PARVA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the parvin family of actin-binding proteins. Parvins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. The encoded protein is part of the integrin-linked kinase signaling complex and plays a role in cell adhesion, motility and survival. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1extracellular fibril organization (GO:0043206)4.21558511
2type B pancreatic cell proliferation (GO:0044342)4.06340533
3extracellular matrix assembly (GO:0085029)3.78193172
4glomerular basement membrane development (GO:0032836)3.70022660
5collagen fibril organization (GO:0030199)3.69504625
6fibril organization (GO:0097435)3.55750695
7chondrocyte proliferation (GO:0035988)3.52224644
8regulation of integrin-mediated signaling pathway (GO:2001044)3.42017011
9hemidesmosome assembly (GO:0031581)3.35970497
10neuron projection extension involved in neuron projection guidance (GO:1902284)3.34811363
11axon extension involved in axon guidance (GO:0048846)3.34811363
12substrate-dependent cell migration (GO:0006929)3.34206445
13negative regulation of smooth muscle cell migration (GO:0014912)3.33352268
14protein heterotrimerization (GO:0070208)3.25151532
15negative regulation of fatty acid transport (GO:2000192)3.24910093
16sequestering of extracellular ligand from receptor (GO:0035581)3.23258451
17cell-substrate junction assembly (GO:0007044)3.18227569
18phenol-containing compound catabolic process (GO:0019336)3.16292820
19smooth muscle tissue development (GO:0048745)3.16208273
20cell adhesion mediated by integrin (GO:0033627)3.11817329
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11126574
22glomerular visceral epithelial cell development (GO:0072015)3.09385664
23virion attachment to host cell (GO:0019062)3.08356526
24adhesion of symbiont to host cell (GO:0044650)3.08356526
25barbed-end actin filament capping (GO:0051016)3.05317140
26actin filament depolymerization (GO:0030042)3.03265366
27renal filtration (GO:0097205)2.99112690
28blood vessel maturation (GO:0001955)2.98785113
29paraxial mesoderm development (GO:0048339)2.98688974
30positive regulation of fatty acid beta-oxidation (GO:0032000)2.97594872
31positive regulation of osteoblast proliferation (GO:0033690)2.94397062
32extracellular negative regulation of signal transduction (GO:1900116)2.94067351
33extracellular regulation of signal transduction (GO:1900115)2.94067351
34retina vasculature morphogenesis in camera-type eye (GO:0061299)2.93820837
35extracellular matrix organization (GO:0030198)2.91302048
36ganglion development (GO:0061548)2.91023102
37extracellular structure organization (GO:0043062)2.90125952
38glomerular epithelial cell development (GO:0072310)2.89975758
39positive regulation of blood vessel endothelial cell migration (GO:0043536)2.88728806
40vascular endothelial growth factor signaling pathway (GO:0038084)2.85060555
41basement membrane organization (GO:0071711)2.84957322
42regulation of secondary heart field cardioblast proliferation (GO:0003266)2.84849615
43regulation of cardioblast proliferation (GO:0003264)2.84849615
44metanephric mesenchyme development (GO:0072075)2.79804170
45keratan sulfate catabolic process (GO:0042340)2.79698334
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78277906
47endodermal cell differentiation (GO:0035987)2.77854978
48negative regulation of axon extension involved in axon guidance (GO:0048843)2.76068507
49cellular response to vitamin D (GO:0071305)2.74311911
50* substrate adhesion-dependent cell spreading (GO:0034446)2.74062807
51kidney mesenchyme development (GO:0072074)2.73742698
52dermatan sulfate biosynthetic process (GO:0030208)2.72584235
53chondrocyte development (GO:0002063)2.71858021
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.70862534
55adhesion of symbiont to host (GO:0044406)2.66533932
56negative regulation of fibrinolysis (GO:0051918)2.65540537
57wound healing, spreading of cells (GO:0044319)2.65479852
58pericardium development (GO:0060039)2.64057317
59heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.63794379
60plasma membrane repair (GO:0001778)2.63278044
61desmosome organization (GO:0002934)2.62790767
62hypotonic response (GO:0006971)2.62668664
63epoxygenase P450 pathway (GO:0019373)2.62247119
64dermatan sulfate metabolic process (GO:0030205)2.62217025
65glomerular filtration (GO:0003094)2.62120735
66Golgi transport vesicle coating (GO:0048200)2.59916454
67COPI coating of Golgi vesicle (GO:0048205)2.59916454
68stress fiber assembly (GO:0043149)2.59772765
69regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59310143
70cell migration involved in sprouting angiogenesis (GO:0002042)2.58825675
71endocardial cushion development (GO:0003197)2.58247550
72regulation of chondrocyte differentiation (GO:0032330)2.57960128
73mesodermal cell differentiation (GO:0048333)2.57043142
74bone trabecula formation (GO:0060346)2.56547241
75vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55612968
76adherens junction assembly (GO:0034333)2.55452335
77regulation of cartilage development (GO:0061035)2.55082782
