PACRGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.71450076
2behavioral response to nicotine (GO:0035095)4.55218592
3piRNA metabolic process (GO:0034587)4.27002009
4fucose catabolic process (GO:0019317)4.09112615
5L-fucose metabolic process (GO:0042354)4.09112615
6L-fucose catabolic process (GO:0042355)4.09112615
7epithelial cilium movement (GO:0003351)4.07028392
8cilium or flagellum-dependent cell motility (GO:0001539)4.04334842
9axoneme assembly (GO:0035082)3.95790271
10cilium movement (GO:0003341)3.66120648
11kynurenine metabolic process (GO:0070189)3.64497559
12regulation of meiosis I (GO:0060631)3.59054804
13tryptophan catabolic process (GO:0006569)3.55646838
14indole-containing compound catabolic process (GO:0042436)3.55646838
15indolalkylamine catabolic process (GO:0046218)3.55646838
16intraciliary transport (GO:0042073)3.39826636
17response to pheromone (GO:0019236)3.37458541
18cilium morphogenesis (GO:0060271)3.36596187
19regulation of cilium movement (GO:0003352)3.36563863
20cilium organization (GO:0044782)3.34839526
21protein localization to cilium (GO:0061512)3.31008408
22cilium assembly (GO:0042384)3.27653621
23protein polyglutamylation (GO:0018095)3.26066460
24DNA methylation involved in gamete generation (GO:0043046)3.21172491
25indolalkylamine metabolic process (GO:0006586)3.20049579
26synapsis (GO:0007129)3.16105042
27axonemal dynein complex assembly (GO:0070286)3.15641053
28RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14562633
29nonmotile primary cilium assembly (GO:0035058)3.12631332
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11395588
31rRNA catabolic process (GO:0016075)3.09059126
32male meiosis I (GO:0007141)3.05628782
33tryptophan metabolic process (GO:0006568)3.02567556
34centriole replication (GO:0007099)3.00652954
35reciprocal meiotic recombination (GO:0007131)2.96683034
36reciprocal DNA recombination (GO:0035825)2.96683034
37photoreceptor cell maintenance (GO:0045494)2.92733153
38behavioral response to ethanol (GO:0048149)2.90784356
39establishment of protein localization to Golgi (GO:0072600)2.90128223
40neural tube formation (GO:0001841)2.87038228
41oxidative demethylation (GO:0070989)2.83540849
42retinal cone cell development (GO:0046549)2.83196153
43male meiosis (GO:0007140)2.82343062
44negative regulation of telomere maintenance (GO:0032205)2.81511307
45reflex (GO:0060004)2.80817721
46DNA double-strand break processing (GO:0000729)2.79340224
47neuronal action potential (GO:0019228)2.75479309
48somatic hypermutation of immunoglobulin genes (GO:0016446)2.72371988
49somatic diversification of immune receptors via somatic mutation (GO:0002566)2.72371988
50cellular ketone body metabolic process (GO:0046950)2.72212164
51water-soluble vitamin biosynthetic process (GO:0042364)2.71521881
52respiratory chain complex IV assembly (GO:0008535)2.71084803
53sperm motility (GO:0030317)2.67212594
54gamma-aminobutyric acid transport (GO:0015812)2.65671227
55replication fork processing (GO:0031297)2.63910568
56detection of light stimulus involved in visual perception (GO:0050908)2.63632197
57detection of light stimulus involved in sensory perception (GO:0050962)2.63632197
58multicellular organism reproduction (GO:0032504)2.60852496
59indole-containing compound metabolic process (GO:0042430)2.60225342
60cellular component assembly involved in morphogenesis (GO:0010927)2.59931436
61L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58015904
62cornea development in camera-type eye (GO:0061303)2.57868871
63recombinational repair (GO:0000725)2.57412998
64meiotic chromosome segregation (GO:0045132)2.56892875
65double-strand break repair via homologous recombination (GO:0000724)2.56697123
66sulfation (GO:0051923)2.55696096
67regulation of microtubule-based movement (GO:0060632)2.55603785
68preassembly of GPI anchor in ER membrane (GO:0016254)2.55068919
69platelet dense granule organization (GO:0060155)2.54330466
70negative regulation of DNA-dependent DNA replication (GO:2000104)2.53398888
71negative regulation of systemic arterial blood pressure (GO:0003085)2.50799548
72prenylation (GO:0097354)2.49960850
