PABPC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.80729251
2ribosomal small subunit assembly (GO:0000028)6.78500718
3viral transcription (GO:0019083)5.65959253
4translational termination (GO:0006415)5.47702543
5maturation of SSU-rRNA (GO:0030490)5.31938463
6ribosomal small subunit biogenesis (GO:0042274)5.18795171
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.10737491
8cytidine metabolic process (GO:0046087)4.93468837
9cytidine catabolic process (GO:0006216)4.93468837
10cytidine deamination (GO:0009972)4.93468837
11translational elongation (GO:0006414)4.74463332
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.71785088
13cotranslational protein targeting to membrane (GO:0006613)4.64355329
14protein targeting to ER (GO:0045047)4.63412433
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.63040418
16protein neddylation (GO:0045116)4.62971522
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54166238
18ATP synthesis coupled proton transport (GO:0015986)4.54166238
19protein localization to endoplasmic reticulum (GO:0070972)4.40500273
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.39742971
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37332258
22pyrimidine ribonucleoside catabolic process (GO:0046133)4.26000710
23ribosomal large subunit biogenesis (GO:0042273)4.23595663
24viral life cycle (GO:0019058)4.10797616
25cellular protein complex disassembly (GO:0043624)4.04432015
26translational initiation (GO:0006413)4.02798272
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.01478629
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00023301
29pseudouridine synthesis (GO:0001522)3.96530103
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.90978817
31tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.90978817
32chaperone-mediated protein transport (GO:0072321)3.76506836
33NADH dehydrogenase complex assembly (GO:0010257)3.61662627
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61662627
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.61662627
36translation (GO:0006412)3.61592671
37protein complex biogenesis (GO:0070271)3.51835535
38piRNA metabolic process (GO:0034587)3.46447076
39protein complex disassembly (GO:0043241)3.39744594
40respiratory electron transport chain (GO:0022904)3.39501345
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39053058
42electron transport chain (GO:0022900)3.38797433
43ribonucleoprotein complex biogenesis (GO:0022613)3.37875449
44synapsis (GO:0007129)3.36947948
45water-soluble vitamin biosynthetic process (GO:0042364)3.35764383
46behavioral response to nicotine (GO:0035095)3.33961356
47termination of RNA polymerase III transcription (GO:0006386)3.32422182
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.32422182
49exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31652376
50cellular component biogenesis (GO:0044085)3.25246873
51male meiosis I (GO:0007141)3.24528061
52macromolecular complex disassembly (GO:0032984)3.24455955
53negative regulation by host of viral transcription (GO:0043922)3.20461453
54mitochondrial respiratory chain complex assembly (GO:0033108)3.19485667
55rRNA processing (GO:0006364)3.11809918
56positive regulation of defense response to virus by host (GO:0002230)3.11626230
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.10368434
58rRNA metabolic process (GO:0016072)3.09938811
59rRNA modification (GO:0000154)2.99746602
60positive regulation of respiratory burst (GO:0060267)2.99066679
61mRNA catabolic process (GO:0006402)2.91031010
62protein polyglutamylation (GO:0018095)2.89917897
63negative regulation of telomere maintenance (GO:0032205)2.89495780
64protein targeting to membrane (GO:0006612)2.85396919
65response to pheromone (GO:0019236)2.83028286
66cornea development in camera-type eye (GO:0061303)2.82857186
67proteasome assembly (GO:0043248)2.78134984
68mannosylation (GO:0097502)2.77379657
69RNA catabolic process (GO:0006401)2.69335145
70platelet dense granule organization (GO:0060155)2.67058881
71protein-cofactor linkage (GO:0018065)2.66194220
72male meiosis (GO:0007140)2.65375449
73intracellular protein transmembrane import (GO:0044743)2.64321830