78negative regulation of BMP signaling pathway (GO:0030514)2.54221448
79peptidyl-proline hydroxylation (GO:0019511)2.53951337
80dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53538769
81toxin metabolic process (GO:0009404)2.53227930
82positive regulation of endothelial cell apoptotic process (GO:2000353)2.52537438
83insulin-like growth factor receptor signaling pathway (GO:0048009)2.52131557
84coronary vasculature morphogenesis (GO:0060977)2.50880702
85regulation of extracellular matrix disassembly (GO:0010715)2.49621968
86collagen metabolic process (GO:0032963)2.48366358
87glucuronate metabolic process (GO:0019585)2.48089767
88uronic acid metabolic process (GO:0006063)2.48089767
89positive regulation of fatty acid oxidation (GO:0046321)2.47923585
90dopaminergic neuron differentiation (GO:0071542)2.47129856
91regulation of osteoblast proliferation (GO:0033688)2.46399757
92regulation of fatty acid beta-oxidation (GO:0031998)2.46160700
93negative regulation of embryonic development (GO:0045992)2.45941439
94hippo signaling (GO:0035329)2.44862504
95multicellular organismal macromolecule metabolic process (GO:0044259)2.44654756
96skin morphogenesis (GO:0043589)2.43196020
97mesenchymal-epithelial cell signaling (GO:0060638)2.41874910
98apoptotic cell clearance (GO:0043277)2.41232616
99cell migration involved in heart development (GO:0060973)2.40528545
100collagen catabolic process (GO:0030574)2.39666682
101maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39134430
102positive regulation of glycogen biosynthetic process (GO:0045725)2.38855006
103cellular glucuronidation (GO:0052695)2.38785356
104regulation of axon extension involved in axon guidance (GO:0048841)2.38779009
105multicellular organismal metabolic process (GO:0044236)2.37086675
106outer ear morphogenesis (GO:0042473)2.36211874
107midgut development (GO:0007494)2.35751295
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.33048099
109L-phenylalanine catabolic process (GO:0006559)2.33048099
110epithelial cell-cell adhesion (GO:0090136)2.32907435
111lung vasculature development (GO:0060426)2.32337172
112multicellular organismal catabolic process (GO:0044243)2.31035757
113regulation of axon guidance (GO:1902667)2.29709272
114lymphangiogenesis (GO:0001946)2.29447511
115negative regulation of chondrocyte differentiation (GO:0032331)2.28329109
116protein retention in ER lumen (GO:0006621)2.27706062
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.27125450
118L-phenylalanine metabolic process (GO:0006558)2.27125450
119regulation of plasminogen activation (GO:0010755)2.26724444
120extracellular matrix disassembly (GO:0022617)2.26416481
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.22116683
122regulation of fibrinolysis (GO:0051917)2.22112744
123sulfur amino acid catabolic process (GO:0000098)2.22012941
124endothelial cell morphogenesis (GO:0001886)2.21658671
125wound healing, spreading of epidermal cells (GO:0035313)2.21335182
126peptidyl-glutamic acid carboxylation (GO:0017187)2.19638216
127protein carboxylation (GO:0018214)2.19638216
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.19548454
129regulation of heart morphogenesis (GO:2000826)2.17890673
130alpha-linolenic acid metabolic process (GO:0036109)2.17419971
131negative regulation of cartilage development (GO:0061037)2.16335551
132cellular response to vitamin (GO:0071295)2.15648561
133glomerulus development (GO:0032835)2.15400726
134negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.13748177
135positive regulation of cartilage development (GO:0061036)2.13065914
136cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.12670361
137protein localization to cell surface (GO:0034394)2.12658040
138endocardial cushion morphogenesis (GO:0003203)2.11925052
139negative regulation of catenin import into nucleus (GO:0035414)2.10294085
140regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.10281352
141regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.09951287
142regulation of tight junction assembly (GO:2000810)2.09209395
143mesenchyme morphogenesis (GO:0072132)2.09120919
144regulation of organ formation (GO:0003156)2.08975987
145positive regulation of glycogen metabolic process (GO:0070875)2.08546930
146exocrine pancreas development (GO:0031017)2.07515270
147sympathetic nervous system development (GO:0048485)2.07011018
1484-hydroxyproline metabolic process (GO:0019471)2.06937929
149regulation of cholesterol homeostasis (GO:2000188)2.06490951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.32530028
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15394824
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.97218963
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.85338679
5CLOCK_20551151_ChIP-Seq_293T_Human2.48725628
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24917176
7* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22071229
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.18989349
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17793476
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.08076054
11LXR_22158963_ChIP-Seq_LIVER_Mouse1.98642093
