PAQR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of myeloid cell apoptotic process (GO:0033033)8.29709921
2histone H3-K4 trimethylation (GO:0080182)6.56517616
3cellular response to ATP (GO:0071318)5.42405673
4regulation of myeloid cell apoptotic process (GO:0033032)5.21594706
5response to pheromone (GO:0019236)5.15131552
6alternative mRNA splicing, via spliceosome (GO:0000380)4.83782390
7regulation of DNA endoreduplication (GO:0032875)4.83267687
8regulation of hypersensitivity (GO:0002883)4.61436665
9positive regulation of megakaryocyte differentiation (GO:0045654)4.48630823
10proline transport (GO:0015824)4.33232746
11glycine transport (GO:0015816)4.24636464
12positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.20146140
13sequestering of metal ion (GO:0051238)4.10034541
14DNA topological change (GO:0006265)4.07130729
15nuclear pore organization (GO:0006999)3.87258981
16cellular extravasation (GO:0045123)3.84120678
17cranial nerve morphogenesis (GO:0021602)3.82862994
18superoxide anion generation (GO:0042554)3.76312267
19alanine transport (GO:0032328)3.72123065
20negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.60588241
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.59929543
22hepatocyte differentiation (GO:0070365)3.59830770
23nuclear pore complex assembly (GO:0051292)3.56445295
24pyrimidine nucleobase catabolic process (GO:0006208)3.50293880
25osteoblast development (GO:0002076)3.50287533
26neutrophil activation involved in immune response (GO:0002283)3.49051378
27negative regulation of neurotransmitter secretion (GO:0046929)3.45505410
28resolution of meiotic recombination intermediates (GO:0000712)3.38991651
29neutrophil mediated immunity (GO:0002446)3.33098622
30DNA unwinding involved in DNA replication (GO:0006268)3.32504841
31spermatid nucleus differentiation (GO:0007289)3.31674744
32peptidyl-lysine trimethylation (GO:0018023)3.29546759
33modulation by virus of host process (GO:0019054)3.29353112
34negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.28655587
35interkinetic nuclear migration (GO:0022027)3.28205056
36negative regulation of T cell mediated immunity (GO:0002710)3.27991545
37ether lipid metabolic process (GO:0046485)3.25862647
38neutrophil activation (GO:0042119)3.23767966
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23232508
40DNA double-strand break processing (GO:0000729)3.22840674
41G-protein coupled receptor internalization (GO:0002031)3.21656176
42monoubiquitinated protein deubiquitination (GO:0035520)3.19272750
43positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.13994226
44regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.10225831
45DNA ligation (GO:0006266)3.07220869
46regulation of histone H3-K4 methylation (GO:0051569)3.06925667
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06084023
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.06084023
49modulation by symbiont of host immune response (GO:0052553)3.06084023
50positive regulation by symbiont of host defense response (GO:0052509)3.06084023
51modulation by symbiont of host defense response (GO:0052031)3.06084023
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06084023
53negative regulation of DNA recombination (GO:0045910)3.05903581
54DNA damage response, detection of DNA damage (GO:0042769)3.04750704
55glutamate receptor signaling pathway (GO:0007215)3.04205613
56double-strand break repair via nonhomologous end joining (GO:0006303)3.02816907
57non-recombinational repair (GO:0000726)3.02816907
58opioid receptor signaling pathway (GO:0038003)3.00907493
59inositol metabolic process (GO:0006020)2.99354039
60glucocorticoid receptor signaling pathway (GO:0042921)2.97164303
61response to host immune response (GO:0052572)2.95553600
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.95553600
63neural tube formation (GO:0001841)2.93305032
64production of molecular mediator involved in inflammatory response (GO:0002532)2.93072990
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92852606
66regulation of mast cell activation (GO:0033003)2.90873021
67granulocyte activation (GO:0036230)2.90577776
68histone H3-K4 methylation (GO:0051568)2.89440327
69modulation by symbiont of host cellular process (GO:0044068)2.89187099
70presynaptic membrane assembly (GO:0097105)2.88122217
71establishment of mitochondrion localization (GO:0051654)2.84318678
72epithelial cell differentiation involved in kidney development (GO:0035850)2.84056849
73neuron cell-cell adhesion (GO:0007158)2.82985629
74positive regulation of histone H3-K4 methylation (GO:0051571)2.82633083
75long-term memory (GO:0007616)2.81814801
76regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81694183
77negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80888806
78positive regulation of cellular amide metabolic process (GO:0034250)2.80821734
79gamma-aminobutyric acid signaling pathway (GO:0007214)2.79357117
80myeloid leukocyte mediated immunity (GO:0002444)2.78794549
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77744616
82regulation of glutamate receptor signaling pathway (GO:1900449)2.77713727
83ribonucleoprotein complex disassembly (GO:0032988)2.73836234
84regulation of integrin activation (GO:0033623)2.73756478
85negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73718664
86regulation of activation of Janus kinase activity (GO:0010533)2.72790419
87mitochondrial fission (GO:0000266)2.71456809
88negative regulation of neurotransmitter transport (GO:0051589)2.70948143
89regulation of female gonad development (GO:2000194)2.70812849
90presynaptic membrane organization (GO:0097090)2.68006889
91protein localization to synapse (GO:0035418)2.66728623
92sister chromatid cohesion (GO:0007062)2.65856841
93chromatin remodeling at centromere (GO:0031055)2.65728460
94centriole replication (GO:0007099)2.65466579
95pore complex assembly (GO:0046931)2.65302403
96synapsis (GO:0007129)2.63846377
97CENP-A containing nucleosome assembly (GO:0034080)2.60182306
98protein targeting to peroxisome (GO:0006625)2.59637621
99establishment of protein localization to peroxisome (GO:0072663)2.59637621
100protein localization to peroxisome (GO:0072662)2.59637621
101mechanosensory behavior (GO:0007638)2.59071063
102regulation of protein polyubiquitination (GO:1902914)2.57824868
