PAPSS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.84507492
2Golgi transport vesicle coating (GO:0048200)6.84507492
3L-phenylalanine catabolic process (GO:0006559)5.24534918
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.24534918
5COPII vesicle coating (GO:0048208)5.18043078
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.91458451
7L-phenylalanine metabolic process (GO:0006558)4.91458451
8endocrine pancreas development (GO:0031018)4.85688624
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.78591205
10intestinal absorption (GO:0050892)4.60413847
11intestinal cholesterol absorption (GO:0030299)4.57861123
12peptide hormone processing (GO:0016486)4.46175869
13aromatic amino acid family catabolic process (GO:0009074)4.35100411
14protein retention in ER lumen (GO:0006621)4.34389026
15cellular glucuronidation (GO:0052695)4.20857627
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.11044942
17glucocorticoid biosynthetic process (GO:0006704)4.04831161
18uronic acid metabolic process (GO:0006063)4.01061915
19glucuronate metabolic process (GO:0019585)4.01061915
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95468759
21sulfur amino acid catabolic process (GO:0000098)3.93108017
22regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.83088697
23macroautophagy (GO:0016236)3.81717433
24drug transmembrane transport (GO:0006855)3.81499167
25UDP-N-acetylglucosamine metabolic process (GO:0006047)3.79898516
26signal peptide processing (GO:0006465)3.70741607
27regulation of extracellular matrix disassembly (GO:0010715)3.70657392
28regulation of cholesterol homeostasis (GO:2000188)3.66982511
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.66336714
30sequestering of extracellular ligand from receptor (GO:0035581)3.65699584
31drug catabolic process (GO:0042737)3.65489801
32cysteine metabolic process (GO:0006534)3.64967965
33high-density lipoprotein particle remodeling (GO:0034375)3.63143530
34tryptophan metabolic process (GO:0006568)3.58792597
35triglyceride homeostasis (GO:0070328)3.58780421
36acylglycerol homeostasis (GO:0055090)3.58780421
37regulation of type B pancreatic cell apoptotic process (GO:2000674)3.58570545
38glyoxylate metabolic process (GO:0046487)3.58001907
39homocysteine metabolic process (GO:0050667)3.55046606
40indole-containing compound catabolic process (GO:0042436)3.54471879
41indolalkylamine catabolic process (GO:0046218)3.54471879
42tryptophan catabolic process (GO:0006569)3.54471879
43C21-steroid hormone biosynthetic process (GO:0006700)3.53850966
44regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.51132293
45activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.50255472
46alpha-linolenic acid metabolic process (GO:0036109)3.48070819
47lysine metabolic process (GO:0006553)3.45704126
48lysine catabolic process (GO:0006554)3.45704126
49Leydig cell differentiation (GO:0033327)3.44119474
50hormone catabolic process (GO:0042447)3.43192790
51glandular epithelial cell differentiation (GO:0002067)3.43169763
52positive regulation of glycolytic process (GO:0045821)3.41954627
53reverse cholesterol transport (GO:0043691)3.39870355
54phospholipid efflux (GO:0033700)3.39484733
55exocrine pancreas development (GO:0031017)3.37977803
56tyrosine metabolic process (GO:0006570)3.35299299
57peptidyl-glutamic acid carboxylation (GO:0017187)3.34129177
58protein carboxylation (GO:0018214)3.34129177
59regulation of cholesterol esterification (GO:0010872)3.33435985
604-hydroxyproline metabolic process (GO:0019471)3.33328545
61vesicle coating (GO:0006901)3.32381354
62bile acid and bile salt transport (GO:0015721)3.32242538
63bile acid biosynthetic process (GO:0006699)3.30140708
64positive regulation of nuclease activity (GO:0032075)3.29423069
65urea cycle (GO:0000050)3.28341574
66urea metabolic process (GO:0019627)3.28341574
67protein maturation by protein folding (GO:0022417)3.27525082
68flavonoid metabolic process (GO:0009812)3.27471075
69kynurenine metabolic process (GO:0070189)3.27453447
70bile acid metabolic process (GO:0008206)3.27421342
71negative regulation of complement activation (GO:0045916)3.24518003
72androgen biosynthetic process (GO:0006702)3.18851719
73glucocorticoid metabolic process (GO:0008211)3.18591378
74aromatic amino acid family metabolic process (GO:0009072)3.18033208
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.17907461
76lipoprotein metabolic process (GO:0042157)3.17061467
77cell adhesion mediated by integrin (GO:0033627)3.14660665
78drug transport (GO:0015893)3.14466941
79regulation of transforming growth factor beta1 production (GO:0032908)3.12121760
80plasma lipoprotein particle remodeling (GO:0034369)3.11635045
81protein-lipid complex remodeling (GO:0034368)3.11635045
82macromolecular complex remodeling (GO:0034367)3.11635045
83type B pancreatic cell development (GO:0003323)3.09830263
84regulation of bile acid biosynthetic process (GO:0070857)3.09613576
85adhesion of symbiont to host (GO:0044406)3.08450253
86toxin metabolic process (GO:0009404)3.06634130
87cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.06132343
88sphingomyelin metabolic process (GO:0006684)3.05123433
89endoplasmic reticulum unfolded protein response (GO:0030968)3.04694689
90negative regulation of protein activation cascade (GO:2000258)3.04166542
91sequestering of metal ion (GO:0051238)3.03314744
92cholesterol efflux (GO:0033344)3.02918632
93nitrogen cycle metabolic process (GO:0071941)3.02865279
94tricarboxylic acid metabolic process (GO:0072350)3.01974928