12EED_16625203_ChIP-ChIP_MESCs_Mouse1.98411747
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.97514309
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92295116
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91248243
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91248243
17* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83923745
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.82878643
19ESR2_21235772_ChIP-Seq_MCF-7_Human1.81100061
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.80043092
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75950316
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75128712
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71751140
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71316843
25CJUN_26792858_Chip-Seq_BT549_Human1.70577629
26* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70059580
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65063144
28* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63384241
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.62763146
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.62763146
31* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.60985009
32* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58849169
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.56187613
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52713747
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47694151
36JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44197443
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.41652480
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38833477
39* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36784586
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.36594752
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36287218
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35635201
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34839333
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34353781
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34229667
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32652212
47* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.32304061
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32029311
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.31050471
50ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.30898840
51TP53_18474530_ChIP-ChIP_U2OS_Human1.30080207
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29940161
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.29344513
54SOX2_20726797_ChIP-Seq_SW620_Human1.28556149
55TP53_22127205_ChIP-Seq_IMR90_Human1.28143756
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27596211
57SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27488304
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26940106
59* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26023954
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25684441
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22879370
62* TP53_23651856_ChIP-Seq_MEFs_Mouse1.22327898
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.22300760
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21878165
65AHR_22903824_ChIP-Seq_MCF-7_Human1.19069600
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18844354
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18252314
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.18232958
69SA1_22415368_ChIP-Seq_MEFs_Mouse1.17203356
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16366886
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.16085944
72* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15906886
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15417307
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15218267
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15168057
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12776812
77DROSHA_22980978_ChIP-Seq_HELA_Human1.12553276
78GBX2_23144817_ChIP-Seq_PC3_Human1.11933844
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11648129
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11554521
81* ISL1_27105846_Chip-Seq_CPCs_Mouse1.11334269
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10728546
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08826966
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08500303
85* BRD4_25478319_ChIP-Seq_HGPS_Human1.08293479
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.08106206
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.08106206
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07765215
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07741989
90* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07632230
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.06315195
92HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06105850
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05258681
94BCAT_22108803_ChIP-Seq_LS180_Human1.04466629
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.04302241