73protein prenylation (GO:0018342)2.49960850
74primary amino compound metabolic process (GO:1901160)2.49865122
75regulation of nuclear cell cycle DNA replication (GO:0033262)2.49229355
76ubiquinone metabolic process (GO:0006743)2.47613425
77acrosome reaction (GO:0007340)2.46726057
78ubiquinone biosynthetic process (GO:0006744)2.43553213
79kidney morphogenesis (GO:0060993)2.42797600
80DNA deamination (GO:0045006)2.41889503
81resolution of meiotic recombination intermediates (GO:0000712)2.40384795
82ketone body metabolic process (GO:1902224)2.40189332
83signal peptide processing (GO:0006465)2.39384554
84protein-cofactor linkage (GO:0018065)2.37914902
85motile cilium assembly (GO:0044458)2.37494089
86photoreceptor cell development (GO:0042461)2.36429743
87protein complex biogenesis (GO:0070271)2.36356612
88regulation of telomere maintenance (GO:0032204)2.36217545
89protein K11-linked deubiquitination (GO:0035871)2.35987237
90negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.35946448
91negative regulation of translation, ncRNA-mediated (GO:0040033)2.35946448
92regulation of translation, ncRNA-mediated (GO:0045974)2.35946448
93positive regulation of meiosis (GO:0045836)2.35829649
94smoothened signaling pathway (GO:0007224)2.35761233
95regulation of rhodopsin mediated signaling pathway (GO:0022400)2.32930969
96meiosis I (GO:0007127)2.32599353
97anterograde synaptic vesicle transport (GO:0048490)2.32598373
98regulation of hexokinase activity (GO:1903299)2.32426698
99regulation of glucokinase activity (GO:0033131)2.32426698
100positive regulation of mitochondrial fission (GO:0090141)2.32246524

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.77527175
2GBX2_23144817_ChIP-Seq_PC3_Human3.00800567
3VDR_22108803_ChIP-Seq_LS180_Human2.94938021
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81505912
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70494486
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69728998
7IGF1R_20145208_ChIP-Seq_DFB_Human2.63464751
8TAF15_26573619_Chip-Seq_HEK293_Human2.54067626
9FUS_26573619_Chip-Seq_HEK293_Human2.43105687
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.36798255
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.34862812
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34861444
13EWS_26573619_Chip-Seq_HEK293_Human2.33115206
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.20933086
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15188797
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13800412
17EZH2_22144423_ChIP-Seq_EOC_Human2.12701192
18P300_19829295_ChIP-Seq_ESCs_Human2.11839938
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01734763
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93851490
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91971692
22ER_23166858_ChIP-Seq_MCF-7_Human1.90127777
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83855220
24* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78676116
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78299624
26IRF1_19129219_ChIP-ChIP_H3396_Human1.71678196
27* STAT3_23295773_ChIP-Seq_U87_Human1.67266416
28SMAD4_21799915_ChIP-Seq_A2780_Human1.66419997
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65513078
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64763371
31CBP_20019798_ChIP-Seq_JUKART_Human1.64605070
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64605070
33* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54857026
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.54341108
35BCAT_22108803_ChIP-Seq_LS180_Human1.52538274
36AR_25329375_ChIP-Seq_VCAP_Human1.52211753
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50566259
38TCF4_23295773_ChIP-Seq_U87_Human1.49532718
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48010717
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47479615
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46496213
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44307190
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43499772
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41596358
