PANK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.21662980
2nuclear pore complex assembly (GO:0051292)7.01380686
3nuclear pore organization (GO:0006999)6.10608785
4regulation of sequestering of triglyceride (GO:0010889)6.02612022
5triglyceride catabolic process (GO:0019433)5.57134115
6positive regulation of fatty acid beta-oxidation (GO:0032000)5.22842011
7neutral lipid catabolic process (GO:0046461)5.13562840
8acylglycerol catabolic process (GO:0046464)5.13562840
9white fat cell differentiation (GO:0050872)5.09119333
10biotin metabolic process (GO:0006768)5.04019661
11triglyceride biosynthetic process (GO:0019432)4.94732479
12pore complex assembly (GO:0046931)4.92953977
13alpha-linolenic acid metabolic process (GO:0036109)4.85727658
14acylglycerol biosynthetic process (GO:0046463)4.75899381
15neutral lipid biosynthetic process (GO:0046460)4.75899381
16positive regulation of fatty acid oxidation (GO:0046321)4.72472021
17regulation of cholesterol storage (GO:0010885)4.48110660
18regulation of NFAT protein import into nucleus (GO:0051532)4.40394094
19fatty acid transmembrane transport (GO:1902001)4.36489579
20brown fat cell differentiation (GO:0050873)4.33017994
21mitotic sister chromatid cohesion (GO:0007064)4.32604687
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.23804378
23fatty-acyl-CoA biosynthetic process (GO:0046949)4.22107141
24negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.21636813
25valine metabolic process (GO:0006573)4.19341090
26regulation of fatty acid beta-oxidation (GO:0031998)4.18431031
27pre-miRNA processing (GO:0031054)4.07017346
28cytoplasmic mRNA processing body assembly (GO:0033962)3.99807479
29regulation of RNA export from nucleus (GO:0046831)3.98421767
30triglyceride metabolic process (GO:0006641)3.95045764
31growth hormone receptor signaling pathway (GO:0060396)3.94091437
32positive regulation of cellular response to insulin stimulus (GO:1900078)3.92866214
33carnitine shuttle (GO:0006853)3.90637865
34glycerolipid catabolic process (GO:0046503)3.88968857
35plasma lipoprotein particle clearance (GO:0034381)3.88242554
36acyl-CoA biosynthetic process (GO:0071616)3.87358693
37thioester biosynthetic process (GO:0035384)3.87358693
38fatty acid homeostasis (GO:0055089)3.85671654
39long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.77379428
40acylglycerol metabolic process (GO:0006639)3.76139540
41positive regulation of lipid catabolic process (GO:0050996)3.75552517
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.70306388
43neutral lipid metabolic process (GO:0006638)3.69453173
44fatty-acyl-CoA metabolic process (GO:0035337)3.63638189
45negative regulation of DNA repair (GO:0045738)3.62512038
46embryonic process involved in female pregnancy (GO:0060136)3.52312209
47DNA unwinding involved in DNA replication (GO:0006268)3.48829449
48positive regulation of fatty acid metabolic process (GO:0045923)3.46524582
49paraxial mesoderm development (GO:0048339)3.46165757
50fatty acid beta-oxidation (GO:0006635)3.41764526
51regulation of nucleobase-containing compound transport (GO:0032239)3.38181650
52cellular response to growth hormone stimulus (GO:0071378)3.37188612
53positive regulation of glucose import (GO:0046326)3.35409586
54regulation of fatty acid oxidation (GO:0046320)3.32342021
55acetyl-CoA metabolic process (GO:0006084)3.30870281
56regulation of sister chromatid cohesion (GO:0007063)3.30131337
57CDP-diacylglycerol biosynthetic process (GO:0016024)3.28998571
58fatty acid oxidation (GO:0019395)3.25402363
59gastrulation with mouth forming second (GO:0001702)3.24920570
60acylglycerol homeostasis (GO:0055090)3.24783578
61triglyceride homeostasis (GO:0070328)3.24783578
62triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21777220
63intracellular lipid transport (GO:0032365)3.21572908
64sulfur amino acid catabolic process (GO:0000098)3.20997717
65lipid oxidation (GO:0034440)3.18588245
66mitotic chromosome condensation (GO:0007076)3.17425480
67iron ion import (GO:0097286)3.17136175
68negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.16282703
69CDP-diacylglycerol metabolic process (GO:0046341)3.15592273
70embryonic camera-type eye morphogenesis (GO:0048596)3.15013493
71positive regulation of insulin receptor signaling pathway (GO:0046628)3.14602131
72lipid particle organization (GO:0034389)3.14461707
73regulation of macrophage derived foam cell differentiation (GO:0010743)3.14203030
74regulation of glucose import in response to insulin stimulus (GO:2001273)3.10830901
75response to lipoprotein particle (GO:0055094)3.06559495
76retina vasculature morphogenesis in camera-type eye (GO:0061299)3.05552197
77regulation of triglyceride catabolic process (GO:0010896)3.05007658
78negative regulation of lipid storage (GO:0010888)3.04707717
79peptidyl-lysine dimethylation (GO:0018027)3.04353830
80positive regulation of glycolytic process (GO:0045821)3.03275612
81fatty acid catabolic process (GO:0009062)3.03051830
82carnitine transmembrane transport (GO:1902603)2.99079123
83regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.98482960
84regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94904037
85morphogenesis of an epithelial sheet (GO:0002011)2.94707532
86response to dietary excess (GO:0002021)2.94573437
87positive regulation of glycogen biosynthetic process (GO:0045725)2.94501884
88embryonic retina morphogenesis in camera-type eye (GO:0060059)2.93001743
89positive regulation of glucose transport (GO:0010828)2.92906487
90positive regulation of lipid storage (GO:0010884)2.92113556
91complement activation, alternative pathway (GO:0006957)2.89650593
92protein heterotrimerization (GO:0070208)2.89137593
93linoleic acid metabolic process (GO:0043651)2.88756954
94embryonic foregut morphogenesis (GO:0048617)2.88204962
95regulation of cholesterol homeostasis (GO:2000188)2.86836834
96insulin-like growth factor receptor signaling pathway (GO:0048009)2.86516041
97NLS-bearing protein import into nucleus (GO:0006607)2.86507579
