PARVB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.63491257
2regulation of integrin activation (GO:0033623)6.64787117
3transcription from mitochondrial promoter (GO:0006390)6.44872424
4establishment of apical/basal cell polarity (GO:0035089)5.97537626
5embryonic process involved in female pregnancy (GO:0060136)5.90728162
6proline metabolic process (GO:0006560)5.62934540
7positive regulation of protein homooligomerization (GO:0032464)5.29964561
8replication fork processing (GO:0031297)5.22370589
9establishment of monopolar cell polarity (GO:0061162)5.15990754
10establishment or maintenance of monopolar cell polarity (GO:0061339)5.15990754
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.81668937
12apoptotic process involved in morphogenesis (GO:0060561)4.69633928
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.67996317
14regulation of skeletal muscle contraction (GO:0014819)4.53428963
15negative regulation of JAK-STAT cascade (GO:0046426)4.37988864
16mitochondrial DNA metabolic process (GO:0032042)4.34314484
17oxidative demethylation (GO:0070989)4.26958495
18mitotic G1 DNA damage checkpoint (GO:0031571)4.25673604
19regulation of protein homooligomerization (GO:0032462)4.23203069
20sarcoplasmic reticulum calcium ion transport (GO:0070296)4.19004998
21embryonic placenta development (GO:0001892)4.17959261
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.07651399
23labyrinthine layer development (GO:0060711)4.07625856
24negative regulation of potassium ion transmembrane transport (GO:1901380)4.07531177
25protein localization to endosome (GO:0036010)4.04402448
26skeletal muscle contraction (GO:0003009)3.88626250
27mitotic G1/S transition checkpoint (GO:0044819)3.88034652
28G1 DNA damage checkpoint (GO:0044783)3.84894648
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.80879566
30embryonic camera-type eye development (GO:0031076)3.77539605
31plasma membrane repair (GO:0001778)3.76315133
32actin-mediated cell contraction (GO:0070252)3.74804108
33sarcomere organization (GO:0045214)3.73926575
34cellular response to ATP (GO:0071318)3.71534747
35positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.66817248
36DNA strand renaturation (GO:0000733)3.61205167
37mitochondrial fusion (GO:0008053)3.55302612
38DNA deamination (GO:0045006)3.52323169
39ventricular trabecula myocardium morphogenesis (GO:0003222)3.50696774
40negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.50157161
41cardiac muscle cell development (GO:0055013)3.49608420
42regulation of translational fidelity (GO:0006450)3.48100131
43positive regulation of developmental pigmentation (GO:0048087)3.45392432
44poly(A)+ mRNA export from nucleus (GO:0016973)3.44832091
45negative regulation of fatty acid biosynthetic process (GO:0045717)3.44085486
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.42236006
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42236006
48negative regulation of cell cycle arrest (GO:0071157)3.39542119
49apoptotic process involved in development (GO:1902742)3.35952047
50cardiac myofibril assembly (GO:0055003)3.31876389
51positive regulation of protein oligomerization (GO:0032461)3.31182423
52regulation of posttranscriptional gene silencing (GO:0060147)3.29154691
53regulation of gene silencing by miRNA (GO:0060964)3.29154691
54regulation of gene silencing by RNA (GO:0060966)3.29154691
55cellular response to zinc ion (GO:0071294)3.28611904
56cardiac cell development (GO:0055006)3.28352827
57membrane tubulation (GO:0097320)3.27851761
58positive regulation of receptor recycling (GO:0001921)3.24335095
59cellular ketone body metabolic process (GO:0046950)3.21902001
60negative regulation of Ras GTPase activity (GO:0034261)3.20539055
61polarized epithelial cell differentiation (GO:0030859)3.18206245
62ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.15569784
63positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.13365305
64myofibril assembly (GO:0030239)3.11746594
65positive regulation of microtubule polymerization (GO:0031116)3.08943951
66mitotic nuclear envelope reassembly (GO:0007084)3.06960592
67nuclear envelope reassembly (GO:0031468)3.06960592
68actin-myosin filament sliding (GO:0033275)3.06931049
69muscle filament sliding (GO:0030049)3.06931049
70DNA integration (GO:0015074)3.05498004
71regulation of platelet aggregation (GO:0090330)3.04967143
72respiratory system process (GO:0003016)3.04213254
73negative regulation of heart rate (GO:0010459)3.03814366
74valine metabolic process (GO:0006573)3.01315642
75cell migration in hindbrain (GO:0021535)3.01218857
76viral mRNA export from host cell nucleus (GO:0046784)3.00843016
77convergent extension (GO:0060026)3.00173300
78histamine secretion (GO:0001821)2.99308017
79anatomical structure regression (GO:0060033)2.98520616
80glial cell migration (GO:0008347)2.97877646
81xenobiotic catabolic process (GO:0042178)2.97836674
82enteric nervous system development (GO:0048484)2.97148301
83ketone body metabolic process (GO:1902224)2.96046599
84positive regulation of glycolytic process (GO:0045821)2.95053024
85cardiac muscle tissue morphogenesis (GO:0055008)2.93834424
86regulation of early endosome to late endosome transport (GO:2000641)2.92903574
87negative regulation of protein oligomerization (GO:0032460)2.91796336
88spliceosomal tri-snRNP complex assembly (GO:0000244)2.90089692
89regulation of cell size (GO:0008361)2.88859465
90neutrophil activation involved in immune response (GO:0002283)2.88647657
91trophectodermal cell differentiation (GO:0001829)2.87378551
92striated muscle contraction (GO:0006941)2.86447742
93regulation of hippo signaling (GO:0035330)2.86344395
94negative regulation of nucleotide catabolic process (GO:0030812)2.84869746
95positive regulation by host of viral transcription (GO:0043923)2.84806920
96regulation of platelet activation (GO:0010543)2.84790276
97face development (GO:0060324)2.84660608
98heart trabecula morphogenesis (GO:0061384)2.84650061
99regulation of protein oligomerization (GO:0032459)2.82700851
100establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81207441
101mitochondrion transport along microtubule (GO:0047497)2.81207441
102regulation of relaxation of muscle (GO:1901077)2.80846435
103positive regulation of chromosome segregation (GO:0051984)2.79211817
104negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.79171535
105developmental programmed cell death (GO:0010623)2.78538223
106regulation of B cell apoptotic process (GO:0002902)2.78065858
107establishment or maintenance of bipolar cell polarity (GO:0061245)2.74911147
108establishment or maintenance of apical/basal cell polarity (GO:0035088)2.74911147
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.74097955
