PARP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16805006
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16805006
3Golgi transport vesicle coating (GO:0048200)4.09677768
4COPI coating of Golgi vesicle (GO:0048205)4.09677768
5positive regulation of extracellular matrix organization (GO:1903055)3.90543944
6antigen processing and presentation of endogenous antigen (GO:0019883)3.84145881
7regulation of cholesterol homeostasis (GO:2000188)3.84103736
8regulation of extracellular matrix disassembly (GO:0010715)3.82395794
9regulation of cholesterol storage (GO:0010885)3.72542792
10protein retention in ER lumen (GO:0006621)3.72171370
11barbed-end actin filament capping (GO:0051016)3.72108037
12apoptotic cell clearance (GO:0043277)3.67386144
13valine metabolic process (GO:0006573)3.61154813
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56836723
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55550222
16actin filament depolymerization (GO:0030042)3.50725042
17negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.46220068
18low-density lipoprotein particle clearance (GO:0034383)3.41672010
19positive regulation of triglyceride lipase activity (GO:0061365)3.37744067
20positive regulation of lipoprotein lipase activity (GO:0051006)3.37744067
21alpha-linolenic acid metabolic process (GO:0036109)3.37713237
22NADH metabolic process (GO:0006734)3.37053236
23adhesion of symbiont to host cell (GO:0044650)3.35245629
24virion attachment to host cell (GO:0019062)3.35245629
25positive regulation of natural killer cell differentiation (GO:0032825)3.32114976
26extracellular fibril organization (GO:0043206)3.29947120
27positive regulation of triglyceride biosynthetic process (GO:0010867)3.29676471
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.26753104
29adhesion of symbiont to host (GO:0044406)3.25115458
30protein carboxylation (GO:0018214)3.22318325
31peptidyl-glutamic acid carboxylation (GO:0017187)3.22318325
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.20121546
33complement activation, alternative pathway (GO:0006957)3.17545541
34pinocytosis (GO:0006907)3.15933174
35fibril organization (GO:0097435)3.13483539
36negative regulation of fibrinolysis (GO:0051918)3.12305467
37positive regulation of triglyceride metabolic process (GO:0090208)3.10193474
38positive regulation of fatty acid biosynthetic process (GO:0045723)3.09456986
39mannose metabolic process (GO:0006013)3.05539426
40regulation of extracellular matrix organization (GO:1903053)3.03334998
41positive regulation of fatty acid beta-oxidation (GO:0032000)2.97451293
42membrane raft organization (GO:0031579)2.96992064
43negative regulation of lipid storage (GO:0010888)2.93848818
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93071456
45regulation of sequestering of triglyceride (GO:0010889)2.92490836
46positive regulation of fatty acid oxidation (GO:0046321)2.90527532
47regulation of protein activation cascade (GO:2000257)2.89617012
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88857207
49proline biosynthetic process (GO:0006561)2.88132003
50positive regulation of fatty acid metabolic process (GO:0045923)2.86134702
51fatty acid beta-oxidation (GO:0006635)2.85020088
52regulation of complement activation (GO:0030449)2.84372378
53immunoglobulin mediated immune response (GO:0016064)2.83799012
54regulation of metalloenzyme activity (GO:0048552)2.82207091
55regulation of triglyceride biosynthetic process (GO:0010866)2.82118447
56regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.80151842
57positive regulation of sterol transport (GO:0032373)2.80084693
58positive regulation of cholesterol transport (GO:0032376)2.80084693
59fibrinolysis (GO:0042730)2.80032800
60type B pancreatic cell proliferation (GO:0044342)2.78790674
61positive regulation of cholesterol efflux (GO:0010875)2.78704055
62angiotensin maturation (GO:0002003)2.78519019
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.74585579
64L-phenylalanine catabolic process (GO:0006559)2.74503037
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.74503037
66plasma lipoprotein particle clearance (GO:0034381)2.73654618
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.73052725
68L-phenylalanine metabolic process (GO:0006558)2.73052725
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72373883
70regulation of fibrinolysis (GO:0051917)2.71814561
712-oxoglutarate metabolic process (GO:0006103)2.71702909
72sulfur amino acid catabolic process (GO:0000098)2.71040562
73regulation of plasminogen activation (GO:0010755)2.70643621
74hypotonic response (GO:0006971)2.68991912
75triglyceride homeostasis (GO:0070328)2.67785441
76acylglycerol homeostasis (GO:0055090)2.67785441
77negative regulation of B cell apoptotic process (GO:0002903)2.67076697
78protein maturation by protein folding (GO:0022417)2.66749890
79regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66574576
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66227540
81negative regulation of T-helper cell differentiation (GO:0045623)2.66227540
82regulation of cholesterol metabolic process (GO:0090181)2.66179740
83fatty acid transmembrane transport (GO:1902001)2.65195275
84ethanol oxidation (GO:0006069)2.64412855
85positive regulation of receptor recycling (GO:0001921)2.64220305
86peptide catabolic process (GO:0043171)2.63923140