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.03950946
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.03852754
98* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02862915
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.01941751
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99398428
101* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98670308
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.97815827
103CDX2_20551321_ChIP-Seq_CACO-2_Human0.96748149
104* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96237648
105* TP63_23658742_ChIP-Seq_EP156T_Human0.95772459
106TP53_16413492_ChIP-PET_HCT116_Human0.94096942
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92187535
108* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92019780
109AR_21572438_ChIP-Seq_LNCaP_Human0.91869512
110* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91743194
111* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91173629
112KDM2B_26808549_Chip-Seq_K562_Human0.90448048
113TET1_21490601_ChIP-Seq_MESCs_Mouse0.90329623
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88850287
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88575507
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88368024
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88368024
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.88083276
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87826782
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87664517
121NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87498458
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87335295
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86330868
124PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.85976992
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85768475
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85577286
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.84354387
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83760764
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83684688
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82344767

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.19702347
2MP0004272_abnormal_basement_membrane3.56953858
3MP0005503_abnormal_tendon_morphology3.56090419
4MP0005275_abnormal_skin_tensile3.35141765
5MP0003705_abnormal_hypodermis_morpholog3.19251725
6MP0005623_abnormal_meninges_morphology2.68059837
7MP0009384_cardiac_valve_regurgitation2.58643751
8MP0003950_abnormal_plasma_membrane2.38795304
9MP0001958_emphysema2.36818660
10* MP0003279_aneurysm2.15242925
11MP0010368_abnormal_lymphatic_system2.14906037
12MP0002139_abnormal_hepatobiliary_system2.02885852
13MP0010030_abnormal_orbit_morphology1.96042970
14MP0009053_abnormal_anal_canal1.92782961
15MP0000013_abnormal_adipose_tissue1.88614632
16MP0010386_abnormal_urinary_bladder1.87238996
17MP0000534_abnormal_ureter_morphology1.82108840
18MP0003566_abnormal_cell_adhesion1.76181234
19MP0000537_abnormal_urethra_morphology1.71902557
20MP0002295_abnormal_pulmonary_circulatio1.70251167
21MP0005360_urolithiasis1.70184622
22MP0005085_abnormal_gallbladder_physiolo1.68116524
23MP0005365_abnormal_bile_salt1.67308915
24* MP0003942_abnormal_urinary_system1.66582125
25MP0003252_abnormal_bile_duct1.66143154
26MP0008875_abnormal_xenobiotic_pharmacok1.62870371
27MP0002896_abnormal_bone_mineralization1.59491124
28MP0005171_absent_coat_pigmentation1.55242518
29MP0009780_abnormal_chondrocyte_physiolo1.54240924
30MP0003385_abnormal_body_wall1.52710493
31MP0005508_abnormal_skeleton_morphology1.51512844
32MP0003283_abnormal_digestive_organ1.51191217
33MP0009250_abnormal_appendicular_skeleto1.46981048
34MP0006054_spinal_hemorrhage1.43353640
35MP0001879_abnormal_lymphatic_vessel1.38538457
36MP0010352_gastrointestinal_tract_polyps1.36135258
37MP0002108_abnormal_muscle_morphology1.34420181
38MP0001299_abnormal_eye_distance/1.34172008
39MP0005257_abnormal_intraocular_pressure1.33317343
40MP0003091_abnormal_cell_migration1.27873868
41MP0002060_abnormal_skin_morphology1.26104606
42MP0001243_abnormal_dermal_layer1.25801052
43MP0002168_other_aberrant_phenotype1.21896415
44MP0004858_abnormal_nervous_system1.20577169
45MP0005248_abnormal_Harderian_gland1.19107597
46MP0000749_muscle_degeneration1.17803938
47MP0000538_abnormal_urinary_bladder1.17046144
48MP0000163_abnormal_cartilage_morphology1.15058708
49MP0005083_abnormal_biliary_tract1.12799020
50MP0000003_abnormal_adipose_tissue1.09771996
51MP0002877_abnormal_melanocyte_morpholog1.08234424
52MP0003045_fibrosis1.07838896
53MP0005197_abnormal_uvea_morphology1.06933201
54MP0002233_abnormal_nose_morphology1.06360026
55MP0001270_distended_abdomen1.06196960
56MP0003941_abnormal_skin_development1.05458432
57MP0002837_dystrophic_cardiac_calcinosis1.04115083
58MP0003115_abnormal_respiratory_system1.04092970
59MP0001756_abnormal_urination1.01993430
60MP0005023_abnormal_wound_healing0.99808767
61MP0000762_abnormal_tongue_morphology0.99331342
62MP0003122_maternal_imprinting0.99246073
63MP0000049_abnormal_middle_ear0.99210890
64MP0002282_abnormal_trachea_morphology0.96895945
