PARP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.42821775
2nuclear pore organization (GO:0006999)5.10850361
3establishment of integrated proviral latency (GO:0075713)5.01108908
4nuclear pore complex assembly (GO:0051292)4.93980117
5protein localization to kinetochore (GO:0034501)4.73382466
6DNA replication initiation (GO:0006270)4.57277160
7DNA strand elongation involved in DNA replication (GO:0006271)4.54367457
8DNA replication-dependent nucleosome organization (GO:0034723)4.43855144
9DNA replication-dependent nucleosome assembly (GO:0006335)4.43855144
10mitotic nuclear envelope disassembly (GO:0007077)4.32599051
11DNA strand elongation (GO:0022616)4.31014035
12DNA topological change (GO:0006265)4.29334663
13regulation of histone H3-K9 methylation (GO:0051570)4.09002498
14nucleobase biosynthetic process (GO:0046112)4.07616286
15IMP biosynthetic process (GO:0006188)4.07339569
16folic acid-containing compound biosynthetic process (GO:0009396)4.04861144
17membrane disassembly (GO:0030397)4.03718189
18nuclear envelope disassembly (GO:0051081)4.03718189
19telomere maintenance via semi-conservative replication (GO:0032201)3.98899020
20DNA duplex unwinding (GO:0032508)3.96741588
21DNA geometric change (GO:0032392)3.96387754
22regulation of gene silencing by RNA (GO:0060966)3.94907787
23regulation of posttranscriptional gene silencing (GO:0060147)3.94907787
24regulation of gene silencing by miRNA (GO:0060964)3.94907787
25negative regulation of histone methylation (GO:0031061)3.92351148
26protein localization to chromosome, centromeric region (GO:0071459)3.91635081
27mitotic metaphase plate congression (GO:0007080)3.90931903
28protein complex localization (GO:0031503)3.88548830
29mitotic chromosome condensation (GO:0007076)3.87787997
30somatic hypermutation of immunoglobulin genes (GO:0016446)3.86559032
31somatic diversification of immune receptors via somatic mutation (GO:0002566)3.86559032
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.86396633
33mitotic sister chromatid segregation (GO:0000070)3.82821636
34pre-miRNA processing (GO:0031054)3.79422908
35DNA replication checkpoint (GO:0000076)3.76646586
36pore complex assembly (GO:0046931)3.74348922
37sister chromatid segregation (GO:0000819)3.73159277
38establishment of viral latency (GO:0019043)3.71662835
39formation of translation preinitiation complex (GO:0001731)3.71547571
40positive regulation of chromosome segregation (GO:0051984)3.71172869
41DNA ligation (GO:0006266)3.66641442
42purine nucleobase biosynthetic process (GO:0009113)3.66478219
43heterochromatin organization (GO:0070828)3.65491055
44mitotic recombination (GO:0006312)3.64380522
45telomere maintenance via recombination (GO:0000722)3.58462468
46non-recombinational repair (GO:0000726)3.57941408
47double-strand break repair via nonhomologous end joining (GO:0006303)3.57941408
48metaphase plate congression (GO:0051310)3.57548592
49L-serine metabolic process (GO:0006563)3.55929021
50regulation of helicase activity (GO:0051095)3.55838970
51negative regulation of mRNA metabolic process (GO:1903312)3.54583656
52regulation of translational fidelity (GO:0006450)3.54097868
53IMP metabolic process (GO:0046040)3.52490620
54regulation of spindle organization (GO:0090224)3.51173901
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51053993
56maturation of SSU-rRNA (GO:0030490)3.42174218
57kinetochore organization (GO:0051383)3.40069490
58mitotic sister chromatid cohesion (GO:0007064)3.39684952
59ribosome assembly (GO:0042255)3.38656779
60chromosome condensation (GO:0030261)3.34957708
61telomere maintenance via telomere lengthening (GO:0010833)3.34938881
62regulation of chromosome segregation (GO:0051983)3.31238918
63chromatin remodeling at centromere (GO:0031055)3.27867852
64cellular protein complex localization (GO:0034629)3.26786357
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.26651018
66negative regulation of chromosome segregation (GO:0051985)3.26053606
67DNA replication-independent nucleosome assembly (GO:0006336)3.25203403
68DNA replication-independent nucleosome organization (GO:0034724)3.25203403
69positive regulation of mitotic sister chromatid separation (GO:1901970)3.24184414
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24184414
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24184414
72peptidyl-arginine omega-N-methylation (GO:0035247)3.23378354
73ribosomal small subunit biogenesis (GO:0042274)3.23261778
74regulation of sister chromatid cohesion (GO:0007063)3.23015026
75attachment of spindle microtubules to kinetochore (GO:0008608)3.22858671
76chromatin assembly (GO:0031497)3.22609337
77DNA conformation change (GO:0071103)3.21782405
