PARD6G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.61496400
2hemidesmosome assembly (GO:0031581)5.37680121
3behavioral response to nicotine (GO:0035095)5.20904537
4negative regulation of keratinocyte proliferation (GO:0010839)3.86791586
5planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76991673
6viral transcription (GO:0019083)3.72573851
7outer ear morphogenesis (GO:0042473)3.64030862
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.58969825
9paraxial mesoderm development (GO:0048339)3.57609385
10establishment of tissue polarity (GO:0007164)3.56851001
11establishment of planar polarity (GO:0001736)3.56851001
12translational termination (GO:0006415)3.56261808
13lateral sprouting from an epithelium (GO:0060601)3.44052320
14epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.33690540
15regulation of mesoderm development (GO:2000380)3.33346262
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30959952
17somite development (GO:0061053)3.26999913
18regulation of transforming growth factor beta2 production (GO:0032909)3.24946528
19mesenchyme morphogenesis (GO:0072132)3.24203338
20maturation of SSU-rRNA (GO:0030490)3.22245561
21regulation of hippo signaling (GO:0035330)3.18778263
22molting cycle (GO:0042303)3.17345920
23hair cycle (GO:0042633)3.17345920
24fucose catabolic process (GO:0019317)3.16104961
25L-fucose metabolic process (GO:0042354)3.16104961
26L-fucose catabolic process (GO:0042355)3.16104961
27regulation of keratinocyte proliferation (GO:0010837)3.12910753
28keratinization (GO:0031424)3.11431215
29mesenchymal cell differentiation involved in kidney development (GO:0072161)3.09142343
30mesenchymal cell differentiation involved in renal system development (GO:2001012)3.09142343
31regulation of gene silencing by RNA (GO:0060966)3.08370360
32regulation of posttranscriptional gene silencing (GO:0060147)3.08370360
33regulation of gene silencing by miRNA (GO:0060964)3.08370360
34negative regulation of epidermis development (GO:0045683)3.02244836
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01957593
36keratinocyte differentiation (GO:0030216)2.98357942
37eyelid development in camera-type eye (GO:0061029)2.98337836
38DNA topological change (GO:0006265)2.96360295
39cardiac right ventricle morphogenesis (GO:0003215)2.95523605
40metanephric mesenchyme development (GO:0072075)2.95212446
41endocardial cushion morphogenesis (GO:0003203)2.95202738
42pattern specification involved in kidney development (GO:0061004)2.94751648
43translational elongation (GO:0006414)2.94279850
44establishment of skin barrier (GO:0061436)2.93503852
45piRNA metabolic process (GO:0034587)2.91937922
46regulation of water loss via skin (GO:0033561)2.91011291
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90042336
48atrioventricular valve morphogenesis (GO:0003181)2.89439124
49negative regulation of cell fate specification (GO:0009996)2.89030335
50pyrimidine nucleobase catabolic process (GO:0006208)2.88734173
51ribosomal small subunit biogenesis (GO:0042274)2.87525026
52notochord development (GO:0030903)2.86640146
53mesenchymal cell proliferation (GO:0010463)2.85833954
54cell migration involved in heart development (GO:0060973)2.85829220
55cell proliferation in forebrain (GO:0021846)2.83902134
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82951056
57protein targeting to ER (GO:0045047)2.82127631
58cell proliferation involved in metanephros development (GO:0072203)2.81822705
59kidney morphogenesis (GO:0060993)2.81004503
60artery development (GO:0060840)2.80814022
61hippo signaling (GO:0035329)2.80655055
62cotranslational protein targeting to membrane (GO:0006613)2.80278229
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79365614
64proximal/distal pattern formation (GO:0009954)2.78973490
65dorsal/ventral axis specification (GO:0009950)2.77868425
66embryonic skeletal joint morphogenesis (GO:0060272)2.77125836
67cellular protein complex disassembly (GO:0043624)2.76464900
68embryonic cranial skeleton morphogenesis (GO:0048701)2.75528846
69regulation of meiosis I (GO:0060631)2.75230234
70viral life cycle (GO:0019058)2.74503214
71nephron tubule morphogenesis (GO:0072078)2.74237908
72nephron epithelium morphogenesis (GO:0072088)2.74237908
73odontogenesis (GO:0042476)2.72905805
74kidney mesenchyme development (GO:0072074)2.72123711
75negative regulation of embryonic development (GO:0045992)2.71537352
76keratinocyte proliferation (GO:0043616)2.70451516
77neuron projection extension involved in neuron projection guidance (GO:1902284)2.69315692
78axon extension involved in axon guidance (GO:0048846)2.69315692
79negative regulation of axon extension involved in axon guidance (GO:0048843)2.68998080
80cell surface receptor signaling pathway involved in heart development (GO:0061311)2.68860529
81regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.68784254
82regulation of heart morphogenesis (GO:2000826)2.68382228
83establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67051026
84regulation of somitogenesis (GO:0014807)2.66885601
85cochlea morphogenesis (GO:0090103)2.66144823
86heart valve morphogenesis (GO:0003179)2.65943559
87middle ear morphogenesis (GO:0042474)2.65077669
88magnesium ion transport (GO:0015693)2.64069583
89translational initiation (GO:0006413)2.63032625
90regulation of mesenchymal cell apoptotic process (GO:2001053)2.62842759
91regulation of action potential (GO:0098900)2.62698877
92protein complex disassembly (GO:0043241)2.62380609
93retinal cone cell development (GO:0046549)2.61993851
94ribosomal large subunit biogenesis (GO:0042273)2.61637776
95regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61101605
96collecting duct development (GO:0072044)2.60740350
97odontogenesis of dentin-containing tooth (GO:0042475)2.60648940
98regulation of cardioblast proliferation (GO:0003264)2.60403589
99regulation of secondary heart field cardioblast proliferation (GO:0003266)2.60403589
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58576372
101mesenchymal to epithelial transition (GO:0060231)2.57428886
102neuron fate determination (GO:0048664)2.56269880
103neuronal stem cell maintenance (GO:0097150)2.56186192
