P2RX7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.22007069
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.22007069
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.22007069
4modulation by symbiont of host immune response (GO:0052553)6.22007069
5positive regulation by symbiont of host defense response (GO:0052509)6.22007069
6modulation by symbiont of host defense response (GO:0052031)6.22007069
7regulation of interferon-beta biosynthetic process (GO:0045357)5.42007172
8microglial cell activation (GO:0001774)5.23773685
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.12190145
10macrophage activation involved in immune response (GO:0002281)4.88556676
11regulation of B cell receptor signaling pathway (GO:0050855)4.37125947
12negative regulation of granulocyte differentiation (GO:0030853)4.29131238
13tolerance induction (GO:0002507)4.23968893
14regulation of chronic inflammatory response (GO:0002676)4.19046528
15positive regulation of gamma-delta T cell activation (GO:0046645)4.19028391
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07683488
17negative regulation of cell killing (GO:0031342)4.07683488
18regulation of vitamin D biosynthetic process (GO:0060556)4.03157388
19regulation of T-helper 1 cell differentiation (GO:0045625)4.01491515
20positive regulation of chemokine secretion (GO:0090197)3.99745192
21positive regulation of interferon-alpha production (GO:0032727)3.99553159
22regulation of interferon-alpha production (GO:0032647)3.95641922
23macrophage activation (GO:0042116)3.89605732
24response to host immune response (GO:0052572)3.88917315
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88917315
26positive regulation of cellular amide metabolic process (GO:0034250)3.70089788
27type I interferon signaling pathway (GO:0060337)3.68153997
28cellular response to type I interferon (GO:0071357)3.68153997
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.64502118
30response to host (GO:0075136)3.64502118
31response to host defenses (GO:0052200)3.64502118
32response to type I interferon (GO:0034340)3.64236705
33positive regulation of heat generation (GO:0031652)3.62956386
34positive regulation of B cell differentiation (GO:0045579)3.57684571
35neutrophil activation involved in immune response (GO:0002283)3.55386680
36interferon-gamma-mediated signaling pathway (GO:0060333)3.54589488
37cellular extravasation (GO:0045123)3.53314913
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49831402
39myeloid cell activation involved in immune response (GO:0002275)3.49129826
40positive regulation of type 2 immune response (GO:0002830)3.48721833
41mannose metabolic process (GO:0006013)3.47844686
42negative regulation of interleukin-12 production (GO:0032695)3.45336785
43regulation of T cell tolerance induction (GO:0002664)3.40891301
44regulation of fever generation (GO:0031620)3.40534491
45I-kappaB phosphorylation (GO:0007252)3.40362484
46leukocyte aggregation (GO:0070486)3.38085508
47G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.37326301
48detection of molecule of bacterial origin (GO:0032490)3.35829164
49positive thymic T cell selection (GO:0045059)3.33359740
50positive regulation of antigen processing and presentation (GO:0002579)3.31406008
51regulation of chemokine secretion (GO:0090196)3.28434248
52T cell migration (GO:0072678)3.25676178
53pinocytosis (GO:0006907)3.22542596
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.22410486
55defense response to protozoan (GO:0042832)3.22097148
56regulation of interleukin-12 production (GO:0032655)3.21403137
57immunoglobulin mediated immune response (GO:0016064)3.20764628
58regulation of cytokine secretion involved in immune response (GO:0002739)3.20746659
59T-helper 1 type immune response (GO:0042088)3.18225856
60response to muramyl dipeptide (GO:0032495)3.17724457
61regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16865581
62negative regulation of interleukin-6 production (GO:0032715)3.09533666
63regulation of mast cell degranulation (GO:0043304)3.09407116
64mast cell activation (GO:0045576)3.08501284
65negative regulation of B cell proliferation (GO:0030889)3.08251183
66positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.07398268
67response to protozoan (GO:0001562)3.07116682
68positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.06152872
69regulation of heat generation (GO:0031650)3.04920274
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03471965
71negative regulation of cytokine production involved in immune response (GO:0002719)3.02972069
72positive regulation of chemokine biosynthetic process (GO:0045080)3.02571687
