P4HB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.29212489
2COPI coating of Golgi vesicle (GO:0048205)6.29212489
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.88378195
4protein retention in ER lumen (GO:0006621)5.40552603
5proline biosynthetic process (GO:0006561)5.22684118
6COPII vesicle coating (GO:0048208)4.74235010
7sulfur amino acid catabolic process (GO:0000098)4.47461369
8intestinal cholesterol absorption (GO:0030299)4.37961810
9desmosome organization (GO:0002934)4.17825245
10proline metabolic process (GO:0006560)4.14236323
11activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.05078649
12skin morphogenesis (GO:0043589)4.03658668
13regulation of plasminogen activation (GO:0010755)4.01193704
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98328108
15L-phenylalanine metabolic process (GO:0006558)3.98328108
16positive regulation of nuclease activity (GO:0032075)3.92638511
17basement membrane organization (GO:0071711)3.91844434
18L-phenylalanine catabolic process (GO:0006559)3.81188312
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.81188312
20protein localization to endosome (GO:0036010)3.75108813
21peptidyl-glutamic acid carboxylation (GO:0017187)3.72097495
22protein carboxylation (GO:0018214)3.72097495
23cell adhesion mediated by integrin (GO:0033627)3.61832001
24regulation of cholesterol homeostasis (GO:2000188)3.60318388
25negative regulation of fibrinolysis (GO:0051918)3.58045393
26endoplasmic reticulum unfolded protein response (GO:0030968)3.57915831
27regulation of nuclease activity (GO:0032069)3.55788163
28* 4-hydroxyproline metabolic process (GO:0019471)3.55716895
29hemidesmosome assembly (GO:0031581)3.53604355
30pinocytosis (GO:0006907)3.52944730
31glyoxylate metabolic process (GO:0046487)3.52296584
32intestinal absorption (GO:0050892)3.51306572
33cellular response to unfolded protein (GO:0034620)3.43779412
34alpha-linolenic acid metabolic process (GO:0036109)3.42469876
35triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.38922720
36cysteine metabolic process (GO:0006534)3.36173142
37ER-nucleus signaling pathway (GO:0006984)3.30296250
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.29992817
39cell-substrate junction assembly (GO:0007044)3.26813567
40barbed-end actin filament capping (GO:0051016)3.26575888
41positive regulation of extracellular matrix organization (GO:1903055)3.25818394
42cellular response to topologically incorrect protein (GO:0035967)3.24449630
43high-density lipoprotein particle remodeling (GO:0034375)3.20212465
44glutamine family amino acid biosynthetic process (GO:0009084)3.12619407
45ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.08701111
46aromatic amino acid family catabolic process (GO:0009074)3.07912229
47lysine catabolic process (GO:0006554)3.07231885
48lysine metabolic process (GO:0006553)3.07231885
49apoptotic cell clearance (GO:0043277)3.07211766
50reverse cholesterol transport (GO:0043691)3.04253087
51homocysteine metabolic process (GO:0050667)3.03457255
52regulation of fibrinolysis (GO:0051917)3.03423952
53negative regulation of fatty acid transport (GO:2000192)3.03102656
54negative regulation of fatty acid biosynthetic process (GO:0045717)3.03101886
55endodermal cell differentiation (GO:0035987)3.01633718
56glucose 6-phosphate metabolic process (GO:0051156)2.99291851
57regulation of early endosome to late endosome transport (GO:2000641)2.98799431
58urea cycle (GO:0000050)2.96483568
59urea metabolic process (GO:0019627)2.96483568
60triglyceride homeostasis (GO:0070328)2.95205732
61acylglycerol homeostasis (GO:0055090)2.95205732
62regulation of protein activation cascade (GO:2000257)2.95113513
63regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.94981582
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.94750638
65negative regulation of cell size (GO:0045792)2.94204861
66establishment of apical/basal cell polarity (GO:0035089)2.92831848
67focal adhesion assembly (GO:0048041)2.92772862
68cell-substrate adherens junction assembly (GO:0007045)2.92772862
69UDP-N-acetylglucosamine metabolic process (GO:0006047)2.91584188
70folic acid-containing compound biosynthetic process (GO:0009396)2.91012303
71hyaluronan catabolic process (GO:0030214)2.90028543
72vesicle coating (GO:0006901)2.89987476
73adherens junction assembly (GO:0034333)2.88849782
74mannose metabolic process (GO:0006013)2.86995893
75regulation of extracellular matrix disassembly (GO:0010715)2.86030630
76plasma lipoprotein particle assembly (GO:0034377)2.85263595
77cellular modified amino acid catabolic process (GO:0042219)2.85006773
78negative regulation of cholesterol transport (GO:0032375)2.84749520
79negative regulation of sterol transport (GO:0032372)2.84749520
80adhesion of symbiont to host (GO:0044406)2.84463226
81regulation of translational fidelity (GO:0006450)2.84372303
82regulation of complement activation (GO:0030449)2.82759806
83epithelial cell-cell adhesion (GO:0090136)2.82568503
84* response to endoplasmic reticulum stress (GO:0034976)2.82356120
85complement activation, alternative pathway (GO:0006957)2.79467984
86protein-lipid complex assembly (GO:0065005)2.79157915
87serine family amino acid biosynthetic process (GO:0009070)2.78874654
88low-density lipoprotein particle clearance (GO:0034383)2.78479504
89plasma lipoprotein particle clearance (GO:0034381)2.78441162
90maternal placenta development (GO:0001893)2.77133912