110anterior/posterior axis specification, embryo (GO:0008595)2.73734766
111regulation of hexokinase activity (GO:1903299)2.73524901
112regulation of glucokinase activity (GO:0033131)2.73524901
113regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73419670
114regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.72047689
115establishment of mitochondrion localization (GO:0051654)2.71432885
116negative regulation of purine nucleotide catabolic process (GO:0033122)2.70615393
117positive regulation of gamma-delta T cell activation (GO:0046645)2.70108864
118mRNA cleavage (GO:0006379)2.68630206
119regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68438216
120negative regulation of erythrocyte differentiation (GO:0045647)2.67197608
121inositol phosphate catabolic process (GO:0071545)2.66402578
122actin filament-based movement (GO:0030048)2.65577455
123cardiac muscle contraction (GO:0060048)2.65220813
124formation of translation preinitiation complex (GO:0001731)2.65199190
125histone H4-K12 acetylation (GO:0043983)2.64355887
126DNA demethylation (GO:0080111)2.63671099
127hypotonic response (GO:0006971)2.63327422
128trabecula morphogenesis (GO:0061383)2.62826078
129negative regulation of androgen receptor signaling pathway (GO:0060766)2.61515179
130regulation of phospholipid biosynthetic process (GO:0071071)2.60561385
131creatine metabolic process (GO:0006600)2.56075088
132cellular response to arsenic-containing substance (GO:0071243)2.55458905
133purinergic nucleotide receptor signaling pathway (GO:0035590)2.53873411
134cytidine metabolic process (GO:0046087)2.52406404
135cytidine catabolic process (GO:0006216)2.52406404
136cytidine deamination (GO:0009972)2.52406404
137angiogenesis involved in wound healing (GO:0060055)2.51492413
138nitric oxide mediated signal transduction (GO:0007263)2.50260430
139negative regulation of adherens junction organization (GO:1903392)2.49130426
140negative regulation of focal adhesion assembly (GO:0051895)2.49130426
141negative regulation of cell junction assembly (GO:1901889)2.49130426
142phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48242789
143inositol phosphate dephosphorylation (GO:0046855)2.48242789
144negative regulation of calcium ion transport into cytosol (GO:0010523)2.45323794
145megakaryocyte development (GO:0035855)2.45013958
146adenosine receptor signaling pathway (GO:0001973)2.44550795
147regulation of gamma-delta T cell activation (GO:0046643)2.43150591
148thrombin receptor signaling pathway (GO:0070493)2.43048977
149negative regulation of calcium ion transmembrane transport (GO:1903170)2.41054533
150negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.41054533
151purine nucleotide salvage (GO:0032261)2.38828286
152endothelium development (GO:0003158)2.38467309
153heart process (GO:0003015)2.36625719
154heart contraction (GO:0060047)2.36625719
155negative regulation of platelet activation (GO:0010544)2.36173570
156negative regulation of potassium ion transport (GO:0043267)2.35577925
157amino sugar catabolic process (GO:0046348)2.35160193
158regulation of type B pancreatic cell apoptotic process (GO:2000674)2.33488923
159glycerophospholipid catabolic process (GO:0046475)2.33328451
160mitochondrial calcium ion homeostasis (GO:0051560)2.32292146
161B cell receptor signaling pathway (GO:0050853)2.30966260
162regulation of T-helper 1 cell differentiation (GO:0045625)2.30556150
163negative regulation of phagocytosis (GO:0050765)2.29760072
164N-acetylneuraminate metabolic process (GO:0006054)2.28455023
165pigment cell differentiation (GO:0050931)2.28204479
166histamine transport (GO:0051608)2.28194778
167skeletal muscle tissue regeneration (GO:0043403)2.28026633
168cellular response to thyroid hormone stimulus (GO:0097067)2.27953603
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.26461121
170positive regulation of mast cell activation (GO:0033005)2.26341627
171negative regulation of calcium ion transport (GO:0051926)2.26055719
172fatty acid transmembrane transport (GO:1902001)2.25463196
173cardiolipin metabolic process (GO:0032048)2.25105210
174B cell homeostasis (GO:0001782)2.24308265
175negative regulation of gluconeogenesis (GO:0045721)2.24263588
176regulation of B cell receptor signaling pathway (GO:0050855)2.24072601
177endosome to pigment granule transport (GO:0043485)2.23168949
178endosome to melanosome transport (GO:0035646)2.23168949
179platelet dense granule organization (GO:0060155)2.23141834
180fatty acid homeostasis (GO:0055089)2.22563130
181regulation of inositol phosphate biosynthetic process (GO:0010919)2.22479593
182glycogen catabolic process (GO:0005980)2.22437506
183negative regulation of homotypic cell-cell adhesion (GO:0034111)2.22379901
184regulation of memory T cell differentiation (GO:0043380)2.20548977
185mitochondrial genome maintenance (GO:0000002)2.20154765
186CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.19892501
187positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.19638034
188adenosine metabolic process (GO:0046085)2.19333346
189regulation of germinal center formation (GO:0002634)2.18615785
190purine-containing compound salvage (GO:0043101)2.18309021
191positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.16861732
192immunoglobulin mediated immune response (GO:0016064)2.16438684
193succinate metabolic process (GO:0006105)2.16326930
194germinal center formation (GO:0002467)2.15289710
195insulin secretion (GO:0030073)2.13745264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.54077574
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.11945975
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.06778229
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.06778229
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.06778229
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.64063729
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.60145561
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53549175
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.30286188
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.28318160
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.69906937
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.64873645
13LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.52983747
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52135433
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51705888
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.51196596
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48543569
18* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.47582603
19NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.47067877
20SCL_19346495_ChIP-Seq_HPC-7_Human2.41231276
21* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.35523859
