PADI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)8.11749527
2one-carbon compound transport (GO:0019755)7.27106076
3keratinocyte differentiation (GO:0030216)7.13387205
4negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)7.01386111
5positive regulation of mitochondrial calcium ion concentration (GO:0051561)7.01142770
6hemidesmosome assembly (GO:0031581)6.67639915
7activation of Rac GTPase activity (GO:0032863)6.55862832
8lung lobe morphogenesis (GO:0060463)6.14686115
9positive regulation of osteoblast proliferation (GO:0033690)5.96047444
10epidermis development (GO:0008544)5.54920258
11epidermal cell differentiation (GO:0009913)5.27282977
12regulation of toll-like receptor 4 signaling pathway (GO:0034143)5.19281199
13maintenance of gastrointestinal epithelium (GO:0030277)5.11417383
14desmosome organization (GO:0002934)4.95264306
15regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.94482856
16positive regulation of respiratory burst (GO:0060267)4.86522460
17endoplasmic reticulum calcium ion homeostasis (GO:0032469)4.76769147
18positive regulation of Cdc42 GTPase activity (GO:0043089)4.61600972
19complement activation, alternative pathway (GO:0006957)4.60127197
20skin morphogenesis (GO:0043589)4.43490448
21peptide cross-linking (GO:0018149)4.41844188
22epithelial cell-cell adhesion (GO:0090136)4.39419589
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.38220622
24negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)4.36218590
25positive regulation of toll-like receptor signaling pathway (GO:0034123)4.33336317
26diterpenoid biosynthetic process (GO:0016102)4.32754952
27cell differentiation involved in embryonic placenta development (GO:0060706)4.31407128
28epithelial structure maintenance (GO:0010669)4.30526544
29adhesion of symbiont to host cell (GO:0044650)4.30120211
30virion attachment to host cell (GO:0019062)4.30120211
31decidualization (GO:0046697)4.25325205
32regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.18409648
33regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.14248936
34lung vasculature development (GO:0060426)4.13400730
35planar cell polarity pathway involved in neural tube closure (GO:0090179)4.08165014
36intermediate filament organization (GO:0045109)4.02202030
37muscle cell migration (GO:0014812)4.00770209
38atrioventricular valve morphogenesis (GO:0003181)3.98347733
39regulation of apoptotic cell clearance (GO:2000425)3.95416433
40keratinocyte proliferation (GO:0043616)3.94571906
41wound healing, spreading of epidermal cells (GO:0035313)3.93609746
42muscle organ morphogenesis (GO:0048644)3.91999587
43positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.90421840
44regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.90421840
45camera-type eye morphogenesis (GO:0048593)3.89807246
46positive regulation of astrocyte differentiation (GO:0048711)3.89441688
47regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.88107742
48branching involved in mammary gland duct morphogenesis (GO:0060444)3.83525994
49face development (GO:0060324)3.82503357
50positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.82314598
51myelin maintenance (GO:0043217)3.80175499
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.77737610
53regulation of water loss via skin (GO:0033561)3.76736947
54regulation of apoptotic process involved in morphogenesis (GO:1902337)3.75231719
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.74264955
56* citrulline biosynthetic process (GO:0019240)3.73510841
57positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.72229856
58positive regulation of extracellular matrix organization (GO:1903055)3.68801252
59branching involved in salivary gland morphogenesis (GO:0060445)3.65434568
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.64695269
61mitochondrial calcium ion homeostasis (GO:0051560)3.63662721
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60297132
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60297132
64gap junction assembly (GO:0016264)3.59160217
65negative regulation of cell fate specification (GO:0009996)3.56181160
66phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.54138935
67positive regulation of protein localization to plasma membrane (GO:1903078)3.53952021
68adhesion of symbiont to host (GO:0044406)3.53481488
69regulation of complement activation (GO:0030449)3.51449265
70regulation of respiratory burst (GO:0060263)3.51001024
71regulation of ruffle assembly (GO:1900027)3.50040223
72water homeostasis (GO:0030104)3.48574879
73hair follicle morphogenesis (GO:0031069)3.46098987
74phosphatidylserine metabolic process (GO:0006658)3.42455846
75phosphatidylinositol acyl-chain remodeling (GO:0036149)3.41220212
76establishment of skin barrier (GO:0061436)3.38266996
77cell-substrate junction assembly (GO:0007044)3.36584835
78mesodermal cell differentiation (GO:0048333)3.35843516
79positive regulation of macrophage differentiation (GO:0045651)3.35678744
80semaphorin-plexin signaling pathway (GO:0071526)3.34763383
81negative regulation of protein tyrosine kinase activity (GO:0061099)3.32670488
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.27675227
83response to host immune response (GO:0052572)3.27675227
84protein localization to endosome (GO:0036010)3.26693715
85cellular response to arsenic-containing substance (GO:0071243)3.25352967
86membrane raft organization (GO:0031579)3.22936662
