PARL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of DNA methylation (GO:0044030)5.11226239
2mitotic metaphase plate congression (GO:0007080)4.99020915
3proteasome assembly (GO:0043248)4.40972991
4DNA deamination (GO:0045006)4.38972951
5metaphase plate congression (GO:0051310)4.14335420
6negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.10878614
7DNA strand elongation involved in DNA replication (GO:0006271)4.08341646
8protein maturation by protein folding (GO:0022417)4.05367474
9CENP-A containing nucleosome assembly (GO:0034080)3.97130879
10ribosome assembly (GO:0042255)3.96080647
11DNA replication initiation (GO:0006270)3.93534289
12DNA strand elongation (GO:0022616)3.86875352
13DNA replication checkpoint (GO:0000076)3.83712435
14chromatin remodeling at centromere (GO:0031055)3.83277699
15establishment of chromosome localization (GO:0051303)3.80557191
16protein deneddylation (GO:0000338)3.77131308
17regulation of female gonad development (GO:2000194)3.75914289
18telomere maintenance via semi-conservative replication (GO:0032201)3.73913544
19regulation of retinoic acid receptor signaling pathway (GO:0048385)3.72893451
20attachment of spindle microtubules to kinetochore (GO:0008608)3.69247790
21maturation of 5.8S rRNA (GO:0000460)3.68949733
22formation of translation preinitiation complex (GO:0001731)3.66527876
23anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62736046
24rRNA modification (GO:0000154)3.60608501
25meiotic cell cycle (GO:0051321)3.59461102
26positive regulation of histone H3-K4 methylation (GO:0051571)3.59049061
27maturation of SSU-rRNA (GO:0030490)3.58656444
28DNA replication-dependent nucleosome assembly (GO:0006335)3.56319481
29DNA replication-dependent nucleosome organization (GO:0034723)3.56319481
30folic acid-containing compound biosynthetic process (GO:0009396)3.53568384
31DNA replication-independent nucleosome assembly (GO:0006336)3.52086804
32DNA replication-independent nucleosome organization (GO:0034724)3.52086804
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49170087
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48174968
35piRNA metabolic process (GO:0034587)3.44310534
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43885519
37telomere maintenance via recombination (GO:0000722)3.42395164
38ribosomal small subunit assembly (GO:0000028)3.41846795
39positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40464329
40nucleobase biosynthetic process (GO:0046112)3.36859868
41regulation of meiosis I (GO:0060631)3.34714759
42ribosome biogenesis (GO:0042254)3.31605148
43protein localization to kinetochore (GO:0034501)3.26804558
44mitotic nuclear envelope disassembly (GO:0007077)3.26331067
45establishment of viral latency (GO:0019043)3.26122562
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25973950
47cullin deneddylation (GO:0010388)3.25673159
48histone exchange (GO:0043486)3.24480205
49regulation of spindle organization (GO:0090224)3.23208977
50purine nucleobase biosynthetic process (GO:0009113)3.22317444
51L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22249622
52positive regulation of chromosome segregation (GO:0051984)3.20662999
53negative regulation of ligase activity (GO:0051352)3.18648620
54negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18648620
557-methylguanosine mRNA capping (GO:0006370)3.16994064
56rRNA methylation (GO:0031167)3.14247205
57base-excision repair (GO:0006284)3.13156485
587-methylguanosine RNA capping (GO:0009452)3.12926790
59RNA capping (GO:0036260)3.12926790
60protein K6-linked ubiquitination (GO:0085020)3.10541418
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10280035
62IMP metabolic process (GO:0046040)3.10041108
63spliceosomal snRNP assembly (GO:0000387)3.09706184
64mitotic recombination (GO:0006312)3.09143253
65regulation of spindle checkpoint (GO:0090231)3.08819745
66ribonucleoprotein complex biogenesis (GO:0022613)3.06341800
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.06082375
68telomere maintenance via telomere lengthening (GO:0010833)3.05859568
69base-excision repair, AP site formation (GO:0006285)3.05280769
70transcription-coupled nucleotide-excision repair (GO:0006283)3.04576401
71ribosomal large subunit biogenesis (GO:0042273)3.04454296
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04389000
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04389000
74protein localization to chromosome, centromeric region (GO:0071459)3.03941292
75chaperone-mediated protein transport (GO:0072321)3.03707653
76regulation of histone H3-K9 methylation (GO:0051570)3.02826824
77rRNA processing (GO:0006364)3.02784631
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02157744
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02157744
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02157744
81protein targeting to mitochondrion (GO:0006626)3.01458566
82cell cycle G1/S phase transition (GO:0044843)3.00939912