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.27967709
23GATA1_22025678_ChIP-Seq_K562_Human2.24129666
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.22637579
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.20930634
26* IRF8_27001747_Chip-Seq_BMDM_Mouse2.17865968
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17274969
28VDR_21846776_ChIP-Seq_THP-1_Human2.15013606
29ZNF263_19887448_ChIP-Seq_K562_Human2.13886218
30GATA1_19941826_ChIP-Seq_K562_Human2.13414121
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.09156339
32POU5F1_16518401_ChIP-PET_MESCs_Mouse2.07002647
33* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05897708
34LXR_22292898_ChIP-Seq_THP-1_Human2.03929623
35TCF3_18692474_ChIP-Seq_MESCs_Mouse2.02374101
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99593143
37* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97694556
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95177026
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91256485
40GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.90818522
41DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.89791476
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88497424
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.88242430
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.86187806
45NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.83674941
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82413364
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81706550
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77370027
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76969847
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75103755
51* SPI1_23127762_ChIP-Seq_K562_Human1.73983641
52RACK7_27058665_Chip-Seq_MCF-7_Human1.73804846
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.73642512
54* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73322960
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73150589
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.73052911
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.72583647
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71662406
59* GATA1_19941827_ChIP-Seq_MEL_Mouse1.70376916
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69735660
61KDM2B_26808549_Chip-Seq_DND41_Human1.60831654
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60101669
63* GATA2_19941826_ChIP-Seq_K562_Human1.58511423
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.56619453
65* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.48579996
66* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.45791635
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45064400
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44918608
69MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44486862
70* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44469513
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43330207
72* STAT1_20625510_ChIP-Seq_HELA_Human1.42960586
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.41228691
74* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.40839795
75RUNX_20019798_ChIP-Seq_JUKART_Human1.39243799
76IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37323143
77NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.36680740
78SOX2_18692474_ChIP-Seq_MESCs_Mouse1.35954441
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35929257
80SOX2_18692474_ChIP-Seq_MEFs_Mouse1.35766810
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.35623234
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34927069
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.34338471
84MYC_18555785_ChIP-Seq_MESCs_Mouse1.33860334
85KDM2B_26808549_Chip-Seq_K562_Human1.33107220
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32577675
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32269355
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31470314
89POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.30957896
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30905924
91* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30530059
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29405697
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29006632
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28543084
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25914304
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24899489
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24808086
98VDR_24763502_ChIP-Seq_THP-1_Human1.24504946
99TFEB_21752829_ChIP-Seq_HELA_Human1.24493994
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23606934
101NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23433963
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23426494
103SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.22649084
104* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22122749
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21436391
106* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21060166
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20984365
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20794083
109HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20397799
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20370624
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20127219
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.19985324
113ESR2_21235772_ChIP-Seq_MCF-7_Human1.19580897
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19003703
115VDR_24787735_ChIP-Seq_THP-1_Human1.16583199
116SPI1_20517297_ChIP-Seq_HL60_Human1.16123620
117OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16115487
118TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.15741310
119GATA3_26560356_Chip-Seq_TH2_Human1.14165151
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13773220
121MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13230467
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13042181
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12582746
124* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12226598
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11909438
126* MYB_26560356_Chip-Seq_TH2_Human1.11771691
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11739666
128STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11548163
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11316039
130GATA3_27048872_Chip-Seq_THYMUS_Human1.10331619
131* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10129840
132* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09672458
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.08888565
134IGF1R_20145208_ChIP-Seq_DFB_Human1.08165699
