PARP14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.37675797
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.37675797
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.37675797
4modulation by symbiont of host immune response (GO:0052553)6.37675797
5positive regulation by symbiont of host defense response (GO:0052509)6.37675797
6modulation by symbiont of host defense response (GO:0052031)6.37675797
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.76948495
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.76948495
9positive regulation of interferon-alpha production (GO:0032727)5.65370405
10response to type I interferon (GO:0034340)5.45584555
11cellular response to type I interferon (GO:0071357)5.45054269
12type I interferon signaling pathway (GO:0060337)5.45054269
13regulation of interferon-alpha production (GO:0032647)5.36011191
14positive regulation of gamma-delta T cell activation (GO:0046645)5.34045303
15antigen processing and presentation of endogenous antigen (GO:0019883)5.30187708
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21981636
17response to interferon-alpha (GO:0035455)4.82126613
18response to peptidoglycan (GO:0032494)4.65098733
19response to host immune response (GO:0052572)4.63361458
20response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.63361458
21macrophage activation involved in immune response (GO:0002281)4.53647745
22regulation of interferon-beta biosynthetic process (GO:0045357)4.50257100
23response to host (GO:0075136)4.20139723
24response to host defenses (GO:0052200)4.20139723
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.20139723
26NIK/NF-kappaB signaling (GO:0038061)4.19499984
27positive regulation of interferon-beta production (GO:0032728)4.14016298
28regulation of interleukin-12 biosynthetic process (GO:0045075)4.04075342
29interferon-gamma-mediated signaling pathway (GO:0060333)4.02722088
30response to muramyl dipeptide (GO:0032495)4.01067657
31detection of external biotic stimulus (GO:0098581)3.86262509
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85943843
33neutrophil activation involved in immune response (GO:0002283)3.82946198
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.82331734
35positive regulation of cellular amide metabolic process (GO:0034250)3.80812103
36cellular response to virus (GO:0098586)3.80767451
37regulation of gamma-delta T cell activation (GO:0046643)3.78738995
38I-kappaB phosphorylation (GO:0007252)3.78274431
39negative regulation of viral genome replication (GO:0045071)3.78164844
40positive regulation of antigen processing and presentation (GO:0002579)3.77536290
41regulation of RIG-I signaling pathway (GO:0039535)3.77352536
42detection of bacterium (GO:0016045)3.75666673
43regulation of dendritic cell antigen processing and presentation (GO:0002604)3.73854593
44immunoglobulin mediated immune response (GO:0016064)3.72723979
45negative regulation of T cell mediated immunity (GO:0002710)3.66628794
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64320842
47positive regulation of natural killer cell differentiation (GO:0032825)3.61991648
48natural killer cell mediated cytotoxicity (GO:0042267)3.59265141
49natural killer cell mediated immunity (GO:0002228)3.59265141
50microglial cell activation (GO:0001774)3.57872392
51cellular response to interferon-beta (GO:0035458)3.55876021
52lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55297411
53positive regulation of humoral immune response (GO:0002922)3.51633419
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.48906726
55regulation of type I interferon-mediated signaling pathway (GO:0060338)3.47958956
56cellular response to interferon-alpha (GO:0035457)3.44262858
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.44126452
58positive regulation of T cell cytokine production (GO:0002726)3.40750108
59positive regulation of interleukin-12 production (GO:0032735)3.37891078
60positive regulation of type 2 immune response (GO:0002830)3.36021881
61detection of biotic stimulus (GO:0009595)3.35755601
62T cell migration (GO:0072678)3.34577076
63regulation of T-helper 1 cell differentiation (GO:0045625)3.33838090
64positive regulation of toll-like receptor signaling pathway (GO:0034123)3.32086289
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.27670469
66B cell receptor signaling pathway (GO:0050853)3.26132635
67positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.23602680
68cellular extravasation (GO:0045123)3.22606919
