PAGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: C16ORF53 (PA1) is a component of a Set1-like multiprotein histone methyltransferase complex (Cho et al., 2007 [PubMed 17500065]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)5.47577030
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.74921559
3viral transcription (GO:0019083)4.74500909
4ribosomal small subunit assembly (GO:0000028)4.54379063
5translational termination (GO:0006415)4.48004684
6chaperone-mediated protein transport (GO:0072321)4.41194020
7maturation of SSU-rRNA (GO:0030490)4.38239151
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.32269748
9regulation of mitochondrial translation (GO:0070129)4.13789830
10translational elongation (GO:0006414)4.00419084
11heterochromatin organization (GO:0070828)3.81925657
12pyrimidine nucleotide catabolic process (GO:0006244)3.81394181
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.80804430
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.80279110
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77970993
16cotranslational protein targeting to membrane (GO:0006613)3.74795180
17protein targeting to ER (GO:0045047)3.70992282
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.69449754
19DNA strand elongation involved in DNA replication (GO:0006271)3.66281089
20viral life cycle (GO:0019058)3.65539104
21cellular protein complex disassembly (GO:0043624)3.57403572
22peptidyl-arginine omega-N-methylation (GO:0035247)3.56847555
23ATP synthesis coupled proton transport (GO:0015986)3.56739884
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56739884
25DNA strand elongation (GO:0022616)3.55252605
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53570085
27L-serine metabolic process (GO:0006563)3.53430850
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48401917
29histone arginine methylation (GO:0034969)3.48391789
30protein localization to endoplasmic reticulum (GO:0070972)3.46066519
31pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.44789419
32ribonucleoprotein complex biogenesis (GO:0022613)3.44288257
33protein complex disassembly (GO:0043241)3.41223158
34chromatin remodeling at centromere (GO:0031055)3.36347853
35translational initiation (GO:0006413)3.33400473
36DNA unwinding involved in DNA replication (GO:0006268)3.33163036
37ribosomal large subunit biogenesis (GO:0042273)3.31439171
38telomere maintenance via semi-conservative replication (GO:0032201)3.30592654
39iron-sulfur cluster assembly (GO:0016226)3.25416614
40metallo-sulfur cluster assembly (GO:0031163)3.25416614
41macromolecular complex disassembly (GO:0032984)3.24390044
42pseudouridine synthesis (GO:0001522)3.22831905
43DNA damage response, detection of DNA damage (GO:0042769)3.21228192
44DNA replication checkpoint (GO:0000076)3.18159712
45establishment of mitochondrion localization (GO:0051654)3.18153098
46negative regulation of mRNA processing (GO:0050686)3.17744596
47cellular component biogenesis (GO:0044085)3.17499660
48negative regulation of RNA splicing (GO:0033119)3.16715226
49pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.15111093
50pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.14762810
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14114769
52peptidyl-arginine N-methylation (GO:0035246)3.07579820
53peptidyl-arginine methylation (GO:0018216)3.07579820
54CENP-A containing nucleosome assembly (GO:0034080)3.06638496
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04787040
56mitochondrion transport along microtubule (GO:0047497)3.04787040
57establishment of protein localization to mitochondrion (GO:0072655)3.04008538
58protein targeting to mitochondrion (GO:0006626)3.01034352
59chromatin assembly (GO:0031497)3.00668484
60base-excision repair, AP site formation (GO:0006285)2.98243531
61translation (GO:0006412)2.98152187
62protein complex biogenesis (GO:0070271)2.96109538
63respiratory electron transport chain (GO:0022904)2.95681003
64DNA replication-independent nucleosome assembly (GO:0006336)2.94748451
65DNA replication-independent nucleosome organization (GO:0034724)2.94748451
66mitochondrial respiratory chain complex assembly (GO:0033108)2.93620456