73regulation of vitamin metabolic process (GO:0030656)2.98604654
74positive regulation of NF-kappaB import into nucleus (GO:0042346)2.97704244
75tryptophan catabolic process (GO:0006569)2.96167479
76indole-containing compound catabolic process (GO:0042436)2.96167479
77indolalkylamine catabolic process (GO:0046218)2.96167479
78regulation of mast cell activation involved in immune response (GO:0033006)2.95125900
79positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.93264996
80regulation of type 2 immune response (GO:0002828)2.93132875
81regulation of gamma-delta T cell activation (GO:0046643)2.92151779
82response to peptidoglycan (GO:0032494)2.92087234
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91836458
84regulation of T-helper 1 type immune response (GO:0002825)2.90640925
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89724706
86positive regulation of mast cell activation (GO:0033005)2.88882355
87regulation of mononuclear cell migration (GO:0071675)2.88161828
88positive regulation of interleukin-12 production (GO:0032735)2.87816323
89phagocytosis, engulfment (GO:0006911)2.86756885
90cellular response to ethanol (GO:0071361)2.86069950
91B cell homeostasis (GO:0001782)2.85970301
92lymphocyte chemotaxis (GO:0048247)2.85833665
93positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.85508776
94positive regulation of toll-like receptor signaling pathway (GO:0034123)2.85447643
95regulation of gamma-delta T cell differentiation (GO:0045586)2.84661178
96NIK/NF-kappaB signaling (GO:0038061)2.84131309
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82911140
98regulation of T-helper cell differentiation (GO:0045622)2.82848960
99neutrophil activation (GO:0042119)2.82604128
100hyaluronan catabolic process (GO:0030214)2.82401611
101myeloid leukocyte activation (GO:0002274)2.82157148
102regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.82071365
103negative regulation of T cell mediated immunity (GO:0002710)2.81500297
104antigen processing and presentation of endogenous antigen (GO:0019883)2.80601404
105cellular response to interferon-gamma (GO:0071346)2.80057917
106positive regulation of T-helper 1 type immune response (GO:0002827)2.80014483
107regulation of mast cell activation (GO:0033003)2.79221419
108regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.78058271
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.77659953
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77659953
111regulation of chemokine biosynthetic process (GO:0045073)2.76520733
112regulation of interleukin-8 biosynthetic process (GO:0045414)2.76353163
113positive regulation of mast cell activation involved in immune response (GO:0033008)2.75875852
114positive regulation of mast cell degranulation (GO:0043306)2.75875852
115regulation of B cell differentiation (GO:0045577)2.75660516
116positive regulation of T-helper cell differentiation (GO:0045624)2.73991998
117kynurenine metabolic process (GO:0070189)2.73775890
118regulation of inflammatory response to antigenic stimulus (GO:0002861)2.73687714
119granulocyte activation (GO:0036230)2.72908400
120positive regulation of defense response to virus by host (GO:0002230)2.72894025
121modulation of growth of symbiont involved in interaction with host (GO:0044144)2.72679075
122regulation of growth of symbiont in host (GO:0044126)2.72679075
123negative regulation of growth of symbiont in host (GO:0044130)2.72679075
124negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.72679075
125positive regulation of interferon-beta production (GO:0032728)2.71407142
126B cell receptor signaling pathway (GO:0050853)2.68701519
127germinal center formation (GO:0002467)2.68694649
128regulation of lymphocyte chemotaxis (GO:1901623)2.68472160
129response to interferon-gamma (GO:0034341)2.67968479
130regulation of antigen processing and presentation (GO:0002577)2.67159816
131positive regulation of macrophage differentiation (GO:0045651)2.65583666
132regulation of interleukin-12 biosynthetic process (GO:0045075)2.63125807
133positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62996401
134negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.62710897
135regulation of podosome assembly (GO:0071801)2.62513932
136polyketide metabolic process (GO:0030638)2.62251056
137doxorubicin metabolic process (GO:0044598)2.62251056
138daunorubicin metabolic process (GO:0044597)2.62251056
139regulation of leukocyte degranulation (GO:0043300)2.62204286
140leukocyte cell-cell adhesion (GO:0007159)2.61620158
141myeloid dendritic cell differentiation (GO:0043011)2.61462818
142response to laminar fluid shear stress (GO:0034616)2.60778484