74tRNA processing (GO:0008033)2.64171726
75regulation of chronic inflammatory response (GO:0002676)2.61313700
76chromatin remodeling at centromere (GO:0031055)2.58758061
77meiosis I (GO:0007127)2.57748113
78GPI anchor metabolic process (GO:0006505)2.55822252
79negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55054796
80hydrogen ion transmembrane transport (GO:1902600)2.53926818
81ATP biosynthetic process (GO:0006754)2.49968011
82DNA methylation involved in gamete generation (GO:0043046)2.47193598
83ncRNA processing (GO:0034470)2.45914558
84ribosome biogenesis (GO:0042254)2.45889660
85DNA demethylation (GO:0080111)2.45599529
86rRNA methylation (GO:0031167)2.45490466
87purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.44062297
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.43912588
89establishment of protein localization to mitochondrion (GO:0072655)2.43223561
90rRNA catabolic process (GO:0016075)2.42909767
91GPI anchor biosynthetic process (GO:0006506)2.42347126
92somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.42317344
93somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.42317344
94isotype switching (GO:0045190)2.42317344
95protein targeting to mitochondrion (GO:0006626)2.42047084
96proton transport (GO:0015992)2.41314762
97regulation of cellular amino acid metabolic process (GO:0006521)2.40661928
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40004902
99preassembly of GPI anchor in ER membrane (GO:0016254)2.38196574
100CENP-A containing nucleosome assembly (GO:0034080)2.37464855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.03500347
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85581564
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.34133008
4VDR_22108803_ChIP-Seq_LS180_Human3.32134409
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09630495
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93764304
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66032354
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65137818
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65008471
10ZNF274_21170338_ChIP-Seq_K562_Hela2.58274493
11VDR_23849224_ChIP-Seq_CD4+_Human2.44226409
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40900619
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40155391
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37079106
15EZH2_22144423_ChIP-Seq_EOC_Human2.35093524
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.30411683
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.28374188
18MYC_18940864_ChIP-ChIP_HL60_Human2.26685076
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.12658498
20FOXP3_21729870_ChIP-Seq_TREG_Human2.04568982
21IGF1R_20145208_ChIP-Seq_DFB_Human1.92507549
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.91808041
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90061564
24FUS_26573619_Chip-Seq_HEK293_Human1.89181911
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84649369
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84241071
27EWS_26573619_Chip-Seq_HEK293_Human1.83164313
28ELK1_19687146_ChIP-ChIP_HELA_Human1.81803092
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81058814
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.66653479
31TP53_22573176_ChIP-Seq_HFKS_Human1.64912238
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62309852
33IRF1_19129219_ChIP-ChIP_H3396_Human1.58676023
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54470611
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52146333
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50544016
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48121378
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47372031
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.47372031
40TTF2_22483619_ChIP-Seq_HELA_Human1.47308531
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.47289315
42NANOG_20526341_ChIP-Seq_ESCs_Human1.40397160
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40191077
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37486470
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36947120
