0.73871365
137MP0003635_abnormal_synaptic_transmissio0.73810602
138MP0005334_abnormal_fat_pad0.73803345
139MP0005000_abnormal_immune_tolerance0.73306223
140MP0003943_abnormal_hepatobiliary_system0.72938147
141MP0005408_hypopigmentation0.72917913
142MP0002332_abnormal_exercise_endurance0.72511885
143MP0005220_abnormal_exocrine_pancreas0.72264469
144MP0005365_abnormal_bile_salt0.72126008
145MP0008775_abnormal_heart_ventricle0.71278725
146MP0004947_skin_inflammation0.71193273
147MP0002419_abnormal_innate_immunity0.71177637
148MP0009643_abnormal_urine_homeostasis0.70112597
149MP0002572_abnormal_emotion/affect_behav0.69621459
150MP0002882_abnormal_neuron_morphology0.69507941
151MP0001970_abnormal_pain_threshold0.69342624
152MP0002136_abnormal_kidney_physiology0.69031177
153MP0003183_abnormal_peptide_metabolism0.68787088
154MP0004270_analgesia0.68464779
155MP0003806_abnormal_nucleotide_metabolis0.68016525
156MP0009115_abnormal_fat_cell0.67874307
157MP0001765_abnormal_ion_homeostasis0.66907277
158MP0002152_abnormal_brain_morphology0.66092205
159MP0001790_abnormal_immune_system0.65944343
160MP0005387_immune_system_phenotype0.65944343
161MP0005195_abnormal_posterior_eye0.65566660
162MP0003698_abnormal_male_reproductive0.65547092
163MP0002177_abnormal_outer_ear0.65217413
164MP0001835_abnormal_antigen_presentation0.65188471
165MP0005448_abnormal_energy_balance0.64999927
166MP0000920_abnormal_myelination0.64850123
167MP0002229_neurodegeneration0.64637693
168MP0001533_abnormal_skeleton_physiology0.64317417
169MP0003638_abnormal_response/metabolism_0.64301375
170MP0004185_abnormal_adipocyte_glucose0.63799510
171MP0000163_abnormal_cartilage_morphology0.63516174

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)7.61458016
2Choroideremia (HP:0001139)7.58958715
3Abnormality of the fovea (HP:0000493)7.34437540
4Abnormality of the axillary hair (HP:0100134)6.79490401
5Abnormality of secondary sexual hair (HP:0009888)6.79490401
6Abnormal rod and cone electroretinograms (HP:0008323)6.43555384
7Vacuolated lymphocytes (HP:0001922)6.23915402
8Genetic anticipation (HP:0003743)6.02010812
9Recurrent gram-negative bacterial infections (HP:0005420)5.61083352
10Bony spicule pigmentary retinopathy (HP:0007737)5.34221588
11Complement deficiency (HP:0004431)5.20484403
1211 pairs of ribs (HP:0000878)4.79232193
13Aortic aneurysm (HP:0004942)4.43622663
14Acute lymphatic leukemia (HP:0006721)4.27680826
15Hyperventilation (HP:0002883)4.25255910
16Hypopigmentation of the fundus (HP:0007894)4.06808548
17Shawl scrotum (HP:0000049)4.01379809
18Abnormality of complement system (HP:0005339)3.95403939
19Chorioretinal atrophy (HP:0000533)3.88004102
20Stridor (HP:0010307)3.86558874
21Hypothermia (HP:0002045)3.86257816
22Action tremor (HP:0002345)3.85515302
23Breast hypoplasia (HP:0003187)3.52076510
24Clumsiness (HP:0002312)3.49935140
25Nonprogressive disorder (HP:0003680)3.49225418
26Vascular calcification (HP:0004934)3.45070466
27Neurofibrillary tangles (HP:0002185)3.39338160
28Congenital sensorineural hearing impairment (HP:0008527)3.37713906
29Reticulocytopenia (HP:0001896)3.25856865
30Protruding tongue (HP:0010808)3.25667658
31Hand muscle atrophy (HP:0009130)3.22896233
32Broad-based gait (HP:0002136)3.20684035
33Hip contracture (HP:0003273)3.15655990
34Diaphragmatic weakness (HP:0009113)3.12106791
35Cardiovascular calcification (HP:0011915)3.11355857
36Tongue fasciculations (HP:0001308)3.08373750
37Hyperphosphatemia (HP:0002905)3.05558175
38Blue irides (HP:0000635)3.02567611
39Aplasia of the musculature (HP:0100854)3.01625491
40Dysmetric saccades (HP:0000641)2.99927476
41Missing ribs (HP:0000921)2.93297373
42Visual hallucinations (HP:0002367)2.90589250
43Cerebral inclusion bodies (HP:0100314)2.88188106
44Bronchomalacia (HP:0002780)2.84606101
45Gaze-evoked nystagmus (HP:0000640)2.83008854