143cellular response to molecule of bacterial origin (GO:0071219)2.60777747
144cellular response to lipopolysaccharide (GO:0071222)2.59561815
145respiratory burst (GO:0045730)2.58478933
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57311175
147regulation of tolerance induction (GO:0002643)2.56333960
148regulation of granulocyte differentiation (GO:0030852)2.54373052
149negative thymic T cell selection (GO:0045060)2.54150243
150regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53548275
151cytokine secretion (GO:0050663)2.52049483
152interferon-gamma production (GO:0032609)2.51245233
153positive T cell selection (GO:0043368)2.50114741
154positive regulation of tumor necrosis factor production (GO:0032760)2.48867476
155production of molecular mediator involved in inflammatory response (GO:0002532)2.48568061
156positive regulation of leukocyte degranulation (GO:0043302)2.47713651
157regulation of interleukin-2 biosynthetic process (GO:0045076)2.47177373
158glycosphingolipid catabolic process (GO:0046479)2.47000439
159regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.46760988
160negative T cell selection (GO:0043383)2.44965863
161modulation by symbiont of host cellular process (GO:0044068)2.44718659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.68193552
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88120050
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.68284607
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16527383
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.11868316
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.04409573
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.95094000
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27974275
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12546007
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.03493721
11* SCL_19346495_ChIP-Seq_HPC-7_Human2.82232793
12RUNX_20019798_ChIP-Seq_JUKART_Human2.80903493
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74020831
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.56794915
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.53411182
16GATA1_22025678_ChIP-Seq_K562_Human2.49379812
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41624925
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.36954311
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32055987
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.25982007
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20621667
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14402944
23SPI1_23127762_ChIP-Seq_K562_Human2.07219972
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97729295
25* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96038524
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89922934
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79000333
28* MYB_26560356_Chip-Seq_TH2_Human1.78957264
29SPI1_23547873_ChIP-Seq_NB4_Human1.75699355
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75185149
31* VDR_24787735_ChIP-Seq_THP-1_Human1.72863553
32PU_27001747_Chip-Seq_BMDM_Mouse1.72674328
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71067508
34MAF_26560356_Chip-Seq_TH1_Human1.68864230
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.68623861
36* RUNX1_22412390_ChIP-Seq_EML_Mouse1.65972655
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65201325
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63117865
39* VDR_24763502_ChIP-Seq_THP-1_Human1.57821724
40GATA1_19941826_ChIP-Seq_K562_Human1.52741814
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.52517504
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51301903
43* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50891065
44* VDR_21846776_ChIP-Seq_THP-1_Human1.50059421
45SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48785967
46* GATA1_19941827_ChIP-Seq_MEL_Mouse1.48437534
47* MYB_26560356_Chip-Seq_TH1_Human1.48167155
48TCF7_22412390_ChIP-Seq_EML_Mouse1.41263969
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41247964
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38290758
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37160582
52* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36146458
53GATA2_19941826_ChIP-Seq_K562_Human1.33716473
54* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32452544
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31703186
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24413549
57MYC_22102868_ChIP-Seq_BL_Human1.20860674
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20267246