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36914881
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35934056
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35585686
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32873772
50GATA3_26560356_Chip-Seq_TH2_Human1.28031944
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27175785
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26851336
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24379868
54ER_23166858_ChIP-Seq_MCF-7_Human1.24014410
55AR_20517297_ChIP-Seq_VCAP_Human1.21718265
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.20193312
57NANOG_19829295_ChIP-Seq_ESCs_Human1.19285165
58SOX2_19829295_ChIP-Seq_ESCs_Human1.19285165
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19160923
60ERG_20517297_ChIP-Seq_VCAP_Human1.18251586
61HOXB7_26014856_ChIP-Seq_BT474_Human1.17305894
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15409373
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13937625
64P300_19829295_ChIP-Seq_ESCs_Human1.13516617
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11864103
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11658605
67* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10435058
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10411623
69NCOR_22424771_ChIP-Seq_293T_Human1.08562858
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07881962
71* ERA_21632823_ChIP-Seq_H3396_Human1.07692228
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06445173
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.06189694
74GABP_19822575_ChIP-Seq_HepG2_Human1.05396647
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04305787
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03528029
77TAF15_26573619_Chip-Seq_HEK293_Human1.03475549
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.03208319
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01358609
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01142256
81MYC_19829295_ChIP-Seq_ESCs_Human1.00875092
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00037818
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98920775
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98915267
85CBP_20019798_ChIP-Seq_JUKART_Human0.98915267
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97120037
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97054926
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95380530
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94856514
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94031725
91DCP1A_22483619_ChIP-Seq_HELA_Human0.93948084
92MYB_26560356_Chip-Seq_TH2_Human0.93355254
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92404839
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91277689
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91166414
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90706812
97XRN2_22483619_ChIP-Seq_HELA_Human0.90133498
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90059291
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89713041
100RNF2_27304074_Chip-Seq_NSC_Mouse0.88357592

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.08535263
2MP0009379_abnormal_foot_pigmentation4.64210160
3MP0008877_abnormal_DNA_methylation3.18966171
4MP0005671_abnormal_response_to2.99175589
5MP0004147_increased_porphyrin_level2.66079354
6MP0003646_muscle_fatigue2.38488231
7MP0001835_abnormal_antigen_presentation2.04795791
8MP0005646_abnormal_pituitary_gland2.04401335
9MP0002160_abnormal_reproductive_system1.90357632
10MP0008872_abnormal_physiological_respon1.86689926
11MP0001188_hyperpigmentation1.79604935
12MP0006072_abnormal_retinal_apoptosis1.75095059
13MP0002837_dystrophic_cardiac_calcinosis1.74946366
14MP0002638_abnormal_pupillary_reflex1.72925270
15MP0004885_abnormal_endolymph1.72655801
16MP0008058_abnormal_DNA_repair1.69677609
17MP0002163_abnormal_gland_morphology1.66223463
18MP0003787_abnormal_imprinting1.65657168
19MP0005084_abnormal_gallbladder_morpholo1.65077038
20MP0002138_abnormal_hepatobiliary_system1.64232963
21MP0001873_stomach_inflammation1.61502745
22MP0005389_reproductive_system_phenotype1.53190651
