P2RY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle contraction (GO:0003009)5.65263595
2desmosome organization (GO:0002934)4.74307540
3response to peptidoglycan (GO:0032494)4.67255541
4sarcoplasmic reticulum calcium ion transport (GO:0070296)4.47651334
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.06348829
6NADH metabolic process (GO:0006734)3.85980492
7sarcomere organization (GO:0045214)3.83577159
8hemidesmosome assembly (GO:0031581)3.83343630
9positive regulation of Cdc42 GTPase activity (GO:0043089)3.82353426
10pinocytosis (GO:0006907)3.79358110
11striated muscle atrophy (GO:0014891)3.73856300
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.70645148
132-oxoglutarate metabolic process (GO:0006103)3.64066780
14hepatocyte apoptotic process (GO:0097284)3.60004634
15regulation of water loss via skin (GO:0033561)3.59277342
16glycogen catabolic process (GO:0005980)3.51584518
17actin filament-based movement (GO:0030048)3.48468563
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.46997498
19glucan catabolic process (GO:0009251)3.44913471
20actin-myosin filament sliding (GO:0033275)3.42913568
21muscle filament sliding (GO:0030049)3.42913568
22low-density lipoprotein particle clearance (GO:0034383)3.37371768
23lysine metabolic process (GO:0006553)3.35600868
24lysine catabolic process (GO:0006554)3.35600868
25cellular polysaccharide catabolic process (GO:0044247)3.35352404
26fatty acid transmembrane transport (GO:1902001)3.35257379
27regulation of sequestering of triglyceride (GO:0010889)3.34560216
28response to muscle activity (GO:0014850)3.33658434
29striated muscle contraction (GO:0006941)3.28900295
30regulation of skeletal muscle contraction (GO:0014819)3.26918421
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.26075751
32carnitine shuttle (GO:0006853)3.23375539
33positive regulation of lipid storage (GO:0010884)3.22591054
34positive regulation of keratinocyte differentiation (GO:0045618)3.21939165
35protein carboxylation (GO:0018214)3.20988269
36peptidyl-glutamic acid carboxylation (GO:0017187)3.20988269
37pentose-phosphate shunt (GO:0006098)3.20547285
38plasma lipoprotein particle clearance (GO:0034381)3.19604829
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.18478396
40protein localization to endosome (GO:0036010)3.15193374
41regulation of triglyceride catabolic process (GO:0010896)3.14605727
42muscle atrophy (GO:0014889)3.14460059
43valine metabolic process (GO:0006573)3.11725732
44plasma membrane repair (GO:0001778)3.11090636
45negative regulation of cell size (GO:0045792)3.10500242
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10375484
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.10375484
48negative regulation of necroptotic process (GO:0060546)3.07937747
49positive regulation of epidermal cell differentiation (GO:0045606)3.07698007
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.06432426
51focal adhesion assembly (GO:0048041)3.05284012
52cell-substrate adherens junction assembly (GO:0007045)3.05284012
53cell-substrate junction assembly (GO:0007044)3.00967186
54regulation of leukocyte degranulation (GO:0043300)3.00857786
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00606880
56positive regulation by symbiont of host defense response (GO:0052509)3.00365821
57modulation by symbiont of host defense response (GO:0052031)3.00365821
58modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00365821
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00365821
60positive regulation by organism of defense response of other organism involved in symbiotic interact3.00365821
61modulation by symbiont of host immune response (GO:0052553)3.00365821
62polysaccharide catabolic process (GO:0000272)2.99791276
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.99175392
64glucose catabolic process (GO:0006007)2.98816127
65epithelial cell differentiation involved in prostate gland development (GO:0060742)2.98052654
66positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97148440
67fatty acid beta-oxidation (GO:0006635)2.94992275
68establishment of skin barrier (GO:0061436)2.94655499
69phospholipid homeostasis (GO:0055091)2.93685455
70fructose metabolic process (GO:0006000)2.91678473
71complement activation, alternative pathway (GO:0006957)2.90786459
72regulation of cholesterol storage (GO:0010885)2.89283619
73disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.89265960
74killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.89265960
75detection of other organism (GO:0098543)2.88069091
76glyoxylate metabolic process (GO:0046487)2.88029501
77mannose metabolic process (GO:0006013)2.87656144
78carnitine metabolic process (GO:0009437)2.86957866
79kynurenine metabolic process (GO:0070189)2.86700587
80amino-acid betaine metabolic process (GO:0006577)2.85630153
81regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83547279
82myofibril assembly (GO:0030239)2.83509066
83sulfur amino acid catabolic process (GO:0000098)2.83251469
84regulation of necrotic cell death (GO:0010939)2.82831785
85amyloid precursor protein metabolic process (GO:0042982)2.82369479
86alpha-linolenic acid metabolic process (GO:0036109)2.82033431
87L-phenylalanine metabolic process (GO:0006558)2.81362791
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81362791
89regulation of interferon-beta biosynthetic process (GO:0045357)2.80823206
90bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80754439
91skeletal muscle fiber development (GO:0048741)2.79245170
92regulation of necroptotic process (GO:0060544)2.77505611
93glycosphingolipid catabolic process (GO:0046479)2.77437777