83G1/S transition of mitotic cell cycle (GO:0000082)3.00939912
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00263978
85mitotic chromosome condensation (GO:0007076)3.00170770
86DNA unwinding involved in DNA replication (GO:0006268)2.99276793
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.99084088
88regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98825537
89membrane disassembly (GO:0030397)2.98781768
90nuclear envelope disassembly (GO:0051081)2.98781768
91regulation of mitochondrial translation (GO:0070129)2.98641482
92positive regulation of ligase activity (GO:0051351)2.95604332
93kinetochore assembly (GO:0051382)2.95555388
94signal transduction involved in DNA damage checkpoint (GO:0072422)2.94348170
95signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94348170
96mitotic sister chromatid segregation (GO:0000070)2.94134820
97rRNA metabolic process (GO:0016072)2.93692486
98meiotic chromosome segregation (GO:0045132)2.93056048
99negative regulation of protein ubiquitination (GO:0031397)2.92393043
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91818154
101signal transduction involved in cell cycle checkpoint (GO:0072395)2.90205058
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89513075
103regulation of mitotic spindle checkpoint (GO:1903504)2.89513075
104kinetochore organization (GO:0051383)2.88981432
105regulation of cellular amino acid metabolic process (GO:0006521)2.88473827
106regulation of exit from mitosis (GO:0007096)2.88170088
107pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.88019655
108IMP biosynthetic process (GO:0006188)2.87544634
109chromatin assembly or disassembly (GO:0006333)2.86951428
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.84572964
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84525506
112regulation of cellular amine metabolic process (GO:0033238)2.84284964
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84037047
114transcription elongation from RNA polymerase III promoter (GO:0006385)2.82523531
115termination of RNA polymerase III transcription (GO:0006386)2.82523531
116spindle checkpoint (GO:0031577)2.81853693
117negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.79824662
118regulation of ubiquitin-protein transferase activity (GO:0051438)2.79225287
119regulation of double-strand break repair via homologous recombination (GO:0010569)2.77606223
120regulation of chromosome segregation (GO:0051983)2.77337315
121pseudouridine synthesis (GO:0001522)2.76598028
122female gamete generation (GO:0007292)2.75823704
123mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73967945
124oxidative phosphorylation (GO:0006119)2.73767801
125protein localization to mitochondrion (GO:0070585)2.73613848
126deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73410093
127establishment of integrated proviral latency (GO:0075713)2.72598166
128mitotic spindle checkpoint (GO:0071174)2.72081083
129pteridine-containing compound biosynthetic process (GO:0042559)2.71604286
130regulation of ligase activity (GO:0051340)2.71595678
131establishment of protein localization to mitochondrial membrane (GO:0090151)2.70755040
132negative regulation of chromosome segregation (GO:0051985)2.70052089
133negative regulation of sister chromatid segregation (GO:0033046)2.69816918
134negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69816918

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.42000322
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.08357383
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74897381
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38794436
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.38212505
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27561743
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17932015
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.17401094
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.16795742
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01919386
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.87295715
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84558450
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82525842
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82094557
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71775378
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60286519
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57054178
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51905866
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.38251441
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34660642
21* VDR_23849224_ChIP-Seq_CD4+_Human2.30052109
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24339848
23XRN2_22483619_ChIP-Seq_HELA_Human2.17567019
24AR_21909140_ChIP-Seq_LNCAP_Human2.13651328
25DCP1A_22483619_ChIP-Seq_HELA_Human2.12401577