98sister chromatid segregation (GO:0000819)2.86295901
99cellular response to lithium ion (GO:0071285)2.83815408
100cytoskeletal anchoring at plasma membrane (GO:0007016)2.83308107
101carnitine transport (GO:0015879)2.82387242
102amino-acid betaine transport (GO:0015838)2.82387242
103intestinal absorption (GO:0050892)2.81612075
104negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.81158448
105protein localization to microtubule (GO:0035372)2.80417755
106phospholipid homeostasis (GO:0055091)2.79923092
107regulation of cAMP-dependent protein kinase activity (GO:2000479)2.79889277
108epoxygenase P450 pathway (GO:0019373)2.79884444
109positive regulation of triglyceride metabolic process (GO:0090208)2.79860242
110negative regulation of keratinocyte proliferation (GO:0010839)2.79595759
111regulation of transforming growth factor beta2 production (GO:0032909)2.77926508
112ovulation from ovarian follicle (GO:0001542)2.77474253
113COPII vesicle coating (GO:0048208)2.77406381
114negative regulation of dendrite morphogenesis (GO:0050774)2.77026653
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76998462
116lipoprotein transport (GO:0042953)2.76952341
117ectodermal placode formation (GO:0060788)2.75433317
118establishment of nucleus localization (GO:0040023)2.73306744
119regulation of lipid catabolic process (GO:0050994)2.71797944
120RNA stabilization (GO:0043489)2.70429228
121mRNA stabilization (GO:0048255)2.70429228
122desmosome organization (GO:0002934)2.68597077
123lipid storage (GO:0019915)2.68303045
124bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66659336
125layer formation in cerebral cortex (GO:0021819)2.66063267
126midgut development (GO:0007494)2.65750793
127cellular response to vitamin (GO:0071295)2.65371444
128regulation of centriole replication (GO:0046599)2.65337362
129negative regulation of fatty acid biosynthetic process (GO:0045717)2.64995171
130positive regulation of sterol transport (GO:0032373)2.64571650
131positive regulation of cholesterol transport (GO:0032376)2.64571650
132transcytosis (GO:0045056)2.64550060
133hippo signaling (GO:0035329)2.63937913
134diacylglycerol metabolic process (GO:0046339)2.63917354
135NADPH regeneration (GO:0006740)2.63534970
136positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60850140
137positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60850140
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.60850140
139regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60243863
140pantothenate metabolic process (GO:0015939)2.60223228
141cysteine metabolic process (GO:0006534)2.60054569
142dorsal/ventral axis specification (GO:0009950)2.57812862
143positive regulation of histone deacetylation (GO:0031065)2.57661657
144DNA duplex unwinding (GO:0032508)2.57208112
145embryonic eye morphogenesis (GO:0048048)2.55048558
146positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52501192
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.52399950
148DNA topological change (GO:0006265)2.50640932
149COPI coating of Golgi vesicle (GO:0048205)2.50227945
150Golgi transport vesicle coating (GO:0048200)2.50227945
151cellular protein complex localization (GO:0034629)2.48133756
152apical protein localization (GO:0045176)2.46064719
153positive regulation of catenin import into nucleus (GO:0035413)2.45771776
154negative regulation of fatty acid transport (GO:2000192)2.44859799
155negative regulation of neurotransmitter secretion (GO:0046929)2.44657282
156peptidyl-threonine modification (GO:0018210)2.44224470
157DNA geometric change (GO:0032392)2.44031995
158mitotic cytokinesis (GO:0000281)2.41362660
159histone H3-K9 demethylation (GO:0033169)2.38818770
160notochord development (GO:0030903)2.38079380
161hemidesmosome assembly (GO:0031581)2.37461749
162protein localization to chromosome, centromeric region (GO:0071459)2.37392980
163gap junction assembly (GO:0016264)2.37184046
164protein export from nucleus (GO:0006611)2.36981092
165positive regulation of dendritic spine morphogenesis (GO:0061003)2.36787742
166regulation of Rac protein signal transduction (GO:0035020)2.36138957
167monoubiquitinated protein deubiquitination (GO:0035520)2.33892912
168positive regulation of cell cycle checkpoint (GO:1901978)2.33307295
169double-strand break repair via nonhomologous end joining (GO:0006303)2.32595166
170non-recombinational repair (GO:0000726)2.32595166
171labyrinthine layer development (GO:0060711)2.32547692
172cytoskeleton-dependent cytokinesis (GO:0061640)2.32427353
173histone lysine demethylation (GO:0070076)2.32143362
174peptidyl-threonine phosphorylation (GO:0018107)2.32123454
175nerve growth factor signaling pathway (GO:0038180)2.32071307
176positive regulation of chromosome segregation (GO:0051984)2.28724877
177mitotic sister chromatid segregation (GO:0000070)2.27596495
178regulation of cardioblast differentiation (GO:0051890)2.26589218
179asymmetric protein localization (GO:0008105)2.26176040
180regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.25761401
181vesicle coating (GO:0006901)2.24805203
182protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.22520667
183establishment of spindle orientation (GO:0051294)2.21899284
184histone H3-K36 demethylation (GO:0070544)2.20306573
185protein complex localization (GO:0031503)2.18287655
186nucleus localization (GO:0051647)2.16987576
187negative regulation of histone methylation (GO:0031061)2.16457984
188urea cycle (GO:0000050)2.16427241
189genitalia morphogenesis (GO:0035112)2.15979239
190regulation of centrosome duplication (GO:0010824)2.15344929
191regulation of mitotic spindle organization (GO:0060236)2.13664683
192regulation of translational fidelity (GO:0006450)2.13376773
193heart morphogenesis (GO:0003007)2.13095461
194response to epidermal growth factor (GO:0070849)2.12678171
195very-low-density lipoprotein particle assembly (GO:0034379)2.12100633
196histone demethylation (GO:0016577)2.10550032
197urea metabolic process (GO:0019627)2.10253154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.93651802
