PAPOLA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.42978430
2nuclear pore organization (GO:0006999)5.34644808
3mitotic sister chromatid cohesion (GO:0007064)4.95128549
4synapsis (GO:0007129)4.73478658
5DNA unwinding involved in DNA replication (GO:0006268)4.26220942
6protein localization to kinetochore (GO:0034501)4.25652942
7mitotic nuclear envelope disassembly (GO:0007077)4.19601237
8sister chromatid cohesion (GO:0007062)4.06707865
9regulation of spindle organization (GO:0090224)3.99958656
10pore complex assembly (GO:0046931)3.99392769
11regulation of RNA export from nucleus (GO:0046831)3.98323453
12nuclear envelope disassembly (GO:0051081)3.92938053
13membrane disassembly (GO:0030397)3.92938053
14mitotic chromosome condensation (GO:0007076)3.90909394
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.90273424
16mitotic metaphase plate congression (GO:0007080)3.84787687
17protein localization to chromosome, centromeric region (GO:0071459)3.83236664
18pre-miRNA processing (GO:0031054)3.79390089
19sister chromatid segregation (GO:0000819)3.70551102
20histone H2A acetylation (GO:0043968)3.66022780
21regulation of sister chromatid cohesion (GO:0007063)3.64823000
22positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.61163045
23positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.61163045
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.61163045
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60965916
26positive regulation of chromosome segregation (GO:0051984)3.56657657
27metaphase plate congression (GO:0051310)3.51721634
28keratinocyte development (GO:0003334)3.51379867
29negative regulation of histone methylation (GO:0031061)3.48005818
30V(D)J recombination (GO:0033151)3.46987644
31non-recombinational repair (GO:0000726)3.46124579
32double-strand break repair via nonhomologous end joining (GO:0006303)3.46124579
33folic acid-containing compound biosynthetic process (GO:0009396)3.43940479
34kinetochore organization (GO:0051383)3.41203736
35regulation of centrosome duplication (GO:0010824)3.40808906
36regulation of mitotic spindle organization (GO:0060236)3.40287046
37DNA duplex unwinding (GO:0032508)3.35453742
38Golgi transport vesicle coating (GO:0048200)3.34299267
39COPI coating of Golgi vesicle (GO:0048205)3.34299267
40DNA geometric change (GO:0032392)3.33827613
41mitotic sister chromatid segregation (GO:0000070)3.32062264
42DNA ligation (GO:0006266)3.30305523
43COPII vesicle coating (GO:0048208)3.28454289
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.28426399
45dosage compensation (GO:0007549)3.26646961
46heterochromatin organization (GO:0070828)3.25976008
47DNA replication-dependent nucleosome organization (GO:0034723)3.24964843
48DNA replication-dependent nucleosome assembly (GO:0006335)3.24964843
49regulation of histone H3-K9 methylation (GO:0051570)3.24368476
50attachment of spindle microtubules to kinetochore (GO:0008608)3.22481977
51IMP biosynthetic process (GO:0006188)3.21409602
52DNA synthesis involved in DNA repair (GO:0000731)3.20952822
53meiotic chromosome segregation (GO:0045132)3.20821242
54glucocorticoid receptor signaling pathway (GO:0042921)3.19846505
55nucleobase biosynthetic process (GO:0046112)3.17066297
56DNA topological change (GO:0006265)3.15890535
57nuclear envelope organization (GO:0006998)3.15760652
58formation of translation preinitiation complex (GO:0001731)3.13749250
59positive regulation of histone H3-K4 methylation (GO:0051571)3.12344457
60regulation of chromosome segregation (GO:0051983)3.09805944
61neural tube formation (GO:0001841)3.08964067
62negative regulation of RNA splicing (GO:0033119)3.07836478
63ribosome assembly (GO:0042255)3.07541522
64monoubiquitinated protein deubiquitination (GO:0035520)3.06261534
65purine nucleobase biosynthetic process (GO:0009113)3.06181125
66regulation of DNA endoreduplication (GO:0032875)3.04428213
67protein localization to chromosome (GO:0034502)3.02219533
68DNA replication-independent nucleosome organization (GO:0034724)3.02146386
69DNA replication-independent nucleosome assembly (GO:0006336)3.02146386
70chromosome organization involved in meiosis (GO:0070192)3.01862371
71DNA replication initiation (GO:0006270)3.01502217
72histone H2A monoubiquitination (GO:0035518)3.01392736
73piRNA metabolic process (GO:0034587)3.01183173
74regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01142305
75establishment of chromosome localization (GO:0051303)3.00812304
76DNA replication checkpoint (GO:0000076)3.00007385
77regulation of nucleobase-containing compound transport (GO:0032239)2.99632412
78regulation of centrosome cycle (GO:0046605)2.99277354
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98618166
80chromatin assembly (GO:0031497)2.96125838
81mRNA stabilization (GO:0048255)2.95195215
82RNA stabilization (GO:0043489)2.95195215
83chromatin assembly or disassembly (GO:0006333)2.94234071
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93566211
85spindle checkpoint (GO:0031577)2.93540889
86negative regulation of mRNA metabolic process (GO:1903312)2.93467131
87NLS-bearing protein import into nucleus (GO:0006607)2.93090906
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.92765233
89regulation of chromatin silencing (GO:0031935)2.92665537
90spindle assembly checkpoint (GO:0071173)2.91122446
91positive regulation of SMAD protein import into nucleus (GO:0060391)2.90157739
92histone-serine phosphorylation (GO:0035404)2.88688821
93Golgi to endosome transport (GO:0006895)2.87233524