103mast cell activation (GO:0045576)2.57742451
104drinking behavior (GO:0042756)2.56536429
105positive regulation of cell size (GO:0045793)2.56464132
106positive regulation of fibroblast migration (GO:0010763)2.56457417
107regulation of RNA export from nucleus (GO:0046831)2.56328652
108vocalization behavior (GO:0071625)2.55699519
109B cell homeostasis (GO:0001782)2.55251039
110regulation of sister chromatid cohesion (GO:0007063)2.55230568
111energy homeostasis (GO:0097009)2.55123741
112postsynaptic membrane organization (GO:0001941)2.54923850
113central nervous system projection neuron axonogenesis (GO:0021952)2.54504127
114regulation of mast cell degranulation (GO:0043304)2.53486751
115synaptic transmission, glutamatergic (GO:0035249)2.52657987
116cellular defense response (GO:0006968)2.52394383
117response to host (GO:0075136)2.52315101
118response to host defenses (GO:0052200)2.52315101
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52315101
120establishment of integrated proviral latency (GO:0075713)2.49539037
121positive regulation of dendritic spine development (GO:0060999)2.49450861
122neuron remodeling (GO:0016322)2.49021001
123regulation of meiosis I (GO:0060631)2.48394248
124positive regulation of CREB transcription factor activity (GO:0032793)2.48281279
125positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47319326
126magnesium ion transport (GO:0015693)2.46732061
127mRNA stabilization (GO:0048255)2.46133767
128RNA stabilization (GO:0043489)2.46133767
129startle response (GO:0001964)2.45972551
130microtubule depolymerization (GO:0007019)2.45788181
131mitochondrion transport along microtubule (GO:0047497)2.45107471
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45107471
133positive regulation of mitochondrial fission (GO:0090141)2.44056187
134nerve growth factor signaling pathway (GO:0038180)2.43299158
135positive regulation of dendritic spine morphogenesis (GO:0061003)2.43068546
136microtubule anchoring (GO:0034453)2.42097294
137nucleobase catabolic process (GO:0046113)2.41967494
138limb bud formation (GO:0060174)2.41920238
139negative regulation of calcium ion transport into cytosol (GO:0010523)2.41573467
140proteasome assembly (GO:0043248)2.41244768
141actin filament polymerization (GO:0030041)2.40543767
142corticosteroid receptor signaling pathway (GO:0031958)2.40209054
143male sex determination (GO:0030238)2.39999185
144exogenous drug catabolic process (GO:0042738)2.39899656
145regulation of synaptic vesicle exocytosis (GO:2000300)2.39538914
146regulation of B cell receptor signaling pathway (GO:0050855)2.38200427
147negative thymic T cell selection (GO:0045060)2.36271380
148mitotic sister chromatid cohesion (GO:0007064)2.36162217
149regulation of mast cell activation involved in immune response (GO:0033006)2.36068659
150neurotransmitter-gated ion channel clustering (GO:0072578)2.35337123
151microtubule polymerization or depolymerization (GO:0031109)2.34590663
152negative regulation of DNA-dependent DNA replication (GO:2000104)2.34216274
153glycerol ether metabolic process (GO:0006662)2.33700076
154intra-S DNA damage checkpoint (GO:0031573)2.33681183
155histone exchange (GO:0043486)2.31666664
156attachment of spindle microtubules to kinetochore (GO:0008608)2.31656949
157neurofilament cytoskeleton organization (GO:0060052)2.31566371
158regulation of helicase activity (GO:0051095)2.30504145
159behavioral response to ethanol (GO:0048149)2.30377274
160axonal fasciculation (GO:0007413)2.30247979
161regulation of dendritic spine morphogenesis (GO:0061001)2.29926011
162neuron recognition (GO:0008038)2.29370699
163regulation of feeding behavior (GO:0060259)2.28806048
164regulation of centriole replication (GO:0046599)2.28232740
165generation of neurons (GO:0048699)2.27310350
166telomere maintenance via telomerase (GO:0007004)2.25620704
167protein localization to chromosome, centromeric region (GO:0071459)2.25459422
168meiotic cell cycle (GO:0051321)2.25230598
169protein-cofactor linkage (GO:0018065)2.23824068
170sister chromatid segregation (GO:0000819)2.23180935
171ether metabolic process (GO:0018904)2.22065971
172mRNA splice site selection (GO:0006376)2.21872353
173centrosome duplication (GO:0051298)2.21800587
174peroxisome fission (GO:0016559)2.21607860
175regulation of cAMP-dependent protein kinase activity (GO:2000479)2.21517723
176formation of translation preinitiation complex (GO:0001731)2.18590892
177regulation of growth hormone secretion (GO:0060123)2.17766244
178regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.17554914
179protein localization to kinetochore (GO:0034501)2.16775149
180spinal cord development (GO:0021510)2.15882723
181heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.15092295
182dendrite morphogenesis (GO:0048813)2.14521534
183ncRNA catabolic process (GO:0034661)2.14413410
184histone H2A monoubiquitination (GO:0035518)2.14122289
185necroptotic process (GO:0070266)2.13122866
186peroxisomal transport (GO:0043574)2.12852659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.66676286
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.13428422
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.88764766
4GBX2_23144817_ChIP-Seq_PC3_Human3.71462793
5EZH2_22144423_ChIP-Seq_EOC_Human3.20164888
6E2F7_22180533_ChIP-Seq_HELA_Human3.18484093
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79926309
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51815430
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42195912
10IGF1R_20145208_ChIP-Seq_DFB_Human2.31259201
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29773488
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28689654
13TP53_16413492_ChIP-PET_HCT116_Human2.21549717
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08133621
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04586015
16TAF15_26573619_Chip-Seq_HEK293_Human2.01457185
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99925157
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97332276
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94052740
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93989400
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93567685
22ELK1_19687146_ChIP-ChIP_HELA_Human1.87134377