87negative regulation of cytokine production involved in immune response (GO:0002719)2.63908846
88endothelial cell chemotaxis (GO:0035767)2.63832147
89dicarboxylic acid biosynthetic process (GO:0043650)2.63827397
90regulation of triglyceride catabolic process (GO:0010896)2.63294981
91regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.62765440
92protein hydroxylation (GO:0018126)2.61968708
93peptidyl-proline hydroxylation (GO:0019511)2.61962237
94fatty acid oxidation (GO:0019395)2.61782225
95positive regulation of pseudopodium assembly (GO:0031274)2.60766199
96negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.60720437
97protein heterotrimerization (GO:0070208)2.60302881
98response to interferon-alpha (GO:0035455)2.60284373
99regulation of triglyceride metabolic process (GO:0090207)2.60078275
100lysine metabolic process (GO:0006553)2.59728349
101lysine catabolic process (GO:0006554)2.59728349
102endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.59548366
103urea cycle (GO:0000050)2.59190284
104urea metabolic process (GO:0019627)2.59190284
105collagen fibril organization (GO:0030199)2.59173753
106epoxygenase P450 pathway (GO:0019373)2.58366983
107complement activation, classical pathway (GO:0006958)2.58155793
108kynurenine metabolic process (GO:0070189)2.57553209
109lipid oxidation (GO:0034440)2.57106597
110positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56967348
111aromatic amino acid family catabolic process (GO:0009074)2.56899663
112regulation of fatty acid beta-oxidation (GO:0031998)2.56459826
113positive regulation of gamma-delta T cell activation (GO:0046645)2.56266655
114T cell apoptotic process (GO:0070231)2.55820717
115cell adhesion mediated by integrin (GO:0033627)2.54070659
116glyoxylate metabolic process (GO:0046487)2.53104044
117UV protection (GO:0009650)2.51447067
118protein localization to endosome (GO:0036010)2.49423583
119fatty acid catabolic process (GO:0009062)2.49371996
120stress fiber assembly (GO:0043149)2.48904123
121regulation of fatty acid oxidation (GO:0046320)2.48167668
122opsonization (GO:0008228)2.46746466
123basement membrane organization (GO:0071711)2.45413979
124negative regulation of coagulation (GO:0050819)2.44929200
125positive regulation of endothelial cell apoptotic process (GO:2000353)2.44754433
126amino-acid betaine metabolic process (GO:0006577)2.44753295
127regulation of early endosome to late endosome transport (GO:2000641)2.44453963
128positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.44293637
129positive regulation of lipid catabolic process (GO:0050996)2.43986197
130tryptophan catabolic process (GO:0006569)2.43389816
131indole-containing compound catabolic process (GO:0042436)2.43389816
132indolalkylamine catabolic process (GO:0046218)2.43389816
133regulation of pseudopodium assembly (GO:0031272)2.42620623
134GDP-mannose metabolic process (GO:0019673)2.42270317
135cysteine metabolic process (GO:0006534)2.42128601
136regulation of macrophage derived foam cell differentiation (GO:0010743)2.40887770
137negative regulation of protein localization to plasma membrane (GO:1903077)2.40344170
138negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.39829927
139negative regulation of innate immune response (GO:0045824)2.38361506
140proline metabolic process (GO:0006560)2.38275675
141carnitine shuttle (GO:0006853)2.38076069
142cellular glucuronidation (GO:0052695)2.37955375
143skin morphogenesis (GO:0043589)2.37952167
144germinal center formation (GO:0002467)2.37362743
145cellular response to interferon-alpha (GO:0035457)2.37338413
146renal filtration (GO:0097205)2.36755198
147regulation of natural killer cell differentiation (GO:0032823)2.35412577
148nitrogen cycle metabolic process (GO:0071941)2.34810111
149regulation of interleukin-8 biosynthetic process (GO:0045414)2.34646066
150bile acid biosynthetic process (GO:0006699)2.33873339
151carnitine metabolic process (GO:0009437)2.32932021
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32739980
153fructose metabolic process (GO:0006000)2.32515103
154negative regulation of hemostasis (GO:1900047)2.31124666
155negative regulation of blood coagulation (GO:0030195)2.31124666
156regulation of apoptotic cell clearance (GO:2000425)2.30405026
157ethanol metabolic process (GO:0006067)2.30037231
158vascular endothelial growth factor signaling pathway (GO:0038084)2.29639561
159glomerular basement membrane development (GO:0032836)2.29586402
160embryo implantation (GO:0007566)2.28206240
161glutamine family amino acid biosynthetic process (GO:0009084)2.27923826
162negative regulation of cell size (GO:0045792)2.26123601
163cell-substrate junction assembly (GO:0007044)2.24669754
164negative regulation of fatty acid transport (GO:2000192)2.23194784
165complement activation (GO:0006956)2.22014945
166positive regulation of reactive oxygen species metabolic process (GO:2000379)2.21763625
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.20861655
168hyaluronan catabolic process (GO:0030214)2.20760137
169atrioventricular valve morphogenesis (GO:0003181)2.20141725
170regulation of apoptotic process involved in morphogenesis (GO:1902337)2.19838436
171positive regulation of blood vessel endothelial cell migration (GO:0043536)2.17011780

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.40816557
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.27137622