135TP53_23651856_ChIP-Seq_MEFs_Mouse1.07846988
136ELF1_20517297_ChIP-Seq_JURKAT_Human1.07720070
137CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07673317
138CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06880040
139* MAF_26560356_Chip-Seq_TH1_Human1.06694039
140CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06641033
141* SPI1_23547873_ChIP-Seq_NB4_Human1.06070979
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05935062
143RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05641239
144BRD4_27068464_Chip-Seq_AML-cells_Mouse1.05262155
145UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04082118
146MYC_22102868_ChIP-Seq_BL_Human1.04001085
147ETS1_22383799_ChIP-Seq_G1ME_Mouse1.03832787
148TP53_22127205_ChIP-Seq_IMR90_Human1.03811597
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02965573
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02914422
151FLI1_27457419_Chip-Seq_LIVER_Mouse1.02447477
152PU_27001747_Chip-Seq_BMDM_Mouse1.01534500
153YY1_22570637_ChIP-Seq_MALME-3M_Human1.01507003
154* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01301476
155HTT_18923047_ChIP-ChIP_STHdh_Human1.00820643
156EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00189651
157BCOR_27268052_Chip-Seq_Bcells_Human0.98496620
158YY1_21170310_ChIP-Seq_MESCs_Mouse0.98491446
159KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98196172
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97090064
161MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96800226
162FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95909997
163BCL6_27268052_Chip-Seq_Bcells_Human0.95535868
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.95180470
165* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94442264
166SA1_27219007_Chip-Seq_ERYTHROID_Human0.94063838
167CTCF_27219007_Chip-Seq_Bcells_Human0.93893230
168SMRT_27268052_Chip-Seq_Bcells_Human0.93354259
169TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92555326
170RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92247123
171P68_20966046_ChIP-Seq_HELA_Human0.91721352
172KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91146410
173E2F1_20622854_ChIP-Seq_HELA_Human0.90948811
174RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90487002
175TBX20_22328084_ChIP-Seq_HEART_Mouse0.90166836
176TBX20_22080862_ChIP-Seq_HEART_Mouse0.90166836
177* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89734608
178RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89456088
179EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88472566
180OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86690709
181PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83940947
182* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83896423
183MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82916099
184GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.81986646
185OCT4_20526341_ChIP-Seq_ESCs_Human0.81652255
186PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81145370
187* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80362143
188RXR_22158963_ChIP-Seq_LIVER_Mouse0.80290911
189GBX2_23144817_ChIP-Seq_PC3_Human0.79953738
190JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79555279
191EZH2_27294783_Chip-Seq_NPCs_Mouse0.78707192
192MYB_26560356_Chip-Seq_TH1_Human0.78432323
193GATA3_26560356_Chip-Seq_TH1_Human0.77488727
194SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77369272
195TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77251764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.10244505
2MP0008057_abnormal_DNA_replication3.80214178
3MP0009278_abnormal_bone_marrow3.42130067
4MP0005464_abnormal_platelet_physiology3.24351329
5MP0004233_abnormal_muscle_weight3.22350740
6MP0010030_abnormal_orbit_morphology3.21735115
7MP0000751_myopathy3.20463108
8MP0003303_peritoneal_inflammation2.88621555
9MP0004084_abnormal_cardiac_muscle2.81717947
10MP0004510_myositis2.73922271
11MP0005330_cardiomyopathy2.72725166
12MP0005623_abnormal_meninges_morphology2.63091680
13MP0002269_muscular_atrophy2.37822908
14MP0003137_abnormal_impulse_conducting2.35010486
15MP0002837_dystrophic_cardiac_calcinosis2.31913851
16MP0003828_pulmonary_edema2.25686857
17MP0000749_muscle_degeneration2.18829599
18MP0005451_abnormal_body_composition2.14286077
19MP0004087_abnormal_muscle_fiber2.11823380
20MP0010630_abnormal_cardiac_muscle2.11679134
21MP0003567_abnormal_fetal_cardiomyocyte2.00862958
22MP0004133_heterotaxia2.00593153
23MP0001835_abnormal_antigen_presentation1.95984621
24MP0000685_abnormal_immune_system1.93674232
25MP0002106_abnormal_muscle_physiology1.92412043
26MP0005671_abnormal_response_to1.88088598
27MP0008775_abnormal_heart_ventricle1.81571927
28MP0000372_irregular_coat_pigmentation1.80291750
29MP0000750_abnormal_muscle_regeneration1.79688804
30MP0003724_increased_susceptibility_to1.78483250
31MP0006036_abnormal_mitochondrial_physio1.75979260
32MP0003646_muscle_fatigue1.75777239
33MP0004145_abnormal_muscle_electrophysio1.73055021
34MP0004215_abnormal_myocardial_fiber1.72864692
35MP0004036_abnormal_muscle_relaxation1.70709446
36MP0002148_abnormal_hypersensitivity_rea1.70034811
37MP0000013_abnormal_adipose_tissue1.69063561
38MP0005000_abnormal_immune_tolerance1.68423957
39MP0001790_abnormal_immune_system1.67777852
40MP0005387_immune_system_phenotype1.67777852
41MP0003195_calcinosis1.65706631
42MP0005369_muscle_phenotype1.58738157
43MP0002693_abnormal_pancreas_physiology1.58180897
44MP0000759_abnormal_skeletal_muscle1.56210648
45MP0003283_abnormal_digestive_organ1.55915536
46MP0002332_abnormal_exercise_endurance1.55159383
47MP0002653_abnormal_ependyma_morphology1.53471202
48MP0000747_muscle_weakness1.52356976
49MP0009840_abnormal_foam_cell1.45000327
50MP0008995_early_reproductive_senescence1.42950024
51MP0003119_abnormal_digestive_system1.40797040
52MP0002086_abnormal_extraembryonic_tissu1.39726345
53MP0000015_abnormal_ear_pigmentation1.38292623
54MP0005645_abnormal_hypothalamus_physiol1.37220791
55MP0002084_abnormal_developmental_patter1.35129310
56MP0005058_abnormal_lysosome_morphology1.33465326
57MP0004185_abnormal_adipocyte_glucose1.33104986
58MP0006072_abnormal_retinal_apoptosis1.32585036
59MP0003890_abnormal_embryonic-extraembry1.31579566
60MP0001697_abnormal_embryo_size1.31558894
61MP0004272_abnormal_basement_membrane1.31464408
62MP0003566_abnormal_cell_adhesion1.31425230
63MP0002127_abnormal_cardiovascular_syste1.30801511
64MP0003950_abnormal_plasma_membrane1.30312114
65MP0005385_cardiovascular_system_phenoty1.30034375
66MP0001544_abnormal_cardiovascular_syste1.30034375
67MP0003075_altered_response_to1.30029047
68MP0001800_abnormal_humoral_immune1.29622975
69MP0002085_abnormal_embryonic_tissue1.29315847