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.40237848
46TP53_22573176_ChIP-Seq_HFKS_Human1.39645943
47MYC_18940864_ChIP-ChIP_HL60_Human1.37409380
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36460110
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.36052730
50TCF4_22108803_ChIP-Seq_LS180_Human1.35103412
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33390502
52RUNX2_22187159_ChIP-Seq_PCA_Human1.32829733
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32273136
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32051155
55TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31724337
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31724337
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30289506
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.30289506
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29703367
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29625111
61ELK1_19687146_ChIP-ChIP_HELA_Human1.29433244
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.27818142
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27220839
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27142816
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26117553
66NANOG_19829295_ChIP-Seq_ESCs_Human1.26033278
67SOX2_19829295_ChIP-Seq_ESCs_Human1.26033278
68RNF2_27304074_Chip-Seq_NSC_Mouse1.25275161
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.24338876
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23296822
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22776757
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.21458590
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20887528
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20774699
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.20583694
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.19102191
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.17647469
78REST_21632747_ChIP-Seq_MESCs_Mouse1.16386851
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.15857862
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15435810
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13104840
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.09520121
83AR_21572438_ChIP-Seq_LNCaP_Human1.09399136
84HOXB7_26014856_ChIP-Seq_BT474_Human1.07906163
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07835366
86TAL1_26923725_Chip-Seq_HPCs_Mouse1.07186075
87AR_20517297_ChIP-Seq_VCAP_Human1.06813936
88VDR_23849224_ChIP-Seq_CD4+_Human1.06112758
89P53_22387025_ChIP-Seq_ESCs_Mouse1.05816943
90NCOR_22424771_ChIP-Seq_293T_Human1.05134345
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04676000
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04531939
93CDX2_22108803_ChIP-Seq_LS180_Human1.04423040
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03667743
95GATA3_21878914_ChIP-Seq_MCF-7_Human1.03081191
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02117468
97JUN_21703547_ChIP-Seq_K562_Human1.01563582
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.01013334
99STAT3_18555785_Chip-Seq_ESCs_Mouse1.00754952
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98636372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.53429618
2MP0003195_calcinosis2.65028003
3MP0005551_abnormal_eye_electrophysiolog2.35821927
4MP0002102_abnormal_ear_morphology2.34264629
5MP0009046_muscle_twitch2.28504285
6MP0006072_abnormal_retinal_apoptosis2.18763147
7MP0002837_dystrophic_cardiac_calcinosis2.12584467
8MP0003787_abnormal_imprinting2.10151556
9MP0000569_abnormal_digit_pigmentation2.09581732
10MP0005253_abnormal_eye_physiology1.96099866
11MP0001968_abnormal_touch/_nociception1.94407588
12MP0008058_abnormal_DNA_repair1.93441985
13MP0004885_abnormal_endolymph1.92551758
14MP0004133_heterotaxia1.91862386
15MP0004147_increased_porphyrin_level1.85200753
16MP0000427_abnormal_hair_cycle1.84501423
17MP0005645_abnormal_hypothalamus_physiol1.82612084
18MP0009745_abnormal_behavioral_response1.79298732
19MP0005646_abnormal_pituitary_gland1.79208274
20MP0003646_muscle_fatigue1.76188828