95cellular modified amino acid catabolic process (GO:0042219)3.00690183
96drug metabolic process (GO:0017144)2.99181058
97positive regulation of fatty acid biosynthetic process (GO:0045723)2.98535193
98cellular response to unfolded protein (GO:0034620)2.98280019
99benzene-containing compound metabolic process (GO:0042537)2.98080584
100negative regulation of cholesterol transport (GO:0032375)2.97811634
101negative regulation of sterol transport (GO:0032372)2.97811634
102progesterone metabolic process (GO:0042448)2.97202950
103regulation of nuclease activity (GO:0032069)2.96581007
104cellular ketone body metabolic process (GO:0046950)2.96247789
105regulation of cholesterol biosynthetic process (GO:0045540)2.95676430
106skin morphogenesis (GO:0043589)2.95192683
107indolalkylamine metabolic process (GO:0006586)2.94025601
108amino-acid betaine metabolic process (GO:0006577)2.93666224
109negative regulation of hormone metabolic process (GO:0032351)2.93481270
110virion attachment to host cell (GO:0019062)2.93201100
111adhesion of symbiont to host cell (GO:0044650)2.93201100
112short-chain fatty acid metabolic process (GO:0046459)2.93178199
113regulation of triglyceride catabolic process (GO:0010896)2.92487483
114cellular response to vitamin D (GO:0071305)2.92155330
115nucleotide-sugar biosynthetic process (GO:0009226)2.91383776
116ER-nucleus signaling pathway (GO:0006984)2.91128895
117ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.89824743
118L-alpha-amino acid transmembrane transport (GO:1902475)2.89768605
119fatty acid beta-oxidation (GO:0006635)2.87366321
120negative regulation of hormone biosynthetic process (GO:0032353)2.86979683
121xenobiotic catabolic process (GO:0042178)2.86330847
122fatty acid oxidation (GO:0019395)2.85881920
123cellular response to topologically incorrect protein (GO:0035967)2.84116107
124glandular epithelial cell development (GO:0002068)2.83022887
125urate metabolic process (GO:0046415)2.82651109
126positive regulation of hormone biosynthetic process (GO:0046886)2.79986212
127epoxygenase P450 pathway (GO:0019373)2.75717974
128auditory receptor cell differentiation (GO:0042491)2.74105175
129regulation of steroid hormone biosynthetic process (GO:0090030)2.69322645
130cellular response to vitamin (GO:0071295)2.67858711
131regulation of integrin-mediated signaling pathway (GO:2001044)2.67095865
132keratan sulfate catabolic process (GO:0042340)2.64457055
133regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.63821378
134angiotensin maturation (GO:0002003)2.60119752
135positive regulation of calcium ion import (GO:0090280)2.58511240
136desmosome organization (GO:0002934)2.56696517
137regulation of fibrinolysis (GO:0051917)2.54286899
138cellular response to cadmium ion (GO:0071276)2.53306899
139positive regulation of actin filament depolymerization (GO:0030836)2.51246942
140response to follicle-stimulating hormone (GO:0032354)2.50609238
141extracellular negative regulation of signal transduction (GO:1900116)2.49005781
142extracellular regulation of signal transduction (GO:1900115)2.49005781
143vitamin D metabolic process (GO:0042359)2.47487714
144type B pancreatic cell proliferation (GO:0044342)2.46090283
145chondrocyte proliferation (GO:0035988)2.44289660
146glomerular basement membrane development (GO:0032836)2.43883807
147transcytosis (GO:0045056)2.43424651
148collagen fibril organization (GO:0030199)2.42885093
149cellular response to antibiotic (GO:0071236)2.41663065
150insulin secretion (GO:0030073)2.40663710
151wound healing, spreading of epidermal cells (GO:0035313)2.39975467
152positive regulation of protein autophosphorylation (GO:0031954)2.39657201
153sphingolipid catabolic process (GO:0030149)2.39464790
154oligosaccharide catabolic process (GO:0009313)2.39167940
155cellular zinc ion homeostasis (GO:0006882)2.37431891
156positive regulation of macroautophagy (GO:0016239)2.33053699
157androgen metabolic process (GO:0008209)2.32941756
158regulation of glucocorticoid metabolic process (GO:0031943)2.32923064
159membrane lipid catabolic process (GO:0046466)2.30874380
160C21-steroid hormone metabolic process (GO:0008207)2.30695036
161positive regulation of steroid biosynthetic process (GO:0010893)2.30286423
162ethanol oxidation (GO:0006069)2.28624724
163smooth muscle tissue development (GO:0048745)2.28308396
164phenylpropanoid metabolic process (GO:0009698)2.28001281
165nitric oxide biosynthetic process (GO:0006809)2.27760730
166omega-hydroxylase P450 pathway (GO:0097267)2.25739080
167epithelial cell fate commitment (GO:0072148)2.24639245
168regulation of plasminogen activation (GO:0010755)2.20279097
169positive regulation of nitric-oxide synthase activity (GO:0051000)2.20069883
170regulation of metalloenzyme activity (GO:0048552)2.19390868
171positive regulation of hormone metabolic process (GO:0032352)2.18808005
172positive regulation of steroid metabolic process (GO:0045940)2.18454544
173regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17819370
174negative regulation of humoral immune response (GO:0002921)2.17731616
175cellular response to gonadotropin stimulus (GO:0071371)2.16223857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.69911209
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.10514186
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.13181146
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.10468857
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.15274483
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.84640744