87positive regulation of blood vessel endothelial cell migration (GO:0043536)3.21197483
88mammary gland epithelial cell proliferation (GO:0033598)3.20365679
89tyrosine phosphorylation of STAT protein (GO:0007260)3.19938353
90protein localization to microtubule (GO:0035372)3.16810110
91ectoderm development (GO:0007398)3.15784615
92regulation of protein activation cascade (GO:2000257)3.14149866
93bone remodeling (GO:0046849)3.13822487
94lung epithelium development (GO:0060428)3.13749113
95response to host (GO:0075136)3.13504040
96response to host defenses (GO:0052200)3.13504040
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.13504040
98positive regulation of hair cycle (GO:0042635)3.13292096
99positive regulation of hair follicle development (GO:0051798)3.13292096
100morphogenesis of embryonic epithelium (GO:0016331)3.13062873
101blood vessel remodeling (GO:0001974)3.11180901
1024-hydroxyproline metabolic process (GO:0019471)3.10429034
103regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.09553738
104regulation of cardioblast differentiation (GO:0051890)3.09482165
105negative regulation of complement activation (GO:0045916)3.09334534
106protein autoprocessing (GO:0016540)3.08299056
107positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.03804043
108regulation of viral release from host cell (GO:1902186)3.02947804
109ovulation from ovarian follicle (GO:0001542)3.02776646
110regulation of metalloenzyme activity (GO:0048552)3.00806449
111focal adhesion assembly (GO:0048041)2.97965308
112cell-substrate adherens junction assembly (GO:0007045)2.97965308
113opsonization (GO:0008228)2.97323127
114terpenoid biosynthetic process (GO:0016114)2.96843484
115regulation of transforming growth factor beta2 production (GO:0032909)2.95707855
116regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.95202436
117hypotonic response (GO:0006971)2.94142479
118O-glycan processing (GO:0016266)2.92744537
119plasma membrane repair (GO:0001778)2.92419010
120defense response to fungus (GO:0050832)2.91616330
121skin development (GO:0043588)2.90820524
122negative regulation of viral release from host cell (GO:1902187)2.90742246
123antigen processing and presentation of endogenous antigen (GO:0019883)2.90221422
124positive regulation of metanephros development (GO:0072216)2.87718205
125regulation of hair follicle development (GO:0051797)2.87638575
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86879827
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.86377878
128cytoskeletal anchoring at plasma membrane (GO:0007016)2.85392006
129positive regulation of pseudopodium assembly (GO:0031274)2.85084033
130positive regulation of p38MAPK cascade (GO:1900745)2.84883185
131tissue remodeling (GO:0048771)2.82802402
132wound healing, spreading of cells (GO:0044319)2.82687123
133establishment of protein localization to plasma membrane (GO:0090002)2.82333969
134dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82189410
135response to water (GO:0009415)2.79102695
136regulation of osteoblast proliferation (GO:0033688)2.78708292
137sulfate transmembrane transport (GO:1902358)2.77412995
138peptidyl-proline hydroxylation (GO:0019511)2.75992661
139regulation of hypersensitivity (GO:0002883)2.75935085
140regulation of Cdc42 GTPase activity (GO:0043088)2.75856927
141Golgi transport vesicle coating (GO:0048200)2.74870168
142COPI coating of Golgi vesicle (GO:0048205)2.74870168
143epithelium development (GO:0060429)2.74048565
144cell-cell junction assembly (GO:0007043)2.73482555
145multicellular organismal water homeostasis (GO:0050891)2.72765042
146trophoblast giant cell differentiation (GO:0060707)2.67300825
147establishment of planar polarity (GO:0001736)2.66887422
148establishment of tissue polarity (GO:0007164)2.66887422
149tight junction assembly (GO:0070830)2.66816650
150regulation of cholesterol homeostasis (GO:2000188)2.66585963
151positive regulation of Rac GTPase activity (GO:0032855)2.64465360
152apoptotic cell clearance (GO:0043277)2.63036473
153regulation of extracellular matrix organization (GO:1903053)2.62636780
154eyelid development in camera-type eye (GO:0061029)2.61488179
155positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61280080
156regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.60994571
157regulation of establishment of protein localization to plasma membrane (GO:0090003)2.60541634
158negative regulation of chondrocyte differentiation (GO:0032331)2.59713514
159gland morphogenesis (GO:0022612)2.59373347
160filopodium assembly (GO:0046847)2.59099311
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58437500
162alditol phosphate metabolic process (GO:0052646)2.56372919
163L-serine transport (GO:0015825)2.55770130
164phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.54148155
165detection of molecule of bacterial origin (GO:0032490)2.52364384
166L-fucose metabolic process (GO:0042354)2.51129659
167L-fucose catabolic process (GO:0042355)2.51129659
168fucose catabolic process (GO:0019317)2.51129659
169surfactant homeostasis (GO:0043129)2.51107733
170molting cycle (GO:0042303)12.5669961
171hair cycle (GO:0042633)12.5669961
172keratinization (GO:0031424)11.8107964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.30366145
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.90603426
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.40137608
4ESR1_15608294_ChIP-ChIP_MCF-7_Human3.51531287