91glycine metabolic process (GO:0006544)2.77011352
92regulation of cholesterol biosynthetic process (GO:0045540)2.75681915
93kynurenine metabolic process (GO:0070189)2.75654296
94valine metabolic process (GO:0006573)2.75584701
95plasma lipoprotein particle remodeling (GO:0034369)2.74906745
96protein-lipid complex remodeling (GO:0034368)2.74906745
97macromolecular complex remodeling (GO:0034367)2.74906745
98exocrine pancreas development (GO:0031017)2.74640951
99cholesterol efflux (GO:0033344)2.73384608
100branching involved in mammary gland duct morphogenesis (GO:0060444)2.72484283
101glycosphingolipid catabolic process (GO:0046479)2.72456892
102peptide catabolic process (GO:0043171)2.72389675
103very-low-density lipoprotein particle assembly (GO:0034379)2.71974097
104serine family amino acid catabolic process (GO:0009071)2.71943700
105sequestering of metal ion (GO:0051238)2.71888971
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.70196959
107hormone catabolic process (GO:0042447)2.68525373
108nitrogen cycle metabolic process (GO:0071941)2.66455524
109membrane protein ectodomain proteolysis (GO:0006509)2.66373728
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66163754
111serine family amino acid metabolic process (GO:0009069)2.64392655
112protein N-linked glycosylation via asparagine (GO:0018279)2.64023363
113peptidyl-asparagine modification (GO:0018196)2.63951283
114* lipoprotein metabolic process (GO:0042157)2.63807446
115bile acid biosynthetic process (GO:0006699)2.63440794
116cholesterol homeostasis (GO:0042632)2.61192918
117sterol homeostasis (GO:0055092)2.60590378
118embryonic process involved in female pregnancy (GO:0060136)2.60359341
119bile acid metabolic process (GO:0008206)2.60156444
120regulation of triglyceride catabolic process (GO:0010896)2.59912604
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58831167
122response to unfolded protein (GO:0006986)2.58787557
123glucose catabolic process (GO:0006007)2.58499171
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57151206
125epoxygenase P450 pathway (GO:0019373)2.55122427
126regulation of extracellular matrix organization (GO:1903053)2.54388553
127regulation of apoptotic cell clearance (GO:2000425)2.53852558
128glycolipid catabolic process (GO:0019377)2.53599714
129L-alpha-amino acid transmembrane transport (GO:1902475)2.53520021
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.52487293
131protein maturation by protein folding (GO:0022417)2.52001494
132tryptophan metabolic process (GO:0006568)2.50389164
133response to topologically incorrect protein (GO:0035966)2.50239040
134pentose-phosphate shunt (GO:0006098)2.49846156
135GDP-mannose metabolic process (GO:0019673)2.49311415
136positive regulation of fatty acid beta-oxidation (GO:0032000)2.49292412
137phospholipid efflux (GO:0033700)2.48911331
138tetrahydrofolate metabolic process (GO:0046653)2.47936851
139stress fiber assembly (GO:0043149)2.46909411
140tyrosine metabolic process (GO:0006570)2.46668427
141activation of Rac GTPase activity (GO:0032863)2.46311063
142fibrinolysis (GO:0042730)2.44772417
143regulation of cholesterol esterification (GO:0010872)2.44207471
144protein N-linked glycosylation (GO:0006487)2.44109577
145positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43338322
146semaphorin-plexin signaling pathway (GO:0071526)2.42740507
147hyaluronan metabolic process (GO:0030212)2.41417836
148embryo implantation (GO:0007566)2.41309699
149positive regulation of endothelial cell apoptotic process (GO:2000353)2.39530981
150NADH metabolic process (GO:0006734)2.39235808
151NADPH regeneration (GO:0006740)2.38925769
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.38340122
153nucleotide-sugar biosynthetic process (GO:0009226)2.37005209
154dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.36488455
155extracellular matrix disassembly (GO:0022617)2.32763419
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31498687
157positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29787299
158negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29118215
159hypotonic response (GO:0006971)2.28506872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.56187221
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.22789787
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.88813983
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.24393562
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.08905420
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.05356381
7CLOCK_20551151_ChIP-Seq_293T_Human2.83947852
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51679275
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.40133390
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32398632
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28931879
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.25801663
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22913417
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.08710947
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08572370
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07733321
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05027098
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.01587038
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00017257
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98387793
21* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90375132
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.80962131
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68119133
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.67748402
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58657121
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56106444
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55792582
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53336131
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52805563
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51163583
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46856564
32RACK7_27058665_Chip-Seq_MCF-7_Human1.46320922
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46275681
34ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44632736
35ATF3_27146783_Chip-Seq_COLON_Human1.44059227
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.43979561
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43863064
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43359744
39AR_21909140_ChIP-Seq_LNCAP_Human1.43317496
40ZNF263_19887448_ChIP-Seq_K562_Human1.41236995
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.40471993
42* LXR_22292898_ChIP-Seq_THP-1_Human1.39971011
43MYC_22102868_ChIP-Seq_BL_Human1.39001434
44TCF7_22412390_ChIP-Seq_EML_Mouse1.38718962
45TP53_22127205_ChIP-Seq_IMR90_Human1.38345381
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36436288
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.35084198
48E2F7_22180533_ChIP-Seq_HELA_Human1.34452862
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33533864
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31538773
51GATA6_25053715_ChIP-Seq_YYC3_Human1.31064010
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30839993
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29986298
54* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29748247
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29273322
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.28372068
57* VDR_21846776_ChIP-Seq_THP-1_Human1.26754931
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26374055
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25893371
60KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24805669
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.24480275
62KDM2B_26808549_Chip-Seq_K562_Human1.24385981
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23448932
64GATA4_25053715_ChIP-Seq_YYC3_Human1.22385231
65TFEB_21752829_ChIP-Seq_HELA_Human1.21772094
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21452312
67* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17868509
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17774884
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17704942
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17173854
71KDM2B_26808549_Chip-Seq_DND41_Human1.15805214
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.15488733
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14851094
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14680275
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13926394
76SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13821562
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13746194
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13615346
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12823154
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11034085
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.10690952
82* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10400651
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09894500
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09349269
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09349269
86CHD1_26751641_Chip-Seq_LNCaP_Human1.08790014
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08311046
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07638496
89KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05743256
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05064698
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04928824
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.04049438
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03547263
94* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03502178
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.02510721
96P68_20966046_ChIP-Seq_HELA_Human1.02479132
97* VDR_24763502_ChIP-Seq_THP-1_Human1.02117376
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01379249
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01301629
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01239998
101SMC4_20622854_ChIP-Seq_HELA_Human1.00652009
102CREB1_26743006_Chip-Seq_LNCaP_Human1.00015601
103GATA1_22025678_ChIP-Seq_K562_Human1.00002691
104* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99752819
105SA1_27219007_Chip-Seq_ERYTHROID_Human0.99408385
106* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98979374
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98874495
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97818770
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97566627
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96514318
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96194289