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.22158249
70defense response to virus (GO:0051607)3.19857138
71regulation of antigen processing and presentation (GO:0002577)3.17713555
72detection of molecule of bacterial origin (GO:0032490)3.16604477
73cellular response to interferon-gamma (GO:0071346)3.16334265
74germinal center formation (GO:0002467)3.16156360
75negative regulation of interleukin-12 production (GO:0032695)3.15828038
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.15529126
77negative thymic T cell selection (GO:0045060)3.15177393
78regulation of T cell tolerance induction (GO:0002664)3.14808916
79regulation of gamma-delta T cell differentiation (GO:0045586)3.12473772
80regulation of interferon-beta production (GO:0032648)3.09157355
81regulation of tolerance induction (GO:0002643)3.07384526
82negative T cell selection (GO:0043383)3.07304483
83response to protozoan (GO:0001562)3.06766942
84myeloid cell activation involved in immune response (GO:0002275)3.06618468
85granulocyte activation (GO:0036230)3.06124879
86regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.05507471
87regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05326635
88response to interferon-beta (GO:0035456)3.03747670
89positive regulation of response to biotic stimulus (GO:0002833)3.02339024
90positive regulation of chemokine biosynthetic process (GO:0045080)3.01203291
91positive thymic T cell selection (GO:0045059)2.99940264
92T-helper 1 type immune response (GO:0042088)2.99754011
93macrophage activation (GO:0042116)2.98896304
94cellular response to exogenous dsRNA (GO:0071360)2.98486990
95defense response to protozoan (GO:0042832)2.95927507
96response to interleukin-15 (GO:0070672)2.95733723
97neutrophil activation (GO:0042119)2.94812642
98regulation of interleukin-12 production (GO:0032655)2.93975977
99respiratory burst (GO:0045730)2.93694619
100production of molecular mediator involved in inflammatory response (GO:0002532)2.93129023
101negative regulation of leukocyte mediated immunity (GO:0002704)2.90110685
102positive regulation of interleukin-17 production (GO:0032740)2.89804658
103cellular response to ethanol (GO:0071361)2.89046223
104positive regulation of B cell differentiation (GO:0045579)2.88394441
105regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87817509
106regulation of regulatory T cell differentiation (GO:0045589)2.84778177
107negative regulation of myeloid cell apoptotic process (GO:0033033)2.84412338
108interferon-gamma production (GO:0032609)2.84223214
109regulation of necroptotic process (GO:0060544)2.83068272
110regulation of alpha-beta T cell proliferation (GO:0046640)2.81738410
111leukocyte aggregation (GO:0070486)2.81654102
112antigen processing and presentation via MHC class Ib (GO:0002475)2.81028095
113interferon-gamma secretion (GO:0072643)2.79952368
114regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.78347284
115detection of other organism (GO:0098543)2.78294379
116regulation of T cell mediated cytotoxicity (GO:0001914)2.78281939
117regulation of type 2 immune response (GO:0002828)2.77949400
118hydrogen peroxide biosynthetic process (GO:0050665)2.76982014
119regulation of interleukin-17 production (GO:0032660)2.76617890
120negative regulation of cytokine production involved in immune response (GO:0002719)2.76521217
121mature B cell differentiation (GO:0002335)2.75755406
122B cell mediated immunity (GO:0019724)2.75213385
123regulation of B cell receptor signaling pathway (GO:0050855)2.74606282
124regulation of toll-like receptor signaling pathway (GO:0034121)2.73965486
125response to interferon-gamma (GO:0034341)2.71284548
126regulation of response to interferon-gamma (GO:0060330)2.70477507
127positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70230357
128regulation of cholesterol storage (GO:0010885)2.68336386
129myeloid dendritic cell differentiation (GO:0043011)2.67535236
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67057678
131negative regulation of cell killing (GO:0031342)2.67057678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.98643664
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.12250554
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.89237186
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.65337024
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.50331156
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.05963420
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.64221956