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.89594742
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.89594742
69NADH dehydrogenase complex assembly (GO:0010257)2.89594742
70negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88152963
71spliceosomal snRNP assembly (GO:0000387)2.87990642
72electron transport chain (GO:0022900)2.87551612
73ribosome biogenesis (GO:0042254)2.86566146
74negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83687255
75kinetochore assembly (GO:0051382)2.83337389
76establishment of integrated proviral latency (GO:0075713)2.81439732
77chromatin assembly or disassembly (GO:0006333)2.78261021
78protein localization to mitochondrion (GO:0070585)2.78213990
79termination of RNA polymerase III transcription (GO:0006386)2.75884155
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.75884155
81substrate-independent telencephalic tangential migration (GO:0021826)2.75047478
82substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.75047478
83inner mitochondrial membrane organization (GO:0007007)2.74918412
84rRNA processing (GO:0006364)2.74672840
85deoxyribonucleotide catabolic process (GO:0009264)2.74107225
86nuclear-transcribed mRNA catabolic process (GO:0000956)2.73990288
87pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.72570120
88CTP biosynthetic process (GO:0006241)2.71806935
89CTP metabolic process (GO:0046036)2.71806935
90formation of translation preinitiation complex (GO:0001731)2.68922108
91UTP biosynthetic process (GO:0006228)2.65016670
92guanosine-containing compound biosynthetic process (GO:1901070)2.64659302
93negative regulation of mRNA metabolic process (GO:1903312)2.64084762
94DNA replication initiation (GO:0006270)2.63717297
95GTP biosynthetic process (GO:0006183)2.63306037
96protein targeting to membrane (GO:0006612)2.62927022
97rRNA metabolic process (GO:0016072)2.61207416
98neurofilament cytoskeleton organization (GO:0060052)2.60877499
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.60462286
100mRNA catabolic process (GO:0006402)2.60255057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.23439850
2E2F7_22180533_ChIP-Seq_HELA_Human3.92385143
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.65873905
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.65029594
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17039643
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96880835
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72165766
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67239981
9XRN2_22483619_ChIP-Seq_HELA_Human2.63059460
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.57906001
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47556242
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33995629
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31091304
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30980472
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08851305
16GABP_19822575_ChIP-Seq_HepG2_Human2.03806530
17CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.03805462
18EST1_17652178_ChIP-ChIP_JURKAT_Human1.99353821
19YY1_21170310_ChIP-Seq_MESCs_Mouse1.95741526
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.95696101
21TTF2_22483619_ChIP-Seq_HELA_Human1.95047840
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94365676
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87682224
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87312607
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81774506
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.81651287
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78951324
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76845870
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75062237
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73676410
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69503183
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69469031
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69112772
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68485896
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68349090
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61951126