21MP0003136_yellow_coat_color1.73118228
22MP0003890_abnormal_embryonic-extraembry1.70106060
23MP0006292_abnormal_olfactory_placode1.69437184
24MP0004142_abnormal_muscle_tone1.69267261
25MP0004043_abnormal_pH_regulation1.69242091
26MP0008872_abnormal_physiological_respon1.66169590
27MP0008875_abnormal_xenobiotic_pharmacok1.65925537
28MP0002272_abnormal_nervous_system1.64989432
29MP0002638_abnormal_pupillary_reflex1.63411174
30MP0003880_abnormal_central_pattern1.63007306
31MP0002736_abnormal_nociception_after1.62766918
32MP0001984_abnormal_olfaction1.61776735
33MP0006276_abnormal_autonomic_nervous1.51682327
34MP0002653_abnormal_ependyma_morphology1.51101379
35MP0000631_abnormal_neuroendocrine_gland1.48141325
36MP0002938_white_spotting1.44658441
37MP0001486_abnormal_startle_reflex1.42445840
38MP0001485_abnormal_pinna_reflex1.42076013
39MP0000383_abnormal_hair_follicle1.40754631
40MP0001501_abnormal_sleep_pattern1.39332993
41MP0002160_abnormal_reproductive_system1.37838921
42MP0001529_abnormal_vocalization1.37573681
43MP0002572_abnormal_emotion/affect_behav1.36497759
44MP0003718_maternal_effect1.36244326
45MP0003698_abnormal_male_reproductive1.33790483
46MP0001929_abnormal_gametogenesis1.32731454
47MP0003011_delayed_dark_adaptation1.29259818
48MP0000372_irregular_coat_pigmentation1.28258206
49MP0005410_abnormal_fertilization1.25283706
50MP0002210_abnormal_sex_determination1.23955334
51MP0005174_abnormal_tail_pigmentation1.23790921
52MP0010386_abnormal_urinary_bladder1.23167676
53MP0002557_abnormal_social/conspecific_i1.19903011
54MP0001986_abnormal_taste_sensitivity1.18010607
55MP0008995_early_reproductive_senescence1.17367061
56MP0005084_abnormal_gallbladder_morpholo1.17136369
57MP0004145_abnormal_muscle_electrophysio1.17115754
58MP0004215_abnormal_myocardial_fiber1.14906477
59MP0005389_reproductive_system_phenotype1.13710107
60MP0002876_abnormal_thyroid_physiology1.13620132
61MP0002064_seizures1.12844350
62MP0002067_abnormal_sensory_capabilities1.12373692
63MP0008057_abnormal_DNA_replication1.10962949
64MP0000778_abnormal_nervous_system1.09314708
65MP0004924_abnormal_behavior1.08875874
66MP0005386_behavior/neurological_phenoty1.08875874
67MP0000653_abnormal_sex_gland1.05962709
68MP0002063_abnormal_learning/memory/cond1.05829375
69MP0003937_abnormal_limbs/digits/tail_de1.05182987
70MP0002928_abnormal_bile_duct1.04886238
71MP0000647_abnormal_sebaceous_gland1.04469100
72MP0001970_abnormal_pain_threshold1.04322747
73MP0004742_abnormal_vestibular_system1.04043496
74MP0002735_abnormal_chemical_nociception1.02423249
75MP0001145_abnormal_male_reproductive1.02168376
76MP0002734_abnormal_mechanical_nocicepti1.01650494
77MP0003635_abnormal_synaptic_transmissio1.01041815
78MP0002751_abnormal_autonomic_nervous1.00729383
79MP0002234_abnormal_pharynx_morphology1.00514174
80MP0003119_abnormal_digestive_system1.00445084
81MP0001188_hyperpigmentation1.00037485
82MP0002733_abnormal_thermal_nociception0.99557648
83MP0003121_genomic_imprinting0.99530898
84MP0005195_abnormal_posterior_eye0.98186845
85MP0002184_abnormal_innervation0.93773094
86MP0005379_endocrine/exocrine_gland_phen0.93258646
87MP0002229_neurodegeneration0.93226319
88MP0008775_abnormal_heart_ventricle0.89799942
89MP0002752_abnormal_somatic_nervous0.89420748
90MP0002095_abnormal_skin_pigmentation0.88944148
91MP0002163_abnormal_gland_morphology0.87375534
92MP0002909_abnormal_adrenal_gland0.86145261
93MP0005391_vision/eye_phenotype0.85604993
94MP0001324_abnormal_eye_pigmentation0.85560296
95MP0008961_abnormal_basal_metabolism0.84171630
96MP0001905_abnormal_dopamine_level0.82530072
97MP0001963_abnormal_hearing_physiology0.82161622
98MP0010094_abnormal_chromosome_stability0.81684345
99MP0001293_anophthalmia0.81490707
100MP0000026_abnormal_inner_ear0.79579855

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.83771711
2Pancreatic fibrosis (HP:0100732)4.59672078
3True hermaphroditism (HP:0010459)4.33392294
4Abnormality of midbrain morphology (HP:0002418)4.32061759
5Molar tooth sign on MRI (HP:0002419)4.32061759
6Nephronophthisis (HP:0000090)4.16318319
7Medial flaring of the eyebrow (HP:0010747)3.69001675