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.57273224
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51254190
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37640102
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.00325697
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90064097
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82581053
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81869255
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70746314
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64061145
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59387296
18GATA1_22025678_ChIP-Seq_K562_Human2.58161893
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.41847854
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33034382
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12783043
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05485158
23RUNX_20019798_ChIP-Seq_JUKART_Human1.84376465
24MAF_26560356_Chip-Seq_TH1_Human1.84149742
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83068261
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79040920
27MYB_26560356_Chip-Seq_TH2_Human1.78361003
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71227437
29SCL_19346495_ChIP-Seq_HPC-7_Human1.67924979
30MYB_26560356_Chip-Seq_TH1_Human1.66842962
31SPI1_23547873_ChIP-Seq_NB4_Human1.66414586
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60704307
33PU_27001747_Chip-Seq_BMDM_Mouse1.59820013
34SPI1_23127762_ChIP-Seq_K562_Human1.59380454
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51090455
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50911250
37VDR_24763502_ChIP-Seq_THP-1_Human1.47548819
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44627474
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.44455463
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.43240718
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42362195
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39437541
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.37156249
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.36172893
45VDR_24787735_ChIP-Seq_THP-1_Human1.34795745
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34502160
47CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32721243
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32263320
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.31043002
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30958428
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.27777708
52VDR_21846776_ChIP-Seq_THP-1_Human1.27702062
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23833500
54GATA3_27048872_Chip-Seq_THYMUS_Human1.23683720
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20994190
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20531818
57UTX_26944678_Chip-Seq_JUKART_Human1.19812076
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17742703
59GATA3_26560356_Chip-Seq_TH2_Human1.17730697
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11144814
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06918072
62* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05012509
63TCF7_22412390_ChIP-Seq_EML_Mouse1.03949925
64FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00734728
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99002261
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98976023
67MAF_26560356_Chip-Seq_TH2_Human0.97725895
68CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95757458
69ELK3_25401928_ChIP-Seq_HUVEC_Human0.95135143
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94562876
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94242486
72KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92593593
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91190377
74FOXO3_23340844_ChIP-Seq_DLD1_Human0.90815753
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88711025
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88476889
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87487863
78FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86549426
79* GATA1_19941827_ChIP-Seq_MEL_Mouse0.86040148
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86022802
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85681151
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85352488
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83516810
84EGR1_19032775_ChIP-ChIP_M12_Human0.83042086