46Muscle fibrillation (HP:0010546)2.77944923
47Hyperglycinuria (HP:0003108)2.77912607
48Limited hip movement (HP:0008800)2.75869476
49Clubbing of toes (HP:0100760)2.75587344
50Wide cranial sutures (HP:0010537)2.72110859
51Polydipsia (HP:0001959)2.70504075
52Abnormal drinking behavior (HP:0030082)2.70504075
53Widely patent fontanelles and sutures (HP:0004492)2.68848147
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.67201384
55Aplasia involving bones of the upper limbs (HP:0009823)2.63893944
56Aplasia of the phalanges of the hand (HP:0009802)2.63893944
57Aplasia involving bones of the extremities (HP:0009825)2.63893944
58Congenital stationary night blindness (HP:0007642)2.62355523
59Limb ataxia (HP:0002070)2.61927417
60Duplicated collecting system (HP:0000081)2.59525121
61Hypoplastic nipples (HP:0002557)2.58781129
62Abnormality of macrophages (HP:0004311)2.57225625
63Aortic dissection (HP:0002647)2.55005641
64Abnormality of macular pigmentation (HP:0008002)2.54838376
65Upper limb amyotrophy (HP:0009129)2.54769218
66Distal upper limb amyotrophy (HP:0007149)2.54769218
67Tubulointerstitial fibrosis (HP:0005576)2.54122743
68Macroglossia (HP:0000158)2.54068390
69Confusion (HP:0001289)2.53967503
70Metaphyseal cupping (HP:0003021)2.53854528
71Partial duplication of thumb phalanx (HP:0009944)2.50269241
72Ventricular fibrillation (HP:0001663)2.45041908
73Decreased circulating renin level (HP:0003351)2.42220218
74Sparse lateral eyebrow (HP:0005338)2.41963058
75Potter facies (HP:0002009)2.40776622
76Facial shape deformation (HP:0011334)2.40776622
77Thyroid-stimulating hormone excess (HP:0002925)2.38253803
78Patellar aplasia (HP:0006443)2.36779713
79Abnormality of cochlea (HP:0000375)2.34952505
80Fair hair (HP:0002286)2.33493109
81Goiter (HP:0000853)2.33325575
82Hypophosphatemic rickets (HP:0004912)2.31989583
83Intention tremor (HP:0002080)2.28545746
84Cerebral palsy (HP:0100021)2.27546267
85Pili torti (HP:0003777)2.24740104
86Neoplasm of the heart (HP:0100544)2.24547112
87Abnormality of the parietal bone (HP:0002696)2.23631819
88Prolonged QT interval (HP:0001657)2.21993455
89Facial diplegia (HP:0001349)2.19576803
90Nasolacrimal duct obstruction (HP:0000579)2.16975993
91Abnormality of the nasal septum (HP:0000419)2.16649015
92Albinism (HP:0001022)2.15103494
93Seborrheic dermatitis (HP:0001051)2.14939914
94Irregular vertebral endplates (HP:0003301)2.14922707
95Biconcave vertebral bodies (HP:0004586)2.14782390
96Aortic regurgitation (HP:0001659)2.13748577
97Osteomalacia (HP:0002749)2.13180359
98Bone cyst (HP:0012062)2.12852176
99Partial duplication of the phalanx of hand (HP:0009999)2.12265701
100Hypertriglyceridemia (HP:0002155)2.12010744
101Generalized hypopigmentation of hair (HP:0011358)2.11057840
102Absent radius (HP:0003974)2.10950165
103Aplasia/Hypoplasia of the patella (HP:0006498)2.10934745
104Premature loss of primary teeth (HP:0006323)2.09944449
105Short humerus (HP:0005792)2.06507529
106Loss of speech (HP:0002371)2.06292829
107Myocardial infarction (HP:0001658)2.05706972
108Oligomenorrhea (HP:0000876)2.05657965
109Dysostosis multiplex (HP:0000943)2.05304116
110Duplication of thumb phalanx (HP:0009942)2.05266112
111Agitation (HP:0000713)2.05197427
112Absent hair (HP:0002298)2.04440210
113Inability to walk (HP:0002540)2.03764734
114Morphological abnormality of the inner ear (HP:0011390)2.03639430
115Absent forearm bone (HP:0003953)2.03127669
116Aplasia involving forearm bones (HP:0009822)2.03127669
117Absent speech (HP:0001344)2.02224526
118Abnormality of serine family amino acid metabolism (HP:0010894)2.01277902
119Abnormality of glycine metabolism (HP:0010895)2.01277902
120Eczematoid dermatitis (HP:0000976)2.01239891
121Ankle clonus (HP:0011448)2.00476889
122Abnormality of the renal collecting system (HP:0004742)1.98569966
123Abnormality of the musculature of the hand (HP:0001421)1.98059817