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61069348
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59506428
39DCP1A_22483619_ChIP-Seq_HELA_Human1.58599709
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55599036
41SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.55001019
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.54350137
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52752066
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51634406
45KDM5A_27292631_Chip-Seq_BREAST_Human1.50603264
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.50332323
47ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48386714
48FOXP3_21729870_ChIP-Seq_TREG_Human1.46913224
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43300192
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41834430
51FOXP1_21924763_ChIP-Seq_HESCs_Human1.38232563
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37160477
53VDR_21846776_ChIP-Seq_THP-1_Human1.37138059
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.36354261
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34317345
56CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31296271
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30703702
58P68_20966046_ChIP-Seq_HELA_Human1.30262355
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28790478
60LXR_22292898_ChIP-Seq_THP-1_Human1.28639565
61SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25764765
62MYC_22102868_ChIP-Seq_BL_Human1.25601706
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25589953
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25207367
65EZH2_22144423_ChIP-Seq_EOC_Human1.24966010
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23226118
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23054166
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22694668
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22071803
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20317625
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18196047
72* CIITA_25753668_ChIP-Seq_RAJI_Human1.17006595
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.16851550
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16101378
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14853970
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13207805
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.11566058
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11286774
79VDR_23849224_ChIP-Seq_CD4+_Human1.09722214
80ZNF263_19887448_ChIP-Seq_K562_Human1.09440874
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07169532
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06983748
83CTCF_27219007_Chip-Seq_Bcells_Human1.05531623
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04851291
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.02720705
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00457182
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.99164469
88SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98223859
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98007451
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96043256
91CTCF_26484167_Chip-Seq_Bcells_Mouse0.95864285
92PHF8_20622854_ChIP-Seq_HELA_Human0.94629171
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94124276
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93857491
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93289008
96MYC_18940864_ChIP-ChIP_HL60_Human0.93097033
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92702667
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92158654
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91095704
100EZH2_27304074_Chip-Seq_ESCs_Mouse0.90685770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.73154114
2MP0003123_paternal_imprinting3.29678398
3MP0003693_abnormal_embryo_hatching3.06644614
4MP0003111_abnormal_nucleus_morphology2.40190842
5MP0010094_abnormal_chromosome_stability2.28177101
6MP0009379_abnormal_foot_pigmentation2.24830277
7MP0005423_abnormal_somatic_nervous2.19339825
8MP0003787_abnormal_imprinting2.14900867
9MP0005499_abnormal_olfactory_system2.14195836
10MP0005394_taste/olfaction_phenotype2.14195836