94activation of Rac GTPase activity (GO:0032863)2.76323535
95cysteine metabolic process (GO:0006534)2.75065916
96actin-mediated cell contraction (GO:0070252)2.73729421
97fatty acid oxidation (GO:0019395)2.73479227
98detection of bacterium (GO:0016045)2.73244833
99positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.72985950
100ethanol oxidation (GO:0006069)2.72757896
101urea metabolic process (GO:0019627)2.72308847
102urea cycle (GO:0000050)2.72308847
103oxaloacetate metabolic process (GO:0006107)2.71232724
104membrane raft organization (GO:0031579)2.70971362
105COPI coating of Golgi vesicle (GO:0048205)2.70857310
106Golgi transport vesicle coating (GO:0048200)2.70857310
107positive regulation of myotube differentiation (GO:0010831)2.70002074
108lipid oxidation (GO:0034440)2.69722409
109tricarboxylic acid metabolic process (GO:0072350)2.68738000
110cardiac myofibril assembly (GO:0055003)2.68666180
111endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66700712
112response to muramyl dipeptide (GO:0032495)2.66700705
113tricarboxylic acid cycle (GO:0006099)2.64534085
114neutrophil mediated immunity (GO:0002446)2.63611630
115regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63158128
116L-phenylalanine catabolic process (GO:0006559)2.62575800
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.62575800
118fatty acid catabolic process (GO:0009062)2.62569892
119NADPH regeneration (GO:0006740)2.62556251
120neutrophil activation involved in immune response (GO:0002283)2.61781026
121negative regulation of fibrinolysis (GO:0051918)2.61735000
122galactose catabolic process (GO:0019388)2.61623546
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.60257994
124positive regulation of p38MAPK cascade (GO:1900745)2.59993423
125carnitine transmembrane transport (GO:1902603)2.58887231
126maternal placenta development (GO:0001893)2.57755360
127regulation of mast cell degranulation (GO:0043304)2.57483682
128negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.57376293
129apoptotic cell clearance (GO:0043277)2.57241733
130skeletal muscle adaptation (GO:0043501)2.56441958
131positive regulation of lipid catabolic process (GO:0050996)2.56413284
132neutrophil activation (GO:0042119)2.55479378
133regulation of fatty acid oxidation (GO:0046320)2.55079124
134negative regulation of erythrocyte differentiation (GO:0045647)2.53980273
135regulation of protein activation cascade (GO:2000257)2.52075151
136nitrogen cycle metabolic process (GO:0071941)2.51838404
137positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.51738374
138regulation of heterotypic cell-cell adhesion (GO:0034114)2.51097013
139hypotonic response (GO:0006971)2.50856223
140regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50397616
141positive regulation of epidermis development (GO:0045684)2.49624746
142antigen processing and presentation of endogenous antigen (GO:0019883)2.49235128
143adherens junction assembly (GO:0034333)2.48703225
1443-UTR-mediated mRNA stabilization (GO:0070935)2.48623208
145macrophage activation involved in immune response (GO:0002281)2.48181174
146creatine metabolic process (GO:0006600)2.47857890
147actomyosin structure organization (GO:0031032)2.47514767
148amyloid precursor protein catabolic process (GO:0042987)2.45308299
149regulation of regulated secretory pathway (GO:1903305)2.44748952
150carnitine transport (GO:0015879)2.44610999
151amino-acid betaine transport (GO:0015838)2.44610999
152glycogen biosynthetic process (GO:0005978)2.44437557
153glucan biosynthetic process (GO:0009250)2.44437557
154intracellular estrogen receptor signaling pathway (GO:0030520)2.44103222
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43928448
156reactive oxygen species biosynthetic process (GO:1903409)2.43782267
157glycolipid catabolic process (GO:0019377)2.43605692
158aromatic amino acid family catabolic process (GO:0009074)2.42774392
159regulation of complement activation (GO:0030449)2.42284617
160regulation of relaxation of muscle (GO:1901077)2.41584418
161hydrogen peroxide biosynthetic process (GO:0050665)2.41250513
162glucose 6-phosphate metabolic process (GO:0051156)2.41180522
163positive regulation of triglyceride metabolic process (GO:0090208)2.41113282
164monocarboxylic acid catabolic process (GO:0072329)2.40914009
165aspartate family amino acid catabolic process (GO:0009068)2.40419657
166granulocyte activation (GO:0036230)2.39754125
1674-hydroxyproline metabolic process (GO:0019471)2.38876550
168killing of cells of other organism (GO:0031640)2.38576213
169disruption of cells of other organism (GO:0044364)2.38576213
170acute-phase response (GO:0006953)2.38504065
171acetyl-CoA metabolic process (GO:0006084)2.37126985
172regulation of fatty acid beta-oxidation (GO:0031998)2.36629418
173positive regulation of chemokine biosynthetic process (GO:0045080)2.36185190
174heart contraction (GO:0060047)2.35990926
175heart process (GO:0003015)2.35990926
176negative regulation of interleukin-8 production (GO:0032717)2.35523850
177multicellular organismal water homeostasis (GO:0050891)2.33476638
178epithelial cell-cell adhesion (GO:0090136)2.31770315
179striated muscle adaptation (GO:0014888)2.31695373
180lipopolysaccharide-mediated signaling pathway (GO:0031663)2.29403284
181glycogen metabolic process (GO:0005977)2.27216532
182cellular glucan metabolic process (GO:0006073)2.27176834
183glucan metabolic process (GO:0044042)2.27176834
184cardiac muscle contraction (GO:0060048)2.26960200
185cellular extravasation (GO:0045123)2.26691787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.60951848