65MP0000462_abnormal_digestive_system0.96788866
66MP0006138_congestive_heart_failure0.96115344
67MP0004084_abnormal_cardiac_muscle0.96020803
68MP0005670_abnormal_white_adipose0.95884713
69* MP0000767_abnormal_smooth_muscle0.95706996
70MP0001348_abnormal_lacrimal_gland0.92840973
71MP0005164_abnormal_response_to0.92498240
72MP0010329_abnormal_lipoprotein_level0.91003462
73MP0002932_abnormal_joint_morphology0.90991021
74MP0000759_abnormal_skeletal_muscle0.90543396
75MP0005187_abnormal_penis_morphology0.89609687
76MP0002115_abnormal_skeleton_extremities0.89512984
77MP0003195_calcinosis0.89336243
78MP0002822_catalepsy0.88965787
79MP0005332_abnormal_amino_acid0.88643339
80MP0003937_abnormal_limbs/digits/tail_de0.86695007
81MP0005595_abnormal_vascular_smooth0.86383422
82MP0005220_abnormal_exocrine_pancreas0.86246799
83MP0005390_skeleton_phenotype0.84879261
84MP0000428_abnormal_craniofacial_morphol0.84263566
85MP0001849_ear_inflammation0.83284979
86MP0004134_abnormal_chest_morphology0.82546967
87MP0000751_myopathy0.81704743
88MP0001542_abnormal_bone_strength0.80847663
89MP0003755_abnormal_palate_morphology0.80692411
90MP0000750_abnormal_muscle_regeneration0.80422276
91MP0002234_abnormal_pharynx_morphology0.79771916
92MP0002697_abnormal_eye_size0.79755856
93MP0000733_abnormal_muscle_development0.78697688
94MP0000432_abnormal_head_morphology0.78356082
95MP0005375_adipose_tissue_phenotype0.78307466
96MP0005165_increased_susceptibility_to0.77892118
97MP0003935_abnormal_craniofacial_develop0.77498093
98* MP0001614_abnormal_blood_vessel0.76549059
99MP0004233_abnormal_muscle_weight0.75928564
100* MP0002128_abnormal_blood_circulation0.75094196
101MP0002249_abnormal_larynx_morphology0.74871139
102MP0000516_abnormal_urinary_system0.74776531
103MP0005367_renal/urinary_system_phenotyp0.74776531
104MP0008789_abnormal_olfactory_epithelium0.72347250
105MP0001177_atelectasis0.70072362
106MP0004087_abnormal_muscle_fiber0.69531024
107MP0004036_abnormal_muscle_relaxation0.68817580
108MP0002113_abnormal_skeleton_development0.68665911
109MP0005193_abnormal_anterior_eye0.68514127
110MP0005388_respiratory_system_phenotype0.67810966
111MP0002133_abnormal_respiratory_system0.67810966
112MP0005409_darkened_coat_color0.66897141
113MP0005620_abnormal_muscle_contractility0.66466258
114MP0009643_abnormal_urine_homeostasis0.66325333
115MP0000467_abnormal_esophagus_morphology0.66034596
116MP0002909_abnormal_adrenal_gland0.64551313
117MP0002116_abnormal_craniofacial_bone0.64499853
118MP0001666_abnormal_nutrient_absorption0.63066191
119MP0005394_taste/olfaction_phenotype0.62554409
120MP0005499_abnormal_olfactory_system0.62554409
121MP0002972_abnormal_cardiac_muscle0.62428301
122MP0004130_abnormal_muscle_cell0.62065205
123MP0001661_extended_life_span0.61133438
124MP0001915_intracranial_hemorrhage0.60177844
125MP0003828_pulmonary_edema0.59562826
126* MP0002925_abnormal_cardiovascular_devel0.59415253
127MP0005330_cardiomyopathy0.58018011
128MP0002177_abnormal_outer_ear0.56058431
129MP0002933_joint_inflammation0.55916986
130MP0003191_abnormal_cellular_cholesterol0.55622712
131MP0001175_abnormal_lung_morphology0.55113451
132MP0002114_abnormal_axial_skeleton0.54872800
133MP0008775_abnormal_heart_ventricle0.53892494
134MP0003868_abnormal_feces_composition0.53110466
135MP0002109_abnormal_limb_morphology0.52543271

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.75990982
2Premature rupture of membranes (HP:0001788)5.56631650
3Aortic dissection (HP:0002647)3.84771822
4Atrophic scars (HP:0001075)3.70460717
5Broad metatarsal (HP:0001783)3.69037255
6Shallow orbits (HP:0000586)3.64695038
7Aortic aneurysm (HP:0004942)3.56975018
8Ankle contracture (HP:0006466)3.26530874
9Cerebral aneurysm (HP:0004944)3.25309979
10Fragile skin (HP:0001030)3.01404462
11Bladder diverticulum (HP:0000015)2.97611321
12Soft skin (HP:0000977)2.93230099
13Abnormality of dentin (HP:0010299)2.88975672
14Spondylolisthesis (HP:0003302)2.86500167
15Deep venous thrombosis (HP:0002625)2.84365724
16Peritonitis (HP:0002586)2.83261169
17Aortic regurgitation (HP:0001659)2.79747177
18Slender build (HP:0001533)2.74187118
19Osteolytic defects of the hand bones (HP:0009699)2.68564979
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.68564979
21Dilatation of the ascending aorta (HP:0005111)2.67343306
22Mitral valve prolapse (HP:0001634)2.61718287
23Spinal rigidity (HP:0003306)2.61198423
24Right ventricular cardiomyopathy (HP:0011663)2.56958462
25Wormian bones (HP:0002645)2.52320386
26Aneurysm (HP:0002617)2.49709372
27Cervical subluxation (HP:0003308)2.47312219
28Neonatal short-limb short stature (HP:0008921)2.47055328
29Mitral regurgitation (HP:0001653)2.45746846
30Blue sclerae (HP:0000592)2.42863527
31Abnormality of the acetabulum (HP:0003170)2.42414484
32Vascular tortuosity (HP:0004948)2.38424552
33Increased connective tissue (HP:0009025)2.37935268
34Lymphangioma (HP:0100764)2.37498085
35Focal segmental glomerulosclerosis (HP:0000097)2.37104309
36Overgrowth (HP:0001548)2.33757699
37Aortic valve stenosis (HP:0001650)2.29972279
38Facial shape deformation (HP:0011334)2.29765722