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85643969
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.83130040
25FUS_26573619_Chip-Seq_HEK293_Human1.82706354
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81007469
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80949865
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80868079
29P300_19829295_ChIP-Seq_ESCs_Human1.79707469
30DROSHA_22980978_ChIP-Seq_HELA_Human1.78595653
31ZNF274_21170338_ChIP-Seq_K562_Hela1.76761552
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.74362746
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74286066
34RNF2_27304074_Chip-Seq_NSC_Mouse1.74144202
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74016575
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73505463
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.70606785
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69222679
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68677971
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.67853189
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.67511707
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.67103312
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.66849163
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65509432
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65421496
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63860092
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63714114
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63134101
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61823612
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.57428264
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.55138274
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.55055830
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54026093
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.53495190
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53335473
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52523836
57P53_22387025_ChIP-Seq_ESCs_Mouse1.50081515
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49645343
59* SMAD4_21799915_ChIP-Seq_A2780_Human1.49202903
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.47444859
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45980026
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.45705565
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45567027
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.45416884
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45170213
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44152785
67VDR_22108803_ChIP-Seq_LS180_Human1.42163412
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.42114634
69EWS_26573619_Chip-Seq_HEK293_Human1.40887690
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40084173
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39312206
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38973457
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.36329740
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36105879
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35822081
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35534798
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.33791202
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33617221
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33617221
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33457636
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33315776
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32403631
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31912172
84MYC_18940864_ChIP-ChIP_HL60_Human1.31502155
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.30841726
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30184133
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28967619
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.28216455
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27407058
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.26967136
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25764504
92TCF4_23295773_ChIP-Seq_U87_Human1.25677718
93P300_18555785_Chip-Seq_ESCs_Mouse1.25522015
94AR_21572438_ChIP-Seq_LNCaP_Human1.24412234
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.24246217
96STAT3_23295773_ChIP-Seq_U87_Human1.24109425
97TP53_18474530_ChIP-ChIP_U2OS_Human1.23826564
98NMYC_18555785_Chip-Seq_ESCs_Mouse1.23359289
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22523470
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.22466500
101AR_25329375_ChIP-Seq_VCAP_Human1.21531873
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20905621
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20905621
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20817441
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20463211
106SCL_19346495_ChIP-Seq_HPC-7_Human1.20346960
107SOX2_16153702_ChIP-ChIP_HESCs_Human1.20228231
108CBP_20019798_ChIP-Seq_JUKART_Human1.20131305
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20131305
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20071283
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18822465
112* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18718572
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18487577
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18446102
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18442675
116RNF2_27304074_Chip-Seq_ESCs_Mouse1.18281131
117ER_23166858_ChIP-Seq_MCF-7_Human1.18200215
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.18085994
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17738805
120CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15873624
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.15829291
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.15733211
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15330636
124YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14603812
125* JUN_21703547_ChIP-Seq_K562_Human1.14392534
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14121909
127SOX9_26525672_Chip-Seq_HEART_Mouse1.14108135
128MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13699245
129* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12983764
130PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12932366
131IRF8_27001747_Chip-Seq_BMDM_Mouse1.12496308
132REST_21632747_ChIP-Seq_MESCs_Mouse1.12154843
133RUNX1_27457419_Chip-Seq_LIVER_Mouse1.11998666
134PU1_27457419_Chip-Seq_LIVER_Mouse1.11261349
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10723062
136CTCF_18555785_Chip-Seq_ESCs_Mouse1.10323434
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09685429
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08319453
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07041049
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06611686
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06538358
142AHR_22903824_ChIP-Seq_MCF-7_Human1.05246630
143EZH2_27294783_Chip-Seq_ESCs_Mouse1.04998927
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04849996
145KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04846160
146* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03919326
147RUNX2_22187159_ChIP-Seq_PCA_Human1.03484997
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02094619
149ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01879636
150* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01573313
151IRF1_19129219_ChIP-ChIP_H3396_Human1.00289490
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98994030
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98984023
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98960799
155CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98535493
156POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98265900
157EST1_17652178_ChIP-ChIP_JURKAT_Human0.97887055
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97024554
159TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96052272
160AR_21909140_ChIP-Seq_LNCAP_Human0.95510300
161MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94956782
162TTF2_22483619_ChIP-Seq_HELA_Human0.94015291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland5.55035336
2MP0002163_abnormal_gland_morphology5.48026883
3MP0005379_endocrine/exocrine_gland_phen3.65898234
4MP0008057_abnormal_DNA_replication3.45307118
5MP0003436_decreased_susceptibility_to3.16513361
6MP0001188_hyperpigmentation2.91380195
7MP0003183_abnormal_peptide_metabolism2.90143652
8MP0003303_peritoneal_inflammation2.88352009
9MP0008877_abnormal_DNA_methylation2.80526907
10MP0005645_abnormal_hypothalamus_physiol2.72256415
11MP0000681_abnormal_thyroid_gland2.71797855
12MP0004859_abnormal_synaptic_plasticity2.56808388
13MP0006292_abnormal_olfactory_placode2.54979876
14MP0002735_abnormal_chemical_nociception2.40478146
15MP0004185_abnormal_adipocyte_glucose2.35700719
16MP0002234_abnormal_pharynx_morphology2.28657870
17MP0001529_abnormal_vocalization2.25871368
18MP0000569_abnormal_digit_pigmentation2.25580608
19MP0005310_abnormal_salivary_gland2.18122314
20MP0008058_abnormal_DNA_repair2.15291935
21MP0001486_abnormal_startle_reflex2.06436372
22MP0002736_abnormal_nociception_after2.05053424
23MP0005409_darkened_coat_color2.02827368
24MP0003718_maternal_effect1.98807593
25MP0003880_abnormal_central_pattern1.98654125
26MP0001968_abnormal_touch/_nociception1.87730314
27MP0005646_abnormal_pituitary_gland1.86870590
28MP0003635_abnormal_synaptic_transmissio1.86870313
29MP0005076_abnormal_cell_differentiation1.82712671
30MP0010094_abnormal_chromosome_stability1.78784247
31MP0002102_abnormal_ear_morphology1.77420480
32MP0004808_abnormal_hematopoietic_stem1.75387295
33MP0002063_abnormal_learning/memory/cond1.69131593
34MP0004957_abnormal_blastocyst_morpholog1.68130825
35MP0005464_abnormal_platelet_physiology1.65651310
36MP0006276_abnormal_autonomic_nervous1.65426415
37MP0003787_abnormal_imprinting1.64507712
38MP0003937_abnormal_limbs/digits/tail_de1.60774224
39MP0002419_abnormal_innate_immunity1.60681992
40MP0005187_abnormal_penis_morphology1.59601983
41MP0004147_increased_porphyrin_level1.58884209
42MP0002734_abnormal_mechanical_nocicepti1.58510158
43MP0001293_anophthalmia1.56925087
44MP0002822_catalepsy1.54072479
45MP0000678_abnormal_parathyroid_gland1.53497821
46MP0009745_abnormal_behavioral_response1.51440988
47MP0003315_abnormal_perineum_morphology1.49728566
48MP0004811_abnormal_neuron_physiology1.46964023
49MP0005000_abnormal_immune_tolerance1.44675809
50MP0005423_abnormal_somatic_nervous1.41539664
51MP0008932_abnormal_embryonic_tissue1.38298882
52MP0001533_abnormal_skeleton_physiology1.34206105
53MP0003567_abnormal_fetal_cardiomyocyte1.33828965
54MP0002572_abnormal_emotion/affect_behav1.33560579
55MP0008004_abnormal_stomach_pH1.32586940
56MP0003283_abnormal_digestive_organ1.32182816
57MP0003385_abnormal_body_wall1.29324004
58MP0009046_muscle_twitch1.29143211
59MP0003119_abnormal_digestive_system1.27405707
60MP0003077_abnormal_cell_cycle1.26124545
61MP0001177_atelectasis1.25203728
62MP0003111_abnormal_nucleus_morphology1.22948666
63MP0001440_abnormal_grooming_behavior1.21151500
64MP0003861_abnormal_nervous_system1.20569823
65MP0002928_abnormal_bile_duct1.18688608
66MP0003828_pulmonary_edema1.17029884
67MP0001970_abnormal_pain_threshold1.16477279
68MP0003300_gastrointestinal_ulcer1.16250446
69MP0002160_abnormal_reproductive_system1.15771522
70MP0003122_maternal_imprinting1.15150400
71MP0002064_seizures1.14626680
72MP0003121_genomic_imprinting1.14204350
73MP0001984_abnormal_olfaction1.13767619
74MP0000566_synostosis1.13266257
75MP0009250_abnormal_appendicular_skeleto1.13266170
76MP0003172_abnormal_lysosome_physiology1.13010503
77MP0000955_abnormal_spinal_cord1.11598157
78MP0003890_abnormal_embryonic-extraembry1.11230559
79MP0003693_abnormal_embryo_hatching1.10751864
80MP0009703_decreased_birth_body1.10657796
81MP0003123_paternal_imprinting1.10062350
82MP0002233_abnormal_nose_morphology1.09826252
83MP0002751_abnormal_autonomic_nervous1.09730000
84MP0003935_abnormal_craniofacial_develop1.09273134
85MP0002067_abnormal_sensory_capabilities1.08623686
86MP0002148_abnormal_hypersensitivity_rea1.07934073
87MP0004924_abnormal_behavior1.07862094
88MP0005386_behavior/neurological_phenoty1.07862094
89MP0004270_analgesia1.07301988
90MP0002132_abnormal_respiratory_system1.07053796
91MP0005171_absent_coat_pigmentation1.06089577
92MP0002084_abnormal_developmental_patter1.03939194
