PASK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)6.70896672
2negative thymic T cell selection (GO:0045060)6.63957123
3tolerance induction (GO:0002507)6.49996958
4positive regulation of gamma-delta T cell activation (GO:0046645)6.04134124
5thymic T cell selection (GO:0045061)5.62691289
6regulation of gamma-delta T cell differentiation (GO:0045586)5.41792708
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.28220228
8nuclear pore complex assembly (GO:0051292)5.05439377
9DNA replication initiation (GO:0006270)5.04318399
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04051735
11negative regulation of cell killing (GO:0031342)5.04051735
12nuclear pore organization (GO:0006999)5.02726026
13regulation of gamma-delta T cell activation (GO:0046643)4.96960306
14DNA strand elongation involved in DNA replication (GO:0006271)4.95130685
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.93547617
16T cell selection (GO:0045058)4.93276113
17positive thymic T cell selection (GO:0045059)4.90730206
18positive T cell selection (GO:0043368)4.86345044
19DNA replication-dependent nucleosome organization (GO:0034723)4.75252611
20DNA replication-dependent nucleosome assembly (GO:0006335)4.75252611
21DNA strand elongation (GO:0022616)4.74961316
22histone H3-K36 demethylation (GO:0070544)4.62965321
23telomere maintenance via semi-conservative replication (GO:0032201)4.62810795
24DNA unwinding involved in DNA replication (GO:0006268)4.61932427
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.53598668
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47402550
27piRNA metabolic process (GO:0034587)4.36370907
28mitotic sister chromatid cohesion (GO:0007064)4.33568949
29T cell migration (GO:0072678)4.31110483
30telomere maintenance via recombination (GO:0000722)4.26374100
31regulation of B cell receptor signaling pathway (GO:0050855)4.22048896
32DNA replication checkpoint (GO:0000076)4.19712514
33mitotic recombination (GO:0006312)4.17447563
34regulation of isotype switching to IgG isotypes (GO:0048302)4.16924928
35protein localization to kinetochore (GO:0034501)4.15729661
36antigen processing and presentation of endogenous antigen (GO:0019883)4.01926898
37protein localization to chromosome, centromeric region (GO:0071459)4.01258084
38cilium or flagellum-dependent cell motility (GO:0001539)4.00241397
39translesion synthesis (GO:0019985)3.98341738
40pore complex assembly (GO:0046931)3.89705970
41response to interleukin-15 (GO:0070672)3.88420414
42chromatin remodeling at centromere (GO:0031055)3.84508321
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.82296480
44positive regulation of humoral immune response (GO:0002922)3.78046910
45microtubule depolymerization (GO:0007019)3.77503662
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77151399
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76614042
48telomere maintenance via telomere lengthening (GO:0010833)3.76595455
49regulation of alpha-beta T cell proliferation (GO:0046640)3.74963737
50positive regulation of alpha-beta T cell proliferation (GO:0046641)3.72796593
51kinetochore organization (GO:0051383)3.71435090
52cellular response to interleukin-15 (GO:0071350)3.71319639
53heterochromatin organization (GO:0070828)3.69302354
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.68264738
55viral transcription (GO:0019083)3.67950943
56intra-S DNA damage checkpoint (GO:0031573)3.65056131
57regulation of interleukin-2 biosynthetic process (GO:0045076)3.63765220
58mitotic sister chromatid segregation (GO:0000070)3.63638032
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.63605247
60positive regulation of granulocyte differentiation (GO:0030854)3.61208653
61mitotic nuclear envelope disassembly (GO:0007077)3.58014721
62chromosome organization involved in meiosis (GO:0070192)3.56075775
63B cell receptor signaling pathway (GO:0050853)3.55607388
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.54334239
65DNA synthesis involved in DNA repair (GO:0000731)3.54063839
66mitotic chromosome condensation (GO:0007076)3.53173776
67histone H2A acetylation (GO:0043968)3.52837532
68interferon-gamma production (GO:0032609)3.51855342
69mitotic metaphase plate congression (GO:0007080)3.50527765
70synaptonemal complex assembly (GO:0007130)3.49295324
71DNA geometric change (GO:0032392)3.47397571
72histone exchange (GO:0043486)3.47212303
73mismatch repair (GO:0006298)3.46562951
74sister chromatid segregation (GO:0000819)3.45940722
75meiotic chromosome segregation (GO:0045132)3.44565102
76DNA duplex unwinding (GO:0032508)3.44529224
77male meiosis (GO:0007140)3.41929669
78translational termination (GO:0006415)3.41823254
79telomere organization (GO:0032200)3.41290210
80T cell receptor signaling pathway (GO:0050852)3.41130398
81CENP-A containing nucleosome assembly (GO:0034080)3.40418022
82regulation of histone H3-K9 methylation (GO:0051570)3.40070104
83DNA replication-independent nucleosome organization (GO:0034724)3.40006427
84DNA replication-independent nucleosome assembly (GO:0006336)3.40006427
85binding of sperm to zona pellucida (GO:0007339)3.39689218
86regulation of NFAT protein import into nucleus (GO:0051532)3.39169441
87V(D)J recombination (GO:0033151)3.37821308
88NIK/NF-kappaB signaling (GO:0038061)3.34705192
89synaptonemal complex organization (GO:0070193)3.32502676
90regulation of B cell differentiation (GO:0045577)3.32481617
91positive regulation of B cell differentiation (GO:0045579)3.31519883
92sperm-egg recognition (GO:0035036)3.31035712
93antigen receptor-mediated signaling pathway (GO:0050851)3.29131381
94DNA methylation involved in gamete generation (GO:0043046)3.29043257
95negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.29026923
96telomere maintenance (GO:0000723)3.27794398
97nuclear envelope disassembly (GO:0051081)3.27572057
98membrane disassembly (GO:0030397)3.27572057
99Peyers patch development (GO:0048541)3.25761373
100mucosal-associated lymphoid tissue development (GO:0048537)3.25761373
101ribosomal small subunit assembly (GO:0000028)3.25225105
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24122076
103metaphase plate congression (GO:0051310)3.23264118
104leukocyte aggregation (GO:0070486)3.22657258