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.52178396
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.99858198
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.86424487
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.75230112
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.22837962
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.07683113
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.66062198
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52737212
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52579957
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49158381
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.34021954
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.25272541
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23446674
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23377271
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19356597
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19260269
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18195791
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06768748
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06765843
21NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05283731
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.03457917
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.02490922
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99629447
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98405032
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.94987180
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91234669
28GATA1_22025678_ChIP-Seq_K562_Human1.90227877
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90072603
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88835098
31CLOCK_20551151_ChIP-Seq_293T_Human1.84507890
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76182533
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.75753451
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74758611
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70249902
36SCL_19346495_ChIP-Seq_HPC-7_Human1.69347209
37ZNF263_19887448_ChIP-Seq_K562_Human1.68326879
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66669578
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65764496
40* RUNX1_27514584_Chip-Seq_MCF-7_Human1.61955062
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.57501859
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56355219
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55188843
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51173048
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.49454054
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49401704
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.45229954
48* VDR_21846776_ChIP-Seq_THP-1_Human1.43993710
49* TBX20_22080862_ChIP-Seq_HEART_Mouse1.36151902
50* TBX20_22328084_ChIP-Seq_HEART_Mouse1.36151902
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35236289
52* VDR_24763502_ChIP-Seq_THP-1_Human1.34769606
53LXR_22292898_ChIP-Seq_THP-1_Human1.32530967
54MAF_26560356_Chip-Seq_TH1_Human1.31361212
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29419331
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29090723
57* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26563113
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26446214
59TCF7_22412390_ChIP-Seq_EML_Mouse1.25972013
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.25882189
61SPI1_23127762_ChIP-Seq_K562_Human1.25766274
62P68_20966046_ChIP-Seq_HELA_Human1.22886974
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22434950
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22142419
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.20960230
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19672921
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.19586179
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19349674
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17808415
70RACK7_27058665_Chip-Seq_MCF-7_Human1.15912084
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.15814686
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15670160
73ATF3_27146783_Chip-Seq_COLON_Human1.14714004
74GATA6_25053715_ChIP-Seq_YYC3_Human1.14471849
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13921584
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13135270
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12897193
78MAF_26560356_Chip-Seq_TH2_Human1.12447611
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11477980
80BCOR_27268052_Chip-Seq_Bcells_Human1.10973867
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10863061
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.10558860
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09039049
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08988200
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08621076
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08585199
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08480747
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08399416
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07896196
90* SA1_27219007_Chip-Seq_ERYTHROID_Human1.07815145
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07721876
92SPI1_23547873_ChIP-Seq_NB4_Human1.07516229
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07217273
94* GATA2_19941826_ChIP-Seq_K562_Human1.05929533
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05642160
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05596765
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05162955