78translesion synthesis (GO:0019985)3.21698416
79dosage compensation (GO:0007549)3.21112636
80protein-DNA complex disassembly (GO:0032986)3.20619583
81nucleosome disassembly (GO:0006337)3.20619583
82establishment of chromosome localization (GO:0051303)3.20066114
83DNA synthesis involved in DNA repair (GO:0000731)3.19293812
84regulation of mitotic spindle organization (GO:0060236)3.19288616
85chromatin assembly or disassembly (GO:0006333)3.18227252
86negative regulation of mitotic sister chromatid separation (GO:2000816)3.17470050
87negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17470050
88negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17470050
89negative regulation of sister chromatid segregation (GO:0033046)3.17470050
90negative regulation of RNA splicing (GO:0033119)3.17050431
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16613582
92spindle assembly checkpoint (GO:0071173)3.16253899
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15858852
94regulation of centrosome cycle (GO:0046605)3.15422812
95nuclear envelope organization (GO:0006998)3.15331127
96mitotic spindle assembly checkpoint (GO:0007094)3.14230737
97histone exchange (GO:0043486)3.13576493
98histone arginine methylation (GO:0034969)3.12743367
99regulation of mitotic metaphase/anaphase transition (GO:0030071)3.12272406
100CENP-A containing nucleosome assembly (GO:0034080)3.12016217
101ribosome biogenesis (GO:0042254)3.11668874
102regulation of translational termination (GO:0006449)3.10356106
103postreplication repair (GO:0006301)3.10249181
104mRNA splicing, via spliceosome (GO:0000398)3.08478285
105RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.08478285
106protein localization to chromosome (GO:0034502)3.08361493
107spindle checkpoint (GO:0031577)3.08349558
108mitotic spindle checkpoint (GO:0071174)3.06918395
109negative regulation of mRNA processing (GO:0050686)3.06778779
110ribosomal small subunit assembly (GO:0000028)3.06671741
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06534822
112mismatch repair (GO:0006298)3.04826288
113RNA splicing, via transesterification reactions (GO:0000375)3.04116834
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03940586
115meiotic chromosome segregation (GO:0045132)3.03785686
116termination of RNA polymerase II transcription (GO:0006369)3.01860440
117protein K6-linked ubiquitination (GO:0085020)3.01325785
118spliceosomal tri-snRNP complex assembly (GO:0000244)3.01134561
119regulation of mitotic sister chromatid segregation (GO:0033047)3.00674493
120regulation of sister chromatid segregation (GO:0033045)3.00674493
121regulation of mitotic sister chromatid separation (GO:0010965)3.00674493
122ATP-dependent chromatin remodeling (GO:0043044)3.00553666
123chromosome segregation (GO:0007059)2.99777206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.93836673
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.98326958
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.96927246
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90562266
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23785512
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.19545229
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03493942
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68359394
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.51951030
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41512252
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31891555
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30282479
13* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28331220
14MYC_22102868_ChIP-Seq_BL_Human2.24870560
15XRN2_22483619_ChIP-Seq_HELA_Human2.18547060
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.17073929
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.13927943
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.12693919
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.05029696
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03264306
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.02335360
22AR_21909140_ChIP-Seq_LNCAP_Human2.01583629
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95607934
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94792453
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93356605
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91447536
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90516957
28* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88582628
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84718080
30CIITA_25753668_ChIP-Seq_RAJI_Human1.82172557
31* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77839564