94ATP-dependent chromatin remodeling (GO:0043044)2.86510287
95genitalia morphogenesis (GO:0035112)2.85938511
96chromatin remodeling at centromere (GO:0031055)2.85693203
97mitotic spindle assembly checkpoint (GO:0007094)2.85264363
98mRNA transport (GO:0051028)2.84559153
99negative regulation of mRNA processing (GO:0050686)2.83683799
100negative regulation of chromosome segregation (GO:0051985)2.82889723
101translesion synthesis (GO:0019985)2.82885472
102DNA strand elongation involved in DNA replication (GO:0006271)2.82322891
103mitotic spindle checkpoint (GO:0071174)2.81725653
104resolution of meiotic recombination intermediates (GO:0000712)2.81468793
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.80818295
106regulation of translational fidelity (GO:0006450)2.80547053
107regulation of sister chromatid segregation (GO:0033045)2.80246176
108regulation of mitotic sister chromatid separation (GO:0010965)2.80246176
109regulation of mitotic sister chromatid segregation (GO:0033047)2.80246176
110regulation of meiosis I (GO:0060631)2.79860283
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.79681000
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.79681000
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.79681000
114negative regulation of sister chromatid segregation (GO:0033046)2.79681000
115nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79426482
116CENP-A containing nucleosome assembly (GO:0034080)2.78712254
117DNA conformation change (GO:0071103)2.78622849
118somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.78255946
119somatic cell DNA recombination (GO:0016444)2.78255946
120positive regulation of cell cycle checkpoint (GO:1901978)2.77399853
121regulation of acyl-CoA biosynthetic process (GO:0050812)2.76608036
122kinetochore assembly (GO:0051382)2.75251126
123male meiosis (GO:0007140)2.74184437
124DNA double-strand break processing (GO:0000729)2.74059660
125mRNA modification (GO:0016556)2.73899643
126regulation of translational termination (GO:0006449)2.72328234
127regulation of centriole replication (GO:0046599)2.71781716
128gene silencing by RNA (GO:0031047)2.70837588
129DNA strand elongation (GO:0022616)2.70587568
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.70507858
131intestinal epithelial cell development (GO:0060576)2.69339784
132paraxial mesoderm development (GO:0048339)2.68134203
133male meiosis I (GO:0007141)2.67615551
134histone mRNA catabolic process (GO:0071044)2.67390878
135acrosome assembly (GO:0001675)2.66877880
136positive regulation of glycoprotein biosynthetic process (GO:0010560)2.65114158
137phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.64731584
138negative regulation of execution phase of apoptosis (GO:1900118)2.63045898
139RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62789173
140histone exchange (GO:0043486)2.59871830
141regulation of coenzyme metabolic process (GO:0051196)2.59686908
142regulation of cofactor metabolic process (GO:0051193)2.59686908
143meiotic nuclear division (GO:0007126)2.58434517
144protein K11-linked deubiquitination (GO:0035871)2.58350883
145somatic diversification of immune receptors (GO:0002200)2.57637000
146hepatocyte apoptotic process (GO:0097284)2.57494773
147peptidyl-lysine trimethylation (GO:0018023)2.56227328
148lactate metabolic process (GO:0006089)2.55700892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.21783478
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.32847892
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.98601261
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85098718
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.32063873
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23035580
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.94847301
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.92706816
9AR_21909140_ChIP-Seq_LNCAP_Human2.72142992
10MYC_22102868_ChIP-Seq_BL_Human2.64601608
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60508074
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45068561
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.43107882
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42341751
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26766343
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23893127
17FUS_26573619_Chip-Seq_HEK293_Human2.22137134
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19130515
19IGF1R_20145208_ChIP-Seq_DFB_Human2.14786421
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10929634
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.09829766
22ZNF274_21170338_ChIP-Seq_K562_Hela2.07157605
23EWS_26573619_Chip-Seq_HEK293_Human2.06918987
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.04018848
25TAF15_26573619_Chip-Seq_HEK293_Human2.03656400
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95147520
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93667005
28CIITA_25753668_ChIP-Seq_RAJI_Human1.88460328
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87543807
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86123963
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81875593
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.75377421
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73895843
34XRN2_22483619_ChIP-Seq_HELA_Human1.73466546
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72416281
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71992519