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10882646
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08388091
28* GABP_19822575_ChIP-Seq_HepG2_Human2.01584903
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91683536
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.90102828
31FOXP3_21729870_ChIP-Seq_TREG_Human1.88854133
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85661890
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85384588
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84060467
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83618683
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82202062
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80985927
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80650435
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76361357
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75414965
41TTF2_22483619_ChIP-Seq_HELA_Human1.67288689
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64942017
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.58000653
44ELK1_19687146_ChIP-ChIP_HELA_Human1.57503452
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56980755
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.55922227
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55479535
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53289719
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50076063
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49099630
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44783409
52KDM5A_27292631_Chip-Seq_BREAST_Human1.40655030
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36254742
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36254742
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36254742
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32420356
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30107717
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29549472
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28861618
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26812487
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26800192
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26704075
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26352518
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26317648
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25118296
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23694198
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22460451
68NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20989501
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20332805
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18667965
71EZH2_22144423_ChIP-Seq_EOC_Human1.18440548
72MYC_18940864_ChIP-ChIP_HL60_Human1.18306948
73CIITA_25753668_ChIP-Seq_RAJI_Human1.17202438
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14772467
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.14239682
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13138856
77* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12057363
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10375582
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09737105
80TFEB_21752829_ChIP-Seq_HELA_Human1.09373373
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06973448
82SPI1_23547873_ChIP-Seq_NB4_Human1.03087135
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.02514649
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01525958
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00876171
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00464068
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00459239
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99716946
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99535213
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97800263
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96686948
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95064775
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94987153
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93426684
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92277661
96TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86061810
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.84640904
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83569906
99MYC_22102868_ChIP-Seq_BL_Human0.83360100
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82174718
101ELF5_23300383_ChIP-Seq_T47D_Human0.81762952
102* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81088586
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80858163
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.80713918
105TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80607169
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79417315
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78592524
108PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78474358
109IRF8_21731497_ChIP-ChIP_J774_Mouse0.77955541
110TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.76293281
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75246821
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75220820
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75137710
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.74127701
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73752605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.65430247
2MP0004957_abnormal_blastocyst_morpholog4.26335657
3MP0010094_abnormal_chromosome_stability4.12080311
4MP0003077_abnormal_cell_cycle3.67042390
5MP0003718_maternal_effect3.64656116
6MP0003111_abnormal_nucleus_morphology3.61059005
7MP0008058_abnormal_DNA_repair2.80575526
8MP0008932_abnormal_embryonic_tissue2.76258405
9MP0003806_abnormal_nucleotide_metabolis2.75761925
10MP0008877_abnormal_DNA_methylation2.52568339
11MP0008057_abnormal_DNA_replication2.50810829
12MP0003646_muscle_fatigue2.37822553
13MP0003186_abnormal_redox_activity2.29211971
14MP0005499_abnormal_olfactory_system2.27477804
15MP0005394_taste/olfaction_phenotype2.27477804
16MP0008007_abnormal_cellular_replicative2.27358828
17MP0005451_abnormal_body_composition2.22242380
18MP0010030_abnormal_orbit_morphology2.04228146
19MP0005058_abnormal_lysosome_morphology2.03689627
20MP0001730_embryonic_growth_arrest2.01944578
21MP0003123_paternal_imprinting1.90154773
22MP0002139_abnormal_hepatobiliary_system1.87455735
23MP0010234_abnormal_vibrissa_follicle1.74760587
24MP0000350_abnormal_cell_proliferation1.71850975
25MP0000490_abnormal_crypts_of1.69358150
26MP0003941_abnormal_skin_development1.66654089
27MP0006035_abnormal_mitochondrial_morpho1.64561871
28MP0002102_abnormal_ear_morphology1.64444979
29MP0003786_premature_aging1.58408468
30MP0003315_abnormal_perineum_morphology1.55427624
31MP0005075_abnormal_melanosome_morpholog1.51856342
32MP0005501_abnormal_skin_physiology1.50267451
33MP0001119_abnormal_female_reproductive1.47486177
34MP0009333_abnormal_splenocyte_physiolog1.46369975
35MP0002396_abnormal_hematopoietic_system1.43929509
36MP0002019_abnormal_tumor_incidence1.42758015
37MP0005360_urolithiasis1.42215394
38MP0001697_abnormal_embryo_size1.38623362
39MP0000372_irregular_coat_pigmentation1.38323739
40MP0006292_abnormal_olfactory_placode1.36708710
41* MP0002210_abnormal_sex_determination1.34032875
42MP0003763_abnormal_thymus_physiology1.33937155
43MP0002796_impaired_skin_barrier1.32518774
44MP0005395_other_phenotype1.31073490
45MP0001929_abnormal_gametogenesis1.29954341
46MP0005408_hypopigmentation1.28230576
47MP0001881_abnormal_mammary_gland1.26966230
48MP0005380_embryogenesis_phenotype1.25270554
49MP0001672_abnormal_embryogenesis/_devel1.25270554
50MP0002085_abnormal_embryonic_tissue1.23083438
51MP0000313_abnormal_cell_death1.22468452
52* MP0000653_abnormal_sex_gland1.22408812
53MP0002090_abnormal_vision1.19971984
54MP0005410_abnormal_fertilization1.18920768
55MP0002138_abnormal_hepatobiliary_system1.17514233
56MP0010352_gastrointestinal_tract_polyps1.16602228
57MP0002080_prenatal_lethality1.16475688
58MP0001764_abnormal_homeostasis1.16137215
59MP0001293_anophthalmia1.14256451
60MP0003183_abnormal_peptide_metabolism1.12523359
61* MP0001145_abnormal_male_reproductive1.10470652
62* MP0003699_abnormal_female_reproductive1.06874130
63MP0008260_abnormal_autophagy1.05606720
64MP0003984_embryonic_growth_retardation1.05527739
65MP0003191_abnormal_cellular_cholesterol1.05271655
66MP0010307_abnormal_tumor_latency1.03206382
67MP0002148_abnormal_hypersensitivity_rea1.02452316
68MP0002088_abnormal_embryonic_growth/wei0.99868862
69MP0003890_abnormal_embryonic-extraembry0.98940861
70MP0002084_abnormal_developmental_patter0.95561264
71MP0005389_reproductive_system_phenotype0.93464960
72MP0005319_abnormal_enzyme/_coenzyme0.93421055
73MP0003436_decreased_susceptibility_to0.93108373
74MP0002653_abnormal_ependyma_morphology0.92680529
75MP0002249_abnormal_larynx_morphology0.92165488
76* MP0006036_abnormal_mitochondrial_physio0.91381201
77MP0003950_abnormal_plasma_membrane0.91134933
78MP0001919_abnormal_reproductive_system0.90480839
79MP0009840_abnormal_foam_cell0.89366666
80MP0000358_abnormal_cell_content/0.88591077
81* MP0000689_abnormal_spleen_morphology0.88217296
82MP0001853_heart_inflammation0.87917557
83MP0005023_abnormal_wound_healing0.87576895
84MP0004233_abnormal_muscle_weight0.87115907
85MP0004782_abnormal_surfactant_physiolog0.86899411
86MP0002405_respiratory_system_inflammati0.85885220
87MP0002132_abnormal_respiratory_system0.82638204
88MP0002722_abnormal_immune_system0.82155812
89MP0003221_abnormal_cardiomyocyte_apopto0.82014778
90MP0000858_altered_metastatic_potential0.81659549
91* MP0002398_abnormal_bone_marrow0.81649182
92MP0002086_abnormal_extraembryonic_tissu0.80571860
93MP0003937_abnormal_limbs/digits/tail_de0.77647226