2E2F7_22180533_ChIP-Seq_HELA_Human5.58928856
3CLOCK_20551151_ChIP-Seq_293T_Human4.13565203
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.10764744
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77717549
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.55723525
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.47383352
8* RXR_22158963_ChIP-Seq_LIVER_Mouse3.27080376
9* LXR_22158963_ChIP-Seq_LIVER_Mouse3.17889280
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73312794
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72505515
12ZNF263_19887448_ChIP-Seq_K562_Human2.72412370
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65052113
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56259292
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.54232299
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.19889082
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15699043
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.12587897
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.08124282
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98613831
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94897363
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.94853221
23* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.87940068
24AR_21909140_ChIP-Seq_LNCAP_Human1.83175988
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81094530
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74024347
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69993850
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69750865
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68694500
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60726885
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58249360
32* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.55628721
33YAP1_20516196_ChIP-Seq_MESCs_Mouse1.53812809
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.53533998
35TAF15_26573619_Chip-Seq_HEK293_Human1.52895648
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52309843
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.48462363
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.48243068
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45639906
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.45044048
41FUS_26573619_Chip-Seq_HEK293_Human1.44560215
42CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41729533
43* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39954852
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38413462
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37594764
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.37312185
47* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34883718
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.34849181
49RXR_22108803_ChIP-Seq_LS180_Human1.32389246
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.31253166
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.30953618
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.29464122
53* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27820120
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26710507
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26514426
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26491939
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24991867
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24840407
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24770963
60* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23891555
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23092226
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21795216
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21795216
64CJUN_26792858_Chip-Seq_BT549_Human1.20909605
65FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20341306
66* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20251285
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20103089
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19593586
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18526159
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18486934
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18213087
72GATA4_25053715_ChIP-Seq_YYC3_Human1.17068299
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16132057
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.15183925
75FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14914036
76* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14071101
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13660309
78TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12469101
79TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11812126
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11433937
81TP53_16413492_ChIP-PET_HCT116_Human1.10416521
82SOX2_20726797_ChIP-Seq_SW620_Human1.10220097
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10154496
84TP63_19390658_ChIP-ChIP_HaCaT_Human1.10140069
85SOX9_26525672_Chip-Seq_HEART_Mouse1.10121074
86GBX2_23144817_ChIP-Seq_PC3_Human1.09263486
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09154598
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08435738
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08163146
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08035388
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.07633203
92BRD4_25478319_ChIP-Seq_HGPS_Human1.07051978
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06063486
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05235551
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05169304
96* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03941675
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03575829
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01888919
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.00853341
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98851031
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98769566