59* UTX_26944678_Chip-Seq_JUKART_Human1.19266909
60GATA3_27048872_Chip-Seq_THYMUS_Human1.14935669
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14463252
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14023225
63* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13472017
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11577322
65* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10221505
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08347783
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.03618067
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03055905
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02084808
70KDM2B_26808549_Chip-Seq_DND41_Human1.00570242
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99329975
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99293366
73STAT1_20625510_ChIP-Seq_HELA_Human0.97388665
74GATA3_26560356_Chip-Seq_TH2_Human0.96306336
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95419047
76DROSHA_22980978_ChIP-Seq_HELA_Human0.93276132
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93207630
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92588065
79EGR1_19032775_ChIP-ChIP_M12_Human0.92525055
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92342423
81SMRT_27268052_Chip-Seq_Bcells_Human0.91673765
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89642193
83GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89403101
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.88615146
85SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88332140
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86722843
87GBX2_23144817_ChIP-Seq_PC3_Human0.86509407
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.84976856
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.84710282
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.84508398
91TP53_16413492_ChIP-PET_HCT116_Human0.82811026
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.82608251
93MAF_26560356_Chip-Seq_TH2_Human0.82212012
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80618518
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80599749
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80174845
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80054332
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79989221
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79107816
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78792531
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78671064
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77630039
103CJUN_26792858_Chip-Seq_BT549_Human0.77139967
104REST_21632747_ChIP-Seq_MESCs_Mouse0.74817123
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74516682
106CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72412516
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71153013
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71153013
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70695932
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70577625
111PU1_27457419_Chip-Seq_LIVER_Mouse0.70083144
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.69773066
113GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68867623
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.68335765
115PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68247986
116AHR_22903824_ChIP-Seq_MCF-7_Human0.67995226
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67329460
118ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67224051
119CMYC_18555785_Chip-Seq_ESCs_Mouse0.66738087
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66536126
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.66527771
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.66024964
123* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.65414024
124SUZ12_18555785_Chip-Seq_ESCs_Mouse0.64710884
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.64256907
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.61936004
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.60980773
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.60827837
129* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.60739056
130SMAD1_18555785_Chip-Seq_ESCs_Mouse0.60063378
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.59836640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.05007231
2MP0001835_abnormal_antigen_presentation3.42576544
3MP0006082_CNS_inflammation3.28392332
4MP0005671_abnormal_response_to3.18553072
5MP0003436_decreased_susceptibility_to2.88917125
6* MP0002419_abnormal_innate_immunity2.87518353
7MP0003303_peritoneal_inflammation2.81240989