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.67461792
8GATA1_22025678_ChIP-Seq_K562_Human3.62944148
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.32764702
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.19585815
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.82645437
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61256481
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.47024490
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.44230678
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.35731989
16CLOCK_20551151_ChIP-Seq_293T_Human1.98847429
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96080876
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95639526
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93726437
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.89125164
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.88966648
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.82832929
23BRD4_25478319_ChIP-Seq_HGPS_Human1.81289036
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77677876
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.77545115
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71173400
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.71028571
28GATA4_25053715_ChIP-Seq_YYC3_Human1.62530744
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.60457637
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53764515
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51585738
32* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51056961
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.50301651
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48196471
35CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47498053
36* SOX2_20726797_ChIP-Seq_SW620_Human1.44533698
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.43403212
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41285290
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37370139
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37287463
41TP53_18474530_ChIP-ChIP_U2OS_Human1.34821626
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30261792
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.29342343
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.27492784
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27275786
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.25177765
47FOXA1_25552417_ChIP-Seq_VCAP_Human1.21933076
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21294575
49AHR_22903824_ChIP-Seq_MCF-7_Human1.20507311
50* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19942976
51JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19832129
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17927999
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17927999
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17033133
55GATA6_25053715_ChIP-Seq_YYC3_Human1.15911283
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14217555
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14217555
58JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13905118
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.13360505
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.12405287
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09873819
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09504784
63GATA3_24758297_ChIP-Seq_MCF-7_Human1.08437295
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07054600
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06304702
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05909719
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03863481
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03464696
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00557231
70FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00471926
71SMAD4_21799915_ChIP-Seq_A2780_Human0.99455151
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99398235
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98709200
74SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97984823
75PIAS1_25552417_ChIP-Seq_VCAP_Human0.95543405
76* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94560688
77GBX2_23144817_ChIP-Seq_PC3_Human0.94557453
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93973292
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93919958
80FOXO3_23340844_ChIP-Seq_DLD1_Human0.93758861
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92343511
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92326942
83SMAD3_21741376_ChIP-Seq_HESCs_Human0.92165793
84HTT_18923047_ChIP-ChIP_STHdh_Human0.90946819
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89552690
86NANOG_18555785_Chip-Seq_ESCs_Mouse0.89433876
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88748852
88MTF2_20144788_ChIP-Seq_MESCs_Mouse0.88319510
89WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87655921
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87519208
91NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87456410
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86307857
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86259575
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86213780
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86012544
96GATA1_19941826_ChIP-Seq_K562_Human0.85403314
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.84975538
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84950201
99AR_20517297_ChIP-Seq_VCAP_Human0.84729896