23MP0001293_anophthalmia1.52003887
24MP0008789_abnormal_olfactory_epithelium1.50045157
25MP0005410_abnormal_fertilization1.48522681
26MP0000685_abnormal_immune_system1.45515782
27MP0009333_abnormal_splenocyte_physiolog1.43894085
28MP0003878_abnormal_ear_physiology1.41345128
29MP0005377_hearing/vestibular/ear_phenot1.41345128
30MP0002148_abnormal_hypersensitivity_rea1.41001727
31MP0003567_abnormal_fetal_cardiomyocyte1.40120598
32MP0002876_abnormal_thyroid_physiology1.39585702
33MP0005551_abnormal_eye_electrophysiolog1.38582407
34MP0001800_abnormal_humoral_immune1.38572974
35MP0003786_premature_aging1.37313507
36MP0001485_abnormal_pinna_reflex1.32085943
37MP0002938_white_spotting1.30858428
38MP0008875_abnormal_xenobiotic_pharmacok1.30527929
39MP0005174_abnormal_tail_pigmentation1.30471943
40MP0003806_abnormal_nucleotide_metabolis1.30041386
41MP0004142_abnormal_muscle_tone1.29506734
42MP0001905_abnormal_dopamine_level1.29161164
43MP0009785_altered_susceptibility_to1.26658292
44MP0001968_abnormal_touch/_nociception1.26394649
45MP0000372_irregular_coat_pigmentation1.26373817
46MP0002736_abnormal_nociception_after1.24480767
47MP0003718_maternal_effect1.23839549
48MP0002277_abnormal_respiratory_mucosa1.20297216
49MP0002210_abnormal_sex_determination1.19888568
50MP0003693_abnormal_embryo_hatching1.16972044
51MP0000631_abnormal_neuroendocrine_gland1.15400076
52MP0005645_abnormal_hypothalamus_physiol1.15145431
53MP0008995_early_reproductive_senescence1.12048944
54MP0002095_abnormal_skin_pigmentation1.10047228
55MP0005075_abnormal_melanosome_morpholog1.09603548
56MP0005000_abnormal_immune_tolerance1.09227107
57MP0002102_abnormal_ear_morphology1.08697050
58MP0005387_immune_system_phenotype1.08376366
59MP0001790_abnormal_immune_system1.08376366
60MP0006276_abnormal_autonomic_nervous1.03757206
61MP0001919_abnormal_reproductive_system1.03649811
62MP0002723_abnormal_immune_serum1.03527565
63MP0004742_abnormal_vestibular_system0.99700050
64MP0001929_abnormal_gametogenesis0.98679132
65MP0002272_abnormal_nervous_system0.98054937
66MP0005253_abnormal_eye_physiology0.97505291
67MP0004145_abnormal_muscle_electrophysio0.97428591
68MP0003123_paternal_imprinting0.97412590
69MP0002653_abnormal_ependyma_morphology0.97332442
70MP0003195_calcinosis0.96397229
71MP0000049_abnormal_middle_ear0.95784080
72MP0009764_decreased_sensitivity_to0.95084500
73MP0003186_abnormal_redox_activity0.94421975
74MP0003136_yellow_coat_color0.92470949
75MP0002420_abnormal_adaptive_immunity0.92059832
76MP0001819_abnormal_immune_cell0.91571900
77MP0005499_abnormal_olfactory_system0.90731506
78MP0005394_taste/olfaction_phenotype0.90731506
79MP0001145_abnormal_male_reproductive0.90135397
80MP0004043_abnormal_pH_regulation0.89949041
81MP0001501_abnormal_sleep_pattern0.88451174
82MP0005379_endocrine/exocrine_gland_phen0.88388739
83MP0002234_abnormal_pharynx_morphology0.87703825
84MP0001529_abnormal_vocalization0.87627798
85MP0003698_abnormal_male_reproductive0.85481049
86MP0000653_abnormal_sex_gland0.84816431
87MP0003763_abnormal_thymus_physiology0.82667746
88MP0002398_abnormal_bone_marrow0.81598122
89MP0002452_abnormal_antigen_presenting0.80515857
90MP0002693_abnormal_pancreas_physiology0.78329420
91MP0000703_abnormal_thymus_morphology0.77971605
92MP0001764_abnormal_homeostasis0.77352097
93MP0002735_abnormal_chemical_nociception0.77157739
94MP0006036_abnormal_mitochondrial_physio0.75784030
95MP0009745_abnormal_behavioral_response0.75295748
96MP0000716_abnormal_immune_system0.75262917
97MP0002733_abnormal_thermal_nociception0.74856924
98MP0003638_abnormal_response/metabolism_0.72894590
99MP0000689_abnormal_spleen_morphology0.70945354
100MP0001119_abnormal_female_reproductive0.70742560

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.18453794
2Mitochondrial inheritance (HP:0001427)3.74691101
3Congenital stationary night blindness (HP:0007642)3.67662777
4Abnormal mitochondria in muscle tissue (HP:0008316)3.54554453
5Acute encephalopathy (HP:0006846)3.50603507
6Reticulocytopenia (HP:0001896)3.43671140
73-Methylglutaconic aciduria (HP:0003535)3.42413257
8Increased CSF lactate (HP:0002490)3.39865107