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95993538
113NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95919618
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95795472
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95015223
116CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92932429
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91652584
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91539734
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90910171
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90910171
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90910171
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90706571
123SOX2_20726797_ChIP-Seq_SW620_Human0.90662455
124* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88545979
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.88337171
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87873913
127* NCOR1_26117541_ChIP-Seq_K562_Human0.87082923
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85137143
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84845799
130RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83913564
131* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83414205
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83303740
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.82858835
134* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82577178
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82572766
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.82536874
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.81532077
138* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81482648
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81327658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.03933453
2MP0005360_urolithiasis3.79396362
3MP0008438_abnormal_cutaneous_collagen3.66262086
4MP0003705_abnormal_hypodermis_morpholog3.48518813
5MP0005365_abnormal_bile_salt3.43765217
6MP0005085_abnormal_gallbladder_physiolo3.11066752
7MP0005451_abnormal_body_composition2.71980453
8MP0003252_abnormal_bile_duct2.38248843
9MP0001666_abnormal_nutrient_absorption2.32036777
10MP0003283_abnormal_digestive_organ2.26694405
11MP0003806_abnormal_nucleotide_metabolis2.22854060
12MP0009840_abnormal_foam_cell2.22240013
13MP0006054_spinal_hemorrhage2.09791500
14MP0005275_abnormal_skin_tensile2.05089944
15MP0008875_abnormal_xenobiotic_pharmacok1.97250914
16MP0004858_abnormal_nervous_system1.96067813
17MP0005083_abnormal_biliary_tract1.93869415
18MP0002877_abnormal_melanocyte_morpholog1.93353294
19MP0010352_gastrointestinal_tract_polyps1.91252444
20MP0004264_abnormal_extraembryonic_tissu1.86754776
21MP0005220_abnormal_exocrine_pancreas1.85761666
22MP0010329_abnormal_lipoprotein_level1.77659207
23MP0003566_abnormal_cell_adhesion1.68844602
24MP0005409_darkened_coat_color1.66578938
25MP0010234_abnormal_vibrissa_follicle1.65672097
26MP0004272_abnormal_basement_membrane1.63333514
27MP0003195_calcinosis1.63279037
28MP0005058_abnormal_lysosome_morphology1.55148008
29MP0003300_gastrointestinal_ulcer1.52298784
30MP0005623_abnormal_meninges_morphology1.46662964
31MP0009053_abnormal_anal_canal1.46129198
32MP0005023_abnormal_wound_healing1.44532371
33MP0005503_abnormal_tendon_morphology1.41578624
34MP0002060_abnormal_skin_morphology1.40131802
35MP0005332_abnormal_amino_acid1.36964051
36MP0008260_abnormal_autophagy1.36442460
37MP0000858_altered_metastatic_potential1.35578685
38MP0009384_cardiac_valve_regurgitation1.34650780
39MP0003950_abnormal_plasma_membrane1.32415352
40MP0000609_abnormal_liver_physiology1.31448469
41MP0005076_abnormal_cell_differentiation1.29860544
42MP0010030_abnormal_orbit_morphology1.28379503
43MP0003191_abnormal_cellular_cholesterol1.28201852
44MP0003941_abnormal_skin_development1.21932720
45MP0009643_abnormal_urine_homeostasis1.20191193
46MP0004019_abnormal_vitamin_homeostasis1.18368685
47MP0005501_abnormal_skin_physiology1.18324474
48MP0001661_extended_life_span1.17935174
49MP0004782_abnormal_surfactant_physiolog1.17529594
50MP0002896_abnormal_bone_mineralization1.17155140
51MP0000462_abnormal_digestive_system1.15969503
52MP0000678_abnormal_parathyroid_gland1.15257598
53MP0005319_abnormal_enzyme/_coenzyme1.08289982
54MP0000767_abnormal_smooth_muscle1.07290083
55MP0003279_aneurysm1.06578143
56MP0002118_abnormal_lipid_homeostasis1.05173420
57MP0000598_abnormal_liver_morphology1.03196449
58MP0001216_abnormal_epidermal_layer1.01348064
59MP0003868_abnormal_feces_composition0.99484055
60MP0001944_abnormal_pancreas_morphology0.97608503
61MP0001958_emphysema0.95565741
62MP0000537_abnormal_urethra_morphology0.94067039
63MP0000467_abnormal_esophagus_morphology0.93943492
64MP0000762_abnormal_tongue_morphology0.93674990
65MP0003329_amyloid_beta_deposits0.92291316
66MP0000534_abnormal_ureter_morphology0.91270043
67MP0003453_abnormal_keratinocyte_physiol0.90217856
68MP0005508_abnormal_skeleton_morphology0.90184707
69MP0000733_abnormal_muscle_development0.90115271
70MP0002282_abnormal_trachea_morphology0.88744143
71MP0009278_abnormal_bone_marrow0.88538137
72MP0004197_abnormal_fetal_growth/weight/0.88341415
73MP0003183_abnormal_peptide_metabolism0.88122237
74MP0005375_adipose_tissue_phenotype0.87862783
75MP0009780_abnormal_chondrocyte_physiolo0.87177780
76MP0002138_abnormal_hepatobiliary_system0.86594838
77MP0005666_abnormal_adipose_tissue0.83318922
