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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of family of proteins that are expressed in a variety of tumors and in some fetal and reproductive tissues. The encoded protein may protect cells from programmed cell death. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)6.82462879
2ribosome assembly (GO:0042255)6.50192808
3gas transport (GO:0015669)6.17207969
4ribosomal small subunit assembly (GO:0000028)5.66575793
5formation of translation preinitiation complex (GO:0001731)5.42950468
6regulation of translational fidelity (GO:0006450)4.88700975
7COPI coating of Golgi vesicle (GO:0048205)4.82615447
8Golgi transport vesicle coating (GO:0048200)4.82615447
9ribosomal small subunit biogenesis (GO:0042274)4.79673997
10viral transcription (GO:0019083)4.46127498
11translational termination (GO:0006415)4.34279735
12proteasome assembly (GO:0043248)4.26349564
13nuclear pore complex assembly (GO:0051292)4.25210501
14protoporphyrinogen IX biosynthetic process (GO:0006782)4.23287019
15protoporphyrinogen IX metabolic process (GO:0046501)4.15141291
16DNA unwinding involved in DNA replication (GO:0006268)4.10781011
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97579126
18translational initiation (GO:0006413)3.96464473
19ribosomal large subunit biogenesis (GO:0042273)3.95725937
20ATP synthesis coupled proton transport (GO:0015986)3.86079463
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86079463
22cotranslational protein targeting to membrane (GO:0006613)3.85331400
23protein targeting to ER (GO:0045047)3.82956035
24translational elongation (GO:0006414)3.80474188
25ribonucleoprotein complex biogenesis (GO:0022613)3.80460772
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73268994
27protein localization to endoplasmic reticulum (GO:0070972)3.72542673
28nuclear pore organization (GO:0006999)3.72411286
29synapsis (GO:0007129)3.71304842
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.68946012
31mitotic sister chromatid segregation (GO:0000070)3.62790461
32maturation of SSU-rRNA (GO:0030490)3.58769501
33cellular protein complex disassembly (GO:0043624)3.53836008
34viral life cycle (GO:0019058)3.52790150
35ribosome biogenesis (GO:0042254)3.49736075
36mitotic nuclear envelope disassembly (GO:0007077)3.46165305
37protein complex disassembly (GO:0043241)3.44288414
38positive regulation of vesicle fusion (GO:0031340)3.43482788
39nucleobase-containing small molecule interconversion (GO:0015949)3.41566694
40macromolecular complex disassembly (GO:0032984)3.38436187
41mitotic chromosome condensation (GO:0007076)3.35118241
42pore complex assembly (GO:0046931)3.34959330
43GMP metabolic process (GO:0046037)3.32983667
44tRNA aminoacylation for protein translation (GO:0006418)3.29505054
45proline biosynthetic process (GO:0006561)3.28897407
46sister chromatid segregation (GO:0000819)3.26890282
47mitotic metaphase plate congression (GO:0007080)3.26707600
48DNA strand elongation involved in DNA replication (GO:0006271)3.26123367
49translation (GO:0006412)3.25702818
50IMP biosynthetic process (GO:0006188)3.25546983
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.23439608
52protein targeting to mitochondrion (GO:0006626)3.23080079
53nucleoside diphosphate biosynthetic process (GO:0009133)3.21980955
54deoxyribose phosphate biosynthetic process (GO:0046385)3.21891345
552-deoxyribonucleotide biosynthetic process (GO:0009265)3.21891345
56DNA strand elongation (GO:0022616)3.18509307
57membrane disassembly (GO:0030397)3.17890586
58nuclear envelope disassembly (GO:0051081)3.17890586
59regulation of histone H3-K27 methylation (GO:0061085)3.17193815
60negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15773951
61tRNA aminoacylation (GO:0043039)3.15449387
62amino acid activation (GO:0043038)3.15449387
63protein maturation by protein folding (GO:0022417)3.14369063
64autophagic vacuole fusion (GO:0000046)3.11831729
65rRNA modification (GO:0000154)3.11420919
66regulation of mitotic spindle organization (GO:0060236)3.06902607
67oxidative phosphorylation (GO:0006119)3.04552048
68deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.03957117