98SMC4_20622854_ChIP-Seq_HELA_Human1.05043145
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04931919
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04779308
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04741994
102CREB1_26743006_Chip-Seq_LNCaP_Human1.04040551
103GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03920103
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03730640
105NCOR1_26117541_ChIP-Seq_K562_Human1.02918531
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02421654
107GATA1_19941826_ChIP-Seq_K562_Human1.02329402
108SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02087647
109UTX_26944678_Chip-Seq_JUKART_Human1.01524668
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00800517
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00614396
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99276597
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99147562
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99109469
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99044997
116MYC_22102868_ChIP-Seq_BL_Human0.98846580
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98548178
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.98537164
119PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98073299
120GATA3_24758297_ChIP-Seq_MCF-7_Human0.97529862
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96924089
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96545062
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.96192881
124* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95617853
125* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95350526
126* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93203546
127KDM2B_26808549_Chip-Seq_DND41_Human0.92716211
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92401580
129GATA4_25053715_ChIP-Seq_YYC3_Human0.92048382
130PU_27001747_Chip-Seq_BMDM_Mouse0.91395330
131* SOX2_20726797_ChIP-Seq_SW620_Human0.90672476
132SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90453999
133VDR_24787735_ChIP-Seq_THP-1_Human0.89811232
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.88673331
135EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88578956
136* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88463291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.17187503
2MP0010234_abnormal_vibrissa_follicle3.64171034
3MP0002837_dystrophic_cardiac_calcinosis3.15702823
4MP0002139_abnormal_hepatobiliary_system3.09053275
5MP0002796_impaired_skin_barrier2.99441835
6MP0005360_urolithiasis2.96216991
7MP0003646_muscle_fatigue2.95929265
8MP0009840_abnormal_foam_cell2.63162465
9MP0004264_abnormal_extraembryonic_tissu2.52828849
10MP0003303_peritoneal_inflammation2.39844017
11MP0005085_abnormal_gallbladder_physiolo2.38059002
12MP0003436_decreased_susceptibility_to2.31174898
13MP0000751_myopathy2.29563944
14MP0005365_abnormal_bile_salt2.22159989
15MP0004233_abnormal_muscle_weight2.22085816
16MP0004185_abnormal_adipocyte_glucose2.21247712
17MP0000749_muscle_degeneration2.19393614
18MP0004084_abnormal_cardiac_muscle2.18204688
19MP0008260_abnormal_autophagy2.17110697
20MP0008875_abnormal_xenobiotic_pharmacok2.04831068
21MP0004145_abnormal_muscle_electrophysio2.01515885
22MP0000343_altered_response_to2.00539159
23MP0003806_abnormal_nucleotide_metabolis1.94190604
24MP0005076_abnormal_cell_differentiation1.93628557
25MP0003191_abnormal_cellular_cholesterol1.90001169
26MP0003705_abnormal_hypodermis_morpholog1.87070840
27MP0003453_abnormal_keratinocyte_physiol1.86893734
28MP0004130_abnormal_muscle_cell1.85883501
29MP0004036_abnormal_muscle_relaxation1.85181317
30MP0003724_increased_susceptibility_to1.84353916
31MP0005501_abnormal_skin_physiology1.84135017
32MP0005330_cardiomyopathy1.83800471
33MP0005083_abnormal_biliary_tract1.81136642
34MP0009785_altered_susceptibility_to1.77221096
35MP0004510_myositis1.76431597
36MP0000750_abnormal_muscle_regeneration1.70941836
37MP0003828_pulmonary_edema1.70777303
38MP0003300_gastrointestinal_ulcer1.66947039
39MP0003252_abnormal_bile_duct1.66412264
40MP0004087_abnormal_muscle_fiber1.62498718
41MP0005058_abnormal_lysosome_morphology1.58225540
42MP0002419_abnormal_innate_immunity1.57540998
43MP0010329_abnormal_lipoprotein_level1.57309627
44MP0004381_abnormal_hair_follicle1.57274023
45MP0001835_abnormal_antigen_presentation1.51795667
46MP0005319_abnormal_enzyme/_coenzyme1.51285516
47MP0004215_abnormal_myocardial_fiber1.50137204
48MP0005025_abnormal_response_to1.48042299
49MP0001853_heart_inflammation1.46887255
50MP0000579_abnormal_nail_morphology1.44682405
51MP0003656_abnormal_erythrocyte_physiolo1.42555256
52MP0009764_decreased_sensitivity_to1.42056479
53MP0005464_abnormal_platelet_physiology1.41364348
54MP0001216_abnormal_epidermal_layer1.40126542
55MP0000733_abnormal_muscle_development1.39052648
56MP0000609_abnormal_liver_physiology1.35793857
57MP0003566_abnormal_cell_adhesion1.35650365
58MP0002972_abnormal_cardiac_muscle1.35370465
59MP0002060_abnormal_skin_morphology1.33683153
60MP0010678_abnormal_skin_adnexa1.33125471
61MP0003195_calcinosis1.32906563
62MP0000467_abnormal_esophagus_morphology1.32246187
63MP0010630_abnormal_cardiac_muscle1.30754977
64MP0001533_abnormal_skeleton_physiology1.30377973
65MP0005385_cardiovascular_system_phenoty1.28516407
66MP0001544_abnormal_cardiovascular_syste1.28516407
67MP0002877_abnormal_melanocyte_morpholog1.27510899
68MP0009278_abnormal_bone_marrow1.26412375
69MP0002106_abnormal_muscle_physiology1.25289411
70MP0008469_abnormal_protein_level1.25185492
71MP0002138_abnormal_hepatobiliary_system1.25009082