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69872307
38KDM5A_27292631_Chip-Seq_BREAST_Human1.68255307
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65636975
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65482522
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.63927912
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62593388
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62100352
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59556841
45VDR_23849224_ChIP-Seq_CD4+_Human1.57534020
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55839042
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52127710
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50911814
49* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48898015
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48478452
51ELK1_19687146_ChIP-ChIP_HELA_Human1.45282239
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.44311335
53FOXP3_21729870_ChIP-Seq_TREG_Human1.42822822
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42203155
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.41930316
56* ETS1_20019798_ChIP-Seq_JURKAT_Human1.41839120
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40944921
58* P300_19829295_ChIP-Seq_ESCs_Human1.39422521
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37800742
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37260948
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37088377
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36816174
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35913012
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35620508
65* GABP_19822575_ChIP-Seq_HepG2_Human1.35101817
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.33320486
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33166712
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32868708
69ER_23166858_ChIP-Seq_MCF-7_Human1.32162875
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30953305
71* CHD1_26751641_Chip-Seq_LNCaP_Human1.30745907
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30109650
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30093006
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28200878
75TFEB_21752829_ChIP-Seq_HELA_Human1.27828531
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27471491
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.26966031
78TTF2_22483619_ChIP-Seq_HELA_Human1.26833229
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25711401
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25525732
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.24787898
82FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.24743165
83DCP1A_22483619_ChIP-Seq_HELA_Human1.22623873
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.20072311
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19074005
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18806413
87STAT3_23295773_ChIP-Seq_U87_Human1.18253386
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17147625
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.16742449
90* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15485740
91ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15469377
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15361003
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15321359
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14777325
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14718253
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14278036
97* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13467136
98SMAD4_21799915_ChIP-Seq_A2780_Human1.11797863
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11257195
100CLOCK_20551151_ChIP-Seq_293T_Human1.10443015
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10386998
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10057773
103* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09932735
104CBP_20019798_ChIP-Seq_JUKART_Human1.09707047
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09707047
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09398554
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.08235340
108VDR_21846776_ChIP-Seq_THP-1_Human1.07809778
109TCF4_23295773_ChIP-Seq_U87_Human1.07214851
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06509710
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06318527
112FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05358456
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05085562
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04911019
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04746685
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03979401
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03473980
118CDX2_22108803_ChIP-Seq_LS180_Human1.03333427
119GATA1_22025678_ChIP-Seq_K562_Human1.03329036
120TCF7_22412390_ChIP-Seq_EML_Mouse1.03107259
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02634602
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.02509320
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02311628
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.01540630
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01331502
126VDR_22108803_ChIP-Seq_LS180_Human1.01245992
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00234930
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00097174
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98918809