93MP0009697_abnormal_copulation1.02008811
94MP0005084_abnormal_gallbladder_morpholo1.01780209
95MP0001286_abnormal_eye_development1.01233588
96MP0003698_abnormal_male_reproductive0.99440625
97MP0002697_abnormal_eye_size0.98460358
98MP0001299_abnormal_eye_distance/0.98180105
99MP0001929_abnormal_gametogenesis0.96314890
100MP0002396_abnormal_hematopoietic_system0.95963020
101MP0002152_abnormal_brain_morphology0.95600460
102MP0000049_abnormal_middle_ear0.95239975
103MP0002210_abnormal_sex_determination0.95070492
104MP0003755_abnormal_palate_morphology0.94910441
105MP0000613_abnormal_salivary_gland0.94677153
106MP0001835_abnormal_antigen_presentation0.94560713
107MP0005025_abnormal_response_to0.94233893
108MP0003221_abnormal_cardiomyocyte_apopto0.92400437
109MP0001879_abnormal_lymphatic_vessel0.91999764
110MP0001851_eye_inflammation0.91955274
111MP0002452_abnormal_antigen_presenting0.91849122
112MP0001501_abnormal_sleep_pattern0.91687694
113MP0004197_abnormal_fetal_growth/weight/0.90838043
114MP0003045_fibrosis0.90382060
115MP0002277_abnormal_respiratory_mucosa0.89912330
116MP0002085_abnormal_embryonic_tissue0.89786067
117MP0002723_abnormal_immune_serum0.89754502
118MP0001986_abnormal_taste_sensitivity0.89245091
119MP0005671_abnormal_response_to0.88633899
120MP0002882_abnormal_neuron_morphology0.88387474
121MP0003566_abnormal_cell_adhesion0.86666137
122MP0002638_abnormal_pupillary_reflex0.86428379
123MP0002081_perinatal_lethality0.86385770
124MP0009764_decreased_sensitivity_to0.86043359
125MP0000350_abnormal_cell_proliferation0.85045634
126MP0002557_abnormal_social/conspecific_i0.84907678
127MP0001697_abnormal_embryo_size0.84725211
128MP0004782_abnormal_surfactant_physiolog0.83776301
129MP0002249_abnormal_larynx_morphology0.83533383
130MP0001800_abnormal_humoral_immune0.83339879
131MP0004885_abnormal_endolymph0.82514818
132MP0003868_abnormal_feces_composition0.81838548
133MP0003938_abnormal_ear_development0.81000213
134MP0001790_abnormal_immune_system0.80935448
135MP0005387_immune_system_phenotype0.80935448
136MP0000428_abnormal_craniofacial_morphol0.79656338
137MP0000631_abnormal_neuroendocrine_gland0.79530177
138MP0001819_abnormal_immune_cell0.79230716
139MP0001672_abnormal_embryogenesis/_devel0.79141325
140MP0005380_embryogenesis_phenotype0.79141325
141MP0001730_embryonic_growth_arrest0.79127384
142MP0002420_abnormal_adaptive_immunity0.78970124
143MP0001340_abnormal_eyelid_morphology0.78626290
144MP0001764_abnormal_homeostasis0.78385117
145MP0000778_abnormal_nervous_system0.78359655
146MP0004215_abnormal_myocardial_fiber0.78228639
147MP0000462_abnormal_digestive_system0.78167208
148MP0001270_distended_abdomen0.78152549
149MP0009780_abnormal_chondrocyte_physiolo0.78078649
150MP0002184_abnormal_innervation0.76832304
151MP0001943_abnormal_respiration0.76726905
152MP0001845_abnormal_inflammatory_respons0.76637371
153MP0006072_abnormal_retinal_apoptosis0.76588518
154MP0004742_abnormal_vestibular_system0.76439648
155MP0005623_abnormal_meninges_morphology0.75356826
156MP0008007_abnormal_cellular_replicative0.74780077
157MP0000653_abnormal_sex_gland0.74464469
158MP0000858_altered_metastatic_potential0.72144860
159MP0000015_abnormal_ear_pigmentation0.71901491
160MP0005397_hematopoietic_system_phenotyp0.71672159
161MP0001545_abnormal_hematopoietic_system0.71672159
162MP0000920_abnormal_myelination0.71000231
163MP0001502_abnormal_circadian_rhythm0.69710774
164MP0002272_abnormal_nervous_system0.68866778
165MP0009672_abnormal_birth_weight0.67226437
166MP0005174_abnormal_tail_pigmentation0.67067237
167MP0003943_abnormal_hepatobiliary_system0.66661000
168MP0002282_abnormal_trachea_morphology0.65159406
169MP0002127_abnormal_cardiovascular_syste0.64941292

Predicted human phenotypes

RankGene SetZ-score
1Acute lymphatic leukemia (HP:0006721)6.45230296
2Eczematoid dermatitis (HP:0000976)4.62535170
3Febrile seizures (HP:0002373)4.51597474
4Metaphyseal dysplasia (HP:0100255)4.43100616
5Recurrent gram-negative bacterial infections (HP:0005420)4.29699960
6Recurrent abscess formation (HP:0002722)4.00941562
7Recurrent bacterial skin infections (HP:0005406)3.96637758
8Focal motor seizures (HP:0011153)3.84383576
9Papilledema (HP:0001085)3.67693666
10Volvulus (HP:0002580)3.66609856
11Broad-based gait (HP:0002136)3.47546580
12Long eyelashes (HP:0000527)3.45295779
13Papillary thyroid carcinoma (HP:0002895)3.39069418
14Chronic obstructive pulmonary disease (HP:0006510)3.09771157
15Obstructive lung disease (HP:0006536)3.09771157
16IgM deficiency (HP:0002850)3.08193287
17Slow saccadic eye movements (HP:0000514)3.04795939
18Abnormality of the phalanges of the 2nd finger (HP:0009541)2.99875078
19Gingival bleeding (HP:0000225)2.98365681
20Joint hemorrhage (HP:0005261)2.93219024
21Agitation (HP:0000713)2.89776320
22Epileptic encephalopathy (HP:0200134)2.86511810
23Recurrent skin infections (HP:0001581)2.81285040
24Chromsome breakage (HP:0040012)2.79551044
25Generalized hypopigmentation of hair (HP:0011358)2.71754008
26Acute myeloid leukemia (HP:0004808)2.71290733
27Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.70405342
28Short middle phalanx of the 5th finger (HP:0004220)2.69076144
29Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67997096
30Mediastinal lymphadenopathy (HP:0100721)2.65267568
31Recurrent cutaneous fungal infections (HP:0011370)2.61813853
32Chronic mucocutaneous candidiasis (HP:0002728)2.61813853
33Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.58562474
34Distal lower limb amyotrophy (HP:0008944)2.57464297
35Prostate neoplasm (HP:0100787)2.56668661
36Decreased central vision (HP:0007663)2.54581705
37Recurrent fungal infections (HP:0002841)2.53512021
38Thyroid carcinoma (HP:0002890)2.53327010
39Central scotoma (HP:0000603)2.51756498
40Cheilitis (HP:0100825)2.48586003
41Amelogenesis imperfecta (HP:0000705)2.47765914
42Gait imbalance (HP:0002141)2.46346431
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46035997
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.46035997
45Prolonged bleeding time (HP:0003010)2.45568173
46Elfin facies (HP:0004428)2.45097411
47Abnormality of the intervertebral disk (HP:0005108)2.44307142
48Hip dysplasia (HP:0001385)2.44062175
49Limb hypertonia (HP:0002509)2.44043998