124Hypoplastic labia majora (HP:0000059)1.96721385
125Bicornuate uterus (HP:0000813)1.95172611
126Hypoplasia of the maxilla (HP:0000327)1.94049219
127Down-sloping shoulders (HP:0200021)1.94043712
128Flat cornea (HP:0007720)1.93902704
129Progressive inability to walk (HP:0002505)1.93428908
130Supranuclear gaze palsy (HP:0000605)1.92799541
131Systemic lupus erythematosus (HP:0002725)1.92468020
132Infantile muscular hypotonia (HP:0008947)1.88524347
133Vaginal atresia (HP:0000148)1.87440330
134Xerostomia (HP:0000217)1.87177981
135Abnormality of alanine metabolism (HP:0010916)1.85917690
136Hyperalaninemia (HP:0003348)1.85917690
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85917690
138Abnormality of the calcaneus (HP:0008364)1.85469259
139Polyuria (HP:0000103)1.84982170
140Tracheomalacia (HP:0002779)1.84803462
141Hemiplegia (HP:0002301)1.82965342
142Polar cataract (HP:0010696)1.79965943
143Fibular hypoplasia (HP:0003038)1.78289572
144Genital tract atresia (HP:0001827)1.78043504
145Birth length less than 3rd percentile (HP:0003561)1.78042198
146Abnormality of the labia majora (HP:0012881)1.77921055
147Hyperglycinemia (HP:0002154)1.77740722
148Abnormality of the vocal cords (HP:0008777)1.77431930
149Hypoventilation (HP:0002791)1.76105218
150Midline defect of the nose (HP:0004122)1.75467535
151Chromsome breakage (HP:0040012)1.75274645
152Focal segmental glomerulosclerosis (HP:0000097)1.74666715
153Periodontitis (HP:0000704)1.74504383
154Hypoplasia of the ulna (HP:0003022)1.73868861
155Chin dimple (HP:0010751)1.73112515
156Short tibia (HP:0005736)1.72701321
157Acanthosis nigricans (HP:0000956)1.71948896
158Aplasia/hypoplasia of the humerus (HP:0006507)1.71939337
159White forelock (HP:0002211)1.71231672
160Morphological abnormality of the pyramidal tract (HP:0002062)1.71025711
161True hermaphroditism (HP:0010459)1.70592452
162Truncal obesity (HP:0001956)1.70418393
163Abnormality of midbrain morphology (HP:0002418)1.69790723
164Molar tooth sign on MRI (HP:0002419)1.69790723
165Neck muscle weakness (HP:0000467)1.69617550
166Pigmentary retinal degeneration (HP:0001146)1.69240802
167Hyperpituitarism (HP:0010514)1.67314452
168Tibial bowing (HP:0002982)1.67250256
169Inappropriate behavior (HP:0000719)1.66923846
170Abnormality of the lumbar spine (HP:0100712)1.66163809
171Hemorrhage of the eye (HP:0011885)1.65929027
172Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.64960649
173Laryngomalacia (HP:0001601)1.64256272
174Widely spaced teeth (HP:0000687)1.64080110
175Ketoacidosis (HP:0001993)1.63874546
176Pancreatic fibrosis (HP:0100732)1.63858035
177Distal lower limb muscle weakness (HP:0009053)1.63788524
178Abnormality of sulfur amino acid metabolism (HP:0004339)1.63004731
179Subcapsular cataract (HP:0000523)1.61553028
180Macular degeneration (HP:0000608)1.61011691
181Cone-rod dystrophy (HP:0000548)1.58782586
182Alacrima (HP:0000522)1.57767387
183Abnormality of the 4th metacarpal (HP:0010012)1.57135107
184Central scotoma (HP:0000603)1.55332056
185Hydroureter (HP:0000072)1.54883497
186Aplasia cutis congenita (HP:0001057)1.54515443
187Generalized hypopigmentation (HP:0007513)1.54021401
188Abnormal ciliary motility (HP:0012262)1.53534678
189Reduced subcutaneous adipose tissue (HP:0003758)1.53464536
190Growth hormone excess (HP:0000845)1.53124969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.13566233
2AKT37.07443297
3FRK6.63083469
4MAP3K94.39743327
5RIPK43.21603545
6IRAK33.16506215
7ACVR1B2.84064447
8MAP3K132.82888895
9WNK42.59008057
10LATS12.56907153
11TLK12.44056546
12MAP2K62.24912620
13ZAK2.17862974
14LMTK22.08762647
15TAOK31.96842326
16MYLK1.93925909
17EPHA31.85361719
18CASK1.81420466
19INSRR1.80497881
20EPHB11.79089232
21FGFR41.77781256
22IRAK41.77154290
23CAMK1G1.57495407
24BLK1.54999035
25SGK21.44080614
26NTRK11.40740846
27IRAK21.39998926
28EPHB21.38717924