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98818617
131JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98172784
132HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97394526
133MYB_26560356_Chip-Seq_TH1_Human0.95505427
134ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95467823
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95434380
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95235312
137GBX2_23144817_ChIP-Seq_PC3_Human0.94424084
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.94314940
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93801882
140P300_18555785_Chip-Seq_ESCs_Mouse0.93235879
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93166689
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92765392
143FOXA1_25552417_ChIP-Seq_VCAP_Human0.92678366
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92605169
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92296578
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91952997
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91849610
148TCF4_22108803_ChIP-Seq_LS180_Human0.91743800
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91609711
150RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90707767
151SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90429825
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90267869
153ZNF263_19887448_ChIP-Seq_K562_Human0.90267345
154OCT4_18555785_Chip-Seq_ESCs_Mouse0.89754750
155UTX_26944678_Chip-Seq_JUKART_Human0.89694663
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87712814
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87712814
158KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87712814
159MYB_26560356_Chip-Seq_TH2_Human0.86884713
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85200607
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85139902
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84487374
163GATA6_25053715_ChIP-Seq_YYC3_Human0.83446867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.53483494
2MP0004957_abnormal_blastocyst_morpholog3.09656521
3MP0003111_abnormal_nucleus_morphology3.08516956
4MP0010094_abnormal_chromosome_stability3.08395572
5MP0008057_abnormal_DNA_replication2.88306613
6MP0010352_gastrointestinal_tract_polyps2.77370959
7MP0003077_abnormal_cell_cycle2.74516070
8MP0005076_abnormal_cell_differentiation2.40248325
9MP0003123_paternal_imprinting2.37414276
10MP0001730_embryonic_growth_arrest2.16857784
11MP0003705_abnormal_hypodermis_morpholog2.15096050
12MP0010307_abnormal_tumor_latency2.14376984
13MP0006054_spinal_hemorrhage2.13723136
14MP0000427_abnormal_hair_cycle2.12001934
15MP0010234_abnormal_vibrissa_follicle1.98580764
16MP0000537_abnormal_urethra_morphology1.89858096
17MP0001672_abnormal_embryogenesis/_devel1.89469995
18MP0005380_embryogenesis_phenotype1.89469995
19MP0000350_abnormal_cell_proliferation1.88178777
20MP0002877_abnormal_melanocyte_morpholog1.87797128
21MP0008007_abnormal_cellular_replicative1.84896767
22MP0003984_embryonic_growth_retardation1.84190411
23MP0002088_abnormal_embryonic_growth/wei1.81896075
24MP0004264_abnormal_extraembryonic_tissu1.81827753
25MP0004197_abnormal_fetal_growth/weight/1.79709141
26MP0008058_abnormal_DNA_repair1.79435635
27MP0009780_abnormal_chondrocyte_physiolo1.78941895
28MP0009697_abnormal_copulation1.77859781
29MP0002396_abnormal_hematopoietic_system1.76271670
30MP0003567_abnormal_fetal_cardiomyocyte1.73590783
31MP0008877_abnormal_DNA_methylation1.73241202
32MP0002084_abnormal_developmental_patter1.72833451
33MP0001697_abnormal_embryo_size1.72783340
34MP0003121_genomic_imprinting1.70905333
35MP0002086_abnormal_extraembryonic_tissu1.68596467
36MP0003943_abnormal_hepatobiliary_system1.66769575
37MP0003890_abnormal_embryonic-extraembry1.65942132
38MP0000647_abnormal_sebaceous_gland1.60480973
39MP0009672_abnormal_birth_weight1.57991936
40MP0004808_abnormal_hematopoietic_stem1.57653318
41MP0002085_abnormal_embryonic_tissue1.56281429
42MP0003300_gastrointestinal_ulcer1.53634347
43MP0009053_abnormal_anal_canal1.52077000
44MP0008932_abnormal_embryonic_tissue1.50653568
45MP0001293_anophthalmia1.49066124
46MP0002080_prenatal_lethality1.45897507
47MP0009703_decreased_birth_body1.37664624
48MP0000428_abnormal_craniofacial_morphol1.37572500
49MP0010030_abnormal_orbit_morphology1.33330563
50MP0001929_abnormal_gametogenesis1.33115572
51MP0003941_abnormal_skin_development1.30521535
52MP0002254_reproductive_system_inflammat1.27372044
53MP0008995_early_reproductive_senescence1.26354933
54MP0002210_abnormal_sex_determination1.24980262
55MP0002909_abnormal_adrenal_gland1.24404590
56MP0003221_abnormal_cardiomyocyte_apopto1.20207219
57MP0005379_endocrine/exocrine_gland_phen1.19097803
58MP0000569_abnormal_digit_pigmentation1.18556536
59MP0000733_abnormal_muscle_development1.17841106
60MP0002160_abnormal_reproductive_system1.17257267
61MP0003119_abnormal_digestive_system1.17125740
62MP0003183_abnormal_peptide_metabolism1.16292539
63MP0003718_maternal_effect1.16100537
64MP0002837_dystrophic_cardiac_calcinosis1.14718843
65MP0000653_abnormal_sex_gland1.13701983
66MP0000490_abnormal_crypts_of1.09490451
67MP0002092_abnormal_eye_morphology1.09104129
68MP0003935_abnormal_craniofacial_develop1.08550589
69MP0009278_abnormal_bone_marrow1.08016070
70MP0003566_abnormal_cell_adhesion1.07637714
71MP0002009_preneoplasia1.06887076
72MP0003195_calcinosis1.06029345
73MP0000313_abnormal_cell_death1.03784601
74MP0003937_abnormal_limbs/digits/tail_de1.03264495