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.21184915
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.85193023
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.53147420
6* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.34376143
7* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33554799
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23534251
9LXR_22158963_ChIP-Seq_LIVER_Mouse3.07129247
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.81001238
11CLOCK_20551151_ChIP-Seq_293T_Human2.80557940
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.73328561
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66284965
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.62807410
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59743193
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.46489122
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29019293
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12910471
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11090262
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10133470
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.09533271
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.03066157
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00286609
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97618060
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96852697
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.96131789
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93618684
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87927260
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87907622
30* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85270477
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83243006
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73295678
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72945247
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70670817
35GATA1_22025678_ChIP-Seq_K562_Human1.62262067
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62201953
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.61462467
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.60635814
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59002379
40ZNF263_19887448_ChIP-Seq_K562_Human1.58608639
41MAF_26560356_Chip-Seq_TH1_Human1.52764811
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52605206
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51489722
44RUNX_20019798_ChIP-Seq_JUKART_Human1.50647365
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.47223062
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45251527
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42619961
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42207689
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41124489
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40943324
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40060661
52* TET1_21451524_ChIP-Seq_MESCs_Mouse1.37790805
53CJUN_26792858_Chip-Seq_BT549_Human1.36890175
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.32989044
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29893687
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28380138
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27830997
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26582940
59VDR_21846776_ChIP-Seq_THP-1_Human1.26217908
60MYC_22102868_ChIP-Seq_BL_Human1.26207129
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26129953
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.25206449
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24421151
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23860681
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23635881
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.23362446
67VDR_24763502_ChIP-Seq_THP-1_Human1.23015750
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20621727
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19673343
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19673343
71MYB_26560356_Chip-Seq_TH2_Human1.19482922
72TP53_22127205_ChIP-Seq_IMR90_Human1.18996292
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18161659
74P68_20966046_ChIP-Seq_HELA_Human1.17623689
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17556146
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17050563
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17010340
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.15842068
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.15234965
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.15234965
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12231037
82LXR_22292898_ChIP-Seq_THP-1_Human1.11641110
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11030956
84BCOR_27268052_Chip-Seq_Bcells_Human1.11027963
85* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10594877
86MYB_26560356_Chip-Seq_TH1_Human1.10022300
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09421899
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09064484
89SMC4_20622854_ChIP-Seq_HELA_Human1.08933288
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08417551
91KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07780748
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.07509908