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.43106474
51Coronal craniosynostosis (HP:0004440)2.42245287
52Abnormality of macular pigmentation (HP:0008002)2.41968192
53Hypochromic anemia (HP:0001931)2.40413782
54Nephrogenic diabetes insipidus (HP:0009806)2.40053488
55Abnormality of the corticospinal tract (HP:0002492)2.39513975
56Obsessive-compulsive behavior (HP:0000722)2.39031282
57Gingivitis (HP:0000230)2.37803037
58Congenital primary aphakia (HP:0007707)2.37617669
59Septo-optic dysplasia (HP:0100842)2.37353086
60Lower limb amyotrophy (HP:0007210)2.35725213
61Medial flaring of the eyebrow (HP:0010747)2.33972123
62Thickened helices (HP:0000391)2.33512909
63Neonatal respiratory distress (HP:0002643)2.30158297
64Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.28702078
65Genital tract atresia (HP:0001827)2.26283779
66Progressive hearing impairment (HP:0001730)2.25621953
67Epiphyseal dysplasia (HP:0002656)2.24593080
68Hyperventilation (HP:0002883)2.23487983
69Abnormality of the phalanges of the 5th finger (HP:0004213)2.21529853
70Abnormality of chromosome stability (HP:0003220)2.21346115
71Cortical dysplasia (HP:0002539)2.20962598
72Abnormality of the labia minora (HP:0012880)2.19933032
73Aplasia cutis congenita (HP:0001057)2.18303642
74Ankyloglossia (HP:0010296)2.17322755
75Fair hair (HP:0002286)2.14533880
76Meningitis (HP:0001287)2.11427517
77Vaginal atresia (HP:0000148)2.08388710
78Impaired vibration sensation in the lower limbs (HP:0002166)2.06711933
79Hyperglycinemia (HP:0002154)2.06053806
80Scotoma (HP:0000575)2.05447249
81Inappropriate behavior (HP:0000719)2.05113226
82Recurrent pneumonia (HP:0006532)2.02261080
83Hypoglycemic seizures (HP:0002173)2.02249378
84Prominent nose (HP:0000448)2.02038456
85Abnormal platelet volume (HP:0011876)2.01961257
86Abnormality of the fingertips (HP:0001211)2.01805496
87Protruding tongue (HP:0010808)2.01706531
88Submucous cleft hard palate (HP:0000176)2.00287406
89Retrobulbar optic neuritis (HP:0100654)1.99534296
90Optic neuritis (HP:0100653)1.99534296
91Brushfield spots (HP:0001088)1.99509786
92Small hand (HP:0200055)1.99111621
93Spontaneous hematomas (HP:0007420)1.99058272
94Optic nerve hypoplasia (HP:0000609)1.98865502
95Abnormal lung lobation (HP:0002101)1.98235397
96Widely spaced teeth (HP:0000687)1.96743130
97Dyschromatopsia (HP:0007641)1.96729297
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.96170857
99Thick eyebrow (HP:0000574)1.95961220
100Meckel diverticulum (HP:0002245)1.95584547
101Menorrhagia (HP:0000132)1.95118721
102Short foot (HP:0001773)1.94814509
103Supernumerary spleens (HP:0009799)1.94687041
104Urinary urgency (HP:0000012)1.92521161
105Abnormality of the prostate (HP:0008775)1.91506099
106Chest pain (HP:0100749)1.91264594
107Vasculitis (HP:0002633)1.90521822
108Long clavicles (HP:0000890)1.89923735
109Abnormality of the pubic bones (HP:0003172)1.89877012
110Absent frontal sinuses (HP:0002688)1.88211397
111Abnormality of the columella (HP:0009929)1.86428212
112Tented upper lip vermilion (HP:0010804)1.84206284
113Hypoplastic pelvis (HP:0008839)1.84113513
114Abnormality of the ileum (HP:0001549)1.83647090
115Curly hair (HP:0002212)1.81764491
116Medulloblastoma (HP:0002885)1.81200893
117Poor coordination (HP:0002370)1.80857258
118Atonic seizures (HP:0010819)1.80779734
119Myositis (HP:0100614)1.80462206
120Abnormality of lateral ventricle (HP:0030047)1.80354161
121Abnormality of incisor morphology (HP:0011063)1.80007905
122Heterotopia (HP:0002282)1.79957518
123Aplasia/hypoplasia of the humerus (HP:0006507)1.79853248
124Congenital sensorineural hearing impairment (HP:0008527)1.79408505
125Renovascular hypertension (HP:0100817)1.79042901
126Blue irides (HP:0000635)1.77690704
127Thickened nuchal skin fold (HP:0000474)1.77124581
128Short humerus (HP:0005792)1.76614215
129Cupped ear (HP:0000378)1.76166729
130Cystic hygroma (HP:0000476)1.75180044
131Sloping forehead (HP:0000340)1.74262710
132Focal seizures (HP:0007359)1.74000103
133White forelock (HP:0002211)1.72966395
134Cellulitis (HP:0100658)1.72753975
135Abnormality of the endocardium (HP:0004306)1.71885209
136Arterial thrombosis (HP:0004420)1.70770459
137Lip pit (HP:0100267)1.70698716
138Neonatal hypoglycemia (HP:0001998)1.70474976
139Rimmed vacuoles (HP:0003805)1.70366376
140Generalized tonic-clonic seizures (HP:0002069)1.69920899
141Patchy hypopigmentation of hair (HP:0011365)1.69205157
142Shoulder girdle muscle weakness (HP:0003547)1.68880866
143Delayed myelination (HP:0012448)1.68379379
144Petechiae (HP:0000967)1.67749238
145Abnormal epiphyseal ossification (HP:0010656)1.67185130
146Epiphyseal stippling (HP:0010655)1.66805149
147Abnormality of DNA repair (HP:0003254)1.66674860
148Rhabdomyosarcoma (HP:0002859)1.66215297
149Genetic anticipation (HP:0003743)1.65447557
150Exotropia (HP:0000577)1.65097062
151Triphalangeal thumb (HP:0001199)1.65023899
152Excessive salivation (HP:0003781)1.64047070
153Drooling (HP:0002307)1.64047070
154Tapered finger (HP:0001182)1.62543893
155Increased nuchal translucency (HP:0010880)1.62500549
156Absent speech (HP:0001344)1.62381296
157Colon cancer (HP:0003003)1.61370677
158Intestinal atresia (HP:0011100)1.61370330
159Absent eyebrow (HP:0002223)1.61335320
160Underdeveloped supraorbital ridges (HP:0009891)1.60920935
161Abnormality of the metopic suture (HP:0005556)1.60264930
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.59497689
163Abnormality of the 2nd finger (HP:0004100)1.59169722
164Overlapping toe (HP:0001845)1.58288789
165Specific learning disability (HP:0001328)1.56631451
166Clonus (HP:0002169)1.55920763
167Broad foot (HP:0001769)1.54213392
168Dysdiadochokinesis (HP:0002075)1.53288301
169Absent radius (HP:0003974)1.52524899
170Aplasia involving forearm bones (HP:0009822)1.52266347
171Absent forearm bone (HP:0003953)1.52266347
172Postaxial hand polydactyly (HP:0001162)1.50808673
173Duodenal stenosis (HP:0100867)1.49475163
174Small intestinal stenosis (HP:0012848)1.49475163
175Myelodysplasia (HP:0002863)1.47861511
176Abnormality of the costochondral junction (HP:0000919)1.46043724
177Prominent metopic ridge (HP:0005487)1.45615397
178Tubulointerstitial nephritis (HP:0001970)1.45583364
179Glioma (HP:0009733)1.44563546
180Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.44281046