75MP0002166_altered_tumor_susceptibility1.03013883
76MP0000013_abnormal_adipose_tissue1.02368446
77MP0003115_abnormal_respiratory_system1.02147640
78MP0005220_abnormal_exocrine_pancreas1.00100301
79MP0005187_abnormal_penis_morphology0.97069727
80MP0001849_ear_inflammation0.96763520
81MP0002019_abnormal_tumor_incidence0.96541379
82MP0000703_abnormal_thymus_morphology0.96044856
83MP0006072_abnormal_retinal_apoptosis0.94768382
84MP0001915_intracranial_hemorrhage0.94556570
85MP0010678_abnormal_skin_adnexa0.93969548
86MP0003283_abnormal_digestive_organ0.93490224
87MP0002163_abnormal_gland_morphology0.91714878
88MP0002876_abnormal_thyroid_physiology0.90416737
89MP0005253_abnormal_eye_physiology0.89674695
90MP0002925_abnormal_cardiovascular_devel0.89572006
91MP0000432_abnormal_head_morphology0.89358497
92MP0003698_abnormal_male_reproductive0.88763332
93MP0000516_abnormal_urinary_system0.88346447
94MP0005367_renal/urinary_system_phenotyp0.88346447
95MP0002090_abnormal_vision0.87338161
96MP0005174_abnormal_tail_pigmentation0.87184580
97MP0008961_abnormal_basal_metabolism0.85687310
98MP0004782_abnormal_surfactant_physiolog0.84894930
99MP0005389_reproductive_system_phenotype0.83653440
100MP0002697_abnormal_eye_size0.83280749
101MP0000003_abnormal_adipose_tissue0.83089841
102MP0005397_hematopoietic_system_phenotyp0.81318922
103MP0001545_abnormal_hematopoietic_system0.81318922
104MP0005023_abnormal_wound_healing0.81144332
105MP0001188_hyperpigmentation0.81131699
106MP0000631_abnormal_neuroendocrine_gland0.80326702
107MP0000383_abnormal_hair_follicle0.79427142
108MP0005645_abnormal_hypothalamus_physiol0.79375718
109MP0000377_abnormal_hair_follicle0.78787852
110MP0001286_abnormal_eye_development0.78510173
111MP0003868_abnormal_feces_composition0.78494519
112MP0005075_abnormal_melanosome_morpholog0.78157906
113MP0002111_abnormal_tail_morphology0.77554615
114MP0003656_abnormal_erythrocyte_physiolo0.74680540
115MP0002796_impaired_skin_barrier0.73663252
116MP0006035_abnormal_mitochondrial_morpho0.73659688
117MP0000358_abnormal_cell_content/0.73417175
118MP0001666_abnormal_nutrient_absorption0.73183631
119MP0005248_abnormal_Harderian_gland0.72244590
120MP0004215_abnormal_myocardial_fiber0.72148060
121MP0005451_abnormal_body_composition0.71390374
122MP0003786_premature_aging0.70958860
123MP0001119_abnormal_female_reproductive0.70873291
124MP0009333_abnormal_splenocyte_physiolog0.70815013
125MP0000266_abnormal_heart_morphology0.70421234
126MP0002006_tumorigenesis0.70011605
127MP0001661_extended_life_span0.69821605
128MP0001944_abnormal_pancreas_morphology0.69790970
129MP0000477_abnormal_intestine_morphology0.69708399
130MP0003936_abnormal_reproductive_system0.69019762
131MP0005621_abnormal_cell_physiology0.68108676
132MP0000371_diluted_coat_color0.68050962
133MP0003755_abnormal_palate_morphology0.67954385
134MP0003787_abnormal_imprinting0.67825241
135MP0004233_abnormal_muscle_weight0.66834478
136MP0002098_abnormal_vibrissa_morphology0.66240299
137MP0003122_maternal_imprinting0.65637646
138MP0005384_cellular_phenotype0.65432387
139MP0002938_white_spotting0.65207080
140MP0001145_abnormal_male_reproductive0.64622894
141MP0002932_abnormal_joint_morphology0.64572108
142MP0000627_abnormal_mammary_gland0.64268112
143MP0003763_abnormal_thymus_physiology0.64026778
144MP0009384_cardiac_valve_regurgitation0.63179485

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.72889311
2Short 4th metacarpal (HP:0010044)3.30499582
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.30499582
4Thyroid carcinoma (HP:0002890)3.23599941
5Colon cancer (HP:0003003)3.10390350
6Thyroiditis (HP:0100646)3.09589674
7Intestinal atresia (HP:0011100)3.05805606
8Abnormality of the fingertips (HP:0001211)2.85922604
9Proximal placement of thumb (HP:0009623)2.83755281
10Deviation of the thumb (HP:0009603)2.83738243
11Increased nuchal translucency (HP:0010880)2.77681899
12Ependymoma (HP:0002888)2.72748703
13B lymphocytopenia (HP:0010976)2.70854354
14Long eyelashes (HP:0000527)2.69722667
15Hypoproteinemia (HP:0003075)2.64802743
16Nephroblastoma (Wilms tumor) (HP:0002667)2.63805946
17Selective tooth agenesis (HP:0001592)2.62850679
18Biliary tract neoplasm (HP:0100574)2.61337389
19Medulloblastoma (HP:0002885)2.60549065
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.58793023
21Neoplasm of the adrenal cortex (HP:0100641)2.54546539
22Embryonal renal neoplasm (HP:0011794)2.51630032
23Curly hair (HP:0002212)2.50997614
24Prominent nose (HP:0000448)2.45598905
25Hypoplasia of the thymus (HP:0000778)2.44736485
26Abnormality of the 4th metacarpal (HP:0010012)2.44351662
27Abnormality of endocrine pancreas physiology (HP:0012093)2.42054430
28Abnormality of the pancreatic islet cells (HP:0006476)2.42054430
29Severe combined immunodeficiency (HP:0004430)2.41437687
30Abnormality of B cell number (HP:0010975)2.39643085
31Hypoglycemic seizures (HP:0002173)2.38399862
32Abnormality of the anterior horn cell (HP:0006802)2.37806549
33Degeneration of anterior horn cells (HP:0002398)2.37806549
34Gastrointestinal carcinoma (HP:0002672)2.36241967
35Malignant gastrointestinal tract tumors (HP:0006749)2.36241967
36Rectal prolapse (HP:0002035)2.34711385
37Breast carcinoma (HP:0003002)2.33666696
38Fair hair (HP:0002286)2.33393252
39Short middle phalanx of the 5th finger (HP:0004220)2.30010332
40Birth length less than 3rd percentile (HP:0003561)2.29637072
41Oligodactyly (hands) (HP:0001180)2.28987624
42Combined immunodeficiency (HP:0005387)2.25088381