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06245630
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06116602
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06116602
96FOXO3_23340844_ChIP-Seq_DLD1_Human1.04914535
97GATA1_19941827_ChIP-Seq_MEL_Mouse1.04622326
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04324759
99* BCL6_27268052_Chip-Seq_Bcells_Human1.04240653
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04098041
101UTX_26944678_Chip-Seq_JUKART_Human1.03915045
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03620991
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03284406
104EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02701421
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02546520
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01959016
107* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01341933
108* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01287502
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01167356
110ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00862618
111SOX2_20726797_ChIP-Seq_SW620_Human1.00643909
112UBF1/2_26484160_Chip-Seq_HMECs_Human1.00525738
113SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00141469
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99844197
115VDR_24787735_ChIP-Seq_THP-1_Human0.99751350
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.99175683
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98310614
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97906918
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.97717929
120* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.96934517
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96575756
122RACK7_27058665_Chip-Seq_MCF-7_Human0.96276089
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96043180
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95226314
125KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94997738
126SPI1_23127762_ChIP-Seq_K562_Human0.93786729
127PU_27001747_Chip-Seq_BMDM_Mouse0.93543864
128* TCF7_22412390_ChIP-Seq_EML_Mouse0.93388639
129CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92442602
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92001342
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91768263
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.91722654
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91344069
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91323175
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91310896
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.91229880
137ATF3_27146783_Chip-Seq_COLON_Human0.89737642
138KDM2B_26808549_Chip-Seq_DND41_Human0.87265697
139KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86413142
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85358961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.82133842
2MP0002139_abnormal_hepatobiliary_system4.66909973
3MP0003191_abnormal_cellular_cholesterol3.11914820
4MP0005275_abnormal_skin_tensile2.88383481
5MP0003705_abnormal_hypodermis_morpholog2.82329061
6MP0005451_abnormal_body_composition2.80642023
7MP0005365_abnormal_bile_salt2.53323471
8MP0005360_urolithiasis2.51113610
9MP0003279_aneurysm2.32102425
10MP0000685_abnormal_immune_system2.23372334
11MP0005503_abnormal_tendon_morphology2.22790224
12MP0005257_abnormal_intraocular_pressure2.11849270
13MP0001958_emphysema2.01479815
14MP0003724_increased_susceptibility_to1.86471108
15MP0003183_abnormal_peptide_metabolism1.85113212
16MP0001835_abnormal_antigen_presentation1.80179219
17MP0002877_abnormal_melanocyte_morpholog1.79308010
18MP0003806_abnormal_nucleotide_metabolis1.77106078
19MP0009840_abnormal_foam_cell1.75325358
20MP0003436_decreased_susceptibility_to1.74524169
21MP0005085_abnormal_gallbladder_physiolo1.73704805
22MP0003950_abnormal_plasma_membrane1.70658260
23MP0010329_abnormal_lipoprotein_level1.64627141
24MP0003252_abnormal_bile_duct1.64415228
25MP0008260_abnormal_autophagy1.64216723
26MP0009384_cardiac_valve_regurgitation1.63258938
27MP0004130_abnormal_muscle_cell1.61661710
28MP0002166_altered_tumor_susceptibility1.56800325
29MP0005670_abnormal_white_adipose1.56358136
30MP0004858_abnormal_nervous_system1.52356951
31MP0005387_immune_system_phenotype1.48235450
32MP0001790_abnormal_immune_system1.48235450
33MP0000013_abnormal_adipose_tissue1.43938317
34MP0005023_abnormal_wound_healing1.43781404
35MP0003172_abnormal_lysosome_physiology1.43390929
36MP0000749_muscle_degeneration1.42567287
37MP0002837_dystrophic_cardiac_calcinosis1.42069121
38MP0002933_joint_inflammation1.41513940
39MP0009785_altered_susceptibility_to1.40785335
40MP0009780_abnormal_chondrocyte_physiolo1.40542006
41MP0001853_heart_inflammation1.40362726
42MP0003566_abnormal_cell_adhesion1.39936105
43MP0005058_abnormal_lysosome_morphology1.39461377
44MP0003300_gastrointestinal_ulcer1.38800788
45MP0003075_altered_response_to1.35648224
46MP0001533_abnormal_skeleton_physiology1.35343271
47MP0008875_abnormal_xenobiotic_pharmacok1.34566423
48MP0005165_increased_susceptibility_to1.34191077
49MP0000751_myopathy1.33814745
50MP0002060_abnormal_skin_morphology1.33366462
51MP0000609_abnormal_liver_physiology1.27391052
52MP0001849_ear_inflammation1.26697313
53MP0000003_abnormal_adipose_tissue1.23324749
54MP0005666_abnormal_adipose_tissue1.22833512