32VDR_23849224_ChIP-Seq_CD4+_Human1.73352919
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.70608119
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66703604
35FOXP3_21729870_ChIP-Seq_TREG_Human1.65485333
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62835555
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58694069
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58694069
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58694069
40TTF2_22483619_ChIP-Seq_HELA_Human1.57871766
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57768301
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51457430
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50175564
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50041283
45GABP_19822575_ChIP-Seq_HepG2_Human1.49957218
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.49415373
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49173285
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.47924874
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.47138567
50DCP1A_22483619_ChIP-Seq_HELA_Human1.44842396
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40099268
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38353767
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38210588
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32902779
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30475672
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30177975
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27622713
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25944926
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25263430
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25070679
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24929210
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24672825
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24106934
64NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23687488
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20330864
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.20119730
67VDR_21846776_ChIP-Seq_THP-1_Human1.19855855
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19462866
69* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19034462
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17990568
71ELK1_19687146_ChIP-ChIP_HELA_Human1.16547268
72* NANOG_21062744_ChIP-ChIP_HESCs_Human1.16385828
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16081950
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15509948
75* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15509416
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15134117
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13807323
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13139107
79TFEB_21752829_ChIP-Seq_HELA_Human1.12123421
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08803441
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08636030
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08525665
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08177826
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07803030
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07378298
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06874530
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05669545
88CHD1_26751641_Chip-Seq_LNCaP_Human1.04282511
89* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02837620
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02541155
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02524527
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02000079
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01200760
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98376944
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96405583
96CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95734293
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95254415
98MYC_18940864_ChIP-ChIP_HL60_Human0.94081491
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.93406684
100SRF_21415370_ChIP-Seq_HL-1_Mouse0.93220108
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.89569388
102* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89215821
103* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89136093
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.88167457
105* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87152806
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87026995
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86147065
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85728355
109* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84274269
110* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83282291
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83152897
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81554562
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80384648
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76668314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62960752
2* MP0010094_abnormal_chromosome_stability4.61369526
3* MP0003111_abnormal_nucleus_morphology4.40368412
4MP0004957_abnormal_blastocyst_morpholog4.24462685
5MP0008057_abnormal_DNA_replication4.18578862
6* MP0003077_abnormal_cell_cycle3.91618760
7* MP0008058_abnormal_DNA_repair2.84411002
8MP0010352_gastrointestinal_tract_polyps2.81012724
9MP0003123_paternal_imprinting2.79574017
10MP0008877_abnormal_DNA_methylation2.76094922
11* MP0001730_embryonic_growth_arrest2.69399110
12MP0008007_abnormal_cellular_replicative2.54742303
13* MP0000350_abnormal_cell_proliferation2.43159333
14MP0010307_abnormal_tumor_latency2.40571693
15MP0008932_abnormal_embryonic_tissue2.40420613
16MP0001672_abnormal_embryogenesis/_devel2.12895208
17MP0005380_embryogenesis_phenotype2.12895208
18MP0002396_abnormal_hematopoietic_system2.06111987
19MP0005076_abnormal_cell_differentiation2.05121940
20MP0002084_abnormal_developmental_patter2.02013823
21MP0001697_abnormal_embryo_size1.99276735
22MP0002085_abnormal_embryonic_tissue1.97811265
23MP0004197_abnormal_fetal_growth/weight/1.94846097
24MP0003984_embryonic_growth_retardation1.92673200
25MP0002088_abnormal_embryonic_growth/wei1.89481481
26MP0003121_genomic_imprinting1.88118328
27MP0003786_premature_aging1.81885643
28* MP0002080_prenatal_lethality1.80918298
29MP0002086_abnormal_extraembryonic_tissu1.77099432
30MP0003890_abnormal_embryonic-extraembry1.67175035
31MP0002653_abnormal_ependyma_morphology1.62284684
32MP0000537_abnormal_urethra_morphology1.61744998
33MP0003567_abnormal_fetal_cardiomyocyte1.60380244
34MP0001293_anophthalmia1.57336047
35MP0001346_abnormal_lacrimal_gland1.56261731
36MP0002877_abnormal_melanocyte_morpholog1.53676311
37MP0009697_abnormal_copulation1.51150981
38MP0003119_abnormal_digestive_system1.43764273
39* MP0000313_abnormal_cell_death1.42053449
40MP0002009_preneoplasia1.41491663
41MP0004808_abnormal_hematopoietic_stem1.41266300
42MP0002210_abnormal_sex_determination1.39451732
43MP0000490_abnormal_crypts_of1.37417147
44MP0010030_abnormal_orbit_morphology1.37016824
45MP0002019_abnormal_tumor_incidence1.36273274
46MP0003705_abnormal_hypodermis_morpholog1.32627182
47MP0001145_abnormal_male_reproductive1.26651004
48MP0004133_heterotaxia1.24797387
49MP0004185_abnormal_adipocyte_glucose1.23611766
50MP0009053_abnormal_anal_canal1.22921725
51MP0000566_synostosis1.22008997
52MP0009278_abnormal_bone_marrow1.21359685
53MP0003806_abnormal_nucleotide_metabolis1.15727068
54MP0009672_abnormal_birth_weight1.15226735
55MP0000678_abnormal_parathyroid_gland1.13304669
56MP0003283_abnormal_digestive_organ1.11864521
57MP0001661_extended_life_span1.11115100
58MP0001929_abnormal_gametogenesis1.09354093
59MP0006035_abnormal_mitochondrial_morpho1.08194270
60MP0000703_abnormal_thymus_morphology1.07057603
61MP0001188_hyperpigmentation1.06641028
62MP0009703_decreased_birth_body1.03965172
63MP0001915_intracranial_hemorrhage1.01087640
64MP0000653_abnormal_sex_gland1.00314151
65MP0001849_ear_inflammation0.97236697
66MP0002092_abnormal_eye_morphology0.95657838
67MP0003937_abnormal_limbs/digits/tail_de0.95496333
68MP0003315_abnormal_perineum_morphology0.95280488
69MP0003718_maternal_effect0.95069059
70MP0004233_abnormal_muscle_weight0.94906542
71MP0002111_abnormal_tail_morphology0.93365767
72MP0003566_abnormal_cell_adhesion0.92283820
73MP0002938_white_spotting0.90972047
74MP0000428_abnormal_craniofacial_morphol0.90233475
75MP0002697_abnormal_eye_size0.89308042
76MP0005397_hematopoietic_system_phenotyp0.89297876
77MP0001545_abnormal_hematopoietic_system0.89297876
78MP0000049_abnormal_middle_ear0.89012862
79MP0003861_abnormal_nervous_system0.87568130
80MP0005384_cellular_phenotype0.86304767
81MP0002249_abnormal_larynx_morphology0.84804560
82MP0005623_abnormal_meninges_morphology0.84777529
83MP0002398_abnormal_bone_marrow0.83332232
84MP0005621_abnormal_cell_physiology0.82903617
85MP0005187_abnormal_penis_morphology0.82199437
86MP0010234_abnormal_vibrissa_follicle0.82053398
87MP0003385_abnormal_body_wall0.81387090
88MP0002233_abnormal_nose_morphology0.81186491
89MP0002722_abnormal_immune_system0.80891597
90MP0002160_abnormal_reproductive_system0.80273707
91MP0005501_abnormal_skin_physiology0.79708037