105attachment of spindle microtubules to kinetochore (GO:0008608)3.22642190
106chromatin assembly (GO:0031497)3.22255451
107regulation of DNA endoreduplication (GO:0032875)3.21897311
108chromosome condensation (GO:0030261)3.21391071
109establishment of integrated proviral latency (GO:0075713)3.21249220
110sister chromatid cohesion (GO:0007062)3.20589339
111DNA packaging (GO:0006323)3.20126429
112DNA conformation change (GO:0071103)3.18582915
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.17790267
114regulation of double-strand break repair via homologous recombination (GO:0010569)3.16794337
115chromatin assembly or disassembly (GO:0006333)3.16788474
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.16671072
117regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.16616847
118B cell homeostasis (GO:0001782)3.16569474
119regulation of centriole replication (GO:0046599)3.14860177
120axonemal dynein complex assembly (GO:0070286)3.14705989
121nucleobase biosynthetic process (GO:0046112)3.14379171
122postreplication repair (GO:0006301)3.13304179
123negative regulation of T cell mediated immunity (GO:0002710)3.12825422
124T cell costimulation (GO:0031295)3.11407035
125regulation of centrosome cycle (GO:0046605)3.11179151
126kinetochore assembly (GO:0051382)3.10369553
127reciprocal meiotic recombination (GO:0007131)3.09584363
128reciprocal DNA recombination (GO:0035825)3.09584363
129T cell homeostasis (GO:0043029)3.08931749
130positive regulation of interleukin-2 production (GO:0032743)3.07981238
131lymphocyte costimulation (GO:0031294)3.07807151
132dosage compensation (GO:0007549)3.07449428
133alpha-beta T cell differentiation (GO:0046632)3.06666691
134chromosome organization (GO:0051276)3.06417580
135lymphocyte homeostasis (GO:0002260)3.06354132
136meiotic nuclear division (GO:0007126)3.06188869
137regulation of regulatory T cell differentiation (GO:0045589)3.04251759
138IMP biosynthetic process (GO:0006188)3.04168604
139chromosome segregation (GO:0007059)3.04067215
140positive regulation of isotype switching (GO:0045830)3.03743621
141fusion of sperm to egg plasma membrane (GO:0007342)3.02917872
142base-excision repair (GO:0006284)3.02479265
143histone H4-K16 acetylation (GO:0043984)3.01062215
144protein localization to chromosome (GO:0034502)3.00635934
145negative regulation of histone methylation (GO:0031061)3.00384506
146negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00080365
147protein K6-linked ubiquitination (GO:0085020)2.99723237
148natural killer cell differentiation (GO:0001779)2.99019058
149regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.98679388
150histone H4-K12 acetylation (GO:0043983)2.98592838
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98420549
152regulation of sister chromatid cohesion (GO:0007063)2.97816203
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.97801693
154regulation of chromosome segregation (GO:0051983)2.97785165
155T cell differentiation (GO:0030217)2.97780555
156ribosomal small subunit biogenesis (GO:0042274)2.97560312
157resolution of meiotic recombination intermediates (GO:0000712)2.97381760
158somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95542422
159somatic hypermutation of immunoglobulin genes (GO:0016446)2.95542422
160ATP-dependent chromatin remodeling (GO:0043044)2.95407058
161mast cell activation (GO:0045576)2.94298441
162cellular response to interleukin-4 (GO:0071353)2.93948519
163regulation of natural killer cell mediated immunity (GO:0002715)2.93338511
164regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93338511
165translational elongation (GO:0006414)2.91256909
166DNA ligation (GO:0006266)2.90454344
167cell-cell recognition (GO:0009988)2.89973687
168synapsis (GO:0007129)2.89708127
169lymphocyte migration (GO:0072676)2.88196920
170negative regulation of lymphocyte mediated immunity (GO:0002707)2.87027034
171nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86694524
172negative regulation of protein oligomerization (GO:0032460)2.83711101
173antigen processing and presentation via MHC class Ib (GO:0002475)2.82741526
174positive regulation of T cell differentiation in thymus (GO:0033089)2.81470880
175cellular protein complex disassembly (GO:0043624)2.80566853
176histone lysine demethylation (GO:0070076)2.77395732
177alpha-beta T cell activation (GO:0046631)2.77384151
178regulation of T cell tolerance induction (GO:0002664)2.72539080
179histone H3-K4 trimethylation (GO:0080182)2.71216852
180regulation of interleukin-4 production (GO:0032673)2.71093417
181positive regulation of mRNA catabolic process (GO:0061014)2.70601838
182regulation of histone H3-K27 methylation (GO:0061085)2.69308194
183histone H4-K5 acetylation (GO:0043981)2.69087091
184histone H4-K8 acetylation (GO:0043982)2.69087091
185leukocyte homeostasis (GO:0001776)2.68805290
186positive regulation of interleukin-4 production (GO:0032753)2.68657971
187viral life cycle (GO:0019058)2.67365235
188regulation of chromatin binding (GO:0035561)2.64399133
189mast cell degranulation (GO:0043303)2.64267365
190mast cell activation involved in immune response (GO:0002279)2.64267365
191regulation of alpha-beta T cell activation (GO:0046634)2.63732704
192histone demethylation (GO:0016577)2.63447318
193positive regulation of immunoglobulin mediated immune response (GO:0002891)2.62631268
194positive regulation of B cell mediated immunity (GO:0002714)2.62631268
195maturation of 5.8S rRNA (GO:0000460)2.62457291
196myeloid dendritic cell differentiation (GO:0043011)2.61954283
197positive regulation of natural killer cell mediated immunity (GO:0002717)2.60737560
198protein complex disassembly (GO:0043241)2.60222182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.83569161
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.76097789
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.75882914
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.61721361
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.92878285
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29315073
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.22604750
8MAF_26560356_Chip-Seq_TH1_Human2.83868790
9MYB_26560356_Chip-Seq_TH2_Human2.80076408