94MP0005266_abnormal_metabolism0.76304528
95MP0001835_abnormal_antigen_presentation0.75243308
96MP0000015_abnormal_ear_pigmentation0.75118882
97MP0000465_gastrointestinal_hemorrhage0.74015586
98* MP0002429_abnormal_blood_cell0.72919980
99MP0009785_altered_susceptibility_to0.72136901
100MP0005647_abnormal_sex_gland0.71566536
101MP0001915_intracranial_hemorrhage0.71009047
102MP0001727_abnormal_embryo_implantation0.70932486
103MP0004133_heterotaxia0.70570411
104MP0000343_altered_response_to0.70007674
105MP0005000_abnormal_immune_tolerance0.69714733
106* MP0005384_cellular_phenotype0.68416945
107* MP0005621_abnormal_cell_physiology0.68334118
108MP0002452_abnormal_antigen_presenting0.67815348
109MP0005397_hematopoietic_system_phenotyp0.67740370
110MP0001545_abnormal_hematopoietic_system0.67740370
111MP0002234_abnormal_pharynx_morphology0.67311343
112MP0002254_reproductive_system_inflammat0.67187409
113MP0002160_abnormal_reproductive_system0.66646465
114MP0003121_genomic_imprinting0.65645115
115MP0003698_abnormal_male_reproductive0.65245620
116* MP0000716_abnormal_immune_system0.64792328
117MP0008873_increased_physiological_sensi0.63990524
118MP0006082_CNS_inflammation0.63903401
119MP0002161_abnormal_fertility/fecundity0.63330952
120MP0009697_abnormal_copulation0.63261938
121MP0008789_abnormal_olfactory_epithelium0.61667403
122* MP0002420_abnormal_adaptive_immunity0.60958964
123MP0005025_abnormal_response_to0.60611104
124MP0000685_abnormal_immune_system0.60353429
125* MP0001819_abnormal_immune_cell0.60351150
126MP0002723_abnormal_immune_serum0.59555417
127MP0003656_abnormal_erythrocyte_physiolo0.59113934
128MP0002877_abnormal_melanocyte_morpholog0.58951373
129* MP0000703_abnormal_thymus_morphology0.58767773
130MP0002111_abnormal_tail_morphology0.58227471
131MP0009379_abnormal_foot_pigmentation0.57311875
132MP0000762_abnormal_tongue_morphology0.53732792
133MP0009672_abnormal_birth_weight0.52510500
134MP0000627_abnormal_mammary_gland0.50837257
135MP0002095_abnormal_skin_pigmentation0.50407204
136MP0001529_abnormal_vocalization0.48577417
137MP0005464_abnormal_platelet_physiology0.47978347
138MP0008469_abnormal_protein_level0.47743039
139MP0001986_abnormal_taste_sensitivity0.47339978

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.83550972
2Cholecystitis (HP:0001082)4.76680777
3Abnormal gallbladder physiology (HP:0012438)4.76680777
4Breast hypoplasia (HP:0003187)4.37832812
5Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.88479163
6Oral leukoplakia (HP:0002745)3.82858456
7Microvesicular hepatic steatosis (HP:0001414)3.79594610
8Premature ovarian failure (HP:0008209)3.44752750
9Carpal bone hypoplasia (HP:0001498)3.41328873
10Aplastic anemia (HP:0001915)3.28146334
11Cerebral hypomyelination (HP:0006808)3.22903242
12Rough bone trabeculation (HP:0100670)3.20377672
13Patellar aplasia (HP:0006443)3.16258050
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09552857
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09552857
16Hypokinesia (HP:0002375)3.08429045
17Loss of speech (HP:0002371)3.07983046
18Abnormality of the anterior horn cell (HP:0006802)3.07655291
19Degeneration of anterior horn cells (HP:0002398)3.07655291
20Chromsome breakage (HP:0040012)3.06607612
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.04575469
22Abnormal protein N-linked glycosylation (HP:0012347)3.04575469
23Abnormal protein glycosylation (HP:0012346)3.04575469
24Abnormal glycosylation (HP:0012345)3.04575469
25Increased serum pyruvate (HP:0003542)2.98533712
26Abnormality of glycolysis (HP:0004366)2.98533712
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93519175
28Abnormality of alanine metabolism (HP:0010916)2.93519175
29Hyperalaninemia (HP:0003348)2.93519175
30Aplasia/Hypoplasia of the patella (HP:0006498)2.92997590
31Secondary amenorrhea (HP:0000869)2.88639533
32Abnormality of the preputium (HP:0100587)2.84395305
33Abnormality of cells of the erythroid lineage (HP:0012130)2.81760014
34Nausea (HP:0002018)2.76732725
35Supernumerary spleens (HP:0009799)2.75941756
36Acute necrotizing encephalopathy (HP:0006965)2.72349548
37Male infertility (HP:0003251)2.72348533
38Muscle fiber atrophy (HP:0100295)2.70758363
39Reticulocytopenia (HP:0001896)2.70302607
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69701383
41Type 2 muscle fiber atrophy (HP:0003554)2.69197081
42Reduced antithrombin III activity (HP:0001976)2.65925349
43Posterior subcapsular cataract (HP:0007787)2.62289824
44Abnormal number of erythroid precursors (HP:0012131)2.59982486
45Meckel diverticulum (HP:0002245)2.56112916
46Abnormality of chromosome stability (HP:0003220)2.54801748
47Agnosia (HP:0010524)2.53099599
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52429078
49Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51816827
50Multiple enchondromatosis (HP:0005701)2.51602955
51Abnormal lung lobation (HP:0002101)2.50375753