9Progressive macrocephaly (HP:0004481)3.38043379
10IgG deficiency (HP:0004315)3.37046538
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21953668
12Increased hepatocellular lipid droplets (HP:0006565)3.18933920
13Abnormality of cells of the erythroid lineage (HP:0012130)3.18643758
14Lipid accumulation in hepatocytes (HP:0006561)3.07140313
15Pancreatic cysts (HP:0001737)3.04730785
16Hepatocellular necrosis (HP:0001404)3.03351879
17Abnormal rod and cone electroretinograms (HP:0008323)2.92283256
18Abnormality of midbrain morphology (HP:0002418)2.88754415
19Molar tooth sign on MRI (HP:0002419)2.88754415
20Macrocytic anemia (HP:0001972)2.88726847
21Hepatic necrosis (HP:0002605)2.82924844
22Abnormal number of erythroid precursors (HP:0012131)2.78527427
23Pancreatic fibrosis (HP:0100732)2.75100716
24Renal Fanconi syndrome (HP:0001994)2.73277939
25Cerebral edema (HP:0002181)2.69423922
26Hyperglycinemia (HP:0002154)2.67046902
27Nephronophthisis (HP:0000090)2.64429973
28Microretrognathia (HP:0000308)2.63700233
29Stomatitis (HP:0010280)2.61350513
30Pallor (HP:0000980)2.60122402
31Aplastic anemia (HP:0001915)2.58309487
32Septo-optic dysplasia (HP:0100842)2.58046025
33True hermaphroditism (HP:0010459)2.55244057
34Congenital, generalized hypertrichosis (HP:0004540)2.46954289
35Optic disc pallor (HP:0000543)2.46356402
36Abolished electroretinogram (ERG) (HP:0000550)2.45077904
37Abnormality of the renal cortex (HP:0011035)2.39054756
38Increased IgM level (HP:0003496)2.39045708
39Exertional dyspnea (HP:0002875)2.36845219
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34184637
41Absent thumb (HP:0009777)2.29562057
42Increased serum lactate (HP:0002151)2.28419377
43Increased intramyocellular lipid droplets (HP:0012240)2.25922581
44Type II lissencephaly (HP:0007260)2.25528497
45Abnormality of the renal medulla (HP:0100957)2.25193995
46Aplasia/hypoplasia of the uterus (HP:0008684)2.22402319
47Optic nerve hypoplasia (HP:0000609)2.20655316
48Hypoplasia of the uterus (HP:0000013)2.18986595
49Decreased central vision (HP:0007663)2.18649873
50Pendular nystagmus (HP:0012043)2.18120382
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15716899
52Lactic acidosis (HP:0003128)2.10145873
53Reduced antithrombin III activity (HP:0001976)2.09740532
54Birth length less than 3rd percentile (HP:0003561)2.06143743
55Methylmalonic acidemia (HP:0002912)2.05485862
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05166102
57Severe combined immunodeficiency (HP:0004430)2.03803672
58Abnormality of DNA repair (HP:0003254)2.02833955
59Lethargy (HP:0001254)2.02328028
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00063251
61Abnormality of alanine metabolism (HP:0010916)2.00063251
62Hyperalaninemia (HP:0003348)2.00063251
63Elevated erythrocyte sedimentation rate (HP:0003565)1.98859973
64Hypoplasia of the pons (HP:0012110)1.98312425
65Abnormality of the pons (HP:0007361)1.96635703
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.96366946
67Medial flaring of the eyebrow (HP:0010747)1.95043400
68Respiratory difficulties (HP:0002880)1.94017119
69Renal cortical cysts (HP:0000803)1.93606698
70Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93012628
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93012628
72Asplenia (HP:0001746)1.89944587
73Attenuation of retinal blood vessels (HP:0007843)1.89205217
74Increased muscle lipid content (HP:0009058)1.89125884
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88469032
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87056559
77Stenosis of the external auditory canal (HP:0000402)1.86533835
78Abnormality of renal resorption (HP:0011038)1.85537232
79Diastasis recti (HP:0001540)1.85111985
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.84487980
81Hypoplasia of the fovea (HP:0007750)1.84487980
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.84121726
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83943784
84Pancytopenia (HP:0001876)1.83395145
85Glycosuria (HP:0003076)1.81425936
86Abnormality of urine glucose concentration (HP:0011016)1.81425936
87Type I transferrin isoform profile (HP:0003642)1.80512190
88Hypoproteinemia (HP:0003075)1.79949473