43Hyperinsulinemic hypoglycemia (HP:0000825)2.24934364
44Atresia of the external auditory canal (HP:0000413)2.20262671
45Rhabdomyosarcoma (HP:0002859)2.20052466
46Neoplasm of the oral cavity (HP:0100649)2.17025996
47Truncal obesity (HP:0001956)2.15260686
48Pelvic girdle muscle weakness (HP:0003749)2.13673098
49Ectopic kidney (HP:0000086)2.11938610
50Aqueductal stenosis (HP:0002410)2.10760321
51Glioma (HP:0009733)2.08032086
52Basal cell carcinoma (HP:0002671)2.07550341
53Hypoplastic labia majora (HP:0000059)2.07384628
54Septate vagina (HP:0001153)2.04661478
55Hepatoblastoma (HP:0002884)2.03782245
56Broad thumb (HP:0011304)2.02964340
57T lymphocytopenia (HP:0005403)2.02756148
58Abnormality of the astrocytes (HP:0100707)2.02742204
59Astrocytoma (HP:0009592)2.02742204
60Bladder neoplasm (HP:0009725)2.01440893
61Bladder carcinoma (HP:0002862)2.01440893
62Gonadotropin excess (HP:0000837)2.00919515
63Widely spaced teeth (HP:0000687)2.00150424
64Cutaneous melanoma (HP:0012056)1.98893065
65Agnosia (HP:0010524)1.98227394
66Asymmetry of the thorax (HP:0001555)1.97624649
67Short 5th finger (HP:0009237)1.97520943
68Low anterior hairline (HP:0000294)1.97225751
69Uterine neoplasm (HP:0010784)1.96802548
70Subacute progressive viral hepatitis (HP:0006572)1.95891671
71Deep philtrum (HP:0002002)1.95837036
72Supernumerary ribs (HP:0005815)1.95155543
73Long clavicles (HP:0000890)1.94398617
74Impulsivity (HP:0100710)1.94269379
75Syringomyelia (HP:0003396)1.93922721
76Spinal cord lesions (HP:0100561)1.93922721
77Abnormality of vitamin B metabolism (HP:0004340)1.93721693
78Macroorchidism (HP:0000053)1.93082827
79Abnormal biliary tract morphology (HP:0012440)1.93030695
80Blepharitis (HP:0000498)1.92335155
81Patellar aplasia (HP:0006443)1.91884858
82Facial hemangioma (HP:0000329)1.91528914
83Broad palm (HP:0001169)1.89994608
84Hypoglycemic coma (HP:0001325)1.89823588
85Renal duplication (HP:0000075)1.89663910
86Neoplasm of striated muscle (HP:0009728)1.89606464
87Narrow palate (HP:0000189)1.89039559
88Aplasia/Hypoplasia of the patella (HP:0006498)1.88413937
89Neoplasm of the pancreas (HP:0002894)1.87327871
90Cutis marmorata (HP:0000965)1.87189920
91Abnormality of the labia majora (HP:0012881)1.87063504
92Abnormality of chromosome stability (HP:0003220)1.86610664
93Abnormal lung lobation (HP:0002101)1.86551688
94Pancreatic islet-cell hyperplasia (HP:0004510)1.86457882
95Missing ribs (HP:0000921)1.86317466
96Shallow orbits (HP:0000586)1.86156281
97Trigonocephaly (HP:0000243)1.85991915
98Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.85306092
99Ovarian neoplasm (HP:0100615)1.85072444
100Abnormality of the renal cortex (HP:0011035)1.84040072
101Proximal tubulopathy (HP:0000114)1.83714713
102Skin tags (HP:0010609)1.82086203
103Sloping forehead (HP:0000340)1.81468573
104Neoplasm of the adrenal gland (HP:0100631)1.81082541
105Urethral obstruction (HP:0000796)1.80909651
106Overlapping toe (HP:0001845)1.80505687
107Tubulointerstitial nephritis (HP:0001970)1.80046625
108Neoplasm of the thyroid gland (HP:0100031)1.79686297
109Abnormal pancreas size (HP:0012094)1.78546288
110Broad phalanges of the hand (HP:0009768)1.78442231
111Cystic hygroma (HP:0000476)1.78287874
112Anal stenosis (HP:0002025)1.78174012
113Enlarged penis (HP:0000040)1.77950962
114Sparse lateral eyebrow (HP:0005338)1.77080821
115High pitched voice (HP:0001620)1.76905646
116Absent eyebrow (HP:0002223)1.75173296
117Neoplasm of the small intestine (HP:0100833)1.74601666
118Hyperacusis (HP:0010780)1.74450430
119Breast hypoplasia (HP:0003187)1.74272576
120Hematochezia (HP:0002573)1.74074853
121Sandal gap (HP:0001852)1.73086521
122Intestinal polyp (HP:0005266)1.71691121
123Abnormal hair whorl (HP:0010721)1.71590660
124Skull defect (HP:0001362)1.71335285
125Intestinal polyposis (HP:0200008)1.71090833
126Clitoromegaly (HP:0000057)1.71058237
127Horizontal nystagmus (HP:0000666)1.70732072
128Abnormal number of incisors (HP:0011064)1.69630939
129Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.68613888
130Embryonal neoplasm (HP:0002898)1.68456905
131Ketoacidosis (HP:0001993)1.67725086
132Hyperglycemia (HP:0003074)1.67271737
133Abnormality of T cell number (HP:0011839)1.67071157
134Acute myeloid leukemia (HP:0004808)1.66962729
135Transitional cell carcinoma of the bladder (HP:0006740)1.65831111
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.65769848
137Methylmalonic acidemia (HP:0002912)1.65356919
138Supernumerary bones of the axial skeleton (HP:0009144)1.65304398
139Hypobetalipoproteinemia (HP:0003563)1.64686469
140Papillary thyroid carcinoma (HP:0002895)1.64589539
141Abnormality of the duodenum (HP:0002246)1.64529085
142Cafe-au-lait spot (HP:0000957)1.64442753
143Exostoses (HP:0100777)1.64427752
144Abnormality of vitamin metabolism (HP:0100508)1.64231347
145Gastroesophageal reflux (HP:0002020)1.64068662
146Oligodactyly (HP:0012165)1.62571242
147Meckel diverticulum (HP:0002245)1.61859108
148Generalized hypopigmentation of hair (HP:0011358)1.61366860
149Progressive inability to walk (HP:0002505)1.61087756
150Abnormality of the preputium (HP:0100587)1.60905580
151Anteriorly placed anus (HP:0001545)1.60848413
152Ankle contracture (HP:0006466)1.60709703
153Hypoplasia of the maxilla (HP:0000327)1.60490891
154Pancreatic cysts (HP:0001737)1.60445542
155Abnormality of the metopic suture (HP:0005556)1.60378105
156Cerebral aneurysm (HP:0004944)1.60368125
157Obsessive-compulsive behavior (HP:0000722)1.60188673
158Drooling (HP:0002307)1.59897655