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.41636790
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.06268973
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96056351
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.79127340
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.67851442
10ZNF263_19887448_ChIP-Seq_K562_Human2.27823062
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23103672
12CLOCK_20551151_ChIP-Seq_293T_Human2.15620168
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13527012
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09373705
15* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.01410144
16P63_26484246_Chip-Seq_KERATINOCYTES_Human1.97733800
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96250490
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95647658
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92886338
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92886338
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.89817562
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.85556438
23RACK7_27058665_Chip-Seq_MCF-7_Human1.84262843
24* SOX2_20726797_ChIP-Seq_SW620_Human1.84111853
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69125307
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68234147
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63645962
28* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63239025
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.63032379
30LXR_22292898_ChIP-Seq_THP-1_Human1.62789945
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62115848
32* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.61125345
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60369694
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.60214079
35ATF3_27146783_Chip-Seq_COLON_Human1.57641955
36* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.55157698
37ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.53435102
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.53347615
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47928723
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44233605
41SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44097270
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43401128
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.42568088
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41953644
45GATA4_25053715_ChIP-Seq_YYC3_Human1.38282325
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38157552
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34806965
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.33951082
49GATA3_24758297_ChIP-Seq_MCF-7_Human1.31244707
50* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26632135
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25676221
52* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24645180
53GATA1_19941826_ChIP-Seq_K562_Human1.23960405
54GATA6_25053715_ChIP-Seq_YYC3_Human1.23925147
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23893827
56KLF5_25053715_ChIP-Seq_YYC3_Human1.23803403
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.22970880
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22010607
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.21737396
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20300720
61CTCF_20526341_ChIP-Seq_ESCs_Human1.17708208
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16512691
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14320767
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.14151057
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14006250
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12190664
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11776835
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.10445136
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07978157
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07648271
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07097229
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05001965
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04797394
74CREB1_26743006_Chip-Seq_LNCaP_Human1.04109842
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00760665
76EGR1_19032775_ChIP-ChIP_M12_Human1.00419555
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00290146
78TP53_22127205_ChIP-Seq_IMR90_Human0.99650495
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99580477
80TCF7_22412390_ChIP-Seq_EML_Mouse0.98967500
81VDR_21846776_ChIP-Seq_THP-1_Human0.98898616
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98640524
83KDM2B_26808549_Chip-Seq_K562_Human0.98429780
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97455166
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97429948
86BCL6_27268052_Chip-Seq_Bcells_Human0.96796188
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96542889
88NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96018084
89* TP63_22573176_ChIP-Seq_HFKS_Human0.95475555
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95171547
91EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94462991
92* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92955403
93GATA2_19941826_ChIP-Seq_K562_Human0.91607091
94MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91292921
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90960222