104nonmotile primary cilium assembly (GO:0035058)2.54974490
105polarized epithelial cell differentiation (GO:0030859)2.54889354
106protein localization to endoplasmic reticulum (GO:0070972)2.53373578
107regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.52653310
108non-canonical Wnt signaling pathway (GO:0035567)2.51391767
109negative regulation of catenin import into nucleus (GO:0035414)2.51266754
110positive regulation of gastrulation (GO:2000543)2.49327486
111response to pheromone (GO:0019236)2.48977748
112cornea development in camera-type eye (GO:0061303)2.48858170
113establishment of protein localization to mitochondrial membrane (GO:0090151)2.47949047
114negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.47885754
115cell differentiation involved in metanephros development (GO:0072202)2.47315571
116cell proliferation involved in kidney development (GO:0072111)2.47308394
117negative regulation of oligodendrocyte differentiation (GO:0048715)2.46801103
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.46450812
119cranial nerve morphogenesis (GO:0021602)2.46423246
120somite rostral/caudal axis specification (GO:0032525)2.46110317
121segment specification (GO:0007379)2.46064692
122urogenital system development (GO:0001655)2.45933170
123cardiac epithelial to mesenchymal transition (GO:0060317)2.45344834
124regulation of hair follicle development (GO:0051797)2.45076607
125cell-substrate junction assembly (GO:0007044)2.44661970
126respiratory tube development (GO:0030323)2.43770653
127hindlimb morphogenesis (GO:0035137)2.43736859
128glomerulus development (GO:0032835)2.43506982
129macromolecular complex disassembly (GO:0032984)2.43326919
130lung-associated mesenchyme development (GO:0060484)2.43160662
131epidermis development (GO:0008544)2.43124348
132embryonic hindlimb morphogenesis (GO:0035116)2.42974034
133behavioral response to ethanol (GO:0048149)2.42407358
134head development (GO:0060322)2.42294128
135epithelial cilium movement (GO:0003351)2.41642548
136mesenchyme development (GO:0060485)2.41623647
137water-soluble vitamin biosynthetic process (GO:0042364)2.41396000
138reflex (GO:0060004)2.40425367
139positive regulation of action potential (GO:0045760)2.39972148
140endoderm formation (GO:0001706)2.38642579
141negative regulation of glial cell differentiation (GO:0045686)2.35970080
142negative regulation of translation, ncRNA-mediated (GO:0040033)2.35410558
143regulation of translation, ncRNA-mediated (GO:0045974)2.35410558
144negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35410558
145retinal ganglion cell axon guidance (GO:0031290)2.33759658
146calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32303102
147hindbrain development (GO:0030902)2.31558322
148limb bud formation (GO:0060174)2.31359314
149negative regulation of transcription regulatory region DNA binding (GO:2000678)2.30037543
150DNA double-strand break processing (GO:0000729)2.29254852
151regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.28052109
152regulation of mitotic spindle checkpoint (GO:1903504)2.28052109
153negative regulation of telomere maintenance (GO:0032205)2.26512966
154neural tube formation (GO:0001841)2.26130229
155spinal cord development (GO:0021510)2.22926284
156protein polyglutamylation (GO:0018095)2.22680990
157DNA methylation involved in gamete generation (GO:0043046)2.22648941
158cilium morphogenesis (GO:0060271)2.21674153
159kynurenine metabolic process (GO:0070189)2.20493938
160ectoderm development (GO:0007398)2.20487199
161embryonic pattern specification (GO:0009880)2.19391579
162mitochondrial respiratory chain complex I assembly (GO:0032981)2.19058725
163NADH dehydrogenase complex assembly (GO:0010257)2.19058725
164mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.19058725
165negative regulation of DNA-dependent DNA replication (GO:2000104)2.18604396
166ubiquinone metabolic process (GO:0006743)2.18478869
167nucleobase catabolic process (GO:0046113)2.18438129
168synapsis (GO:0007129)2.17433402
169establishment of monopolar cell polarity (GO:0061162)2.16901428
170establishment or maintenance of monopolar cell polarity (GO:0061339)2.16901428
171RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.14767568
172tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.14767568
173platelet dense granule organization (GO:0060155)2.14765639
174negative regulation of astrocyte differentiation (GO:0048712)2.13855420
175renal tubule morphogenesis (GO:0061333)2.12882202
176keratinocyte development (GO:0003334)2.12857912
177smoothened signaling pathway (GO:0007224)2.12108941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.47175394
2EZH2_22144423_ChIP-Seq_EOC_Human4.14086674
3ZNF274_21170338_ChIP-Seq_K562_Hela3.65900071
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.28577731
5* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.25960408
6E2F7_22180533_ChIP-Seq_HELA_Human3.25572073
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.80290911
8VDR_22108803_ChIP-Seq_LS180_Human2.69940619
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.64529070
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.53665676
11TP53_20018659_ChIP-ChIP_R1E_Mouse2.50377524
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29854280
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.28630502
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24770808
15GBX2_23144817_ChIP-Seq_PC3_Human2.22725761
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.19590385
17IGF1R_20145208_ChIP-Seq_DFB_Human2.12710181
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12120955
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07887448
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.06704588
21FUS_26573619_Chip-Seq_HEK293_Human2.03864590
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03231812
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02269348
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.01175148
25TP63_17297297_ChIP-ChIP_HaCaT_Human10.6775254
26EWS_26573619_Chip-Seq_HEK293_Human1.99541176
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97302779
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92667738
29MYC_18940864_ChIP-ChIP_HL60_Human1.88276335