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84528048
101ERG_20517297_ChIP-Seq_VCAP_Human0.83743098
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81577293
103BCAT_22108803_ChIP-Seq_LS180_Human0.81306796
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81190879
105EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79958449
106* TP63_23658742_ChIP-Seq_EP156T_Human0.78219666
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77681496
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.76796870
109* CDX2_22108803_ChIP-Seq_LS180_Human0.75151574
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.74563591
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.74563591
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73931269
113GATA2_19941826_ChIP-Seq_K562_Human0.71073968
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69464380
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69343880
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68848631
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.68380781
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.68245247
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68190571
120* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67174771
121* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.66877947
122* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66835482
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66448504
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65241967
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64712143
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63437017
127CJUN_26792858_Chip-Seq_BT549_Human0.63228267
128* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62730026
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61262722
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.59522715
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.57603955
132* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.57448700
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.56107776
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55140886
135TCF4_22108803_ChIP-Seq_LS180_Human0.54492071
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.52567184
137RXR_22108803_ChIP-Seq_LS180_Human0.52345493
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.52221315
139* CBP_21632823_ChIP-Seq_H3396_Human0.52083704
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.51878286
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.51583719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.94150057
2MP0005360_urolithiasis5.63828392
3MP0008438_abnormal_cutaneous_collagen5.19534627
4MP0005365_abnormal_bile_salt4.53218156
5MP0005085_abnormal_gallbladder_physiolo4.25582299
6MP0003195_calcinosis3.90154627
7MP0008875_abnormal_xenobiotic_pharmacok3.76606757
8MP0004043_abnormal_pH_regulation3.59882396
9MP0003252_abnormal_bile_duct3.58666377
10MP0003283_abnormal_digestive_organ3.47481437
11MP0002877_abnormal_melanocyte_morpholog3.09796973
12MP0010352_gastrointestinal_tract_polyps3.07486789
13MP0001666_abnormal_nutrient_absorption2.93106736
14MP0004272_abnormal_basement_membrane2.87425272
15MP0010329_abnormal_lipoprotein_level2.48891354
16MP0003279_aneurysm2.47501886
17MP0003806_abnormal_nucleotide_metabolis2.46664973
18MP0002909_abnormal_adrenal_gland2.46127845
19MP0002693_abnormal_pancreas_physiology2.44941388
20MP0009840_abnormal_foam_cell2.39522254
21MP0010368_abnormal_lymphatic_system2.38755764
22MP0001944_abnormal_pancreas_morphology2.30676002
23MP0005275_abnormal_skin_tensile2.28481711
24MP0004264_abnormal_extraembryonic_tissu2.18432654
25MP0003183_abnormal_peptide_metabolism2.17680459
26MP0005503_abnormal_tendon_morphology2.16995299
27MP0005220_abnormal_exocrine_pancreas2.16179859
28MP0001958_emphysema2.14627124
29MP0005332_abnormal_amino_acid2.13255424
30MP0002138_abnormal_hepatobiliary_system2.09677314
31MP0009643_abnormal_urine_homeostasis2.05552465
32MP0000678_abnormal_parathyroid_gland1.98512907
33MP0003868_abnormal_feces_composition1.96880742
34MP0005379_endocrine/exocrine_gland_phen1.92579962
35MP0002295_abnormal_pulmonary_circulatio1.85546532
36MP0002078_abnormal_glucose_homeostasis1.78696087
37MP0010386_abnormal_urinary_bladder1.78654118
38MP0004019_abnormal_vitamin_homeostasis1.77241109
39MP0002118_abnormal_lipid_homeostasis1.74783798
40MP0003566_abnormal_cell_adhesion1.69276497
41MP0001542_abnormal_bone_strength1.62891642
42MP0000609_abnormal_liver_physiology1.60765194
43MP0003300_gastrointestinal_ulcer1.58510862
44MP0005083_abnormal_biliary_tract1.57672108
45MP0002896_abnormal_bone_mineralization1.49261021
46MP0000013_abnormal_adipose_tissue1.46479316
47MP0001765_abnormal_ion_homeostasis1.41394995
48MP0005636_abnormal_mineral_homeostasis1.39634352
49MP0003941_abnormal_skin_development1.38461987
50MP0001756_abnormal_urination1.36199327
51MP0003091_abnormal_cell_migration1.35411511
52* MP0009780_abnormal_chondrocyte_physiolo1.34850695
53MP0002876_abnormal_thyroid_physiology1.34787069
54MP0005319_abnormal_enzyme/_coenzyme1.33570556
55MP0003950_abnormal_plasma_membrane1.33152091
56MP0005023_abnormal_wound_healing1.30874731
57MP0008004_abnormal_stomach_pH1.29029690
58MP0002928_abnormal_bile_duct1.27842334
59MP0002837_dystrophic_cardiac_calcinosis1.25465927
60MP0003191_abnormal_cellular_cholesterol1.22594585
61MP0002060_abnormal_skin_morphology1.20898224
62MP0001243_abnormal_dermal_layer1.18048529
63MP0005595_abnormal_vascular_smooth1.13729929
64MP0001764_abnormal_homeostasis1.13398927