8Abnormality of the renal medulla (HP:0100957)3.65305231
9Abnormality of the renal cortex (HP:0011035)3.46975477
10Cystic liver disease (HP:0006706)3.16566126
11Absent/shortened dynein arms (HP:0200106)3.14858952
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.14858952
13Congenital stationary night blindness (HP:0007642)3.08476673
14Gait imbalance (HP:0002141)3.04943367
15Attenuation of retinal blood vessels (HP:0007843)3.02913101
16Congenital primary aphakia (HP:0007707)3.02605046
17Chronic hepatic failure (HP:0100626)2.91906736
18Hyperventilation (HP:0002883)2.87752509
19Type II lissencephaly (HP:0007260)2.84955042
20Nephrogenic diabetes insipidus (HP:0009806)2.83998248
21Abnormality of alanine metabolism (HP:0010916)2.82795124
22Hyperalaninemia (HP:0003348)2.82795124
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82795124
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.77697844
25Tubular atrophy (HP:0000092)2.77307540
26Abnormal respiratory motile cilium morphology (HP:0005938)2.77003554
27Abnormal respiratory epithelium morphology (HP:0012253)2.77003554
28Sclerocornea (HP:0000647)2.75660524
29Abnormal ciliary motility (HP:0012262)2.68106009
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.63923170
31Abolished electroretinogram (ERG) (HP:0000550)2.51671078
32Genital tract atresia (HP:0001827)2.51464813
33Renal cortical cysts (HP:0000803)2.46162603
34Postaxial foot polydactyly (HP:0001830)2.44997703
35Gaze-evoked nystagmus (HP:0000640)2.42494561
36Vaginal atresia (HP:0000148)2.42014339
37Congenital hepatic fibrosis (HP:0002612)2.40977798
38Abnormal respiratory motile cilium physiology (HP:0012261)2.40313923
39Anencephaly (HP:0002323)2.40095749
40Inability to walk (HP:0002540)2.28481181
41Poor coordination (HP:0002370)2.28301762
42Abnormal rod and cone electroretinograms (HP:0008323)2.24879262
43Furrowed tongue (HP:0000221)2.24133086
44Preaxial hand polydactyly (HP:0001177)2.22393226
45Lissencephaly (HP:0001339)2.20684208
46Progressive inability to walk (HP:0002505)2.17993004
47Polydipsia (HP:0001959)2.17302498
48Abnormal drinking behavior (HP:0030082)2.17302498
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16679338
50Abnormal biliary tract physiology (HP:0012439)2.15630766
51Bile duct proliferation (HP:0001408)2.15630766
52Tubulointerstitial nephritis (HP:0001970)2.14465580
53Progressive cerebellar ataxia (HP:0002073)2.11080099
54Male pseudohermaphroditism (HP:0000037)2.08532312
55Cerebellar dysplasia (HP:0007033)2.05363947
56Keratoconus (HP:0000563)2.05170064
57Increased corneal curvature (HP:0100692)2.05170064
58Postaxial hand polydactyly (HP:0001162)2.04451200
59Protruding tongue (HP:0010808)2.01850974
60Tubulointerstitial abnormality (HP:0001969)1.99672648
61Genetic anticipation (HP:0003743)1.97517790
62Decreased central vision (HP:0007663)1.97202547
63Concave nail (HP:0001598)1.97045739
64Bony spicule pigmentary retinopathy (HP:0007737)1.92510269
65Abnormality of the labia minora (HP:0012880)1.91231645
66Broad-based gait (HP:0002136)1.90680883
67Occipital encephalocele (HP:0002085)1.88654442
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87498423
69Fair hair (HP:0002286)1.86318508
70Retinal dysplasia (HP:0007973)1.86179404
71Rhinitis (HP:0012384)1.86046376
72Pendular nystagmus (HP:0012043)1.84884011
73Volvulus (HP:0002580)1.81302374
74Oligodactyly (hands) (HP:0001180)1.81187500
75Hypothermia (HP:0002045)1.80734390
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80550545
77Patellar aplasia (HP:0006443)1.80336629
78Febrile seizures (HP:0002373)1.79265124
79Short tibia (HP:0005736)1.78428663
80Chorioretinal atrophy (HP:0000533)1.78229059
81Methylmalonic acidemia (HP:0002912)1.77726273
82Dandy-Walker malformation (HP:0001305)1.77581432
83Abnormality of macular pigmentation (HP:0008002)1.77432554
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.77214607
85Colon cancer (HP:0003003)1.77129641
86Large for gestational age (HP:0001520)1.76579328
87Narrow forehead (HP:0000341)1.76577627
88Polyuria (HP:0000103)1.76067196
89Astigmatism (HP:0000483)1.75787372