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03710055
70regulation of translational elongation (GO:0006448)3.01861190
71establishment of protein localization to mitochondrion (GO:0072655)3.01639977
72regulation of RNA export from nucleus (GO:0046831)3.00964172
73telomere maintenance via semi-conservative replication (GO:0032201)3.00715940
74IMP metabolic process (GO:0046040)2.96572305
75protein-DNA complex disassembly (GO:0032986)2.95209191
76nucleosome disassembly (GO:0006337)2.95209191
77DNA replication initiation (GO:0006270)2.93565591
78DNA replication checkpoint (GO:0000076)2.93554600
79deoxyribonucleotide biosynthetic process (GO:0009263)2.92494807
80cellular component biogenesis (GO:0044085)2.91582808
81response to dietary excess (GO:0002021)2.88732475
82positive regulation of ligase activity (GO:0051351)2.88359228
83deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88127324
84homocysteine metabolic process (GO:0050667)2.86377318
85heme biosynthetic process (GO:0006783)2.82020761
86protein targeting to membrane (GO:0006612)2.80683250
87tetrahydrofolate metabolic process (GO:0046653)2.79187648
88regulation of ubiquitin-protein transferase activity (GO:0051438)2.77552216
89resolution of meiotic recombination intermediates (GO:0000712)2.74606807
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73443472
91folic acid-containing compound biosynthetic process (GO:0009396)2.73382748
92rRNA methylation (GO:0031167)2.73267671
93purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.72031938
94purine nucleoside monophosphate biosynthetic process (GO:0009127)2.72031938
95protein localization to mitochondrion (GO:0070585)2.71602175
96purine nucleobase biosynthetic process (GO:0009113)2.70727395
97diterpenoid biosynthetic process (GO:0016102)2.69384001
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.68115795
99protein localization to kinetochore (GO:0034501)2.67450877
100gonadal mesoderm development (GO:0007506)11.8573264

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.46557758
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11288980
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75865283
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.57154556
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.32134628
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12028726
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11448152
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.96088861
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85441073
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80175174
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.78955743
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69214458
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.65534358
14XRN2_22483619_ChIP-Seq_HELA_Human2.64676040
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58435836
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54638169
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54074824
18DCP1A_22483619_ChIP-Seq_HELA_Human2.52171746
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50234725
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48129630
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40041887
22ZNF263_19887448_ChIP-Seq_K562_Human2.31083416
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.30929387
24TTF2_22483619_ChIP-Seq_HELA_Human2.17914085
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10295629
26GABP_19822575_ChIP-Seq_HepG2_Human2.05644872
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96764683
28NCOR1_26117541_ChIP-Seq_K562_Human1.91698037
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91163811
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81567769
31VDR_23849224_ChIP-Seq_CD4+_Human1.80792268
32AR_21909140_ChIP-Seq_LNCAP_Human1.79354339
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.78467661
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77957238
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77421697
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.76880558
37ELK1_19687146_ChIP-ChIP_HELA_Human1.76707163
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76181174