78MP0001243_abnormal_dermal_layer0.82739760
79MP0005164_abnormal_response_to0.82465390
80MP0005408_hypopigmentation0.82365568
81MP0000751_myopathy0.82247010
82MP0004947_skin_inflammation0.81915742
83MP0002086_abnormal_extraembryonic_tissu0.81006099
84MP0001348_abnormal_lacrimal_gland0.80741421
85MP0005621_abnormal_cell_physiology0.80215752
86MP0010307_abnormal_tumor_latency0.79554709
87MP0005165_increased_susceptibility_to0.77661796
88MP0009931_abnormal_skin_appearance0.76920974
89MP0003172_abnormal_lysosome_physiology0.75658210
90MP0003119_abnormal_digestive_system0.75355874
91MP0001915_intracranial_hemorrhage0.75047936
92MP0000013_abnormal_adipose_tissue0.74787266
93MP0002295_abnormal_pulmonary_circulatio0.74722914
94MP0005197_abnormal_uvea_morphology0.74326815
95MP0000627_abnormal_mammary_gland0.74138365
96MP0000604_amyloidosis0.73340336
97MP0000747_muscle_weakness0.72753305
98MP0000163_abnormal_cartilage_morphology0.71803890
99MP0001881_abnormal_mammary_gland0.70830405
100MP0002098_abnormal_vibrissa_morphology0.70700857
101MP0003186_abnormal_redox_activity0.70612912
102MP0001756_abnormal_urination0.70608794
103MP0002998_abnormal_bone_remodeling0.68977033
104MP0002111_abnormal_tail_morphology0.68267099
105MP0002796_impaired_skin_barrier0.68243284
106MP0002928_abnormal_bile_duct0.67786341
107MP0001849_ear_inflammation0.67682240
108MP0003942_abnormal_urinary_system0.66927202
109MP0000371_diluted_coat_color0.65778017
110MP0000477_abnormal_intestine_morphology0.65704459
111MP0003436_decreased_susceptibility_to0.64982966
112MP0003115_abnormal_respiratory_system0.64616168
113MP0000003_abnormal_adipose_tissue0.64269471
114MP0005257_abnormal_intraocular_pressure0.64169913
115MP0010771_integument_phenotype0.63804684
116MP0010368_abnormal_lymphatic_system0.63433903
117MP0002168_other_aberrant_phenotype0.62662653
118MP0002078_abnormal_glucose_homeostasis0.62537190
119MP0005084_abnormal_gallbladder_morpholo0.62256672
120MP0001542_abnormal_bone_strength0.62242137
121MP0005330_cardiomyopathy0.62228795
122MP0002115_abnormal_skeleton_extremities0.62085321
123MP0003091_abnormal_cell_migration0.62013196
124MP0004233_abnormal_muscle_weight0.61953522
125MP0000681_abnormal_thyroid_gland0.61769393
126MP0001614_abnormal_blood_vessel0.60818357
127MP0000639_abnormal_adrenal_gland0.60305812
128MP0004185_abnormal_adipocyte_glucose0.59944680
129MP0005464_abnormal_platelet_physiology0.59573543
130MP0003075_altered_response_to0.59500362
131MP0002693_abnormal_pancreas_physiology0.59179188
132MP0001730_embryonic_growth_arrest0.58886373
133MP0004957_abnormal_blastocyst_morpholog0.58664084
134MP0005670_abnormal_white_adipose0.58391693
135MP0000490_abnormal_crypts_of0.57209528
136MP0001764_abnormal_homeostasis0.56769862
137MP0005390_skeleton_phenotype0.56386827
138MP0002084_abnormal_developmental_patter0.56308306
139MP0005248_abnormal_Harderian_gland0.55449184
140MP0001697_abnormal_embryo_size0.55158413
141MP0003795_abnormal_bone_structure0.55081987
142MP0002089_abnormal_postnatal_growth/wei0.54886065
143MP0002135_abnormal_kidney_morphology0.54848534
144MP0003890_abnormal_embryonic-extraembry0.54710674
145MP0002088_abnormal_embryonic_growth/wei0.53794560
146MP0003984_embryonic_growth_retardation0.53568086
147MP0002269_muscular_atrophy0.52820627

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.16073799
2Deep venous thrombosis (HP:0002625)3.85416106
3Intrahepatic cholestasis (HP:0001406)3.81795611
4Premature rupture of membranes (HP:0001788)3.77145956
5Hypoglycemic coma (HP:0001325)3.75873887
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.66160060
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.60480119
8Hypobetalipoproteinemia (HP:0003563)3.56027701
9Xanthomatosis (HP:0000991)3.49336903
10Abnormality of the intrinsic pathway (HP:0010989)3.41265475
11Abnormality of the common coagulation pathway (HP:0010990)3.21800526
12Cerebral aneurysm (HP:0004944)3.16799754
13Mucopolysacchariduria (HP:0008155)3.12680227
14Urinary glycosaminoglycan excretion (HP:0003541)3.12680227
15Cervical subluxation (HP:0003308)3.06712495
16Hypoglycemic seizures (HP:0002173)2.96869111
17Abnormality of carpal bone ossification (HP:0006257)2.85089071
18Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79419902
19Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79419902
20Abnormality of polysaccharide metabolism (HP:0011012)2.79419902
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.78509570
22Abnormality of the Achilles tendon (HP:0005109)2.73798054
23Ulnar bowing (HP:0003031)2.73006292
24Achilles tendon contracture (HP:0001771)2.70114640
25Ketoacidosis (HP:0001993)2.66678363
26Fragile skin (HP:0001030)2.65707866
27Hypolipoproteinemia (HP:0010981)2.64666017
28Vascular tortuosity (HP:0004948)2.64661506
29Arterial tortuosity (HP:0005116)2.64490949
30Peritonitis (HP:0002586)2.63245183
31Abnormality of the pancreatic islet cells (HP:0006476)2.61588005
32Abnormality of endocrine pancreas physiology (HP:0012093)2.61588005
33Fat malabsorption (HP:0002630)2.61568191
34Hyperinsulinemic hypoglycemia (HP:0000825)2.61402855
35Dysostosis multiplex (HP:0000943)2.60593292
36Turricephaly (HP:0000262)2.58108072
37Ketosis (HP:0001946)2.55113631
38Biconcave vertebral bodies (HP:0004586)2.54349411
39Abnormal ossification of hand bones (HP:0005921)2.50879738
40Pancreatic islet-cell hyperplasia (HP:0004510)2.47269171