52Irregular epiphyses (HP:0010582)2.49228611
53Hepatocellular necrosis (HP:0001404)2.48048039
54Abnormal trabecular bone morphology (HP:0100671)2.47858109
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.47448383
56Acute encephalopathy (HP:0006846)2.46079971
57Microretrognathia (HP:0000308)2.44566062
58Hepatic necrosis (HP:0002605)2.44177258
59Progressive muscle weakness (HP:0003323)2.44139279
60Abnormal mitochondria in muscle tissue (HP:0008316)2.43859497
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43345847
62Cerebral edema (HP:0002181)2.41934392
63Abnormality of the ileum (HP:0001549)2.38926752
64Increased intramyocellular lipid droplets (HP:0012240)2.37704931
65Adrenal hypoplasia (HP:0000835)2.37280918
66Abnormality of glycolipid metabolism (HP:0010969)2.36852759
67Abnormality of liposaccharide metabolism (HP:0010968)2.36852759
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.36852759
69Bone marrow hypocellularity (HP:0005528)2.35364498
70Increased CSF lactate (HP:0002490)2.34579380
71Increased serum lactate (HP:0002151)2.33346603
72Renal Fanconi syndrome (HP:0001994)2.31729931
73Exercise intolerance (HP:0003546)2.31418615
74Hypergonadotropic hypogonadism (HP:0000815)2.29872030
75Pulmonary fibrosis (HP:0002206)2.29178000
76Duodenal stenosis (HP:0100867)2.28304167
77Small intestinal stenosis (HP:0012848)2.28304167
78Mitochondrial inheritance (HP:0001427)2.27988811
79Abnormal spermatogenesis (HP:0008669)2.25149785
80Muscle stiffness (HP:0003552)2.24530819
81Sloping forehead (HP:0000340)2.24399744
82Abnormality of abdominal situs (HP:0011620)2.22284163
83Abdominal situs inversus (HP:0003363)2.22284163
84Short tibia (HP:0005736)2.21613944
85Premature graying of hair (HP:0002216)2.21283130
86Myelodysplasia (HP:0002863)2.20117200
87Median cleft lip (HP:0000161)2.19259033
88Hypophosphatemic rickets (HP:0004912)2.17280577
89Generalized aminoaciduria (HP:0002909)2.16616583
90Type I transferrin isoform profile (HP:0003642)2.15596837
91Absent radius (HP:0003974)2.12566259
92Flat capital femoral epiphysis (HP:0003370)2.11035042
93Abnormality of aromatic amino acid family metabolism (HP:0004338)2.08227578
94Stenosis of the external auditory canal (HP:0000402)2.08199682
95Diminished motivation (HP:0000745)2.07004299
96Increased muscle lipid content (HP:0009058)2.05318109
97Selective tooth agenesis (HP:0001592)2.05304430
98Microglossia (HP:0000171)2.05245899
99Septo-optic dysplasia (HP:0100842)2.04987146
100Congenital ichthyosiform erythroderma (HP:0007431)2.04675961
101Aplasia/Hypoplasia of the breasts (HP:0010311)2.04110000
102Abnormality of the labia minora (HP:0012880)2.02167812
103Breast aplasia (HP:0100783)2.00716977
104Respiratory difficulties (HP:0002880)2.00127986
105Gonadotropin excess (HP:0000837)2.00026483
106Vacuolated lymphocytes (HP:0001922)1.98661849
107Colon cancer (HP:0003003)1.98572807
108Trismus (HP:0000211)1.97565807
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97120441
110Aplasia/Hypoplasia of the fovea (HP:0008060)1.96987209
111Hypoplasia of the fovea (HP:0007750)1.96987209
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94715240
113Aplasia involving forearm bones (HP:0009822)1.94349334
114Absent forearm bone (HP:0003953)1.94349334
115Cellular immunodeficiency (HP:0005374)1.93578707
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92902122
117Macrocytic anemia (HP:0001972)1.92437153
118CNS hypomyelination (HP:0003429)1.92090253
119Absent thumb (HP:0009777)1.92057990
120Horseshoe kidney (HP:0000085)1.91995354
121Impulsivity (HP:0100710)1.91449644
122Pancytopenia (HP:0001876)1.91115211
123Abnormality of the duodenum (HP:0002246)1.90134511
124Progressive neurologic deterioration (HP:0002344)1.89410788
125Ragged-red muscle fibers (HP:0003200)1.88992281
126Hepatosplenomegaly (HP:0001433)1.88563046
127Absent septum pellucidum (HP:0001331)1.87767747
128Subcapsular cataract (HP:0000523)1.87722776
129Exertional dyspnea (HP:0002875)1.87366523
130Poor head control (HP:0002421)1.85268884
131Lipid accumulation in hepatocytes (HP:0006561)1.84522870
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84318215
133Dicarboxylic aciduria (HP:0003215)1.84318215
134Medulloblastoma (HP:0002885)1.83660188
135Prolonged neonatal jaundice (HP:0006579)1.83039713
136Abnormality of the septum pellucidum (HP:0007375)1.82992418
137Lactic acidosis (HP:0003128)1.82843771
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82636577
139Increased hepatocellular lipid droplets (HP:0006565)1.82074987
140Progressive macrocephaly (HP:0004481)1.81818083
141Postnatal microcephaly (HP:0005484)1.81529379
142Sparse eyelashes (HP:0000653)1.80918383
143Tongue fasciculations (HP:0001308)1.80537004
144Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79215553
145IgM deficiency (HP:0002850)1.78107798
146Triphalangeal thumb (HP:0001199)1.75287420
147Rhabdomyosarcoma (HP:0002859)1.74338533