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.88229738
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.85577245
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.83284902
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80072909
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78930799
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77951836
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.77654024
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.77441271
38KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.76857945
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72887922
40AR_21909140_ChIP-Seq_LNCAP_Human1.71657469
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71369473
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69614009
43IRF1_19129219_ChIP-ChIP_H3396_Human1.67509399
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66953571
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65455039
46P300_19829295_ChIP-Seq_ESCs_Human1.64631277
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.63244185
48* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61556639
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59973161
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.58150498
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.53173645
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51991227
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51636463
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51636463
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48757536
56SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48597558
57SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48597558
58TAF15_26573619_Chip-Seq_HEK293_Human1.47873497
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.46656194
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46113757
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.42208086
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41504783
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41072530
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40217980
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37830610
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37187896
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35017066
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34529368
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33121289
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32997143
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32721907
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32330174
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32158164
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31564263
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31564263
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30148580
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.27590673
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.26958665
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26822619
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26253245
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25894002
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24577809
83* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23843126
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23800373
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.23681012
86AR_25329375_ChIP-Seq_VCAP_Human1.22280595
87* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22097145
88SMAD4_21799915_ChIP-Seq_A2780_Human1.21954525
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.21078341
90CLOCK_20551151_ChIP-Seq_293T_Human1.20691709
91JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20314080
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19953096
93REST_21632747_ChIP-Seq_MESCs_Mouse1.19477003
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19469231
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18943778
96ZNF263_19887448_ChIP-Seq_K562_Human1.18943356
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17948093
98RNF2_27304074_Chip-Seq_NSC_Mouse1.17549738
99KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17053237
100AR_21572438_ChIP-Seq_LNCaP_Human1.16508199
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.15150753
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14554543
103STAT3_23295773_ChIP-Seq_U87_Human1.13989056
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13906890
105* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12781869
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12676063
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.12538798
108RUNX2_22187159_ChIP-Seq_PCA_Human1.12430177
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.11343596
110TCF4_23295773_ChIP-Seq_U87_Human1.11186493
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10872246
112BRD4_25478319_ChIP-Seq_HGPS_Human1.10636733
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09885584
114BCAT_22108803_ChIP-Seq_LS180_Human1.09869175
115TTF2_22483619_ChIP-Seq_HELA_Human1.09638457
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09577181
117KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09431112
118RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09359399
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09021097
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07918877
121CBP_20019798_ChIP-Seq_JUKART_Human1.07918877
122CJUN_26792858_Chip-Seq_BT549_Human1.07879817
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.07661406
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07360383
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07157001
126TCF4_22108803_ChIP-Seq_LS180_Human1.07098334
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06843925
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06843925
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06843925
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06767555
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06206217
132XRN2_22483619_ChIP-Seq_HELA_Human1.05610334
133WT1_19549856_ChIP-ChIP_CCG9911_Human1.04435783
134TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02752512
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.01926265
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01737391
137MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01616587
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01337250
139SMAD3_21741376_ChIP-Seq_ESCs_Human1.00256489
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00212472
141SOX2_16153702_ChIP-ChIP_HESCs_Human1.00185806
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00093948
143TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00083897
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00001972
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99536184
146ER_23166858_ChIP-Seq_MCF-7_Human0.99261861
147GATA3_21878914_ChIP-Seq_MCF-7_Human0.97497063
148FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97094461
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.97094461
150UBF1/2_26484160_Chip-Seq_HMECs_Human0.96942195
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96444343
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96089999
153NANOG_19829295_ChIP-Seq_ESCs_Human0.95862201
154SOX2_19829295_ChIP-Seq_ESCs_Human0.95862201
155ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94764658
156CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.93538386
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93077538
158NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92399300
159TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91724253
160MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90958198
161KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88329246
162TP53_18474530_ChIP-ChIP_U2OS_Human0.87964332
163NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86791973
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.86175348
165ATF3_27146783_Chip-Seq_COLON_Human0.85576094
166KLF5_25053715_ChIP-Seq_YYC3_Human0.85331435
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85301511
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85045623
169SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84920313
170POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84808761
171KDM2B_26808549_Chip-Seq_JURKAT_Human0.83218643
172CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83036473
173TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82897667
174E2F1_21310950_ChIP-Seq_MCF-7_Human0.81835991
175SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81059065
176ELK1_22589737_ChIP-Seq_MCF10A_Human0.80922826
177CHD1_26751641_Chip-Seq_LNCaP_Human0.79815358
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79570181
179* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79215358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.42917174
2MP0003136_yellow_coat_color3.39915198
3MP0006292_abnormal_olfactory_placode3.38779523
4MP0010030_abnormal_orbit_morphology3.30461680
5MP0005275_abnormal_skin_tensile2.83507641
6MP0000566_synostosis2.72828348
7MP0000537_abnormal_urethra_morphology2.62988283
8MP0003878_abnormal_ear_physiology2.58092599
9MP0005377_hearing/vestibular/ear_phenot2.58092599
10MP0002796_impaired_skin_barrier2.56056151
11MP0003385_abnormal_body_wall2.31264306
12MP0009053_abnormal_anal_canal2.31064099
13MP0000579_abnormal_nail_morphology2.28400120
14MP0002254_reproductive_system_inflammat2.20137965
15MP0002098_abnormal_vibrissa_morphology2.18969733
16MP0002249_abnormal_larynx_morphology2.14911955
17MP0000383_abnormal_hair_follicle2.02473460
18MP0004885_abnormal_endolymph2.01679200
19MP0000467_abnormal_esophagus_morphology1.99848167
20MP0001188_hyperpigmentation1.96450515
21MP0008877_abnormal_DNA_methylation1.96383649
22MP0009250_abnormal_appendicular_skeleto1.96114607
23MP0000516_abnormal_urinary_system1.92876523
24MP0005367_renal/urinary_system_phenotyp1.92876523
25MP0003315_abnormal_perineum_morphology1.92007511
26MP0003705_abnormal_hypodermis_morpholog1.89510478
27MP0004272_abnormal_basement_membrane1.87789141
28MP0002060_abnormal_skin_morphology1.86500760
29MP0000049_abnormal_middle_ear1.84696272
30MP0000762_abnormal_tongue_morphology1.84510396
31MP0005503_abnormal_tendon_morphology1.81955982
32MP0003937_abnormal_limbs/digits/tail_de1.79964396
33MP0003718_maternal_effect1.77065992
34MP0005501_abnormal_skin_physiology1.74467245
35MP0002282_abnormal_trachea_morphology1.74374229
36MP0001346_abnormal_lacrimal_gland1.74322439
37MP0003755_abnormal_palate_morphology1.72534552
38MP0003123_paternal_imprinting1.71998572
39MP0008438_abnormal_cutaneous_collagen1.71916913
40MP0003942_abnormal_urinary_system1.66216884
41MP0000778_abnormal_nervous_system1.61543008
42MP0001485_abnormal_pinna_reflex1.60747996
43MP0002938_white_spotting1.57636469
44MP0010678_abnormal_skin_adnexa1.57375605
45MP0008789_abnormal_olfactory_epithelium1.56637253
46MP0009379_abnormal_foot_pigmentation1.54335840
47MP0004381_abnormal_hair_follicle1.53920804
48MP0003935_abnormal_craniofacial_develop1.52831522
49MP0000647_abnormal_sebaceous_gland1.51484199
50MP0000428_abnormal_craniofacial_morphol1.46373829
51MP0001984_abnormal_olfaction1.45516870
52MP0002102_abnormal_ear_morphology1.44466107
53MP0003453_abnormal_keratinocyte_physiol1.42418628
54MP0008007_abnormal_cellular_replicative1.42379077
55MP0001216_abnormal_epidermal_layer1.42291209
56MP0002932_abnormal_joint_morphology1.42060456
57MP0010234_abnormal_vibrissa_follicle1.41609912
58MP0005508_abnormal_skeleton_morphology1.40744365
59MP0003119_abnormal_digestive_system1.38328026
60MP0001849_ear_inflammation1.37820862
61MP0002233_abnormal_nose_morphology1.37716463
62MP0002116_abnormal_craniofacial_bone1.35840878
63MP0000377_abnormal_hair_follicle1.35786707
64MP0002177_abnormal_outer_ear1.34628961
65MP0002095_abnormal_skin_pigmentation1.32427557
66MP0005248_abnormal_Harderian_gland1.31897934
67MP0005551_abnormal_eye_electrophysiolog1.31512150
68MP0004133_heterotaxia1.28653993
69MP0010352_gastrointestinal_tract_polyps1.28168768
70MP0000432_abnormal_head_morphology1.27412138
71MP0006054_spinal_hemorrhage1.26977354
72MP0002111_abnormal_tail_morphology1.25989616
73MP0002653_abnormal_ependyma_morphology1.25270869