41Abnormality of dentin (HP:0010299)2.43147227
42Hyperacusis (HP:0010780)2.41587242
43Spinal rigidity (HP:0003306)2.37166605
44Prolonged partial thromboplastin time (HP:0003645)2.35813626
45Myocardial infarction (HP:0001658)2.35790397
46Blue sclerae (HP:0000592)2.35343815
47Ankle contracture (HP:0006466)2.33758288
48Short nail (HP:0001799)2.33699853
49Back pain (HP:0003418)2.31460848
50Alopecia of scalp (HP:0002293)2.28950617
51Distal upper limb amyotrophy (HP:0007149)2.28102655
52Upper limb amyotrophy (HP:0009129)2.28102655
53Complement deficiency (HP:0004431)2.28005116
54Hemorrhage of the eye (HP:0011885)2.27750492
55Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25946271
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.25862471
57Metaphyseal cupping (HP:0003021)2.25779180
58Elbow flexion contracture (HP:0002987)2.25727644
59Abnormal cartilage morphology (HP:0002763)2.25723452
60Symptomatic seizures (HP:0011145)2.25691306
61Aneurysm (HP:0002617)2.25616716
62Disproportionate tall stature (HP:0001519)2.25278008
63Aortic dissection (HP:0002647)2.23983379
64Late onset (HP:0003584)2.23108684
65Aortic aneurysm (HP:0004942)2.22995486
66Mitral stenosis (HP:0001718)2.20022703
67Hyperglycemia (HP:0003074)2.19890481
68Hydroxyprolinuria (HP:0003080)2.19215125
69Abnormality of proline metabolism (HP:0010907)2.19215125
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.17292452
71Osteolytic defects of the hand bones (HP:0009699)2.17292452
72Broad face (HP:0000283)2.14749820
73Abnormality of the distal phalanges of the toes (HP:0010182)2.14246784
74Asymmetry of the thorax (HP:0001555)2.13897686
75Abnormal delivery (HP:0001787)2.11885422
76Hypoalphalipoproteinemia (HP:0003233)2.10336629
77Abnormal foot bone ossification (HP:0010675)2.07504063
78Increased connective tissue (HP:0009025)2.07480930
79Hyperammonemia (HP:0001987)2.07333074
80Mildly elevated creatine phosphokinase (HP:0008180)2.06953250
81Distal lower limb amyotrophy (HP:0008944)2.05001589
82Coxa vara (HP:0002812)2.04510192
83Abnormal tarsal ossification (HP:0008369)2.04482497
84Spastic diplegia (HP:0001264)2.04410658
85Atrophic scars (HP:0001075)2.04137649
86Cardiovascular calcification (HP:0011915)2.02101304
87Skin nodule (HP:0200036)2.01842437
88Beaking of vertebral bodies (HP:0004568)2.00997753
89Thoracolumbar scoliosis (HP:0002944)2.00940095
90Abnormality of complement system (HP:0005339)2.00342055
91Abnormal enzyme/coenzyme activity (HP:0012379)2.00165572
92Abdominal distention (HP:0003270)1.99608675
93Nonimmune hydrops fetalis (HP:0001790)1.98871912
94Abnormal hand bone ossification (HP:0010660)1.98339587
95Joint stiffness (HP:0001387)1.98329526
96Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.98275289
97Vertebral hypoplasia (HP:0008417)1.98275289
98Genu recurvatum (HP:0002816)1.97952172
99Systemic lupus erythematosus (HP:0002725)1.96516492
100Hepatocellular carcinoma (HP:0001402)1.94495224
101Cupped ribs (HP:0000887)1.94418316
102Platyspondyly (HP:0000926)1.93397525
103Abnormality of alkaline phosphatase activity (HP:0004379)1.93251683
104Protuberant abdomen (HP:0001538)1.93153189
105Flat acetabular roof (HP:0003180)1.92887006
106Shallow orbits (HP:0000586)1.92573720
107Abnormality of purine metabolism (HP:0004352)1.92269251
108Bowing of the arm (HP:0006488)1.91211574
109Bowed forearm bones (HP:0003956)1.91211574
110Conjugated hyperbilirubinemia (HP:0002908)1.90940244
111Distal lower limb muscle weakness (HP:0009053)1.89476944
112Cholecystitis (HP:0001082)1.89457052
113Abnormal gallbladder physiology (HP:0012438)1.89457052
114Hyperlipoproteinemia (HP:0010980)1.89227212
115Soft skin (HP:0000977)1.88029441
116Increased mean platelet volume (HP:0011877)1.86977875
117Epidermoid cyst (HP:0200040)1.86617970
118Joint hemorrhage (HP:0005261)1.86430600
119Hand muscle atrophy (HP:0009130)1.86310769
120Mitral valve prolapse (HP:0001634)1.85559440
121J-shaped sella turcica (HP:0002680)1.85486730
122Advanced eruption of teeth (HP:0006288)1.84847409
123Natal tooth (HP:0000695)1.84259983
124Vertebral compression fractures (HP:0002953)1.84086846
125Wormian bones (HP:0002645)1.83991966
126Abnormality of nucleobase metabolism (HP:0010932)1.83601965
127Hyperglycinuria (HP:0003108)1.83048405
128Generalized aminoaciduria (HP:0002909)1.82408381
129Abnormality of liposaccharide metabolism (HP:0010968)1.80971219
130Abnormality of glycosphingolipid metabolism (HP:0004343)1.80971219
131Abnormality of glycolipid metabolism (HP:0010969)1.80971219
132Joint laxity (HP:0001388)1.80945143
133Abnormality of the acetabulum (HP:0003170)1.80613275
134Vascular calcification (HP:0004934)1.80528887
135Thin bony cortex (HP:0002753)1.80237877
136Neonatal short-limb short stature (HP:0008921)1.80053742
137Spondylolisthesis (HP:0003302)1.79465004
138Mitral regurgitation (HP:0001653)1.79364690
139Esophageal varix (HP:0002040)1.77951290
140Follicular hyperkeratosis (HP:0007502)1.77636059
141Bladder diverticulum (HP:0000015)1.75973505
142Steatorrhea (HP:0002570)1.75602918
143Ovoid vertebral bodies (HP:0003300)1.75419563
144Abnormality of the thoracic spine (HP:0100711)1.75333452
145Insulin resistance (HP:0000855)1.75274608
146Malnutrition (HP:0004395)1.74696153
147Trismus (HP:0000211)1.74094261
148Hyperextensible skin (HP:0000974)1.74049926
149Premature skin wrinkling (HP:0100678)1.73914072
150Dilatation of the ascending aorta (HP:0005111)1.73614452