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.78395379
11VDR_21846776_ChIP-Seq_THP-1_Human2.73911193
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65582219
13MYB_26560356_Chip-Seq_TH1_Human2.65563516
14UTX_26944678_Chip-Seq_JUKART_Human2.58702344
15RUNX_20019798_ChIP-Seq_JUKART_Human2.58124213
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52367588
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43874717
18MAF_26560356_Chip-Seq_TH2_Human2.39432811
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34060970
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.30927131
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30463491
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.30109995
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.30073519
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.26802844
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.22728136
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22416689
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21656714
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.18164372
29AR_21909140_ChIP-Seq_LNCAP_Human2.15418503
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08387314
31TCF7_22412390_ChIP-Seq_EML_Mouse2.05806051
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05649446
33* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02334390
34E2F7_22180533_ChIP-Seq_HELA_Human13.1357254
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.98794098
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95490464
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95442373
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.92263220
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89259396
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87709559
41* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87545853
42XRN2_22483619_ChIP-Seq_HELA_Human1.87198518
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.87015914
44* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84672637
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84296693
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83859633
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79628575
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78608265
49GATA3_27048872_Chip-Seq_THYMUS_Human1.78270585
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.73968282
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72425339
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70889009
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69103377
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68599665
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68096249
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68059655
57KDM2B_26808549_Chip-Seq_DND41_Human1.65807123
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64988382
59* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62670525
60TTF2_22483619_ChIP-Seq_HELA_Human1.61525106
61SCL_19346495_ChIP-Seq_HPC-7_Human1.60118646
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58986386
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.54786899
64DCP1A_22483619_ChIP-Seq_HELA_Human1.54481595
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52703156
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.50163740
67SPI1_23547873_ChIP-Seq_NB4_Human1.50161673
68VDR_24763502_ChIP-Seq_THP-1_Human1.50155046
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49725950
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47399387
71FOXP3_21729870_ChIP-Seq_TREG_Human1.46429207
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46266921
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45489780
74* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45342525
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42701330
76MYC_22102868_ChIP-Seq_BL_Human1.42500567
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40177231
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.40171221
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39587971
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38743161
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.37257506
82* VDR_23849224_ChIP-Seq_CD4+_Human1.36431286
83* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34654161
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33733962
85CIITA_25753668_ChIP-Seq_RAJI_Human1.33326226
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.29665726
87* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29397955
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29053872
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.26296141
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21760533
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19007652
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18623145
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17449552
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16516908
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15510567
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14528656
97* GABP_19822575_ChIP-Seq_HepG2_Human1.13316745
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10346580
99GATA3_26560356_Chip-Seq_TH2_Human1.09736201
100GABP_17652178_ChIP-ChIP_JURKAT_Human1.09655152
101P68_20966046_ChIP-Seq_HELA_Human1.09427650
102KDM5A_27292631_Chip-Seq_BREAST_Human1.09420742
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08842781
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08448987
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.06670813
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06577919
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06577919
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06577919
109* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06343226
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05815194
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05070347
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04571327
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02281589
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01576336
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01395947