65MP0003953_abnormal_hormone_level1.13074024
66MP0005058_abnormal_lysosome_morphology1.08469800
67MP0005646_abnormal_pituitary_gland1.07105590
68MP0010234_abnormal_vibrissa_follicle1.04532816
69MP0000538_abnormal_urinary_bladder1.01879777
70MP0001270_distended_abdomen0.98857471
71MP0000613_abnormal_salivary_gland0.98520576
72MP0000767_abnormal_smooth_muscle0.98415385
73MP0005535_abnormal_body_temperature0.96376921
74MP0005164_abnormal_response_to0.95803807
75* MP0009642_abnormal_blood_homeostasis0.93374175
76MP0003045_fibrosis0.92312304
77MP0001879_abnormal_lymphatic_vessel0.92160535
78MP0005623_abnormal_meninges_morphology0.89722044
79MP0005408_hypopigmentation0.89601716
80MP0003879_abnormal_hair_cell0.88504363
81MP0005448_abnormal_energy_balance0.87986759
82MP0005584_abnormal_enzyme/coenzyme_acti0.87890269
83MP0003186_abnormal_redox_activity0.87576162
84MP0008961_abnormal_basal_metabolism0.83557930
85MP0005670_abnormal_white_adipose0.83312702
86MP0005508_abnormal_skeleton_morphology0.83032019
87MP0004510_myositis0.82753728
88MP0000230_abnormal_systemic_arterial0.82292249
89* MP0000163_abnormal_cartilage_morphology0.81885547
90MP0005165_increased_susceptibility_to0.81815880
91MP0005084_abnormal_gallbladder_morpholo0.81671106
92MP0005334_abnormal_fat_pad0.79525875
93MP0005310_abnormal_salivary_gland0.79426807
94MP0000516_abnormal_urinary_system0.78450851
95MP0005367_renal/urinary_system_phenotyp0.78450851
96* MP0000462_abnormal_digestive_system0.77558126
97MP0000598_abnormal_liver_morphology0.77060850
98MP0009697_abnormal_copulation0.76745186
99MP0006082_CNS_inflammation0.74371447
100MP0002136_abnormal_kidney_physiology0.71180073
101MP0003172_abnormal_lysosome_physiology0.70459755
102MP0002998_abnormal_bone_remodeling0.69126244
103MP0000003_abnormal_adipose_tissue0.67672376
104MP0003866_abnormal_defecation0.64663367
105MP0003075_altered_response_to0.63906358
106MP0005248_abnormal_Harderian_gland0.61901979
107MP0003705_abnormal_hypodermis_morpholog0.60494562
108MP0005166_decreased_susceptibility_to0.60460399
109MP0001661_extended_life_span0.58925364
110MP0001501_abnormal_sleep_pattern0.58441864
111MP0000639_abnormal_adrenal_gland0.57855285
112MP0002971_abnormal_brown_adipose0.55539195
113MP0002234_abnormal_pharynx_morphology0.55182712
114MP0008469_abnormal_protein_level0.54967227
115* MP0003795_abnormal_bone_structure0.54755460
116MP0004085_abnormal_heartbeat0.54459878
117MP0005187_abnormal_penis_morphology0.54173083
118MP0002168_other_aberrant_phenotype0.54017052
119MP0009672_abnormal_birth_weight0.54007150
120* MP0002115_abnormal_skeleton_extremities0.53557000
121MP0002254_reproductive_system_inflammat0.53500540
122MP0005257_abnormal_intraocular_pressure0.51131797
123MP0003959_abnormal_lean_body0.50668965
124MP0009384_cardiac_valve_regurgitation0.50540382
125MP0000681_abnormal_thyroid_gland0.48981176
126* MP0005381_digestive/alimentary_phenotyp0.48651873
127MP0004134_abnormal_chest_morphology0.48586915
128MP0005376_homeostasis/metabolism_phenot0.48203731
129MP0003656_abnormal_erythrocyte_physiolo0.47239166
130MP0002098_abnormal_vibrissa_morphology0.46924044
131MP0001664_abnormal_digestion0.46875150
132MP0004782_abnormal_surfactant_physiolog0.46321000
133MP0005266_abnormal_metabolism0.45378801
134MP0009765_abnormal_xenobiotic_induced0.44434294
135MP0005375_adipose_tissue_phenotype0.43365805
136MP0006054_spinal_hemorrhage0.43234934
137MP0002163_abnormal_gland_morphology0.42612849

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)6.00642420
2Hyperinsulinemic hypoglycemia (HP:0000825)5.75914676
3Hypoglycemic seizures (HP:0002173)5.70152829
4Premature rupture of membranes (HP:0001788)5.27450405
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.06765531
6Symptomatic seizures (HP:0011145)5.05656232
7Ketoacidosis (HP:0001993)4.48317734
8Intrahepatic cholestasis (HP:0001406)4.43583704
9Abnormal tarsal ossification (HP:0008369)4.21132384
10Conjugated hyperbilirubinemia (HP:0002908)4.11884444
11Protrusio acetabuli (HP:0003179)4.11205356
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.92342616
13Hyperglycemia (HP:0003074)3.89131954
14Cardiovascular calcification (HP:0011915)3.80214422
15Ketosis (HP:0001946)3.76408511
16Xanthomatosis (HP:0000991)3.76177616
17Generalized aminoaciduria (HP:0002909)3.64846964
18Epiphyseal dysplasia (HP:0002656)3.62801174
19Abnormality of the intrinsic pathway (HP:0010989)3.55119312
20Mitral stenosis (HP:0001718)3.53105110
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.49479425
22Hypobetalipoproteinemia (HP:0003563)3.45825337
23Late onset (HP:0003584)3.43376334
24Insulin-resistant diabetes mellitus (HP:0000831)3.38706054
25Abnormality of endocrine pancreas physiology (HP:0012093)3.37493821
26Abnormality of the pancreatic islet cells (HP:0006476)3.37493821
27Vascular calcification (HP:0004934)3.36731976
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.36521949
29Prolonged partial thromboplastin time (HP:0003645)3.34132124
30Protuberant abdomen (HP:0001538)3.28807160
31Abnormal foot bone ossification (HP:0010675)3.21738441
32Abnormality of the common coagulation pathway (HP:0010990)3.19283989
33Cupped ribs (HP:0000887)3.17225122
34Fat malabsorption (HP:0002630)3.09176419
35Pancreatic islet-cell hyperplasia (HP:0004510)3.06015574
36Deep venous thrombosis (HP:0002625)3.04510096
37Aortic dissection (HP:0002647)3.04504608
38Flat acetabular roof (HP:0003180)2.98589482
39Abnormality of purine metabolism (HP:0004352)2.95223691
40Hyperglycinuria (HP:0003108)2.88010390