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98769566
103HNF4A_19822575_ChIP-Seq_HepG2_Human0.98161865
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98088756
105AHR_22903824_ChIP-Seq_MCF-7_Human0.95774756
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95582724
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.95208438
108PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94395750
109AR_21572438_ChIP-Seq_LNCaP_Human0.94350695
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93769383
111GATA1_22025678_ChIP-Seq_K562_Human0.93715057
112CHD1_26751641_Chip-Seq_LNCaP_Human0.93445620
113BCAT_22108803_ChIP-Seq_LS180_Human0.93438457
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.93428080
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93282379
116TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93222271
117SMAD4_21799915_ChIP-Seq_A2780_Human0.93076945
118* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92592578
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.92023483
120NANOG_21062744_ChIP-ChIP_HESCs_Human0.90833788
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.90328405
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90297029
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90273284
124GATA6_25053715_ChIP-Seq_YYC3_Human0.89895188
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89302787
126GF1B_26923725_Chip-Seq_HPCs_Mouse0.87700645
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87560159
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86881948
129NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86821640
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86630939
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86550335
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86279723
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86031008
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.85910756
135CDX2_22108803_ChIP-Seq_LS180_Human0.85588620
136ATF3_27146783_Chip-Seq_COLON_Human0.85214282
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.84863221
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84679718
139* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83720457
140FOXM1_23109430_ChIP-Seq_U2OS_Human0.82735893
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.82295381
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.82295381
143RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81607252
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81433300
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81181530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.03152922
2MP0004185_abnormal_adipocyte_glucose4.66811626
3MP0005666_abnormal_adipose_tissue4.48231230
4MP0004130_abnormal_muscle_cell3.98764043
5MP0008057_abnormal_DNA_replication3.80325395
6MP0008438_abnormal_cutaneous_collagen3.53263421
7MP0003705_abnormal_hypodermis_morpholog3.46008846
8MP0002139_abnormal_hepatobiliary_system3.37333153
9MP0010234_abnormal_vibrissa_follicle3.31691356
10MP0005375_adipose_tissue_phenotype3.27561351
11MP0005360_urolithiasis3.09496423
12MP0010329_abnormal_lipoprotein_level2.91900881
13MP0000013_abnormal_adipose_tissue2.81160547
14MP0003890_abnormal_embryonic-extraembry2.79986161
15MP0001661_extended_life_span2.78294444
16MP0005365_abnormal_bile_salt2.69720176
17MP0005409_darkened_coat_color2.58482426
18MP0000003_abnormal_adipose_tissue2.52147584
19MP0003941_abnormal_skin_development2.50173687
20MP0002971_abnormal_brown_adipose2.33056174
21MP0009780_abnormal_chondrocyte_physiolo2.23297488
22MP0005275_abnormal_skin_tensile2.16244359
23MP0000566_synostosis2.16145010
24MP0009115_abnormal_fat_cell2.01819178
25MP0002118_abnormal_lipid_homeostasis1.97479790
26MP0005334_abnormal_fat_pad1.94073833
27MP0002697_abnormal_eye_size1.92744934
28MP0004272_abnormal_basement_membrane1.84776575
29MP0003191_abnormal_cellular_cholesterol1.83254938
30MP0002876_abnormal_thyroid_physiology1.74424455
31MP0005085_abnormal_gallbladder_physiolo1.67098080
32MP0003252_abnormal_bile_duct1.62652012
33MP0005076_abnormal_cell_differentiation1.60718256
34MP0000609_abnormal_liver_physiology1.57395294
35MP0002009_preneoplasia1.55643141
36MP0004957_abnormal_blastocyst_morpholog1.53846635
37MP0002084_abnormal_developmental_patter1.53421139
38MP0005380_embryogenesis_phenotype1.52791575
39MP0001672_abnormal_embryogenesis/_devel1.52791575
40MP0001730_embryonic_growth_arrest1.48483635
41MP0000778_abnormal_nervous_system1.48371160
42MP0002086_abnormal_extraembryonic_tissu1.46480427
43MP0001881_abnormal_mammary_gland1.42305479
44MP0002970_abnormal_white_adipose1.41978692
45MP0003077_abnormal_cell_cycle1.41493544
46MP0002837_dystrophic_cardiac_calcinosis1.40402315
47MP0009697_abnormal_copulation1.39555835
48MP0004270_analgesia1.37646174
49MP0002092_abnormal_eye_morphology1.36809815
50MP0010678_abnormal_skin_adnexa1.35403416
51MP0003690_abnormal_glial_cell1.33655068
52MP0003935_abnormal_craniofacial_develop1.33430220
53MP0000579_abnormal_nail_morphology1.32003497
54MP0001666_abnormal_nutrient_absorption1.31067800
55MP0001915_intracranial_hemorrhage1.30496495
56MP0003300_gastrointestinal_ulcer1.29661303
57MP0003111_abnormal_nucleus_morphology1.29253885
58MP0003385_abnormal_body_wall1.28160877
59MP0010352_gastrointestinal_tract_polyps1.27370905
60MP0002085_abnormal_embryonic_tissue1.25346514
61MP0001286_abnormal_eye_development1.23946658
62MP0005448_abnormal_energy_balance1.23747387
63MP0002877_abnormal_melanocyte_morpholog1.23178833
64MP0010307_abnormal_tumor_latency1.21650598
65MP0009672_abnormal_birth_weight1.20348408
66MP0000350_abnormal_cell_proliferation1.20025444
67MP0010094_abnormal_chromosome_stability1.18241365
68MP0001697_abnormal_embryo_size1.17410110
69MP0000534_abnormal_ureter_morphology1.16432573
70MP0003045_fibrosis1.16194950
71MP0003115_abnormal_respiratory_system1.14551439
72MP0001293_anophthalmia1.12670853
73MP0009384_cardiac_valve_regurgitation1.12087541
74MP0000427_abnormal_hair_cycle1.11926751