55MP0000343_altered_response_to1.20932629
56MP0005319_abnormal_enzyme/_coenzyme1.19039615
57MP0000858_altered_metastatic_potential1.18695041
58MP0001666_abnormal_nutrient_absorption1.18638000
59MP0005025_abnormal_response_to1.15501820
60MP0008469_abnormal_protein_level1.15207232
61MP0002419_abnormal_innate_immunity1.13689809
62MP0005083_abnormal_biliary_tract1.12812689
63MP0001243_abnormal_dermal_layer1.12072201
64MP0001800_abnormal_humoral_immune1.11994719
65MP0006082_CNS_inflammation1.11849616
66MP0004185_abnormal_adipocyte_glucose1.10845370
67MP0005166_decreased_susceptibility_to1.10821647
68MP0003091_abnormal_cell_migration1.09747143
69MP0005000_abnormal_immune_tolerance1.07636315
70MP0004087_abnormal_muscle_fiber1.07472159
71MP0010368_abnormal_lymphatic_system1.07321502
72MP0005332_abnormal_amino_acid1.07175111
73MP0003303_peritoneal_inflammation1.06494347
74MP0005623_abnormal_meninges_morphology1.05931060
75MP0000604_amyloidosis1.05643412
76MP0002006_tumorigenesis1.04302627
77MP0002452_abnormal_antigen_presenting1.02742416
78MP0002118_abnormal_lipid_homeostasis1.02496081
79MP0000750_abnormal_muscle_regeneration1.01992276
80MP0005671_abnormal_response_to1.01886485
81MP0004272_abnormal_basement_membrane1.01463106
82MP0002148_abnormal_hypersensitivity_rea1.01373958
83MP0005164_abnormal_response_to1.01300097
84MP0009643_abnormal_urine_homeostasis0.99547741
85MP0002254_reproductive_system_inflammat0.98818792
86MP0009764_decreased_sensitivity_to0.97713307
87MP0002971_abnormal_brown_adipose0.96931606
88MP0005464_abnormal_platelet_physiology0.96246948
89MP0002132_abnormal_respiratory_system0.96050947
90MP0004947_skin_inflammation0.94944599
91MP0000733_abnormal_muscle_development0.94925830
92MP0002723_abnormal_immune_serum0.94249760
93MP0002295_abnormal_pulmonary_circulatio0.94131033
94MP0002896_abnormal_bone_mineralization0.93959297
95MP0000767_abnormal_smooth_muscle0.93243654
96MP0000249_abnormal_blood_vessel0.92906251
97MP0002998_abnormal_bone_remodeling0.92550587
98MP0005390_skeleton_phenotype0.91997376
99MP0000678_abnormal_parathyroid_gland0.91671390
100MP0003646_muscle_fatigue0.91140430
101MP0001845_abnormal_inflammatory_respons0.90651160
102MP0005409_darkened_coat_color0.89701222
103MP0000747_muscle_weakness0.89554501
104MP0005375_adipose_tissue_phenotype0.89177529
105MP0009763_increased_sensitivity_to0.88692245
106MP0004510_myositis0.88235319
107MP0005408_hypopigmentation0.87632670
108MP0001661_extended_life_span0.87053062
109MP0006054_spinal_hemorrhage0.86963022
110MP0000759_abnormal_skeletal_muscle0.86287582
111MP0002108_abnormal_muscle_morphology0.86158924
112MP0005508_abnormal_skeleton_morphology0.84720510
113MP0003186_abnormal_redox_activity0.83505330
114MP0005330_cardiomyopathy0.83159453
115MP0001542_abnormal_bone_strength0.82951764
116MP0001819_abnormal_immune_cell0.81856056
117MP0002405_respiratory_system_inflammati0.81850802
118MP0002420_abnormal_adaptive_immunity0.81811700
119MP0010352_gastrointestinal_tract_polyps0.81043970
120MP0002138_abnormal_hepatobiliary_system0.80364659
121MP0003045_fibrosis0.78987139
122MP0005584_abnormal_enzyme/coenzyme_acti0.78542770
123MP0000598_abnormal_liver_morphology0.78513014
124MP0002396_abnormal_hematopoietic_system0.77762321
125MP0010155_abnormal_intestine_physiology0.77441207
126MP0009115_abnormal_fat_cell0.77144131
127MP0010630_abnormal_cardiac_muscle0.76320594
128MP0002168_other_aberrant_phenotype0.76281230
129MP0000681_abnormal_thyroid_gland0.75713907
130MP0009278_abnormal_bone_marrow0.71154178
131MP0004264_abnormal_extraembryonic_tissu0.70892449
132MP0003868_abnormal_feces_composition0.70715976
133MP0009333_abnormal_splenocyte_physiolog0.70441872

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.85402825
2Premature rupture of membranes (HP:0001788)4.42198762
3Type 1 muscle fiber predominance (HP:0003803)3.66824707
4Increased connective tissue (HP:0009025)3.59897954
5Peritonitis (HP:0002586)3.40806267
6Aortic dissection (HP:0002647)3.21624444
7Deep venous thrombosis (HP:0002625)3.07315211
8Myocardial infarction (HP:0001658)3.02083249
9Xanthomatosis (HP:0000991)3.01985466
10Complement deficiency (HP:0004431)3.00009849
11Aortic aneurysm (HP:0004942)2.98591895
12Broad metatarsal (HP:0001783)2.82290740
13Distal lower limb muscle weakness (HP:0009053)2.81768578
14Vertebral compression fractures (HP:0002953)2.80931235
15Muscle fiber inclusion bodies (HP:0100299)2.74424567
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.73322222
17Dysostosis multiplex (HP:0000943)2.72834662
18Vascular tortuosity (HP:0004948)2.72833558
19Abnormality of complement system (HP:0005339)2.70984797
20Ankle contracture (HP:0006466)2.66709430
21Cerebral aneurysm (HP:0004944)2.56720811
22Osteolytic defects of the hand bones (HP:0009699)2.56401642
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.56401642
24Round ear (HP:0100830)2.52067311
25Arterial tortuosity (HP:0005116)2.51545508
26Mildly elevated creatine phosphokinase (HP:0008180)2.48813331
27Hypoalphalipoproteinemia (HP:0003233)2.45190295
28Joint stiffness (HP:0001387)2.42979981
29Systemic lupus erythematosus (HP:0002725)2.41040861
30Glucose intolerance (HP:0000833)2.39982391
31Hemorrhage of the eye (HP:0011885)2.38535478
32Dilatation of the ascending aorta (HP:0005111)2.37924031
33Cervical subluxation (HP:0003308)2.37513390