41Aortic aneurysm (HP:0004942)2.86849956
42Abdominal distention (HP:0003270)2.85628111
43Enlarged penis (HP:0000040)2.84278301
44Abnormal pancreas size (HP:0012094)2.83178443
45Malnutrition (HP:0004395)2.80227233
46Gout (HP:0001997)2.79561846
47Delayed epiphyseal ossification (HP:0002663)2.73698492
48Hyperactive renin-angiotensin system (HP:0000841)2.71401341
49Vascular tortuosity (HP:0004948)2.69494213
50Cervical subluxation (HP:0003308)2.68875057
51Abnormality of dentin (HP:0010299)2.66794887
52Metaphyseal irregularity (HP:0003025)2.66350158
53Abnormality of proline metabolism (HP:0010907)2.63070802
54Hydroxyprolinuria (HP:0003080)2.63070802
55Epidermoid cyst (HP:0200040)2.59902968
56Hypolipoproteinemia (HP:0010981)2.55623208
57Hypoplastic ischia (HP:0003175)2.54208144
58Wormian bones (HP:0002645)2.52955107
59Hematochezia (HP:0002573)2.51382127
60Increased CSF protein (HP:0002922)2.49582564
61Insulin resistance (HP:0000855)2.48342917
62Soft skin (HP:0000977)2.47052630
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46564382
64Vacuolated lymphocytes (HP:0001922)2.46459896
65Abnormality of vitamin metabolism (HP:0100508)2.43885924
66Vitreoretinal degeneration (HP:0000655)2.43230842
67Abnormality of the ischium (HP:0003174)2.42400405
68Abnormality of liposaccharide metabolism (HP:0010968)2.41918501
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.41918501
70Abnormality of glycolipid metabolism (HP:0010969)2.41918501
71Irregular epiphyses (HP:0010582)2.40775730
72Flat capital femoral epiphysis (HP:0003370)2.40043473
73Abnormality of urine glucose concentration (HP:0011016)2.39209169
74Glycosuria (HP:0003076)2.39209169
75Decreased circulating renin level (HP:0003351)2.39001371
76Abnormality of glycine metabolism (HP:0010895)2.38959907
77Abnormality of serine family amino acid metabolism (HP:0010894)2.38959907
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.37938802
79Metaphyseal cupping (HP:0003021)2.35336942
80Abnormality of nucleobase metabolism (HP:0010932)2.35313383
81Broad metatarsal (HP:0001783)2.35144308
82Hyperammonemia (HP:0001987)2.34836617
83Nuclear cataract (HP:0100018)2.34563840
84Hyperphosphatemia (HP:0002905)2.34404351
85Abnormality of calcium-phosphate metabolism (HP:0100530)2.33869227
86Hyperbilirubinemia (HP:0002904)2.32817670
87Skin nodule (HP:0200036)2.29745898
88Follicular hyperkeratosis (HP:0007502)2.28947927
89Osteomalacia (HP:0002749)2.28927678
90Fragile skin (HP:0001030)2.28038945
91Abnormality of vitamin B metabolism (HP:0004340)2.27292451
92* Urinary glycosaminoglycan excretion (HP:0003541)2.26480557
93* Mucopolysacchariduria (HP:0008155)2.26480557
94Arterial tortuosity (HP:0005116)2.25692491
95* Abnormality of mucopolysaccharide metabolism (HP:0011020)2.24793312
96* Abnormality of polysaccharide metabolism (HP:0011012)2.24793312
97* Abnormality of glycosaminoglycan metabolism (HP:0004371)2.24793312
98Dysostosis multiplex (HP:0000943)2.24583900
99Abnormality of fatty-acid metabolism (HP:0004359)2.24153868
100Hypokalemia (HP:0002900)2.23772848
101Joint hemorrhage (HP:0005261)2.23274532
102Striae distensae (HP:0001065)2.23125047
103Large for gestational age (HP:0001520)2.22784271
104Hyperglycinemia (HP:0002154)2.22439421
105Abnormality of aspartate family amino acid metabolism (HP:0010899)2.22407229
106Vertebral compression fractures (HP:0002953)2.22074494
107Abnormal enzyme/coenzyme activity (HP:0012379)2.21059994
108Osteolytic defects of the hand bones (HP:0009699)2.20846445
109Osteolytic defects of the phalanges of the hand (HP:0009771)2.20846445
110Genu recurvatum (HP:0002816)2.20563692
111Alkalosis (HP:0001948)2.19673232
112Testicular neoplasm (HP:0010788)2.17912350
113Enlarged epiphyses (HP:0010580)2.16861822
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.16792633
115Ovoid vertebral bodies (HP:0003300)2.15761316
116Elevated alkaline phosphatase (HP:0003155)2.15375070
117Abnormality of alkaline phosphatase activity (HP:0004379)2.15130832
118Hyperlipoproteinemia (HP:0010980)2.14302834
119Hypophosphatemia (HP:0002148)2.14039467
120Abnormal sex determination (HP:0012244)2.13534141
121Sex reversal (HP:0012245)2.13534141
122Hyperphosphaturia (HP:0003109)2.12738105
123Ankle contracture (HP:0006466)2.12442455
124Abnormality of chloride homeostasis (HP:0011422)2.11632926
125Spinal rigidity (HP:0003306)2.10785440
126Steatorrhea (HP:0002570)2.10660873
127Long toe (HP:0010511)2.10623184
128Beaking of vertebral bodies (HP:0004568)2.08523195
129Irritability (HP:0000737)2.06795597
130Hypoalphalipoproteinemia (HP:0003233)2.06657583
131Small epiphyses (HP:0010585)2.06219400
132Abnormality of renin-angiotensin system (HP:0000847)2.06111989
133Abnormality of carpal bone ossification (HP:0006257)2.05941758
134Enlarged kidneys (HP:0000105)2.05919011
135Proximal tubulopathy (HP:0000114)2.05831183
136Abnormality of complement system (HP:0005339)2.03841354
137Hyperextensible skin (HP:0000974)2.03576936
138Peritonitis (HP:0002586)2.01184741
139Atrophic scars (HP:0001075)2.00480562
140Metabolic acidosis (HP:0001942)2.00411662
141Progressive neurologic deterioration (HP:0002344)1.99603062
142Tetraparesis (HP:0002273)1.99274534
143Congenital glaucoma (HP:0001087)1.98440577
144Congenital sensorineural hearing impairment (HP:0008527)1.96032733
145Abnormal cartilage morphology (HP:0002763)1.95393832
146Abnormal delivery (HP:0001787)1.94107023
147Cardiomegaly (HP:0001640)1.93639604
148Thin bony cortex (HP:0002753)1.93104810
149Dilatation of the ascending aorta (HP:0005111)1.92286167