116ELK1_19687146_ChIP-ChIP_HELA_Human1.00942642
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00752674
118NCOR1_26117541_ChIP-Seq_K562_Human1.00677565
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00633731
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98120884
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97765907
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97258056
123BCOR_27268052_Chip-Seq_Bcells_Human0.96667860
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96177591
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96004463
126LXR_22292898_ChIP-Seq_THP-1_Human0.94490332
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93822934
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93396213
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.93078679
130SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.92651189
131ELK3_25401928_ChIP-Seq_HUVEC_Human0.92405171
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92146456
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.91786053
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90627601
135RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90566004
136TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87523646
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87195403
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86706160
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85054595
140* SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84482693
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84161024
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83192609
143TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81348897
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80265925
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77257316
146SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73607888
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.73520155
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73313049
149HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73230035
150SRF_21415370_ChIP-Seq_HL-1_Mouse0.73033338
151* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.72220863
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.71377873
153MYC_18940864_ChIP-ChIP_HL60_Human0.71079873
154SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.70380529
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.70356608
156* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.68734718
157POU5F1_16153702_ChIP-ChIP_HESCs_Human0.67768517
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65536241
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.65163668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.11679428
2MP0002653_abnormal_ependyma_morphology4.41429418
3MP0010094_abnormal_chromosome_stability4.39224337
4MP0008057_abnormal_DNA_replication4.31783158
5MP0005671_abnormal_response_to4.06853568
6MP0003111_abnormal_nucleus_morphology3.77797067
7MP0001873_stomach_inflammation3.64616182
8MP0008877_abnormal_DNA_methylation3.46098568
9MP0005410_abnormal_fertilization3.42087238
10MP0001800_abnormal_humoral_immune3.18854122
11MP0008058_abnormal_DNA_repair3.16897270
12MP0003693_abnormal_embryo_hatching3.15284879
13MP0003077_abnormal_cell_cycle3.15271165
14MP0004957_abnormal_blastocyst_morpholog3.09959609
15MP0009333_abnormal_splenocyte_physiolog3.04550435
16MP0000685_abnormal_immune_system2.99425645
17MP0002254_reproductive_system_inflammat2.87829827
18MP0003123_paternal_imprinting2.86327492
19MP0008007_abnormal_cellular_replicative2.64387141
20MP0002398_abnormal_bone_marrow2.56389481
21MP0003121_genomic_imprinting2.53005426
22MP0010030_abnormal_orbit_morphology2.51309463
23MP0005000_abnormal_immune_tolerance2.47535496
24MP0001348_abnormal_lacrimal_gland2.44862141
25MP0003436_decreased_susceptibility_to2.37813699
26MP0005387_immune_system_phenotype2.35826581
27MP0001790_abnormal_immune_system2.35826581
28MP0001835_abnormal_antigen_presentation2.34308099
29MP0002420_abnormal_adaptive_immunity2.34231508
30MP0002723_abnormal_immune_serum2.33159944
31MP0001819_abnormal_immune_cell2.30489786
32MP0002210_abnormal_sex_determination2.23094387
33MP0001929_abnormal_gametogenesis2.21995528
34MP0002452_abnormal_antigen_presenting2.20836041
35MP0000716_abnormal_immune_system2.15301164
36MP0005310_abnormal_salivary_gland2.12624316
37MP0002009_preneoplasia2.09677052
38MP0002722_abnormal_immune_system2.08493925
39MP0000689_abnormal_spleen_morphology2.07442156
40MP0002405_respiratory_system_inflammati2.01776054
41MP0003866_abnormal_defecation1.98610596
42MP0010155_abnormal_intestine_physiology1.98333421
43MP0003698_abnormal_male_reproductive1.98211913
44MP0008932_abnormal_embryonic_tissue1.95058598
45MP0001730_embryonic_growth_arrest1.93754072
46MP0003786_premature_aging1.92396758
47MP0001346_abnormal_lacrimal_gland1.88901822
48MP0001915_intracranial_hemorrhage1.84496563
49MP0001145_abnormal_male_reproductive1.82861305
50MP0000350_abnormal_cell_proliferation1.81872593
51MP0002166_altered_tumor_susceptibility1.78408212
52MP0002429_abnormal_blood_cell1.77908645
53MP0003136_yellow_coat_color1.77444527
54MP0003300_gastrointestinal_ulcer1.75593596
55MP0005025_abnormal_response_to1.75239468
56MP0002396_abnormal_hematopoietic_system1.73203009
57MP0002085_abnormal_embryonic_tissue1.69227758
58MP0004197_abnormal_fetal_growth/weight/1.67457392
59MP0010307_abnormal_tumor_latency1.65887645
60MP0000653_abnormal_sex_gland1.63166054
61MP0001672_abnormal_embryogenesis/_devel1.59055700
62MP0005380_embryogenesis_phenotype1.59055700
63MP0002138_abnormal_hepatobiliary_system1.54281344
64MP0002160_abnormal_reproductive_system1.48934489
65MP0006082_CNS_inflammation1.47070475
66MP0000566_synostosis1.47028337
67MP0001697_abnormal_embryo_size1.46158775
68MP0000537_abnormal_urethra_morphology1.45831221
69MP0008995_early_reproductive_senescence1.41975669
70MP0004947_skin_inflammation1.41425125
71MP0002277_abnormal_respiratory_mucosa1.40994924
72MP0002088_abnormal_embryonic_growth/wei1.40803888
73MP0003984_embryonic_growth_retardation1.40755563
74MP0005645_abnormal_hypothalamus_physiol1.39191863
75MP0003315_abnormal_perineum_morphology1.36416846