34Nemaline bodies (HP:0003798)2.36870025
35Urinary glycosaminoglycan excretion (HP:0003541)2.34429199
36Mucopolysacchariduria (HP:0008155)2.34429199
37Mitral stenosis (HP:0001718)2.33429655
38Hyperlipoproteinemia (HP:0010980)2.28490667
39Abnormality of the common coagulation pathway (HP:0010990)2.28413921
40Ectopia lentis (HP:0001083)2.27303836
41Biconcave vertebral bodies (HP:0004586)2.26859645
42Spinal rigidity (HP:0003306)2.25584686
43Abnormality of fatty-acid metabolism (HP:0004359)2.24856317
44Muscle fiber splitting (HP:0003555)2.24480161
45Bladder diverticulum (HP:0000015)2.24306539
46Exercise-induced muscle cramps (HP:0003710)2.23123902
47Hyporeflexia of lower limbs (HP:0002600)2.22088138
48Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20745650
49Autoimmune thrombocytopenia (HP:0001973)2.19983904
50Purpura (HP:0000979)2.17938246
51Abnormality of the peritoneum (HP:0002585)2.17245125
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15787568
53Abnormality of polysaccharide metabolism (HP:0011012)2.15787568
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15787568
55Spondylolisthesis (HP:0003302)2.14934604
56Abnormality of skeletal muscle fiber size (HP:0012084)2.14297090
57Ulnar deviation of the wrist (HP:0003049)2.14139681
58Amyloidosis (HP:0011034)2.13445999
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12794804
60Upper limb amyotrophy (HP:0009129)2.12284614
61Distal upper limb amyotrophy (HP:0007149)2.12284614
62Soft skin (HP:0000977)2.12133049
63Blue sclerae (HP:0000592)2.12113402
64Absent phalangeal crease (HP:0006109)2.11220105
65Intrahepatic cholestasis (HP:0001406)2.11115419
66Slender build (HP:0001533)2.11046454
67Myoglobinuria (HP:0002913)2.10036984
68Distal arthrogryposis (HP:0005684)2.08777227
69Recurrent gram-negative bacterial infections (HP:0005420)2.07078050
70Atrophic scars (HP:0001075)2.05790231
71Shallow orbits (HP:0000586)2.04395340
72Elevated erythrocyte sedimentation rate (HP:0003565)2.04227187
73Eczematoid dermatitis (HP:0000976)2.04028623
74Exercise-induced myalgia (HP:0003738)2.03868077
75Hyperacusis (HP:0010780)2.03497204
76Increased variability in muscle fiber diameter (HP:0003557)2.02975293
77Mitral valve prolapse (HP:0001634)2.02947394
78Right ventricular cardiomyopathy (HP:0011663)2.02875095
79Abnormality of the Achilles tendon (HP:0005109)2.02756401
80Vascular calcification (HP:0004934)2.01944233
81Abnormal delivery (HP:0001787)2.01924796
82Abnormal cartilage morphology (HP:0002763)2.01312420
83Nephritis (HP:0000123)2.01221610
84Abnormality of proline metabolism (HP:0010907)2.01018181
85Hydroxyprolinuria (HP:0003080)2.01018181
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00696215
87Follicular hyperkeratosis (HP:0007502)2.00290539
88Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99921411
89Difficulty running (HP:0009046)1.98980135
90Thin bony cortex (HP:0002753)1.98824027
91Cholecystitis (HP:0001082)1.98780744
92Abnormal gallbladder physiology (HP:0012438)1.98780744
93Short nail (HP:0001799)1.97715063
94Achilles tendon contracture (HP:0001771)1.95335374
95Elbow flexion contracture (HP:0002987)1.95225483
96Asymmetric septal hypertrophy (HP:0001670)1.93931881
97Rhabdomyolysis (HP:0003201)1.93198210
98Gastrointestinal stroma tumor (HP:0100723)1.92820807
99Fragile skin (HP:0001030)1.92256435
100Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.92032535
101Hypolipoproteinemia (HP:0010981)1.91707227
102Abnormality of carpal bone ossification (HP:0006257)1.89306118
103Aneurysm (HP:0002617)1.89285173
104Abnormal glucose tolerance (HP:0001952)1.88695888
105Beaking of vertebral bodies (HP:0004568)1.88290264
106Abnormality of the acetabulum (HP:0003170)1.88218893
107Abnormality of dentin (HP:0010299)1.88073823
108Emphysema (HP:0002097)1.87974760
109Wormian bones (HP:0002645)1.87915701
110Abnormality of the nasal mucosa (HP:0000433)1.87662334
111Difficulty climbing stairs (HP:0003551)1.85799387
112Hyperammonemia (HP:0001987)1.85105797
113Glomerulonephritis (HP:0000099)1.84715769
114Growth hormone excess (HP:0000845)1.84446363
115Centrally nucleated skeletal muscle fibers (HP:0003687)1.83927461
116Coxa vara (HP:0002812)1.83194342
117Reduced subcutaneous adipose tissue (HP:0003758)1.82480713
118Prolonged partial thromboplastin time (HP:0003645)1.82327732
119Myopathic facies (HP:0002058)1.81949147
120Cardiovascular calcification (HP:0011915)1.81904599
121Increased mean platelet volume (HP:0011877)1.81442203
122Hypertriglyceridemia (HP:0002155)1.81090182
123Interstitial pulmonary disease (HP:0006530)1.79811229
124Acanthosis nigricans (HP:0000956)1.79581065
125Facial diplegia (HP:0001349)1.79174585
126Abnormality of the distal phalanges of the toes (HP:0010182)1.79140624
127Hyperglycinuria (HP:0003108)1.79090595
128Abnormality of the intrinsic pathway (HP:0010989)1.78622938
129Epidermoid cyst (HP:0200040)1.78074389
130Colitis (HP:0002583)1.76958207
131Ketosis (HP:0001946)1.76949563
132Malnutrition (HP:0004395)1.76339238
133Lipoatrophy (HP:0100578)1.76130799
134Joint hemorrhage (HP:0005261)1.75975013
135Generalized amyotrophy (HP:0003700)1.75707024
136Camptodactyly of toe (HP:0001836)1.75527763
137Alopecia of scalp (HP:0002293)1.75234834
138EMG: myopathic abnormalities (HP:0003458)1.75027814
139Skin nodule (HP:0200036)1.74869427
140Distal lower limb amyotrophy (HP:0008944)1.74633415