75MP0002822_catalepsy1.11366023
76MP0003861_abnormal_nervous_system1.10347074
77MP0002078_abnormal_glucose_homeostasis1.09286461
78MP0009840_abnormal_foam_cell1.08796344
79MP0002166_altered_tumor_susceptibility1.07746203
80MP0003567_abnormal_fetal_cardiomyocyte1.07021802
81MP0000377_abnormal_hair_follicle1.05846593
82MP0008932_abnormal_embryonic_tissue1.03920720
83MP0000569_abnormal_digit_pigmentation1.03114717
84MP0003693_abnormal_embryo_hatching1.01137708
85MP0001299_abnormal_eye_distance/1.01037393
86MP0002098_abnormal_vibrissa_morphology1.00530346
87MP0002060_abnormal_skin_morphology1.00475403
88MP0002909_abnormal_adrenal_gland1.00120294
89MP0000432_abnormal_head_morphology0.99813960
90MP0005257_abnormal_intraocular_pressure0.99171711
91MP0002080_prenatal_lethality0.99016536
92MP0005187_abnormal_penis_morphology0.98804524
93MP0001177_atelectasis0.97322826
94MP0005332_abnormal_amino_acid0.96919414
95MP0003959_abnormal_lean_body0.96249457
96MP0009703_decreased_birth_body0.95824523
97MP0005535_abnormal_body_temperature0.95104777
98MP0002796_impaired_skin_barrier0.94761527
99MP0000647_abnormal_sebaceous_gland0.94607333
100MP0003942_abnormal_urinary_system0.93546988
101MP0002081_perinatal_lethality0.93219183
102MP0008875_abnormal_xenobiotic_pharmacok0.91431454
103MP0006138_congestive_heart_failure0.90488796
104MP0000462_abnormal_digestive_system0.90460658
105MP0002396_abnormal_hematopoietic_system0.89549342
106MP0004233_abnormal_muscle_weight0.89426744
107MP0002233_abnormal_nose_morphology0.89016825
108MP0003119_abnormal_digestive_system0.87909851
109MP0003221_abnormal_cardiomyocyte_apopto0.87422846
110MP0003123_paternal_imprinting0.86291589
111MP0003315_abnormal_perineum_morphology0.85060705
112MP0005501_abnormal_skin_physiology0.85038784
113MP0010630_abnormal_cardiac_muscle0.84979955
114MP0005452_abnormal_adipose_tissue0.84197152
115MP0005248_abnormal_Harderian_gland0.84088842
116MP0002896_abnormal_bone_mineralization0.83703965
117MP0005197_abnormal_uvea_morphology0.83395283
118MP0002168_other_aberrant_phenotype0.82508005
119MP0001346_abnormal_lacrimal_gland0.82476677
120MP0001188_hyperpigmentation0.82400562
121MP0000762_abnormal_tongue_morphology0.82136672
122MP0002925_abnormal_cardiovascular_devel0.80438615
123MP0002111_abnormal_tail_morphology0.79990968
124MP0001756_abnormal_urination0.79831521
125MP0003755_abnormal_palate_morphology0.79479800
126MP0003950_abnormal_plasma_membrane0.78551812
127MP0002184_abnormal_innervation0.76814338
128MP0003943_abnormal_hepatobiliary_system0.76684291
129MP0002254_reproductive_system_inflammat0.76130494
130MP0000537_abnormal_urethra_morphology0.76110665
131MP0003091_abnormal_cell_migration0.75293682
132MP0003937_abnormal_limbs/digits/tail_de0.75206517
133MP0004197_abnormal_fetal_growth/weight/0.74562687
134MP0000627_abnormal_mammary_gland0.74500964
135MP0003566_abnormal_cell_adhesion0.72036133
136MP0003632_abnormal_nervous_system0.71647443
137MP0004264_abnormal_extraembryonic_tissu0.69648737
138MP0002006_tumorigenesis0.68990979
139MP0009053_abnormal_anal_canal0.65549870
140MP0005647_abnormal_sex_gland0.64803773
141MP0003283_abnormal_digestive_organ0.64351062
142MP0000733_abnormal_muscle_development0.64322965
143MP0001849_ear_inflammation0.64005603
144MP0003868_abnormal_feces_composition0.63529709
145MP0000383_abnormal_hair_follicle0.63402234
146MP0005379_endocrine/exocrine_gland_phen0.61515496
147MP0003953_abnormal_hormone_level0.61241399
148MP0005319_abnormal_enzyme/_coenzyme0.60061042
149MP0009643_abnormal_urine_homeostasis0.59816983
150MP0001944_abnormal_pancreas_morphology0.59788254
151MP0001727_abnormal_embryo_implantation0.56961484
152MP0000598_abnormal_liver_morphology0.56380698
153MP0003828_pulmonary_edema0.55932037
154MP0000428_abnormal_craniofacial_morphol0.55510983
155MP0004019_abnormal_vitamin_homeostasis0.52531294
156MP0005220_abnormal_exocrine_pancreas0.52376638
157MP0002088_abnormal_embryonic_growth/wei0.51405496
158MP0005451_abnormal_body_composition0.49993770
159MP0003453_abnormal_keratinocyte_physiol0.49798414
160MP0003984_embryonic_growth_retardation0.49728770

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)4.55281192
2Hyperglycinuria (HP:0003108)4.51376287
3Acanthosis nigricans (HP:0000956)4.03386734
4Abnormality of glycine metabolism (HP:0010895)4.01688130
5Abnormality of serine family amino acid metabolism (HP:0010894)4.01688130
6Epidermoid cyst (HP:0200040)3.98422238
7Hyperglycinemia (HP:0002154)3.67470443
8Insulin-resistant diabetes mellitus (HP:0000831)3.64820472
9Xanthomatosis (HP:0000991)3.37145934
10Hyperglycemia (HP:0003074)3.35315781
11Ankle contracture (HP:0006466)3.26981611
12Hypoalphalipoproteinemia (HP:0003233)3.22120975
13Asymmetry of the thorax (HP:0001555)3.20570810
14Myocardial infarction (HP:0001658)3.15730363
15Enlarged penis (HP:0000040)3.01698387
16Insidious onset (HP:0003587)3.01664548
17Termporal pattern (HP:0011008)3.01664548
18Hyperlipoproteinemia (HP:0010980)2.99449357
19Subcapsular cataract (HP:0000523)2.92687023
20Hypertriglyceridemia (HP:0002155)2.86226284
21Complement deficiency (HP:0004431)2.81860132
22Hypoglycemic coma (HP:0001325)2.76771940
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.76378675
24Macroorchidism (HP:0000053)2.76023875
25Hepatoblastoma (HP:0002884)2.73457781
26Premature rupture of membranes (HP:0001788)2.69377305
27Skin nodule (HP:0200036)2.69074802
28Abnormal cartilage morphology (HP:0002763)2.66684167
29Thyroid carcinoma (HP:0002890)2.66606260
30Curly hair (HP:0002212)2.55812797
31Insulin resistance (HP:0000855)2.52262733
32Hypolipoproteinemia (HP:0010981)2.47449108
33Rectal prolapse (HP:0002035)2.46027783
34Cerebral aneurysm (HP:0004944)2.43489104
35Neoplasm of the adrenal cortex (HP:0100641)2.43118320
36Missing ribs (HP:0000921)2.40923837
37Pigmentary retinal degeneration (HP:0001146)2.39093332
38Shallow orbits (HP:0000586)2.39019324
39Leiomyosarcoma (HP:0100243)2.37678683
40Uterine leiomyosarcoma (HP:0002891)2.37678683
41Ankyloglossia (HP:0010296)2.37648119