72MP0003221_abnormal_cardiomyocyte_apopto1.24909211
73MP0004947_skin_inflammation1.24312933
74MP0005332_abnormal_amino_acid1.23878473
75MP0002148_abnormal_hypersensitivity_rea1.23370073
76MP0003186_abnormal_redox_activity1.20758474
77MP0002269_muscular_atrophy1.19159294
78MP0003172_abnormal_lysosome_physiology1.17693829
79MP0010368_abnormal_lymphatic_system1.17369304
80MP0003075_altered_response_to1.17117032
81MP0002118_abnormal_lipid_homeostasis1.11943099
82MP0002098_abnormal_vibrissa_morphology1.11603595
83MP0005620_abnormal_muscle_contractility1.11492788
84MP0005000_abnormal_immune_tolerance1.11178825
85MP0005166_decreased_susceptibility_to1.09460892
86MP0001845_abnormal_inflammatory_respons1.09097463
87MP0000747_muscle_weakness1.08961224
88MP0005666_abnormal_adipose_tissue1.08325576
89MP0000858_altered_metastatic_potential1.06653679
90MP0008775_abnormal_heart_ventricle1.05866127
91MP0001666_abnormal_nutrient_absorption1.05775962
92MP0005375_adipose_tissue_phenotype1.05161452
93MP0005023_abnormal_wound_healing1.05061271
94MP0004782_abnormal_surfactant_physiolog1.04384618
95MP0001849_ear_inflammation1.03866861
96MP0005584_abnormal_enzyme/coenzyme_acti1.03716645
97MP0006082_CNS_inflammation1.03296414
98MP0006036_abnormal_mitochondrial_physio1.02813791
99MP0002396_abnormal_hematopoietic_system1.01835889
100MP0010155_abnormal_intestine_physiology1.01423450
101MP0009931_abnormal_skin_appearance1.00790334
102MP0008438_abnormal_cutaneous_collagen1.00029409
103MP0000759_abnormal_skeletal_muscle0.99804618
104MP0000685_abnormal_immune_system0.99754449
105MP0005266_abnormal_metabolism0.97828130
106MP0010352_gastrointestinal_tract_polyps0.96872962
107MP0001545_abnormal_hematopoietic_system0.96610655
108MP0005397_hematopoietic_system_phenotyp0.96610655
109MP0005167_abnormal_blood-brain_barrier0.96409189
110MP0009763_increased_sensitivity_to0.96359274
111MP0002452_abnormal_antigen_presenting0.95992861
112MP0005409_darkened_coat_color0.95907608
113MP0006138_congestive_heart_failure0.93719203
114MP0000383_abnormal_hair_follicle0.93560036
115MP0003279_aneurysm0.93487405
116MP0001790_abnormal_immune_system0.92137749
117MP0005387_immune_system_phenotype0.92137749
118MP0004484_altered_response_of0.92107858
119MP0005165_increased_susceptibility_to0.91960108
120MP0000377_abnormal_hair_follicle0.90695176
121MP0009643_abnormal_urine_homeostasis0.90629844
122MP0005369_muscle_phenotype0.90258899
123MP0002166_altered_tumor_susceptibility0.90190759
124MP0000604_amyloidosis0.88225686
125MP0002723_abnormal_immune_serum0.87984156
126MP0000762_abnormal_tongue_morphology0.87897276
127MP0002332_abnormal_exercise_endurance0.87391410
128MP0001873_stomach_inflammation0.84858632
129MP0000598_abnormal_liver_morphology0.83555848
130MP0000249_abnormal_blood_vessel0.82627890
131MP0001958_emphysema0.82612449
132MP0001800_abnormal_humoral_immune0.82582275
133MP0002405_respiratory_system_inflammati0.82559681
134MP0010771_integument_phenotype0.81923300
135MP0009333_abnormal_splenocyte_physiolog0.80702230
136MP0000678_abnormal_parathyroid_gland0.74451386
137MP0002998_abnormal_bone_remodeling0.70933803
138MP0005248_abnormal_Harderian_gland0.69755165
139MP0001819_abnormal_immune_cell0.69132576
140MP0002420_abnormal_adaptive_immunity0.69062129
141MP0003329_amyloid_beta_deposits0.67302237
142MP0003763_abnormal_thymus_physiology0.65956480

Predicted human phenotypes

RankGene SetZ-score
1Myopathic facies (HP:0002058)4.34327376
2Centrally nucleated skeletal muscle fibers (HP:0003687)4.22639784
3Distal lower limb amyotrophy (HP:0008944)4.03196167
4Exercise-induced muscle cramps (HP:0003710)3.94011038
5Ventricular tachycardia (HP:0004756)3.79265250
6Asymmetric septal hypertrophy (HP:0001670)3.70493024
7Exercise-induced myalgia (HP:0003738)3.60584120
8Sudden death (HP:0001699)3.59246766
9Right ventricular cardiomyopathy (HP:0011663)3.48699922
10Muscle fiber splitting (HP:0003555)3.46886222
11Calf muscle hypertrophy (HP:0008981)3.46105763
12Increased connective tissue (HP:0009025)3.43517082
13Neck muscle weakness (HP:0000467)3.43123783
14Recurrent gram-negative bacterial infections (HP:0005420)3.42525510
15Myoglobinuria (HP:0002913)3.32322674
16Muscle hypertrophy of the lower extremities (HP:0008968)3.22923696
17Hyporeflexia of lower limbs (HP:0002600)3.19684655
18Xanthomatosis (HP:0000991)3.13100394
19Deep venous thrombosis (HP:0002625)3.12536305
20Progressive muscle weakness (HP:0003323)3.10422246
21Abnormality of skeletal muscle fiber size (HP:0012084)3.06962357
22Eczematoid dermatitis (HP:0000976)3.02832041
23Lipoatrophy (HP:0100578)2.98409074
24Muscle fiber inclusion bodies (HP:0100299)2.88129372
25Rhabdomyolysis (HP:0003201)2.85508220
26EMG: myopathic abnormalities (HP:0003458)2.84117848
27Axonal loss (HP:0003447)2.83234696
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.77818388
29Abnormality of fatty-acid metabolism (HP:0004359)2.77534256
30Bulbar palsy (HP:0001283)2.76262957
31Recurrent abscess formation (HP:0002722)2.74456097
32Palpitations (HP:0001962)2.71565601
33Abnormality of the left ventricular outflow tract (HP:0011103)2.69152607
34Subaortic stenosis (HP:0001682)2.69152607
35Mildly elevated creatine phosphokinase (HP:0008180)2.69082126
36Intrahepatic cholestasis (HP:0001406)2.67231463
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66080529
38Abnormality of the calf musculature (HP:0001430)2.64503731
39Systemic lupus erythematosus (HP:0002725)2.60682651
40Ragged-red muscle fibers (HP:0003200)2.59316447
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56092850
42Hypoglycemic coma (HP:0001325)2.55874309