141Chronic otitis media (HP:0000389)1.74454354
142Ovoid vertebral bodies (HP:0003300)1.74417325
143Abnormality of iron homeostasis (HP:0011031)1.74285221
144Aortic regurgitation (HP:0001659)1.73286180
145Mitral regurgitation (HP:0001653)1.71007712
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.70263812
147Abnormality of glycolipid metabolism (HP:0010969)1.70263812
148Abnormality of liposaccharide metabolism (HP:0010968)1.70263812
149Fatigue (HP:0012378)1.70194929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.70673476
2TRIB33.67087738
3ERN13.55458033
4PRPF4B3.10443354
5TESK12.81083645
6PKN22.60002140
7FGFR42.47001746
8TYK22.42783523
9MAP4K12.30139280
10EPHA22.25751743
11SIK12.23187608
12MAP2K32.18880706
13TBK12.07907233
14MUSK2.06710554
15ICK2.01498371
16KIT1.99848904
17BCKDK1.98480310
18JAK31.91113030
19SMG11.91107419
20JAK11.83263618
21NEK91.82211186
22MAP3K141.74976479
23LIMK11.74021591
24FLT31.68470713
25IKBKB1.62035882
26SCYL21.55994690
27PIK3CG1.55978698
28TGFBR21.49403472
29PTK61.49078880
30LRRK21.47642753
31IKBKE1.47113604
32TESK21.43559016
33PDGFRA1.42779265
34PIK3CA1.42484620
35MAP3K121.40800270
36TRPM71.37563325
37EPHB11.36377434
38PIM21.35680847
39ZAP701.34531414
40EPHA31.34284807
41MAP3K61.31805875
42MST1R1.31424047
43OBSCN1.30248733
44NME21.29113149
45ARAF1.24895961
46RIPK11.24341485
47DDR21.22915575
48PRKD21.22446901
49PAK41.22442054
50MYLK1.21563764
51FGFR31.21256824
52MAP3K71.14388140
53CAMK1D1.11406412
54CSF1R1.09331528
55STK101.07365637
56RIPK41.05691928
57CDC42BPA1.03944493
58MAP3K31.02880399
59PRKD31.00039899
60CSK0.95786145
61KDR0.95707351
62DMPK0.93600729
63MAP3K10.90093722
64EEF2K0.89262215
65BLK0.86313440
66BMX0.84306189
67IRAK30.83804194
68RPS6KA40.83220363
69JAK20.81180688
70MAP3K100.81126244
71TAOK30.80810160
72PAK20.80476184
73PDPK10.79447500
74HCK0.77135939
75ITK0.76734859
76IRAK40.75806122
77DAPK10.74563813
78NLK0.73993689
79MAPK110.73691820
80TXK0.71105739
81MOS0.70779096
82MAPK120.69919570
83HIPK20.69007919
84MAP3K130.68432029
85NTRK10.68419477
86PRKAA20.68266801
87TEC0.67897396
88FRK0.67433319
89BTK0.66175382
90MAPK70.65059075
91RPS6KA20.64795212
92GRK60.63415627
93LCK0.62506443
94ILK0.61778495
95STK380.60843328
96ROCK10.60337803
97CHUK0.59898385
98MAP3K20.58358561
99PDGFRB0.58101946
100ABL20.57523152
101BMPR20.55438224
102PHKG10.54793238
103PHKG20.54793238
104PDK20.54690880
105PRKG20.52764164
106PDK40.50226963
107PDK30.50226963
108CDK60.49791960
109PTK20.49103244
110SYK0.48306624
111PRKCH0.48051446
112DAPK30.47897068
113CAMK1G0.47396688
114PIM10.47113968
115MAPK40.46718547
116MET0.46331039
117MAP3K110.45587239
118PRKD10.45557520
119PTK2B0.45430015
120MAP2K10.45302881
121MAPKAPK20.44024927
122ABL10.43503999
123TAOK20.43131028
124PDK10.41225254
125IGF1R0.41210860
126SIK30.41128583
127TAOK10.39647023
128LMTK20.39427654
129CAMK2G0.39400733
130MTOR0.38824300
131LATS10.38460508
132MAP3K80.37977203
133MAPKAPK30.37916197
134RET0.37160509
135GRK50.37138674
136MAP2K20.36498797
137LATS20.35882741
138EIF2AK10.35835351
139MARK20.34318247
140AKT30.33846622

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.13057908
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.63352754
3Fatty acid degradation_Homo sapiens_hsa000712.57857522
4PPAR signaling pathway_Homo sapiens_hsa033202.40311290
5Staphylococcus aureus infection_Homo sapiens_hsa051502.35185059
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30407144
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28169064
8Complement and coagulation cascades_Homo sapiens_hsa046102.27924892
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21072812
10Nitrogen metabolism_Homo sapiens_hsa009102.12650806
11Fructose and mannose metabolism_Homo sapiens_hsa000512.11164658
12Propanoate metabolism_Homo sapiens_hsa006402.06885188
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96719280
14Caffeine metabolism_Homo sapiens_hsa002321.95159489
15Tryptophan metabolism_Homo sapiens_hsa003801.87442668
16Fatty acid metabolism_Homo sapiens_hsa012121.86870594
17Arginine biosynthesis_Homo sapiens_hsa002201.84668020
18Galactose metabolism_Homo sapiens_hsa000521.73690458
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59462120
20Peroxisome_Homo sapiens_hsa041461.56248173
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52998977
22Malaria_Homo sapiens_hsa051441.45647886
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44565389
24Starch and sucrose metabolism_Homo sapiens_hsa005001.41997122
25Renin-angiotensin system_Homo sapiens_hsa046141.34867852
26beta-Alanine metabolism_Homo sapiens_hsa004101.34423343
27Leishmaniasis_Homo sapiens_hsa051401.30225415
28Chemical carcinogenesis_Homo sapiens_hsa052041.27703346
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26490900
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.21872263
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20570393
32Glutathione metabolism_Homo sapiens_hsa004801.20567935
33ECM-receptor interaction_Homo sapiens_hsa045121.19380483
34Carbon metabolism_Homo sapiens_hsa012001.14579326
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.14574564
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08165640
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08052284
38Allograft rejection_Homo sapiens_hsa053301.06010898
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.05391607