70MP0002723_abnormal_immune_serum1.29033187
71MP0002249_abnormal_larynx_morphology1.26666973
72MP0005075_abnormal_melanosome_morpholog1.25678814
73MP0003221_abnormal_cardiomyocyte_apopto1.25294983
74MP0004197_abnormal_fetal_growth/weight/1.25115316
75MP0002138_abnormal_hepatobiliary_system1.25017514
76MP0000733_abnormal_muscle_development1.24891893
77MP0005380_embryogenesis_phenotype1.24703980
78MP0001672_abnormal_embryogenesis/_devel1.24703980
79MP0002009_preneoplasia1.23921578
80MP0002452_abnormal_antigen_presenting1.22440867
81MP0003705_abnormal_hypodermis_morpholog1.21704345
82MP0009785_altered_susceptibility_to1.21081117
83MP0004484_altered_response_of1.19491452
84MP0005535_abnormal_body_temperature1.18764415
85MP0002419_abnormal_innate_immunity1.17950178
86MP0003984_embryonic_growth_retardation1.17325243
87MP0003300_gastrointestinal_ulcer1.16806063
88MP0002972_abnormal_cardiac_muscle1.15055965
89MP0003453_abnormal_keratinocyte_physiol1.14611634
90MP0001293_anophthalmia1.14519254
91MP0003436_decreased_susceptibility_to1.14266425
92MP0006138_congestive_heart_failure1.13153226
93MP0002078_abnormal_glucose_homeostasis1.13125270
94MP0008932_abnormal_embryonic_tissue1.12569870
95MP0002088_abnormal_embryonic_growth/wei1.11394972
96MP0002108_abnormal_muscle_morphology1.10991413
97MP0000762_abnormal_tongue_morphology1.09997435
98MP0009046_muscle_twitch1.09836326
99MP0005025_abnormal_response_to1.09708891
100MP0005379_endocrine/exocrine_gland_phen1.08125993
101MP0003806_abnormal_nucleotide_metabolis1.07978931
102MP0002420_abnormal_adaptive_immunity1.07976563
103MP0001661_extended_life_span1.07670868
104MP0000266_abnormal_heart_morphology1.07386262
105MP0003172_abnormal_lysosome_physiology1.06880581
106MP0003136_yellow_coat_color1.06744902
107MP0001819_abnormal_immune_cell1.06089888
108MP0000003_abnormal_adipose_tissue1.05719453
109MP0005165_increased_susceptibility_to1.05243892
110MP0005620_abnormal_muscle_contractility1.05091673
111MP0001545_abnormal_hematopoietic_system1.04638072
112MP0005397_hematopoietic_system_phenotyp1.04638072
113MP0002282_abnormal_trachea_morphology1.03691280
114MP0004130_abnormal_muscle_cell1.00039697
115MP0008004_abnormal_stomach_pH0.99853332
116MP0009780_abnormal_chondrocyte_physiolo0.99352356
117MP0002925_abnormal_cardiovascular_devel0.99269625
118MP0000230_abnormal_systemic_arterial0.99266501
119MP0004147_increased_porphyrin_level0.98962928
120MP0001730_embryonic_growth_arrest0.98187890
121MP0001845_abnormal_inflammatory_respons0.97615991
122MP0003634_abnormal_glial_cell0.96189896
123MP0005083_abnormal_biliary_tract0.92843658
124MP0000462_abnormal_digestive_system0.92832990
125MP0006082_CNS_inflammation0.92202795
126MP0009764_decreased_sensitivity_to0.92005416
127MP0005084_abnormal_gallbladder_morpholo0.90681617
128MP0005076_abnormal_cell_differentiation0.89379804
129MP0000689_abnormal_spleen_morphology0.89024561
130MP0003786_premature_aging0.87706724
131MP0002398_abnormal_bone_marrow0.87578589
132MP0001944_abnormal_pancreas_morphology0.87364751
133MP0003935_abnormal_craniofacial_develop0.86750107
134MP0000343_altered_response_to0.86640107
135MP0008872_abnormal_physiological_respon0.86605370
136MP0002163_abnormal_gland_morphology0.86407751
137MP0001533_abnormal_skeleton_physiology0.85888028
138MP0004957_abnormal_blastocyst_morpholog0.85349226
139MP0005266_abnormal_metabolism0.84675077
140MP0010094_abnormal_chromosome_stability0.83667074
141MP0002971_abnormal_brown_adipose0.83298459
142MP0003656_abnormal_erythrocyte_physiolo0.83271186
143MP0001784_abnormal_fluid_regulation0.82217689
144MP0002080_prenatal_lethality0.81207386
145MP0008469_abnormal_protein_level0.81191298
146MP0000716_abnormal_immune_system0.79898714
147MP0003385_abnormal_body_wall0.78433774
148MP0005332_abnormal_amino_acid0.77427326
149MP0000465_gastrointestinal_hemorrhage0.76617026
150MP0005167_abnormal_blood-brain_barrier0.76127552
151MP0002139_abnormal_hepatobiliary_system0.74769447
152MP0003879_abnormal_hair_cell0.74722587
153MP0003755_abnormal_palate_morphology0.74680347
154MP0001727_abnormal_embryo_implantation0.74258746
155MP0002118_abnormal_lipid_homeostasis0.74162230
156MP0000371_diluted_coat_color0.74116556
157MP0002111_abnormal_tail_morphology0.74106671
158MP0000579_abnormal_nail_morphology0.73915915
159MP0010352_gastrointestinal_tract_polyps0.73365777
160MP0005375_adipose_tissue_phenotype0.72898128
161MP0000920_abnormal_myelination0.72794791
162MP0004085_abnormal_heartbeat0.71759005
163MP0002932_abnormal_joint_morphology0.71267789
164MP0003279_aneurysm0.70766468
165MP0003045_fibrosis0.67827630
166MP0000470_abnormal_stomach_morphology0.67201116
167MP0001614_abnormal_blood_vessel0.67071060

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.80029621
2Muscle fiber inclusion bodies (HP:0100299)5.74089929
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.59555563
4Rib fusion (HP:0000902)4.34600703
5Type 1 muscle fiber predominance (HP:0003803)4.19802337
6Rectal fistula (HP:0100590)4.11853358
7Rectovaginal fistula (HP:0000143)4.11853358
8Concave nail (HP:0001598)4.08336567
9Petechiae (HP:0000967)3.98409184
10Prolonged bleeding time (HP:0003010)3.87103298
11Sudden death (HP:0001699)3.85902951
12Exercise-induced myalgia (HP:0003738)3.75567219
13Muscle fiber splitting (HP:0003555)3.69179178
14Intestinal fistula (HP:0100819)3.66514861
15Asymmetric septal hypertrophy (HP:0001670)3.66130414
16Ketoacidosis (HP:0001993)3.63274406
17Ulnar bowing (HP:0003031)3.59550423
18Annular pancreas (HP:0001734)3.56434817
19Vaginal fistula (HP:0004320)3.49739468
20Hyporeflexia of lower limbs (HP:0002600)3.46036116
21Diaphragmatic weakness (HP:0009113)3.45964590
22Hypoglycemic coma (HP:0001325)3.39347333
23Coronal craniosynostosis (HP:0004440)3.33001259
24Turricephaly (HP:0000262)3.30852439
25Short humerus (HP:0005792)3.30780024
26Distal arthrogryposis (HP:0005684)3.21394702
27Aplasia/hypoplasia of the humerus (HP:0006507)3.20870458
28Hypoglycemic seizures (HP:0002173)3.20867465
29Ventricular tachycardia (HP:0004756)3.20339564
30Exercise-induced muscle cramps (HP:0003710)3.17328436
31Premature skin wrinkling (HP:0100678)3.14375601
32Hyperinsulinemic hypoglycemia (HP:0000825)3.11930150
33Abnormal hemoglobin (HP:0011902)3.08855948
34Hypochromic microcytic anemia (HP:0004840)3.07337450
35Alopecia of scalp (HP:0002293)3.07008673
36Muscle fibrillation (HP:0010546)3.06691348
37Rhabdomyolysis (HP:0003201)3.03885727
38Aplasia of the musculature (HP:0100854)3.02652577
39Cerebral aneurysm (HP:0004944)3.01263322
40Increased IgM level (HP:0003496)3.01046330
41Purpura (HP:0000979)2.99678040
42Pustule (HP:0200039)2.97009502
43Hematochezia (HP:0002573)2.96654921
44Large for gestational age (HP:0001520)2.92719413