8MP0003172_abnormal_lysosome_physiology2.80489566
9MP0003191_abnormal_cellular_cholesterol2.77390130
10MP0005464_abnormal_platelet_physiology2.70097104
11MP0005000_abnormal_immune_tolerance2.67737274
12MP0001790_abnormal_immune_system2.66815213
13MP0005387_immune_system_phenotype2.66815213
14MP0003300_gastrointestinal_ulcer2.59171856
15MP0001800_abnormal_humoral_immune2.56640185
16MP0002148_abnormal_hypersensitivity_rea2.51395784
17* MP0002452_abnormal_antigen_presenting2.48128824
18* MP0002723_abnormal_immune_serum2.41088932
19MP0005025_abnormal_response_to2.37016021
20* MP0001819_abnormal_immune_cell2.22282544
21* MP0002420_abnormal_adaptive_immunity2.21761060
22MP0000685_abnormal_immune_system2.18481448
23MP0000569_abnormal_digit_pigmentation2.17982334
24MP0003724_increased_susceptibility_to2.06212787
25MP0003690_abnormal_glial_cell2.05829881
26MP0009785_altered_susceptibility_to2.00709782
27MP0004510_myositis1.99024524
28MP0000465_gastrointestinal_hemorrhage1.96167883
29MP0002405_respiratory_system_inflammati1.92897307
30MP0003045_fibrosis1.82595691
31* MP0001533_abnormal_skeleton_physiology1.80880044
32MP0003763_abnormal_thymus_physiology1.80246478
33MP0009840_abnormal_foam_cell1.77091671
34MP0003195_calcinosis1.70451387
35MP0005310_abnormal_salivary_gland1.68945261
36MP0001853_heart_inflammation1.67548625
37MP0002398_abnormal_bone_marrow1.66212276
38* MP0000716_abnormal_immune_system1.65537776
39MP0001873_stomach_inflammation1.64033599
40MP0001501_abnormal_sleep_pattern1.63728312
41MP0004947_skin_inflammation1.63641702
42MP0002396_abnormal_hematopoietic_system1.61759852
43* MP0001845_abnormal_inflammatory_respons1.60910762
44MP0003183_abnormal_peptide_metabolism1.60672628
45MP0000343_altered_response_to1.58726353
46MP0005174_abnormal_tail_pigmentation1.57371741
47MP0009333_abnormal_splenocyte_physiolog1.56100278
48MP0002998_abnormal_bone_remodeling1.55838837
49MP0010155_abnormal_intestine_physiology1.54852603
50MP0002139_abnormal_hepatobiliary_system1.53092363
51MP0000689_abnormal_spleen_morphology1.51508700
52MP0000372_irregular_coat_pigmentation1.50411695
53MP0001851_eye_inflammation1.45371387
54MP0002722_abnormal_immune_system1.44708500
55MP0008469_abnormal_protein_level1.42164026
56MP0003075_altered_response_to1.41796040
57MP0002332_abnormal_exercise_endurance1.41753427
58MP0002166_altered_tumor_susceptibility1.41640269
59MP0002933_joint_inflammation1.40754804
60MP0002254_reproductive_system_inflammat1.37499111
61MP0009278_abnormal_bone_marrow1.34494136
62* MP0002429_abnormal_blood_cell1.32651324
63MP0003448_altered_tumor_morphology1.31783590
64MP0003566_abnormal_cell_adhesion1.31026871
65MP0008004_abnormal_stomach_pH1.27704244
66MP0003329_amyloid_beta_deposits1.23802829
67MP0003136_yellow_coat_color1.22913070
68MP0000920_abnormal_myelination1.22347472
69MP0002006_tumorigenesis1.21813106
70MP0000015_abnormal_ear_pigmentation1.19040916
71MP0005167_abnormal_blood-brain_barrier1.18853789
72MP0009764_decreased_sensitivity_to1.11756960
73MP0004808_abnormal_hematopoietic_stem1.11143668
74MP0003646_muscle_fatigue1.02956151
75MP0005166_decreased_susceptibility_to1.01140548
76MP0005397_hematopoietic_system_phenotyp1.01044134
77MP0001545_abnormal_hematopoietic_system1.01044134
78MP0000703_abnormal_thymus_morphology1.00885042
79MP0000604_amyloidosis1.00052776
80MP0005451_abnormal_body_composition0.98272224
81MP0003806_abnormal_nucleotide_metabolis0.98227015
82MP0000858_altered_metastatic_potential0.95577014
83MP0002095_abnormal_skin_pigmentation0.94117903
84MP0003828_pulmonary_edema0.93487848
85MP0002064_seizures0.93481347
86MP0006054_spinal_hemorrhage0.89397939
87MP0003633_abnormal_nervous_system0.88974804
88MP0000249_abnormal_blood_vessel0.88597804
89MP0003279_aneurysm0.87505715
90MP0009763_increased_sensitivity_to0.86641846
91* MP0005390_skeleton_phenotype0.86302389
92MP0005670_abnormal_white_adipose0.86301165
93MP0010307_abnormal_tumor_latency0.84147009
94MP0003453_abnormal_keratinocyte_physiol0.83963533
95MP0003866_abnormal_defecation0.83452997
96MP0005171_absent_coat_pigmentation0.83169016
97MP0005257_abnormal_intraocular_pressure0.81105940
98MP0005023_abnormal_wound_healing0.78630213
99* MP0003795_abnormal_bone_structure0.76087688
100MP0003656_abnormal_erythrocyte_physiolo0.76050008
101MP0002277_abnormal_respiratory_mucosa0.75869961
102MP0005075_abnormal_melanosome_morpholog0.74592018
103MP0009745_abnormal_behavioral_response0.73792102
104MP0000490_abnormal_crypts_of0.73635373
105MP0005535_abnormal_body_temperature0.72827913
106MP0005647_abnormal_sex_gland0.72523041
107MP0002138_abnormal_hepatobiliary_system0.70654317