76MP0003119_abnormal_digestive_system1.35177967
77MP0002084_abnormal_developmental_patter1.35100322
78MP0001529_abnormal_vocalization1.33390952
79MP0005075_abnormal_melanosome_morpholog1.32971636
80MP0009785_altered_susceptibility_to1.30890902
81MP0003122_maternal_imprinting1.30299814
82MP0002080_prenatal_lethality1.28139036
83MP0002161_abnormal_fertility/fecundity1.24843851
84MP0002006_tumorigenesis1.24506601
85MP0005076_abnormal_cell_differentiation1.23824762
86MP0002419_abnormal_innate_immunity1.23360546
87MP0001727_abnormal_embryo_implantation1.21685298
88MP0000313_abnormal_cell_death1.19474235
89MP0004808_abnormal_hematopoietic_stem1.18739650
90MP0003787_abnormal_imprinting1.18205139
91MP0002086_abnormal_extraembryonic_tissu1.17777646
92MP0003303_peritoneal_inflammation1.17204993
93MP0008789_abnormal_olfactory_epithelium1.17039799
94MP0002938_white_spotting1.16175555
95MP0002089_abnormal_postnatal_growth/wei1.15994372
96MP0001845_abnormal_inflammatory_respons1.12122041
97MP0003890_abnormal_embryonic-extraembry1.11731514
98MP0010352_gastrointestinal_tract_polyps1.10897215
99MP0003115_abnormal_respiratory_system1.08549361
100MP0009278_abnormal_bone_marrow1.07736333
101MP0003941_abnormal_skin_development1.05598041
102MP0002111_abnormal_tail_morphology1.04137184
103MP0001293_anophthalmia1.04108546
104MP0003861_abnormal_nervous_system1.03666762
105MP0000490_abnormal_crypts_of1.01123881
106MP0002163_abnormal_gland_morphology1.00970911
107MP0009703_decreased_birth_body1.00886847
108MP0001853_heart_inflammation1.00608541
109MP0005389_reproductive_system_phenotype1.00460775
110MP0003937_abnormal_limbs/digits/tail_de1.00137889
111MP0000428_abnormal_craniofacial_morphol0.97608864
112MP0003567_abnormal_fetal_cardiomyocyte0.97285254
113MP0001119_abnormal_female_reproductive0.96685992
114MP0000432_abnormal_head_morphology0.94717378
115MP0002148_abnormal_hypersensitivity_rea0.91909395
116MP0000049_abnormal_middle_ear0.91864938
117MP0001663_abnormal_digestive_system0.91760578
118MP0005394_taste/olfaction_phenotype0.90927107
119MP0005499_abnormal_olfactory_system0.90927107
120MP0002019_abnormal_tumor_incidence0.90192148
121MP0004381_abnormal_hair_follicle0.88911812
122MP0002933_joint_inflammation0.87729539
123MP0002233_abnormal_nose_morphology0.86783801
124MP0009672_abnormal_birth_weight0.85995476
125MP0002116_abnormal_craniofacial_bone0.85494055
126MP0000465_gastrointestinal_hemorrhage0.84002968
127MP0002822_catalepsy0.83096010
128MP0004133_heterotaxia0.83047353
129MP0005187_abnormal_penis_morphology0.81419728
130MP0002132_abnormal_respiratory_system0.78547561
131MP0004185_abnormal_adipocyte_glucose0.78319323
132MP0001919_abnormal_reproductive_system0.78084145
133MP0005451_abnormal_body_composition0.77549669
134MP0001851_eye_inflammation0.77292186
135MP0000703_abnormal_thymus_morphology0.77147384
136MP0003935_abnormal_craniofacial_develop0.76462867
137MP0002092_abnormal_eye_morphology0.72912283
138MP0004134_abnormal_chest_morphology0.71862545
139MP0001286_abnormal_eye_development0.71073168
140MP0002282_abnormal_trachea_morphology0.69718174
141MP0003566_abnormal_cell_adhesion0.69628724
142MP0003755_abnormal_palate_morphology0.68924139
143MP0005379_endocrine/exocrine_gland_phen0.68832181
144MP0000647_abnormal_sebaceous_gland0.68682763
145MP0003936_abnormal_reproductive_system0.68661063
146MP0008260_abnormal_autophagy0.68094428
147MP0000477_abnormal_intestine_morphology0.67721365
148MP0008961_abnormal_basal_metabolism0.67379315
149MP0003718_maternal_effect0.67224454
150MP0009053_abnormal_anal_canal0.66550233
151MP0006292_abnormal_olfactory_placode0.64375105
152MP0003385_abnormal_body_wall0.62587139
153MP0002114_abnormal_axial_skeleton0.62570857
154MP0000858_altered_metastatic_potential0.61559026
155MP0003878_abnormal_ear_physiology0.60978467
156MP0005377_hearing/vestibular/ear_phenot0.60978467
157MP0003699_abnormal_female_reproductive0.60715058
158* MP0002693_abnormal_pancreas_physiology0.59780063
159MP0005391_vision/eye_phenotype0.58294225
160MP0008469_abnormal_protein_level0.55609538
161MP0003724_increased_susceptibility_to0.49715022
162MP0005381_digestive/alimentary_phenotyp0.49695126

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.45186466
2Panhypogammaglobulinemia (HP:0003139)4.39384518
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.32317689
4Agammaglobulinemia (HP:0004432)4.22171871
5T lymphocytopenia (HP:0005403)4.19428135
6Abnormality of T cell number (HP:0011839)4.18999036
7IgG deficiency (HP:0004315)4.13675455
8Lymphopenia (HP:0001888)4.03668359
9Abnormality of cells of the lymphoid lineage (HP:0012140)3.98495777
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.98200694
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.95377756
12Abnormality of T cells (HP:0002843)3.94773957
13Recurrent sinusitis (HP:0011108)3.93722373
14Gastrointestinal stroma tumor (HP:0100723)3.90380465
15Chromsome breakage (HP:0040012)3.88893578
16Selective tooth agenesis (HP:0001592)3.84757341
17Basal cell carcinoma (HP:0002671)3.73320516
18Abnormality of the ileum (HP:0001549)3.61855336
19Abnormal number of incisors (HP:0011064)3.58805384
20Pustule (HP:0200039)3.57196719
21Severe combined immunodeficiency (HP:0004430)3.56496999
22Autoimmune hemolytic anemia (HP:0001890)3.55144307
23Birth length less than 3rd percentile (HP:0003561)3.53382977
24Stomatitis (HP:0010280)3.53376389
25Recurrent bronchitis (HP:0002837)3.49555697
26Abnormality of the fingertips (HP:0001211)3.47081899
27Eczematoid dermatitis (HP:0000976)3.46706525
28Abnormality of T cell physiology (HP:0011840)3.46566461
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.45377132
30Absent/shortened dynein arms (HP:0200106)3.45377132
31Large earlobe (HP:0009748)3.40454240
32IgA deficiency (HP:0002720)3.39564808
33Recurrent fungal infections (HP:0002841)3.39348839
34Recurrent viral infections (HP:0004429)3.39136407
35Meckel diverticulum (HP:0002245)3.33818676
36Volvulus (HP:0002580)3.28329124
37Abnormality of chromosome stability (HP:0003220)3.26752606
38Aplasia/Hypoplasia of the uvula (HP:0010293)3.24815242
39Chronic mucocutaneous candidiasis (HP:0002728)3.22632455
40Recurrent cutaneous fungal infections (HP:0011370)3.22632455
41Combined immunodeficiency (HP:0005387)3.21967940