181Facial hemangioma (HP:0000329)1.44188039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK86.64170235
2SIK23.34624874
3SIK32.99958970
4CDK122.88116553
5BCR2.81980446
6MAP3K42.73891863
7CASK2.70018923
8IRAK42.56096822
9MKNK22.42852310
10INSRR2.23973455
11TEC2.16972072
12TSSK62.15730667
13TAF12.13428406
14FES2.04705838
15BRD42.03736463
16NTRK32.02365351
17TXK1.92468713
18EIF2AK31.90542123
19MAPK111.90344911
20TNK21.87247280
21CAMK1G1.85626059
22PLK41.83378019
23CAMK1D1.80826203
24CDC71.80547038
25TRIM281.76402693
26PNCK1.74159750
27TNIK1.73679327
28MAP3K141.73036707
29RIPK41.70971819
30TESK11.67121156
31WNK31.65830817
32MKNK11.54051133
33TAOK31.53646442
34NTRK21.49113922
35EPHA41.48830131
36CSNK1G21.44495267
37MAP2K41.44092993
38ZAK1.40107873
39NEK11.35814361
40EIF2AK21.34427671
41PLK31.33054329
42BRAF1.28950820
43PINK11.28143887
44BTK1.27650346
45DYRK31.24456659
46RPS6KA41.23500005
47CLK11.20956724
48LIMK11.20464363
49WEE11.20410545
50CSNK1G11.19723193
51PBK1.18515729
52CDK191.18280820
53MINK11.16529219
54ATR1.13823819
55CDK71.13024765
56PLK21.11769655
57PASK1.10355611
58STK38L1.05956306
59LYN1.03934968
60SIK11.02647400
61ALK1.01667805
62CSNK1G31.00812686
63TTK1.00416622
64KSR10.97821446
65PRKD30.97642748
66STK30.97608326
67CSNK1A1L0.97416927
68EPHB20.97027448
69SYK0.96336270
70PRPF4B0.95735254
71ERBB30.95577039
72CHEK20.95329255
73BUB10.93139190
74FLT30.92921127
75BRSK20.92886547
76MAPK130.92517148
77TGFBR10.92259727
78ITK0.90828833
79CAMK40.90142795
80CSF1R0.89672721
81DYRK20.89340021
82MAP3K130.89152008
83RIPK10.83704190
84PIK3CA0.83321187
85EGFR0.81927694
86LATS20.77530805
87BLK0.77497697
88MAP2K70.77070925
89KIT0.74413777
90HCK0.74223131
91VRK10.73153864
92ACVR1B0.72073932
93PRKCQ0.71951354
94STK390.71847169
95STK240.70946040
96SGK20.70582608
97JAK10.69260290
98PLK10.68794154
99FGFR10.68446162
100YES10.67412297
101PRKCG0.67371845
102PIK3CG0.67225515
103EIF2AK10.67102021
104LATS10.66565168
105NUAK10.66287724
106MARK10.66104158
107MARK30.65848731
108LCK0.65777374
109BMPR1B0.63730742
110WNK40.62209294
111CDK140.60972243
112MAPK40.60598578
113WNK10.60362413
114SGK10.59916132
115MAP3K120.59119596
116CDK50.59026713
117PRKAA20.58583739
118CHEK10.58443847
119CSNK1E0.57327204
120TRPM70.57241617
121MAP3K20.57230401
122MAP3K60.56946221
123CDK180.56601067
124CAMK10.54440649
125BMPR20.54324061
126PKN10.54099640
127CDK40.52337387
128CAMKK20.51451677
129FGR0.51324627
130NEK60.51076173
131CDK150.49993874
132SGK30.48893490
133IGF1R0.47843267
134CDK60.47644474
135CDK11A0.47155872
136MAP4K20.44622208
137UHMK10.44581366
138AKT30.44527184
139CAMK2A0.43941627
140PRKCB0.43692958
141MAPK100.42759400
142PRKCH0.42191319
143PRKG10.41238138
144CSNK1D0.41048567
145CCNB10.40178627
146CDK20.39003522
147FRK0.38976323
148MAPK140.38974697
149SRPK10.38062448
150PIM10.35809023
151FYN0.34708155
152SRC0.34309220
153SGK4940.33669977
154SGK2230.33669977
155ERBB20.32424185
156MAP4K10.32082131
157BMX0.32044470
158NEK20.31619948
159DYRK1A0.31533069
160RPS6KA30.31283295
161CDK30.31080227
162PRKCE0.28565307
163TESK20.27821525
164ATM0.27428054
165GSK3B0.26929194
166PRKACB0.26565247
167PRKDC0.25779254

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.42839705
2Nicotine addiction_Homo sapiens_hsa050332.78537847
3Systemic lupus erythematosus_Homo sapiens_hsa053222.39172136
4RNA transport_Homo sapiens_hsa030132.00292770
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.99936332
6Morphine addiction_Homo sapiens_hsa050321.91916531
7Glioma_Homo sapiens_hsa052141.90989042
8mRNA surveillance pathway_Homo sapiens_hsa030151.89434537
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88216161
10Hematopoietic cell lineage_Homo sapiens_hsa046401.85393008
11RNA degradation_Homo sapiens_hsa030181.77335783
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.73814773
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.73799792
14Fanconi anemia pathway_Homo sapiens_hsa034601.72613618
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.71963902
16Selenocompound metabolism_Homo sapiens_hsa004501.70630438
17Non-small cell lung cancer_Homo sapiens_hsa052231.69537897
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68307950
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66096054
20Circadian entrainment_Homo sapiens_hsa047131.64549752
21Cell cycle_Homo sapiens_hsa041101.60497206
22Steroid biosynthesis_Homo sapiens_hsa001001.60377503
23Leishmaniasis_Homo sapiens_hsa051401.57986666
24Spliceosome_Homo sapiens_hsa030401.56744438
25Glutamatergic synapse_Homo sapiens_hsa047241.54676264
26Protein export_Homo sapiens_hsa030601.53026513
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47887446
28Nucleotide excision repair_Homo sapiens_hsa034201.46978290
29Prostate cancer_Homo sapiens_hsa052151.45992843
30Staphylococcus aureus infection_Homo sapiens_hsa051501.41103177
31Mismatch repair_Homo sapiens_hsa034301.40751818
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.39533861
33DNA replication_Homo sapiens_hsa030301.39298194
34Homologous recombination_Homo sapiens_hsa034401.39159598
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37823700
36Olfactory transduction_Homo sapiens_hsa047401.33435198
37Phagosome_Homo sapiens_hsa041451.33098171
38GABAergic synapse_Homo sapiens_hsa047271.32920759
39Alcoholism_Homo sapiens_hsa050341.29637755
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28702672
41Long-term depression_Homo sapiens_hsa047301.27756181
42Serotonergic synapse_Homo sapiens_hsa047261.27535413
43Osteoclast differentiation_Homo sapiens_hsa043801.25796661
44Lysine degradation_Homo sapiens_hsa003101.25274691
45Taste transduction_Homo sapiens_hsa047421.24359412
46Base excision repair_Homo sapiens_hsa034101.24149939
47Sulfur metabolism_Homo sapiens_hsa009201.23688397
48Melanoma_Homo sapiens_hsa052181.22558099
49Oocyte meiosis_Homo sapiens_hsa041141.22323453
50p53 signaling pathway_Homo sapiens_hsa041151.21216201
51Type II diabetes mellitus_Homo sapiens_hsa049301.19407767
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18078995
53Ovarian steroidogenesis_Homo sapiens_hsa049131.17631832
54Phototransduction_Homo sapiens_hsa047441.16877104
55Chronic myeloid leukemia_Homo sapiens_hsa052201.14646585
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11523622
57Cholinergic synapse_Homo sapiens_hsa047251.10080803