45Abnormality of liposaccharide metabolism (HP:0010968)2.91824633
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.91824633
47Abnormality of glycolipid metabolism (HP:0010969)2.91824633
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89844836
49Vertebral hypoplasia (HP:0008417)2.89134312
50Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.89134312
51Alacrima (HP:0000522)2.89096271
52Congenital hip dislocation (HP:0001374)2.87742182
53Facial hemangioma (HP:0000329)2.84426328
54Increased connective tissue (HP:0009025)2.83793424
55Muscle hypertrophy of the lower extremities (HP:0008968)2.82406361
56Anteriorly placed anus (HP:0001545)2.81317416
57Absent radius (HP:0003974)2.76819801
58Abnormality of the pancreatic islet cells (HP:0006476)2.75040013
59Abnormality of endocrine pancreas physiology (HP:0012093)2.75040013
60Bundle branch block (HP:0011710)2.74608442
61Calf muscle hypertrophy (HP:0008981)2.73535837
62Myopathic facies (HP:0002058)2.72221407
63Abnormality of skeletal muscle fiber size (HP:0012084)2.67631238
64Difficulty climbing stairs (HP:0003551)2.66159685
65Absent forearm bone (HP:0003953)2.61043224
66Aplasia involving forearm bones (HP:0009822)2.61043224
67Hyperglycemia (HP:0003074)2.60085857
68Male infertility (HP:0003251)2.58141697
69Hypoplastic ischia (HP:0003175)2.57209728
70Atrial fibrillation (HP:0005110)2.56579739
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.53992745
72Short chin (HP:0000331)2.53709583
73Symptomatic seizures (HP:0011145)2.52817185
74Ketosis (HP:0001946)2.52491769
75Tongue fasciculations (HP:0001308)2.51900470
76Frequent falls (HP:0002359)2.51082574
77Absent hand (HP:0004050)2.48163898
78Primary atrial arrhythmia (HP:0001692)2.45003266
79Intestinal atresia (HP:0011100)2.44753965
80Abnormality of the calf musculature (HP:0001430)2.44731975
81Spontaneous hematomas (HP:0007420)2.43531429
82Epistaxis (HP:0000421)2.43152606
83Aplasia/Hypoplasia involving the musculature (HP:0001460)2.42702381
84Abnormality of the aortic arch (HP:0012303)2.40844790
85Supraventricular arrhythmia (HP:0005115)2.40030066
86Myoglobinuria (HP:0002913)2.38739604
87Difficulty running (HP:0009046)2.37400200
88EMG: myopathic abnormalities (HP:0003458)2.37222191
89Gastrointestinal stroma tumor (HP:0100723)2.36061769
90Polycythemia (HP:0001901)2.35949896
91Bulbar palsy (HP:0001283)2.35073386
92Myotonia (HP:0002486)2.35008358
93Supraventricular tachycardia (HP:0004755)2.34716136
94Orthostatic hypotension (HP:0001278)2.32515143
95Increased density of long bones (HP:0006392)2.30730845
96Late onset (HP:0003584)2.30598042
97Pancreatic islet-cell hyperplasia (HP:0004510)2.30325626
98Subaortic stenosis (HP:0001682)2.28146297
99Abnormality of the left ventricular outflow tract (HP:0011103)2.28146297
100Increased variability in muscle fiber diameter (HP:0003557)2.27057579
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25354736
102Albinism (HP:0001022)2.24780553
103Hyperlipoproteinemia (HP:0010980)2.24321984
104Paralysis (HP:0003470)2.24190934
105Neck muscle weakness (HP:0000467)2.21426938
106Rimmed vacuoles (HP:0003805)2.21287136
107Vertebral fusion (HP:0002948)2.19647176
108Hamartoma (HP:0010566)2.19144227
109Menorrhagia (HP:0000132)2.19088290
110Generalized amyotrophy (HP:0003700)2.17062746
111Ulnar deviation of the wrist (HP:0003049)2.16785247
112EMG: neuropathic changes (HP:0003445)2.16455230
113Abnormality of the ischium (HP:0003174)2.15893070
114Fetal akinesia sequence (HP:0001989)2.15218032
115Clumsiness (HP:0002312)2.14030795
116Lipoatrophy (HP:0100578)2.12379959
117Abnormal platelet volume (HP:0011876)2.10358927
118Hypotrichosis (HP:0001006)2.09662167
119Increased mean platelet volume (HP:0011877)2.08827694
120Stomatitis (HP:0010280)2.07695793
121Hypoplastic heart (HP:0001961)2.04674583
122Round ear (HP:0100830)2.04490900
123Generalized muscle weakness (HP:0003324)2.03140702
124Increased neuronal autofluorescent lipopigment (HP:0002074)2.00963921
125Insulin-resistant diabetes mellitus (HP:0000831)2.00907692
126Vacuolated lymphocytes (HP:0001922)2.00885068
127Ventricular fibrillation (HP:0001663)2.00551866
128Hypokinesia (HP:0002375)1.99726868
129Poikiloderma (HP:0001029)1.99327268
130Distal lower limb muscle weakness (HP:0009053)1.98668886
131Increased cerebral lipofuscin (HP:0011813)1.98443935
132Bowing of the arm (HP:0006488)1.95217655
133Bowed forearm bones (HP:0003956)1.95217655
134Decreased lacrimation (HP:0000633)1.95177905
135Dysautonomia (HP:0002459)1.94366460
136Diminished movement (HP:0002374)1.94309945
137Popliteal pterygium (HP:0009756)1.93915101
138Abnormality of iron homeostasis (HP:0011031)1.92787499
139Increased serum ferritin (HP:0003281)1.91981513
140Fatigue (HP:0012378)1.89113116
141Abnormality of lateral ventricle (HP:0030047)1.87009309
142Abnormality of the parathyroid morphology (HP:0011766)1.86836097
143Hyperthyroidism (HP:0000836)1.86602300
144Dysostosis multiplex (HP:0000943)1.84729863
145Ventricular arrhythmia (HP:0004308)1.84360074
146Broad alveolar ridges (HP:0000187)1.83736481
147Impaired platelet aggregation (HP:0003540)1.83005767
148Abnormal platelet function (HP:0011869)1.83005767
149Gingival bleeding (HP:0000225)1.81349823
150Areflexia of lower limbs (HP:0002522)1.78841925
151Abnormality of transition element cation homeostasis (HP:0011030)1.78595919
152Choanal stenosis (HP:0000452)1.78407898
153Abnormality of macrophages (HP:0004311)1.78279621
154Dilated cardiomyopathy (HP:0001644)1.77538484
155Split hand (HP:0001171)1.77349131
156Testicular atrophy (HP:0000029)1.76414873
157Prominent metopic ridge (HP:0005487)1.74884605
158Abnormality of the labia minora (HP:0012880)1.74497279
159Abnormality of the astrocytes (HP:0100707)1.74099306
160Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73587647
161Abnormality of polysaccharide metabolism (HP:0011012)1.73587647
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73587647
163Acute hepatic failure (HP:0006554)1.71843948
164Heart block (HP:0012722)1.70108717
165Abnormal pupillary function (HP:0007686)1.68305183
166Hepatic necrosis (HP:0002605)1.68163315
167Muscle stiffness (HP:0003552)1.65876482
168Abnormal atrioventricular conduction (HP:0005150)1.62759916
169Gowers sign (HP:0003391)1.61761170
170Absent phalangeal crease (HP:0006109)1.61724897
171Muscular dystrophy (HP:0003560)1.61453748
172Ragged-red muscle fibers (HP:0003200)1.60874041
173Abnormality of dicarboxylic acid metabolism (HP:0010995)1.59960484
174Dicarboxylic aciduria (HP:0003215)1.59960484
175Chest pain (HP:0100749)1.58292456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.31522830
2FRK5.38959083
3DDR24.22606808
4TYRO33.43065150
5MAP3K63.37493042
6MAPK153.34312955
7PINK13.13585546
8MAP3K113.04282209
9FGR2.86671484