96P68_20966046_ChIP-Seq_HELA_Human0.90217464
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90064345
98BCOR_27268052_Chip-Seq_Bcells_Human0.89369116
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88504883
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87324634
101* SMC4_20622854_ChIP-Seq_HELA_Human0.86492559
102AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86313207
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85972420
104* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85813897
105PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85488533
106ERG_20517297_ChIP-Seq_VCAP_Human0.84668405
107CJUN_26792858_Chip-Seq_BT549_Human0.84154924
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84052746
109* SA1_27219007_Chip-Seq_Bcells_Human0.83609470
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83261355
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82588695
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81846259
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81837911
114* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81333325
115SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81219020
116TP53_20018659_ChIP-ChIP_R1E_Mouse0.80980122
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.80857318
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.80787160
119AR_21909140_ChIP-Seq_LNCAP_Human0.80695318
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80650509
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80466607
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80087322
123* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79213132
124SA1_27219007_Chip-Seq_ERYTHROID_Human0.78917504
125* SCL_19346495_ChIP-Seq_HPC-7_Human0.78786208
126CTCF_27219007_Chip-Seq_Bcells_Human0.78699966
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78687630
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.78464369
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.78464369
130KDM2B_26808549_Chip-Seq_DND41_Human0.77037666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.31265379
2MP0002254_reproductive_system_inflammat4.88980776
3MP0002796_impaired_skin_barrier4.03808873
4MP0005275_abnormal_skin_tensile3.88940353
5MP0002098_abnormal_vibrissa_morphology3.88663815
6MP0010678_abnormal_skin_adnexa3.57666461
7MP0006054_spinal_hemorrhage3.21167544
8MP0000579_abnormal_nail_morphology3.14451172
9MP0000566_synostosis2.93467482
10MP0000383_abnormal_hair_follicle2.92008470
11MP0003705_abnormal_hypodermis_morpholog2.81241971
12MP0000647_abnormal_sebaceous_gland2.63865667
13MP0008438_abnormal_cutaneous_collagen2.53118142
14MP0005501_abnormal_skin_physiology2.50240535
15MP0004264_abnormal_extraembryonic_tissu2.45686275
16MP0003566_abnormal_cell_adhesion2.44678581
17MP0004885_abnormal_endolymph2.39435808
18MP0005377_hearing/vestibular/ear_phenot2.34490917
19MP0003878_abnormal_ear_physiology2.34490917
20MP0000377_abnormal_hair_follicle2.22189346
21MP0002060_abnormal_skin_morphology2.08579152
22MP0000537_abnormal_urethra_morphology2.03434967
23MP0001849_ear_inflammation2.01376731
24MP0004947_skin_inflammation1.99671469
25MP0001216_abnormal_epidermal_layer1.99574701
26MP0010030_abnormal_orbit_morphology1.94661329
27MP0005076_abnormal_cell_differentiation1.90562940
28MP0003453_abnormal_keratinocyte_physiol1.81153337
29MP0004272_abnormal_basement_membrane1.73421043
30MP0000427_abnormal_hair_cycle1.73244346
31MP0010771_integument_phenotype1.68949837
32MP0002877_abnormal_melanocyte_morpholog1.64723311
33MP0004043_abnormal_pH_regulation1.63833519
34MP0005670_abnormal_white_adipose1.55657705
35MP0010368_abnormal_lymphatic_system1.50715104
36MP0005083_abnormal_biliary_tract1.47838951
37MP0002234_abnormal_pharynx_morphology1.47587571
38MP0008004_abnormal_stomach_pH1.47108574
39MP0003436_decreased_susceptibility_to1.42438983
40MP0001666_abnormal_nutrient_absorption1.40949780
41MP0003045_fibrosis1.40201528
42MP0004019_abnormal_vitamin_homeostasis1.38482015
43MP0005167_abnormal_blood-brain_barrier1.36945286
44MP0005623_abnormal_meninges_morphology1.36540068
45MP0003866_abnormal_defecation1.34832766
46MP0001765_abnormal_ion_homeostasis1.29575346
47MP0000762_abnormal_tongue_morphology1.21354378
48MP0009785_altered_susceptibility_to1.20278899
49MP0001881_abnormal_mammary_gland1.19345050
50MP0009931_abnormal_skin_appearance1.18801507
51MP0001958_emphysema1.15677840
52MP0000627_abnormal_mammary_gland1.10815174
53MP0000467_abnormal_esophagus_morphology1.10687911
54MP0002249_abnormal_larynx_morphology1.08620626
55MP0000685_abnormal_immune_system1.05862398
56MP0000003_abnormal_adipose_tissue1.04943798
57MP0000367_abnormal_coat/_hair1.03715296
58MP0000681_abnormal_thyroid_gland1.03176063
59MP0005375_adipose_tissue_phenotype1.02694988
60MP0001243_abnormal_dermal_layer1.02581301
61MP0010352_gastrointestinal_tract_polyps0.98900274
62MP0003300_gastrointestinal_ulcer0.98761116
63MP0009053_abnormal_anal_canal0.96748255
64MP0001879_abnormal_lymphatic_vessel0.93218995
65MP0000733_abnormal_muscle_development0.92458863
66MP0001664_abnormal_digestion0.91735933
67MP0004185_abnormal_adipocyte_glucose0.89119564
68MP0005166_decreased_susceptibility_to0.88857375
69MP0003448_altered_tumor_morphology0.87239851
70MP0005023_abnormal_wound_healing0.87032357
71MP0009780_abnormal_chondrocyte_physiolo0.86186779
72MP0005409_darkened_coat_color0.85729132
73MP0000465_gastrointestinal_hemorrhage0.85403925