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72845292
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71895439
41FOXP3_21729870_ChIP-Seq_TREG_Human1.66846002
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.65670746
43KDM5A_27292631_Chip-Seq_BREAST_Human1.63685452
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59788548
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57560177
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56830106
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56260922
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55302886
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54340137
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54105706
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52275373
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51723056
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49663437
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46945741
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44311020
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40586735
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36330939
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35962176
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35226169
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34084578
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31760310
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.31723601
63TFEB_21752829_ChIP-Seq_HELA_Human1.29035389
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27887358
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27373531
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25759078
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23999103
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23873500
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23213563
70E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23053401
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22619836
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21998336
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19160077
74MYC_22102868_ChIP-Seq_BL_Human1.15116052
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14470760
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13293424
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.12863969
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11983179
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11285208
80TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06289971
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06120379
82CIITA_25753668_ChIP-Seq_RAJI_Human1.06077481
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00395355
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98045014
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97931275
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97018557
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96414661
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96321891
89ATF3_27146783_Chip-Seq_COLON_Human0.96195591
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95089743
91VDR_21846776_ChIP-Seq_THP-1_Human0.94274097
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93631006
93CHD1_26751641_Chip-Seq_LNCaP_Human0.91694350
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91577400
95GATA1_19941826_ChIP-Seq_K562_Human0.90592578
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88032037
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87051471
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86718796
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86552965
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.86223792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence4.41895913
2MP0004147_increased_porphyrin_level3.83089765
3MP0004957_abnormal_blastocyst_morpholog3.75743612
4MP0003693_abnormal_embryo_hatching3.74136224
5MP0009697_abnormal_copulation3.58985624
6MP0003786_premature_aging3.56881480
7MP0008058_abnormal_DNA_repair3.48503395
8MP0003111_abnormal_nucleus_morphology3.30948252
9MP0005451_abnormal_body_composition3.23224744
10MP0003656_abnormal_erythrocyte_physiolo2.98226244