29EPHA41.38584616
30IRAK11.37265945
31CAMK1D1.31811637
32PNCK1.29185936
33PTK2B1.27853662
34DMPK1.27630868
35NTRK21.23110606
36MST41.19021700
37TEC1.16586193
38CDK121.15851596
39SIK11.15222142
40MARK11.07058043
41JAK11.06850816
42STK391.05524035
43TGFBR11.04399334
44WNK10.98861494
45NUAK10.97318458
46ERN10.96171945
47PIK3CA0.95625436
48NEK20.93428197
49GRK50.93208666
50TXK0.90786431
51PIK3CG0.90381389
52TNK20.90037727
53SGK4940.89090979
54SGK2230.89090979
55ARAF0.89067932
56MAP2K40.89049033
57PAK30.88807420
58MATK0.85375104
59RIPK10.84124289
60TNIK0.83284480
61SGK30.82624042
62CDC42BPA0.81607120
63NTRK30.81124977
64MAP3K140.81090778
65DAPK20.80118813
66MKNK20.79715653
67MUSK0.79476780
68EIF2AK20.78439454
69PRKCH0.76690701
70BMX0.76157080
71TAOK10.72614152
72SGK10.71810587
73CHUK0.69950009
74JAK20.69747918
75TRPM70.69655665
76STK380.69231673
77MAPK40.69008255
78SIK20.68830577
79DAPK30.68026076
80STK160.67014323
81ERBB40.66628445
82MAPK110.66562722
83ADRBK10.66430960
84FGR0.66241455
85PDK20.64641925
86DDR20.63821193
87MAP3K70.63712077
88BCR0.63711046
89PKN10.63462437
90MAPKAPK30.63267235
91ADRBK20.62721415
92MAP2K10.62318646
93MAP3K120.60881596
94NEK90.60323242
95FLT30.60207666
96EEF2K0.58645561
97TTN0.58598818
98BMPR1B0.56723220
99CSK0.56405303
100CDK190.55357969
101FYN0.55295590
102TRIB30.54441807
103MAP3K40.54299605
104SYK0.51804081
105PRKAA20.50629543
106PRPF4B0.50513855
107MARK30.48168057
108EGFR0.47520640
109FGFR20.47162338
110TBK10.47055682
111HIPK20.45933012
112STK30.45748941
113MOS0.44965975
114MINK10.43876340
115MARK20.43837416
116PTK20.43134832
117PDK10.42513425
118WNK30.42151077
119BCKDK0.41745079
120LYN0.41662466
121CAMK10.41166002
122MTOR0.41082097
123GRK60.40695336
124CDK50.40581031
125KIT0.39724830
126JAK30.39723872
127SRC0.39424472
128RET0.38445612
129GRK70.38415813
130PRKCZ0.37491286
131MST1R0.37002482
132MAPK130.36621979
133BMPR20.36434806
134PRKACG0.35500420
135LRRK20.35215549
136MAP3K60.34914699
137PRKCE0.34836707
138PRKACA0.33986678
139CAMK2A0.33912595
140MAPK10.33137023
141ROCK10.33039916
142RPS6KA20.32853578
143PHKG20.32282114
144PHKG10.32282114
145MET0.32145599
146PRKCD0.31905636
147PLK20.31706242
148PAK20.31029313
149FER0.30546906
150MAP2K70.30328546
151ALK0.30197928
152NLK0.30036968
153MAP3K20.28943133
154PRKACB0.27278705
155MAPK80.26938102
156RPS6KA60.26840593
157GSK3B0.26686142
158WEE10.26650857
159MKNK10.23558856
160ERBB30.21358219
161CAMK40.21017316
162ICK0.20995247
163AKT10.20983084
164STK110.19083509
165GRK10.16550869
166PRKG10.16383502
167MAPK140.16280217

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.18192852
2Other glycan degradation_Homo sapiens_hsa005113.02309766
3ABC transporters_Homo sapiens_hsa020102.97803631
4Sulfur metabolism_Homo sapiens_hsa009202.79420077
5Phototransduction_Homo sapiens_hsa047442.48059569
6PPAR signaling pathway_Homo sapiens_hsa033202.42217490
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26874236
8Circadian rhythm_Homo sapiens_hsa047102.21182150
9Staphylococcus aureus infection_Homo sapiens_hsa051502.17638983
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16514930
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.13435252
12Fatty acid degradation_Homo sapiens_hsa000712.07950524
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05165962
14Serotonergic synapse_Homo sapiens_hsa047261.98073046
15Long-term depression_Homo sapiens_hsa047301.92312841
16Fatty acid metabolism_Homo sapiens_hsa012121.90034198
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81996910
18Lysine degradation_Homo sapiens_hsa003101.78475075
19Dorso-ventral axis formation_Homo sapiens_hsa043201.78201830
20Ether lipid metabolism_Homo sapiens_hsa005651.76658278
21Prion diseases_Homo sapiens_hsa050201.70196310
22Tyrosine metabolism_Homo sapiens_hsa003501.68780788
23beta-Alanine metabolism_Homo sapiens_hsa004101.68155210