151Ectopia lentis (HP:0001083)1.73358154
152Generalized amyotrophy (HP:0003700)1.71868581
153Abnormality of the umbilical cord (HP:0010881)1.71197320
154Neonatal death (HP:0003811)1.70795165
155Breech presentation (HP:0001623)1.67363481
156Glomerulonephritis (HP:0000099)1.66811952
157Insomnia (HP:0100785)1.66592650
158Broad metatarsal (HP:0001783)1.66280421

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.14043271
2TRIB33.73116277
3DDR23.29058500
4PKN23.13653187
5IRAK32.97277410
6SMG12.88418026
7PDGFRA2.56315517
8LATS12.43381225
9BCKDK2.42351570
10SIK12.37182068
11TAOK32.25339654
12FLT32.20823119
13MAPK152.18095537
14ICK1.99310119
15PASK1.96009274
16PRPF4B1.91881693
17FRK1.89246780
18PTK61.88722893
19SCYL21.80463496
20EPHA21.76500119
21MAP3K101.67834023
22MET1.55471889
23EEF2K1.51532387
24BMX1.49490789
25INSRR1.47995651
26FGFR41.47081797
27MAP3K31.46704930
28MAP3K111.45144352
29TTN1.44268812
30RIPK11.40928299
31PTK21.35511832
32LMTK21.30346286
33MST1R1.26677764
34ARAF1.25868207
35NTRK11.25439155
36DYRK1B1.24037550
37LRRK21.20354362
38PAK41.13297252
39TAOK21.10929797
40TRPM71.09411480
41MTOR1.05944710
42CDK61.03116740
43TESK11.02339423
44STK31.02054624
45PAK21.00137247
46CSK0.99842387
47PIK3CG0.97331988
48MAP2K30.97223090
49RPS6KB20.94569207
50MAP3K60.91746957
51MATK0.89202983
52KSR20.85203444
53EPHA30.84632175
54PIM20.84317326
55MYLK0.82487070
56STK100.81532349
57MAPK110.81508046
58MAP2K20.81217775
59BRSK20.81016253
60RPS6KA40.80475229
61LIMK10.79954230
62EPHB10.78444200
63GSK3A0.78369410
64PDPK10.77807747
65FER0.77705191
66CDK70.77021444
67NEK90.76401602
68MAP3K80.74641950
69PDGFRB0.74493557
70LATS20.73226398
71TAOK10.72597429
72TGFBR10.69374671
73MAPKAPK30.68994904
74TESK20.68276035
75FGFR10.68273387
76EIF2AK10.66431802
77RPS6KA20.65778689
78MAP3K10.65197982
79MAP3K130.64542414
80CDK90.64113258
81MOS0.62320198
82HIPK20.62146128
83TGFBR20.61539718
84FGFR30.60519561
85KDR0.59941997
86CDK120.59411485
87AKT30.57208543
88EPHB20.57062913
89MAP3K20.56814460
90ILK0.55830940
91CDK80.54990060
92PRKD20.54658309
93PRKD30.53253293
94CAMK1G0.52770318
95NEK20.52537250
96PRKG20.52183136
97STK38L0.51308831
98NEK10.50997750
99TYRO30.50596714
100BRAF0.48556512
101ERBB40.48386821
102STK380.47962752
103PIM10.47717289
104ABL20.45995911
105NME20.45750072
106JAK20.45398645
107EIF2AK30.45178850
108TYK20.45105292
109RPS6KL10.43999896
110RPS6KC10.43999896
111MAP3K140.42861796
112JAK30.41643040
113MARK20.41119233
114ZAP700.40977174
115CDK40.40864176
116MAPKAPK20.39627625
117CDC42BPA0.39534586
118RPS6KA60.38095516
119AURKB0.36577053
120EGFR0.36497934
121TBK10.36149216
122AKT20.35842000
123ERBB20.35258195
124MELK0.34794469
125PRKCI0.34063004
126CAMK1D0.30922442
127RET0.30791205
128ROCK20.30718757
129PAK30.29639099
130PRKAA10.29571005
131MAP2K10.29484147
132CHUK0.29173064
133IRAK20.28402169
134CLK10.27401537

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.38606750
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.71136117
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.51766302
4Selenocompound metabolism_Homo sapiens_hsa004502.23520958
5Nitrogen metabolism_Homo sapiens_hsa009102.22388759
6* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22247503
7Sulfur metabolism_Homo sapiens_hsa009202.19313040
8Tryptophan metabolism_Homo sapiens_hsa003802.11271773
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04305539
10Arginine biosynthesis_Homo sapiens_hsa002202.02019377
11Fat digestion and absorption_Homo sapiens_hsa049751.92461583
12Fatty acid degradation_Homo sapiens_hsa000711.88743790
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.86840420
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84238410
15Complement and coagulation cascades_Homo sapiens_hsa046101.82426145
16Folate biosynthesis_Homo sapiens_hsa007901.78085210
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75360938
18Protein export_Homo sapiens_hsa030601.66666123
19Starch and sucrose metabolism_Homo sapiens_hsa005001.61556775
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61269459
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58287296
22Caffeine metabolism_Homo sapiens_hsa002321.57674447
23Fatty acid metabolism_Homo sapiens_hsa012121.55049602
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54360708
25Biosynthesis of amino acids_Homo sapiens_hsa012301.48842136
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.45445546
27Arginine and proline metabolism_Homo sapiens_hsa003301.43479047
28One carbon pool by folate_Homo sapiens_hsa006701.42398269
29Galactose metabolism_Homo sapiens_hsa000521.39667760
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.38569777
31Vibrio cholerae infection_Homo sapiens_hsa051101.37304270
32Histidine metabolism_Homo sapiens_hsa003401.32924903
33N-Glycan biosynthesis_Homo sapiens_hsa005101.32289459
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29800527
35Lysine degradation_Homo sapiens_hsa003101.28270307
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23800393
37Peroxisome_Homo sapiens_hsa041461.21063736
38PPAR signaling pathway_Homo sapiens_hsa033201.20545942
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.17356528
40Chemical carcinogenesis_Homo sapiens_hsa052041.13639359
41Butanoate metabolism_Homo sapiens_hsa006501.08248186
42Propanoate metabolism_Homo sapiens_hsa006401.07992524
43Protein digestion and absorption_Homo sapiens_hsa049741.07678767