74MP0005076_abnormal_cell_differentiation1.24723460
75MP0000631_abnormal_neuroendocrine_gland1.23620691
76MP0003011_delayed_dark_adaptation1.23273162
77MP0000733_abnormal_muscle_development1.22514965
78MP0010771_integument_phenotype1.22169405
79MP0009384_cardiac_valve_regurgitation1.20489398
80MP0002234_abnormal_pharynx_morphology1.17927147
81MP0000427_abnormal_hair_cycle1.17075992
82MP0003115_abnormal_respiratory_system1.16126424
83MP0006072_abnormal_retinal_apoptosis1.14689360
84MP0004142_abnormal_muscle_tone1.14095745
85MP0005174_abnormal_tail_pigmentation1.13324138
86MP0001340_abnormal_eyelid_morphology1.13108262
87MP0002109_abnormal_limb_morphology1.11903501
88MP0003938_abnormal_ear_development1.11287374
89MP0003567_abnormal_fetal_cardiomyocyte1.10516474
90MP0003566_abnormal_cell_adhesion1.07740612
91MP0008932_abnormal_embryonic_tissue1.06905471
92MP0000026_abnormal_inner_ear1.06270106
93MP0002160_abnormal_reproductive_system1.05821616
94MP0005023_abnormal_wound_healing1.04518077
95MP0002697_abnormal_eye_size1.04405079
96MP0000534_abnormal_ureter_morphology1.03079672
97MP0003890_abnormal_embryonic-extraembry1.01909362
98MP0001968_abnormal_touch/_nociception1.01478136
99MP0000372_irregular_coat_pigmentation1.01062872
100MP0005499_abnormal_olfactory_system0.99735715
101MP0005394_taste/olfaction_phenotype0.99735715
102MP0003283_abnormal_digestive_organ0.99416671
103MP0002085_abnormal_embryonic_tissue0.99242049
104MP0003693_abnormal_embryo_hatching0.99074257
105MP0001286_abnormal_eye_development0.98866409
106MP0003121_genomic_imprinting0.98529679
107MP0002114_abnormal_axial_skeleton0.98369916
108MP0002084_abnormal_developmental_patter0.98189536
109MP0001529_abnormal_vocalization0.97947855
110MP0005171_absent_coat_pigmentation0.97578392
111MP0005187_abnormal_penis_morphology0.96195399
112MP0005253_abnormal_eye_physiology0.94967255
113MP0004197_abnormal_fetal_growth/weight/0.94587576
114MP0005623_abnormal_meninges_morphology0.93640461
115MP0002751_abnormal_autonomic_nervous0.93619822
116MP0005195_abnormal_posterior_eye0.93385273
117MP0006276_abnormal_autonomic_nervous0.93001392
118MP0005391_vision/eye_phenotype0.92410456
119MP0000678_abnormal_parathyroid_gland0.92002529
120MP0000163_abnormal_cartilage_morphology0.91491928
121MP0001324_abnormal_eye_pigmentation0.91268073
122MP0010094_abnormal_chromosome_stability0.91231820
123MP0001293_anophthalmia0.90807340
124MP0002736_abnormal_nociception_after0.90368440
125MP0001919_abnormal_reproductive_system0.89663827
126MP0002638_abnormal_pupillary_reflex0.89342404
127MP0009046_muscle_twitch0.89208494
128MP0003122_maternal_imprinting0.87792272
129MP0005389_reproductive_system_phenotype0.87350079
130MP0003111_abnormal_nucleus_morphology0.86954988
131MP0002752_abnormal_somatic_nervous0.86827387
132MP0004742_abnormal_vestibular_system0.86538248
133MP0000613_abnormal_salivary_gland0.86363975
134MP0004957_abnormal_blastocyst_morpholog0.85911443
135MP0003861_abnormal_nervous_system0.85391016
136MP0001486_abnormal_startle_reflex0.85288751
137MP0001270_distended_abdomen0.85250045
138MP0002115_abnormal_skeleton_extremities0.84807924
139MP0000015_abnormal_ear_pigmentation0.84779936
140MP0005409_darkened_coat_color0.83903876
141MP0002092_abnormal_eye_morphology0.82142273
142MP0005257_abnormal_intraocular_pressure0.81792363
143MP0008058_abnormal_DNA_repair0.81584702
144MP0002210_abnormal_sex_determination0.79351162
145MP0000462_abnormal_digestive_system0.77287042
146MP0001243_abnormal_dermal_layer0.77034441
147MP0002928_abnormal_bile_duct0.76706523
148MP0004215_abnormal_myocardial_fiber0.76198494
149MP0002113_abnormal_skeleton_development0.75732961
150MP0002557_abnormal_social/conspecific_i0.71847227

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)3.88073113
2Milia (HP:0001056)3.67372679
3Atrophic scars (HP:0001075)3.56305542
4Woolly hair (HP:0002224)3.42430014
5Morphological abnormality of the middle ear (HP:0008609)3.37847190
6Onycholysis (HP:0001806)3.34637226
7Molar tooth sign on MRI (HP:0002419)3.34133134
8Abnormality of midbrain morphology (HP:0002418)3.34133134
9Natal tooth (HP:0000695)3.26545758
10Hypotrichosis (HP:0001006)3.21854816
11Shallow orbits (HP:0000586)3.20738712
12True hermaphroditism (HP:0010459)3.13081452
13Short 4th metacarpal (HP:0010044)3.02343686
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.02343686
15Pancreatic cysts (HP:0001737)3.00586217
16Pancreatic fibrosis (HP:0100732)2.96972077
17Right ventricular cardiomyopathy (HP:0011663)2.93700673
18Type II lissencephaly (HP:0007260)2.92011437
19Plantar hyperkeratosis (HP:0007556)2.90063950
20Premature rupture of membranes (HP:0001788)2.80526462
21Abnormality of secondary sexual hair (HP:0009888)2.60271800
22Abnormality of the axillary hair (HP:0100134)2.60271800
23Nephronophthisis (HP:0000090)2.59510161
24Septo-optic dysplasia (HP:0100842)2.54232152
25Lip pit (HP:0100267)2.52027931
26Pili torti (HP:0003777)2.51923088
27Abnormality of the 4th metacarpal (HP:0010012)2.51151902
28Protrusio acetabuli (HP:0003179)2.50030944
29Bilateral microphthalmos (HP:0007633)2.48329345
30Asymmetry of the thorax (HP:0001555)2.46237543
31Down-sloping shoulders (HP:0200021)2.44328996
32Selective tooth agenesis (HP:0001592)2.35855263
33Abnormality of nail color (HP:0100643)2.35609306
34Advanced eruption of teeth (HP:0006288)2.35597212
35Reticulocytopenia (HP:0001896)2.34260668
36Erythroderma (HP:0001019)2.34151533
37Congenital, generalized hypertrichosis (HP:0004540)2.33391342
38Esophageal atresia (HP:0002032)2.33214812
39Patellar aplasia (HP:0006443)2.33046770
40Abnormality of the labia minora (HP:0012880)2.32006048
41Ridged nail (HP:0001807)2.30570393
42Renal duplication (HP:0000075)2.27068776
43Congenital stationary night blindness (HP:0007642)2.26234678
44Abnormality of the renal medulla (HP:0100957)2.25477142
45Aplasia cutis congenita (HP:0001057)2.23820838
46Supernumerary spleens (HP:0009799)2.22361264
47Medial flaring of the eyebrow (HP:0010747)2.21723006
48Aplasia/Hypoplasia of the patella (HP:0006498)2.21650148
49Fragile skin (HP:0001030)2.21418300
50Pterygium (HP:0001059)2.19948673
51Lissencephaly (HP:0001339)2.19465999
52Oligodactyly (hands) (HP:0001180)2.19439922