85SMRT_27268052_Chip-Seq_Bcells_Human0.81965576
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81804243
87KDM2B_26808549_Chip-Seq_DND41_Human0.78298130
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77303466
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77257770
90GATA2_19941826_ChIP-Seq_K562_Human0.76967367
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76709843
92MYC_22102868_ChIP-Seq_BL_Human0.76576347
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75917746
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75563751
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75563751
96* SOX2_20726797_ChIP-Seq_SW620_Human0.75452987
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74436810
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74319211
99GATA1_19941826_ChIP-Seq_K562_Human0.74098031
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.74061112
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73109521
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72914885
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.69716658
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68117836
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68113279
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67621032
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67603996
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.67236376
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.66233006
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.65609361
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65000196
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63207440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.23813703
2MP0009785_altered_susceptibility_to3.82278657
3MP0003303_peritoneal_inflammation3.33720731
4MP0003436_decreased_susceptibility_to3.27557033
5MP0000685_abnormal_immune_system3.26817400
6MP0001790_abnormal_immune_system3.18512141
7MP0005387_immune_system_phenotype3.18512141
8MP0005025_abnormal_response_to2.92686096
9MP0005000_abnormal_immune_tolerance2.86278345
10MP0003724_increased_susceptibility_to2.86187229
11MP0002419_abnormal_innate_immunity2.77837020
12MP0004510_myositis2.77726271
13MP0006082_CNS_inflammation2.75646598
14MP0002148_abnormal_hypersensitivity_rea2.72643490
15MP0001800_abnormal_humoral_immune2.71536586
16MP0002452_abnormal_antigen_presenting2.58925076
17MP0002723_abnormal_immune_serum2.50380496
18MP0005671_abnormal_response_to2.45426514
19MP0005058_abnormal_lysosome_morphology2.45334434
20MP0004947_skin_inflammation2.27365072
21MP0001819_abnormal_immune_cell2.17522194
22MP0000569_abnormal_digit_pigmentation2.14300858
23MP0002420_abnormal_adaptive_immunity2.12769251
24MP0005464_abnormal_platelet_physiology1.92010359
25MP0005451_abnormal_body_composition1.90444778
26MP0010155_abnormal_intestine_physiology1.87896692
27MP0009840_abnormal_foam_cell1.86466638
28MP0001533_abnormal_skeleton_physiology1.85990607
29MP0003172_abnormal_lysosome_physiology1.85636670
30MP0009764_decreased_sensitivity_to1.83953360
31MP0002166_altered_tumor_susceptibility1.83836161
32MP0003300_gastrointestinal_ulcer1.81416379
33MP0001845_abnormal_inflammatory_respons1.81164001
34MP0008469_abnormal_protein_level1.77010469
35MP0001853_heart_inflammation1.76754173
36MP0002006_tumorigenesis1.76683434
37MP0009278_abnormal_bone_marrow1.75812563
38MP0002405_respiratory_system_inflammati1.73136805
39MP0000716_abnormal_immune_system1.64172151
40MP0002398_abnormal_bone_marrow1.61350219
41MP0003448_altered_tumor_morphology1.60039270
42MP0003191_abnormal_cellular_cholesterol1.58390865
43MP0000604_amyloidosis1.50004686
44MP0004883_abnormal_blood_vessel1.42654828
45MP0001545_abnormal_hematopoietic_system1.42400532
46MP0005397_hematopoietic_system_phenotyp1.42400532
47MP0005310_abnormal_salivary_gland1.37794208
48MP0000689_abnormal_spleen_morphology1.34611246
49MP0002998_abnormal_bone_remodeling1.32856412
50MP0002429_abnormal_blood_cell1.30642435
51MP0008260_abnormal_autophagy1.28483774
52MP0002254_reproductive_system_inflammat1.27817709
53MP0000343_altered_response_to1.26987544
54MP0003075_altered_response_to1.24273619
55MP0003763_abnormal_thymus_physiology1.24027078
56MP0010307_abnormal_tumor_latency1.23934731
57MP0009763_increased_sensitivity_to1.22405459
58MP0002722_abnormal_immune_system1.21587649
59MP0009333_abnormal_splenocyte_physiolog1.21464862
60MP0002138_abnormal_hepatobiliary_system1.21324956
61MP0000465_gastrointestinal_hemorrhage1.18904683