159Chromsome breakage (HP:0040012)1.59883095
160Symptomatic seizures (HP:0011145)1.59813356
161Abnormality of chromosome segregation (HP:0002916)1.59679781
162Myelodysplasia (HP:0002863)1.59272860
163Neoplasm of the rectum (HP:0100743)1.59069957
164Scrotal hypoplasia (HP:0000046)1.59035222
165Abnormality of the labia minora (HP:0012880)1.58832517
166Abnormality of the musculature of the pelvis (HP:0001469)1.58089175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.65647093
2CDK123.44482442
3TRIM283.06424861
4MST43.05527298
5NEK23.04419418
6BCR2.47084906
7WEE12.38068450
8LATS12.35207448
9MAP3K102.18588701
10PKN22.18197295
11TTK2.08748853
12PASK2.07285736
13MKNK21.99182181
14MKNK11.97263939
15BRD41.92618961
16BUB11.91484252
17STK391.89614559
18ACVR1B1.88666137
19RPS6KA41.88029119
20CDK61.85767898
21BRSK21.85510770
22TRIB31.83166870
23NEK11.76549671
24SCYL21.74245578
25CDK41.71722735
26STK31.62721048
27SRPK11.61273501
28STK101.61139995
29EEF2K1.58388639
30MAP4K21.55675506
31ATR1.48344275
32YES11.48049860
33TSSK61.46792537
34BMPR1B1.45157276
35MAP3K81.42497782
36SIK31.41944979
37FLT31.39773795
38AURKB1.39148177
39FRK1.37224108
40PLK11.36961932
41PLK31.36179239
42DYRK31.35094856
43PLK41.32743152
44MTOR1.29624852
45PTK61.28972188
46MAP3K41.28130802
47MET1.24199825
48NLK1.23739230
49CHEK11.23368916
50RPS6KB21.22528294
51OXSR11.22414731
52CDK71.21786431
53PLK21.18535845
54EPHA21.18492092
55EIF2AK11.18453204
56CAMK1D1.15983803
57PDGFRA1.15732759
58CHEK21.15691190
59TAF11.15688922
60STK41.09905143
61MAP3K21.09171901
62ALK1.06963994
63ATM1.06876776
64PAK41.06120764
65FGFR11.04151536
66TGFBR11.03282711
67FER0.99352095
68MELK0.96876724
69KSR10.93612143
70CDK20.90168114
71NUAK10.89363840
72BRSK10.87414178
73CAMK1G0.85550685
74PBK0.83900607
75LRRK20.81875003
76FGFR30.80760163
77CDK90.79961437
78BMPR20.79833584
79NEK90.76126225
80RPS6KB10.75742131
81CSNK1G10.75353251
82IRAK10.74983556
83EIF2AK20.74980243
84CASK0.71581669
85NEK60.71439719
86DYRK1B0.70087045
87PNCK0.69768395
88TNIK0.68660670
89EIF2AK30.68109225
90PAK30.67872399
91CDK10.67078603
92PIM10.65750405
93AKT30.64701711
94MAP4K10.63424114
95RIPK10.63358803
96JAK30.62991362
97PAK20.62598067
98CDK30.60706966
99WNK40.59075057
100MAP3K140.57047569
101SIK10.55793513
102PIK3CA0.54485767
103PRKDC0.52715984
104ERN10.52667886
105TAOK20.52019199
106CHUK0.51756411
107STK240.51579590
108PTK20.51378154
109EGFR0.50835743
110STK38L0.49368193
111CSNK1A1L0.48652912
112TESK20.48228073
113ZAP700.47861611
114MARK30.47851824
115CSNK1E0.47475225
116TTN0.47323319
117MAPK140.46997267
118CSNK1G30.46287471
119ZAK0.46007027
120ERBB40.45149096
121TAOK30.44773645
122PDGFRB0.44513552
123MAP2K30.44345729
124MAPK130.43472676
125ERBB30.42191597
126FGFR20.41926435
127TLK10.41872385
128AURKA0.41610134
129PRKCE0.41505319
130WNK30.40324197
131CSNK2A20.40157794
132SGK20.40148573
133CLK10.40073873
134CSNK1G20.39391440
135EPHA30.38678111
136FGR0.37681040
137HIPK20.36207310
138AKT10.35949606
139AKT20.35679240
140CSNK1D0.34706861
141FGFR40.33809087
142PRKCI0.33483836
143WNK10.32317700
144PRKAA20.31782428

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.31313418
2RNA transport_Homo sapiens_hsa030133.14560736
3Cell cycle_Homo sapiens_hsa041102.99467118
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.83305493
5Mismatch repair_Homo sapiens_hsa034302.78416116
6Spliceosome_Homo sapiens_hsa030402.71615633
7One carbon pool by folate_Homo sapiens_hsa006702.15797404
8Base excision repair_Homo sapiens_hsa034102.14095344
9* mRNA surveillance pathway_Homo sapiens_hsa030152.08632366
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06253860
11Propanoate metabolism_Homo sapiens_hsa006401.99531872
12Non-homologous end-joining_Homo sapiens_hsa034501.94616792
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93447101
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92811942
15Homologous recombination_Homo sapiens_hsa034401.79359530
16p53 signaling pathway_Homo sapiens_hsa041151.78379389
17Nucleotide excision repair_Homo sapiens_hsa034201.73664854
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.71591224
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61115452
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59787720
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58108132
22RNA degradation_Homo sapiens_hsa030181.55386951
23Fanconi anemia pathway_Homo sapiens_hsa034601.55070180
24Selenocompound metabolism_Homo sapiens_hsa004501.53679009
25Adherens junction_Homo sapiens_hsa045201.51301266
26Antigen processing and presentation_Homo sapiens_hsa046121.50730865
27MicroRNAs in cancer_Homo sapiens_hsa052061.49493438
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.49117581
29Circadian rhythm_Homo sapiens_hsa047101.46919287
30RNA polymerase_Homo sapiens_hsa030201.46118835
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45222714
32Small cell lung cancer_Homo sapiens_hsa052221.43534761
33Butanoate metabolism_Homo sapiens_hsa006501.39172715
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38747329
35Lysine degradation_Homo sapiens_hsa003101.35599207
36Chronic myeloid leukemia_Homo sapiens_hsa052201.35003098
37Viral carcinogenesis_Homo sapiens_hsa052031.33907909
38mTOR signaling pathway_Homo sapiens_hsa041501.29622221
39Regulation of autophagy_Homo sapiens_hsa041401.28043507
40HTLV-I infection_Homo sapiens_hsa051661.27516533
41Steroid biosynthesis_Homo sapiens_hsa001001.27243097
42Thyroid cancer_Homo sapiens_hsa052161.24942881