11MP0008932_abnormal_embryonic_tissue2.13574383
12MP0001188_hyperpigmentation2.07741473
13MP0008789_abnormal_olfactory_epithelium2.04722229
14MP0002163_abnormal_gland_morphology2.04370756
15MP0002653_abnormal_ependyma_morphology2.03432321
16MP0002822_catalepsy1.98938649
17MP0008058_abnormal_DNA_repair1.97368611
18MP0003077_abnormal_cell_cycle1.95308231
19MP0003315_abnormal_perineum_morphology1.91930888
20MP0010030_abnormal_orbit_morphology1.91719018
21MP0004957_abnormal_blastocyst_morpholog1.86343422
22MP0000049_abnormal_middle_ear1.85362015
23MP0000537_abnormal_urethra_morphology1.83005702
24MP0000778_abnormal_nervous_system1.75402934
25MP0003880_abnormal_central_pattern1.74179265
26MP0003121_genomic_imprinting1.71253714
27MP0002249_abnormal_larynx_morphology1.70717722
28MP0002160_abnormal_reproductive_system1.62407807
29MP0001529_abnormal_vocalization1.59800113
30MP0004859_abnormal_synaptic_plasticity1.59618363
31MP0000566_synostosis1.52632517
32MP0001293_anophthalmia1.52107073
33MP0006276_abnormal_autonomic_nervous1.49228786
34MP0003122_maternal_imprinting1.48091179
35MP0004133_heterotaxia1.47000996
36MP0003942_abnormal_urinary_system1.43727321
37MP0004858_abnormal_nervous_system1.41956630
38MP0003861_abnormal_nervous_system1.38005944
39MP0003938_abnormal_ear_development1.36521427
40MP0000955_abnormal_spinal_cord1.34302803
41MP0002184_abnormal_innervation1.25657416
42MP0006035_abnormal_mitochondrial_morpho1.25229713
43MP0008995_early_reproductive_senescence1.24505855
44MP0004185_abnormal_adipocyte_glucose1.23050541
45MP0003136_yellow_coat_color1.20514231
46MP0003937_abnormal_limbs/digits/tail_de1.20430567
47MP0003786_premature_aging1.20035014
48MP0001346_abnormal_lacrimal_gland1.15915041
49MP0003119_abnormal_digestive_system1.13347262
50MP0001730_embryonic_growth_arrest1.12498403
51MP0004811_abnormal_neuron_physiology1.11964884
52MP0009672_abnormal_birth_weight1.11633731
53MP0002697_abnormal_eye_size1.11119315
54MP0002210_abnormal_sex_determination1.09252198
55MP0008877_abnormal_DNA_methylation1.08474790
56MP0002152_abnormal_brain_morphology1.06007943
57MP0002752_abnormal_somatic_nervous1.05441190
58MP0003890_abnormal_embryonic-extraembry1.04508494
59MP0003635_abnormal_synaptic_transmissio1.01963005
60MP0002085_abnormal_embryonic_tissue1.01273310
61MP0003567_abnormal_fetal_cardiomyocyte1.01210362
62MP0002882_abnormal_neuron_morphology0.99684432
63MP0002557_abnormal_social/conspecific_i0.98502877
64MP0000350_abnormal_cell_proliferation0.98464290
65MP0005377_hearing/vestibular/ear_phenot0.98370515
66MP0003878_abnormal_ear_physiology0.98370515
67MP0000678_abnormal_parathyroid_gland0.96996059
68MP0005187_abnormal_penis_morphology0.95631970
69MP0001286_abnormal_eye_development0.95308621
70MP0000631_abnormal_neuroendocrine_gland0.94155468
71MP0008007_abnormal_cellular_replicative0.93523912
72MP0002063_abnormal_learning/memory/cond0.92308380
73MP0002938_white_spotting0.92176692
74MP0005379_endocrine/exocrine_gland_phen0.91024610
75MP0001145_abnormal_male_reproductive0.88969371
76MP0002111_abnormal_tail_morphology0.87342521
77MP0002932_abnormal_joint_morphology0.87146484
78MP0001727_abnormal_embryo_implantation0.86428536
79MP0002084_abnormal_developmental_patter0.86129832
80MP0003385_abnormal_body_wall0.85789444
81MP0005646_abnormal_pituitary_gland0.85375067
82MP0002092_abnormal_eye_morphology0.85274739
83MP0006036_abnormal_mitochondrial_physio0.83891116
84MP0001984_abnormal_olfaction0.83396650
85MP0002734_abnormal_mechanical_nocicepti0.83066038
86MP0004145_abnormal_muscle_electrophysio0.82713650
87MP0002233_abnormal_nose_morphology0.82305407
88MP0005380_embryogenesis_phenotype0.81598383
89MP0001672_abnormal_embryogenesis/_devel0.81598383
90MP0001697_abnormal_embryo_size0.81037582
91MP0009053_abnormal_anal_canal0.79676719
92MP0002272_abnormal_nervous_system0.78015664
93MP0002736_abnormal_nociception_after0.77940675
94MP0009046_muscle_twitch0.77186841
95MP0002751_abnormal_autonomic_nervous0.76837363
96MP0000313_abnormal_cell_death0.76804818
97MP0002116_abnormal_craniofacial_bone0.75555423
98MP0002080_prenatal_lethality0.74472556
99MP0005389_reproductive_system_phenotype0.74253804