148Thrombocytosis (HP:0001894)1.73405556
149Respiratory failure (HP:0002878)1.73272479
1503-Methylglutaconic aciduria (HP:0003535)1.72409097
151Cleft eyelid (HP:0000625)1.71878859
152Megaloblastic anemia (HP:0001889)1.70967754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.26874126
2EIF2AK13.55875208
3VRK23.31443905
4PLK43.25678066
5WEE13.10255479
6CDC72.90214817
7TTK2.71658098
8TESK22.42695364
9EIF2AK32.27728881
10BRAF2.19381551
11STK162.14775864
12VRK12.05194204
13ACVR1B2.03066690
14BRSK21.96814834
15MAPKAPK31.95473662
16MAP3K91.91677395
17STK101.82520648
18PLK11.82254268
19RPS6KB21.82179116
20NEK21.77824769
21PDK21.74020790
22ERBB41.71260786
23MUSK1.68945670
24MKNK11.67380600
25SRPK11.66968014
26TRIM281.65841744
27MAP3K61.62925925
28STK38L1.53080563
29NME21.48474612
30PLK31.43295801
31NEK11.43062515
32AURKB1.41865863
33TESK11.40139449
34EEF2K1.38225210
35MAP3K81.35449646
36NUAK11.34961356
37CDK71.33374019
38MAP3K111.30271482
39CHEK21.29797744
40AURKA1.26932453
41PBK1.23640139
42ARAF1.18844164
43MAPKAPK51.14388349
44BCKDK1.12928343
45MOS1.12312558
46TSSK61.10679936
47NEK61.10351433
48ABL21.09671610
49PIM21.08866212
50CDK91.07077397
51EPHA21.07042295
52LIMK11.05607419
53BRSK11.04230394
54MST41.02255636
55DYRK21.02146802
56ATR0.99544332
57KDR0.99484800
58CDK80.99176642
59NME10.98364942
60DAPK10.97164537
61RAF10.94288919
62EIF2AK20.87870901
63RPS6KA40.87047885
64TLK10.85849246
65MELK0.82392403
66TRPM70.81981733
67DYRK30.81251472
68LATS20.80607130
69NEK90.80106721
70MAP4K10.79733953
71IRAK40.76909245
72PIM10.75334036
73TGFBR10.72600036
74PAK10.71563030
75STK40.70929298
76CSNK1G10.70466255
77ADRBK20.70208706
78IRAK30.65860631
79CSNK1G20.63788339
80MARK30.63422287
81PASK0.63223365
82CHEK10.62647159
83ZAK0.62411733
84BLK0.62394783
85PAK40.62244209
86CSNK1A1L0.61283584
87BMPR20.61195147
88STK30.60968014
89TAOK30.57132131
90ALK0.56864160
91CSNK2A10.55666259
92KSR20.55625163
93CDK40.54832531
94DMPK0.54163978
95SCYL20.51949906
96CCNB10.50451730
97TAOK20.48616528
98LRRK20.48047611
99MAP3K130.45164018
100ATM0.44824635
101STK240.43806083
102CSNK1G30.43343337
103PRKCI0.43264483
104FLT30.41753657
105TYK20.41427914
106MAP4K20.40632080
107TAOK10.40564770
108CSNK2A20.40399103
109RPS6KA50.40329647
110TAF10.40075254
111MET0.39625443
112CDK20.39297051
113CDK140.38015852
114CDK190.37532078
115CDK10.36731592
116BTK0.36603884
117MAP3K50.35383048
118CDK11A0.35111665
119ILK0.34509743
120MAP2K70.34233688
121BMPR1B0.34208221
122MAP3K120.34191566
123JAK30.33514009
124NLK0.33398065
125MAP3K30.33295329
126AKT20.30219377
127PTK20.28583424
128CSNK1E0.27700403
129TNIK0.27530320
130CDK180.27477174

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19629552
2Proteasome_Homo sapiens_hsa030503.85270315
3Mismatch repair_Homo sapiens_hsa034303.49700384
4RNA polymerase_Homo sapiens_hsa030203.46847932
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32232677
6Ribosome_Homo sapiens_hsa030102.93289540
7Homologous recombination_Homo sapiens_hsa034402.82665179
8Base excision repair_Homo sapiens_hsa034102.80248216
9RNA transport_Homo sapiens_hsa030132.63056131
10Cell cycle_Homo sapiens_hsa041102.55570241
11Spliceosome_Homo sapiens_hsa030402.49858708
12Nucleotide excision repair_Homo sapiens_hsa034202.44539311
13Pyrimidine metabolism_Homo sapiens_hsa002402.37237877
14Basal transcription factors_Homo sapiens_hsa030222.35408377
15RNA degradation_Homo sapiens_hsa030182.30516571
16One carbon pool by folate_Homo sapiens_hsa006702.19134318
17Non-homologous end-joining_Homo sapiens_hsa034502.04600592
18Protein export_Homo sapiens_hsa030601.98774492
19Fanconi anemia pathway_Homo sapiens_hsa034601.98571015
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78192074
21Folate biosynthesis_Homo sapiens_hsa007901.60753248
22p53 signaling pathway_Homo sapiens_hsa041151.43582880
23Purine metabolism_Homo sapiens_hsa002301.33877322
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25347686
25Vitamin B6 metabolism_Homo sapiens_hsa007501.23319222
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.19207503
27mRNA surveillance pathway_Homo sapiens_hsa030151.14226718
28Glutathione metabolism_Homo sapiens_hsa004801.07398066
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01420403
30Epstein-Barr virus infection_Homo sapiens_hsa051690.98773090
31Sulfur metabolism_Homo sapiens_hsa009200.97958446
32Sulfur relay system_Homo sapiens_hsa041220.94465242
33Other glycan degradation_Homo sapiens_hsa005110.94206452
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93525569
35Huntingtons disease_Homo sapiens_hsa050160.93273923
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90053566
37Oxidative phosphorylation_Homo sapiens_hsa001900.89212568
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88791120
39Biosynthesis of amino acids_Homo sapiens_hsa012300.88179791
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87122394
41Parkinsons disease_Homo sapiens_hsa050120.86610552