90Oculomotor apraxia (HP:0000657)1.72992840
91Sloping forehead (HP:0000340)1.72923021
92Constricted visual fields (HP:0001133)1.72855564
93Increased CSF lactate (HP:0002490)1.72684826
94Aganglionic megacolon (HP:0002251)1.71653835
95Aplasia/Hypoplasia of the patella (HP:0006498)1.70516791
96Specific learning disability (HP:0001328)1.69848562
97Optic nerve hypoplasia (HP:0000609)1.69618739
98Prominent nasal bridge (HP:0000426)1.69050038
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69005977
100Intestinal atresia (HP:0011100)1.68335079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.00864572
2MAP4K23.56980133
3BMPR1B3.19617333
4ZAK2.76431944
5PNCK2.75548958
6NUAK12.52044211
7ACVR1B2.43000434
8ADRBK22.28687715
9MAP3K42.27535896
10WNK32.27236395
11CASK2.17716642
12INSRR2.16574878
13TAOK32.07352968
14GRK11.84495520
15TLK11.70046970
16WNK41.69641198
17PINK11.62217881
18MKNK21.61874649
19OXSR11.55363508
20MAP2K71.43348082
21CDK191.43077651
22MAPK131.40778131
23PLK41.37149379
24TRIM281.35701523
25STK391.19479283
26PLK21.19338612
27BCR1.14644825
28MST41.14208685
29TNIK1.12674593
30CSNK1G21.11127939
31STK38L1.07649476
32TGFBR11.02298072
33CSNK1G10.99816915
34TSSK60.98127922
35ADRBK10.97361233
36MAPK150.96212081
37CSNK1G30.95750803
38PTK2B0.94910767
39MKNK10.94889709
40CAMKK20.94302780
41PRKCE0.92993555
42PRKCG0.90199242
43CSNK1A1L0.89565737
44PAK30.89565317
45DAPK20.88534583
46MUSK0.87528374
47NTRK30.86186009
48EIF2AK30.84042464
49ERBB30.82786328
50PLK30.81931129
51TIE10.80142226
52WEE10.79180534
53MARK10.77810717
54BCKDK0.77197784
55VRK10.75864821
56MAPKAPK30.74043602
57BRSK20.72318511
58AKT30.70599172
59STK30.65779737
60CAMK1G0.65173717
61DYRK20.64654701
62EPHA40.64381645
63PLK10.64105952
64PHKG10.60850619
65PHKG20.60850619
66TXK0.58184933
67MAPKAPK50.55756975
68NEK10.55503468
69MAP2K40.54801129
70TRPM70.52291864
71CAMK2A0.49686035
72PIK3CA0.48962428
73ATR0.46006577
74FGFR20.45467960
75TAF10.45361730
76DYRK30.45297645
77ATM0.44818254
78MAP2K60.44028018
79CHEK20.42405882
80IRAK10.42402347
81TEC0.40859645
82STK160.40591958
83RPS6KA50.39765322
84PRKCI0.38084991
85MET0.37493381
86CSNK1D0.36635477
87CSNK1A10.36240932
88CDK30.35450841
89NTRK20.33508734
90PRKACA0.32169191
91PRKG10.31997237
92TTK0.31722225
93FER0.31377603
94LATS10.31270775
95NEK20.31060467
96PKN10.30906033
97PRKCQ0.28256136
98STK240.28220687
99MAP3K120.27612705
100NLK0.27292972

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.73214039
2Caffeine metabolism_Homo sapiens_hsa002322.57232123
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43506818
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36382107
5Protein export_Homo sapiens_hsa030602.29689466
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.27545403
7Nicotine addiction_Homo sapiens_hsa050332.26967962
8Linoleic acid metabolism_Homo sapiens_hsa005912.22398060
9Selenocompound metabolism_Homo sapiens_hsa004502.19903206
10Nitrogen metabolism_Homo sapiens_hsa009102.16038859
11Basal transcription factors_Homo sapiens_hsa030222.15703475
12Butanoate metabolism_Homo sapiens_hsa006502.14750217
13Fanconi anemia pathway_Homo sapiens_hsa034602.05884455
14Homologous recombination_Homo sapiens_hsa034402.03952364
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02065987
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00067659
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.85950593
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82445891
19Propanoate metabolism_Homo sapiens_hsa006401.74605468
20Ether lipid metabolism_Homo sapiens_hsa005651.73844792
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72847530
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.67928811
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60270582
24Tryptophan metabolism_Homo sapiens_hsa003801.59734269
25RNA polymerase_Homo sapiens_hsa030201.59701812
26Taste transduction_Homo sapiens_hsa047421.58141763
27Oxidative phosphorylation_Homo sapiens_hsa001901.54267095
28RNA degradation_Homo sapiens_hsa030181.53815186
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48942633
30Non-homologous end-joining_Homo sapiens_hsa034501.48557390