42Flat acetabular roof (HP:0003180)2.37194422
43Ketoacidosis (HP:0001993)2.35595725
44Deep venous thrombosis (HP:0002625)2.35302305
45Subacute progressive viral hepatitis (HP:0006572)2.34946707
46Hemorrhage of the eye (HP:0011885)2.33007628
47Gastrointestinal carcinoma (HP:0002672)2.32822634
48Malignant gastrointestinal tract tumors (HP:0006749)2.32822634
49Increased nuchal translucency (HP:0010880)2.30511215
50Osteolytic defects of the hand bones (HP:0009699)2.30014367
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.30014367
52Turricephaly (HP:0000262)2.28778248
53Transitional cell carcinoma of the bladder (HP:0006740)2.28292801
54Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.28285878
55Hyperthyroidism (HP:0000836)2.28052204
56Deep philtrum (HP:0002002)2.27222176
57Hematochezia (HP:0002573)2.26687522
58Abnormality of proline metabolism (HP:0010907)2.22610914
59Hydroxyprolinuria (HP:0003080)2.22610914
60Lymphangioma (HP:0100764)2.22426396
61Difficulty running (HP:0009046)2.21817363
62Follicular hyperkeratosis (HP:0007502)2.21161602
63Ketosis (HP:0001946)2.20250233
64Vertebral arch anomaly (HP:0008438)2.18283930
65Reduced subcutaneous adipose tissue (HP:0003758)2.17453954
66Right ventricular cardiomyopathy (HP:0011663)2.17290373
67Large earlobe (HP:0009748)2.14815155
68Bladder carcinoma (HP:0002862)2.14599686
69Bladder neoplasm (HP:0009725)2.14599686
70Pheochromocytoma (HP:0002666)2.12695442
71Abnormality of the distal phalanx of the thumb (HP:0009617)2.10480757
72Sandal gap (HP:0001852)2.09101539
73Cupped ribs (HP:0000887)2.08753440
74Mitral valve prolapse (HP:0001634)2.08138968
75Dysmetric saccades (HP:0000641)2.05253441
76Visceral angiomatosis (HP:0100761)2.05181949
77Neonatal hypoglycemia (HP:0001998)2.05119146
78High anterior hairline (HP:0009890)2.05087724
79Buphthalmos (HP:0000557)2.04941836
80Ileus (HP:0002595)2.03091358
81Hyperacusis (HP:0010780)2.02644069
82Exostoses (HP:0100777)2.02260543
83Nephroblastoma (Wilms tumor) (HP:0002667)2.01677808
84Cortical dysplasia (HP:0002539)2.01452082
85Abnormality of purine metabolism (HP:0004352)2.00092474
86Cystic hygroma (HP:0000476)1.99964637
87Abnormality of glutamine family amino acid metabolism (HP:0010902)1.98350590
88Cubitus valgus (HP:0002967)1.98133778
89Hemangiomatosis (HP:0007461)1.97574221
90Embryonal renal neoplasm (HP:0011794)1.96057031
91Germ cell neoplasia (HP:0100728)1.95988550
92Midline defect of the nose (HP:0004122)1.95909319
93Medulloblastoma (HP:0002885)1.95717089
94Renovascular hypertension (HP:0100817)1.92628601
95Overgrowth (HP:0001548)1.91203977
96Overlapping toe (HP:0001845)1.88640553
97Hypercholesterolemia (HP:0003124)1.88152064
98Obsessive-compulsive behavior (HP:0000722)1.87923231
99Hyperammonemia (HP:0001987)1.87071405
100Intrahepatic cholestasis (HP:0001406)1.87049915
101Cutaneous finger syndactyly (HP:0010554)1.86831139
102Abnormal foot bone ossification (HP:0010675)1.86488169
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85092291
104Short 4th metacarpal (HP:0010044)1.85092291
105Hammertoe (HP:0001765)1.84685514
106Skull defect (HP:0001362)1.84636766
107Increased connective tissue (HP:0009025)1.84373279
108Acute myeloid leukemia (HP:0004808)1.82824508
109Venous abnormality (HP:0002624)1.81932892
110Hypoglycemic seizures (HP:0002173)1.80913236
111Cutaneous syndactyly (HP:0012725)1.80761887
112Multiple enchondromatosis (HP:0005701)1.79603811
113Abnormality of chromosome segregation (HP:0002916)1.78048276
114Drooling (HP:0002307)1.77863711
115Papillary thyroid carcinoma (HP:0002895)1.76798279
116Hamartoma of the eye (HP:0010568)1.72625093
117Spinal cord lesions (HP:0100561)1.72275114
118Syringomyelia (HP:0003396)1.72275114
119Volvulus (HP:0002580)1.72194457
120Oligodactyly (hands) (HP:0001180)1.72123401
121Aplasia involving bones of the extremities (HP:0009825)1.70706558
122Aplasia involving bones of the upper limbs (HP:0009823)1.70706558
123Aplasia of the phalanges of the hand (HP:0009802)1.70706558
124Broad metatarsal (HP:0001783)1.70701242
125Abnormality of oral frenula (HP:0000190)1.70151202
126Arnold-Chiari malformation (HP:0002308)1.69580227
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.69568092
12811 pairs of ribs (HP:0000878)1.69033512
129Acanthocytosis (HP:0001927)1.68769910
130Rhabdomyosarcoma (HP:0002859)1.68756818
131Aortic dissection (HP:0002647)1.68505795
132Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67812087
133Heterotopia (HP:0002282)1.67808140
134Deviation of the thumb (HP:0009603)1.66924810
135Aneurysm (HP:0002617)1.66045099
136Abnormality of complement system (HP:0005339)1.65688058
137Coronal craniosynostosis (HP:0004440)1.65528364
138Arterial tortuosity (HP:0005116)1.65018829
139Omphalocele (HP:0001539)1.63965274
140Abnormality of fatty-acid metabolism (HP:0004359)1.61662100
141Broad palm (HP:0001169)1.61125281
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60983423
143Bone cyst (HP:0012062)1.60978291
144Broad nasal tip (HP:0000455)1.60276760
145Dilatation of the ascending aorta (HP:0005111)1.59573107
146Glucose intolerance (HP:0000833)1.58991861
147Neoplasm of the thyroid gland (HP:0100031)1.58783906
148Neoplasm of the small intestine (HP:0100833)1.58175368
149Chromsome breakage (HP:0040012)1.58019082
150Abnormality of serum amino acid levels (HP:0003112)1.57739126
151Aqueductal stenosis (HP:0002410)1.57327526
152Hyperuricemia (HP:0002149)1.57244759
153Increased purine levels (HP:0004368)1.57244759
154Spastic diplegia (HP:0001264)1.57108286
155Abnormality of the gastric mucosa (HP:0004295)1.56888045
156Absent eyebrow (HP:0002223)1.56843400
157Excessive salivation (HP:0003781)1.56472725
158Protrusio acetabuli (HP:0003179)1.56361144
159Uterine neoplasm (HP:0010784)1.55938573
160Short chin (HP:0000331)1.55807065
161Thickened helices (HP:0000391)1.55488534
162Male infertility (HP:0003251)1.55409505
163Advanced eruption of teeth (HP:0006288)1.55201678
164Hypoplastic ischia (HP:0003175)1.54823255
165Mildly elevated creatine phosphokinase (HP:0008180)1.54076227
