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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mesoderm development (GO:0007498)5.58223116
2mesenchyme development (GO:0060485)5.15134845
3nucleosome assembly (GO:0006334)4.42912240
4sex differentiation (GO:0007548)4.21753558
5gonadal mesoderm development (GO:0007506)39.2264027
6formation of translation preinitiation complex (GO:0001731)3.93772782
7ribosomal small subunit biogenesis (GO:0042274)3.85762245
8protein-DNA complex assembly (GO:0065004)3.83527666
9ribosomal small subunit assembly (GO:0000028)3.81409279
10nucleosome organization (GO:0034728)3.57409912
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41830150
12N-acetylneuraminate metabolic process (GO:0006054)3.25451378
13protein-DNA complex subunit organization (GO:0071824)3.18736568
14binding of sperm to zona pellucida (GO:0007339)3.18573348
15nucleobase-containing small molecule interconversion (GO:0015949)3.15078505
16ribosome assembly (GO:0042255)3.12826221
17rRNA modification (GO:0000154)3.10253979
18male meiosis (GO:0007140)3.09149926
19mitotic metaphase plate congression (GO:0007080)3.04724085
20deoxyribonucleotide biosynthetic process (GO:0009263)2.98876212
21COPI coating of Golgi vesicle (GO:0048205)2.83066371
22Golgi transport vesicle coating (GO:0048200)2.83066371
23mitochondrial fusion (GO:0008053)2.74269690
24urea metabolic process (GO:0019627)2.73583058
25activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.71829714
26nitrogen cycle metabolic process (GO:0071941)2.69014266
27ribonucleoprotein complex biogenesis (GO:0022613)2.67775606
28glyoxylate metabolic process (GO:0046487)2.67659572
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67272290
30rRNA methylation (GO:0031167)2.64119572
31phenylpropanoid metabolic process (GO:0009698)2.64102995
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64015226
33urea cycle (GO:0000050)2.63020832
34proteasome assembly (GO:0043248)2.62915286
35protein localization to endoplasmic reticulum (GO:0070972)2.62293960
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.61909370
37L-phenylalanine metabolic process (GO:0006558)2.61909370
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61798697
39synapsis (GO:0007129)2.61658113
40de novo posttranslational protein folding (GO:0051084)2.61458738
41amino acid salvage (GO:0043102)2.60777068
42L-methionine salvage (GO:0071267)2.60777068
43L-methionine biosynthetic process (GO:0071265)2.60777068
44viral transcription (GO:0019083)2.59630576
45cotranslational protein targeting to membrane (GO:0006613)2.59623017
46mitotic chromosome condensation (GO:0007076)2.58083878
47protein targeting to ER (GO:0045047)2.58040275
48regulation of oxidative stress-induced neuron death (GO:1903203)2.56594243
49regulation of bile acid biosynthetic process (GO:0070857)2.55993848
50proline metabolic process (GO:0006560)2.55523676
51translational termination (GO:0006415)2.54318423
52glycine metabolic process (GO:0006544)2.54242731
53mitochondrial DNA metabolic process (GO:0032042)2.53704566
54chromosome organization involved in meiosis (GO:0070192)2.53535453
55piRNA metabolic process (GO:0034587)2.51761038
56deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.50930692
57apoptotic cell clearance (GO:0043277)2.49686063
58positive regulation of ligase activity (GO:0051351)2.49295993
59translational initiation (GO:0006413)2.48100897
60establishment of protein localization to endoplasmic reticulum (GO:0072599)2.47859392
61de novo protein folding (GO:0006458)2.47529951
62regulation of protein activation cascade (GO:2000257)2.46831275
63ribosome biogenesis (GO:0042254)2.46425218
64metaphase plate congression (GO:0051310)2.44924852
65regulation of translational fidelity (GO:0006450)2.44554698
66myeloid cell homeostasis (GO:0002262)2.44210553
67translational elongation (GO:0006414)2.43108253
68drug metabolic process (GO:0017144)2.43036745
69cofactor catabolic process (GO:0051187)2.39983184
70bile acid biosynthetic process (GO:0006699)2.39867531
71alkaloid metabolic process (GO:0009820)2.39786776
72fusion of sperm to egg plasma membrane (GO:0007342)2.39141314
73meiotic nuclear division (GO:0007126)2.38711444
74protein carboxylation (GO:0018214)2.38425082
75peptidyl-glutamic acid carboxylation (GO:0017187)2.38425082
76sperm-egg recognition (GO:0035036)2.38292394
77male meiosis I (GO:0007141)2.38159404
78proline biosynthetic process (GO:0006561)2.37489788
79mitochondrial DNA replication (GO:0006264)2.35043641
80ribosomal large subunit biogenesis (GO:0042273)2.34899440
81translation (GO:0006412)2.34058535
82regulation of cellular amino acid metabolic process (GO:0006521)2.34023883
83mitotic sister chromatid segregation (GO:0000070)2.33301074
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.31837962
85glutamine family amino acid biosynthetic process (GO:0009084)2.30866174
86regulation of ubiquitin-protein transferase activity (GO:0051438)2.30662120
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.29447757
88oxidative demethylation (GO:0070989)2.29286087
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.26404313
90complement activation, classical pathway (GO:0006958)2.26145075
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.25908990
92organ or tissue specific immune response (GO:0002251)2.24186545
93tRNA aminoacylation for protein translation (GO:0006418)2.23182403
94synaptonemal complex assembly (GO:0007130)2.23045119
95meiosis I (GO:0007127)2.22500899
96L-phenylalanine catabolic process (GO:0006559)2.20424915
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.20424915
98regulation of ligase activity (GO:0051340)2.19702450
99sulfur amino acid catabolic process (GO:0000098)2.16033694
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.13664548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.36080224
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.92143900
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57412706
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.54853930
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.45696146
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40435470
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.35475476
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.14315535
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04053015
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.03389300
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92845007
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78431355
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.76859257
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52724627
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51864515
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.45969327
17DCP1A_22483619_ChIP-Seq_HELA_Human2.44800650
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33781812
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31541419
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.26741695
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26720127
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25414171
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13722489
24XRN2_22483619_ChIP-Seq_HELA_Human2.09881962
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07300072
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07289534
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07140960
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06608194
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05664109
30GABP_19822575_ChIP-Seq_HepG2_Human2.03210070
31TTF2_22483619_ChIP-Seq_HELA_Human1.94935519
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87869928
33AR_21909140_ChIP-Seq_LNCAP_Human1.87639260
34TFEB_21752829_ChIP-Seq_HELA_Human1.85039401
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84879161
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79841268
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78845380
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75008438
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73658416
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71999982
41VDR_23849224_ChIP-Seq_CD4+_Human1.66979463
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65200140
43CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.64945487
44ELK1_19687146_ChIP-ChIP_HELA_Human1.63897484
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62613129
46KDM5A_27292631_Chip-Seq_BREAST_Human1.59692747
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58738279
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57394649
49FOXP3_21729870_ChIP-Seq_TREG_Human1.54795904
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54766592
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.52648435
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.51984428
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43378212
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.43003222
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.42319337
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38069241
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.34883353
58ZNF263_19887448_ChIP-Seq_K562_Human1.33581053
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32803033
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31062796
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30237914
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29079656
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28952360
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.27202795
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24012569
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23138188
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23127751
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22981379
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22507083
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22109980
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20791805
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20470985
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18022515
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17480605
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16674724
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14214915
77TBX5_21415370_ChIP-Seq_HL-1_Mouse1.13487606
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12201245
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08994412
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08926174
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08451392
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05416749
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02678157
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01028452
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98773397
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97892435
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96626700
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96524017
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.96003224
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94690593
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93484936
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93152341
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91862833
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91104569
95GATA6_21074721_ChIP-Seq_CACO-2_Human0.87063614
96CIITA_25753668_ChIP-Seq_RAJI_Human0.84952039
97ATF3_27146783_Chip-Seq_COLON_Human0.83390404
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82152623
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80258037
100RBPJ_21746931_ChIP-Seq_IB4_Human0.79394768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation4.28909537
2MP0005360_urolithiasis4.19888647
3MP0003806_abnormal_nucleotide_metabolis4.16421736
4MP0003868_abnormal_feces_composition3.78035550
5MP0005058_abnormal_lysosome_morphology3.53942389
6MP0005085_abnormal_gallbladder_physiolo3.51794947
7MP0002138_abnormal_hepatobiliary_system3.45997309
8MP0002139_abnormal_hepatobiliary_system3.39842053
9MP0003693_abnormal_embryo_hatching2.79780948
10MP0005365_abnormal_bile_salt2.76204477
11MP0005171_absent_coat_pigmentation2.74063722
12MP0001661_extended_life_span2.68318086
13MP0009840_abnormal_foam_cell2.66949084
14MP0005408_hypopigmentation2.56052384
15MP0003252_abnormal_bile_duct2.53357735
16MP0005451_abnormal_body_composition2.39303366
17MP0004957_abnormal_blastocyst_morpholog2.36804411
18MP0003186_abnormal_redox_activity2.35104914
19MP0005410_abnormal_fertilization2.27288855
20MP0008875_abnormal_xenobiotic_pharmacok2.26884711
21MP0003136_yellow_coat_color2.23435559
22MP0003111_abnormal_nucleus_morphology2.16472611
23MP0003077_abnormal_cell_cycle2.16318458
24MP0003303_peritoneal_inflammation2.12555583
25MP0008058_abnormal_DNA_repair1.91799217
26MP0009333_abnormal_splenocyte_physiolog1.89884148
27MP0001666_abnormal_nutrient_absorption1.88465182
28MP0001764_abnormal_homeostasis1.87677631
29MP0006035_abnormal_mitochondrial_morpho1.76825296
30MP0003718_maternal_effect1.75767397
31MP0000358_abnormal_cell_content/1.73793082
32MP0001929_abnormal_gametogenesis1.60525044
33MP0010094_abnormal_chromosome_stability1.57791748
34MP0002210_abnormal_sex_determination1.57238027
35MP0006036_abnormal_mitochondrial_physio1.55373585
36MP0010386_abnormal_urinary_bladder1.54620196
37MP0008007_abnormal_cellular_replicative1.50804373
38MP0003698_abnormal_male_reproductive1.40245284
39MP0003786_premature_aging1.37225866
40MP0008932_abnormal_embryonic_tissue1.36866290
41MP0002090_abnormal_vision1.33721559
42MP0002160_abnormal_reproductive_system1.26853651
43MP0002132_abnormal_respiratory_system1.25955923
44MP0008260_abnormal_autophagy1.25332442
45MP0001145_abnormal_male_reproductive1.24836041
46MP0005395_other_phenotype1.22482513
47MP0000350_abnormal_cell_proliferation1.18063460
48MP0001730_embryonic_growth_arrest1.16860937
49MP0005332_abnormal_amino_acid1.12883013
50MP0002928_abnormal_bile_duct1.11415000
51MP0000609_abnormal_liver_physiology1.11075361
52MP0005389_reproductive_system_phenotype1.11043098
53MP0008995_early_reproductive_senescence1.07952679
54MP0000653_abnormal_sex_gland1.07214805
55MP0005319_abnormal_enzyme/_coenzyme1.00692133
56MP0000598_abnormal_liver_morphology1.00355648
57MP0001915_intracranial_hemorrhage0.97025129
58MP0002161_abnormal_fertility/fecundity0.96025003
59MP0010307_abnormal_tumor_latency0.95420991
60MP0003959_abnormal_lean_body0.93043080
61MP0001919_abnormal_reproductive_system0.91591031
62MP0002080_prenatal_lethality0.90804970
63MP0001697_abnormal_embryo_size0.89482495
64MP0003191_abnormal_cellular_cholesterol0.88048671
65MP0004019_abnormal_vitamin_homeostasis0.82685229
66MP0000313_abnormal_cell_death0.82345658
67MP0003195_calcinosis0.79994218
68MP0001529_abnormal_vocalization0.79965375
69MP0005384_cellular_phenotype0.79244104
70MP0005584_abnormal_enzyme/coenzyme_acti0.77619166
71MP0003950_abnormal_plasma_membrane0.76482522
72MP0002876_abnormal_thyroid_physiology0.75643669
73MP0000747_muscle_weakness0.74244323
74MP0009643_abnormal_urine_homeostasis0.72797688
75MP0009379_abnormal_foot_pigmentation0.71823702
76MP0002796_impaired_skin_barrier0.71380293
77MP0002089_abnormal_postnatal_growth/wei0.69408540
78MP0005501_abnormal_skin_physiology0.69303592
79MP0009672_abnormal_birth_weight0.68359354
80MP0005621_abnormal_cell_physiology0.67074474
81MP0004233_abnormal_muscle_weight0.65727948
82MP0010329_abnormal_lipoprotein_level0.63624530
83MP0002086_abnormal_extraembryonic_tissu0.62393185
84MP0000343_altered_response_to0.61552130
85MP0005174_abnormal_tail_pigmentation0.59481098
86MP0001348_abnormal_lacrimal_gland0.59024169
87MP0005636_abnormal_mineral_homeostasis0.58494041
88MP0005187_abnormal_penis_morphology0.57948871
89MP0005376_homeostasis/metabolism_phenot0.57145514
90MP0001186_pigmentation_phenotype0.55587653
91MP0003699_abnormal_female_reproductive0.53978792
92MP0003943_abnormal_hepatobiliary_system0.53773772
93MP0002084_abnormal_developmental_patter0.53454130
94MP0008004_abnormal_stomach_pH0.53389442
95MP0000490_abnormal_crypts_of0.52736555
96MP0005220_abnormal_exocrine_pancreas0.52120040
97MP0004808_abnormal_hematopoietic_stem0.51819163
98MP0002118_abnormal_lipid_homeostasis0.51751181
99MP0002269_muscular_atrophy0.51262402
100MP0010234_abnormal_vibrissa_follicle0.51175092

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)5.87888679
2Deep venous thrombosis (HP:0002625)4.46792741
3Vertebral compression fractures (HP:0002953)4.15139299
4Prolonged partial thromboplastin time (HP:0003645)3.90964726
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.80066553
6Spastic paraparesis (HP:0002313)3.74624183
7Hypobetalipoproteinemia (HP:0003563)3.67637265
8Vacuolated lymphocytes (HP:0001922)3.62147014
9Cerebral hypomyelination (HP:0006808)3.59595547
10Abnormal protein glycosylation (HP:0012346)3.58166545
11Abnormal glycosylation (HP:0012345)3.58166545
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.58166545
13Abnormal protein N-linked glycosylation (HP:0012347)3.58166545
14Abnormality of pyrimidine metabolism (HP:0004353)3.56633762
15Abnormality of the intrinsic pathway (HP:0010989)3.40007447
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37416474
17Type I transferrin isoform profile (HP:0003642)3.34743021
18Paraparesis (HP:0002385)3.28351760
19Hypokinesia (HP:0002375)3.22158338
20Patchy hypopigmentation of hair (HP:0011365)3.07199575
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.95537744
22Reticulocytopenia (HP:0001896)2.94949707
23Tetraparesis (HP:0002273)2.78040057
24Abnormal pupillary function (HP:0007686)2.73998222
25CNS hypomyelination (HP:0003429)2.70962014
26Cutaneous melanoma (HP:0012056)2.69109633
27Spinal cord lesions (HP:0100561)2.68000140
28Syringomyelia (HP:0003396)2.68000140
29Short nail (HP:0001799)2.67079503
30Abnormal tarsal ossification (HP:0008369)2.64443602
31Upper limb muscle weakness (HP:0003484)2.58884107
32Small epiphyses (HP:0010585)2.58749397
33Large for gestational age (HP:0001520)2.58440700
34Abnormality of methionine metabolism (HP:0010901)2.58400948
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48979765
36Generalized aminoaciduria (HP:0002909)2.48367206
37Lower limb hyperreflexia (HP:0002395)2.48177864
38Self-mutilation (HP:0000742)2.46087807
39Abnormality of the distal phalanges of the toes (HP:0010182)2.45117396
40Abnormality of liposaccharide metabolism (HP:0010968)2.44800005
41Abnormality of glycosphingolipid metabolism (HP:0004343)2.44800005
42Abnormality of glycolipid metabolism (HP:0010969)2.44800005
43Ependymoma (HP:0002888)2.42150603
44Mitral stenosis (HP:0001718)2.40902666
45Epiphyseal stippling (HP:0010655)2.40315719
46Progressive external ophthalmoplegia (HP:0000590)2.38304813
47Male infertility (HP:0003251)2.37897753
48Thoracic kyphosis (HP:0002942)2.34579006
49Carpal bone hypoplasia (HP:0001498)2.32259640
50Tinnitus (HP:0000360)2.30285426
51Hypoplasia of the uterus (HP:0000013)2.28654939
52Cholecystitis (HP:0001082)2.24710759
53Abnormal gallbladder physiology (HP:0012438)2.24710759
54Hyperammonemia (HP:0001987)2.23313486
55Entropion (HP:0000621)2.22932586
56Sparse eyelashes (HP:0000653)2.21873900
57White forelock (HP:0002211)2.18949077
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18415296
59Prolonged neonatal jaundice (HP:0006579)2.16040291
60Hypolipoproteinemia (HP:0010981)2.11433245
61Beaking of vertebral bodies (HP:0004568)2.10884968
62Flattened epiphyses (HP:0003071)2.09085605
63Abnormal foot bone ossification (HP:0010675)2.05758291
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.05516091
65Osteolytic defects of the hand bones (HP:0009699)2.05516091
66Proximal tubulopathy (HP:0000114)2.04585169
67Overlapping toe (HP:0001845)2.04455985
68Posterior subcapsular cataract (HP:0007787)2.04435192
69Elevated alkaline phosphatase (HP:0003155)2.04225166
70Abnormality of cells of the erythroid lineage (HP:0012130)2.03983329
71Abnormal spermatogenesis (HP:0008669)2.02386984
72Neoplasm of the peripheral nervous system (HP:0100007)2.00478595
73Acute encephalopathy (HP:0006846)1.99380224
74Albinism (HP:0001022)1.98265612
75Aplasia/hypoplasia of the uterus (HP:0008684)1.98047161
76Abnormality of the thoracic spine (HP:0100711)1.95770498
77Decreased subcutaneous fat (HP:0001002)1.94160777
78Abnormality of the preputium (HP:0100587)1.92672076
79Abnormality of the lumbar spine (HP:0100712)1.90986885
80Abnormality of fatty-acid metabolism (HP:0004359)1.90020093
81Abnormal number of erythroid precursors (HP:0012131)1.88052986
82Conjugated hyperbilirubinemia (HP:0002908)1.87483948
83Abnormal auditory evoked potentials (HP:0006958)1.87224610
84Opisthotonus (HP:0002179)1.85640516
85Intrahepatic cholestasis (HP:0001406)1.83244451
86Abnormality of alkaline phosphatase activity (HP:0004379)1.81679315
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81601285
88Hyperlipoproteinemia (HP:0010980)1.79031934
89Ureteral duplication (HP:0000073)1.78167931
90Cerebral edema (HP:0002181)1.77337449
91Abnormality of the Achilles tendon (HP:0005109)1.76581467
92Brushfield spots (HP:0001088)1.76217023
93Achilles tendon contracture (HP:0001771)1.75734049
94Acute necrotizing encephalopathy (HP:0006965)1.75083485
95Abnormal epiphyseal ossification (HP:0010656)1.74375751
96Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74216617
97Abnormality of subcutaneous fat tissue (HP:0001001)1.72549151
98Abnormal enzyme/coenzyme activity (HP:0012379)1.72387017
99Facial hemangioma (HP:0000329)1.72187610
100Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72001051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK34.80273297
2PBK4.76655469
3NME24.29106829
4PRPF4B3.99325608
5IRAK33.97619877
6NEK13.22348187
7ARAF2.54722745
8BUB12.53069977
9LMTK22.50308219
10TAOK22.43093574
11EIF2AK12.27713729
12SCYL22.10710031
13PAK61.99787911
14STK161.99631437
15MARK31.98482293
16MET1.93795165
17BRAF1.90491314
18PINK11.89005913
19ZAK1.84403373
20GRK71.62342139
21KSR21.57824362
22MAP3K91.57092898
23SRPK11.49253007
24CDK191.46772889
25IRAK21.41659076
26TESK21.38538350
27NEK21.38341832
28TLK11.38179761
29PAK41.25627775
30TSSK61.25086282
31MOS1.23241414
32BRSK11.21361064
33MST41.14662385
34EPHA21.10644395
35TTK1.00218274
36MST1R0.98749429
37PDK20.98160392
38CDK80.90893746
39WEE10.88282085
40PAK10.88059031
41BMX0.87348578
42PAK20.87031657
43RAF10.86378576
44IRAK40.84891346
45KSR10.84249618
46MAP3K80.83727712
47AKT20.82386985
48PRKCI0.81448174
49ERN10.79981316
50RPS6KA50.79318535
51PLK10.74796147
52ILK0.74502487
53STK100.72126083
54LRRK20.71633177
55AURKA0.71095984
56CDK30.70902556
57TESK10.63810554
58FLT30.60726227
59CCNB10.59274961
60MAP3K130.57949692
61PIM20.56664789
62STK40.54698166
63CLK10.52516297
64AURKB0.50522318
65ERBB40.50475296
66PLK40.48893566
67CHEK20.47740673
68CDK140.46168725
69MAP3K120.42589905
70PDPK10.42028154
71CDK11A0.41986097
72CDK70.41308546
73MAP3K50.39482345
74CHEK10.39235519
75TBK10.38889612
76PKN10.37272375
77PLK30.36732684
78ABL20.36682274
79RPS6KB20.35985747
80MYLK0.35714483
81CSNK2A10.35593054
82DAPK30.34798450
83OXSR10.33549627
84BRSK20.33393106
85CDK150.32858959
86IRAK10.32164973
87CDK180.31575608
88MELK0.31106035
89CSNK2A20.28956141
90MAP3K10.28463180
91DYRK30.27461254
92ATM0.26964407
93EEF2K0.26422146
94MUSK0.26230873
95BMPR20.26062013
96CDC70.25848416
97ZAP700.25842208
98BMPR1B0.25472359
99RPS6KB10.24381660
100NME10.22663931

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.09720249
2Proteasome_Homo sapiens_hsa030502.96226180
3N-Glycan biosynthesis_Homo sapiens_hsa005102.90835717
4Ribosome_Homo sapiens_hsa030102.87496605
5Sulfur relay system_Homo sapiens_hsa041222.85829634
6DNA replication_Homo sapiens_hsa030302.42211764
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34145721
8Sulfur metabolism_Homo sapiens_hsa009202.30561007
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.14737071
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09855315
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06868602
12Arginine biosynthesis_Homo sapiens_hsa002201.98586408
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98397399
14Drug metabolism - other enzymes_Homo sapiens_hsa009831.82444219
15Biosynthesis of amino acids_Homo sapiens_hsa012301.75481826
16Vitamin B6 metabolism_Homo sapiens_hsa007501.74630061
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73114501
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.71145259
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69535993
20Pyrimidine metabolism_Homo sapiens_hsa002401.68709968
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.65265349
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58161871
23RNA polymerase_Homo sapiens_hsa030201.57025607
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.55193899
25One carbon pool by folate_Homo sapiens_hsa006701.55060209
26Mismatch repair_Homo sapiens_hsa034301.54746510
27Complement and coagulation cascades_Homo sapiens_hsa046101.53785396
28Phenylalanine metabolism_Homo sapiens_hsa003601.53778984
29Base excision repair_Homo sapiens_hsa034101.47417246
30Carbon metabolism_Homo sapiens_hsa012001.46632210
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43927122
32Pyruvate metabolism_Homo sapiens_hsa006201.42707424
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41859339
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39804205
35Pentose phosphate pathway_Homo sapiens_hsa000301.38892560
36Fatty acid elongation_Homo sapiens_hsa000621.33956059
37Retinol metabolism_Homo sapiens_hsa008301.31991654
38Peroxisome_Homo sapiens_hsa041461.31716430
39RNA transport_Homo sapiens_hsa030131.31693090
40Systemic lupus erythematosus_Homo sapiens_hsa053221.26514874
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23016190
42Prion diseases_Homo sapiens_hsa050201.22870068
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22676055
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22610525
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20999449
46Parkinsons disease_Homo sapiens_hsa050121.18543549
47Nucleotide excision repair_Homo sapiens_hsa034201.16440932
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12144796
49Folate biosynthesis_Homo sapiens_hsa007901.11564356
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10055111
51Oxidative phosphorylation_Homo sapiens_hsa001901.07579261
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06279162
53Tyrosine metabolism_Homo sapiens_hsa003501.06245238
54Chemical carcinogenesis_Homo sapiens_hsa052041.02643595
55Other glycan degradation_Homo sapiens_hsa005110.97356512
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94238314
57Selenocompound metabolism_Homo sapiens_hsa004500.93202793
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92769491
59Alcoholism_Homo sapiens_hsa050340.89376679
60Protein export_Homo sapiens_hsa030600.86671167
61Non-homologous end-joining_Homo sapiens_hsa034500.86496031
62Arginine and proline metabolism_Homo sapiens_hsa003300.86099801
63Glutathione metabolism_Homo sapiens_hsa004800.84611028
64Huntingtons disease_Homo sapiens_hsa050160.84519150
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82659507
66Cell cycle_Homo sapiens_hsa041100.80511504
67Metabolic pathways_Homo sapiens_hsa011000.78973853
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77714060
69Purine metabolism_Homo sapiens_hsa002300.73691469
70Vibrio cholerae infection_Homo sapiens_hsa051100.73078746
71Bile secretion_Homo sapiens_hsa049760.72360719
72Homologous recombination_Homo sapiens_hsa034400.71999924
73Fanconi anemia pathway_Homo sapiens_hsa034600.67402743
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66564600
75Apoptosis_Homo sapiens_hsa042100.63042745
76Galactose metabolism_Homo sapiens_hsa000520.63014900
77Basal transcription factors_Homo sapiens_hsa030220.61608999
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.59347790
79beta-Alanine metabolism_Homo sapiens_hsa004100.58780852
80Lysosome_Homo sapiens_hsa041420.57217275
81Spliceosome_Homo sapiens_hsa030400.57000513
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56531763
83Starch and sucrose metabolism_Homo sapiens_hsa005000.56034499
84Sphingolipid metabolism_Homo sapiens_hsa006000.52703547
85Tryptophan metabolism_Homo sapiens_hsa003800.49221453
86mRNA surveillance pathway_Homo sapiens_hsa030150.49215931
87p53 signaling pathway_Homo sapiens_hsa041150.44554311
88Alzheimers disease_Homo sapiens_hsa050100.43721395
89Steroid biosynthesis_Homo sapiens_hsa001000.42858227
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41352314
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41048083
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40528742
93Histidine metabolism_Homo sapiens_hsa003400.39366916
94Fructose and mannose metabolism_Homo sapiens_hsa000510.38204894
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37861990
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37555898
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33522630
98Viral carcinogenesis_Homo sapiens_hsa052030.30754050
99Propanoate metabolism_Homo sapiens_hsa006400.29549598
100Collecting duct acid secretion_Homo sapiens_hsa049660.27621044

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