62MP0005083_abnormal_biliary_tract1.14718478
63MP0002332_abnormal_exercise_endurance1.13555958
64MP0001873_stomach_inflammation1.13039043
65MP0003183_abnormal_peptide_metabolism1.12337412
66MP0005360_urolithiasis1.07670864
67MP0000858_altered_metastatic_potential1.07179735
68MP0005167_abnormal_blood-brain_barrier1.06889699
69MP0006054_spinal_hemorrhage1.06097251
70MP0005166_decreased_susceptibility_to1.05053456
71MP0004808_abnormal_hematopoietic_stem1.03795122
72MP0004381_abnormal_hair_follicle1.03322982
73MP0003091_abnormal_cell_migration1.03193283
74MP0008004_abnormal_stomach_pH1.01001672
75MP0005076_abnormal_cell_differentiation0.95022781
76MP0005174_abnormal_tail_pigmentation0.94456924
77MP0003453_abnormal_keratinocyte_physiol0.93165892
78MP0003690_abnormal_glial_cell0.90289583
79MP0004782_abnormal_surfactant_physiolog0.88127649
80MP0000609_abnormal_liver_physiology0.87853672
81MP0003566_abnormal_cell_adhesion0.87489384
82MP0000371_diluted_coat_color0.85683476
83MP0003045_fibrosis0.84071091
84MP0005164_abnormal_response_to0.83844835
85MP0010352_gastrointestinal_tract_polyps0.82513019
86MP0001851_eye_inflammation0.82006882
87MP0002933_joint_inflammation0.81094554
88MP0000249_abnormal_blood_vessel0.80454038
89MP0003705_abnormal_hypodermis_morpholog0.78356272
90MP0005390_skeleton_phenotype0.77319135
91MP0003828_pulmonary_edema0.77004257
92MP0002139_abnormal_hepatobiliary_system0.76792026
93MP0002277_abnormal_respiratory_mucosa0.76386208
94MP0001663_abnormal_digestive_system0.76162922
95MP0009765_abnormal_xenobiotic_induced0.75390041
96MP0000703_abnormal_thymus_morphology0.74019433
97MP0002136_abnormal_kidney_physiology0.73636893
98MP0003866_abnormal_defecation0.72991263
99MP0003221_abnormal_cardiomyocyte_apopto0.72383363
100MP0008057_abnormal_DNA_replication0.71560027
101MP0005023_abnormal_wound_healing0.70069865
102MP0002396_abnormal_hematopoietic_system0.69896961
103MP0000767_abnormal_smooth_muscle0.69447713
104MP0003656_abnormal_erythrocyte_physiolo0.69393664
105MP0001958_emphysema0.67077585
106MP0001881_abnormal_mammary_gland0.67034477
107MP0004858_abnormal_nervous_system0.66709094
108MP0005319_abnormal_enzyme/_coenzyme0.63945743
109MP0003195_calcinosis0.62719422
110MP0005075_abnormal_melanosome_morpholog0.61963847
111MP0003806_abnormal_nucleotide_metabolis0.61674385
112MP0008874_decreased_physiological_sensi0.60166648
113MP0003795_abnormal_bone_structure0.59853445
114MP0002132_abnormal_respiratory_system0.59545695
115MP0002877_abnormal_melanocyte_morpholog0.59148576
116MP0000015_abnormal_ear_pigmentation0.58635015
117MP0000598_abnormal_liver_morphology0.57825014

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.63984646
2Eczematoid dermatitis (HP:0000976)5.55484610
3Recurrent bacterial skin infections (HP:0005406)5.37574502
4Autoimmune thrombocytopenia (HP:0001973)4.79592495
5Recurrent gram-negative bacterial infections (HP:0005420)4.61199986
6Myositis (HP:0100614)4.55683151
7Orchitis (HP:0100796)4.52718933
8Mediastinal lymphadenopathy (HP:0100721)4.44638941
9Optic neuritis (HP:0100653)4.43915517
10Retrobulbar optic neuritis (HP:0100654)4.43915517
11Abnormality of macrophages (HP:0004311)4.41114094
12Chronic otitis media (HP:0000389)4.39982471
13Elevated erythrocyte sedimentation rate (HP:0003565)4.24462846
14Recurrent viral infections (HP:0004429)4.11108133
15Recurrent fungal infections (HP:0002841)3.89761254
16Vasculitis (HP:0002633)3.78048718
17Recurrent skin infections (HP:0001581)3.72479728
18Systemic lupus erythematosus (HP:0002725)3.50590359
19Vacuolated lymphocytes (HP:0001922)3.45381142
20Gingivitis (HP:0000230)3.38260466
21Nasal polyposis (HP:0100582)3.30927759
22Basal ganglia calcification (HP:0002135)3.27170950
23Stomatitis (HP:0010280)3.26375547
24Increased cerebral lipofuscin (HP:0011813)3.25728696
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.23175132
26Pulmonary infiltrates (HP:0002113)3.18922436
27Arterial thrombosis (HP:0004420)3.17032202
28Periodontitis (HP:0000704)3.16752918
29Increased IgM level (HP:0003496)3.13282847
30Abnormality of the nasal mucosa (HP:0000433)3.10081285
31Chronic mucocutaneous candidiasis (HP:0002728)3.09387286
32Recurrent cutaneous fungal infections (HP:0011370)3.09387286
33Myocardial infarction (HP:0001658)3.01151131
34Recurrent bronchitis (HP:0002837)2.97123353
35Gingival bleeding (HP:0000225)2.96823497
36Pustule (HP:0200039)2.96755713
37Hematochezia (HP:0002573)2.95265733
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.94756591