58Hedgehog signaling pathway_Homo sapiens_hsa043401.08189322
59Chemokine signaling pathway_Homo sapiens_hsa040621.06587488
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06395969
61Long-term potentiation_Homo sapiens_hsa047201.06321653
62Pancreatic cancer_Homo sapiens_hsa052121.06133255
63Axon guidance_Homo sapiens_hsa043601.04358757
64Renin secretion_Homo sapiens_hsa049241.04270987
65Propanoate metabolism_Homo sapiens_hsa006401.00980961
66Hippo signaling pathway_Homo sapiens_hsa043901.00029713
67Platelet activation_Homo sapiens_hsa046110.99585656
68B cell receptor signaling pathway_Homo sapiens_hsa046620.99304371
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95177340
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94912516
71Salivary secretion_Homo sapiens_hsa049700.94694688
72African trypanosomiasis_Homo sapiens_hsa051430.94624394
73Inositol phosphate metabolism_Homo sapiens_hsa005620.92714946
74Calcium signaling pathway_Homo sapiens_hsa040200.92419261
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90373232
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90234276
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89894373
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89845237
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89598758
80Basal transcription factors_Homo sapiens_hsa030220.87681226
81Thyroid cancer_Homo sapiens_hsa052160.87615179
82cAMP signaling pathway_Homo sapiens_hsa040240.84799537
83Estrogen signaling pathway_Homo sapiens_hsa049150.84730819
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84548599
85Cocaine addiction_Homo sapiens_hsa050300.83726277
86Fatty acid biosynthesis_Homo sapiens_hsa000610.83004516
87Tuberculosis_Homo sapiens_hsa051520.81963244
88Pertussis_Homo sapiens_hsa051330.80954309
89Graft-versus-host disease_Homo sapiens_hsa053320.80280980
90TGF-beta signaling pathway_Homo sapiens_hsa043500.79824022
91MicroRNAs in cancer_Homo sapiens_hsa052060.77845819
92Purine metabolism_Homo sapiens_hsa002300.77559802
93Hepatitis B_Homo sapiens_hsa051610.76733645
94ErbB signaling pathway_Homo sapiens_hsa040120.76336830
95Insulin secretion_Homo sapiens_hsa049110.75943987
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74826323
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74524714
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74038358
99Butanoate metabolism_Homo sapiens_hsa006500.73701267
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.73564712
101Oxytocin signaling pathway_Homo sapiens_hsa049210.72472560
102Dorso-ventral axis formation_Homo sapiens_hsa043200.71916144
103Dopaminergic synapse_Homo sapiens_hsa047280.71877570
104Wnt signaling pathway_Homo sapiens_hsa043100.71822838
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71389684
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71192069
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70603220
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70547992
109Amphetamine addiction_Homo sapiens_hsa050310.70069402
110Type I diabetes mellitus_Homo sapiens_hsa049400.69960112
111Colorectal cancer_Homo sapiens_hsa052100.69701939
112TNF signaling pathway_Homo sapiens_hsa046680.69450689
113Pyrimidine metabolism_Homo sapiens_hsa002400.69081605
114ABC transporters_Homo sapiens_hsa020100.68619691
115Measles_Homo sapiens_hsa051620.68394943
116Basal cell carcinoma_Homo sapiens_hsa052170.67997893
117Thyroid hormone synthesis_Homo sapiens_hsa049180.67637088
118Rheumatoid arthritis_Homo sapiens_hsa053230.67226120
119Sphingolipid metabolism_Homo sapiens_hsa006000.65946773
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65380259
121Small cell lung cancer_Homo sapiens_hsa052220.65321678
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65290507
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64550007
124Folate biosynthesis_Homo sapiens_hsa007900.64535763
125Synaptic vesicle cycle_Homo sapiens_hsa047210.63521200
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62896859
127Allograft rejection_Homo sapiens_hsa053300.62888774
128Amoebiasis_Homo sapiens_hsa051460.61811282
129Circadian rhythm_Homo sapiens_hsa047100.61684703
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60911930
131Gastric acid secretion_Homo sapiens_hsa049710.60328393
132One carbon pool by folate_Homo sapiens_hsa006700.60241659
133RNA polymerase_Homo sapiens_hsa030200.59235464
134Melanogenesis_Homo sapiens_hsa049160.59231743
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58525761
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.57724325
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.57570920
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57118503
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56425362
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55863279
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55735322
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54685484
143Ribosome_Homo sapiens_hsa030100.54415789
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53392209
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53371306
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.52867347
147Huntingtons disease_Homo sapiens_hsa050160.52484265
148Gap junction_Homo sapiens_hsa045400.51691420
149T cell receptor signaling pathway_Homo sapiens_hsa046600.51055127
150Ras signaling pathway_Homo sapiens_hsa040140.50580589
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48838535
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48247866
153MAPK signaling pathway_Homo sapiens_hsa040100.48024141
154Complement and coagulation cascades_Homo sapiens_hsa046100.47535494
155Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47356301
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.47187184
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44952644
158Tight junction_Homo sapiens_hsa045300.42254757
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40382826
160Regulation of autophagy_Homo sapiens_hsa041400.38860140
161Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35789374
162Renal cell carcinoma_Homo sapiens_hsa052110.35322173
163Ether lipid metabolism_Homo sapiens_hsa005650.35101388

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