89Abnormality of B cell number (HP:0010975)1.79058582
90B lymphocytopenia (HP:0010976)1.75740658
91Type 2 muscle fiber atrophy (HP:0003554)1.75194491
92Male pseudohermaphroditism (HP:0000037)1.75104142
93Hypoplasia of the radius (HP:0002984)1.74420750
94Respiratory failure (HP:0002878)1.74375751
95Abnormal protein glycosylation (HP:0012346)1.74194637
96Abnormal glycosylation (HP:0012345)1.74194637
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74194637
98Abnormal protein N-linked glycosylation (HP:0012347)1.74194637
99Hyperglycinuria (HP:0003108)1.73566482
100Abnormality of glycine metabolism (HP:0010895)1.73281029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.69866131
2TXK3.43116744
3ZAK3.37909889
4MAP4K23.15197778
5TLK13.02521900
6STK162.40984052
7GRK12.40192925
8VRK22.37779415
9PINK12.37636170
10BCKDK2.29161818
11ADRBK22.17486633
12WNK42.13940538
13BMPR1B2.08127291
14ACVR1B2.03547371
15NUAK11.92624683
16CDK191.91344916
17KDR1.83028328
18MAP4K11.71508148
19TESK21.70814379
20DAPK21.58552635
21MST41.56832154
22VRK11.55532913
23TIE11.48504497
24BUB11.39302666
25ITK1.36292837
26PASK1.29421242
27CDC71.25768362
28FRK1.19421188
29TEC1.16101662
30PRKCQ1.14942560
31IKBKB1.10834825
32PIK3CA1.03475441
33KIT1.01841011
34TGFBR11.01525167
35NME11.01490532
36RPS6KA50.96998059
37MKNK10.96105615
38WNK30.93830096
39MAPK130.93795413
40MAP3K120.93131633
41OXSR10.91840248
42MKNK20.90470847
43GRK60.88822386
44CDK30.86104044
45INSRR0.84265282
46EIF2AK30.83661974
47NLK0.83225078
48DYRK20.82505574
49SYK0.80007470
50PLK40.79064508
51STK390.75969652
52PHKG10.71851397
53PHKG20.71851397
54TAF10.71753807
55MATK0.70792584
56NEK20.69121394
57SRPK10.67231526
58BTK0.66872364
59MAP2K60.63454529
60MAP2K20.63076700
61ADRBK10.62142807
62CSNK1G10.61186102
63PDK20.60955750
64CAMKK10.58797630
65CSNK2A20.58256866
66CAMK10.55505517
67CSF1R0.54370811
68PLK30.53973378
69STK30.53537871
70STK38L0.53259639
71LCK0.52561295
72TNIK0.51753329
73LYN0.51165869
74MARK30.50531334
75PLK10.48889332
76RPS6KA60.48696141
77WNK10.47875455
78PIM10.47575859
79IKBKE0.46973647
80CSNK1A10.46871131
81FES0.46460783
82CSNK2A10.46410910
83PTK2B0.45657955
84CAMKK20.45220742
85FLT30.44597073
86DAPK10.42751693
87TNK20.42534889
88TRIM280.42302553
89AURKB0.40511580
90PRKCG0.39945065
91ALK0.38236706
92NME20.36609081
93CSNK1G30.35893652
94PRKACA0.35733889
95ATR0.35355732
96IGF1R0.33771322
97TRPM70.32793688
98AURKA0.32088525
99MAPK70.31192842
100MYLK0.30678357

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.17835796
2Oxidative phosphorylation_Homo sapiens_hsa001903.57045738
3Proteasome_Homo sapiens_hsa030503.33836016
4Parkinsons disease_Homo sapiens_hsa050122.98007623
5Primary immunodeficiency_Homo sapiens_hsa053402.65355747
6RNA polymerase_Homo sapiens_hsa030202.62188951
7Allograft rejection_Homo sapiens_hsa053302.29504774
8Asthma_Homo sapiens_hsa053102.13098754
9Huntingtons disease_Homo sapiens_hsa050162.11756060
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11046307
11Autoimmune thyroid disease_Homo sapiens_hsa053202.10182607
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.98258696
13Homologous recombination_Homo sapiens_hsa034401.96636178
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92001255
15Alzheimers disease_Homo sapiens_hsa050101.90496218
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85078156
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84144174
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83160900
19Graft-versus-host disease_Homo sapiens_hsa053321.81907323
20Protein export_Homo sapiens_hsa030601.78977616
21Type I diabetes mellitus_Homo sapiens_hsa049401.74815169
22Cardiac muscle contraction_Homo sapiens_hsa042601.72127359
23Linoleic acid metabolism_Homo sapiens_hsa005911.69505344
24Phototransduction_Homo sapiens_hsa047441.65988878
25Basal transcription factors_Homo sapiens_hsa030221.58903045
26One carbon pool by folate_Homo sapiens_hsa006701.58552135
27Nucleotide excision repair_Homo sapiens_hsa034201.53623576
28* RNA degradation_Homo sapiens_hsa030181.48474824
29DNA replication_Homo sapiens_hsa030301.35947509
30Mismatch repair_Homo sapiens_hsa034301.33457595