42Increased IgM level (HP:0003496)3.18125293
43Nasal polyposis (HP:0100582)3.17872910
44Chronic diarrhea (HP:0002028)3.15285361
45Short 4th metacarpal (HP:0010044)3.10535929
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10535929
47Elevated erythrocyte sedimentation rate (HP:0003565)3.09065590
48Impulsivity (HP:0100710)3.08043100
49Lymphoma (HP:0002665)3.05148855
50Bronchiectasis (HP:0002110)3.05133909
51Esophageal atresia (HP:0002032)3.04814998
52Abnormality of the preputium (HP:0100587)3.04746260
5311 pairs of ribs (HP:0000878)3.00153923
54Nephroblastoma (Wilms tumor) (HP:0002667)2.99476534
55Vasculitis (HP:0002633)2.94493712
56Abnormality of B cell number (HP:0010975)2.92629821
57Abnormality of the carotid arteries (HP:0005344)2.91893899
58Gastrointestinal atresia (HP:0002589)2.90177928
59Recurrent otitis media (HP:0000403)2.90070179
60Supernumerary spleens (HP:0009799)2.89720435
61Abnormal respiratory epithelium morphology (HP:0012253)2.88809821
62Abnormal respiratory motile cilium morphology (HP:0005938)2.88809821
63Bronchitis (HP:0012387)2.88171848
64Meningitis (HP:0001287)2.86836239
65Medulloblastoma (HP:0002885)2.84453455
66Colitis (HP:0002583)2.80502051
67Embryonal renal neoplasm (HP:0011794)2.78192496
68Proximal placement of thumb (HP:0009623)2.76779976
69Gastrointestinal inflammation (HP:0004386)2.75940396
70Increased nuchal translucency (HP:0010880)2.75402525
71Ectopic kidney (HP:0000086)2.74105189
72Stomach cancer (HP:0012126)2.70645722
73Papilloma (HP:0012740)2.70106957
74Verrucae (HP:0200043)2.70106957
75Skull defect (HP:0001362)2.69857895
76Autoimmune thrombocytopenia (HP:0001973)2.69076163
77Chronic otitis media (HP:0000389)2.66429643
78Increased IgE level (HP:0003212)2.64203636
79Inflammation of the large intestine (HP:0002037)2.62981178
80Deviation of the thumb (HP:0009603)2.61916520
81Abnormal respiratory motile cilium physiology (HP:0012261)2.59066806
82Trigonocephaly (HP:0000243)2.57507410
83Abnormal lung lobation (HP:0002101)2.57294892
84Duodenal stenosis (HP:0100867)2.57269184
85Small intestinal stenosis (HP:0012848)2.57269184
86Degeneration of anterior horn cells (HP:0002398)2.56730262
87Abnormality of the anterior horn cell (HP:0006802)2.56730262
88Patellar aplasia (HP:0006443)2.52114110
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49846599
90Intestinal atresia (HP:0011100)2.49386329
91Breast hypoplasia (HP:0003187)2.49220196
92Abnormality of cells of the erythroid lineage (HP:0012130)2.46463663
93Ependymoma (HP:0002888)2.41243225
94Hypoplasia of the radius (HP:0002984)2.41115868
95Chronic bronchitis (HP:0004469)2.39053979
96Absent forearm bone (HP:0003953)2.37848138
97Aplasia involving forearm bones (HP:0009822)2.37848138
98Encephalitis (HP:0002383)2.36688563
99Granulocytopenia (HP:0001913)2.36632209
100Abnormality of the labia minora (HP:0012880)2.34549273
101Abnormality of abdominal situs (HP:0011620)2.33582005
102Abdominal situs inversus (HP:0003363)2.33582005
103Absent radius (HP:0003974)2.32715724
104Clubbing of toes (HP:0100760)2.30730636
105Aplasia/Hypoplasia of the patella (HP:0006498)2.30576261
106Flat occiput (HP:0005469)2.30297004
107Abnormal number of erythroid precursors (HP:0012131)2.29567200
108Abnormality of eosinophils (HP:0001879)2.27649082
109Short thumb (HP:0009778)2.27490256
110Chronic sinusitis (HP:0011109)2.25629544
111Absent thumb (HP:0009777)2.23409468
112Sloping forehead (HP:0000340)2.20403143
113Papilledema (HP:0001085)2.20140677
114Tracheoesophageal fistula (HP:0002575)2.19221170
115Bone marrow hypocellularity (HP:0005528)2.18348767
116Seborrheic dermatitis (HP:0001051)2.16334281
117Asplenia (HP:0001746)2.15815738
118Abnormality of the duodenum (HP:0002246)2.15775745
119Emphysema (HP:0002097)2.14886935
120Abnormality of the nasal mucosa (HP:0000433)2.14808915
121Abnormality of homocysteine metabolism (HP:0010919)2.11984145
122Homocystinuria (HP:0002156)2.11984145
123Neoplasm of the oral cavity (HP:0100649)2.11949442
124Abnormal ciliary motility (HP:0012262)2.10623981
125Mediastinal lymphadenopathy (HP:0100721)2.10396791
126Abnormality of DNA repair (HP:0003254)2.09997143
127Myelodysplasia (HP:0002863)2.09524021
128Rhinitis (HP:0012384)2.08195300
129Triphalangeal thumb (HP:0001199)2.08169146
130Duplicated collecting system (HP:0000081)2.07933349
131B lymphocytopenia (HP:0010976)2.06615627
132Glioma (HP:0009733)2.03910469
133Hypochromic anemia (HP:0001931)2.02815634
134Atresia of the external auditory canal (HP:0000413)2.02427878
135Abnormality of the incisor (HP:0000676)2.02070527
136Leukopenia (HP:0001882)2.00024913
137Pseudobulbar signs (HP:0002200)1.99875687
138Abnormality of the 4th metacarpal (HP:0010012)1.99829662
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.99140035
140Missing ribs (HP:0000921)1.99057279
141Duplication of thumb phalanx (HP:0009942)1.98941615
142Colon cancer (HP:0003003)1.97618803
143Mesomelia (HP:0003027)1.97579496
144Neoplasm of the pancreas (HP:0002894)1.97188577
145Viral hepatitis (HP:0006562)1.97167265
146Broad alveolar ridges (HP:0000187)1.94919899
147Preaxial hand polydactyly (HP:0001177)1.94433850
148Eosinophilia (HP:0001880)1.93448520
149Abnormality of the renal collecting system (HP:0004742)1.92566602
150Abnormal spermatogenesis (HP:0008669)1.91710552
151Short nail (HP:0001799)1.91595581
152Recurrent skin infections (HP:0001581)1.91069549
153Optic nerve coloboma (HP:0000588)1.90965075
154Pallor (HP:0000980)1.90868121
155Agnosia (HP:0010524)1.89983780
156Recurrent bacterial skin infections (HP:0005406)1.89215134
157Restrictive lung disease (HP:0002091)1.88971269
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87886033
159Absent epiphyses (HP:0010577)1.87886033
160Deep palmar crease (HP:0006191)1.87443883
161Deep philtrum (HP:0002002)1.87357468
162High pitched voice (HP:0001620)1.86787697
163Abnormality of the columella (HP:0009929)1.86708652
164Hepatitis (HP:0012115)1.85801536
165Neutropenia (HP:0001875)1.85718495
166Leukocytosis (HP:0001974)1.85713941
167Obstructive sleep apnea (HP:0002870)1.85166421
168High anterior hairline (HP:0009890)1.84437406
169Fibular hypoplasia (HP:0003038)1.84228772
170Cellulitis (HP:0100658)1.83796817