10RIPK42.63607424
11UHMK12.56125019
12BMX2.42648019
13PHKG12.37779446
14PHKG22.37779446
15MATK2.36150891
16PIK3CG2.19902440
17TTN2.18082481
18PDGFRA2.08017547
19CSK1.96224149
20MAP2K31.93112490
21MAP4K11.87673423
22PRKD21.83266513
23DAPK21.80609381
24MAPKAPK31.71645389
25MAP3K131.71237634
26ADRBK21.68725807
27TRPM71.68445330
28SYK1.63364425
29PIM21.63136670
30LATS21.60038166
31IKBKB1.58501689
32MAPK121.52793046
33EPHB11.52367256
34IRAK31.43990046
35DYRK1B1.41616041
36MAP3K141.39644418
37CDK71.39158958
38YES11.38752514
39TEC1.36251728
40CDC42BPA1.35551064
41TBK11.33555262
42TAOK31.31380287
43CDK121.30726201
44BLK1.30335460
45PRPF4B1.30011760
46AKT31.28890632
47IRAK41.26123444
48MAP4K21.20826859
49DAPK11.20505685
50MAP2K61.16504190
51RPS6KL11.12921995
52RPS6KC11.12921995
53DMPK1.12389871
54TIE11.10641711
55BTK1.07839299
56STK391.06413409
57OBSCN1.04005133
58TLK11.03379993
59TRIB31.00365168
60GSK3A0.98692288
61NEK90.98523287
62TNK20.97009194
63EPHA20.95662906
64MARK30.94300526
65RPS6KA60.93193375
66ACVR1B0.91025988
67CDK60.89527563
68PIM10.88803810
69MAP3K10.88599789
70KIT0.87576279
71TAOK10.86080741
72MAP3K70.84384753
73BMPR20.83274115
74MST40.81638634
75MET0.81539950
76LYN0.80863891
77MTOR0.80167544
78ZAP700.79327169
79MUSK0.79323735
80FGFR30.79022940
81IRAK10.78639038
82CAMK2D0.78249302
83CSF1R0.78051735
84EIF2AK30.75616554
85GRK10.74870653
86PRKD10.72463188
87NEK10.72246660
88DAPK30.71677899
89PRKAA10.70805629
90TGFBR20.70750731
91ARAF0.70191817
92FES0.69842359
93MAP3K30.69803095
94HCK0.68878415
95BCKDK0.68026902
96MYLK0.65671464
97FGFR20.64632662
98CHEK20.64555327
99RPS6KB20.63941914
100PDK10.62672363
101PDGFRB0.61768764
102FER0.60290352
103JAK10.59355866
104MAP3K100.58929219
105IKBKE0.58346558
106STK40.58001950
107PAK60.56094450
108PKN20.55708447
109PRKCQ0.54896200
110ALK0.54710338
111PTK20.53930028
112LMTK20.52224293
113ROCK20.52195643
114PDPK10.52160451
115RPS6KA10.52144683
116MAPK40.51856414
117JAK30.51611532
118ITK0.50631148
119MAPK110.49928336
120PLK10.48639369
121MAPK70.48605159
122PAK40.47038616
123GRK50.46682477
124MOS0.46087925
125RIPK10.45711813
126MAP2K10.44988081
127KDR0.44074219
128EGFR0.44017575
129EPHA30.43476620
130TXK0.43327748
131TYK20.42857811
132INSRR0.42111954
133CCNB10.41743028
134STK110.40809096
135CHUK0.40618295
136TAOK20.40592039
137CAMK2G0.40220028
138CAMK2A0.39592722
139PAK10.39087528
140SIK30.37060362
141PRKAA20.36400691
142LCK0.36114701
143LIMK10.35895068
144CAMK2B0.35819090
145NLK0.35663142
146EPHB20.35593916
147PAK20.35302805
148STK30.33482602
149PKN10.32895183
150MAPK10.32753025
151ILK0.32362975
152CDK20.31547348
153MAPK100.30551855
154AURKA0.29409106
155INSR0.28083770
156AKT20.27612930
157DYRK20.25615674
158NTRK10.25053107
159PAK30.24453656
160HIPK20.24160151
161MAPKAPK20.23200662
162CDK140.22754417
163PDK20.22529482
164CSNK1G10.22131756
165CDK150.21922870
166CDK11A0.21380167
167ROCK10.20671293
168PRKACB0.19493808
169CSNK2A10.19454589
170PTK2B0.18690870
171RPS6KA30.17491912
172SGK10.16976306
173MARK20.16805378
174PRKCD0.15917312

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.55382830
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.58892992
3Type I diabetes mellitus_Homo sapiens_hsa049403.29372130
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.23240403
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.81456742
6Mismatch repair_Homo sapiens_hsa034302.79135528
7Base excision repair_Homo sapiens_hsa034102.67789398
8Asthma_Homo sapiens_hsa053102.56588007
9Allograft rejection_Homo sapiens_hsa053302.35018541
10Notch signaling pathway_Homo sapiens_hsa043302.33173275
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32309116
12Cardiac muscle contraction_Homo sapiens_hsa042602.27291657
13Arginine and proline metabolism_Homo sapiens_hsa003302.10433670
14Adherens junction_Homo sapiens_hsa045202.10209488
15Hedgehog signaling pathway_Homo sapiens_hsa043402.08987619
16Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96408301
17Dilated cardiomyopathy_Homo sapiens_hsa054141.95901430
18Hippo signaling pathway_Homo sapiens_hsa043901.94830063
19Rheumatoid arthritis_Homo sapiens_hsa053231.94555391
20Autoimmune thyroid disease_Homo sapiens_hsa053201.91408329
21Graft-versus-host disease_Homo sapiens_hsa053321.89486403
22mTOR signaling pathway_Homo sapiens_hsa041501.86676400
23Platelet activation_Homo sapiens_hsa046111.86390886
24Collecting duct acid secretion_Homo sapiens_hsa049661.83589281
25Viral myocarditis_Homo sapiens_hsa054161.81774473
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71757401
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70367925
28Primary immunodeficiency_Homo sapiens_hsa053401.67626953
29DNA replication_Homo sapiens_hsa030301.67610470
30Fatty acid metabolism_Homo sapiens_hsa012121.67234881
31Butanoate metabolism_Homo sapiens_hsa006501.62110339
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60359012
33Insulin secretion_Homo sapiens_hsa049111.59099148
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57749919
35Sulfur metabolism_Homo sapiens_hsa009201.57276374
36Tight junction_Homo sapiens_hsa045301.57044060
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56217892
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55740350
39Other glycan degradation_Homo sapiens_hsa005111.51954314
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.45833788
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44531965
42B cell receptor signaling pathway_Homo sapiens_hsa046621.44322478
43Dorso-ventral axis formation_Homo sapiens_hsa043201.44153423
44VEGF signaling pathway_Homo sapiens_hsa043701.39910008
45Leishmaniasis_Homo sapiens_hsa051401.36470727
46Parkinsons disease_Homo sapiens_hsa050121.33530321
47TGF-beta signaling pathway_Homo sapiens_hsa043501.33493193
48Oxidative phosphorylation_Homo sapiens_hsa001901.32867683
49Fatty acid elongation_Homo sapiens_hsa000621.30373042
50mRNA surveillance pathway_Homo sapiens_hsa030151.29792499
51Biosynthesis of amino acids_Homo sapiens_hsa012301.29751680
52Basal cell carcinoma_Homo sapiens_hsa052171.27025697
53Shigellosis_Homo sapiens_hsa051311.26681507
54Type II diabetes mellitus_Homo sapiens_hsa049301.26318173
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25210138
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23328775
57Steroid biosynthesis_Homo sapiens_hsa001001.22962433
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.22681639
59Osteoclast differentiation_Homo sapiens_hsa043801.22144819
60Insulin resistance_Homo sapiens_hsa049311.20685282
61Adipocytokine signaling pathway_Homo sapiens_hsa049201.17955607
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16970244
63* Focal adhesion_Homo sapiens_hsa045101.16559237
64Hematopoietic cell lineage_Homo sapiens_hsa046401.16257542