11MP0003077_abnormal_cell_cycle2.80745372
12MP0010094_abnormal_chromosome_stability2.75352035
13MP0008932_abnormal_embryonic_tissue2.64596263
14MP0000372_irregular_coat_pigmentation2.54088087
15MP0008007_abnormal_cellular_replicative2.41968013
16MP0002877_abnormal_melanocyte_morpholog2.30862033
17MP0004233_abnormal_muscle_weight2.18406374
18MP0005171_absent_coat_pigmentation2.18184366
19MP0005058_abnormal_lysosome_morphology2.16337006
20MP0006036_abnormal_mitochondrial_physio2.01547754
21MP0001661_extended_life_span2.01082189
22MP0000678_abnormal_parathyroid_gland2.00149134
23MP0000350_abnormal_cell_proliferation1.98857317
24MP0003806_abnormal_nucleotide_metabolis1.92684034
25MP0002132_abnormal_respiratory_system1.92045399
26MP0003186_abnormal_redox_activity1.89196247
27MP0001188_hyperpigmentation1.87513708
28MP0006035_abnormal_mitochondrial_morpho1.79343911
29MP0003136_yellow_coat_color1.76993106
30MP0000358_abnormal_cell_content/1.68555482
31MP0001730_embryonic_growth_arrest1.60544107
32MP0002210_abnormal_sex_determination1.60301187
33MP0005408_hypopigmentation1.58280472
34MP0000313_abnormal_cell_death1.54812296
35MP0001545_abnormal_hematopoietic_system1.51822217
36MP0005397_hematopoietic_system_phenotyp1.51822217
37MP0001697_abnormal_embryo_size1.50477643
38MP0003718_maternal_effect1.47555206
39MP0002080_prenatal_lethality1.45186068
40MP0001929_abnormal_gametogenesis1.44203904
41MP0008057_abnormal_DNA_replication1.33742354
42MP0005410_abnormal_fertilization1.30725431
43MP0003950_abnormal_plasma_membrane1.26063590
44MP0001672_abnormal_embryogenesis/_devel1.24989725
45MP0005380_embryogenesis_phenotype1.24989725
46MP0003984_embryonic_growth_retardation1.18299406
47MP0003698_abnormal_male_reproductive1.11592725
48MP0002269_muscular_atrophy1.10178357
49MP0002088_abnormal_embryonic_growth/wei1.10063932
50MP0001145_abnormal_male_reproductive1.08984096
51MP0003221_abnormal_cardiomyocyte_apopto1.06708061
52MP0002086_abnormal_extraembryonic_tissu1.04180214
53MP0000647_abnormal_sebaceous_gland1.03937591
54MP0010307_abnormal_tumor_latency1.01388569
55MP0000750_abnormal_muscle_regeneration1.00195547
56MP0000653_abnormal_sex_gland1.00150375
57MP0002019_abnormal_tumor_incidence0.99928590
58MP0004808_abnormal_hematopoietic_stem0.99733662
59MP0005083_abnormal_biliary_tract0.98145377
60MP0004885_abnormal_endolymph0.95896803
61MP0004272_abnormal_basement_membrane0.95403612
62MP0002163_abnormal_gland_morphology0.93981637
63MP0000858_altered_metastatic_potential0.93545045
64MP0000749_muscle_degeneration0.93349566
65MP0009840_abnormal_foam_cell0.91366540
66MP0009333_abnormal_splenocyte_physiolog0.88427389
67MP0010030_abnormal_orbit_morphology0.86046793
68MP0000681_abnormal_thyroid_gland0.83318304
69MP0002084_abnormal_developmental_patter0.82787420
70MP0002095_abnormal_skin_pigmentation0.81752614
71MP0000343_altered_response_to0.80770868
72MP0005330_cardiomyopathy0.79633540
73MP0002085_abnormal_embryonic_tissue0.78977279
74MP0003123_paternal_imprinting0.77803629
75MP0009278_abnormal_bone_marrow0.77165199
76MP0002161_abnormal_fertility/fecundity0.74598375
77MP0009672_abnormal_birth_weight0.74455560
78MP0005075_abnormal_melanosome_morpholog0.73347098
79MP0002396_abnormal_hematopoietic_system0.72973829
80MP0000703_abnormal_thymus_morphology0.71906274
81MP0008775_abnormal_heart_ventricle0.69830342
82MP0003959_abnormal_lean_body0.69474341
83MP0005220_abnormal_exocrine_pancreas0.69025665
84MP0005384_cellular_phenotype0.68699767
85MP0003385_abnormal_body_wall0.67814239
86MP0004043_abnormal_pH_regulation0.67730430
87MP0000759_abnormal_skeletal_muscle0.66134846
88MP0004145_abnormal_muscle_electrophysio0.65695619
89MP0005501_abnormal_skin_physiology0.65675654
90MP0001186_pigmentation_phenotype0.65141855
91MP0005636_abnormal_mineral_homeostasis0.62563861
92MP0001348_abnormal_lacrimal_gland0.62416267
93MP0003699_abnormal_female_reproductive0.61671936
94MP0001853_heart_inflammation0.61156146
95MP0001881_abnormal_mammary_gland0.60479263
96MP0001727_abnormal_embryo_implantation0.58251990
97MP0003567_abnormal_fetal_cardiomyocyte0.57650653
98MP0001529_abnormal_vocalization0.56059491
99MP0005621_abnormal_cell_physiology0.53977732
100MP0003942_abnormal_urinary_system0.52699115