171Deformed sella turcica (HP:0002681)1.83589764
172Chronic hepatic failure (HP:0100626)1.82105898
173Teleangiectasia of the skin (HP:0100585)1.81829391
174Reticulocytopenia (HP:0001896)1.81765967
175Renovascular hypertension (HP:0100817)1.81013281
176Facial cleft (HP:0002006)1.80576865
177Slow saccadic eye movements (HP:0000514)1.80520154
178Renal duplication (HP:0000075)1.80499464
179Chronic obstructive pulmonary disease (HP:0006510)1.76873590
180Obstructive lung disease (HP:0006536)1.76873590
181Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75260307
182Choanal atresia (HP:0000453)1.74233175
183Cafe-au-lait spot (HP:0000957)1.73782665
184Dysphonia (HP:0001618)1.72734179
185Abnormality of the alveolar ridges (HP:0006477)1.70964378
186Trismus (HP:0000211)1.70410282
187Abnormality of the antihelix (HP:0009738)1.69462729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.92992209
2MAP4K14.80063290
3MAP3K134.09093861
4WEE14.08856492
5TXK3.27983723
6PRPF4B3.17618864
7NEK23.00715553
8PDK32.96392955
9PDK42.96392955
10MAP3K142.66025402
11ITK2.58431900
12TTK2.49951009
13SRPK12.43252833
14BRSK22.41971682
15SMG12.41238144
16SIK22.39597503
17RIPK42.36919614
18CDK122.36512381
19BUB12.33949268
20PAK42.20350418
21ATR2.15665543
22FGFR42.12716664
23TESK12.01879791
24PLK12.00204991
25TRIB31.99823453
26MKNK11.86384931
27* PASK1.85141646
28PDK21.78135800
29PKN21.78017585
30NLK1.75813189
31CHEK11.73842832
32CCNB11.71151264
33CHEK21.68690247
34BRSK11.66200379
35TLK11.65807284
36SIK31.65425801
37CLK11.64440650
38IKBKE1.56852923
39CDK71.55037005
40VRK11.53770523
41AURKB1.51163583
42JAK31.50149936
43MKNK21.49549720
44CDK41.49220900
45PLK31.48146190
46TYK21.46884867
47ICK1.46480546
48GRK61.45663652
49FLT31.43903850
50SCYL21.43472103
51ACVR1B1.37733326
52NEK61.37319079
53PLK41.37277304
54SYK1.37259384
55ZAK1.36975889
56TSSK61.32382194
57ERBB31.32250399
58LCK1.31649334
59CSK1.30121945
60MAP3K101.26696343
61TYRO31.21150102
62SIK11.20072341
63TEC1.19906655
64ZAP701.18626132
65MAP3K71.17019640
66FGFR31.15937895
67IKBKB1.15170389
68TNK21.14707393
69CAMKK21.13682664
70ATM1.10926057
71DYRK31.09560806
72BRD41.07448818
73STK41.06776200
74HCK1.05702944
75TESK21.02986498
76CHUK1.02286000
77EPHA21.00046420
78JAK10.97908801
79CDK20.97717436
80MARK30.97387581
81PRKCQ0.96761684
82EEF2K0.94828900
83LYN0.94554119
84FES0.91638769
85TGFBR10.90726716
86NEK10.87688708
87RPS6KB20.87506491
88FGR0.87177007
89CDK190.86190775
90BCR0.85580139
91EIF2AK10.81166710
92CDK10.79719566
93STK30.79018149
94MELK0.78391739
95PNCK0.76713456
96TBK10.76662191
97AURKA0.76591266
98STK38L0.75915892
99CSF1R0.75795960
100MAPK110.75314363
101MAPK150.75272859
102PRKD30.73160337
103MAP3K80.72836638
104TAOK30.68683356
105TAF10.67869929
106CDK80.67285743
107CSNK1D0.66082378
108YES10.63847878
109KSR10.63463036
110MAPK70.62329632
111STK100.61856501
112CSNK2A10.59776034
113MARK20.59382820
114CDK90.59144840
115FGFR20.55815657
116MAP2K20.55600869
117CDK60.55491902
118PIM10.55190879
119EIF2AK20.55186828
120CSNK2A20.55114925
121KDR0.55044153
122* CAMKK10.53665379
123RPS6KA40.53287997
124ERBB20.52699548
125HIPK20.51660562
126EIF2AK30.51053109
127PAK20.51053041
128LRRK20.47885177
129PAK10.46923626
130PDK10.46835694
131PRKDC0.46633177
132RPS6KL10.46302208
133RPS6KC10.46302208
134EPHB20.45525333
135MAPK140.45358255
136MTOR0.45046482
137JAK20.42124940
138TAOK20.41789119
139TAOK10.40462809
140UHMK10.39355648
141BLK0.39021096
142RPS6KA60.38429763
143MAPK130.38364755
144RPS6KA50.38357561
145CDC42BPA0.37971988
146PRKCH0.37589021
147AKT10.37529761
148GSK3B0.37428028
149FGFR10.36436615
150MAPK120.35743746
151IRAK10.35706937
152AKT30.35569919
153MAP3K110.33977094
154CSNK1E0.33793742
155CAMK1D0.32685937
156EPHB10.32272715
157MAP2K30.32054124
158STK110.31948489
159BTK0.31436334
160ALK0.29773106
161IRAK40.28606806
162PRKCI0.28002317
163BCKDK0.27868203
164RPS6KB10.26466678

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.63399650
2Mismatch repair_Homo sapiens_hsa034304.62795877
3Homologous recombination_Homo sapiens_hsa034403.95919409
4Base excision repair_Homo sapiens_hsa034103.62929604
5Spliceosome_Homo sapiens_hsa030403.36494886
6Fanconi anemia pathway_Homo sapiens_hsa034603.31113390
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06794843
8Cell cycle_Homo sapiens_hsa041103.05725121
9RNA transport_Homo sapiens_hsa030132.94793028
10Nucleotide excision repair_Homo sapiens_hsa034202.84480363
11Non-homologous end-joining_Homo sapiens_hsa034502.80416648
12Autoimmune thyroid disease_Homo sapiens_hsa053202.74665656
13One carbon pool by folate_Homo sapiens_hsa006702.73793459
14Allograft rejection_Homo sapiens_hsa053302.70709539
15B cell receptor signaling pathway_Homo sapiens_hsa046622.60020743
16Graft-versus-host disease_Homo sapiens_hsa053322.48685192
17mRNA surveillance pathway_Homo sapiens_hsa030152.36119263
18Pyrimidine metabolism_Homo sapiens_hsa002402.23270291
19Basal transcription factors_Homo sapiens_hsa030222.20120019
20Type I diabetes mellitus_Homo sapiens_hsa049401.99894665
21RNA degradation_Homo sapiens_hsa030181.99811482
22Acute myeloid leukemia_Homo sapiens_hsa052211.97605217
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95980291
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.93588203
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93246869
26Proteasome_Homo sapiens_hsa030501.88634169
27RNA polymerase_Homo sapiens_hsa030201.83070466
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.75613848
29Systemic lupus erythematosus_Homo sapiens_hsa053221.74677746
30p53 signaling pathway_Homo sapiens_hsa041151.69623434
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57896686
32Basal cell carcinoma_Homo sapiens_hsa052171.50839379
33Purine metabolism_Homo sapiens_hsa002301.37086772
34Ribosome_Homo sapiens_hsa030101.34559574
35Osteoclast differentiation_Homo sapiens_hsa043801.32802080
36Hematopoietic cell lineage_Homo sapiens_hsa046401.30644572
37Asthma_Homo sapiens_hsa053101.30430124
38MicroRNAs in cancer_Homo sapiens_hsa052061.27502333
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.14620059
40Oocyte meiosis_Homo sapiens_hsa041141.14429766
41Leishmaniasis_Homo sapiens_hsa051401.08230331
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08087356