100MP0002572_abnormal_emotion/affect_behav0.74068766

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.51694471
2Myokymia (HP:0002411)3.60851220
3Abnormality of cells of the erythroid lineage (HP:0012130)3.40571228
4Broad distal phalanx of finger (HP:0009836)3.39880204
5Abnormal mitochondria in muscle tissue (HP:0008316)3.36372714
6Aplasia/Hypoplasia of the sacrum (HP:0008517)3.35970585
7Acute necrotizing encephalopathy (HP:0006965)3.35585874
8Abnormal number of erythroid precursors (HP:0012131)3.08646587
9Mitochondrial inheritance (HP:0001427)3.04685090
10Acute encephalopathy (HP:0006846)2.96554500
11Horseshoe kidney (HP:0000085)2.87677099
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.86948726
13Hepatocellular necrosis (HP:0001404)2.75596612
14Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75079302
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75079302
16Macrocytic anemia (HP:0001972)2.67985319
17Chromsome breakage (HP:0040012)2.63835278
18Increased CSF lactate (HP:0002490)2.58754615
19Increased intramyocellular lipid droplets (HP:0012240)2.55324686
20Rib fusion (HP:0000902)2.53413146
21Abnormal number of incisors (HP:0011064)2.49359767
22Increased hepatocellular lipid droplets (HP:0006565)2.45482402
23Hyperglycinemia (HP:0002154)2.44881033
24Microvesicular hepatic steatosis (HP:0001414)2.44173579
25Birth length less than 3rd percentile (HP:0003561)2.41628021
26Microretrognathia (HP:0000308)2.39217942
27Lipid accumulation in hepatocytes (HP:0006561)2.38563030
28Patellar aplasia (HP:0006443)2.34710156
29Aplasia/Hypoplasia of the patella (HP:0006498)2.31215755
30Cerebral edema (HP:0002181)2.30789934
31Hepatic necrosis (HP:0002605)2.30296505
32Progressive macrocephaly (HP:0004481)2.29087542
33Increased muscle lipid content (HP:0009058)2.28994977
34Duplication of thumb phalanx (HP:0009942)2.24835919
35Partial duplication of thumb phalanx (HP:0009944)2.24634294
36Optic nerve coloboma (HP:0000588)2.23243272
37Pallor (HP:0000980)2.21013264
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15453110
39Colon cancer (HP:0003003)2.12509917
40Increased serum pyruvate (HP:0003542)2.11562544
41Abnormality of the labia minora (HP:0012880)2.10658902
42Triphalangeal thumb (HP:0001199)2.09956787
43Cortical dysplasia (HP:0002539)2.08966045
44Renal Fanconi syndrome (HP:0001994)2.08356726
45Absent thumb (HP:0009777)2.07918907
46Testicular atrophy (HP:0000029)2.04754660
47Hepatoblastoma (HP:0002884)2.04283263
48Lactic acidosis (HP:0003128)2.03661771
49Partial duplication of the phalanx of hand (HP:0009999)2.01576978
50Abnormality of glycolysis (HP:0004366)2.00264897
51Overriding aorta (HP:0002623)1.99401397
52Abnormality of cochlea (HP:0000375)1.99023071
53Progressive microcephaly (HP:0000253)1.98639928
54Long foot (HP:0001833)1.98002078
55Exercise intolerance (HP:0003546)1.97623312
56Impulsivity (HP:0100710)1.97133882
57Absent radius (HP:0003974)1.96864626
58Increased serum lactate (HP:0002151)1.96494526
59Dysphonia (HP:0001618)1.95714216
60High anterior hairline (HP:0009890)1.93844217
61Meckel diverticulum (HP:0002245)1.92876741
62Neoplasm of the adrenal cortex (HP:0100641)1.92508045
63Poor suck (HP:0002033)1.92317652
64Calcaneovalgus deformity (HP:0001848)1.92259426
65Aplasia involving forearm bones (HP:0009822)1.87940050
66Absent forearm bone (HP:0003953)1.87940050
67Hyperthyroidism (HP:0000836)1.87500452
683-Methylglutaconic aciduria (HP:0003535)1.87498145
69Cerebral hypomyelination (HP:0006808)1.85293848
70Ectopic kidney (HP:0000086)1.83169347
71Cerebellar hypoplasia (HP:0001321)1.80460945
72Abnormality of the ileum (HP:0001549)1.80452653
73Ragged-red muscle fibers (HP:0003200)1.80168469
74Restlessness (HP:0000711)1.74967865
75Hyperacusis (HP:0010780)1.74808931
76Short thumb (HP:0009778)1.74273641
77Cleft eyelid (HP:0000625)1.73723015
78Deformed tarsal bones (HP:0008119)1.71667122
79Anomalous pulmonary venous return (HP:0010772)1.70623662
80Truncus arteriosus (HP:0001660)1.70329276
81Hypoplasia of the radius (HP:0002984)1.69526596
82Patent foramen ovale (HP:0001655)1.67598920
83Abnormality of the aortic arch (HP:0012303)1.67114363
84Pancytopenia (HP:0001876)1.67061049
85Respiratory difficulties (HP:0002880)1.67027420