43Herpes simplex infection_Homo sapiens_hsa051681.16803487
44Epstein-Barr virus infection_Homo sapiens_hsa051691.16776843
45Pyrimidine metabolism_Homo sapiens_hsa002401.16561714
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16232326
47Prostate cancer_Homo sapiens_hsa052151.14457290
48Basal transcription factors_Homo sapiens_hsa030221.12460249
49Oocyte meiosis_Homo sapiens_hsa041141.11906546
50Fatty acid metabolism_Homo sapiens_hsa012121.09736671
51Colorectal cancer_Homo sapiens_hsa052101.09342728
52Basal cell carcinoma_Homo sapiens_hsa052171.08625478
53Hippo signaling pathway_Homo sapiens_hsa043901.07031450
54TGF-beta signaling pathway_Homo sapiens_hsa043501.03159065
55Inositol phosphate metabolism_Homo sapiens_hsa005620.95106007
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92584280
57Proteoglycans in cancer_Homo sapiens_hsa052050.91722818
58Fatty acid elongation_Homo sapiens_hsa000620.90733280
59Notch signaling pathway_Homo sapiens_hsa043300.88441446
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88348509
61Endometrial cancer_Homo sapiens_hsa052130.87924008
62Pancreatic cancer_Homo sapiens_hsa052120.85112485
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84304079
64Systemic lupus erythematosus_Homo sapiens_hsa053220.83281701
65Dorso-ventral axis formation_Homo sapiens_hsa043200.83164874
66Hepatitis B_Homo sapiens_hsa051610.81121521
67Fatty acid biosynthesis_Homo sapiens_hsa000610.80808428
68Hedgehog signaling pathway_Homo sapiens_hsa043400.78947355
69Viral myocarditis_Homo sapiens_hsa054160.77861454
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76486502
71Bladder cancer_Homo sapiens_hsa052190.76460028
72FoxO signaling pathway_Homo sapiens_hsa040680.74451316
73Acute myeloid leukemia_Homo sapiens_hsa052210.73714628
74Pathways in cancer_Homo sapiens_hsa052000.73506796
75Non-small cell lung cancer_Homo sapiens_hsa052230.72682745
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.68744246
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68575658
78N-Glycan biosynthesis_Homo sapiens_hsa005100.67972045
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66436401
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.66280451
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66056348
82Insulin resistance_Homo sapiens_hsa049310.65913561
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65688064
84Glucagon signaling pathway_Homo sapiens_hsa049220.64986796
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64182661
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.62886075
87Focal adhesion_Homo sapiens_hsa045100.60239529
88Legionellosis_Homo sapiens_hsa051340.60063629
89Wnt signaling pathway_Homo sapiens_hsa043100.59321091
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.56084834
91Ribosome_Homo sapiens_hsa030100.55895604
92Ether lipid metabolism_Homo sapiens_hsa005650.55236499
93Fatty acid degradation_Homo sapiens_hsa000710.54439449
94Apoptosis_Homo sapiens_hsa042100.54320402
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53255341
96beta-Alanine metabolism_Homo sapiens_hsa004100.52187885
97Measles_Homo sapiens_hsa051620.51867790
98Sphingolipid metabolism_Homo sapiens_hsa006000.51704057
99Toxoplasmosis_Homo sapiens_hsa051450.50478750
100Purine metabolism_Homo sapiens_hsa002300.50158779
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49279455
102Primary immunodeficiency_Homo sapiens_hsa053400.49199160
103AMPK signaling pathway_Homo sapiens_hsa041520.49104011
104Influenza A_Homo sapiens_hsa051640.47741865
105Tight junction_Homo sapiens_hsa045300.46830916
106HIF-1 signaling pathway_Homo sapiens_hsa040660.46517689
107Renal cell carcinoma_Homo sapiens_hsa052110.46155937
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45009255
109Protein export_Homo sapiens_hsa030600.44884096
110T cell receptor signaling pathway_Homo sapiens_hsa046600.44464931
111Shigellosis_Homo sapiens_hsa051310.44137874
112Folate biosynthesis_Homo sapiens_hsa007900.43791343
113B cell receptor signaling pathway_Homo sapiens_hsa046620.43418561
114Phototransduction_Homo sapiens_hsa047440.42544946
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42419613
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.41421085
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40826859
118Caffeine metabolism_Homo sapiens_hsa002320.40750272
119Renin-angiotensin system_Homo sapiens_hsa046140.40622062
120Prolactin signaling pathway_Homo sapiens_hsa049170.40591759
121Insulin signaling pathway_Homo sapiens_hsa049100.40403324
122Peroxisome_Homo sapiens_hsa041460.39269970
123Proteasome_Homo sapiens_hsa030500.38093387
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38083363
125Melanoma_Homo sapiens_hsa052180.37805293
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36874407
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36501597
128Glioma_Homo sapiens_hsa052140.36475622
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.36244533
130Vitamin B6 metabolism_Homo sapiens_hsa007500.35964408
131Pyruvate metabolism_Homo sapiens_hsa006200.34162382
132Choline metabolism in cancer_Homo sapiens_hsa052310.33731963
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33199303
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32505077
135Long-term depression_Homo sapiens_hsa047300.31989961
136Type II diabetes mellitus_Homo sapiens_hsa049300.31338500
137ErbB signaling pathway_Homo sapiens_hsa040120.29483685

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