43Abnormality of nail color (HP:0100643)2.55292412
44Recurrent bacterial skin infections (HP:0005406)2.54951113
45Abnormality of macrophages (HP:0004311)2.52686557
46Round ear (HP:0100830)2.52198372
47Nausea (HP:0002018)2.51722787
48Prolonged partial thromboplastin time (HP:0003645)2.51225510
49Hyperammonemia (HP:0001987)2.51209964
50Difficulty running (HP:0009046)2.51124135
51Hypoalphalipoproteinemia (HP:0003233)2.50808615
52Complement deficiency (HP:0004431)2.50075634
53Hyperlipoproteinemia (HP:0010980)2.48275143
54Ketosis (HP:0001946)2.47704306
55Vacuolated lymphocytes (HP:0001922)2.46009642
56Type 1 muscle fiber predominance (HP:0003803)2.44936761
57Lower limb amyotrophy (HP:0007210)2.44581336
58Abnormality of the common coagulation pathway (HP:0010990)2.41092370
59Myocardial infarction (HP:0001658)2.39683914
60Joint hemorrhage (HP:0005261)2.39272647
61Dilated cardiomyopathy (HP:0001644)2.38432008
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36633386
63Nemaline bodies (HP:0003798)2.36239802
64Increased variability in muscle fiber diameter (HP:0003557)2.35725741
65Elevated erythrocyte sedimentation rate (HP:0003565)2.35168523
66Atrial fibrillation (HP:0005110)2.30545105
67EMG: neuropathic changes (HP:0003445)2.24441784
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.24379488
69Ketoacidosis (HP:0001993)2.22203804
70Esophageal neoplasm (HP:0100751)2.21901682
71Neoplasm of head and neck (HP:0012288)2.21901682
72Increased serum ferritin (HP:0003281)2.19804457
73Difficulty climbing stairs (HP:0003551)2.19269953
74Hypolipoproteinemia (HP:0010981)2.18329177
75Abnormality of complement system (HP:0005339)2.17087224
76Areflexia of lower limbs (HP:0002522)2.15012416
77Distal lower limb muscle weakness (HP:0009053)2.13911421
78Dicarboxylic aciduria (HP:0003215)2.13472362
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13472362
80Muscle stiffness (HP:0003552)2.12047031
81Broad face (HP:0000283)2.11772224
82Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11427921
83Primary atrial arrhythmia (HP:0001692)2.11046057
84Fatigable weakness (HP:0003473)2.09542425
85Abnormality of the neuromuscular junction (HP:0003398)2.09542425
86Thick nail (HP:0001805)2.08703263
87Esophageal varix (HP:0002040)2.08441737
88Fatigue (HP:0012378)2.07757477
89Abnormality of iron homeostasis (HP:0011031)2.07363208
90Distal arthrogryposis (HP:0005684)2.06420984
91Facial diplegia (HP:0001349)2.05448509
92Malignant hyperthermia (HP:0002047)2.04979920
93Interstitial pulmonary disease (HP:0006530)2.04803770
94Hypercholesterolemia (HP:0003124)2.03517118
95Supraventricular tachycardia (HP:0004755)2.03497939
96Abnormality of proline metabolism (HP:0010907)2.02073322
97Hydroxyprolinuria (HP:0003080)2.02073322
98Supraventricular arrhythmia (HP:0005115)2.01511741
99Hypobetalipoproteinemia (HP:0003563)2.01493736
100Hyperglycinuria (HP:0003108)2.01464684
101Achilles tendon contracture (HP:0001771)2.01143191
102Micronodular cirrhosis (HP:0001413)2.00314017
103Foot dorsiflexor weakness (HP:0009027)2.00310253
104Rimmed vacuoles (HP:0003805)1.99220514
105Amyloidosis (HP:0011034)1.99087735
106Diaphragmatic weakness (HP:0009113)1.98602950
107Alopecia of scalp (HP:0002293)1.97362479
108Flat acetabular roof (HP:0003180)1.96926845
109Bundle branch block (HP:0011710)1.96858120
110Milia (HP:0001056)1.96388337
111Paralysis (HP:0003470)1.95030825
112Atrioventricular block (HP:0001678)1.94901717
113Generalized muscle weakness (HP:0003324)1.94130761
114Frequent falls (HP:0002359)1.93532301
115Increased cerebral lipofuscin (HP:0011813)1.93512162
116Ulnar deviation of the wrist (HP:0003049)1.93179881
117Ridged nail (HP:0001807)1.92172632
118Abnormality of liposaccharide metabolism (HP:0010968)1.92090148
119Abnormality of glycosphingolipid metabolism (HP:0004343)1.92090148
120Abnormality of glycolipid metabolism (HP:0010969)1.92090148
121Cholelithiasis (HP:0001081)1.91956564
122Short nail (HP:0001799)1.90664654
123Hematochezia (HP:0002573)1.89966857
124Abnormality of transition element cation homeostasis (HP:0011030)1.89738714
125Generalized aminoaciduria (HP:0002909)1.89333632
126Gingival bleeding (HP:0000225)1.88780036
127Easy fatigability (HP:0003388)1.88217782
128Abnormality of the foot musculature (HP:0001436)1.87764783
129Skin nodule (HP:0200036)1.87580640
130Plantar hyperkeratosis (HP:0007556)1.87153810
131Onycholysis (HP:0001806)1.85581718
132Myotonia (HP:0002486)1.85440195
133Abnormal atrioventricular conduction (HP:0005150)1.85259699
134Abnormality of the intrinsic pathway (HP:0010989)1.85202711
135Heart block (HP:0012722)1.84645344
136Urticaria (HP:0001025)1.84148133
137Polycythemia (HP:0001901)1.83094895
138Abnormality of purine metabolism (HP:0004352)1.82351142
139Tetraparesis (HP:0002273)1.82339421
140Nail dystrophy (HP:0008404)1.81746717
141Limb-girdle muscle atrophy (HP:0003797)1.81701321
142Ventricular arrhythmia (HP:0004308)1.81425680
143Reduced subcutaneous adipose tissue (HP:0003758)1.80924147
144Pili torti (HP:0003777)1.79465526
145Fragile nails (HP:0001808)1.76585453
146Abnormality of the Achilles tendon (HP:0005109)1.75537229
147Scapular winging (HP:0003691)1.72490823
148Gingivitis (HP:0000230)1.71747023
149Osteolytic defects of the hand bones (HP:0009699)1.71521676
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.71521676
151Increased IgE level (HP:0003212)1.71016126
152Increased neuronal autofluorescent lipopigment (HP:0002074)1.70255580
153Trismus (HP:0000211)1.68087690
154J-shaped sella turcica (HP:0002680)1.67018863
155Hyperkalemia (HP:0002153)1.65794373
156Weak cry (HP:0001612)1.64833451
157Generalized amyotrophy (HP:0003700)1.64263865