86Leukodystrophy (HP:0002415)1.66379623
87Septate vagina (HP:0001153)1.66034953
88Breast hypoplasia (HP:0003187)1.65591616
89Multiple enchondromatosis (HP:0005701)1.65409045
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.65157352
91Atresia of the external auditory canal (HP:0000413)1.61564720
92Diastasis recti (HP:0001540)1.61051608
93Facial cleft (HP:0002006)1.59617504
94Abnormality of the lower motor neuron (HP:0002366)1.59088121
95Elfin facies (HP:0004428)1.58669260
96Morphological abnormality of the inner ear (HP:0011390)1.58307608
97Progressive muscle weakness (HP:0003323)1.57778985
98Concave nail (HP:0001598)1.57624936
99Partial agenesis of the corpus callosum (HP:0001338)1.57307896
100Septo-optic dysplasia (HP:0100842)1.57207383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.37019425
2CDC73.27161298
3VRK22.89376632
4STK162.86399646
5ZAK2.66992321
6BCKDK2.55481821
7BUB12.49556378
8DYRK22.27414186
9SRPK12.24789041
10KDR2.06981631
11TESK22.00232144
12DYRK31.93357715
13MAP2K71.86195478
14CASK1.79043174
15RPS6KA41.73976480
16AURKA1.73781761
17TTK1.64948452
18EEF2K1.62250860
19SMG11.61503555
20TRIB31.45480733
21PLK11.43259538
22BRSK11.40582500
23PLK41.38951288
24ARAF1.38516197
25MINK11.37141532
26ATR1.33789578
27NTRK21.30738966
28CHEK21.29588071
29WNK41.28625543
30CDK191.26227012
31MAP3K111.21510561
32MAP3K101.19655666
33NME11.15485637
34CSNK1G31.12658622
35NEK21.11251026
36NEK11.06747311
37LIMK11.06543415
38CSNK1G21.05444369
39CDK71.05050098
40VRK10.98199723
41SIK20.98027257
42AURKB0.97229227
43PIM20.96749103
44MAP2K40.95280519
45ABL20.92192078
46TESK10.91704620
47CDK11A0.91039760
48PRKCI0.90954162
49WEE10.88437260
50CDK140.87586980
51BRAF0.86815364
52DYRK1B0.86472932
53CDK150.86196610
54TAF10.84562791
55RPS6KA50.83927991
56TLK10.83872111
57CHEK10.82095750
58CDK180.79999814
59MAP4K20.79786201
60MARK10.78619420
61CAMKK10.77356392
62CAMK1D0.76647365
63PRKD30.75406703
64NTRK30.75019430
65TYRO30.73474106
66LRRK20.73102416
67CDK80.72796156
68AKT20.72389226
69MAP3K40.70601934
70CDK20.69723093
71PRKCG0.69337296
72CSNK1G10.69089181
73CSNK2A20.68948595
74PLK30.67918912
75CSNK1A1L0.66619717
76ILK0.65831810
77RPS6KA20.65246688
78PBK0.61920620
79CDK40.61910425
80CSNK2A10.61658133
81CDK10.61453864
82RPS6KB20.61442309
83IRAK30.59208453
84CSNK1E0.57283757
85MKNK10.55279059
86ALK0.54941075
87MAP3K80.53885505
88DAPK10.52602002
89STK40.50767321
90RPS6KA10.49380024
91EPHB20.48649965
92PRKDC0.47432224
93ICK0.47316388
94SCYL20.46471600
95ATM0.46225095
96MAP2K20.45703630
97UHMK10.44989269
98MAP3K90.42916231
99AKT10.42556412
100PKN20.39924703

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.60176728
2DNA replication_Homo sapiens_hsa030304.14502460
3Base excision repair_Homo sapiens_hsa034103.34982397
4Oxidative phosphorylation_Homo sapiens_hsa001903.23146811
5Sulfur relay system_Homo sapiens_hsa041223.19921081
6Parkinsons disease_Homo sapiens_hsa050123.02708049
7Mismatch repair_Homo sapiens_hsa034302.80551877
8Spliceosome_Homo sapiens_hsa030402.72223418
9RNA polymerase_Homo sapiens_hsa030202.43852933
10Proteasome_Homo sapiens_hsa030502.33527332
11Huntingtons disease_Homo sapiens_hsa050162.30675156
12Pyrimidine metabolism_Homo sapiens_hsa002402.08426709
13Homologous recombination_Homo sapiens_hsa034402.06838999
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.04098538
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89615213
16Fanconi anemia pathway_Homo sapiens_hsa034601.86516298
17Alzheimers disease_Homo sapiens_hsa050101.84803831
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81404276
19Cardiac muscle contraction_Homo sapiens_hsa042601.74621675
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74022728
21RNA transport_Homo sapiens_hsa030131.70300107
22Biosynthesis of amino acids_Homo sapiens_hsa012301.70140246
23Nucleotide excision repair_Homo sapiens_hsa034201.65928383
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61685601
25Cell cycle_Homo sapiens_hsa041101.55974149
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42854385
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41300266
28Vitamin B6 metabolism_Homo sapiens_hsa007501.36827467
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35586951