166Pulmonic stenosis (HP:0001642)1.54063142
167Protuberant abdomen (HP:0001538)1.53355260
168Genu recurvatum (HP:0002816)1.52776588
169Hypobetalipoproteinemia (HP:0003563)1.51682688
170Myelomeningocele (HP:0002475)1.51396041
171Thoracolumbar scoliosis (HP:0002944)1.51214269
172Renal cell carcinoma (HP:0005584)1.50724819
173Insomnia (HP:0100785)1.50643088
174Aortic aneurysm (HP:0004942)1.50508115
175Limited elbow extension (HP:0001377)1.50499402
176Abnormality of the 4th metacarpal (HP:0010012)1.50478136
177Polar cataract (HP:0010696)1.50311943
178Relative macrocephaly (HP:0004482)1.50220815
179Abnormal glucose tolerance (HP:0001952)1.49575175
180Partial agenesis of the corpus callosum (HP:0001338)1.49361948
181Abnormality of the fingertips (HP:0001211)1.49351906
182Tetraplegia (HP:0002445)1.49216646
183Hypopigmentation of the fundus (HP:0007894)1.48886335
184Scanning speech (HP:0002168)1.48019513
185Proximal placement of thumb (HP:0009623)1.47519637
186Abnormality of nail color (HP:0100643)1.47370773
187Biliary tract neoplasm (HP:0100574)1.47338620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.43411517
2TRIB34.43265569
3FRK4.42797226
4LATS14.06646070
5MAP3K103.58206284
6SIK13.40653157
7CAMK1G3.26555286
8CASK2.87977451
9FGFR22.85602606
10BRD42.57514131
11MKNK22.56435807
12LMTK22.08394588
13RIPK11.89274103
14STK31.87399183
15MKNK11.80752153
16PDGFRA1.79261046
17MST1R1.78743231
18INSRR1.73206788
19FGFR31.72495693
20PKN21.72013341
21LATS21.60928222
22PNCK1.56719735
23MAP3K21.48617153
24DDR21.45750770
25TTK1.45303723
26CDK61.43806521
27MET1.43621530
28SRPK11.42005727
29PDK31.38795932
30PDK41.38795932
31SCYL21.38647370
32KSR21.37518576
33CDK91.34504308
34PRKAA21.33787512
35EPHB21.32432910
36PDGFRB1.25820315
37CDC71.24833632
38YES11.24160551
39BCR1.23349691
40PRKAA11.22470429
41TSSK61.21651133
42NUAK11.21384739
43PTK61.21069568
44SGK21.19448473
45MAP3K41.17713214
46RET1.16867549
47BCKDK1.08771238
48TYRO31.06558666
49ERBB31.05078375
50STK241.05070734
51MTOR1.01950969
52PIK3CA0.99674758
53PAK60.99180857
54RPS6KB20.98243628
55MAP2K10.94353805
56FGFR10.91885779
57MELK0.91551791
58TAOK30.89490172
59TAF10.88846810
60PBK0.88838056
61BRSK20.88727063
62MAP3K60.88569374
63PAK30.86974373
64PDPK10.85759152
65ERBB40.85670332
66CSNK1G10.85334257
67PRPF4B0.84249912
68FGFR40.83031479
69PRKD30.82671558
70NEK10.81741266
71GSK3A0.79941213
72PLK40.76688254
73MAP2K40.75662957
74STK390.75188691
75KSR10.74092190
76NEK90.72688728
77PDK20.72257945
78WEE10.70709996
79MARK10.69152667
80CSNK1A1L0.68842258
81BMX0.68675646
82EPHA30.68577850
83CSNK1G20.66884078
84EIF2AK30.66626307
85PAK20.65653470
86CDK120.64972730
87STK38L0.63863651
88EIF2AK10.63742205
89NEK20.63482075
90PDK10.63381780
91ATM0.62562967
92PTK20.61052348
93CHEK20.60216353
94CDK40.59485122
95STK110.59104647
96JAK10.58684449
97NTRK10.58041131
98MAPK110.57615970
99JAK20.56694326
100NEK60.56315343
101MAP3K90.55898540
102CHEK10.55653846
103ACVR1B0.55437698
104ICK0.55046473
105IGF1R0.54518008
106TNIK0.53973203
107CAMKK20.52247191
108TTN0.51553453
109SGK30.51356260
110FER0.50923030
111PRKCH0.50419889
112CSNK1E0.50355966
113NTRK20.48603926
114SMG10.48360284
115CDK10.47851566
116NTRK30.47668036
117MAP2K70.45132091
118EPHB10.44490086
119RPS6KB10.43866187
120CLK10.43138433
121CDK70.42921622
122RPS6KA40.42713938
123RAF10.42333777
124DMPK0.42312257
125BRAF0.42084957
126DYRK20.41674728
127CDK20.41341655
128ATR0.40388511
129AKT30.39921973
130PRKD10.39552697
131MARK20.38713355
132EEF2K0.38446638
133DYRK1B0.38429068
134EPHA40.38248153
135PRKACG0.37630867
136CSNK1G30.37532947
137WNK30.36420542
138INSR0.35686833
139ERN10.35049569
140ALK0.34656470
141TAOK10.34253220
142WNK10.33263039
143MAP3K30.32272766
144MAPK100.32043310
145ERBB20.31759428
146PRKCZ0.30989054
147SGK4940.30581989
148SGK2230.30581989

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.64879082
2PPAR signaling pathway_Homo sapiens_hsa033203.26056513
3Nitrogen metabolism_Homo sapiens_hsa009103.05695301
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.85963991
5Vitamin B6 metabolism_Homo sapiens_hsa007502.82943360
6Propanoate metabolism_Homo sapiens_hsa006402.76053917
7Fatty acid metabolism_Homo sapiens_hsa012122.65784105
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55115034
9Fatty acid degradation_Homo sapiens_hsa000712.22814173
10Fat digestion and absorption_Homo sapiens_hsa049752.10352443
11Glycerolipid metabolism_Homo sapiens_hsa005612.06126282
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06045468
13Butanoate metabolism_Homo sapiens_hsa006502.04725873
14AMPK signaling pathway_Homo sapiens_hsa041521.77599280
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75658188
16Colorectal cancer_Homo sapiens_hsa052101.68871113
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.66788597
18ErbB signaling pathway_Homo sapiens_hsa040121.66226282
19Caffeine metabolism_Homo sapiens_hsa002321.65359102
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47252322
21Cell cycle_Homo sapiens_hsa041101.44354464
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43749733
23Sulfur metabolism_Homo sapiens_hsa009201.43326446
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.38245439
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36777936
26Insulin resistance_Homo sapiens_hsa049311.33259291
27Steroid biosynthesis_Homo sapiens_hsa001001.32998936
28beta-Alanine metabolism_Homo sapiens_hsa004101.32605407
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31997435
30Arginine biosynthesis_Homo sapiens_hsa002201.29579833
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28492495
32mRNA surveillance pathway_Homo sapiens_hsa030151.27018769
33Inositol phosphate metabolism_Homo sapiens_hsa005621.24128556
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22332441
35Tryptophan metabolism_Homo sapiens_hsa003801.21860970
36mTOR signaling pathway_Homo sapiens_hsa041501.18131819
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16433977
38Pyruvate metabolism_Homo sapiens_hsa006201.16406601