158Microglossia (HP:0000171)1.63500779
159Abnormal blistering of the skin (HP:0008066)1.59832621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.46620684
2ERN13.54618930
3PKN23.23299197
4TRIB33.10865405
5OBSCN2.79274041
6BCKDK2.70284589
7TBK12.37486626
8MAP2K32.29058615
9FLT32.14346322
10PRPF4B2.13575281
11MYLK2.01615760
12MAP3K31.90946359
13KIT1.89524432
14SMG11.87998977
15TYK21.81750483
16EPHB11.78357065
17TESK21.69786915
18RIPK41.65109138
19TAOK31.59827930
20RIPK11.54647873
21MAP3K111.54392166
22TIE11.53469094
23MAP4K11.50853655
24TESK11.47043380
25DMPK1.46861105
26IRAK31.44579211
27MST1R1.42951436
28PHKG21.41223469
29PHKG11.41223469
30BLK1.39776933
31LMTK21.39122562
32TGFBR21.35200977
33SIK11.34311274
34PIM21.31881403
35PTK61.31734230
36PIK3CA1.31491806
37TRPM71.29334126
38MAPKAPK31.26129226
39EEF2K1.23551747
40NEK91.23530187
41MAP3K141.21813261
42ICK1.18942827
43GRK61.17289657
44FGFR41.16412127
45NME21.13166833
46ABL21.11115049
47LRRK21.10940019
48KDR1.09212736
49PIK3CG1.09135429
50CDK121.00840791
51ZAP700.99157499
52IKBKE0.99077079
53JAK10.97279260
54CSF1R0.96811936
55IRAK20.96579971
56TEC0.94894165
57BTK0.94465981
58MAP3K60.92328458
59PRKG20.91453661
60JAK30.89148510
61IRAK40.88493904
62MAP3K70.87549036
63MAP3K50.86707469
64CSK0.86280069
65NME10.85819408
66IKBKB0.85363607
67STK100.84589103
68MUSK0.84090777
69TAOK10.83934199
70MAP3K10.83364037
71RPS6KA40.81188394
72MATK0.78876768
73JAK20.78483485
74MAP2K40.76863518
75MAP3K130.75968506
76ARAF0.75834379
77PDK30.73872529
78PDK40.73872529
79MAPK120.72608461
80BMX0.72558313
81MET0.71673100
82PAK40.71056216
83PRKAA20.70015044
84MAP3K100.70010522
85MTOR0.69107864
86PDK20.68267990
87MAP3K120.64555183
88HCK0.64207807
89TGFBR10.62420906
90TAOK20.62007371
91MOS0.60529428
92MAP2K60.59924157
93MAPK40.58125477
94PINK10.57804504
95CAMK2G0.57787091
96MAP3K20.57774318
97DAPK30.57538333
98EPHA20.57121804
99RPS6KA20.57095653
100LATS20.56743086
101MAP2K10.56308193
102RPS6KA60.56286716
103NEK10.55198307
104STK40.54568510
105MAPK110.54534749
106KSR20.54063550
107ILK0.53426489
108LIMK10.52692827
109CHUK0.51101329
110MAPKAPK20.50913358
111MAP2K20.50347815
112RPS6KC10.50029749
113RPS6KL10.50029749
114SYK0.48821645
115PDK10.47237222
116EPHA30.47185966
117PRKD10.47104076
118PTK20.46783534
119ITK0.44478885
120MAP3K80.43892221
121PRKD20.43051265
122SIK30.42693610
123PDPK10.40614807
124MAPK70.40558154
125MAP3K90.40332993
126CAMK1D0.39496451
127MARK20.38766781
128PIM10.38765428
129STK240.38138763
130AKT20.38018366
131PDGFRA0.37310757
132EGFR0.37120262
133RET0.36979095
134SCYL20.36040300
135LCK0.35094861
136RPS6KB20.34703040
137PRKAA10.33634456
138CAMK2D0.31285612
139RPS6KA10.30788199

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96639060
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71210716
3Fatty acid degradation_Homo sapiens_hsa000712.66678613
4Arginine biosynthesis_Homo sapiens_hsa002202.50083470
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.46827207
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44109235
7Staphylococcus aureus infection_Homo sapiens_hsa051502.39361787
8Caffeine metabolism_Homo sapiens_hsa002322.31356196
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14753280
10Complement and coagulation cascades_Homo sapiens_hsa046102.12395574
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06489280
12Propanoate metabolism_Homo sapiens_hsa006402.03461665
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93298167
14PPAR signaling pathway_Homo sapiens_hsa033201.80818972
15Starch and sucrose metabolism_Homo sapiens_hsa005001.77151395
16Tryptophan metabolism_Homo sapiens_hsa003801.72705584
17Nitrogen metabolism_Homo sapiens_hsa009101.70742403
18Carbon metabolism_Homo sapiens_hsa012001.69036157
19Fatty acid metabolism_Homo sapiens_hsa012121.62773916
20Leishmaniasis_Homo sapiens_hsa051401.61390281
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56952823
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55655740
23Thyroid cancer_Homo sapiens_hsa052161.50878944
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50506781
25Non-small cell lung cancer_Homo sapiens_hsa052231.50128812
26Peroxisome_Homo sapiens_hsa041461.48797321
27Bladder cancer_Homo sapiens_hsa052191.47838143
28VEGF signaling pathway_Homo sapiens_hsa043701.44505500
29beta-Alanine metabolism_Homo sapiens_hsa004101.39752719
30Chronic myeloid leukemia_Homo sapiens_hsa052201.32325911
31Renal cell carcinoma_Homo sapiens_hsa052111.31932782
32Pancreatic cancer_Homo sapiens_hsa052121.30648128
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28523825
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23193619
35Histidine metabolism_Homo sapiens_hsa003401.21319181
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.20264142
37Legionellosis_Homo sapiens_hsa051341.19319179
38Pyruvate metabolism_Homo sapiens_hsa006201.17966928
39Endometrial cancer_Homo sapiens_hsa052131.17128880
40Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14697240
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14029486
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13664167
43Biosynthesis of amino acids_Homo sapiens_hsa012301.13010382
44Pertussis_Homo sapiens_hsa051331.11969997
45Malaria_Homo sapiens_hsa051441.10179964
46Glucagon signaling pathway_Homo sapiens_hsa049221.09502917
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08424377
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07890644
49AMPK signaling pathway_Homo sapiens_hsa041521.06821006
50Sulfur relay system_Homo sapiens_hsa041221.06734191
51Insulin resistance_Homo sapiens_hsa049311.06547561