92MP0003115_abnormal_respiratory_system0.78732953
93MP0000689_abnormal_spleen_morphology0.76676054
94MP0001286_abnormal_eye_development0.76668863
95MP0000733_abnormal_muscle_development0.75657734
96MP0000358_abnormal_cell_content/0.74920968
97MP0002925_abnormal_cardiovascular_devel0.73650942
98MP0003942_abnormal_urinary_system0.72568143
99MP0002081_perinatal_lethality0.72009794
100MP0006292_abnormal_olfactory_placode0.71643513
101MP0003136_yellow_coat_color0.70871237
102MP0003938_abnormal_ear_development0.70603799
103MP0003935_abnormal_craniofacial_develop0.69270092
104MP0000579_abnormal_nail_morphology0.67904124
105MP0008770_decreased_survivor_rate0.67832356
106MP0003941_abnormal_skin_development0.66482143
107MP0002075_abnormal_coat/hair_pigmentati0.66139896
108MP0000432_abnormal_head_morphology0.66057718
109MP0000477_abnormal_intestine_morphology0.65810796
110MP0003221_abnormal_cardiomyocyte_apopto0.65125004
111MP0000371_diluted_coat_color0.64246541
112MP0010630_abnormal_cardiac_muscle0.63985039
113MP0004264_abnormal_extraembryonic_tissu0.63487545
114MP0003787_abnormal_imprinting0.62750351
115MP0008995_early_reproductive_senescence0.62567757
116MP0002796_impaired_skin_barrier0.61006628
117MP0005389_reproductive_system_phenotype0.60896659
118MP0006036_abnormal_mitochondrial_physio0.60828527
119MP0003698_abnormal_male_reproductive0.60471787
120MP0009379_abnormal_foot_pigmentation0.60421331
121MP0000266_abnormal_heart_morphology0.59988587
122MP0001119_abnormal_female_reproductive0.59698797
123MP0001299_abnormal_eye_distance/0.59483214
124MP0003755_abnormal_palate_morphology0.59320335
125MP0002429_abnormal_blood_cell0.59110412
126MP0009333_abnormal_splenocyte_physiolog0.58633307
127MP0006054_spinal_hemorrhage0.58177360
128MP0003763_abnormal_thymus_physiology0.57543152
129MP0002114_abnormal_axial_skeleton0.55316269

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.99040785
2Medulloblastoma (HP:0002885)4.13361875
3Colon cancer (HP:0003003)3.82518759
4Chromsome breakage (HP:0040012)3.70526270
5Birth length less than 3rd percentile (HP:0003561)3.59098782
6Abnormality of the astrocytes (HP:0100707)3.55819101
7Astrocytoma (HP:0009592)3.55819101
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48311883
9Selective tooth agenesis (HP:0001592)3.42612933
10Agnosia (HP:0010524)3.39157795
11Multiple enchondromatosis (HP:0005701)3.23588512
12Rhabdomyosarcoma (HP:0002859)3.23522691
13Reticulocytopenia (HP:0001896)3.21146951
14Abnormality of the labia minora (HP:0012880)3.20559468
15Patellar aplasia (HP:0006443)3.19078601
16Cortical dysplasia (HP:0002539)3.14406103
17Glioma (HP:0009733)3.11927568
18Neoplasm of the oral cavity (HP:0100649)3.06032448
19Aplasia/Hypoplasia of the patella (HP:0006498)2.96854916
20Abnormality of chromosome stability (HP:0003220)2.95907066
21Increased nuchal translucency (HP:0010880)2.94025917
22Microvesicular hepatic steatosis (HP:0001414)2.91690100
23Abnormal number of incisors (HP:0011064)2.90706082
24Breast hypoplasia (HP:0003187)2.86696406
25Basal cell carcinoma (HP:0002671)2.82757562
26Progressive muscle weakness (HP:0003323)2.81890100
27Proximal placement of thumb (HP:0009623)2.79436296
28Neoplasm of striated muscle (HP:0009728)2.79382835
29Meckel diverticulum (HP:0002245)2.76555378
30Abnormality of the ileum (HP:0001549)2.69385577
31Volvulus (HP:0002580)2.68713309
32Nephroblastoma (Wilms tumor) (HP:0002667)2.68504568
33Impulsivity (HP:0100710)2.67359133
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.67167434
35Deviation of the thumb (HP:0009603)2.64599285
36Absent thumb (HP:0009777)2.63244601
37Degeneration of anterior horn cells (HP:0002398)2.62161678
38Abnormality of the anterior horn cell (HP:0006802)2.62161678
39Absent radius (HP:0003974)2.58594980
40Abnormality of cochlea (HP:0000375)2.57401050
41Carpal bone hypoplasia (HP:0001498)2.52368685
42Abnormality of the preputium (HP:0100587)2.50310433
43Duodenal stenosis (HP:0100867)2.49214205
44Small intestinal stenosis (HP:0012848)2.49214205
45Biliary tract neoplasm (HP:0100574)2.46089324
46Ectopic kidney (HP:0000086)2.45708114
47Missing ribs (HP:0000921)2.45524428
48Spastic diplegia (HP:0001264)2.45395111
49Progressive external ophthalmoplegia (HP:0000590)2.45189653
50Neoplasm of the pancreas (HP:0002894)2.44661761
51Embryonal renal neoplasm (HP:0011794)2.43426416
52Oral leukoplakia (HP:0002745)2.42556132
53Supernumerary spleens (HP:0009799)2.40583631
54Absent forearm bone (HP:0003953)2.40293283
55Aplasia involving forearm bones (HP:0009822)2.40293283
56Cafe-au-lait spot (HP:0000957)2.32579789
57Myelodysplasia (HP:0002863)2.31346013
58Duplication of thumb phalanx (HP:0009942)2.28467830