39Potter facies (HP:0002009)2.29765722
40Follicular hyperkeratosis (HP:0007502)2.25026858
41Wrist flexion contracture (HP:0001239)2.23873659
42Type 1 muscle fiber predominance (HP:0003803)2.21314777
43Long toe (HP:0010511)2.21187645
44Turricephaly (HP:0000262)2.20374523
45Absent frontal sinuses (HP:0002688)2.19527495
46Round ear (HP:0100830)2.19377288
47Coronal craniosynostosis (HP:0004440)2.17096048
48Buphthalmos (HP:0000557)2.16502508
49Abnormality of skeletal muscle fiber size (HP:0012084)2.15739415
50Hyperextensible skin (HP:0000974)2.14177466
51Hypoplasia of the iris (HP:0007676)2.14132997
52Morphological abnormality of the middle ear (HP:0008609)2.13755394
53Joint stiffness (HP:0001387)2.13459284
54Bronchomalacia (HP:0002780)2.12976938
55Arterial tortuosity (HP:0005116)2.12386696
56Wide anterior fontanel (HP:0000260)2.12001540
57Natal tooth (HP:0000695)2.11568335
58Ectopia lentis (HP:0001083)2.04681989
59Biconcave vertebral bodies (HP:0004586)2.04594207
60Tarsal synostosis (HP:0008368)2.03522371
61Deviation of the hallux (HP:0010051)2.03174251
62Mesangial abnormality (HP:0001966)2.02598265
63Infantile muscular hypotonia (HP:0008947)2.01633525
64Knee flexion contracture (HP:0006380)1.99637978
65Short hallux (HP:0010109)1.98935393
66Mesomelia (HP:0003027)1.98693507
67Distal upper limb amyotrophy (HP:0007149)1.98133295
68Upper limb amyotrophy (HP:0009129)1.98133295
69Bowel diverticulosis (HP:0005222)1.96548598
70Breech presentation (HP:0001623)1.96296560
71Aplasia involving bones of the extremities (HP:0009825)1.95794689
72Aplasia involving bones of the upper limbs (HP:0009823)1.95794689
73Aplasia of the phalanges of the hand (HP:0009802)1.95794689
74Enlarged penis (HP:0000040)1.95669503
75Glomerulosclerosis (HP:0000096)1.95531052
76Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95272813
77Camptodactyly of toe (HP:0001836)1.94415270
78Mildly elevated creatine phosphokinase (HP:0008180)1.94270585
79Hypothermia (HP:0002045)1.92100516
80Scapular winging (HP:0003691)1.91072595
81Xanthomatosis (HP:0000991)1.90332311
82Vertebral compression fractures (HP:0002953)1.90085265
83Thin bony cortex (HP:0002753)1.89598718
84Generalized amyotrophy (HP:0003700)1.89223463
85Hallux valgus (HP:0001822)1.89200882
86Short nail (HP:0001799)1.87864196
87Neonatal hypoglycemia (HP:0001998)1.87103957
88Ovoid vertebral bodies (HP:0003300)1.87015333
89Limited hip movement (HP:0008800)1.86594808
90Hypoventilation (HP:0002791)1.86074989
91Bell-shaped thorax (HP:0001591)1.86010489
92Back pain (HP:0003418)1.85000319
93Mild short stature (HP:0003502)1.84394624
94Inguinal hernia (HP:0000023)1.83814381
95Synostosis involving bones of the feet (HP:0009140)1.82444785
96Synostosis involving bones of the lower limbs (HP:0009138)1.82444785
97Disproportionate tall stature (HP:0001519)1.82309111
98Delayed cranial suture closure (HP:0000270)1.81112717
99Protruding ear (HP:0000411)1.80942125
100Coxa vara (HP:0002812)1.80458992
101Pulmonary artery stenosis (HP:0004415)1.80443339
102Synostosis involving the elbow (HP:0003938)1.80412845
103Humeroradial synostosis (HP:0003041)1.80412845
104Femoral bowing (HP:0002980)1.80264078
105Venous insufficiency (HP:0005293)1.79789031
106Striae distensae (HP:0001065)1.79344945
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.78844808
108Genu recurvatum (HP:0002816)1.78683376
109Osteopenia (HP:0000938)1.77459039
110Congenital glaucoma (HP:0001087)1.77411972
111Venous abnormality (HP:0002624)1.76571605
112Skin nodule (HP:0200036)1.75281674
113Abnormality of glutamine family amino acid metabolism (HP:0010902)1.75240679
114Increased variability in muscle fiber diameter (HP:0003557)1.74493141
115Osteoarthritis (HP:0002758)1.74114446
116Elbow flexion contracture (HP:0002987)1.73760738
117Hip contracture (HP:0003273)1.73742378
118Hypoglycemic coma (HP:0001325)1.73076755
119Redundant skin (HP:0001582)1.73067384
120Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73012219
121Aplasia/Hypoplasia of the hallux (HP:0008362)1.72683601
122Abnormality of the middle phalanges of the toes (HP:0010183)1.72059127
123Mitral stenosis (HP:0001718)1.71083603
124Delayed closure of the anterior fontanelle (HP:0001476)1.70944726
125Ulnar bowing (HP:0003031)1.70826704
126Joint laxity (HP:0001388)1.70597668
127Tibial bowing (HP:0002982)1.70165510
128Abnormality of carpal bone ossification (HP:0006257)1.68448619
129Bradycardia (HP:0001662)1.68364803
130Abnormal delivery (HP:0001787)1.67912220
131Abnormality of the anterior chamber (HP:0000593)1.67773646
132Nonimmune hydrops fetalis (HP:0001790)1.67335003
133Cardiovascular calcification (HP:0011915)1.67253849
134Limb-girdle muscle weakness (HP:0003325)1.66907058
135Abnormality of proline metabolism (HP:0010907)1.66892604
136Hydroxyprolinuria (HP:0003080)1.66892604
137Broad ribs (HP:0000885)1.64593053
138Thin skin (HP:0000963)1.64395393
139Abnormality of skull ossification (HP:0002703)1.64275149
140Hand muscle atrophy (HP:0009130)1.62786936
141Renal duplication (HP:0000075)1.62390349
142Bowed forearm bones (HP:0003956)1.60728598
143Bowing of the arm (HP:0006488)1.60728598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.55715089