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05474828
53Dilated cardiomyopathy_Homo sapiens_hsa054141.05386120
54Galactose metabolism_Homo sapiens_hsa000521.04825928
55Selenocompound metabolism_Homo sapiens_hsa004501.00378144
56Osteoclast differentiation_Homo sapiens_hsa043800.98625082
57Sulfur metabolism_Homo sapiens_hsa009200.98141753
58Butanoate metabolism_Homo sapiens_hsa006500.96377324
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96069007
60Chemical carcinogenesis_Homo sapiens_hsa052040.94995709
61Viral myocarditis_Homo sapiens_hsa054160.94842785
62Notch signaling pathway_Homo sapiens_hsa043300.94701363
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94592817
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.94097376
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93106184
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92315645
67Arginine and proline metabolism_Homo sapiens_hsa003300.91783861
68GnRH signaling pathway_Homo sapiens_hsa049120.91470803
69Fat digestion and absorption_Homo sapiens_hsa049750.88509030
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88425583
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88218236
72Amoebiasis_Homo sapiens_hsa051460.87305972
73Other glycan degradation_Homo sapiens_hsa005110.86072649
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82711692
75ABC transporters_Homo sapiens_hsa020100.82447154
76Lysosome_Homo sapiens_hsa041420.82430761
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82141691
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.80812678
79Bile secretion_Homo sapiens_hsa049760.80497066
80Folate biosynthesis_Homo sapiens_hsa007900.80241732
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.79665697
82mTOR signaling pathway_Homo sapiens_hsa041500.79475500
83Pentose phosphate pathway_Homo sapiens_hsa000300.79472475
84ErbB signaling pathway_Homo sapiens_hsa040120.79122381
85Tuberculosis_Homo sapiens_hsa051520.78317559
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78001590
87Phenylalanine metabolism_Homo sapiens_hsa003600.77867502
88Toxoplasmosis_Homo sapiens_hsa051450.75762460
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73680938
90TNF signaling pathway_Homo sapiens_hsa046680.71869370
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71269152
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.70036094
93Endocytosis_Homo sapiens_hsa041440.69966337
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69914414
95Proteoglycans in cancer_Homo sapiens_hsa052050.68188645
96Fructose and mannose metabolism_Homo sapiens_hsa000510.67753230
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.67577871
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67066986
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.66754283
100Hepatitis B_Homo sapiens_hsa051610.66192943
101Lysine degradation_Homo sapiens_hsa003100.64980953
102Platelet activation_Homo sapiens_hsa046110.64788008
103Retinol metabolism_Homo sapiens_hsa008300.63776376
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63691814
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62160239
106Salmonella infection_Homo sapiens_hsa051320.61909351
107Acute myeloid leukemia_Homo sapiens_hsa052210.61360208
108Cardiac muscle contraction_Homo sapiens_hsa042600.61201641
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60906821
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.59535788
111Fatty acid elongation_Homo sapiens_hsa000620.59504008
112Prolactin signaling pathway_Homo sapiens_hsa049170.58967001
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58618407
114Renin-angiotensin system_Homo sapiens_hsa046140.58456525
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57631974
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57601437
117B cell receptor signaling pathway_Homo sapiens_hsa046620.56746223
118Inositol phosphate metabolism_Homo sapiens_hsa005620.56628897
119T cell receptor signaling pathway_Homo sapiens_hsa046600.53180419
120Phagosome_Homo sapiens_hsa041450.52123364
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51505136
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50478863
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.49976220
124HIF-1 signaling pathway_Homo sapiens_hsa040660.49394887
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.49204589
126Glioma_Homo sapiens_hsa052140.48865218
127Choline metabolism in cancer_Homo sapiens_hsa052310.48559866
128Influenza A_Homo sapiens_hsa051640.48022863
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.47613786
130Hematopoietic cell lineage_Homo sapiens_hsa046400.46364725
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45845494
132Apoptosis_Homo sapiens_hsa042100.45770020
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.45308340
134Glutathione metabolism_Homo sapiens_hsa004800.44991320
135FoxO signaling pathway_Homo sapiens_hsa040680.44613807
136Estrogen signaling pathway_Homo sapiens_hsa049150.43101981
137Insulin signaling pathway_Homo sapiens_hsa049100.42896722
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42641536
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42190487
140Focal adhesion_Homo sapiens_hsa045100.41873090
141AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41396006
142Hepatitis C_Homo sapiens_hsa051600.39225684
143Small cell lung cancer_Homo sapiens_hsa052220.39138521
144Glycerolipid metabolism_Homo sapiens_hsa005610.37986535
145ECM-receptor interaction_Homo sapiens_hsa045120.37409250
146Shigellosis_Homo sapiens_hsa051310.37082155

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