74MP0002933_joint_inflammation0.81851177
75MP0002138_abnormal_hepatobiliary_system0.80157789
76MP0002089_abnormal_postnatal_growth/wei0.79478669
77MP0005636_abnormal_mineral_homeostasis0.78115292
78MP0001727_abnormal_embryo_implantation0.77609322
79MP0004808_abnormal_hematopoietic_stem0.76492989
80MP0000751_myopathy0.76343252
81MP0001873_stomach_inflammation0.74591438
82MP0004883_abnormal_blood_vessel0.74442402
83MP0004742_abnormal_vestibular_system0.74355765
84MP0002909_abnormal_adrenal_gland0.73722790
85MP0000604_amyloidosis0.73450237
86MP0001340_abnormal_eyelid_morphology0.72393727
87MP0000477_abnormal_intestine_morphology0.71789861
88MP0000343_altered_response_to0.70705624
89MP0005164_abnormal_response_to0.70122889
90MP0001851_eye_inflammation0.70079861
91MP0009643_abnormal_urine_homeostasis0.69850386
92MP0000249_abnormal_blood_vessel0.67927839
93MP0000470_abnormal_stomach_morphology0.66653579
94MP0001348_abnormal_lacrimal_gland0.65947933
95MP0003075_altered_response_to0.65626319
96MP0000013_abnormal_adipose_tissue0.64618180
97MP0003315_abnormal_perineum_morphology0.64591533
98MP0001485_abnormal_pinna_reflex0.63975608
99MP0000613_abnormal_salivary_gland0.63525028
100MP0001661_extended_life_span0.63412287
101MP0005310_abnormal_salivary_gland0.63047159
102MP0003950_abnormal_plasma_membrane0.62959955
103MP0000534_abnormal_ureter_morphology0.62795021
104MP0005025_abnormal_response_to0.62623686
105MP0001915_intracranial_hemorrhage0.62120655
106MP0003191_abnormal_cellular_cholesterol0.61805285
107MP0001533_abnormal_skeleton_physiology0.61041816
108MP0004782_abnormal_surfactant_physiolog0.60340139
109MP0005197_abnormal_uvea_morphology0.59975868
110MP0005508_abnormal_skeleton_morphology0.59604114
111MP0005193_abnormal_anterior_eye0.59116423
112MP0010155_abnormal_intestine_physiology0.57678728
113MP0001191_abnormal_skin_condition0.57267288
114MP0003936_abnormal_reproductive_system0.57172440
115MP0002998_abnormal_bone_remodeling0.56993073
116MP0006138_congestive_heart_failure0.56788395
117MP0002282_abnormal_trachea_morphology0.55884550
118MP0000858_altered_metastatic_potential0.54878246
119MP0003638_abnormal_response/metabolism_0.54716489
120MP0005621_abnormal_cell_physiology0.54693025
121MP0008260_abnormal_autophagy0.54545350
122MP0002932_abnormal_joint_morphology0.53402077
123MP0010386_abnormal_urinary_bladder0.53362068
124MP0003115_abnormal_respiratory_system0.53144773
125MP0005595_abnormal_vascular_smooth0.52792963
126MP0000462_abnormal_digestive_system0.52406867
127MP0009333_abnormal_splenocyte_physiolog0.51992273
128MP0002086_abnormal_extraembryonic_tissu0.51710297
129MP0000678_abnormal_parathyroid_gland0.50732596
130MP0002111_abnormal_tail_morphology0.50356258
131MP0005666_abnormal_adipose_tissue0.49460203
132MP0004197_abnormal_fetal_growth/weight/0.49438000
133MP0000163_abnormal_cartilage_morphology0.48936033
134MP0002136_abnormal_kidney_physiology0.48739612
135MP0003091_abnormal_cell_migration0.48597146
136MP0005390_skeleton_phenotype0.48189323
137MP0003279_aneurysm0.48036417
138MP0000371_diluted_coat_color0.47172788
139MP0009764_decreased_sensitivity_to0.46785412
140MP0002419_abnormal_innate_immunity0.46664683
141MP0002168_other_aberrant_phenotype0.46653887
142MP0003755_abnormal_palate_morphology0.46480799
143MP0008875_abnormal_xenobiotic_pharmacok0.45777362

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.16652308
2Pili torti (HP:0003777)7.13248714
3Hypotrichosis (HP:0001006)6.31036553
4Woolly hair (HP:0002224)5.60811285
5Alopecia of scalp (HP:0002293)5.42036731
6Distal lower limb amyotrophy (HP:0008944)5.41526003
7Fragile nails (HP:0001808)5.37411683
8Milia (HP:0001056)4.92497424
9Nail dystrophy (HP:0008404)4.77776136
10Axonal loss (HP:0003447)4.58028562
11Abnormal hair laboratory examination (HP:0003328)4.53678977
12Right ventricular cardiomyopathy (HP:0011663)4.28856647
13Atrophic scars (HP:0001075)4.25330763
14Plantar hyperkeratosis (HP:0007556)4.18178637
15Abnormality of cochlea (HP:0000375)4.17004274
16Congenital sensorineural hearing impairment (HP:0008527)4.12294495
17Upper limb amyotrophy (HP:0009129)4.11709048
18Distal upper limb amyotrophy (HP:0007149)4.11709048
19Abnormality of hair growth rate (HP:0011363)3.83613794
20Slow-growing hair (HP:0002217)3.83613794
21Lower limb amyotrophy (HP:0007210)3.77616965
22Arterial tortuosity (HP:0005116)3.64488373
23Follicular hyperkeratosis (HP:0007502)3.62663300
24Brittle hair (HP:0002299)3.61393908
25Aortic dissection (HP:0002647)3.57454598
26Broad face (HP:0000283)3.41367952
27Vascular tortuosity (HP:0004948)3.37333520
28Hyperparathyroidism (HP:0000843)3.18928658
29Lip pit (HP:0100267)3.18078392
30Spondylolisthesis (HP:0003302)3.16398299
31Curly hair (HP:0002212)3.15294713
32Ankle contracture (HP:0006466)3.12323381
33Gout (HP:0001997)3.07053179
34Hyperactive renin-angiotensin system (HP:0000841)2.98091725
35Aortic aneurysm (HP:0004942)2.93684066
36Trismus (HP:0000211)2.90614019
37Erythroderma (HP:0001019)2.89522866
38Abnormality of nail color (HP:0100643)2.87406805
39Palmoplantar hyperkeratosis (HP:0000972)2.87122761
40Pustule (HP:0200039)2.86169886
41Corneal erosion (HP:0200020)2.84896523
42Pterygium (HP:0001059)2.83644722
43Ridged nail (HP:0001807)2.77000088
44Cerebral aneurysm (HP:0004944)2.75903937
45Morphological abnormality of the inner ear (HP:0011390)2.75389154
46Increased IgE level (HP:0003212)2.70381794