24Salivary secretion_Homo sapiens_hsa049701.67001841
25Phenylalanine metabolism_Homo sapiens_hsa003601.65818545
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63728260
27Glycerolipid metabolism_Homo sapiens_hsa005611.60816497
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60539753
29Vitamin digestion and absorption_Homo sapiens_hsa049771.57050300
30Complement and coagulation cascades_Homo sapiens_hsa046101.42174654
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39962046
32Pertussis_Homo sapiens_hsa051331.36161071
33Oxytocin signaling pathway_Homo sapiens_hsa049211.30378311
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29966572
35Insulin secretion_Homo sapiens_hsa049111.29415969
36Selenocompound metabolism_Homo sapiens_hsa004501.25959262
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24230710
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.18667896
39Fat digestion and absorption_Homo sapiens_hsa049751.16255878
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14018911
41Dopaminergic synapse_Homo sapiens_hsa047281.12977014
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.12871834
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12149142
44Basal cell carcinoma_Homo sapiens_hsa052171.11966237
45Leishmaniasis_Homo sapiens_hsa051401.11765960
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10787206
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10210701
48Melanogenesis_Homo sapiens_hsa049161.08703158
49Type I diabetes mellitus_Homo sapiens_hsa049401.08152247
50Lysosome_Homo sapiens_hsa041421.08016211
51Propanoate metabolism_Homo sapiens_hsa006401.07524332
52Graft-versus-host disease_Homo sapiens_hsa053321.06133297
53Choline metabolism in cancer_Homo sapiens_hsa052311.04030525
54Taste transduction_Homo sapiens_hsa047421.03142112
55Allograft rejection_Homo sapiens_hsa053301.02915631
56African trypanosomiasis_Homo sapiens_hsa051431.02217453
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01426510
58Renin secretion_Homo sapiens_hsa049241.00690766
59Arachidonic acid metabolism_Homo sapiens_hsa005900.96719307
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94332097
61Type II diabetes mellitus_Homo sapiens_hsa049300.92877866
62Butanoate metabolism_Homo sapiens_hsa006500.92822882
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.90972235
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90079768
65Thyroid hormone synthesis_Homo sapiens_hsa049180.89708486
66Rheumatoid arthritis_Homo sapiens_hsa053230.89648471
67VEGF signaling pathway_Homo sapiens_hsa043700.89155044
68Chemical carcinogenesis_Homo sapiens_hsa052040.88519262
69Fatty acid biosynthesis_Homo sapiens_hsa000610.84313773
70Tryptophan metabolism_Homo sapiens_hsa003800.83896077
71Inositol phosphate metabolism_Homo sapiens_hsa005620.83672631
72Platelet activation_Homo sapiens_hsa046110.83627015
73Hedgehog signaling pathway_Homo sapiens_hsa043400.83402054
74Nitrogen metabolism_Homo sapiens_hsa009100.82785632
75Adherens junction_Homo sapiens_hsa045200.80347056
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79955923
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78336392
78GnRH signaling pathway_Homo sapiens_hsa049120.77500403
79Retinol metabolism_Homo sapiens_hsa008300.77128454
80Collecting duct acid secretion_Homo sapiens_hsa049660.73477694
81Alzheimers disease_Homo sapiens_hsa050100.71272082
82Peroxisome_Homo sapiens_hsa041460.67564534
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67136522
84Arginine and proline metabolism_Homo sapiens_hsa003300.66486193
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65896680
86Tight junction_Homo sapiens_hsa045300.64659719
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64603974
88Morphine addiction_Homo sapiens_hsa050320.64257910
89Caffeine metabolism_Homo sapiens_hsa002320.63245381