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)6.53265461
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.41745274
3Cholecystitis (HP:0001082)5.19461753
4Abnormal gallbladder physiology (HP:0012438)5.19461753
5Reticulocytosis (HP:0001923)4.71092349
6Truncus arteriosus (HP:0001660)4.41186954
7Pallor (HP:0000980)4.12777181
8Ileus (HP:0002595)4.11665718
9Abnormality of reticulocytes (HP:0004312)4.08902726
10Hypertensive crisis (HP:0100735)3.98940231
11Upper limb muscle weakness (HP:0003484)3.73685909
12Hyperthyroidism (HP:0000836)3.73195520
13Abnormality of cells of the erythroid lineage (HP:0012130)3.57044401
14Ankyloglossia (HP:0010296)3.49628071
15Polycythemia (HP:0001901)3.47990187
16Neoplasm of head and neck (HP:0012288)3.43843000
17Esophageal neoplasm (HP:0100751)3.43843000
18Abnormal number of erythroid precursors (HP:0012131)3.24196915
19Cerebral hypomyelination (HP:0006808)3.10040918
20Acute encephalopathy (HP:0006846)3.00786936
21Submucous cleft hard palate (HP:0000176)2.90338918
22Seborrheic dermatitis (HP:0001051)2.80610666
23Reticulocytopenia (HP:0001896)2.77613523
24Breech presentation (HP:0001623)2.76233623
25Abnormality of the tricuspid valve (HP:0001702)2.66854214
26Abnormal mitochondria in muscle tissue (HP:0008316)2.64897299
27Spastic paraparesis (HP:0002313)2.64570766
28Acute necrotizing encephalopathy (HP:0006965)2.63828884
29Bowel incontinence (HP:0002607)2.62168389
30Abnormal large intestine physiology (HP:0012700)2.51220920
31Cholelithiasis (HP:0001081)2.50578478
32Abnormality of oral frenula (HP:0000190)2.48761664
33Hyperbilirubinemia (HP:0002904)2.48352045
34Abnormality of homocysteine metabolism (HP:0010919)2.43492570
35Homocystinuria (HP:0002156)2.43492570
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.40259275
37Type I transferrin isoform profile (HP:0003642)2.38910857
38Increased connective tissue (HP:0009025)2.38705628
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38164623
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38164623
41Male infertility (HP:0003251)2.34346291
42Macrocytic anemia (HP:0001972)2.33405123
43Relative macrocephaly (HP:0004482)2.32989937
44Birth length less than 3rd percentile (HP:0003561)2.32383664
45Lipid accumulation in hepatocytes (HP:0006561)2.29207467
46Diaphragmatic weakness (HP:0009113)2.29070622
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26686764
48Increased muscle lipid content (HP:0009058)2.26674175
49Increased intramyocellular lipid droplets (HP:0012240)2.26559545
50Abnormality of the gallbladder (HP:0005264)2.21471238
51Secondary amenorrhea (HP:0000869)2.19614339
52Insomnia (HP:0100785)2.19537257
53Poikilocytosis (HP:0004447)2.17038014
54Abnormal gallbladder morphology (HP:0012437)2.12817925
55Hypoparathyroidism (HP:0000829)2.12685867
56Palpitations (HP:0001962)2.12489086
57Abnormality of glycolysis (HP:0004366)2.12103994
58Shoulder girdle muscle weakness (HP:0003547)2.11079670
59Atelectasis (HP:0100750)2.09152438
60Long palpebral fissure (HP:0000637)2.08985963
61Fatigue (HP:0012378)2.08834304
62Respiratory difficulties (HP:0002880)2.04557720
63Renal Fanconi syndrome (HP:0001994)2.03942462
64CNS hypomyelination (HP:0003429)2.03304305
65Progressive macrocephaly (HP:0004481)2.02860541
66Increased hepatocellular lipid droplets (HP:0006565)2.00254837
67Hand muscle atrophy (HP:0009130)1.98421863
68Nausea (HP:0002018)1.97801817
69Myelodysplasia (HP:0002863)1.96597025
70Deep palmar crease (HP:0006191)1.96151715
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95886751
72Abnormal protein N-linked glycosylation (HP:0012347)1.95886751
73Abnormal protein glycosylation (HP:0012346)1.95886751
74Abnormal glycosylation (HP:0012345)1.95886751
75Chromosomal breakage induced by crosslinking agents (HP:0003221)1.95468653
76Rough bone trabeculation (HP:0100670)1.95460892
77Premature ovarian failure (HP:0008209)1.93861190
78Mitochondrial inheritance (HP:0001427)1.92794373
79Increased CSF lactate (HP:0002490)1.92014296
80Entropion (HP:0000621)1.91367282
81Tinnitus (HP:0000360)1.89019100
82Pelvic girdle muscle weakness (HP:0003749)1.87531251
83Deep philtrum (HP:0002002)1.87199581