40Viral myocarditis_Homo sapiens_hsa054161.05126799
41Autoimmune thyroid disease_Homo sapiens_hsa053201.02623499
42Prion diseases_Homo sapiens_hsa050201.02489085
43Glycosaminoglycan degradation_Homo sapiens_hsa005310.98694474
44Osteoclast differentiation_Homo sapiens_hsa043800.96624820
45Focal adhesion_Homo sapiens_hsa045100.95939044
46Insulin resistance_Homo sapiens_hsa049310.95905545
47B cell receptor signaling pathway_Homo sapiens_hsa046620.94810076
48Histidine metabolism_Homo sapiens_hsa003400.94636459
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.94619197
50Fatty acid biosynthesis_Homo sapiens_hsa000610.93875018
51Primary immunodeficiency_Homo sapiens_hsa053400.93610603
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93367167
53Pyruvate metabolism_Homo sapiens_hsa006200.93298428
54Asthma_Homo sapiens_hsa053100.93258197
55Phenylalanine metabolism_Homo sapiens_hsa003600.92986933
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91688855
57Protein digestion and absorption_Homo sapiens_hsa049740.91540153
58Toxoplasmosis_Homo sapiens_hsa051450.91060931
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89477060
60ABC transporters_Homo sapiens_hsa020100.89425271
61Butanoate metabolism_Homo sapiens_hsa006500.88305585
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86822369
63Graft-versus-host disease_Homo sapiens_hsa053320.85703567
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.85693131
65Amoebiasis_Homo sapiens_hsa051460.85149450
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.82710310
67Pertussis_Homo sapiens_hsa051330.82477813
68Measles_Homo sapiens_hsa051620.79310391
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77778148
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77491430
71TNF signaling pathway_Homo sapiens_hsa046680.77343380
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.75436385
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75211090
74Sulfur relay system_Homo sapiens_hsa041220.75023468
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73818277
76Tyrosine metabolism_Homo sapiens_hsa003500.73079036
77Bile secretion_Homo sapiens_hsa049760.72495155
78Lysine degradation_Homo sapiens_hsa003100.71324994
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70459119
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69660932
81Retinol metabolism_Homo sapiens_hsa008300.69470868
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.69187332
83Tuberculosis_Homo sapiens_hsa051520.69073321
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68705059
85Sulfur metabolism_Homo sapiens_hsa009200.68534854
86Pancreatic cancer_Homo sapiens_hsa052120.66280739
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66103167
88Other glycan degradation_Homo sapiens_hsa005110.66001924
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65779645
90Influenza A_Homo sapiens_hsa051640.64234028
91Biosynthesis of amino acids_Homo sapiens_hsa012300.63956692
92Platelet activation_Homo sapiens_hsa046110.63929800
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63505479
94Pentose phosphate pathway_Homo sapiens_hsa000300.63358894
95Proteoglycans in cancer_Homo sapiens_hsa052050.63042924
96Lysosome_Homo sapiens_hsa041420.62193404
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61430818
98Glycerolipid metabolism_Homo sapiens_hsa005610.61026631
99Legionellosis_Homo sapiens_hsa051340.60988743
100Selenocompound metabolism_Homo sapiens_hsa004500.60966680
101Shigellosis_Homo sapiens_hsa051310.59548989
102Mineral absorption_Homo sapiens_hsa049780.59455042
103Dilated cardiomyopathy_Homo sapiens_hsa054140.58780646
104Bladder cancer_Homo sapiens_hsa052190.58750430
105Antigen processing and presentation_Homo sapiens_hsa046120.58630144
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57310861
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.56363154
108Acute myeloid leukemia_Homo sapiens_hsa052210.55882952
109Arginine and proline metabolism_Homo sapiens_hsa003300.55749224
110Hepatitis C_Homo sapiens_hsa051600.55607504
111* Apoptosis_Homo sapiens_hsa042100.54928611
112N-Glycan biosynthesis_Homo sapiens_hsa005100.54916303
113Small cell lung cancer_Homo sapiens_hsa052220.54652595
114Endocytosis_Homo sapiens_hsa041440.54572830
115Fatty acid elongation_Homo sapiens_hsa000620.54562292
116Sphingolipid metabolism_Homo sapiens_hsa006000.53413443
117Insulin signaling pathway_Homo sapiens_hsa049100.53404042
118Fat digestion and absorption_Homo sapiens_hsa049750.52662402
119Herpes simplex infection_Homo sapiens_hsa051680.52214986
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51480994
121Arachidonic acid metabolism_Homo sapiens_hsa005900.51414847
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50909347
123Phagosome_Homo sapiens_hsa041450.50726420
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50120079
125Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49492485
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49115207
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47187402
128Chronic myeloid leukemia_Homo sapiens_hsa052200.47156642
129Vibrio cholerae infection_Homo sapiens_hsa051100.46402963
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46015975
131Notch signaling pathway_Homo sapiens_hsa043300.39272159

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