39Porencephaly (HP:0002132)2.89947860
40Thick nail (HP:0001805)2.83540972
41Hypergammaglobulinemia (HP:0010702)2.80969410
42Keratoconjunctivitis sicca (HP:0001097)2.78162603
43Prostate neoplasm (HP:0100787)2.73443987
44Premature loss of primary teeth (HP:0006323)2.72184239
45Tetraparesis (HP:0002273)2.65065941
46Hemoptysis (HP:0002105)2.63526287
47Cellulitis (HP:0100658)2.63326642
48Interstitial pulmonary disease (HP:0006530)2.63313335
49Colitis (HP:0002583)2.60449141
50Osteomyelitis (HP:0002754)2.57839359
51Gastrointestinal infarctions (HP:0005244)2.55464771
52Obstructive lung disease (HP:0006536)2.53485179
53Chronic obstructive pulmonary disease (HP:0006510)2.53485179
54Keratoconjunctivitis (HP:0001096)2.52670693
55Abnormality of liposaccharide metabolism (HP:0010968)2.50978069
56Abnormality of glycosphingolipid metabolism (HP:0004343)2.50978069
57Abnormality of glycolipid metabolism (HP:0010969)2.50978069
58Meningitis (HP:0001287)2.50270620
59Glomerulonephritis (HP:0000099)2.49173704
60Increased IgE level (HP:0003212)2.49089740
61Panhypogammaglobulinemia (HP:0003139)2.45315425
62Leukocytosis (HP:0001974)2.44237783
63Abnormality of T cell number (HP:0011839)2.43529906
64Chronic sinusitis (HP:0011109)2.37841903
65Joint swelling (HP:0001386)2.37737897
66Abnormality of the pleura (HP:0002103)2.37462739
67Osteolytic defects of the hand bones (HP:0009699)2.37039804
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.37039804
69Axonal loss (HP:0003447)2.34943431
70Esophageal varix (HP:0002040)2.31287388
71Loss of speech (HP:0002371)2.30810140
72Viral hepatitis (HP:0006562)2.30212353
73Nephritis (HP:0000123)2.30013744
74Eosinophilia (HP:0001880)2.25716440
75Abnormality of T cell physiology (HP:0011840)2.25712318
76Inflammation of the large intestine (HP:0002037)2.25368230
77Spontaneous hematomas (HP:0007420)2.25196511
78T lymphocytopenia (HP:0005403)2.23090267
79Abnormality of the peritoneum (HP:0002585)2.20684531
80Emphysema (HP:0002097)2.19891677
81Abnormal delayed hypersensitivity skin test (HP:0002963)2.19756669
82Urticaria (HP:0001025)2.19613271
83Anorexia (HP:0002039)2.18647065
84Abnormality of the endocardium (HP:0004306)2.18420656
85Autoimmune hemolytic anemia (HP:0001890)2.17351302
86Abnormality of B cell number (HP:0010975)2.17135934
87Frequent falls (HP:0002359)2.15374984
88Gastrointestinal inflammation (HP:0004386)2.14677030
89Prolonged bleeding time (HP:0003010)2.13892797
90Plagiocephaly (HP:0001357)2.13038330
91Abnormality of cells of the lymphoid lineage (HP:0012140)2.12797668
92Lymphopenia (HP:0001888)2.12657862
93Joint hemorrhage (HP:0005261)2.12539195
94Bone pain (HP:0002653)2.10160769
95Amyloidosis (HP:0011034)2.07190419
96Slow saccadic eye movements (HP:0000514)2.04701224
97Abnormality of eosinophils (HP:0001879)2.03983861
98Recurrent pneumonia (HP:0006532)2.01481361
99Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00500686
100Skin ulcer (HP:0200042)1.99967953
101Cheilitis (HP:0100825)1.99828869
102Malnutrition (HP:0004395)1.99737949
103IgG deficiency (HP:0004315)1.99443824
104IgM deficiency (HP:0002850)1.99141742
105Agammaglobulinemia (HP:0004432)1.99056092
106Epistaxis (HP:0000421)1.99016771
107IgA deficiency (HP:0002720)1.98598861
108Glomerulopathy (HP:0100820)1.98573745
109Pulmonary embolism (HP:0002204)1.98330767
110Chest pain (HP:0100749)1.96212481
111Gastrointestinal stroma tumor (HP:0100723)1.96098874
112Abnormality of T cells (HP:0002843)1.95972641
113Thrombophlebitis (HP:0004418)1.95787374
114Polyneuropathy (HP:0001271)1.94710881
115Arthralgia (HP:0002829)1.94380245
116Acute hepatic failure (HP:0006554)1.94262556
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93830527
118Subacute progressive viral hepatitis (HP:0006572)1.93719299
119Abnormality of the pericardium (HP:0001697)1.92702662
120Vertigo (HP:0002321)1.92601832
121Disinhibition (HP:0000734)1.91579851
122Chronic diarrhea (HP:0002028)1.91277528
123Encephalitis (HP:0002383)1.91028461
124Keratitis (HP:0000491)1.89462187
125Peritonitis (HP:0002586)1.88569391
126Granulocytopenia (HP:0001913)1.87099325
127Complement deficiency (HP:0004431)1.85538837
128Gangrene (HP:0100758)1.85382530
129Recurrent lower respiratory tract infections (HP:0002783)1.85111090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.73031176
2MAP3K144.15853279
3IKBKE3.98334248
4TBK13.61449473
5JAK33.32486453
6JAK13.22565838
7IRAK33.04496385
8RIPK43.03225313
9MAP4K12.80124235
10IRAK42.71184868
11MAP3K132.66443537
12BLK2.66405866