43Chemokine signaling pathway_Homo sapiens_hsa040621.07288269
44Hedgehog signaling pathway_Homo sapiens_hsa043401.07158367
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07013031
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05809801
47Viral carcinogenesis_Homo sapiens_hsa052031.05645308
48Notch signaling pathway_Homo sapiens_hsa043301.04506873
49TNF signaling pathway_Homo sapiens_hsa046681.00944443
50HTLV-I infection_Homo sapiens_hsa051660.99593597
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97490259
52Epstein-Barr virus infection_Homo sapiens_hsa051690.93715378
53Dorso-ventral axis formation_Homo sapiens_hsa043200.92367274
54mTOR signaling pathway_Homo sapiens_hsa041500.90035426
55Toxoplasmosis_Homo sapiens_hsa051450.89371660
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86939782
57Prolactin signaling pathway_Homo sapiens_hsa049170.85739045
58Herpes simplex infection_Homo sapiens_hsa051680.85432093
59Hippo signaling pathway_Homo sapiens_hsa043900.82965153
60Hepatitis C_Homo sapiens_hsa051600.82621920
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82479958
62Alcoholism_Homo sapiens_hsa050340.82215394
63Lysine degradation_Homo sapiens_hsa003100.77899475
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76282441
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.73879219
66Small cell lung cancer_Homo sapiens_hsa052220.73874912
67Antigen processing and presentation_Homo sapiens_hsa046120.73386227
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72829082
69Selenocompound metabolism_Homo sapiens_hsa004500.72214001
70VEGF signaling pathway_Homo sapiens_hsa043700.68644758
71FoxO signaling pathway_Homo sapiens_hsa040680.66396363
72Vitamin B6 metabolism_Homo sapiens_hsa007500.64922131
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64136799
74Choline metabolism in cancer_Homo sapiens_hsa052310.64008871
75MAPK signaling pathway_Homo sapiens_hsa040100.62711013
76Inositol phosphate metabolism_Homo sapiens_hsa005620.62271630
77Renal cell carcinoma_Homo sapiens_hsa052110.60200060
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59083504
79Colorectal cancer_Homo sapiens_hsa052100.58360861
80Wnt signaling pathway_Homo sapiens_hsa043100.56659189
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.53746240
82ErbB signaling pathway_Homo sapiens_hsa040120.53637162
83Prostate cancer_Homo sapiens_hsa052150.52662595
84Tuberculosis_Homo sapiens_hsa051520.51917239
85Type II diabetes mellitus_Homo sapiens_hsa049300.51696982
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51439603
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51034960
88Shigellosis_Homo sapiens_hsa051310.49512861
89N-Glycan biosynthesis_Homo sapiens_hsa005100.49252485
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48191110
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47924459
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.45471677
93Legionellosis_Homo sapiens_hsa051340.44380818
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.44339741
95Pathways in cancer_Homo sapiens_hsa052000.43047414
96Steroid biosynthesis_Homo sapiens_hsa001000.42904903
97Biosynthesis of amino acids_Homo sapiens_hsa012300.40324068
98Pentose phosphate pathway_Homo sapiens_hsa000300.38903630
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38739050
100Renin-angiotensin system_Homo sapiens_hsa046140.38621435
101Regulation of autophagy_Homo sapiens_hsa041400.38179133
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37801406
103TGF-beta signaling pathway_Homo sapiens_hsa043500.35163647
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34782404
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34404607
106Thyroid cancer_Homo sapiens_hsa052160.32453672
107Non-small cell lung cancer_Homo sapiens_hsa052230.31961565
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31939610
109Bladder cancer_Homo sapiens_hsa052190.31298626
110Glutathione metabolism_Homo sapiens_hsa004800.31045335
111Endometrial cancer_Homo sapiens_hsa052130.29979835
112Hepatitis B_Homo sapiens_hsa051610.29946643
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29893054
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.29369576
115Insulin resistance_Homo sapiens_hsa049310.29041113
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28782616
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28245661
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26223427
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.25863320
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.25669811
121Melanoma_Homo sapiens_hsa052180.25054629
122HIF-1 signaling pathway_Homo sapiens_hsa040660.21775045
123Measles_Homo sapiens_hsa051620.21015668
124Arginine and proline metabolism_Homo sapiens_hsa003300.20616793
125Viral myocarditis_Homo sapiens_hsa054160.20321420
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19671045
127Chronic myeloid leukemia_Homo sapiens_hsa052200.19587805
128Apoptosis_Homo sapiens_hsa042100.18509561
129Adherens junction_Homo sapiens_hsa045200.18405127
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.17587915
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17486325
132Influenza A_Homo sapiens_hsa051640.17075027
133Primary immunodeficiency_Homo sapiens_hsa053400.15798484
134Axon guidance_Homo sapiens_hsa043600.15201785
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14597107
136Pancreatic cancer_Homo sapiens_hsa052120.13154262
137Tight junction_Homo sapiens_hsa045300.12322042
138Linoleic acid metabolism_Homo sapiens_hsa005910.12199362
139Huntingtons disease_Homo sapiens_hsa050160.11670970
140Proteoglycans in cancer_Homo sapiens_hsa052050.10125336
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10035524
142Glucagon signaling pathway_Homo sapiens_hsa049220.09525391
143Melanogenesis_Homo sapiens_hsa049160.06075232
144Arachidonic acid metabolism_Homo sapiens_hsa005900.05855591
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.05103589
146T cell receptor signaling pathway_Homo sapiens_hsa046600.04128072
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.03213415
148Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.02154067

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