150Bladder diverticulum (HP:0000015)1.92015326
151Widely patent fontanelles and sutures (HP:0004492)1.91736146
152J-shaped sella turcica (HP:0002680)1.91572646
153Renal salt wasting (HP:0000127)1.90698430
154Genu varum (HP:0002970)1.90429000
155Acanthocytosis (HP:0001927)1.90413451
156Overgrowth (HP:0001548)1.89927848
157Hypothermia (HP:0002045)1.89558653
158Complement deficiency (HP:0004431)1.89390359
159Hypokalemic alkalosis (HP:0001949)1.88831500
160Limb hypertonia (HP:0002509)1.87138442
161Pancreatitis (HP:0001733)1.86550590
162Osteoarthritis (HP:0002758)1.85733635
163Neonatal short-limb short stature (HP:0008921)1.85151929
164Flattened epiphyses (HP:0003071)1.85096448
165Spondylolisthesis (HP:0003302)1.84551729
166Unilateral renal agenesis (HP:0000122)1.83962198
167Blue sclerae (HP:0000592)1.83710856
168Hyperaldosteronism (HP:0000859)1.82528998
169Aneurysm (HP:0002617)1.82366888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.66450039
2FRK4.21572785
3PASK4.12364622
4MYLK3.71986928
5TAOK33.68590792
6ERN13.46768912
7MAPK153.08161334
8TRPM72.75613035
9BCKDK2.55933389
10MAP3K22.53435286
11SIK12.46242873
12FLT32.38284698
13MAP3K32.32667183
14MAP3K122.11710199
15PRKD32.11489589
16HIPK22.03982540
17LATS12.01613695
18ACVR1B2.00870600
19LIMK12.00806202
20WNK41.86032423
21MST1R1.82573152
22MET1.68469814
23PTK61.64857030
24TRIB31.58060799
25FGFR41.52282764
26FGFR21.46396606
27STK38L1.45352430
28TGFBR21.42478433
29NUAK11.36657430
30GRK11.32207829
31WNK31.31796483
32IRAK31.30424041
33AKT31.29196068
34PTK21.28697629
35MAPKAPK31.27750899
36DAPK21.24705108
37EPHA31.19508605
38ADRBK21.17490068
39TIE11.17190891
40PDGFRA1.13840652
41MAP3K11.12618916
42MAP2K61.11217182
43PRKG21.08956014
44PAK41.08096061
45MAP2K21.05125073
46NTRK11.04388515
47EIF2AK31.02885751
48PHKG21.02621245
49PHKG11.02621245
50TTN1.01864716
51STK381.01588958
52EPHB20.97862438
53STK240.96127588
54DDR20.96125552
55DYRK1B0.95706238
56PAK20.94358294
57PTK2B0.89452493
58ABL20.89277713
59ERBB40.85548761
60ROCK10.85156390
61RIPK10.84032164
62MST40.83339114
63PIK3CG0.83322322
64SCYL20.82516296
65JAK10.80573934
66FER0.79497568
67LMTK20.79240938
68JAK20.78970347
69CAMKK20.77164440
70PAK30.76315363
71TAOK10.73855408
72PRKAA10.73242793
73ADRBK10.72913679
74CDC42BPA0.72648839
75PRKCH0.71065789
76IRAK10.69413718
77PIK3CA0.69229748
78MAP3K100.68332220
79ROCK20.66047470
80GSK3A0.65880925
81FGFR30.65073389
82PKN20.64105522
83EPHB10.62775583
84DAPK30.61773760
85NLK0.61697440
86SGK30.61380663
87EPHA20.60126178
88SGK20.58771576
89PRKAA20.57926807
90MAP3K90.56815102
91ERBB30.55977272
92LATS20.55216785
93OXSR10.53656886
94PRKACG0.53568161
95MAP3K140.53267937
96JAK30.52032121
97CAMK1G0.51524817
98PRKD20.51170925
99ZAP700.50143109
100YES10.50104342
101ITK0.48890124
102PRKCE0.48657183
103MAPK110.48374294
104ILK0.46746362
105GRK70.46674916
106PRKCI0.46557238
107SGK4940.45678719
108SGK2230.45678719
109TYK20.45495113
110CHUK0.45261137
111IGF1R0.44733155
112RET0.44517843
113TBK10.41753763
114MELK0.40194687
115PDPK10.39442151
116MAP2K10.39307866
117CAMK2G0.38871244
118BRSK20.37843524
119STK30.36668882
120NEK60.33946471
121NTRK30.33701505
122STK390.33316003
123PINK10.33049720
124CSK0.31291477
125BMPR20.30790663
126AKT20.30677399
127NME10.30278239
128RPS6KB10.29789294
129TEC0.29558893
130CSNK1A10.29281153
131CAMK1D0.29079679
132MTOR0.29066945
133NEK90.27723136
134PRKD10.27038868
135PRKCA0.25861008
136TESK10.25529592
137ERBB20.24836835
138CAMK2D0.22314609
139PRKCZ0.21490571
140PRKACA0.21158545
141PDGFRB0.20495603
142RPS6KA20.18249802

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.88051085
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.13302714
3Nitrogen metabolism_Homo sapiens_hsa009102.62343505
4* Sulfur metabolism_Homo sapiens_hsa009202.61587209
5Tryptophan metabolism_Homo sapiens_hsa003802.58428441
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.56552288
7Protein export_Homo sapiens_hsa030602.52465311
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.50673527
9Butanoate metabolism_Homo sapiens_hsa006502.23866752
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21470170
11Starch and sucrose metabolism_Homo sapiens_hsa005002.06680286
12Vitamin B6 metabolism_Homo sapiens_hsa007502.04717840
13Fatty acid degradation_Homo sapiens_hsa000712.01089470
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87814604
15Folate biosynthesis_Homo sapiens_hsa007901.86705641
16Histidine metabolism_Homo sapiens_hsa003401.75377681
17Arginine biosynthesis_Homo sapiens_hsa002201.75003629
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73701601
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70006898
20Fat digestion and absorption_Homo sapiens_hsa049751.67441830
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60236579
22Peroxisome_Homo sapiens_hsa041461.59384513
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55018772
24Bile secretion_Homo sapiens_hsa049761.49980916
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44263115
26ABC transporters_Homo sapiens_hsa020101.41499902
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41230610
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40748313
29* Selenocompound metabolism_Homo sapiens_hsa004501.40363064
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.39854925
31Chemical carcinogenesis_Homo sapiens_hsa052041.39807813
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39232530
33Phenylalanine metabolism_Homo sapiens_hsa003601.34191506
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.34127777