39Type II diabetes mellitus_Homo sapiens_hsa049301.13687294
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11471448
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09116044
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08223687
43Insulin signaling pathway_Homo sapiens_hsa049101.07792545
44Peroxisome_Homo sapiens_hsa041461.06947792
45Long-term potentiation_Homo sapiens_hsa047201.06386840
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.05607807
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05186062
48Glycerophospholipid metabolism_Homo sapiens_hsa005641.04122074
49Non-homologous end-joining_Homo sapiens_hsa034501.04044344
50Alcoholism_Homo sapiens_hsa050341.03475621
51Axon guidance_Homo sapiens_hsa043601.02322110
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02254683
53Carbon metabolism_Homo sapiens_hsa012000.99650680
54Bile secretion_Homo sapiens_hsa049760.95975329
55Gap junction_Homo sapiens_hsa045400.92932240
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92876291
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92824028
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90143744
59Lysine degradation_Homo sapiens_hsa003100.88967164
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88903401
61ECM-receptor interaction_Homo sapiens_hsa045120.83980478
62VEGF signaling pathway_Homo sapiens_hsa043700.82995193
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.82651225
64Wnt signaling pathway_Homo sapiens_hsa043100.82197336
65Bladder cancer_Homo sapiens_hsa052190.81112371
66Acute myeloid leukemia_Homo sapiens_hsa052210.79786055
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79631333
68Starch and sucrose metabolism_Homo sapiens_hsa005000.78075449
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.77492722
70Glucagon signaling pathway_Homo sapiens_hsa049220.75414289
71Endometrial cancer_Homo sapiens_hsa052130.75365341
72Protein digestion and absorption_Homo sapiens_hsa049740.75280866
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75104602
74Renal cell carcinoma_Homo sapiens_hsa052110.72606811
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.72248082
76Phenylalanine metabolism_Homo sapiens_hsa003600.72052055
77Basal cell carcinoma_Homo sapiens_hsa052170.71866305
78Complement and coagulation cascades_Homo sapiens_hsa046100.71793771
79Fatty acid elongation_Homo sapiens_hsa000620.70848218
80Vitamin digestion and absorption_Homo sapiens_hsa049770.70719225
81Viral carcinogenesis_Homo sapiens_hsa052030.70557100
82GnRH signaling pathway_Homo sapiens_hsa049120.69773168
83Pathways in cancer_Homo sapiens_hsa052000.69756553
84Focal adhesion_Homo sapiens_hsa045100.69721818
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69280692
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68118490
87RNA transport_Homo sapiens_hsa030130.66892063
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66184580
89Small cell lung cancer_Homo sapiens_hsa052220.65641867
90Tyrosine metabolism_Homo sapiens_hsa003500.64625592
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64445431
92Hedgehog signaling pathway_Homo sapiens_hsa043400.64226078
93ABC transporters_Homo sapiens_hsa020100.64033958
94Melanogenesis_Homo sapiens_hsa049160.63970616
95Prostate cancer_Homo sapiens_hsa052150.62611028
96Pentose phosphate pathway_Homo sapiens_hsa000300.62445209
97Adherens junction_Homo sapiens_hsa045200.62186668
98Mineral absorption_Homo sapiens_hsa049780.61740056
99Long-term depression_Homo sapiens_hsa047300.60215299
100Oocyte meiosis_Homo sapiens_hsa041140.59518179
101Glioma_Homo sapiens_hsa052140.59413778
102Prion diseases_Homo sapiens_hsa050200.58663979
103FoxO signaling pathway_Homo sapiens_hsa040680.58383906
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57602928
105Systemic lupus erythematosus_Homo sapiens_hsa053220.57597391
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57385799
107Renin-angiotensin system_Homo sapiens_hsa046140.57342451
108Proteoglycans in cancer_Homo sapiens_hsa052050.56494413
109Selenocompound metabolism_Homo sapiens_hsa004500.54414744
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.53593361
111Chronic myeloid leukemia_Homo sapiens_hsa052200.53446500
112Dorso-ventral axis formation_Homo sapiens_hsa043200.52823389
113Rap1 signaling pathway_Homo sapiens_hsa040150.52131225
114Cholinergic synapse_Homo sapiens_hsa047250.50439492
115Pancreatic cancer_Homo sapiens_hsa052120.49620292
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48908917
117Tight junction_Homo sapiens_hsa045300.48033848
118Biosynthesis of amino acids_Homo sapiens_hsa012300.47404949
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46250503
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45952619
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45324758
122MicroRNAs in cancer_Homo sapiens_hsa052060.45183897
123Staphylococcus aureus infection_Homo sapiens_hsa051500.44006605
124TGF-beta signaling pathway_Homo sapiens_hsa043500.43314560
125Choline metabolism in cancer_Homo sapiens_hsa052310.40819469
126Thyroid cancer_Homo sapiens_hsa052160.40607471
127Melanoma_Homo sapiens_hsa052180.38940196
128Amoebiasis_Homo sapiens_hsa051460.38751312
129Prolactin signaling pathway_Homo sapiens_hsa049170.36731730
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.36175670
131Hippo signaling pathway_Homo sapiens_hsa043900.35920108
132Non-small cell lung cancer_Homo sapiens_hsa052230.34507226
133Ovarian steroidogenesis_Homo sapiens_hsa049130.34142106
134Thyroid hormone synthesis_Homo sapiens_hsa049180.34132528
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.33613048
136Histidine metabolism_Homo sapiens_hsa003400.32853035
137Estrogen signaling pathway_Homo sapiens_hsa049150.31443235
138Retinol metabolism_Homo sapiens_hsa008300.29460176
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29072174
140Renin secretion_Homo sapiens_hsa049240.28241358
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27866338

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