47Acanthosis nigricans (HP:0000956)2.65294798
48Palmar hyperkeratosis (HP:0010765)2.63837246
49Abnormal blistering of the skin (HP:0008066)2.62265390
50Radial bowing (HP:0002986)2.59968460
51Oligodontia (HP:0000677)2.57873918
52Premature rupture of membranes (HP:0001788)2.55571309
53Ectropion (HP:0000656)2.55422926
54Rectal prolapse (HP:0002035)2.54620526
55Abnormality of the distal phalanges of the toes (HP:0010182)2.52039668
56Short nail (HP:0001799)2.47923574
57Hyperacusis (HP:0010780)2.47890799
58Bowed forearm bones (HP:0003956)2.46855031
59Bowing of the arm (HP:0006488)2.46855031
60Sparse eyelashes (HP:0000653)2.46503266
61Renal salt wasting (HP:0000127)2.46316837
62Fragile skin (HP:0001030)2.45220634
63Bronchomalacia (HP:0002780)2.45127373
64Ulnar bowing (HP:0003031)2.44159695
65Increased connective tissue (HP:0009025)2.40431475
66Palmoplantar keratoderma (HP:0000982)2.39866513
67Choroideremia (HP:0001139)2.38709855
68Deep venous thrombosis (HP:0002625)2.34029643
69Abnormality of the nasal mucosa (HP:0000433)2.29888360
70Complement deficiency (HP:0004431)2.27761234
71Tracheal stenosis (HP:0002777)2.27172199
72Cervical subluxation (HP:0003308)2.26481128
73Chronic otitis media (HP:0000389)2.24303029
74Popliteal pterygium (HP:0009756)2.22836161
75Sparse scalp hair (HP:0002209)2.20705633
76Amelogenesis imperfecta (HP:0000705)2.18910746
77Ventricular tachycardia (HP:0004756)2.15824312
78Glucose intolerance (HP:0000833)2.14382655
79Glomerulonephritis (HP:0000099)2.13124570
80Thick nail (HP:0001805)2.12769274
81Type 1 muscle fiber predominance (HP:0003803)2.12435642
82Nasal polyposis (HP:0100582)2.12361448
83Multifactorial inheritance (HP:0001426)2.11304231
84Interstitial pulmonary disease (HP:0006530)2.11246463
85Dry hair (HP:0011359)2.08637394
86Polar cataract (HP:0010696)2.08032659
87Aortic regurgitation (HP:0001659)2.04992226
88Selective tooth agenesis (HP:0001592)2.01091020
89Abnormality of the gastric mucosa (HP:0004295)2.00953715
90Reduced subcutaneous adipose tissue (HP:0003758)2.00250649
91Abnormality of the salivary glands (HP:0010286)1.99957655
92Mitral valve prolapse (HP:0001634)1.99912944
93Erythema (HP:0010783)1.99388187
94Glomerulosclerosis (HP:0000096)1.97916997
95Hypoplasia of dental enamel (HP:0006297)1.96762344
96Congenital ichthyosiform erythroderma (HP:0007431)1.96470625
97Dehydration (HP:0001944)1.96451509
98Onion bulb formation (HP:0003383)1.94180621
99Oral leukoplakia (HP:0002745)1.92995989
100Abnormality of the frontal sinuses (HP:0002687)1.92051234
101Tubular atrophy (HP:0000092)1.89989757
102Aplasia cutis congenita (HP:0001057)1.89249017
103Nephritis (HP:0000123)1.89114192
104Split foot (HP:0001839)1.88724418
105Fine hair (HP:0002213)1.88676548
106Absent eyelashes (HP:0000561)1.87625299
107Blepharitis (HP:0000498)1.86256073
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.85803945
109Thin bony cortex (HP:0002753)1.85007667
110Tarsal synostosis (HP:0008368)1.84978091
111Abnormal vertebral ossification (HP:0100569)1.84145191
112Nuclear cataract (HP:0100018)1.81422304
113Dysostosis multiplex (HP:0000943)1.81350877
114Increased purine levels (HP:0004368)1.78355500
115Hyperuricemia (HP:0002149)1.78355500
116Systemic lupus erythematosus (HP:0002725)1.78313314
117Hemorrhage of the eye (HP:0011885)1.78283528
118Protrusio acetabuli (HP:0003179)1.78032984
119Obstructive sleep apnea (HP:0002870)1.75270416
120Elbow flexion contracture (HP:0002987)1.74499732
121Focal segmental glomerulosclerosis (HP:0000097)1.72897777
122Micronodular cirrhosis (HP:0001413)1.72348716
123Subacute progressive viral hepatitis (HP:0006572)1.72073626
124Flat acetabular roof (HP:0003180)1.70881720
125Anonychia (HP:0001798)1.69795103
126Aneurysm (HP:0002617)1.69600152
127Bicuspid aortic valve (HP:0001647)1.69173364
128Abnormality of complement system (HP:0005339)1.69040100
129Squamous cell carcinoma (HP:0002860)1.68682325
130Synostosis involving bones of the lower limbs (HP:0009138)1.68667314
131Synostosis involving bones of the feet (HP:0009140)1.68667314
132Mildly elevated creatine phosphokinase (HP:0008180)1.68516741
133Easy fatigability (HP:0003388)1.68207980
134Torticollis (HP:0000473)1.67875221
135Difficulty climbing stairs (HP:0003551)1.67849360
136Ureteral stenosis (HP:0000071)1.66833272
137Ankyloglossia (HP:0010296)1.66060248
138Polycythemia (HP:0001901)1.65599662
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63837421
140Distal lower limb muscle weakness (HP:0009053)1.63699028
141Vacuolated lymphocytes (HP:0001922)1.62489661
142Neonatal death (HP:0003811)1.61747590
143Increased cerebral lipofuscin (HP:0011813)1.61585157
144Osteolytic defects of the hand bones (HP:0009699)1.60770921
145Osteolytic defects of the phalanges of the hand (HP:0009771)1.60770921
146Chronic bronchitis (HP:0004469)1.59453704
147Foot dorsiflexor weakness (HP:0009027)1.59032947
148Hypohidrosis (HP:0000966)1.58678960
149Ventricular fibrillation (HP:0001663)1.58604323
150Goiter (HP:0000853)1.58426482
151Dilatation of the ascending aorta (HP:0005111)1.58318656
152Hyporeflexia of lower limbs (HP:0002600)1.57573146
153Cheilitis (HP:0100825)1.55880192
154Urinary glycosaminoglycan excretion (HP:0003541)1.55699588
155Mucopolysacchariduria (HP:0008155)1.55699588
156Spastic diplegia (HP:0001264)1.53437762
157Purpura (HP:0000979)1.52854002
158Advanced eruption of teeth (HP:0006288)1.52589978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.83858479