31Pyrimidine metabolism_Homo sapiens_hsa002401.30103997
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29458750
33Nitrogen metabolism_Homo sapiens_hsa009101.25857074
34Fanconi anemia pathway_Homo sapiens_hsa034601.22000247
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.21717238
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11484126
37Antigen processing and presentation_Homo sapiens_hsa046121.09959449
38Spliceosome_Homo sapiens_hsa030401.08109022
39Hematopoietic cell lineage_Homo sapiens_hsa046401.05072963
40* RNA transport_Homo sapiens_hsa030131.04819538
41Propanoate metabolism_Homo sapiens_hsa006401.04092176
42Caffeine metabolism_Homo sapiens_hsa002321.03617045
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01843781
44Base excision repair_Homo sapiens_hsa034100.97990659
45Purine metabolism_Homo sapiens_hsa002300.97530219
46Butanoate metabolism_Homo sapiens_hsa006500.93601978
47Rheumatoid arthritis_Homo sapiens_hsa053230.90438367
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87182876
49Peroxisome_Homo sapiens_hsa041460.85478012
50Retinol metabolism_Homo sapiens_hsa008300.85089501
51T cell receptor signaling pathway_Homo sapiens_hsa046600.83636380
52Arachidonic acid metabolism_Homo sapiens_hsa005900.81083009
53Chemical carcinogenesis_Homo sapiens_hsa052040.81002746
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.78623919
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74691361
56Tryptophan metabolism_Homo sapiens_hsa003800.73156142
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72549412
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72403984
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69433100
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.68724941
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67814831
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66183794
63Ether lipid metabolism_Homo sapiens_hsa005650.65496466
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64642063
65Olfactory transduction_Homo sapiens_hsa047400.63524176
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62135732
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.61992016
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60583092
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59904047
70Nicotine addiction_Homo sapiens_hsa050330.58609962
71Selenocompound metabolism_Homo sapiens_hsa004500.58406821
72Metabolic pathways_Homo sapiens_hsa011000.58353259
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57358253
74Systemic lupus erythematosus_Homo sapiens_hsa053220.56029403
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.55384595
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51994546
77Sulfur relay system_Homo sapiens_hsa041220.51684361
78Non-homologous end-joining_Homo sapiens_hsa034500.51464282
79Fat digestion and absorption_Homo sapiens_hsa049750.49966818
80Collecting duct acid secretion_Homo sapiens_hsa049660.46034579
81Regulation of autophagy_Homo sapiens_hsa041400.41978062
82Sulfur metabolism_Homo sapiens_hsa009200.41096156
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.39561734
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38513438
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36635320
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35222764
87Taste transduction_Homo sapiens_hsa047420.32147950
88Measles_Homo sapiens_hsa051620.30847355
89Epstein-Barr virus infection_Homo sapiens_hsa051690.28724612
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28119411
91Mineral absorption_Homo sapiens_hsa049780.27636016
92Serotonergic synapse_Homo sapiens_hsa047260.25536044
93Salivary secretion_Homo sapiens_hsa049700.23973445
94ABC transporters_Homo sapiens_hsa020100.23722727
95Viral myocarditis_Homo sapiens_hsa054160.23700071
96Tyrosine metabolism_Homo sapiens_hsa003500.23415123
97Vitamin digestion and absorption_Homo sapiens_hsa049770.22970970
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22496001
99Herpes simplex infection_Homo sapiens_hsa051680.20653233
100Malaria_Homo sapiens_hsa051440.18438836

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