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.32614112
31mRNA surveillance pathway_Homo sapiens_hsa030151.32135831
32RNA degradation_Homo sapiens_hsa030181.28304292
33One carbon pool by folate_Homo sapiens_hsa006701.14070111
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13878044
35Folate biosynthesis_Homo sapiens_hsa007901.13008122
36Carbon metabolism_Homo sapiens_hsa012001.12690048
37Pyruvate metabolism_Homo sapiens_hsa006201.12534493
38Purine metabolism_Homo sapiens_hsa002301.09566267
39Protein export_Homo sapiens_hsa030601.09526353
40Non-homologous end-joining_Homo sapiens_hsa034501.07396290
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04598334
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04172890
43Fatty acid elongation_Homo sapiens_hsa000621.02695431
44Basal transcription factors_Homo sapiens_hsa030221.01965411
45Basal cell carcinoma_Homo sapiens_hsa052170.88933483
46Nicotine addiction_Homo sapiens_hsa050330.83158385
47Steroid biosynthesis_Homo sapiens_hsa001000.82970595
48Synaptic vesicle cycle_Homo sapiens_hsa047210.80564125
49Notch signaling pathway_Homo sapiens_hsa043300.75584113
50Pentose phosphate pathway_Homo sapiens_hsa000300.74706508
51Alcoholism_Homo sapiens_hsa050340.70426047
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69103766
53Metabolic pathways_Homo sapiens_hsa011000.67708558
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.67342193
55Arginine and proline metabolism_Homo sapiens_hsa003300.65086566
56Hedgehog signaling pathway_Homo sapiens_hsa043400.64817806
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63651912
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62812772
59Oocyte meiosis_Homo sapiens_hsa041140.61730123
60Hippo signaling pathway_Homo sapiens_hsa043900.59646417
61Axon guidance_Homo sapiens_hsa043600.59387750
62Galactose metabolism_Homo sapiens_hsa000520.58641830
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53343496
64Vibrio cholerae infection_Homo sapiens_hsa051100.48736345
65Wnt signaling pathway_Homo sapiens_hsa043100.48085594
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45695545
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44047880
68Phototransduction_Homo sapiens_hsa047440.42758303
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41617714
70Selenocompound metabolism_Homo sapiens_hsa004500.41135119
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40543296
72p53 signaling pathway_Homo sapiens_hsa041150.39227157
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38490460
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38261099
75Fatty acid metabolism_Homo sapiens_hsa012120.37809825
76Collecting duct acid secretion_Homo sapiens_hsa049660.37284861
77Fructose and mannose metabolism_Homo sapiens_hsa000510.36887989
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36773153
79Dopaminergic synapse_Homo sapiens_hsa047280.33954318
80Morphine addiction_Homo sapiens_hsa050320.33537096
81GABAergic synapse_Homo sapiens_hsa047270.33467008
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32016906
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31762260
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26744405
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.26358831
86Peroxisome_Homo sapiens_hsa041460.26226146
87N-Glycan biosynthesis_Homo sapiens_hsa005100.25909425
88Lysine degradation_Homo sapiens_hsa003100.24760492
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24430595
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22387086
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20135683
92Systemic lupus erythematosus_Homo sapiens_hsa053220.20132513
93Epstein-Barr virus infection_Homo sapiens_hsa051690.20076089
94Glutathione metabolism_Homo sapiens_hsa004800.17885218
95Phenylalanine metabolism_Homo sapiens_hsa003600.17867790
96Melanogenesis_Homo sapiens_hsa049160.15927187
97Bladder cancer_Homo sapiens_hsa052190.14711693
98AMPK signaling pathway_Homo sapiens_hsa041520.12668489
99Propanoate metabolism_Homo sapiens_hsa006400.11018177
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10982231

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