35Galactose metabolism_Homo sapiens_hsa000521.31262785
36Fatty acid metabolism_Homo sapiens_hsa012121.31169010
37Complement and coagulation cascades_Homo sapiens_hsa046101.30944303
38Caffeine metabolism_Homo sapiens_hsa002321.29736457
39Propanoate metabolism_Homo sapiens_hsa006401.27874320
40PPAR signaling pathway_Homo sapiens_hsa033201.26345774
41ECM-receptor interaction_Homo sapiens_hsa045121.24396842
42Ovarian steroidogenesis_Homo sapiens_hsa049131.21340647
43Vitamin digestion and absorption_Homo sapiens_hsa049771.16801323
44Insulin secretion_Homo sapiens_hsa049111.15982298
45beta-Alanine metabolism_Homo sapiens_hsa004101.14211294
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13965612
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10205150
48Tyrosine metabolism_Homo sapiens_hsa003501.06833715
49Type II diabetes mellitus_Homo sapiens_hsa049301.06728127
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06391837
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05897436
52Retinol metabolism_Homo sapiens_hsa008301.04645703
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02784165
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97447773
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.93452547
56Arginine and proline metabolism_Homo sapiens_hsa003300.90199831
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89857319
58Focal adhesion_Homo sapiens_hsa045100.88890310
59Lysine degradation_Homo sapiens_hsa003100.87930481
60Protein digestion and absorption_Homo sapiens_hsa049740.85541853
61Pyruvate metabolism_Homo sapiens_hsa006200.84494769
62Amoebiasis_Homo sapiens_hsa051460.84150116
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83770522
64Fatty acid elongation_Homo sapiens_hsa000620.80716328
65Insulin resistance_Homo sapiens_hsa049310.80403946
66Pertussis_Homo sapiens_hsa051330.79377100
67Renin secretion_Homo sapiens_hsa049240.79124737
68Collecting duct acid secretion_Homo sapiens_hsa049660.78866471
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78553209
70Vibrio cholerae infection_Homo sapiens_hsa051100.78499706
71Mineral absorption_Homo sapiens_hsa049780.75776207
72N-Glycan biosynthesis_Homo sapiens_hsa005100.75127891
73Arachidonic acid metabolism_Homo sapiens_hsa005900.74772789
74Renin-angiotensin system_Homo sapiens_hsa046140.73918180
75Steroid biosynthesis_Homo sapiens_hsa001000.73157521
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.71182776
77Fructose and mannose metabolism_Homo sapiens_hsa000510.70200989
78Thyroid hormone synthesis_Homo sapiens_hsa049180.66867953
79Other glycan degradation_Homo sapiens_hsa005110.66342777
80Dorso-ventral axis formation_Homo sapiens_hsa043200.64932395
81Lysosome_Homo sapiens_hsa041420.63398827
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63080657
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.62360710
84Tight junction_Homo sapiens_hsa045300.62323918
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61685846
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60782641
87Carbon metabolism_Homo sapiens_hsa012000.58143367
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57952597
89TGF-beta signaling pathway_Homo sapiens_hsa043500.56819194
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54757699
91Proteoglycans in cancer_Homo sapiens_hsa052050.54407577
92Glycerolipid metabolism_Homo sapiens_hsa005610.54371598
93Glutathione metabolism_Homo sapiens_hsa004800.54239262
94Staphylococcus aureus infection_Homo sapiens_hsa051500.53708145
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48651987
96Type I diabetes mellitus_Homo sapiens_hsa049400.47525106
97Ether lipid metabolism_Homo sapiens_hsa005650.46684609
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46409712
99Glucagon signaling pathway_Homo sapiens_hsa049220.46312553
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.45926349
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43998028
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41391511
103Sulfur relay system_Homo sapiens_hsa041220.41292833
104Sphingolipid metabolism_Homo sapiens_hsa006000.40871164
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39896075
106* Metabolic pathways_Homo sapiens_hsa011000.38700719
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38305516
108Circadian rhythm_Homo sapiens_hsa047100.37876439
109Cocaine addiction_Homo sapiens_hsa050300.36019569
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35883989
111Linoleic acid metabolism_Homo sapiens_hsa005910.35681756
112Biosynthesis of amino acids_Homo sapiens_hsa012300.35312264
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32885948
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32292438
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32091337
116Pancreatic secretion_Homo sapiens_hsa049720.29558735
117Prion diseases_Homo sapiens_hsa050200.24446298
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22718412
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.22422180
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.21802266
121Regulation of autophagy_Homo sapiens_hsa041400.20054251
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20050443
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16117950
124AMPK signaling pathway_Homo sapiens_hsa041520.15663367
125Prolactin signaling pathway_Homo sapiens_hsa049170.15344035
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.14303870

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