31Regulation of autophagy_Homo sapiens_hsa041401.44160053
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.41705667
33Olfactory transduction_Homo sapiens_hsa047401.41255950
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39582233
35One carbon pool by folate_Homo sapiens_hsa006701.21803589
36Morphine addiction_Homo sapiens_hsa050321.12779207
37ABC transporters_Homo sapiens_hsa020101.11820011
38Steroid biosynthesis_Homo sapiens_hsa001001.08414860
39GABAergic synapse_Homo sapiens_hsa047271.07338139
40Parkinsons disease_Homo sapiens_hsa050121.06629392
41Peroxisome_Homo sapiens_hsa041461.05396251
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04619266
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.03348361
44Insulin secretion_Homo sapiens_hsa049111.02500497
45Chemical carcinogenesis_Homo sapiens_hsa052041.01963929
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01915838
47Huntingtons disease_Homo sapiens_hsa050160.98043571
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96018967
49Circadian entrainment_Homo sapiens_hsa047130.95233701
50Serotonergic synapse_Homo sapiens_hsa047260.94076181
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91984963
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89672032
53Glutamatergic synapse_Homo sapiens_hsa047240.87377489
54RNA transport_Homo sapiens_hsa030130.86350714
55Purine metabolism_Homo sapiens_hsa002300.83724068
56Salivary secretion_Homo sapiens_hsa049700.80490787
57Arachidonic acid metabolism_Homo sapiens_hsa005900.79409593
58Dopaminergic synapse_Homo sapiens_hsa047280.79073578
59Retinol metabolism_Homo sapiens_hsa008300.78663724
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78541980
61Circadian rhythm_Homo sapiens_hsa047100.77947780
62Nucleotide excision repair_Homo sapiens_hsa034200.77643678
63Cardiac muscle contraction_Homo sapiens_hsa042600.77175457
64beta-Alanine metabolism_Homo sapiens_hsa004100.73304908
65Mismatch repair_Homo sapiens_hsa034300.73184022
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71235682
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70328617
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.67982291
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67803493
70Sulfur metabolism_Homo sapiens_hsa009200.67354905
71Ovarian steroidogenesis_Homo sapiens_hsa049130.65599879
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64908146
73Metabolic pathways_Homo sapiens_hsa011000.63579000
74Dorso-ventral axis formation_Homo sapiens_hsa043200.63133528
75Calcium signaling pathway_Homo sapiens_hsa040200.63089003
76Long-term depression_Homo sapiens_hsa047300.58723935
77Fatty acid elongation_Homo sapiens_hsa000620.58222393
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56030299
79Alzheimers disease_Homo sapiens_hsa050100.56017202
80Pyrimidine metabolism_Homo sapiens_hsa002400.54734696
81Fatty acid biosynthesis_Homo sapiens_hsa000610.54470077
82Proteasome_Homo sapiens_hsa030500.53785173
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53596482
84Collecting duct acid secretion_Homo sapiens_hsa049660.53412869
85Fatty acid metabolism_Homo sapiens_hsa012120.53274122
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49759229
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.49192697
88Glycerolipid metabolism_Homo sapiens_hsa005610.48321399
89Amphetamine addiction_Homo sapiens_hsa050310.47155930
90Histidine metabolism_Homo sapiens_hsa003400.43822428
91Hedgehog signaling pathway_Homo sapiens_hsa043400.43612719
92Cocaine addiction_Homo sapiens_hsa050300.43422537
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42470657
94Oocyte meiosis_Homo sapiens_hsa041140.40512210
95Base excision repair_Homo sapiens_hsa034100.36490957
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.36352454
97Lysine degradation_Homo sapiens_hsa003100.35286467
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34485409
99Sphingolipid metabolism_Homo sapiens_hsa006000.31327626
100TGF-beta signaling pathway_Homo sapiens_hsa043500.30167214

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