53Optic nerve hypoplasia (HP:0000609)2.16829718
54Chronic hepatic failure (HP:0100626)2.15558342
55Hypoplastic labia majora (HP:0000059)2.13909999
56Sclerocornea (HP:0000647)2.13302233
57Cerebellar dysplasia (HP:0007033)2.10116692
58Cutaneous finger syndactyly (HP:0010554)2.08810126
59Nail dystrophy (HP:0008404)2.07479486
60Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05992184
61Labial hypoplasia (HP:0000066)2.05459978
62Non-midline cleft lip (HP:0100335)2.05427253
63Concave nail (HP:0001598)2.05056207
64Atresia of the external auditory canal (HP:0000413)2.04818667
65Palmoplantar hyperkeratosis (HP:0000972)2.04101755
66Hepatoblastoma (HP:0002884)2.03815980
67Hyperacusis (HP:0010780)2.03550003
68Alopecia of scalp (HP:0002293)2.03512431
69Furrowed tongue (HP:0000221)2.03388518
70Breast hypoplasia (HP:0003187)2.02960404
71Absent hair (HP:0002298)2.01102337
72Gait imbalance (HP:0002141)1.99947533
73Palmar hyperkeratosis (HP:0010765)1.99266197
74Colon cancer (HP:0003003)1.98849777
75Abnormality of the nasolacrimal system (HP:0000614)1.98044337
76Genital tract atresia (HP:0001827)1.97865925
77Abnormality of the labia majora (HP:0012881)1.97028094
78Vaginal atresia (HP:0000148)1.94767160
79Sparse scalp hair (HP:0002209)1.93693175
80Absent eyebrow (HP:0002223)1.92653929
81Coronal craniosynostosis (HP:0004440)1.92299145
82Deviation of the hallux (HP:0010051)1.91811108
83Maternal diabetes (HP:0009800)1.90807354
84Midline defect of the nose (HP:0004122)1.90477541
85Abnormality of the 2nd finger (HP:0004100)1.90213538
86Retinal dysplasia (HP:0007973)1.89737135
87Pendular nystagmus (HP:0012043)1.89729468
88Conical tooth (HP:0000698)1.89543764
89Congenital primary aphakia (HP:0007707)1.88595151
9011 pairs of ribs (HP:0000878)1.88365258
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.88326746
92Cystic liver disease (HP:0006706)1.87855893
93Duplicated collecting system (HP:0000081)1.87646563
94Abnormality of the phalanges of the hallux (HP:0010057)1.87505510
95Hypoplastic female external genitalia (HP:0012815)1.85437272
96Anencephaly (HP:0002323)1.84683126
97Fair hair (HP:0002286)1.84150796
98Neonatal short-limb short stature (HP:0008921)1.84090290
99Soft skin (HP:0000977)1.83234234
100Hallux valgus (HP:0001822)1.82929963
101Tubular atrophy (HP:0000092)1.82710548
102Slow-growing hair (HP:0002217)1.82383174
103Abnormality of hair growth rate (HP:0011363)1.82383174
104Rib fusion (HP:0000902)1.82326246
105Cutaneous syndactyly (HP:0012725)1.81936185
106Abnormality of the renal collecting system (HP:0004742)1.81736065
107Amelogenesis imperfecta (HP:0000705)1.81320339
108Anterior segment dysgenesis (HP:0007700)1.81237230
109Nephrogenic diabetes insipidus (HP:0009806)1.81199626
110Fibular aplasia (HP:0002990)1.80830353
111Wrist flexion contracture (HP:0001239)1.80711862
112Abnormality of the lacrimal duct (HP:0011481)1.80582944
113Abnormality of the renal cortex (HP:0011035)1.77296187
114Absent eyelashes (HP:0000561)1.75090650
115Aplasia/Hypoplasia of the ulna (HP:0006495)1.73544627
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.73368591
117Dandy-Walker malformation (HP:0001305)1.72697577
118Oligodactyly (HP:0012165)1.72623080
119Abnormality of the aortic arch (HP:0012303)1.70919209
120Hypoplasia of the fovea (HP:0007750)1.70684791
121Aplasia/Hypoplasia of the fovea (HP:0008060)1.70684791
122Preaxial hand polydactyly (HP:0001177)1.69806999
123Bladder diverticulum (HP:0000015)1.69683818
124Hyperventilation (HP:0002883)1.69192874
125Aortic dissection (HP:0002647)1.67492992
126Overgrowth (HP:0001548)1.67465181
127Hypoplasia of the ulna (HP:0003022)1.67362610
128Popliteal pterygium (HP:0009756)1.67269325
129Broad toe (HP:0001837)1.66990510
130Preaxial foot polydactyly (HP:0001841)1.66522778
131Anonychia (HP:0001798)1.65577323
132Germ cell neoplasia (HP:0100728)1.65459985
133Scrotal hypoplasia (HP:0000046)1.65450159
134Short middle phalanx of the 5th finger (HP:0004220)1.65343586
135Renal dysplasia (HP:0000110)1.65320004
136Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65105126
137Abnormality of the parietal bone (HP:0002696)1.63262818
138Megalencephaly (HP:0001355)1.62338216
139Trismus (HP:0000211)1.62086254
140Ankle contracture (HP:0006466)1.62009573
141Gastrointestinal atresia (HP:0002589)1.61241869
142Male pseudohermaphroditism (HP:0000037)1.60970606
143Hypohidrosis (HP:0000966)1.60523579
144Corneal erosion (HP:0200020)1.60418473
145Postaxial foot polydactyly (HP:0001830)1.60269562
146Pachygyria (HP:0001302)1.58646732
147Partial agenesis of the corpus callosum (HP:0001338)1.57506214
148Increased corneal curvature (HP:0100692)1.56931202
149Keratoconus (HP:0000563)1.56931202
150Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.56663573
151Sparse eyelashes (HP:0000653)1.56488028
152Birth length less than 3rd percentile (HP:0003561)1.56432219
153Absent septum pellucidum (HP:0001331)1.56215962
154Follicular hyperkeratosis (HP:0007502)1.55806700
155Abnormal blistering of the skin (HP:0008066)1.55739277
156Wide anterior fontanel (HP:0000260)1.54871719
157Microglossia (HP:0000171)1.54856204
158Abnormality of the distal phalanx of the thumb (HP:0009617)1.54104694
159Anophthalmia (HP:0000528)1.54098632
160Degeneration of the lateral corticospinal tracts (HP:0002314)1.53705244
161Type 1 muscle fiber predominance (HP:0003803)1.52970588
162Nasolacrimal duct obstruction (HP:0000579)1.51971120
163Abnormality of the gastric mucosa (HP:0004295)1.51303781
164Abnormality of the phalanges of the 5th finger (HP:0004213)1.51120217
165Hypoplastic toenails (HP:0001800)1.51055878
166Laryngomalacia (HP:0001601)1.50409161
167Partial duplication of the phalanx of hand (HP:0009999)1.49838133
168Hypoparathyroidism (HP:0000829)1.49404741
169Abnormality of the labia (HP:0000058)1.49057742
170Sparse lateral eyebrow (HP:0005338)1.48666923
171Aplasia involving bones of the extremities (HP:0009825)1.48617916
172Aplasia involving bones of the upper limbs (HP:0009823)1.48617916
173Aplasia of the phalanges of the hand (HP:0009802)1.48617916
174Curly hair (HP:0002212)1.48557645
175Spinal rigidity (HP:0003306)1.48238174
176Abnormality of dentin (HP:0010299)1.47250704