2EPHB22.91142334
3TGFBR22.77848962
4FER2.73931173
5TRIB32.56034044
6MST1R2.46429970
7EPHB12.39107691
8MAPKAPK32.33612329
9EEF2K2.06338822
10TIE12.03875580
11MAPK151.92595753
12PTK61.82815115
13PTK21.82419152
14IRAK31.73820674
15MST41.71850230
16FRK1.70480950
17RPS6KB21.68428285
18MAP3K21.68113845
19CDK81.61766858
20PAK41.60303691
21NME21.59214773
22PKN21.58824750
23ERN11.57493907
24LRRK21.56299930
25TTN1.52320427
26RIPK11.49320115
27EPHA31.46849367
28ZAP701.45331210
29LMTK21.35906688
30SIK11.33958127
31NTRK11.32752351
32TRPM71.32386815
33MAP3K31.24261706
34FGFR41.19705135
35ERBB31.19101998
36TBK11.16198558
37MYLK1.11852172
38ICK1.11780991
39BMX1.10050863
40MAP3K11.04816695
41MAP2K21.01166572
42PRKG20.98291094
43TGFBR10.94660364
44DDR20.94656178
45MAP3K90.94453773
46MET0.93536450
47FGFR30.91699091
48NLK0.90581918
49PAK20.83826716
50PHKG20.83170441
51PHKG10.83170441
52TAOK30.81341244
53MAP2K10.79507733
54FGFR10.78951510
55MAP3K100.77938972
56LATS10.77283525
57MAP2K30.76083523
58IKBKE0.74362595
59MAPKAPK50.74155299
60PDGFRA0.74095824
61PDGFRB0.71333069
62TYK20.71156703
63ERBB20.69120580
64MUSK0.68700597
65TESK10.67689995
66STK100.66140735
67KSR20.65279284
68MAP3K60.64764993
69LATS20.63971467
70CDK60.63493765
71MARK20.62892909
72PAK30.62833097
73MATK0.62691636
74PBK0.59473175
75RPS6KA40.58956560
76PIK3CG0.58367718
77TAOK10.57547927
78PTK2B0.56767685
79DMPK0.55577457
80STK240.55569879
81PRKCI0.55129543
82SRC0.54569359
83MAP3K70.54092916
84FGFR20.52226594
85NME10.52119070
86PRKD20.49505121
87JAK30.49445808
88PAK10.47333159
89JAK10.47056205
90FLT30.46845070
91HIPK20.46414342
92MAP2K60.46241002
93CDC42BPA0.45620267
94MAPKAPK20.45578352
95STK380.45058393
96PRKD10.44729326
97ALK0.41547261
98CDK90.41228424
99CSK0.40986464
100ARAF0.39444936
101MAP3K130.39397101
102MELK0.39153148
103CDK70.38400774
104KIT0.38109442
105MAP4K10.37182244
106EGFR0.37037461
107ILK0.36221731
108LIMK10.34908936
109RPS6KA10.33726906
110GSK3A0.33425584
111RET0.33412051
112CSNK1A1L0.33224723
113SMG10.32794509
114TSSK60.32539133
115NEK90.30719753
116MAP3K110.30281107
117KDR0.29657066
118HCK0.28431930
119MAP3K80.27875043
120BTK0.26757674
121RPS6KA20.25925541
122MTOR0.25383874
123CAMK1G0.23486376
124ROCK20.23373183
125JAK20.22771576
126NEK20.21406807
127CHUK0.19271573
128IRAK20.19191903
129EPHA40.18371297
130SIK30.17523438
131IGF1R0.14476200
132CSF1R0.14268507
133ERBB40.13645720
134AURKB0.12760989
135RPS6KL10.11943571
136RPS6KC10.11943571
137PDPK10.11864050
138DAPK10.11077083
139NEK60.10371616

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.95793840
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90852486
3Notch signaling pathway_Homo sapiens_hsa043302.88917115
4Linoleic acid metabolism_Homo sapiens_hsa005912.86268333
5Mineral absorption_Homo sapiens_hsa049782.66949300
6ECM-receptor interaction_Homo sapiens_hsa045122.63035263
7Staphylococcus aureus infection_Homo sapiens_hsa051502.44031490
8Galactose metabolism_Homo sapiens_hsa000522.35854755
9Fat digestion and absorption_Homo sapiens_hsa049752.25472424
10Phenylalanine metabolism_Homo sapiens_hsa003602.04778933
11Fructose and mannose metabolism_Homo sapiens_hsa000511.94277607
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92859198
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85145886
14Toxoplasmosis_Homo sapiens_hsa051451.82381235
15Amoebiasis_Homo sapiens_hsa051461.78520273
16Arachidonic acid metabolism_Homo sapiens_hsa005901.77945411
17Leishmaniasis_Homo sapiens_hsa051401.75305375
18Pertussis_Homo sapiens_hsa051331.68635015
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66710011
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.64046686
21Histidine metabolism_Homo sapiens_hsa003401.62243781
22Proteoglycans in cancer_Homo sapiens_hsa052051.59610900
23Axon guidance_Homo sapiens_hsa043601.59187343
24Small cell lung cancer_Homo sapiens_hsa052221.50843139
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.49475498
26Complement and coagulation cascades_Homo sapiens_hsa046101.49290556
27Focal adhesion_Homo sapiens_hsa045101.48702508
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48165019
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46391167
30Thyroid hormone synthesis_Homo sapiens_hsa049181.43100170
31Caffeine metabolism_Homo sapiens_hsa002321.40558958
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.33297287
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31990346
34Other glycan degradation_Homo sapiens_hsa005111.29393554
35Tight junction_Homo sapiens_hsa045301.29149688
36Adherens junction_Homo sapiens_hsa045201.27226021
37Hematopoietic cell lineage_Homo sapiens_hsa046401.22867365
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22730572
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20379513
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19882041
41Ether lipid metabolism_Homo sapiens_hsa005651.19863172
42Starch and sucrose metabolism_Homo sapiens_hsa005001.19089040
43Legionellosis_Homo sapiens_hsa051341.15282272
44Tyrosine metabolism_Homo sapiens_hsa003501.14686999
45Endocytosis_Homo sapiens_hsa041441.14038820
46Salivary secretion_Homo sapiens_hsa049701.12793969
47Antigen processing and presentation_Homo sapiens_hsa046121.10331804
48TNF signaling pathway_Homo sapiens_hsa046681.10214746
49Osteoclast differentiation_Homo sapiens_hsa043801.08139752
50Salmonella infection_Homo sapiens_hsa051321.07584835