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27673570
60Short 4th metacarpal (HP:0010044)2.27673570
61Abnormality of glycolysis (HP:0004366)2.27271459
62Abnormality of cells of the erythroid lineage (HP:0012130)2.25951753
63Amaurosis fugax (HP:0100576)2.24880595
64Prominent nose (HP:0000448)2.24336672
6511 pairs of ribs (HP:0000878)2.23319380
66Abnormal lung lobation (HP:0002101)2.17193393
67Malignant gastrointestinal tract tumors (HP:0006749)2.16811768
68Gastrointestinal carcinoma (HP:0002672)2.16811768
69Abnormality of the carotid arteries (HP:0005344)2.16334432
70Atresia of the external auditory canal (HP:0000413)2.14758114
71Sloping forehead (HP:0000340)2.13814723
72Abnormality of the duodenum (HP:0002246)2.13459015
73Facial hemangioma (HP:0000329)2.11670747
74High pitched voice (HP:0001620)2.11507168
75Tracheoesophageal fistula (HP:0002575)2.10971525
76Facial cleft (HP:0002006)2.10542185
77Angiofibromas (HP:0010615)2.10428999
78Adenoma sebaceum (HP:0009720)2.10428999
79Overriding aorta (HP:0002623)2.09810288
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07591247
81Overlapping toe (HP:0001845)2.05648438
82Ovarian neoplasm (HP:0100615)2.04425131
83Triphalangeal thumb (HP:0001199)2.03193592
84Urethral obstruction (HP:0000796)2.03040078
85Insomnia (HP:0100785)2.02600335
86Hyperacusis (HP:0010780)2.02167784
87Macrocytic anemia (HP:0001972)2.01617077
88Morphological abnormality of the inner ear (HP:0011390)2.00770332
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.00379292
90Abnormal number of erythroid precursors (HP:0012131)2.00315965
91Rib fusion (HP:0000902)1.99270824
92Long eyelashes (HP:0000527)1.98110831
93Broad distal phalanx of finger (HP:0009836)1.98005733
94Neoplasm of the colon (HP:0100273)1.97744441
95Abnormality of homocysteine metabolism (HP:0010919)1.96774184
96Homocystinuria (HP:0002156)1.96774184
97High anterior hairline (HP:0009890)1.95394020
98Choanal atresia (HP:0000453)1.94336395
99Esophageal atresia (HP:0002032)1.93534890
100Embryonal neoplasm (HP:0002898)1.93497001
101Aplasia/hypoplasia of the humerus (HP:0006507)1.93238305
102Abnormality of the lower motor neuron (HP:0002366)1.92124118
103Renal duplication (HP:0000075)1.91109001
104Abnormality of chromosome segregation (HP:0002916)1.89604756
105Bone marrow hypocellularity (HP:0005528)1.88441888
106Squamous cell carcinoma (HP:0002860)1.87973130
107Duplicated collecting system (HP:0000081)1.87844170
108Increased serum pyruvate (HP:0003542)1.87521212
109Rough bone trabeculation (HP:0100670)1.87392557
110Horseshoe kidney (HP:0000085)1.87012128
111Abnormality of abdominal situs (HP:0011620)1.86924668
112Abdominal situs inversus (HP:0003363)1.86924668
113Supernumerary bones of the axial skeleton (HP:0009144)1.86298854
114Supernumerary ribs (HP:0005815)1.85333507
115Atrophy/Degeneration involving motor neurons (HP:0007373)1.85234396
116Skull defect (HP:0001362)1.84377507
117Short thumb (HP:0009778)1.83630662
118Calcaneovalgus deformity (HP:0001848)1.82846231
119Sandal gap (HP:0001852)1.82704837
120Pseudobulbar signs (HP:0002200)1.82485160
121Abnormality of the calcaneus (HP:0008364)1.82404365
122Spinal muscular atrophy (HP:0007269)1.81037223
123Septate vagina (HP:0001153)1.80670221
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80371538
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79757641
126Shoulder girdle muscle weakness (HP:0003547)1.79561783
127Cutaneous melanoma (HP:0012056)1.79494015
128Intestinal polyp (HP:0005266)1.78600862
129Abnormality of the salivary glands (HP:0010286)1.78465166
130Shawl scrotum (HP:0000049)1.78220078
131Abnormality of DNA repair (HP:0003254)1.78058185
132Obsessive-compulsive behavior (HP:0000722)1.77803517
133Trigonocephaly (HP:0000243)1.75933328
134Gout (HP:0001997)1.74356144
135Neoplasm of the adrenal cortex (HP:0100641)1.72084662
136Hepatoblastoma (HP:0002884)1.69217131
137Ragged-red muscle fibers (HP:0003200)1.67052559
138Premature ovarian failure (HP:0008209)1.65459194
139Deep philtrum (HP:0002002)1.65009443
140Trismus (HP:0000211)1.63899603
141Pallor (HP:0000980)1.59985359
142Short middle phalanx of the 5th finger (HP:0004220)1.59008660
143Elfin facies (HP:0004428)1.57735214
144Pancreatic islet-cell hyperplasia (HP:0004510)1.57592150
145Dysmetric saccades (HP:0000641)1.57081834
146Abnormal gallbladder physiology (HP:0012438)1.57000010
147Cholecystitis (HP:0001082)1.57000010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.62150783
2WEE13.95596667
3BUB13.63435846
4CDK123.61651158
5NEK23.14570261
6EEF2K3.03762439
7SMG12.97555127
8MAP3K102.72447968
9TSSK62.70228832
10VRK22.67185294
11TTK2.59132675
12PASK2.48602190
13NEK12.43280176