177Abnormal sex determination (HP:0012244)1.46146299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.99186859
2LATS13.35426002
3PNCK2.63009765
4ADRBK22.58757982
5ERBB32.53103424
6MAPKAPK32.52738142
7FER2.44167734
8LATS22.40936994
9WNK42.38575146
10WNK32.36418943
11RPS6KB22.35462526
12TLK12.24373591
13EEF2K2.22800307
14MAP3K32.13604069
15GRK12.10380711
16MKNK12.08337204
17CASK2.05363568
18DDR22.00375788
19CDC71.87854152
20PDGFRA1.86469904
21MAP3K91.83607659
22MAP3K101.82474885
23STK38L1.79248604
24ACVR1B1.75486528
25NUAK11.74869439
26TGFBR11.71382631
27SRPK11.70924643
28BUB11.67346941
29DYRK21.67113657
30PASK1.61140159
31MAP4K21.60491817
32RPS6KA41.54594390
33PINK11.54252697
34TNIK1.53659726
35MAP3K41.53469300
36TSSK61.52408150
37PAK21.46444166
38DYRK1B1.45811260
39MKNK21.45735694
40LRRK21.43361609
41INSRR1.36368349
42LIMK11.32290218
43DYRK31.30924577
44TESK11.30040988
45FGFR21.29082577
46TRIM281.26069162
47STK161.25095208
48TRIB31.22671442
49CDK81.21646823
50TIE11.21399942
51FGFR11.15086486
52PTK61.13577528
53UHMK11.12616098
54CDK71.11662838
55ILK1.11434093
56PTK21.08840762
57ERBB21.06394152
58STK241.06109445
59TTN1.05593002
60PRKCG1.04438857
61EPHA31.01676574
62PKN21.01107806
63AURKB0.96244340
64MAP3K20.96237024
65CSNK1G10.94515297
66MELK0.93197684
67KSR10.92652440
68PRKCE0.92544023
69PLK30.92219095
70STK390.90952053
71NTRK20.90568950
72TTK0.89847228
73MAP2K70.89812843
74BRSK20.88878484
75STK30.88867370
76STK100.85299068
77CSNK1G20.85145296
78AURKA0.84428850
79PLK10.81454845
80CLK10.80399217
81CDK60.78622353
82CDK30.78620585
83MAPK130.78481696
84EPHA40.78100486
85BRSK10.77944089
86CCNB10.76629098
87NTRK10.76207347
88CAMK1G0.75812614
89ROCK10.74632354
90CDK190.73854849
91CHEK20.72689989
92OXSR10.72239384
93PLK40.71832380
94MAPKAPK50.71133281
95CAMK1D0.70623624
96PAK40.68775374
97WNK10.68767962
98FRK0.68118598
99BCR0.68093728
100MAPKAPK20.67800594
101CDK120.67176881
102CSNK1G30.66562171
103AKT20.66309151
104IRAK20.66247791
105FLT30.66059202
106CDK90.66035791
107CDC42BPA0.64579296
108WEE10.64539222
109RPS6KA10.64348290
110TYRO30.63739063
111MAPK150.62021111
112TAF10.60093098
113PAK30.59904781
114MST1R0.59787746
115MTOR0.59025548
116ATR0.57657110
117PBK0.55964829
118CHEK10.55875273
119RIPK10.55539510
120CSNK1A1L0.55341199
121MARK10.54047351
122NME20.53998420
123NEK90.52983151
124AKT10.52753469
125PRKCI0.52662086
126EPHA20.51960753
127CSNK1E0.51055659
128NEK20.50241499
129MINK10.49862771
130BRAF0.48870200
131ATM0.48770343
132VRK10.48296045
133PIK3CG0.48288790
134NTRK30.48227390
135BMPR1B0.47790473
136ERBB40.47684599
137MAP3K80.47221942
138CDK20.47135973
139ADRBK10.46733123
140ARAF0.46376658
141IRAK10.46232304
142PLK20.45844838
143PIK3CA0.45761526
144ZAK0.45505598
145MET0.45267853
146MAP2K40.44191061
147CSNK1D0.40001184
148RPS6KA50.37390884
149DMPK0.34214112
150DYRK1A0.34073890
151PRKACA0.30241496
152SGK4940.29684452
153SGK2230.29684452

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.28441828
2Ribosome_Homo sapiens_hsa030103.01766305
3Phototransduction_Homo sapiens_hsa047442.73561027
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.72566135
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.69032980
6Selenocompound metabolism_Homo sapiens_hsa004502.60056368
7* Hippo signaling pathway_Homo sapiens_hsa043902.55038986
8Hedgehog signaling pathway_Homo sapiens_hsa043402.54352644
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.25496241
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.21831839
11Cell cycle_Homo sapiens_hsa041102.15223258
12Spliceosome_Homo sapiens_hsa030402.02646180
13TGF-beta signaling pathway_Homo sapiens_hsa043502.00539407
14Ether lipid metabolism_Homo sapiens_hsa005651.99157793
15ECM-receptor interaction_Homo sapiens_hsa045121.97778983
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94860577
17DNA replication_Homo sapiens_hsa030301.90305738
18Steroid biosynthesis_Homo sapiens_hsa001001.87420914
19MicroRNAs in cancer_Homo sapiens_hsa052061.86490784
20Adherens junction_Homo sapiens_hsa045201.85222578
21Wnt signaling pathway_Homo sapiens_hsa043101.81995228
22Homologous recombination_Homo sapiens_hsa034401.81449426
23p53 signaling pathway_Homo sapiens_hsa041151.74545759
24Nicotine addiction_Homo sapiens_hsa050331.73747490
25Axon guidance_Homo sapiens_hsa043601.68994917
26Small cell lung cancer_Homo sapiens_hsa052221.68348053
27Protein export_Homo sapiens_hsa030601.65314137
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63881421
29RNA transport_Homo sapiens_hsa030131.62987441
30mRNA surveillance pathway_Homo sapiens_hsa030151.59839003
31Notch signaling pathway_Homo sapiens_hsa043301.58801823
32Bladder cancer_Homo sapiens_hsa052191.56733005
33Butanoate metabolism_Homo sapiens_hsa006501.53335671
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.52624487
35Proteoglycans in cancer_Homo sapiens_hsa052051.51780963
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50255217
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49021968
38Mismatch repair_Homo sapiens_hsa034301.45352936
39Nitrogen metabolism_Homo sapiens_hsa009101.44020354
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42934229
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41957609
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41296177
43Fanconi anemia pathway_Homo sapiens_hsa034601.41011401
44HTLV-I infection_Homo sapiens_hsa051661.39269375
45Endometrial cancer_Homo sapiens_hsa052131.39170632
46Focal adhesion_Homo sapiens_hsa045101.38290515
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35150329
48Colorectal cancer_Homo sapiens_hsa052101.34691967
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33402736
50Oxidative phosphorylation_Homo sapiens_hsa001901.28261714
51Melanogenesis_Homo sapiens_hsa049161.27884998
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.22623923
53Pathways in cancer_Homo sapiens_hsa052001.21880628
54RNA degradation_Homo sapiens_hsa030181.17778154
55Chronic myeloid leukemia_Homo sapiens_hsa052201.17091243
56* Tight junction_Homo sapiens_hsa045301.16515297
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16492504
58RNA polymerase_Homo sapiens_hsa030201.15713192
59Nucleotide excision repair_Homo sapiens_hsa034201.12804361