84Ureteral duplication (HP:0000073)1.85627338
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85197053
86Centrally nucleated skeletal muscle fibers (HP:0003687)1.85082933
87Increased serum pyruvate (HP:0003542)1.84975048
88Overlapping toe (HP:0001845)1.83114868
89Hepatocellular necrosis (HP:0001404)1.82812157
90Chromsome breakage (HP:0040012)1.80937697
91Reduced antithrombin III activity (HP:0001976)1.80544814
92Small epiphyses (HP:0010585)1.79366626
93Abnormality of the intrinsic pathway (HP:0010989)1.78874884
94Exertional dyspnea (HP:0002875)1.77819650
95Vertebral compression fractures (HP:0002953)1.76314145
96Pheochromocytoma (HP:0002666)1.76247821
97Decreased subcutaneous fat (HP:0001002)1.75787874
98Abnormality of the preputium (HP:0100587)1.75681124
99Acanthocytosis (HP:0001927)1.75002770
100Cortical dysplasia (HP:0002539)1.73392340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.01290888
2NME24.21746032
3BRAF3.66574926
4IRAK33.58069653
5EIF2AK12.86023798
6BUB12.75807934
7NEK12.64834994
8KSR22.51382739
9TTK2.31725970
10PLK42.23820312
11ARAF2.20625718
12EIF2AK32.19730530
13SRPK12.06560970
14PBK1.99022838
15RAF11.83239440
16WEE11.74527036
17CLK11.72413870
18CCNB11.68695498
19EPHA21.64678351
20LMTK21.58487174
21BRSK11.54053321
22MOS1.50454935
23TAOK21.48515130
24RPS6KB21.45491807
25NME11.44546988
26PRPF4B1.44416186
27RIPK41.42174014
28EEF2K1.38596077
29KSR11.37370375
30TSSK61.36166276
31ILK1.35629538
32CDK121.35048811
33SCYL21.34792277
34NEK21.34512937
35BMX1.33024282
36BMPR21.27583561
37MAP3K21.26973002
38MAP3K81.23994906
39CDC71.20949907
40PAK41.16853010
41ICK1.16043901
42PAK11.10053441
43MET1.03252586
44TESK21.03191574
45STK161.00567763
46MST40.94871672
47MARK30.92969753
48CHEK20.89399575
49RPS6KA40.87846745
50VRK20.87377165
51STK40.87369393
52BRSK20.85063038
53MST1R0.83947770
54DYRK30.83606958
55PDK20.78594459
56STK100.77387548
57PINK10.76866325
58RPS6KA50.75880774
59FLT30.75726906
60AURKB0.75342818
61AURKA0.74763830
62IRAK40.67870066
63CHEK10.67324319
64EIF2AK20.65761507
65CDK80.65505603
66PIM20.61563427
67LRRK20.60593590
68NTRK30.59683625
69CDK70.58926008
70AKT20.58708694
71CSNK2A20.56977448
72PLK10.56542080
73PLK30.56393321
74ATM0.55013377
75IRAK20.53815590
76ATR0.50175766
77ERN10.48935234
78CDK11A0.48417164
79SIK30.47373099
80MAP3K130.47034060
81MAPKAPK30.46509821
82LATS20.43410504
83PAK20.42814045
84MAP3K90.42442156
85CDK150.41148840
86NTRK10.40678393
87ERBB40.40083650
88CDK140.40032246
89CDK180.39874978
90ALK0.39824979
91MAP3K10.39416606
92CDK10.39149598
93CSNK2A10.37139464
94CDK30.36844032
95CDK20.36838257
96STK30.36254159
97TRIB30.33377869
98PASK0.33279020
99PRKCI0.29955525
100MTOR0.29760842

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.29859962
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.41535579
3DNA replication_Homo sapiens_hsa030303.30628483
4Proteasome_Homo sapiens_hsa030503.03154737
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85002345
6Mismatch repair_Homo sapiens_hsa034302.83714271
7One carbon pool by folate_Homo sapiens_hsa006702.59891697
8RNA polymerase_Homo sapiens_hsa030202.37728999
9RNA transport_Homo sapiens_hsa030132.35421324
10Homologous recombination_Homo sapiens_hsa034402.18970889
11Nucleotide excision repair_Homo sapiens_hsa034202.15693153
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14077398
13Spliceosome_Homo sapiens_hsa030402.07003097
14Oxidative phosphorylation_Homo sapiens_hsa001902.05201384
15Parkinsons disease_Homo sapiens_hsa050122.04238809
16Sulfur relay system_Homo sapiens_hsa041221.81589556
17Biosynthesis of amino acids_Homo sapiens_hsa012301.80405604
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.78719522
19mRNA surveillance pathway_Homo sapiens_hsa030151.76302936
20Pyrimidine metabolism_Homo sapiens_hsa002401.72919789
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69909409
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.68865052
23Base excision repair_Homo sapiens_hsa034101.67066238
24Huntingtons disease_Homo sapiens_hsa050161.65281309
25Carbon metabolism_Homo sapiens_hsa012001.63200903
26Basal transcription factors_Homo sapiens_hsa030221.60557697
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59993740
28Cell cycle_Homo sapiens_hsa041101.57177064
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56561740
30Pyruvate metabolism_Homo sapiens_hsa006201.52377805
31N-Glycan biosynthesis_Homo sapiens_hsa005101.43381334
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39688422
33Pentose phosphate pathway_Homo sapiens_hsa000301.33662900
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28167670
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25871373
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24847040
37Fatty acid elongation_Homo sapiens_hsa000621.24420627
38Alzheimers disease_Homo sapiens_hsa050101.23675885
39Protein export_Homo sapiens_hsa030601.22848480
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20080123
41Fanconi anemia pathway_Homo sapiens_hsa034601.17928248
42Thyroid cancer_Homo sapiens_hsa052161.17107051
43Purine metabolism_Homo sapiens_hsa002301.15103994
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.11650132
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09421933
46Acute myeloid leukemia_Homo sapiens_hsa052211.07335209
47Fructose and mannose metabolism_Homo sapiens_hsa000511.01977776
48RNA degradation_Homo sapiens_hsa030181.00473544
49Chronic myeloid leukemia_Homo sapiens_hsa052201.00211442
50Non-small cell lung cancer_Homo sapiens_hsa052230.92633767
51Other glycan degradation_Homo sapiens_hsa005110.91937749
52Bladder cancer_Homo sapiens_hsa052190.86275717
53Folate biosynthesis_Homo sapiens_hsa007900.86258057
54Pancreatic cancer_Homo sapiens_hsa052120.83938918
55mTOR signaling pathway_Homo sapiens_hsa041500.83285408
56Non-homologous end-joining_Homo sapiens_hsa034500.80585113
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79227834
58Prion diseases_Homo sapiens_hsa050200.75530980
59Cardiac muscle contraction_Homo sapiens_hsa042600.71002482
60Olfactory transduction_Homo sapiens_hsa047400.68494621
61Renal cell carcinoma_Homo sapiens_hsa052110.67024692
62HIF-1 signaling pathway_Homo sapiens_hsa040660.65181271
63Arginine biosynthesis_Homo sapiens_hsa002200.61590244
64Oocyte meiosis_Homo sapiens_hsa041140.60186463
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59110197
66Insulin signaling pathway_Homo sapiens_hsa049100.59090156
67Glutathione metabolism_Homo sapiens_hsa004800.57976861
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.55366873
69Metabolic pathways_Homo sapiens_hsa011000.54672804
70Epstein-Barr virus infection_Homo sapiens_hsa051690.53490189
71Apoptosis_Homo sapiens_hsa042100.51511264
72ErbB signaling pathway_Homo sapiens_hsa040120.50960665
73Selenocompound metabolism_Homo sapiens_hsa004500.48042077
74Galactose metabolism_Homo sapiens_hsa000520.47175037
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45635345
76Viral carcinogenesis_Homo sapiens_hsa052030.45225308
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44780075
78Tyrosine metabolism_Homo sapiens_hsa003500.40711787
79Propanoate metabolism_Homo sapiens_hsa006400.39809192
80Glioma_Homo sapiens_hsa052140.37741974
81Endometrial cancer_Homo sapiens_hsa052130.37280641
82VEGF signaling pathway_Homo sapiens_hsa043700.36938649
83Colorectal cancer_Homo sapiens_hsa052100.36126893
84Circadian rhythm_Homo sapiens_hsa047100.34496845
85Steroid biosynthesis_Homo sapiens_hsa001000.33678320
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.33556213
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32377294
88Vibrio cholerae infection_Homo sapiens_hsa051100.31918146
89Phenylalanine metabolism_Homo sapiens_hsa003600.29399201
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26424263
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22719633
92Melanoma_Homo sapiens_hsa052180.21916671
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.19973600
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19908787
95p53 signaling pathway_Homo sapiens_hsa041150.18080291
96Hepatitis B_Homo sapiens_hsa051610.16908660
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15959082
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15088631
99Prostate cancer_Homo sapiens_hsa052150.14350674
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13214765

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