51Lysosome_Homo sapiens_hsa041421.07539564
52VEGF signaling pathway_Homo sapiens_hsa043701.06898601
53Chronic myeloid leukemia_Homo sapiens_hsa052201.06837313
54Malaria_Homo sapiens_hsa051441.06248823
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.03266777
56Inositol phosphate metabolism_Homo sapiens_hsa005621.00094812
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99408197
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98914467
59Thyroid cancer_Homo sapiens_hsa052160.94829123
60Glutathione metabolism_Homo sapiens_hsa004800.93744739
61Renal cell carcinoma_Homo sapiens_hsa052110.93723546
62Hippo signaling pathway_Homo sapiens_hsa043900.91888006
63Sulfur relay system_Homo sapiens_hsa041220.91588801
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90677103
65Pancreatic cancer_Homo sapiens_hsa052120.89721309
66Insulin signaling pathway_Homo sapiens_hsa049100.89177141
67Shigellosis_Homo sapiens_hsa051310.87509131
68N-Glycan biosynthesis_Homo sapiens_hsa005100.86668256
69Platelet activation_Homo sapiens_hsa046110.86347303
70Circadian rhythm_Homo sapiens_hsa047100.85995127
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85942249
72Tuberculosis_Homo sapiens_hsa051520.85419120
73Hepatitis C_Homo sapiens_hsa051600.85149711
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.84123714
75Bladder cancer_Homo sapiens_hsa052190.82236510
76TGF-beta signaling pathway_Homo sapiens_hsa043500.81909317
77Pancreatic secretion_Homo sapiens_hsa049720.81348800
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81129198
79Retinol metabolism_Homo sapiens_hsa008300.77490816
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77430784
81Basal cell carcinoma_Homo sapiens_hsa052170.75834085
82Influenza A_Homo sapiens_hsa051640.73939589
83ErbB signaling pathway_Homo sapiens_hsa040120.72716366
84Apoptosis_Homo sapiens_hsa042100.72087874
85Estrogen signaling pathway_Homo sapiens_hsa049150.72000771
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71891783
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.68763275
88Pathways in cancer_Homo sapiens_hsa052000.68320322
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66741677
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66727004
91Acute myeloid leukemia_Homo sapiens_hsa052210.66407736
92beta-Alanine metabolism_Homo sapiens_hsa004100.66117782
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.65737960
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64652041
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64447057
96Insulin resistance_Homo sapiens_hsa049310.63917935
97HIF-1 signaling pathway_Homo sapiens_hsa040660.62317997
98Melanogenesis_Homo sapiens_hsa049160.61558597
99Vitamin B6 metabolism_Homo sapiens_hsa007500.61067881
100MicroRNAs in cancer_Homo sapiens_hsa052060.60516975
101Wnt signaling pathway_Homo sapiens_hsa043100.60508733
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.60007752
103Gastric acid secretion_Homo sapiens_hsa049710.59875641
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59754849
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59739236
106Hedgehog signaling pathway_Homo sapiens_hsa043400.58461925
107Rap1 signaling pathway_Homo sapiens_hsa040150.57929892
108Dilated cardiomyopathy_Homo sapiens_hsa054140.57837835
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57488520
110GnRH signaling pathway_Homo sapiens_hsa049120.56688708
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56541710
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55564317
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53983920
114Pentose phosphate pathway_Homo sapiens_hsa000300.53208002
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53086907
116Colorectal cancer_Homo sapiens_hsa052100.52979322
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52521588
118Vibrio cholerae infection_Homo sapiens_hsa051100.52239515
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51105119
120Ras signaling pathway_Homo sapiens_hsa040140.51039262
121Rheumatoid arthritis_Homo sapiens_hsa053230.50424992
122Protein digestion and absorption_Homo sapiens_hsa049740.48707923
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48190477
124Endometrial cancer_Homo sapiens_hsa052130.47912199
125Sphingolipid metabolism_Homo sapiens_hsa006000.47553795
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.45723240
127Chemical carcinogenesis_Homo sapiens_hsa052040.45278412
128HTLV-I infection_Homo sapiens_hsa051660.43669110
129Dorso-ventral axis formation_Homo sapiens_hsa043200.43416082
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.42827122
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.41692614
132B cell receptor signaling pathway_Homo sapiens_hsa046620.41635674
133Viral myocarditis_Homo sapiens_hsa054160.41558286
134Choline metabolism in cancer_Homo sapiens_hsa052310.37441059
135Viral carcinogenesis_Homo sapiens_hsa052030.36356522
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.36263830
137Glioma_Homo sapiens_hsa052140.36003771
138African trypanosomiasis_Homo sapiens_hsa051430.33773820
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31852585
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31248845
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30898675
142Biosynthesis of amino acids_Homo sapiens_hsa012300.30586092

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