44Carbon metabolism_Homo sapiens_hsa012001.07089078
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06504938
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06135115
47Acute myeloid leukemia_Homo sapiens_hsa052211.03608449
48Pancreatic cancer_Homo sapiens_hsa052121.03064757
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01546372
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00659978
51Fatty acid biosynthesis_Homo sapiens_hsa000610.99714520
52Renin-angiotensin system_Homo sapiens_hsa046140.99484982
53Bladder cancer_Homo sapiens_hsa052190.98623556
54Vitamin digestion and absorption_Homo sapiens_hsa049770.98543638
55Glutathione metabolism_Homo sapiens_hsa004800.98256867
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98219373
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97476788
58Sulfur relay system_Homo sapiens_hsa041220.97114463
59ECM-receptor interaction_Homo sapiens_hsa045120.95794207
60Bile secretion_Homo sapiens_hsa049760.95719820
61beta-Alanine metabolism_Homo sapiens_hsa004100.92740858
62Non-small cell lung cancer_Homo sapiens_hsa052230.90159375
63Pyruvate metabolism_Homo sapiens_hsa006200.89592821
64Phenylalanine metabolism_Homo sapiens_hsa003600.89446968
65Sphingolipid metabolism_Homo sapiens_hsa006000.88741492
66Staphylococcus aureus infection_Homo sapiens_hsa051500.87917096
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87738817
68Fructose and mannose metabolism_Homo sapiens_hsa000510.87363863
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86281016
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.85963355
71ABC transporters_Homo sapiens_hsa020100.85254428
72Steroid biosynthesis_Homo sapiens_hsa001000.84548405
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.83080781
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81931864
75Lysosome_Homo sapiens_hsa041420.81862854
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80269870
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.79247674
78Prostate cancer_Homo sapiens_hsa052150.76444479
79Tyrosine metabolism_Homo sapiens_hsa003500.75332816
80Pentose phosphate pathway_Homo sapiens_hsa000300.74099250
81VEGF signaling pathway_Homo sapiens_hsa043700.74013855
82Retinol metabolism_Homo sapiens_hsa008300.73929554
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73592560
84Vitamin B6 metabolism_Homo sapiens_hsa007500.72584880
85Adherens junction_Homo sapiens_hsa045200.71898643
86Other glycan degradation_Homo sapiens_hsa005110.71615241
87Endometrial cancer_Homo sapiens_hsa052130.71400844
88Insulin signaling pathway_Homo sapiens_hsa049100.68625292
89Notch signaling pathway_Homo sapiens_hsa043300.68192289
90Focal adhesion_Homo sapiens_hsa045100.65332446
91Small cell lung cancer_Homo sapiens_hsa052220.63396018
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62555490
93Renal cell carcinoma_Homo sapiens_hsa052110.62217205
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62033506
95MicroRNAs in cancer_Homo sapiens_hsa052060.61482910
96Hepatitis C_Homo sapiens_hsa051600.60626344
97Insulin resistance_Homo sapiens_hsa049310.59387716
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.58524296
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.55371094
100Pertussis_Homo sapiens_hsa051330.54995127
101Legionellosis_Homo sapiens_hsa051340.54283683
102Shigellosis_Homo sapiens_hsa051310.54104893
103Glioma_Homo sapiens_hsa052140.54077972
104Apoptosis_Homo sapiens_hsa042100.51923577
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51852669
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.51776737
107HIF-1 signaling pathway_Homo sapiens_hsa040660.49268055
108Glycerolipid metabolism_Homo sapiens_hsa005610.48557812
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48235512
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48166130
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47305980
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.47004734
113Fatty acid elongation_Homo sapiens_hsa000620.46889342
114Amoebiasis_Homo sapiens_hsa051460.45782087
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44690321
116Proteoglycans in cancer_Homo sapiens_hsa052050.44459346
117TNF signaling pathway_Homo sapiens_hsa046680.44428182
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44423402
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44288262
120Endocytosis_Homo sapiens_hsa041440.42779650
121Hippo signaling pathway_Homo sapiens_hsa043900.42020164
122Base excision repair_Homo sapiens_hsa034100.41590906
123TGF-beta signaling pathway_Homo sapiens_hsa043500.41407727
124Hepatitis B_Homo sapiens_hsa051610.41058620
125ErbB signaling pathway_Homo sapiens_hsa040120.40748667
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40478465
127mTOR signaling pathway_Homo sapiens_hsa041500.40396775
128Salmonella infection_Homo sapiens_hsa051320.38059104
129p53 signaling pathway_Homo sapiens_hsa041150.37637427
130Prion diseases_Homo sapiens_hsa050200.37029077
131AMPK signaling pathway_Homo sapiens_hsa041520.36093940
132Chronic myeloid leukemia_Homo sapiens_hsa052200.33538397
133Thyroid hormone synthesis_Homo sapiens_hsa049180.30888603
134Thyroid cancer_Homo sapiens_hsa052160.30089760
135Metabolic pathways_Homo sapiens_hsa011000.26618996
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26616781

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