60Base excision repair_Homo sapiens_hsa034101.12110366
61Thyroid cancer_Homo sapiens_hsa052161.11768202
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09619432
63Olfactory transduction_Homo sapiens_hsa047401.08583202
64Serotonergic synapse_Homo sapiens_hsa047261.07196297
65Melanoma_Homo sapiens_hsa052181.05510400
66Cardiac muscle contraction_Homo sapiens_hsa042601.05481002
67Maturity onset diabetes of the young_Homo sapiens_hsa049501.04675662
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04142671
69Parkinsons disease_Homo sapiens_hsa050121.03278078
70Prostate cancer_Homo sapiens_hsa052151.02291496
71Caffeine metabolism_Homo sapiens_hsa002321.00931872
72Glutamatergic synapse_Homo sapiens_hsa047241.00735520
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.96473530
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95912624
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95073264
76Morphine addiction_Homo sapiens_hsa050320.94845959
77Pancreatic cancer_Homo sapiens_hsa052120.93997020
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93345696
79Tryptophan metabolism_Homo sapiens_hsa003800.93018726
80Propanoate metabolism_Homo sapiens_hsa006400.92300061
81Basal transcription factors_Homo sapiens_hsa030220.91235865
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91025503
83Fat digestion and absorption_Homo sapiens_hsa049750.90356277
84Taste transduction_Homo sapiens_hsa047420.89844386
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89796207
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89597287
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88107332
88Huntingtons disease_Homo sapiens_hsa050160.86901706
89Oocyte meiosis_Homo sapiens_hsa041140.86263850
90Circadian entrainment_Homo sapiens_hsa047130.85183122
91Amoebiasis_Homo sapiens_hsa051460.84720859
92Ovarian steroidogenesis_Homo sapiens_hsa049130.82989425
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81350276
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78791948
95Dopaminergic synapse_Homo sapiens_hsa047280.77089733
96Dorso-ventral axis formation_Homo sapiens_hsa043200.76203593
97Long-term depression_Homo sapiens_hsa047300.75926741
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75144493
99Arachidonic acid metabolism_Homo sapiens_hsa005900.73984793
100GABAergic synapse_Homo sapiens_hsa047270.73458858
101One carbon pool by folate_Homo sapiens_hsa006700.72720601
102Viral myocarditis_Homo sapiens_hsa054160.72430916
103N-Glycan biosynthesis_Homo sapiens_hsa005100.71384579
104Toxoplasmosis_Homo sapiens_hsa051450.70979014
105Glioma_Homo sapiens_hsa052140.70836473
106Gap junction_Homo sapiens_hsa045400.69501425
107Renal cell carcinoma_Homo sapiens_hsa052110.68478500
108ErbB signaling pathway_Homo sapiens_hsa040120.68468224
109Viral carcinogenesis_Homo sapiens_hsa052030.67938850
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67375894
111Non-homologous end-joining_Homo sapiens_hsa034500.66934819
112Retinol metabolism_Homo sapiens_hsa008300.65548007
113VEGF signaling pathway_Homo sapiens_hsa043700.65195345
114Fatty acid elongation_Homo sapiens_hsa000620.64904450
115Herpes simplex infection_Homo sapiens_hsa051680.64748262
116Alzheimers disease_Homo sapiens_hsa050100.64620584
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64506227
118* Rap1 signaling pathway_Homo sapiens_hsa040150.64290529
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61772649
120Peroxisome_Homo sapiens_hsa041460.61751917
121Epstein-Barr virus infection_Homo sapiens_hsa051690.61382603
122Protein digestion and absorption_Homo sapiens_hsa049740.61377424
123Sphingolipid metabolism_Homo sapiens_hsa006000.61073335
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.60775028
125Purine metabolism_Homo sapiens_hsa002300.60201893
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.59112080
127Hepatitis B_Homo sapiens_hsa051610.57484150
128Prolactin signaling pathway_Homo sapiens_hsa049170.56690301
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56620509
130Dilated cardiomyopathy_Homo sapiens_hsa054140.56381559
131Sulfur relay system_Homo sapiens_hsa041220.55733636
132Estrogen signaling pathway_Homo sapiens_hsa049150.55590067
133Histidine metabolism_Homo sapiens_hsa003400.54673945
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54513278
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.53758098
136Metabolic pathways_Homo sapiens_hsa011000.53149433
137Vitamin digestion and absorption_Homo sapiens_hsa049770.52992518
138Lysine degradation_Homo sapiens_hsa003100.52313453
139Ras signaling pathway_Homo sapiens_hsa040140.51551489
140Regulation of autophagy_Homo sapiens_hsa041400.51511494
141Non-small cell lung cancer_Homo sapiens_hsa052230.51356131
142Pyrimidine metabolism_Homo sapiens_hsa002400.50403009
143Arginine and proline metabolism_Homo sapiens_hsa003300.50161187
144ABC transporters_Homo sapiens_hsa020100.49338208
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48200827
146Chemical carcinogenesis_Homo sapiens_hsa052040.47616422
147Proteasome_Homo sapiens_hsa030500.46450090
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46093741
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.46000179
150FoxO signaling pathway_Homo sapiens_hsa040680.45675029
151GnRH signaling pathway_Homo sapiens_hsa049120.45610956
152Acute myeloid leukemia_Homo sapiens_hsa052210.45590067
153beta-Alanine metabolism_Homo sapiens_hsa004100.44855138
154Linoleic acid metabolism_Homo sapiens_hsa005910.43994012
155Apoptosis_Homo sapiens_hsa042100.43991849
156Antigen processing and presentation_Homo sapiens_hsa046120.42701368
157Glycerolipid metabolism_Homo sapiens_hsa005610.42646364
158Circadian rhythm_Homo sapiens_hsa047100.42225058
159Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41979814
160Insulin secretion_Homo sapiens_hsa049110.39780470
161Cholinergic synapse_Homo sapiens_hsa047250.39489415
162Alcoholism_Homo sapiens_hsa050340.38018990
163Jak-STAT signaling pathway_Homo sapiens_hsa046300.37797451
164Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37761445
165Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37567760

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