90Fatty acid elongation_Homo sapiens_hsa000620.62908164
91Salmonella infection_Homo sapiens_hsa051320.62805888
92Tuberculosis_Homo sapiens_hsa051520.62642743
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62491676
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61214176
95Oxidative phosphorylation_Homo sapiens_hsa001900.60788386
96Linoleic acid metabolism_Homo sapiens_hsa005910.60289194
97Vitamin B6 metabolism_Homo sapiens_hsa007500.60027584
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59767754
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.58801977
100cAMP signaling pathway_Homo sapiens_hsa040240.58608782
101Arginine biosynthesis_Homo sapiens_hsa002200.58183551
102Ribosome_Homo sapiens_hsa030100.57579609
103Hippo signaling pathway_Homo sapiens_hsa043900.57560539
104Gastric acid secretion_Homo sapiens_hsa049710.57234763
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.57146499
106Histidine metabolism_Homo sapiens_hsa003400.56013186
107Sphingolipid metabolism_Homo sapiens_hsa006000.54892929
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54558425
109Autoimmune thyroid disease_Homo sapiens_hsa053200.54502338
110Protein digestion and absorption_Homo sapiens_hsa049740.54353861
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.54202901
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.51964328
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50577132
114Circadian entrainment_Homo sapiens_hsa047130.49946628
115Calcium signaling pathway_Homo sapiens_hsa040200.49863702
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49831043
117Glucagon signaling pathway_Homo sapiens_hsa049220.49442916
118Prostate cancer_Homo sapiens_hsa052150.48177551
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47906032
120Wnt signaling pathway_Homo sapiens_hsa043100.47844074
121Focal adhesion_Homo sapiens_hsa045100.47559032
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47402906
123Influenza A_Homo sapiens_hsa051640.47059633
124MAPK signaling pathway_Homo sapiens_hsa040100.46716534
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46102497
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45689691
127Ovarian steroidogenesis_Homo sapiens_hsa049130.45534886
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44802051
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44384171
130TGF-beta signaling pathway_Homo sapiens_hsa043500.43685581
131GABAergic synapse_Homo sapiens_hsa047270.43679973
132TNF signaling pathway_Homo sapiens_hsa046680.43548761
133ECM-receptor interaction_Homo sapiens_hsa045120.43111499
134Insulin resistance_Homo sapiens_hsa049310.41792034
135Nicotine addiction_Homo sapiens_hsa050330.41335600
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.40996216
137Glutamatergic synapse_Homo sapiens_hsa047240.40857385
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40616950
139Homologous recombination_Homo sapiens_hsa034400.40320698
140Toxoplasmosis_Homo sapiens_hsa051450.40163999
141Dilated cardiomyopathy_Homo sapiens_hsa054140.39900293
142Pyruvate metabolism_Homo sapiens_hsa006200.39889764
143Cocaine addiction_Homo sapiens_hsa050300.39715990
144Estrogen signaling pathway_Homo sapiens_hsa049150.38997683
145Hepatitis C_Homo sapiens_hsa051600.37198937
146Starch and sucrose metabolism_Homo sapiens_hsa005000.36642168
147Pancreatic secretion_Homo sapiens_hsa049720.36203586
148Cholinergic synapse_Homo sapiens_hsa047250.35898691
149Ras signaling pathway_Homo sapiens_hsa040140.35725858
150Fanconi anemia pathway_Homo sapiens_hsa034600.35177819
151Prolactin signaling pathway_Homo sapiens_hsa049170.32508842
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32300897
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31623793
154Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31185599

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