14RPS6KB22.22677614
15PBK2.14948092
16SRPK12.06718394
17PLK11.94216266
18ATR1.89818627
19PKN21.87324072
20TAF11.79969649
21CDK71.76662476
22CDK41.74394595
23BRD41.66465623
24EIF2AK11.63153468
25SCYL21.61712747
26CHEK11.53737709
27AURKB1.53692082
28EPHA21.52457019
29PLK31.51303626
30MKNK11.49653704
31ACVR1B1.49024887
32CHEK21.47601439
33MAP3K81.45569133
34TGFBR11.39971261
35BRSK21.39763340
36TLK11.39702291
37TESK21.38378939
38STK101.34859428
39PNCK1.29806969
40ALK1.29385038
41DYRK31.27928462
42PLK41.20607689
43PAK41.19592633
44STK41.17492622
45FLT31.15010617
46ATM1.11517621
47CDK21.11241295
48MKNK21.10059236
49AURKA1.09037115
50BRSK11.06356218
51MTOR0.97617613
52EIF2AK30.96283234
53STK160.94212594
54VRK10.93529738
55CAMK1G0.90741041
56NME10.88646614
57PIM10.87246584
58RPS6KA40.86431561
59CDK60.86179802
60MELK0.83579469
61ICK0.82928824
62CDK10.81626406
63CAMK1D0.75030946
64BRAF0.74192255
65TRIB30.72958246
66LRRK20.72282614
67MAP3K90.70389501
68ZAK0.70360775
69CSNK2A20.68891726
70EIF2AK20.68806832
71MAP4K10.68237727
72GRK60.66842602
73STK30.66308912
74CDK30.64565505
75PRKCI0.63363751
76PRPF4B0.62567994
77CDK11A0.60757494
78CSNK1D0.60228903
79CDK190.59090591
80KDR0.58185485
81CDK150.57818412
82CSNK1E0.57551732
83CDK180.56039118
84MAPKAPK30.55886788
85CSNK1G10.55091938
86PRKDC0.54729435
87AKT20.52467569
88CCNB10.52084495
89CSNK1G30.52060525
90PAK10.49509837
91CDK140.48925084
92CLK10.46479214
93CSNK2A10.45991599
94CDK90.45363527
95TNIK0.44589590
96KSR20.43886465
97FGFR10.43812652
98CSF1R0.42986749
99MAPK140.42859021
100PAK20.41735208
101PDK30.40618270
102PDK40.40618270
103NME20.40277151
104CSNK1A1L0.38689817
105DAPK10.37916497
106KSR10.37635691
107TRIM280.37369245
108MST40.36673551
109ARAF0.36353890
110DYRK20.35397810
111RAF10.35278676
112GSK3B0.34189128
113RPS6KB10.33545567
114LATS20.32987009
115AKT10.32071219
116PTK60.29755172
117FGFR40.29249091
118CSNK1G20.28912206
119PDK20.28611502
120FGFR20.27973509
121TESK10.27551644
122RPS6KA10.27457136
123TYRO30.27205840
124* MAPK10.26921587
125MAPK110.26174251
126RPS6KA50.25486551
127LATS10.23819508
128AKT30.22849054
129CDK80.22832357
130MARK30.22825326
131TTN0.22746275
132BTK0.22141731
133PDGFRA0.20356208
134TAOK20.19265516

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.01481564
2Mismatch repair_Homo sapiens_hsa034304.60144158
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64322565
4Spliceosome_Homo sapiens_hsa030403.53568821
5RNA transport_Homo sapiens_hsa030133.40587075
6One carbon pool by folate_Homo sapiens_hsa006703.04618079
7Cell cycle_Homo sapiens_hsa041102.98564435
8Homologous recombination_Homo sapiens_hsa034402.91922731
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91030876
10Nucleotide excision repair_Homo sapiens_hsa034202.84506312
11* Base excision repair_Homo sapiens_hsa034102.80773008
12RNA polymerase_Homo sapiens_hsa030202.42385618
13Non-homologous end-joining_Homo sapiens_hsa034502.38548733
14Ribosome_Homo sapiens_hsa030102.37013392
15Fanconi anemia pathway_Homo sapiens_hsa034602.33692332
16mRNA surveillance pathway_Homo sapiens_hsa030152.28641917
17Pyrimidine metabolism_Homo sapiens_hsa002401.92336210
18Proteasome_Homo sapiens_hsa030501.88863541
19RNA degradation_Homo sapiens_hsa030181.83083822
20Basal transcription factors_Homo sapiens_hsa030221.64947996
21p53 signaling pathway_Homo sapiens_hsa041151.52180966
22Systemic lupus erythematosus_Homo sapiens_hsa053221.49010968
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41950164
24Pyruvate metabolism_Homo sapiens_hsa006201.35192189
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33438952
26Viral carcinogenesis_Homo sapiens_hsa052031.26492026
27Oocyte meiosis_Homo sapiens_hsa041141.24924292
28Epstein-Barr virus infection_Homo sapiens_hsa051691.22429212
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18816393
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09374827
31Biosynthesis of amino acids_Homo sapiens_hsa012301.08156235
32Selenocompound metabolism_Homo sapiens_hsa004501.03170285
33Antigen processing and presentation_Homo sapiens_hsa046121.00330307
34MicroRNAs in cancer_Homo sapiens_hsa052060.99811819
35HTLV-I infection_Homo sapiens_hsa051660.96268066
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95489350
37Purine metabolism_Homo sapiens_hsa002300.95346988
38Herpes simplex infection_Homo sapiens_hsa051680.91301927
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90028942
40Basal cell carcinoma_Homo sapiens_hsa052170.89447641
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.83933746
42Notch signaling pathway_Homo sapiens_hsa043300.82998867
43Pentose phosphate pathway_Homo sapiens_hsa000300.79896164