13FGFR42.54009145
14KIT2.49816900
15ERN12.21902079
16IKBKB2.21010252
17TXK2.05895630
18PRPF4B1.87190430
19FGFR31.69768797
20EPHB11.58784369
21CSK1.55960787
22CHUK1.53913096
23TAOK31.43186061
24ZAP701.42643145
25MAP3K101.36909174
26SYK1.28638277
27PBK1.28117093
28HCK1.27611340
29JAK21.25638146
30GRK71.19764610
31LCK1.18570528
32CDC42BPA1.16402219
33EPHA31.15315809
34PIK3CG1.13457131
35CSF1R1.05358789
36PIM21.02229598
37MARK31.01265886
38RPS6KA40.99870274
39FGR0.98485396
40TTN0.98424331
41BTK0.96459622
42PTK60.96220479
43STK100.96213901
44CDK120.95735910
45TGFBR20.95685390
46IRAK10.93658053
47RIPK10.93356075
48SIK20.92711072
49FES0.89347653
50CAMK1D0.89218858
51PIM10.89154466
52TNK20.85661085
53LYN0.85439504
54MAP3K20.82327216
55EIF2AK20.79331721
56NEK90.78290077
57SIK10.75305436
58ACVR1B0.73861810
59TEC0.73237432
60STK40.71986754
61TAOK10.71443720
62MST40.70933831
63MAP3K50.69660208
64ITK0.69316994
65EGFR0.69276115
66HIPK20.68096326
67MATK0.67243771
68PTK2B0.66518859
69MST1R0.62760662
70DAPK20.62759820
71STK30.61843941
72MAP3K110.61154215
73TAOK20.60679098
74MARK20.60276028
75BMX0.59951218
76CAMKK20.56724841
77MAPK70.56525490
78MAP3K60.55278110
79SGK20.54059727
80TRPM70.53917055
81IRAK20.53672653
82ABL10.53436070
83FRK0.52589813
84MELK0.52471425
85PRKCQ0.51738800
86LRRK20.51225322
87CAMK1G0.50997212
88TRIB30.50028496
89NLK0.47714007
90BMPR20.45956569
91CDK60.45918007
92WNK10.45326194
93PKN20.44687731
94SIK30.44630795
95GRK60.44500158
96NME20.44157560
97MAPK110.42768798
98KSR20.42264590
99KDR0.41671226
100MAP2K30.40011324
101DDR20.38600515
102YES10.38020885
103PRKCD0.37762215
104MAP3K70.37325154
105MAP2K60.35987308
106PDGFRB0.35358695
107DAPK30.33734999
108PDK10.32735745
109NUAK10.31235730
110CLK10.30964464
111PDPK10.30849573
112PKN10.30712029
113FYN0.29887246
114RET0.29850555
115SGK30.29816120
116MAP3K30.29635918
117MOS0.27667655
118RPS6KA50.26756625
119STK240.25622229
120FLT30.23362669
121IGF1R0.22495414
122PRKAA20.22489727
123CDK40.21673109
124PRKG20.21611439
125INSR0.21421433
126ABL20.21221307
127MAPKAPK20.20023859
128MAP3K10.19966876

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.02533993
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.91669745
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.89250171
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.89125371
5Staphylococcus aureus infection_Homo sapiens_hsa051502.85279448
6Measles_Homo sapiens_hsa051622.77278964
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.62902970
8Allograft rejection_Homo sapiens_hsa053302.45648136
9Influenza A_Homo sapiens_hsa051642.45207844
10Graft-versus-host disease_Homo sapiens_hsa053322.40137694
11Osteoclast differentiation_Homo sapiens_hsa043802.38180446
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32301570
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.11077238
14TNF signaling pathway_Homo sapiens_hsa046682.07208875
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05088198
16Malaria_Homo sapiens_hsa051442.00695931
17Pertussis_Homo sapiens_hsa051332.00330198
18Herpes simplex infection_Homo sapiens_hsa051681.98350123
19Caffeine metabolism_Homo sapiens_hsa002321.96034769
20Legionellosis_Homo sapiens_hsa051341.94993972
21Tuberculosis_Homo sapiens_hsa051521.93053545
22B cell receptor signaling pathway_Homo sapiens_hsa046621.86252941
23Toxoplasmosis_Homo sapiens_hsa051451.76893057
24Hepatitis C_Homo sapiens_hsa051601.69313250
25Primary immunodeficiency_Homo sapiens_hsa053401.67861550
26African trypanosomiasis_Homo sapiens_hsa051431.54583587
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.49840065
28Rheumatoid arthritis_Homo sapiens_hsa053231.49790529
29Asthma_Homo sapiens_hsa053101.46521950
30Antigen processing and presentation_Homo sapiens_hsa046121.43484668
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40412213
32Apoptosis_Homo sapiens_hsa042101.38625239
33Hepatitis B_Homo sapiens_hsa051611.37261441
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32959775
35Hematopoietic cell lineage_Homo sapiens_hsa046401.28577813
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26936338
37Type I diabetes mellitus_Homo sapiens_hsa049401.24815117
38Chemokine signaling pathway_Homo sapiens_hsa040621.24699044
39Lysosome_Homo sapiens_hsa041421.17769232
40Salmonella infection_Homo sapiens_hsa051321.17267497
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15531868
42T cell receptor signaling pathway_Homo sapiens_hsa046601.12125674
43Shigellosis_Homo sapiens_hsa051311.11674423