42Arachidonic acid metabolism_Homo sapiens_hsa005900.85600836
43Linoleic acid metabolism_Homo sapiens_hsa005910.84438250
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80237564
45Pentose phosphate pathway_Homo sapiens_hsa000300.80220557
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.76086725
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.74390503
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74344173
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74168462
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74156414
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70379316
52Asthma_Homo sapiens_hsa053100.69806627
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66302727
54Legionellosis_Homo sapiens_hsa051340.66245776
55Herpes simplex infection_Homo sapiens_hsa051680.65098407
56Selenocompound metabolism_Homo sapiens_hsa004500.64446319
57Shigellosis_Homo sapiens_hsa051310.62279750
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61999993
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61836816
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61151835
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59183661
62Lysosome_Homo sapiens_hsa041420.57980603
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57697703
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.56636257
65Oocyte meiosis_Homo sapiens_hsa041140.56322351
66Carbon metabolism_Homo sapiens_hsa012000.55687227
67Arginine and proline metabolism_Homo sapiens_hsa003300.53388867
68Thyroid cancer_Homo sapiens_hsa052160.52426693
69Viral carcinogenesis_Homo sapiens_hsa052030.51088991
70Antigen processing and presentation_Homo sapiens_hsa046120.50398596
71Metabolic pathways_Homo sapiens_hsa011000.50233314
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46913858
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46239831
74TGF-beta signaling pathway_Homo sapiens_hsa043500.45649098
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45280980
76Ether lipid metabolism_Homo sapiens_hsa005650.44214691
77Galactose metabolism_Homo sapiens_hsa000520.43840631
78Pyruvate metabolism_Homo sapiens_hsa006200.42628739
79Allograft rejection_Homo sapiens_hsa053300.42325720
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41878304
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40713261
82Rheumatoid arthritis_Homo sapiens_hsa053230.40398130
83Apoptosis_Homo sapiens_hsa042100.37837707
84HTLV-I infection_Homo sapiens_hsa051660.37170090
85Cardiac muscle contraction_Homo sapiens_hsa042600.36920795
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36903884
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36372707
88Vibrio cholerae infection_Homo sapiens_hsa051100.36162927
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36126351
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35096460
91Autoimmune thyroid disease_Homo sapiens_hsa053200.33542457
92Systemic lupus erythematosus_Homo sapiens_hsa053220.33227452
93Steroid biosynthesis_Homo sapiens_hsa001000.30225767
94Caffeine metabolism_Homo sapiens_hsa002320.28696137
95Fructose and mannose metabolism_Homo sapiens_hsa000510.27864828
96Regulation of autophagy_Homo sapiens_hsa041400.26934322
97Peroxisome_Homo sapiens_hsa041460.26887409
98Alzheimers disease_Homo sapiens_hsa050100.26764046
99Sphingolipid metabolism_Homo sapiens_hsa006000.26334699
100Histidine metabolism_Homo sapiens_hsa003400.22201736
101MicroRNAs in cancer_Homo sapiens_hsa052060.21895087
102Collecting duct acid secretion_Homo sapiens_hsa049660.21155935
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21147408
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.21084181
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20681611
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20440925
107Arginine biosynthesis_Homo sapiens_hsa002200.19651344
108Type I diabetes mellitus_Homo sapiens_hsa049400.18478152
109Bladder cancer_Homo sapiens_hsa052190.18431518
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18035263
111Fatty acid metabolism_Homo sapiens_hsa012120.17960078
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17926764
113Propanoate metabolism_Homo sapiens_hsa006400.17665276
114Graft-versus-host disease_Homo sapiens_hsa053320.17073992
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14939198
116N-Glycan biosynthesis_Homo sapiens_hsa005100.14510769
117Ovarian steroidogenesis_Homo sapiens_hsa049130.14459414
118Primary immunodeficiency_Homo sapiens_hsa053400.13289497
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13203983
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.12702486
121Fatty acid elongation_Homo sapiens_hsa000620.12585833
122beta-Alanine metabolism_Homo sapiens_hsa004100.12494734
123Small cell lung cancer_Homo sapiens_hsa052220.12366723
124Phagosome_Homo sapiens_hsa041450.12101215

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