44Hippo signaling pathway_Homo sapiens_hsa043900.77959678
45Thyroid cancer_Homo sapiens_hsa052160.76955999
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.74712549
47Colorectal cancer_Homo sapiens_hsa052100.74613498
48Small cell lung cancer_Homo sapiens_hsa052220.73382204
49Lysine degradation_Homo sapiens_hsa003100.72705010
50mTOR signaling pathway_Homo sapiens_hsa041500.71691300
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.70499708
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68591997
53Alcoholism_Homo sapiens_hsa050340.68128154
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66788588
55Huntingtons disease_Homo sapiens_hsa050160.64509561
56Chronic myeloid leukemia_Homo sapiens_hsa052200.63014862
57Fatty acid elongation_Homo sapiens_hsa000620.60154828
58Primary immunodeficiency_Homo sapiens_hsa053400.60125679
59Protein export_Homo sapiens_hsa030600.59696969
60Parkinsons disease_Homo sapiens_hsa050120.58832863
61Propanoate metabolism_Homo sapiens_hsa006400.58723574
62Hedgehog signaling pathway_Homo sapiens_hsa043400.58692889
63Carbon metabolism_Homo sapiens_hsa012000.57075199
64TGF-beta signaling pathway_Homo sapiens_hsa043500.53564662
65Arginine and proline metabolism_Homo sapiens_hsa003300.50759829
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50409812
67Adherens junction_Homo sapiens_hsa045200.49409385
68Steroid biosynthesis_Homo sapiens_hsa001000.48598778
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.48592762
70Non-small cell lung cancer_Homo sapiens_hsa052230.46710959
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45386970
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43415844
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43173745
74B cell receptor signaling pathway_Homo sapiens_hsa046620.42167653
75Pathways in cancer_Homo sapiens_hsa052000.42083008
76HIF-1 signaling pathway_Homo sapiens_hsa040660.41680675
77Legionellosis_Homo sapiens_hsa051340.41565317
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41108442
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40945267
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40282514
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39433888
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38664740
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38401908
84Hepatitis B_Homo sapiens_hsa051610.35350345
85Bladder cancer_Homo sapiens_hsa052190.34815177
86Endometrial cancer_Homo sapiens_hsa052130.34266877
87Prostate cancer_Homo sapiens_hsa052150.33613349
88Acute myeloid leukemia_Homo sapiens_hsa052210.33250868
89Viral myocarditis_Homo sapiens_hsa054160.32807127
90Fatty acid metabolism_Homo sapiens_hsa012120.32427634
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32018789
92Tight junction_Homo sapiens_hsa045300.31428445
93Fructose and mannose metabolism_Homo sapiens_hsa000510.31397855
94* Apoptosis_Homo sapiens_hsa042100.31347597
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29677170
96Wnt signaling pathway_Homo sapiens_hsa043100.29538903
97Folate biosynthesis_Homo sapiens_hsa007900.28761137
98Galactose metabolism_Homo sapiens_hsa000520.28286314
99Proteoglycans in cancer_Homo sapiens_hsa052050.26501375
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26284867
101Metabolic pathways_Homo sapiens_hsa011000.25647797
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22946414
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22913856
104Oxidative phosphorylation_Homo sapiens_hsa001900.22464333
105Arginine biosynthesis_Homo sapiens_hsa002200.22404612
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22123495
107FoxO signaling pathway_Homo sapiens_hsa040680.22034620
108Glutathione metabolism_Homo sapiens_hsa004800.22004870
109N-Glycan biosynthesis_Homo sapiens_hsa005100.21761870
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21665658
111Glioma_Homo sapiens_hsa052140.21422883
112Influenza A_Homo sapiens_hsa051640.21126356
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20223921
114Sulfur relay system_Homo sapiens_hsa041220.20064656
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.19830336
116Shigellosis_Homo sapiens_hsa051310.19496300
117Pancreatic cancer_Homo sapiens_hsa052120.19242629
118Insulin signaling pathway_Homo sapiens_hsa049100.18033397
119AMPK signaling pathway_Homo sapiens_hsa041520.17812772
120Measles_Homo sapiens_hsa051620.15743588
121Melanoma_Homo sapiens_hsa052180.14205356
122Glucagon signaling pathway_Homo sapiens_hsa049220.13596383
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12332826
124Vitamin B6 metabolism_Homo sapiens_hsa007500.12167934

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »