PADI4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of apoptotic cell clearance (GO:2000425)8.84220367
2lipoxygenase pathway (GO:0019372)7.76740525
3regulation of integrin activation (GO:0033623)6.91448836
4leukocyte migration involved in inflammatory response (GO:0002523)6.75699622
5production of molecular mediator involved in inflammatory response (GO:0002532)6.58874582
6cellular extravasation (GO:0045123)6.56939451
7regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.23461700
8mannose metabolic process (GO:0006013)6.04791519
9leukotriene metabolic process (GO:0006691)5.44317012
10complement activation, alternative pathway (GO:0006957)5.43802370
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.37210990
12negative regulation of cell killing (GO:0031342)5.37210990
13germinal center formation (GO:0002467)5.34353825
14defense response to fungus (GO:0050832)5.18760943
15leukocyte aggregation (GO:0070486)5.11707632
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.05345749
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.05345749
18regulation of B cell receptor signaling pathway (GO:0050855)4.90316850
19apoptotic cell clearance (GO:0043277)4.89007699
20respiratory burst (GO:0045730)4.88278443
21response to peptidoglycan (GO:0032494)4.62814153
22negative regulation of granulocyte differentiation (GO:0030853)4.53588712
23neutrophil activation involved in immune response (GO:0002283)4.50122108
24macrophage activation involved in immune response (GO:0002281)4.45198455
25response to fungus (GO:0009620)4.41203002
26negative regulation of interleukin-12 production (GO:0032695)4.34430443
27positive regulation of T cell chemotaxis (GO:0010820)4.27112165
28regulation of T cell chemotaxis (GO:0010819)4.27112165
29leukotriene biosynthetic process (GO:0019370)4.20415412
30long-chain fatty acid biosynthetic process (GO:0042759)4.18631345
31microglial cell activation (GO:0001774)4.17899414
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.15714744
33response to host immune response (GO:0052572)4.15714744
34endothelial cell chemotaxis (GO:0035767)4.15678197
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14995214
36antigen processing and presentation of endogenous antigen (GO:0019883)4.14462375
37chronic inflammatory response (GO:0002544)4.14053859
38opsonization (GO:0008228)4.13390290
39detection of molecule of bacterial origin (GO:0032490)4.12629051
40negative regulation of lymphocyte mediated immunity (GO:0002707)4.09806287
41icosanoid biosynthetic process (GO:0046456)3.98777757
42fatty acid derivative biosynthetic process (GO:1901570)3.98777757
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.98172207
44myeloid cell activation involved in immune response (GO:0002275)3.96722586
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.94617755
46leukocyte degranulation (GO:0043299)3.90095448
47regulation of gamma-delta T cell activation (GO:0046643)3.89206309
48leukocyte cell-cell adhesion (GO:0007159)3.89182466
49negative regulation of erythrocyte differentiation (GO:0045647)3.87088189
50antigen processing and presentation via MHC class Ib (GO:0002475)3.85825372
51activated T cell proliferation (GO:0050798)3.85619439
52regulation of phagocytosis (GO:0050764)3.84229419
53detection of external biotic stimulus (GO:0098581)3.83781810
54regulation of interferon-beta biosynthetic process (GO:0045357)3.75713945
55response to host (GO:0075136)3.72448918
56response to host defenses (GO:0052200)3.72448918
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.72448918
58macrophage differentiation (GO:0030225)3.69496358
59positive regulation of cell adhesion mediated by integrin (GO:0033630)3.69253880
60neutrophil mediated immunity (GO:0002446)3.69112554
61neutrophil chemotaxis (GO:0030593)3.67657042
62response to interleukin-15 (GO:0070672)3.63716531
63macrophage activation (GO:0042116)3.59636677
64neutrophil migration (GO:1990266)3.57093183
65negative regulation of leukocyte mediated immunity (GO:0002704)3.56441012
66regulation of T cell migration (GO:2000404)3.54293823
67regulation of leukocyte degranulation (GO:0043300)3.53399539
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.50095407
69positive regulation of B cell differentiation (GO:0045579)3.49304538
70superoxide anion generation (GO:0042554)3.47963299
71regulation of B cell differentiation (GO:0045577)3.46683232
72positive regulation of mast cell degranulation (GO:0043306)3.46503738
73positive regulation of mast cell activation involved in immune response (GO:0033008)3.46503738
74defense response to protozoan (GO:0042832)3.44595489
75regulation of gamma-delta T cell differentiation (GO:0045586)3.43757952
76killing of cells of other organism (GO:0031640)3.43026346
77disruption of cells of other organism (GO:0044364)3.43026346
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.39964465
79negative regulation of phagocytosis (GO:0050765)3.38329539
80negative regulation of T cell mediated immunity (GO:0002710)3.38117078
81positive regulation of gamma-delta T cell activation (GO:0046645)3.37718507
82immunoglobulin mediated immune response (GO:0016064)3.36018044
83cytokine production involved in immune response (GO:0002367)3.34102765
84positive regulation of antigen processing and presentation (GO:0002579)3.32495662
85mast cell activation (GO:0045576)3.32027706
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31749580
87megakaryocyte development (GO:0035855)3.31273296
88positive regulation of Rap GTPase activity (GO:0032854)3.29667887
89cellular response to interleukin-15 (GO:0071350)3.28841505
90adaptation of signaling pathway (GO:0023058)3.27866743
91B cell receptor signaling pathway (GO:0050853)3.27858020
92negative regulation of interleukin-6 production (GO:0032715)3.26915350
93regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26637373
94myeloid leukocyte mediated immunity (GO:0002444)3.25282322
95oxygen transport (GO:0015671)3.25055103
96neutrophil activation (GO:0042119)3.24557752
97detection of other organism (GO:0098543)3.23817850
98positive regulation of mast cell activation (GO:0033005)3.23809935
99response to protozoan (GO:0001562)3.23454312
100negative regulation of T-helper cell differentiation (GO:0045623)3.23285561
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.23285561
102regulation of humoral immune response (GO:0002920)3.21786057
103regulation of mast cell degranulation (GO:0043304)3.20999133
104complement activation (GO:0006956)3.20907540
105detection of biotic stimulus (GO:0009595)3.20318033
106killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.19423475
107disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.19423475
108regulation of platelet aggregation (GO:0090330)3.19094966
109regulation of regulated secretory pathway (GO:1903305)3.18843462
110regulation of endothelial cell chemotaxis (GO:2001026)3.17870779
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.16213277
112regulation of mast cell activation (GO:0033003)3.13977809
113negative regulation of bone mineralization (GO:0030502)3.12409269
114arachidonic acid metabolic process (GO:0019369)3.11182708
115lymph node development (GO:0048535)3.09807390
116granulocyte chemotaxis (GO:0071621)3.08973675
117leukocyte tethering or rolling (GO:0050901)3.08190047
118B cell mediated immunity (GO:0019724)3.07021484
119regulation of macrophage chemotaxis (GO:0010758)3.05371062
120regulation of interleukin-6 biosynthetic process (GO:0045408)3.04981463
121granulocyte migration (GO:0097530)3.04676770
122response to muramyl dipeptide (GO:0032495)3.04392484
123myeloid leukocyte activation (GO:0002274)3.04177403
124detection of bacterium (GO:0016045)3.03077895
125regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03028006
126cyclooxygenase pathway (GO:0019371)3.02868375
127unsaturated fatty acid biosynthetic process (GO:0006636)3.01531185
128regulation of lymphocyte migration (GO:2000401)2.99183678
129positive regulation of toll-like receptor signaling pathway (GO:0034123)2.97794743
130regulation of mast cell activation involved in immune response (GO:0033006)2.97776324
131modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97292157
132positive regulation by organism of defense response of other organism involved in symbiotic interact2.97292157
133modulation by symbiont of host immune response (GO:0052553)2.97292157
134positive regulation by symbiont of host defense response (GO:0052509)2.97292157
135modulation by symbiont of host defense response (GO:0052031)2.97292157
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97292157
137regulation of granulocyte differentiation (GO:0030852)2.97192316
138negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.97029128
139phagocytosis (GO:0006909)2.95179072
140regulation of regulatory T cell differentiation (GO:0045589)2.93534283
141granulocyte activation (GO:0036230)2.92900495
142dendritic cell migration (GO:0036336)2.91753522
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88311197
144negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.85521318
145organ or tissue specific immune response (GO:0002251)2.83774898
146regulation of T-helper 2 cell differentiation (GO:0045628)2.82651288
147negative regulation of alpha-beta T cell activation (GO:0046636)2.82102754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.50120130
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.42317270
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.96969490
4MYB_21317192_ChIP-Seq_ERMYB_Mouse3.72719779
5SCL_19346495_ChIP-Seq_HPC-7_Human3.52047554
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.20248562
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.19674975
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.11542979
9VDR_21846776_ChIP-Seq_THP-1_Human3.05460969
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.96918488
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.88498115
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.76425239
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75843191
14SPI1_23547873_ChIP-Seq_NB4_Human2.75059145
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.61731241
16MYC_22102868_ChIP-Seq_BL_Human2.58758508
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.57677852
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54264573
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.53128284
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.43484416
21VDR_24763502_ChIP-Seq_THP-1_Human2.39310316
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35208657
23E2F7_22180533_ChIP-Seq_HELA_Human2.25549065
24* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.21359806
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.15166266
26SPI1_23127762_ChIP-Seq_K562_Human2.10083035
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09626773
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07101610
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.01051832
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.99076994
31MAF_26560356_Chip-Seq_TH1_Human1.99000477
32MYB_26560356_Chip-Seq_TH2_Human1.96030948
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94194364
34* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.93406521
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87732147
36UTX_26944678_Chip-Seq_JUKART_Human1.86491546
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82395465
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78578805
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77741651
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74870789
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71365027
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71232534
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68982080
44RUNX_20019798_ChIP-Seq_JUKART_Human1.64062603
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.62030943
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61946406
47GATA1_22025678_ChIP-Seq_K562_Human1.61747769
48MYB_26560356_Chip-Seq_TH1_Human1.59809071
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59784953
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59612146
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54976312
52* GATA3_26560356_Chip-Seq_TH2_Human1.53431106
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.51993770
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51757011
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49163675
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49049303
57* LXR_22292898_ChIP-Seq_THP-1_Human1.45635146
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41974602
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41037356
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39612983
61PU_27001747_Chip-Seq_BMDM_Mouse1.35319882
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34628564
63* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34529933
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31377332
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30665747
66MAF_26560356_Chip-Seq_TH2_Human1.30490261
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.29943173
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29834133
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29706056
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28681554
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25688856
72KDM2B_26808549_Chip-Seq_DND41_Human1.24977369
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24219230
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23104381
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21349239
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19264952
77VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17832345
78* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16188964
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11776996
80* SPI1_20517297_ChIP-Seq_HL60_Human1.11528656
81BCL6_27268052_Chip-Seq_Bcells_Human1.10597522
82GATA3_27048872_Chip-Seq_THYMUS_Human1.10376266
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09584488
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09476355
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09123109
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08005578
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.07941181
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07130227
89GATA1_19941826_ChIP-Seq_K562_Human1.04229221
90GATA2_19941826_ChIP-Seq_K562_Human1.04023865
91RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03040046
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00908240
93NCOR1_26117541_ChIP-Seq_K562_Human1.00789285
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98758656
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98660972
96* BCOR_27268052_Chip-Seq_Bcells_Human0.98187590
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97803953
98* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97081608
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97042212
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96995332
101GATA2_21666600_ChIP-Seq_HMVEC_Human0.96788230
102PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92338045
103FOXM1_23109430_ChIP-Seq_U2OS_Human0.91106916
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90788704
105SMRT_27268052_Chip-Seq_Bcells_Human0.90566356
106* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89866998
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89415718
108RACK7_27058665_Chip-Seq_MCF-7_Human0.89270116
109CTCF_21964334_ChIP-Seq_BJAB-B_Human0.89247336
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88547466
111VDR_24787735_ChIP-Seq_THP-1_Human0.88227948
112STAT1_20625510_ChIP-Seq_HELA_Human0.87524637
113P300_27268052_Chip-Seq_Bcells_Human0.87114600
114KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86284968
115* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85557372
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84250318
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83945477
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81940738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.51592158
2MP0000685_abnormal_immune_system3.33040712
3MP0003303_peritoneal_inflammation3.15714394
4MP0002419_abnormal_innate_immunity3.14046053
5MP0005025_abnormal_response_to3.10850508
6MP0009785_altered_susceptibility_to3.03323622
7MP0002396_abnormal_hematopoietic_system3.01158539
8MP0003724_increased_susceptibility_to2.98558753
9MP0005387_immune_system_phenotype2.85970989
10MP0001790_abnormal_immune_system2.85970989
11MP0005058_abnormal_lysosome_morphology2.83399902
12MP0001835_abnormal_antigen_presentation2.80059652
13MP0009278_abnormal_bone_marrow2.76765922
14MP0005464_abnormal_platelet_physiology2.72647092
15MP0002148_abnormal_hypersensitivity_rea2.59208905
16MP0005000_abnormal_immune_tolerance2.59166296
17MP0001533_abnormal_skeleton_physiology2.47950689
18MP0001800_abnormal_humoral_immune2.41034066
19MP0002452_abnormal_antigen_presenting2.36308751
20MP0004947_skin_inflammation2.34906178
21MP0002420_abnormal_adaptive_immunity2.27181428
22MP0001819_abnormal_immune_cell2.23705974
23MP0000465_gastrointestinal_hemorrhage2.19767111
24MP0003075_altered_response_to2.18443698
25MP0004808_abnormal_hematopoietic_stem2.11272068
26MP0009333_abnormal_splenocyte_physiolog2.07121505
27MP0002723_abnormal_immune_serum2.03680525
28MP0001545_abnormal_hematopoietic_system2.03009063
29MP0005397_hematopoietic_system_phenotyp2.03009063
30MP0002405_respiratory_system_inflammati2.01076853
31MP0001851_eye_inflammation2.00901682
32MP0003183_abnormal_peptide_metabolism1.99545839
33MP0008260_abnormal_autophagy1.87400152
34MP0002166_altered_tumor_susceptibility1.87311696
35MP0002398_abnormal_bone_marrow1.85716583
36MP0009840_abnormal_foam_cell1.84729237
37MP0000716_abnormal_immune_system1.84353288
38MP0005174_abnormal_tail_pigmentation1.81952190
39MP0000689_abnormal_spleen_morphology1.79748560
40MP0001845_abnormal_inflammatory_respons1.78807281
41MP0002933_joint_inflammation1.72213635
42MP0003172_abnormal_lysosome_physiology1.63758385
43MP0001853_heart_inflammation1.62355386
44MP0002722_abnormal_immune_system1.61616072
45MP0002429_abnormal_blood_cell1.59685147
46MP0000343_altered_response_to1.56127809
47MP0000490_abnormal_crypts_of1.51722303
48MP0003300_gastrointestinal_ulcer1.46012842
49MP0005671_abnormal_response_to1.44907230
50MP0010155_abnormal_intestine_physiology1.44652755
51MP0005023_abnormal_wound_healing1.41637498
52MP0002277_abnormal_respiratory_mucosa1.41429554
53MP0004381_abnormal_hair_follicle1.40692642
54MP0003566_abnormal_cell_adhesion1.35506398
55MP0001873_stomach_inflammation1.34538879
56MP0004510_myositis1.26874908
57MP0008469_abnormal_protein_level1.26830837
58MP0002006_tumorigenesis1.23603313
59MP0005390_skeleton_phenotype1.21951340
60MP0008004_abnormal_stomach_pH1.21934707
61MP0005083_abnormal_biliary_tract1.20054303
62MP0003705_abnormal_hypodermis_morpholog1.14123980
63MP0003656_abnormal_erythrocyte_physiolo1.11962830
64MP0003191_abnormal_cellular_cholesterol1.11400131
65MP0003448_altered_tumor_morphology1.08570088
66MP0001986_abnormal_taste_sensitivity1.07566543
67MP0005166_decreased_susceptibility_to1.07471910
68MP0005164_abnormal_response_to1.05859692
69MP0000858_altered_metastatic_potential1.03454604
70MP0000249_abnormal_blood_vessel1.01863940
71MP0006082_CNS_inflammation1.00717426
72MP0002998_abnormal_bone_remodeling1.00090773
73MP0003806_abnormal_nucleotide_metabolis0.99631045
74MP0001849_ear_inflammation0.98934464
75MP0009763_increased_sensitivity_to0.97968994
76MP0005075_abnormal_melanosome_morpholog0.97697620
77MP0003638_abnormal_response/metabolism_0.95188307
78MP0003045_fibrosis0.91954776
79MP0003866_abnormal_defecation0.91790912
80MP0000703_abnormal_thymus_morphology0.90743736
81MP0003763_abnormal_thymus_physiology0.86603707
82MP0004130_abnormal_muscle_cell0.85151417
83MP0003828_pulmonary_edema0.83732132
84MP0009765_abnormal_xenobiotic_induced0.81394182
85MP0001663_abnormal_digestive_system0.79910419
86MP0002095_abnormal_skin_pigmentation0.79044642
87MP0005377_hearing/vestibular/ear_phenot0.78582686
88MP0003878_abnormal_ear_physiology0.78582686
89MP0000767_abnormal_smooth_muscle0.78064973
90MP0005084_abnormal_gallbladder_morpholo0.76522718
91MP0002019_abnormal_tumor_incidence0.75520619
92MP0003690_abnormal_glial_cell0.74762027
93MP0005310_abnormal_salivary_gland0.73640077
94MP0009931_abnormal_skin_appearance0.72704513
95MP0004883_abnormal_blood_vessel0.70099802
96MP0010352_gastrointestinal_tract_polyps0.70089443
97MP0002132_abnormal_respiratory_system0.68808005
98MP0001764_abnormal_homeostasis0.67474561
99MP0009764_decreased_sensitivity_to0.67106535
100MP0001216_abnormal_epidermal_layer0.65045107
101MP0002877_abnormal_melanocyte_morpholog0.65020867
102MP0002138_abnormal_hepatobiliary_system0.64323783
103MP0000015_abnormal_ear_pigmentation0.63841790
104MP0003279_aneurysm0.63551645
105MP0008874_decreased_physiological_sensi0.63454431
106MP0001915_intracranial_hemorrhage0.62466066
107MP0005451_abnormal_body_composition0.62238035
108MP0008438_abnormal_cutaneous_collagen0.61855426
109MP0000604_amyloidosis0.61239639
110MP0002282_abnormal_trachea_morphology0.59533992
111MP0005319_abnormal_enzyme/_coenzyme0.57774280
112MP0003453_abnormal_keratinocyte_physiol0.54261606
113MP0000477_abnormal_intestine_morphology0.54015892
114MP0005076_abnormal_cell_differentiation0.53308188
115MP0004484_altered_response_of0.53257001
116MP0005167_abnormal_blood-brain_barrier0.52686669
117MP0001614_abnormal_blood_vessel0.51653146
118MP0005381_digestive/alimentary_phenotyp0.51388803
119MP0003795_abnormal_bone_structure0.51345002
120MP0003567_abnormal_fetal_cardiomyocyte0.50818108
121MP0002693_abnormal_pancreas_physiology0.50381554
122MP0000569_abnormal_digit_pigmentation0.50216163
123MP0005535_abnormal_body_temperature0.49215562
124MP0003011_delayed_dark_adaptation0.48810854

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.95004944
2Recurrent abscess formation (HP:0002722)6.84316631
3Eczematoid dermatitis (HP:0000976)6.45319566
4Recurrent gram-negative bacterial infections (HP:0005420)6.32101881
5Hypochromic microcytic anemia (HP:0004840)5.54250853
6Glomerulonephritis (HP:0000099)5.53443605
7Recurrent bacterial skin infections (HP:0005406)5.50876202
8Vacuolated lymphocytes (HP:0001922)5.01105273
9Retrobulbar optic neuritis (HP:0100654)4.74873961
10Optic neuritis (HP:0100653)4.74873961
11Abnormality of complement system (HP:0005339)4.49888967
12Abnormality of macrophages (HP:0004311)4.40867523
13Dysostosis multiplex (HP:0000943)4.29114829
14Abnormality of the heme biosynthetic pathway (HP:0010472)4.24293069
15Nasal polyposis (HP:0100582)4.11907637
16Hypochromic anemia (HP:0001931)4.09108783
17Pustule (HP:0200039)4.06058164
18Abnormality of the nasal mucosa (HP:0000433)4.03810729
19Complement deficiency (HP:0004431)3.92267684
20Encephalitis (HP:0002383)3.78855580
21Spondylolisthesis (HP:0003302)3.77026597
22Abnormal platelet volume (HP:0011876)3.70951092
23Prolonged bleeding time (HP:0003010)3.65537764
24Gingivitis (HP:0000230)3.59511357
25Mucopolysacchariduria (HP:0008155)3.58124226
26Urinary glycosaminoglycan excretion (HP:0003541)3.58124226
27Keratoconjunctivitis sicca (HP:0001097)3.56902822
28Mediastinal lymphadenopathy (HP:0100721)3.55694278
29Obstructive lung disease (HP:0006536)3.52607508
30Chronic obstructive pulmonary disease (HP:0006510)3.52607508
31Chronic otitis media (HP:0000389)3.50158304
32Myositis (HP:0100614)3.47968694
33Cellulitis (HP:0100658)3.40255295
34Episodic fever (HP:0001954)3.39602748
35Recurrent fungal infections (HP:0002841)3.39151052
36Keratoconjunctivitis (HP:0001096)3.36612722
37Recurrent skin infections (HP:0001581)3.33713343
38Abnormality of mucopolysaccharide metabolism (HP:0011020)3.32530069
39Abnormality of polysaccharide metabolism (HP:0011012)3.32530069
40Abnormality of glycosaminoglycan metabolism (HP:0004371)3.32530069
41IgM deficiency (HP:0002850)3.32467572
42Loss of speech (HP:0002371)3.32177055
43Cervical subluxation (HP:0003308)3.28458114
44Nephritis (HP:0000123)3.23475614
45Microcytic anemia (HP:0001935)3.23444158
46Vasculitis (HP:0002633)3.22386821
47Chest pain (HP:0100749)3.11462202
48Periodontitis (HP:0000704)3.08277533
49Menorrhagia (HP:0000132)3.06932784
50Elevated erythrocyte sedimentation rate (HP:0003565)3.01424076
51J-shaped sella turcica (HP:0002680)2.98584365
52Petechiae (HP:0000967)2.98041213
53Spontaneous hematomas (HP:0007420)2.96243300
54Increased mean platelet volume (HP:0011877)2.92535060
55Epistaxis (HP:0000421)2.88830281
56Anorexia (HP:0002039)2.88709313
57Asymmetric septal hypertrophy (HP:0001670)2.86056936
58Hemoptysis (HP:0002105)2.80608814
59Thoracic kyphosis (HP:0002942)2.80218923
60Shallow orbits (HP:0000586)2.76480333
61Joint stiffness (HP:0001387)2.75135787
62Polygenic inheritance (HP:0010982)2.72031731
63Pulmonary infiltrates (HP:0002113)2.67615927
64Meningitis (HP:0001287)2.65710408
65Deformed sella turcica (HP:0002681)2.64671734
66Granulocytopenia (HP:0001913)2.64452232
67Peritonitis (HP:0002586)2.62728258
68Urticaria (HP:0001025)2.61287818
69Abnormality of iron homeostasis (HP:0011031)2.59697940
70Increased IgM level (HP:0003496)2.56591032
71Pulmonary embolism (HP:0002204)2.56044997
72Enlarged penis (HP:0000040)2.54913511
73Abnormality of the lumbar spine (HP:0100712)2.54138926
74Panhypogammaglobulinemia (HP:0003139)2.53132809
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.50242613
76Interstitial pulmonary disease (HP:0006530)2.49855133
77Broad face (HP:0000283)2.46963753
78T lymphocytopenia (HP:0005403)2.46619709
79Abnormality of T cells (HP:0002843)2.46594478
80Abnormality of T cell number (HP:0011839)2.45912669
81Increased cerebral lipofuscin (HP:0011813)2.44158843
82Orchitis (HP:0100796)2.42627664
83Toxemia of pregnancy (HP:0100603)2.39486239
84Thickened calvaria (HP:0002684)2.37910648
85Wrist flexion contracture (HP:0001239)2.37302137
86Recurrent viral infections (HP:0004429)2.35236895
87Increased neuronal autofluorescent lipopigment (HP:0002074)2.35134821
88Amyloidosis (HP:0011034)2.34259567
89Polycythemia (HP:0001901)2.30987488
90Sepsis (HP:0100806)2.25986766
91Abnormality of transition element cation homeostasis (HP:0011030)2.25325262
92Thrombocytosis (HP:0001894)2.24641427
93Increased serum ferritin (HP:0003281)2.24270052
94Gastrointestinal infarctions (HP:0005244)2.22224610
95Gangrene (HP:0100758)2.21620330
96Inflammation of the large intestine (HP:0002037)2.21419420
97Beaking of vertebral bodies (HP:0004568)2.19928317
98Gastrointestinal inflammation (HP:0004386)2.19920908
99Increased IgE level (HP:0003212)2.19545241
100Eosinophilia (HP:0001880)2.19274072
101Gingival bleeding (HP:0000225)2.19198904
102Abnormal hemoglobin (HP:0011902)2.18567320
103Abnormality of the thoracic spine (HP:0100711)2.17055683
104Hypergammaglobulinemia (HP:0010702)2.15677483
105Vertigo (HP:0002321)2.15462956
106Abnormality of the pleura (HP:0002103)2.14283568
10711 pairs of ribs (HP:0000878)2.12601952
108Reticulocytopenia (HP:0001896)2.07233775
109Abnormality of the common coagulation pathway (HP:0010990)2.05169236
110Impaired platelet aggregation (HP:0003540)2.02888020
111Abnormal platelet function (HP:0011869)2.02888020
112Poikilocytosis (HP:0004447)2.02872689
113Chronic mucocutaneous candidiasis (HP:0002728)2.01198275
114Recurrent cutaneous fungal infections (HP:0011370)2.01198275
115Lymphopenia (HP:0001888)2.00455286
116Bruising susceptibility (HP:0000978)2.00266947
117Arthropathy (HP:0003040)1.98052027
118Multifactorial inheritance (HP:0001426)1.96730935
119Abnormality of the pericardium (HP:0001697)1.96618781
120Arterial thrombosis (HP:0004420)1.96379380
121Skin ulcer (HP:0200042)1.96147269
122Joint swelling (HP:0001386)1.95785068
123Glomerulopathy (HP:0100820)1.93880871
124Keratitis (HP:0000491)1.92128547
125Leukocytosis (HP:0001974)1.91969987
126Skin rash (HP:0000988)1.90852285
127Thrombophlebitis (HP:0004418)1.90829358
128Acute hepatic failure (HP:0006554)1.90792890
129Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89973883
130Progressive neurologic deterioration (HP:0002344)1.89377414
131Hematochezia (HP:0002573)1.89212690
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.85935544
133Colitis (HP:0002583)1.85387745
134Abnormality of the endocardium (HP:0004306)1.84984955
135Radial bowing (HP:0002986)1.84484145
136Papilloma (HP:0012740)1.84062700
137Verrucae (HP:0200043)1.84062700
138Acne (HP:0001061)1.83835685
139Hand muscle atrophy (HP:0009130)1.83413331
140Osteomyelitis (HP:0002754)1.83003337
141Abnormality of eosinophils (HP:0001879)1.82928065
142Purpura (HP:0000979)1.80313781
143Autoimmune hemolytic anemia (HP:0001890)1.80267015
144Abnormality of the peritoneum (HP:0002585)1.80227502
145Cerebral aneurysm (HP:0004944)1.78355129
146Poor head control (HP:0002421)1.77186108
147Stomatitis (HP:0010280)1.75269870
148Hepatosplenomegaly (HP:0001433)1.74193591
149Abnormality of skull ossification (HP:0002703)1.73991826
150Ulnar deviation of the wrist (HP:0003049)1.73815661
151Deep venous thrombosis (HP:0002625)1.73774129
152Joint hemorrhage (HP:0005261)1.73524577
153Abnormality of T cell physiology (HP:0011840)1.72519547
154Abnormality of the sella turcica (HP:0002679)1.71442376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.24869195
2BLK3.93577023
3MAP4K13.51881319
4IRAK43.20696953
5ERN13.03736271
6EPHB12.60200202
7PKN22.51514997
8FES2.45367255
9KIT2.44493347
10TRIB32.43834664
11BTK2.38685429
12FLT32.11974977
13GRK62.08456770
14EEF2K2.07950908
15MAP2K32.06520929
16TAOK32.00605511
17TAOK11.92843624
18TEC1.91568102
19CAMK1D1.85195668
20CSF1R1.84077666
21ZAP701.77800629
22TGFBR21.77271959
23RIPK41.72043622
24STK101.65219614
25RIPK11.64725907
26HCK1.57358538
27FGR1.56093325
28CSK1.54689110
29TYK21.51852455
30LRRK21.51733328
31MAP3K111.47845230
32PRPF4B1.47007772
33TBK11.39763577
34SYK1.33258618
35PTK2B1.23007808
36CLK11.22748777
37SIK31.20974948
38CAMK1G1.19745562
39MAP3K141.18187194
40MET1.15269865
41PTK61.14463661
42TRPM71.14039683
43YES11.13247092
44MATK1.12617169
45IRAK11.09242111
46TTN1.07193751
47BMX1.06027446
48TXK1.05205415
49PIK3CG1.04885580
50LCK1.02361518
51BMPR20.99500627
52TGFBR10.99318054
53TAOK20.98930899
54NME20.94818813
55PAK40.94094829
56KSR20.92162430
57JAK30.90294349
58MAP3K120.88933029
59CAMKK20.88067573
60MAP3K60.87986254
61MAPKAPK30.87239214
62RPS6KA40.85326834
63SIK20.83870225
64LYN0.83473762
65DAPK10.83000481
66DAPK20.82963805
67MAP2K40.77037271
68MAP3K130.75975131
69PRKD20.75845126
70MARK20.75836538
71WEE10.73664799
72IKBKE0.73423445
73MAP3K50.73227270
74KDR0.72464647
75MAP2K60.72369179
76PRKG20.72203602
77PDPK10.70774652
78EPHA30.70648869
79RPS6KA60.69206588
80TESK20.66499910
81IRAK20.66489699
82RPS6KL10.66064681
83RPS6KC10.66064681
84CAMKK10.66039766
85PRKCH0.65420115
86PRKCQ0.63192040
87PIM10.58909589
88STK110.58849150
89IKBKB0.58375410
90RPS6KA20.56460754
91NEK20.55050803
92RPS6KB20.54137958
93MAPKAPK20.54007070
94EPHA20.50057820
95MAPK40.49824727
96PTK20.47317298
97MARK30.45711487
98RET0.45670176
99MAP3K20.45204864
100MAP3K70.45150769
101MAP3K30.44756906
102CDK190.44502148
103HIPK20.44086350
104MAP3K100.43692564
105RAF10.43579106
106IGF1R0.42903361
107DYRK1B0.42810717
108CDK70.42405262
109PIM20.42220163
110ALK0.41628529
111MAP3K10.41611126
112GRK50.41218492
113ADRBK10.40417189
114CDK40.40175120
115STK240.38952473
116NLK0.38924833
117CAMK10.38757859
118ITK0.38680303
119SGK30.38636761
120JAK10.37355619
121TNK20.37052035
122FYN0.36863558
123MAPKAPK50.35790965
124EGFR0.34483080
125MAPK70.34406578
126PRKCD0.32984905
127KSR10.32883173
128PRKCZ0.32745222
129MAPK120.32618908
130JAK20.32182577
131GRK70.32010656
132PRKD10.30710326
133PDK10.30261853
134SGK20.29710728
135ILK0.28345271
136ABL10.27537867
137ACVR1B0.26542369
138MAP2K20.25717735
139STK380.25355833
140OXSR10.23745361
141DYRK30.23696838

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.66312096
2Other glycan degradation_Homo sapiens_hsa005114.97682807
3Leishmaniasis_Homo sapiens_hsa051403.35522225
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.31960082
5Pertussis_Homo sapiens_hsa051333.14790876
6Caffeine metabolism_Homo sapiens_hsa002322.76711608
7Complement and coagulation cascades_Homo sapiens_hsa046102.64266901
8Graft-versus-host disease_Homo sapiens_hsa053322.08636511
9Allograft rejection_Homo sapiens_hsa053301.99253366
10Arachidonic acid metabolism_Homo sapiens_hsa005901.96473242
11Hematopoietic cell lineage_Homo sapiens_hsa046401.90332603
12Autoimmune thyroid disease_Homo sapiens_hsa053201.88170855
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.84781585
14Osteoclast differentiation_Homo sapiens_hsa043801.82444259
15Malaria_Homo sapiens_hsa051441.82421403
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68805318
17Legionellosis_Homo sapiens_hsa051341.67087901
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66279575
19African trypanosomiasis_Homo sapiens_hsa051431.60282209
20B cell receptor signaling pathway_Homo sapiens_hsa046621.54882450
21Lysosome_Homo sapiens_hsa041421.50475820
22Type I diabetes mellitus_Homo sapiens_hsa049401.46894999
23Tuberculosis_Homo sapiens_hsa051521.41982004
24Shigellosis_Homo sapiens_hsa051311.41336851
25Platelet activation_Homo sapiens_hsa046111.39326031
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36993814
27Chemokine signaling pathway_Homo sapiens_hsa040621.36322486
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35376632
29Acute myeloid leukemia_Homo sapiens_hsa052211.26468347
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.20968489
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18873197
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17056746
33Toxoplasmosis_Homo sapiens_hsa051451.16325342
34Linoleic acid metabolism_Homo sapiens_hsa005911.15956643
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14124660
36Amoebiasis_Homo sapiens_hsa051461.13392475
37Phagosome_Homo sapiens_hsa041451.05923256
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.05337113
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05000158
40Salmonella infection_Homo sapiens_hsa051321.03258028
41Herpes simplex infection_Homo sapiens_hsa051681.01526017
42Pentose phosphate pathway_Homo sapiens_hsa000301.01064262
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00940619
44Measles_Homo sapiens_hsa051621.00296385
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97927931
46Ribosome_Homo sapiens_hsa030100.97723158
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97293746
48Regulation of autophagy_Homo sapiens_hsa041400.96543016
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96508646
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96479955
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95764294
52Primary immunodeficiency_Homo sapiens_hsa053400.94944674
53DNA replication_Homo sapiens_hsa030300.92747026
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.91870704
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90590385
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86917746
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85670868
58Antigen processing and presentation_Homo sapiens_hsa046120.85331302
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85042954
60Collecting duct acid secretion_Homo sapiens_hsa049660.84503670
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83843051
62Influenza A_Homo sapiens_hsa051640.78982456
63Hepatitis B_Homo sapiens_hsa051610.77095008
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72952136
65Prion diseases_Homo sapiens_hsa050200.70815463
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70334591
67N-Glycan biosynthesis_Homo sapiens_hsa005100.69784488
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69738211
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67935603
70Chronic myeloid leukemia_Homo sapiens_hsa052200.67704924
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.67502606
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.66344760
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66097599
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.64820171
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64423385
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63345191
77Pancreatic cancer_Homo sapiens_hsa052120.63159057
78TNF signaling pathway_Homo sapiens_hsa046680.61996425
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61095783
80VEGF signaling pathway_Homo sapiens_hsa043700.60850960
81Apoptosis_Homo sapiens_hsa042100.60586950
82Renal cell carcinoma_Homo sapiens_hsa052110.60391521
83Choline metabolism in cancer_Homo sapiens_hsa052310.59419367
84Prolactin signaling pathway_Homo sapiens_hsa049170.57614240
85FoxO signaling pathway_Homo sapiens_hsa040680.57290750
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.57278079
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56964831
88Viral carcinogenesis_Homo sapiens_hsa052030.55362330
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54646023
90Type II diabetes mellitus_Homo sapiens_hsa049300.54408614
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53765534
92Histidine metabolism_Homo sapiens_hsa003400.52614650
93Sulfur relay system_Homo sapiens_hsa041220.50549283
94Dorso-ventral axis formation_Homo sapiens_hsa043200.49986847
95Viral myocarditis_Homo sapiens_hsa054160.49889723
96Hepatitis C_Homo sapiens_hsa051600.49800199
97Base excision repair_Homo sapiens_hsa034100.49684115
98Non-small cell lung cancer_Homo sapiens_hsa052230.49077468
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48535557
100Proteoglycans in cancer_Homo sapiens_hsa052050.48228551
101Small cell lung cancer_Homo sapiens_hsa052220.48214515
102ABC transporters_Homo sapiens_hsa020100.47329998
103Systemic lupus erythematosus_Homo sapiens_hsa053220.46875588
104Endometrial cancer_Homo sapiens_hsa052130.46815729
105Nitrogen metabolism_Homo sapiens_hsa009100.46109643
106Notch signaling pathway_Homo sapiens_hsa043300.46080957
107GnRH signaling pathway_Homo sapiens_hsa049120.45856526
108Galactose metabolism_Homo sapiens_hsa000520.43361808
109Rap1 signaling pathway_Homo sapiens_hsa040150.42560582
110Mismatch repair_Homo sapiens_hsa034300.41267989
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40757353
112Endocytosis_Homo sapiens_hsa041440.39298962
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.39295871
114Epstein-Barr virus infection_Homo sapiens_hsa051690.38960426
115MAPK signaling pathway_Homo sapiens_hsa040100.38229545
116Inositol phosphate metabolism_Homo sapiens_hsa005620.37919931
117Starch and sucrose metabolism_Homo sapiens_hsa005000.34897697
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33320767
119Pathways in cancer_Homo sapiens_hsa052000.33291210
120T cell receptor signaling pathway_Homo sapiens_hsa046600.32269653
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.32077351
122Rheumatoid arthritis_Homo sapiens_hsa053230.31782749
123Colorectal cancer_Homo sapiens_hsa052100.30398204
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.30376430
125HTLV-I infection_Homo sapiens_hsa051660.29770516
126mTOR signaling pathway_Homo sapiens_hsa041500.29199821
127Asthma_Homo sapiens_hsa053100.27831558
128Folate biosynthesis_Homo sapiens_hsa007900.26124031
129Insulin resistance_Homo sapiens_hsa049310.25603505
130HIF-1 signaling pathway_Homo sapiens_hsa040660.24962215
131Focal adhesion_Homo sapiens_hsa045100.23230356

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