44Viral myocarditis_Homo sapiens_hsa054161.11474501
45Autoimmune thyroid disease_Homo sapiens_hsa053201.11045141
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10425670
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01026474
48Phagosome_Homo sapiens_hsa041450.99710300
49Prolactin signaling pathway_Homo sapiens_hsa049170.98023215
50Complement and coagulation cascades_Homo sapiens_hsa046100.97909943
51Acute myeloid leukemia_Homo sapiens_hsa052210.91749128
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.89890540
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.84991134
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83691907
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.83619952
56Non-small cell lung cancer_Homo sapiens_hsa052230.82294962
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82162116
58Amoebiasis_Homo sapiens_hsa051460.79604507
59Small cell lung cancer_Homo sapiens_hsa052220.78988157
60Chronic myeloid leukemia_Homo sapiens_hsa052200.78536479
61Type II diabetes mellitus_Homo sapiens_hsa049300.73872698
62Pancreatic cancer_Homo sapiens_hsa052120.70988026
63ABC transporters_Homo sapiens_hsa020100.69994185
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64538881
65Insulin resistance_Homo sapiens_hsa049310.63535169
66Other glycan degradation_Homo sapiens_hsa005110.61369802
67Renal cell carcinoma_Homo sapiens_hsa052110.54459334
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54273458
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.53874671
70Arginine biosynthesis_Homo sapiens_hsa002200.51786520
71Epstein-Barr virus infection_Homo sapiens_hsa051690.51370943
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51369961
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.50928171
74Platelet activation_Homo sapiens_hsa046110.48258215
75Viral carcinogenesis_Homo sapiens_hsa052030.46685930
76HIF-1 signaling pathway_Homo sapiens_hsa040660.46296808
77Systemic lupus erythematosus_Homo sapiens_hsa053220.44006344
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43858267
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42131297
80Notch signaling pathway_Homo sapiens_hsa043300.40493841
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39321659
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38936575
83Prion diseases_Homo sapiens_hsa050200.38662252
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38312837
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.36998815
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36797173
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36514908
88Dorso-ventral axis formation_Homo sapiens_hsa043200.36093560
89mTOR signaling pathway_Homo sapiens_hsa041500.35973770
90Inositol phosphate metabolism_Homo sapiens_hsa005620.35419030
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.32842064
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30737544
93Lysine degradation_Homo sapiens_hsa003100.30230524
94Endocytosis_Homo sapiens_hsa041440.30172696
95GnRH signaling pathway_Homo sapiens_hsa049120.29747745
96Endometrial cancer_Homo sapiens_hsa052130.29022594
97HTLV-I infection_Homo sapiens_hsa051660.28531552
98Renin-angiotensin system_Homo sapiens_hsa046140.26710033
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26588037
100Mineral absorption_Homo sapiens_hsa049780.26202487
101Choline metabolism in cancer_Homo sapiens_hsa052310.25900281
102PPAR signaling pathway_Homo sapiens_hsa033200.25564202
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25407219
104VEGF signaling pathway_Homo sapiens_hsa043700.24597311
105Proteoglycans in cancer_Homo sapiens_hsa052050.23834062
106MicroRNAs in cancer_Homo sapiens_hsa052060.23787880
107Bladder cancer_Homo sapiens_hsa052190.22753161
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22318289
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21405335
110MAPK signaling pathway_Homo sapiens_hsa040100.21031664
111FoxO signaling pathway_Homo sapiens_hsa040680.20305076
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19989443
113ErbB signaling pathway_Homo sapiens_hsa040120.19609520
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19265625
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15657853
116Vitamin digestion and absorption_Homo sapiens_hsa049770.14796810
117Prostate cancer_Homo sapiens_hsa052150.13809915
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12983049

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