2DDR23.19468609
3PDGFRA2.99522074
4LATS12.98182381
5EPHB22.84611432
6SIK12.83775970
7NTRK12.72268382
8TTN2.50240483
9LATS22.40929031
10FER2.35374894
11RIPK12.28089537
12INSRR2.26328440
13MYLK2.14934321
14PTK22.05220113
15ERN12.02476545
16PAK31.95973066
17PKN21.77866249
18FRK1.75972527
19PTK61.67363394
20WNK41.64122795
21STK38L1.51590321
22LMTK21.49688800
23PAK21.47654518
24EPHA31.41757762
25EPHA21.39883338
26TIE11.38803400
27LIMK11.31108247
28MAP3K21.28650132
29MET1.24528253
30DMPK1.18998226
31ABL21.13407978
32ROCK11.12340658
33TESK11.10328609
34PIK3CA1.09250869
35TGFBR21.05074574
36MAPKAPK31.04746948
37ERBB21.04550854
38BMX1.03512769
39TRPM71.03370062
40PDGFRB1.02288636
41PRKD31.01426114
42PTK2B0.99138291
43CAMK1D0.98358650
44MAP3K120.97981003
45NEK90.97611484
46FGFR10.96617992
47CAMK1G0.94645242
48FGFR40.92886509
49ERBB30.90508381
50WNK10.90136993
51ICK0.89627864
52RET0.88891823
53BCKDK0.87811876
54MUSK0.87752258
55CDC42BPA0.85988584
56PAK40.84694877
57MAP3K30.83542418
58MAP3K60.82264586
59LRRK20.79369414
60MST1R0.79178826
61PRKCE0.78839578
62PIK3CG0.77560433
63DAPK30.75236107
64FGFR20.74809653
65* MAP2K10.74267420
66ERBB40.72518563
67MTOR0.69675716
68PIM20.68771205
69ADRBK10.68250905
70STK30.67788418
71STK380.67123488
72EPHB10.66916981
73PRKD10.66366783
74ILK0.64734772
75PRKCH0.63050168
76MAPK70.62801816
77KDR0.61087700
78MAPK150.60683295
79GRK70.60618509
80FLT30.60580908
81ROCK20.59261492
82MELK0.56423817
83PRKG20.55994245
84GSK3A0.55571693
85PAK60.54213221
86STK390.54136716
87CDK80.53673594
88MINK10.52794520
89MAP2K40.51287783
90MAP3K70.50613934
91DYRK1B0.50606090
92MAP2K20.50228244
93IGF1R0.48431490
94INSR0.48193648
95SRC0.48002359
96GRK50.47633621
97CAMK2D0.44910534
98CAMKK10.44629372
99PHKG10.43945199
100PHKG20.43945199
101MAP3K10.43391734
102PAK10.43099670
103EEF2K0.42147689
104CAMKK20.39984192
105ARAF0.39642618
106AKT30.39108571
107RPS6KA20.38976438
108SGK4940.36537797
109SGK2230.36537797
110PRKD20.35978095
111NTRK30.33955356
112CAMK2G0.33686635
113PLK20.32409735
114MATK0.31680904
115MOS0.31590368
116MAP2K30.30865158
117CAMK2B0.30245660
118TGFBR10.29478754
119KIT0.28467509
120GRK10.27225704
121MARK10.26330971
122PRKAA20.22680281
123MAPKAPK20.22212197
124CLK10.22170891
125AKT20.21304858
126MARK20.20377182
127CDK90.19930976
128CAMK10.19851704

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63770059
2ECM-receptor interaction_Homo sapiens_hsa045122.42947622
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.09192429
4Tryptophan metabolism_Homo sapiens_hsa003801.89589177
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87917343
6Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85466205
7Nitrogen metabolism_Homo sapiens_hsa009101.77609946
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.75088188
9Phenylalanine metabolism_Homo sapiens_hsa003601.68361385
10Fatty acid degradation_Homo sapiens_hsa000711.67048167
11Butanoate metabolism_Homo sapiens_hsa006501.64945022
12Sulfur metabolism_Homo sapiens_hsa009201.64505509
13* Focal adhesion_Homo sapiens_hsa045101.62308451
14Tyrosine metabolism_Homo sapiens_hsa003501.59372715
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56479339
16Protein digestion and absorption_Homo sapiens_hsa049741.54741317
17Chemical carcinogenesis_Homo sapiens_hsa052041.54107635
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49551162
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43822868
20Bile secretion_Homo sapiens_hsa049761.41296657
21PPAR signaling pathway_Homo sapiens_hsa033201.34289899
22Dilated cardiomyopathy_Homo sapiens_hsa054141.32721426
23Arginine biosynthesis_Homo sapiens_hsa002201.32060218
24Complement and coagulation cascades_Homo sapiens_hsa046101.31699227
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31311581
26Fatty acid metabolism_Homo sapiens_hsa012121.30677944
27Histidine metabolism_Homo sapiens_hsa003401.29417769
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.26012833
29Amoebiasis_Homo sapiens_hsa051461.22829675
30Adherens junction_Homo sapiens_hsa045201.22734162
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22016278
32Starch and sucrose metabolism_Homo sapiens_hsa005001.21262343
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21191567
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20292004
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.18559690
36Propanoate metabolism_Homo sapiens_hsa006401.18209894
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13488327
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.13330447
39Proteoglycans in cancer_Homo sapiens_hsa052051.07673699
40Bladder cancer_Homo sapiens_hsa052191.03584723
41Pathways in cancer_Homo sapiens_hsa052001.01526170
42Retinol metabolism_Homo sapiens_hsa008300.98431532
43MicroRNAs in cancer_Homo sapiens_hsa052060.96244463
44Hippo signaling pathway_Homo sapiens_hsa043900.95974686
45Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94532293
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89753619
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88887399