65Regulation of autophagy_Homo sapiens_hsa041401.13700795
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13657089
67RNA transport_Homo sapiens_hsa030131.13401110
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11196556
69Bladder cancer_Homo sapiens_hsa052191.10863971
70Nucleotide excision repair_Homo sapiens_hsa034201.09387817
71Staphylococcus aureus infection_Homo sapiens_hsa051501.08322317
72MicroRNAs in cancer_Homo sapiens_hsa052061.05751822
73Circadian rhythm_Homo sapiens_hsa047101.05150712
74Huntingtons disease_Homo sapiens_hsa050161.04267726
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04261538
76Small cell lung cancer_Homo sapiens_hsa052221.03383273
77Spliceosome_Homo sapiens_hsa030401.01509321
78Tryptophan metabolism_Homo sapiens_hsa003801.00748239
79Wnt signaling pathway_Homo sapiens_hsa043101.00210357
80p53 signaling pathway_Homo sapiens_hsa041151.00188450
81Proteoglycans in cancer_Homo sapiens_hsa052050.99040143
82ECM-receptor interaction_Homo sapiens_hsa045120.98570046
83Tuberculosis_Homo sapiens_hsa051520.98231988
84Glucagon signaling pathway_Homo sapiens_hsa049220.97047155
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.96371248
86Lysine degradation_Homo sapiens_hsa003100.95890980
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93108501
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92542724
89Nitrogen metabolism_Homo sapiens_hsa009100.92537202
90Pentose phosphate pathway_Homo sapiens_hsa000300.91591167
91Axon guidance_Homo sapiens_hsa043600.90589903
92Sulfur relay system_Homo sapiens_hsa041220.88967906
93Fructose and mannose metabolism_Homo sapiens_hsa000510.87336896
94Oxytocin signaling pathway_Homo sapiens_hsa049210.87229230
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86368177
96Calcium signaling pathway_Homo sapiens_hsa040200.86296999
97Alzheimers disease_Homo sapiens_hsa050100.85710012
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84661908
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84418898
100Fanconi anemia pathway_Homo sapiens_hsa034600.83664182
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82387204
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82256538
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.78991911
104Gap junction_Homo sapiens_hsa045400.78737426
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78731728
106Renin secretion_Homo sapiens_hsa049240.78239616
107Choline metabolism in cancer_Homo sapiens_hsa052310.77659748
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77061122
109Homologous recombination_Homo sapiens_hsa034400.75991645
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74886846
111Renal cell carcinoma_Homo sapiens_hsa052110.74837342
112HIF-1 signaling pathway_Homo sapiens_hsa040660.74458529
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.74419281
114Systemic lupus erythematosus_Homo sapiens_hsa053220.74342736
115Endocytosis_Homo sapiens_hsa041440.73081477
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72684524
117Chronic myeloid leukemia_Homo sapiens_hsa052200.72558834
118Phagosome_Homo sapiens_hsa041450.72521589
119Oocyte meiosis_Homo sapiens_hsa041140.71122271
120AMPK signaling pathway_Homo sapiens_hsa041520.70088051
121ABC transporters_Homo sapiens_hsa020100.67429768
122Toxoplasmosis_Homo sapiens_hsa051450.67404659
123Cell cycle_Homo sapiens_hsa041100.67369229
124ErbB signaling pathway_Homo sapiens_hsa040120.66790526
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66584812
126Insulin signaling pathway_Homo sapiens_hsa049100.65493263
127Malaria_Homo sapiens_hsa051440.64955759
128Ovarian steroidogenesis_Homo sapiens_hsa049130.62073122
129Long-term depression_Homo sapiens_hsa047300.61582359
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61425896
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60501368
132Lysosome_Homo sapiens_hsa041420.60371459
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60361722
134MAPK signaling pathway_Homo sapiens_hsa040100.59867682
135Legionellosis_Homo sapiens_hsa051340.59571368
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58880690
137Carbon metabolism_Homo sapiens_hsa012000.57348657
138Colorectal cancer_Homo sapiens_hsa052100.56313010
139Acute myeloid leukemia_Homo sapiens_hsa052210.56083445
140TNF signaling pathway_Homo sapiens_hsa046680.55838915
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55416769
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53401210
143Antigen processing and presentation_Homo sapiens_hsa046120.53102208
144Pathways in cancer_Homo sapiens_hsa052000.52894886
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52538052
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51970594
147RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51361382
148Fatty acid degradation_Homo sapiens_hsa000710.51262689
149Phototransduction_Homo sapiens_hsa047440.50837348
150Chemokine signaling pathway_Homo sapiens_hsa040620.48893200
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48813763
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48016234
153Rap1 signaling pathway_Homo sapiens_hsa040150.47823359
154Salmonella infection_Homo sapiens_hsa051320.46384530
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.44982738
156Viral carcinogenesis_Homo sapiens_hsa052030.44013553
157Ras signaling pathway_Homo sapiens_hsa040140.42977198
158Amoebiasis_Homo sapiens_hsa051460.42689661
159Jak-STAT signaling pathway_Homo sapiens_hsa046300.42669057
160Melanoma_Homo sapiens_hsa052180.42398674
161Influenza A_Homo sapiens_hsa051640.40676026
162Galactose metabolism_Homo sapiens_hsa000520.40567699
163Starch and sucrose metabolism_Homo sapiens_hsa005000.40474320
164Synaptic vesicle cycle_Homo sapiens_hsa047210.40407166
165Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40248025
166Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39991837
167Herpes simplex infection_Homo sapiens_hsa051680.39630192
168Arachidonic acid metabolism_Homo sapiens_hsa005900.39273087
169African trypanosomiasis_Homo sapiens_hsa051430.38334788
170Prostate cancer_Homo sapiens_hsa052150.38089886
171Peroxisome_Homo sapiens_hsa041460.37453192
172Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37240000
173T cell receptor signaling pathway_Homo sapiens_hsa046600.36824910
174GnRH signaling pathway_Homo sapiens_hsa049120.36554692
175Propanoate metabolism_Homo sapiens_hsa006400.35300576
176AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34886432
177Serotonergic synapse_Homo sapiens_hsa047260.33867524
178Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32414879
179Phospholipase D signaling pathway_Homo sapiens_hsa040720.30894476

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