48beta-Alanine metabolism_Homo sapiens_hsa004100.85938944
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85160317
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.83340289
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83001314
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82439719
53Thyroid hormone synthesis_Homo sapiens_hsa049180.81720367
54Tight junction_Homo sapiens_hsa045300.81603372
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80014202
56Peroxisome_Homo sapiens_hsa041460.78898883
57TGF-beta signaling pathway_Homo sapiens_hsa043500.77896660
58N-Glycan biosynthesis_Homo sapiens_hsa005100.77281193
59Wnt signaling pathway_Homo sapiens_hsa043100.76073184
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75798533
61Pyruvate metabolism_Homo sapiens_hsa006200.75108698
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74270294
63Axon guidance_Homo sapiens_hsa043600.74151908
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71864078
65Basal cell carcinoma_Homo sapiens_hsa052170.70451505
66Arginine and proline metabolism_Homo sapiens_hsa003300.70321092
67Caffeine metabolism_Homo sapiens_hsa002320.70039154
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69914448
69Small cell lung cancer_Homo sapiens_hsa052220.68683195
70Insulin secretion_Homo sapiens_hsa049110.68549342
71Hedgehog signaling pathway_Homo sapiens_hsa043400.68203226
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67732327
73Melanoma_Homo sapiens_hsa052180.67362963
74Prostate cancer_Homo sapiens_hsa052150.67260364
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67226142
76Ovarian steroidogenesis_Homo sapiens_hsa049130.65132054
77Cocaine addiction_Homo sapiens_hsa050300.64654547
78Circadian rhythm_Homo sapiens_hsa047100.62678209
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.61560846
80Lysine degradation_Homo sapiens_hsa003100.61508620
81Insulin resistance_Homo sapiens_hsa049310.59892934
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57763640
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.57651452
84Sphingolipid metabolism_Homo sapiens_hsa006000.57622854
85Prion diseases_Homo sapiens_hsa050200.57566351
86Endocytosis_Homo sapiens_hsa041440.57160005
87Glucagon signaling pathway_Homo sapiens_hsa049220.56453996
88Melanogenesis_Homo sapiens_hsa049160.55870127
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55421398
90Malaria_Homo sapiens_hsa051440.54197696
91Chronic myeloid leukemia_Homo sapiens_hsa052200.53870484
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52807331
93Rap1 signaling pathway_Homo sapiens_hsa040150.52269190
94Fat digestion and absorption_Homo sapiens_hsa049750.51232584
95Renin-angiotensin system_Homo sapiens_hsa046140.51019309
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.51002990
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50868864
98ABC transporters_Homo sapiens_hsa020100.50599301
99Gap junction_Homo sapiens_hsa045400.50020065
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49940813
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.49905257
102Estrogen signaling pathway_Homo sapiens_hsa049150.48879178
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48778649
104Ras signaling pathway_Homo sapiens_hsa040140.47640094
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47632226
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47552086
107AMPK signaling pathway_Homo sapiens_hsa041520.47261664
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46821488
109Gastric acid secretion_Homo sapiens_hsa049710.46404982
110Pancreatic secretion_Homo sapiens_hsa049720.46359092
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46233105
112Glutathione metabolism_Homo sapiens_hsa004800.46137654
113Renin secretion_Homo sapiens_hsa049240.45411204
114Galactose metabolism_Homo sapiens_hsa000520.45332355
115Glycerolipid metabolism_Homo sapiens_hsa005610.44970056
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44968178
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44939275
118Thyroid cancer_Homo sapiens_hsa052160.44900314
119Glioma_Homo sapiens_hsa052140.44596910
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.44386197
121Vibrio cholerae infection_Homo sapiens_hsa051100.44271577
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44131211
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43129251
124p53 signaling pathway_Homo sapiens_hsa041150.42774399
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42400283
126Other glycan degradation_Homo sapiens_hsa005110.42097473
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41866355
128cAMP signaling pathway_Homo sapiens_hsa040240.41836499
129Lysosome_Homo sapiens_hsa041420.40653099
130Notch signaling pathway_Homo sapiens_hsa043300.39009085
131Salivary secretion_Homo sapiens_hsa049700.38987012
132Renal cell carcinoma_Homo sapiens_hsa052110.36935823
133Pancreatic cancer_Homo sapiens_hsa052120.36107039
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35589593
135Sulfur relay system_Homo sapiens_hsa041220.35278185

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