108MP0001915_intracranial_hemorrhage0.70103832
109MP0009765_abnormal_xenobiotic_induced0.69393877
110MP0004883_abnormal_blood_vessel0.69200001
111MP0001986_abnormal_taste_sensitivity0.68456651
112MP0008438_abnormal_cutaneous_collagen0.67788130
113MP0009046_muscle_twitch0.67176387
114MP0004381_abnormal_hair_follicle0.67050718
115MP0003091_abnormal_cell_migration0.66016023
116MP0003634_abnormal_glial_cell0.65818530
117MP0003631_nervous_system_phenotype0.65812238
118MP0003632_abnormal_nervous_system0.65082282
119MP0001968_abnormal_touch/_nociception0.64085376
120MP0000767_abnormal_smooth_muscle0.63972394
121MP0008874_decreased_physiological_sensi0.63376375
122MP0004885_abnormal_endolymph0.63271188
123MP0001324_abnormal_eye_pigmentation0.62825561
124MP0002693_abnormal_pancreas_physiology0.62705092
125MP0000371_diluted_coat_color0.62681997
126MP0002136_abnormal_kidney_physiology0.62177457
127MP0001663_abnormal_digestive_system0.61892036
128MP0005164_abnormal_response_to0.61550922
129MP0005076_abnormal_cell_differentiation0.57402961

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)6.21208768
2Recurrent abscess formation (HP:0002722)5.50382505
3Recurrent bacterial skin infections (HP:0005406)5.04043454
4Eczematoid dermatitis (HP:0000976)4.76908085
5Increased cerebral lipofuscin (HP:0011813)4.66590093
6Glomerulonephritis (HP:0000099)4.48075403
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.38132029
8Myositis (HP:0100614)4.06232216
9Dysostosis multiplex (HP:0000943)3.95453548
10Abnormality of liposaccharide metabolism (HP:0010968)3.91076102
11Abnormality of glycosphingolipid metabolism (HP:0004343)3.91076102
12Abnormality of glycolipid metabolism (HP:0010969)3.91076102
13Vacuolated lymphocytes (HP:0001922)3.84601594
14Neurofibrillary tangles (HP:0002185)3.39432761
15Orchitis (HP:0100796)3.38377870
16Optic neuritis (HP:0100653)3.35663254
17Retrobulbar optic neuritis (HP:0100654)3.35663254
18Pustule (HP:0200039)3.33113978
19Abnormality of macrophages (HP:0004311)3.31852907
20Keratoconjunctivitis (HP:0001096)3.29596182
21Recurrent skin infections (HP:0001581)3.23975041
22Recurrent gram-negative bacterial infections (HP:0005420)3.22278301
23Recurrent fungal infections (HP:0002841)3.21297444
24Petechiae (HP:0000967)3.17657831
25Complement deficiency (HP:0004431)3.15116604
26Elevated erythrocyte sedimentation rate (HP:0003565)3.00710235
27Spontaneous hematomas (HP:0007420)2.94184953
28Mediastinal lymphadenopathy (HP:0100721)2.92121344
29Axonal loss (HP:0003447)2.90922651
30Prolonged bleeding time (HP:0003010)2.83883705
31Prostate neoplasm (HP:0100787)2.81468512
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80798192
33Abnormality of polysaccharide metabolism (HP:0011012)2.80798192
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80798192
35Abnormality of T cell number (HP:0011839)2.80534949
36Obstructive lung disease (HP:0006536)2.80285121
37Chronic obstructive pulmonary disease (HP:0006510)2.80285121
38T lymphocytopenia (HP:0005403)2.79935077
39Abnormality of complement system (HP:0005339)2.79004710
40Cerebral aneurysm (HP:0004944)2.78278315
41Urinary glycosaminoglycan excretion (HP:0003541)2.77533095
42Mucopolysacchariduria (HP:0008155)2.77533095
43Global brain atrophy (HP:0002283)2.76302744
44Gangrene (HP:0100758)2.75887512
45Hematochezia (HP:0002573)2.67724769
46Disinhibition (HP:0000734)2.65605350
47Recurrent viral infections (HP:0004429)2.63256646
48Colitis (HP:0002583)2.62737986
49Albinism (HP:0001022)2.62384050
50Autoimmune hemolytic anemia (HP:0001890)2.61423732
51Stomatitis (HP:0010280)2.60731866
52Chronic otitis media (HP:0000389)2.60648103
53Gastrointestinal infarctions (HP:0005244)2.60528492
54Arterial tortuosity (HP:0005116)2.60403636
55Gingivitis (HP:0000230)2.59478620
56Ocular albinism (HP:0001107)2.54957051
57Agnosia (HP:0010524)2.54483275
58Pulmonary infiltrates (HP:0002113)2.54362079
59Nephritis (HP:0000123)2.54154904
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.53926085
61Increased IgM level (HP:0003496)2.53452610
62Bilateral sensorineural hearing impairment (HP:0008619)2.52848692
63Periodontitis (HP:0000704)2.51883354
64Myocardial infarction (HP:0001658)2.51837133
65Gingival bleeding (HP:0000225)2.50737266
66Inflammation of the large intestine (HP:0002037)2.48405185
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.47766081
68Polyneuropathy (HP:0001271)2.46834387
69Encephalitis (HP:0002383)2.46474465
70Retinal atrophy (HP:0001105)2.45052971
71Segmental peripheral demyelination/remyelination (HP:0003481)2.42474559
72Chronic mucocutaneous candidiasis (HP:0002728)2.40685641
73Recurrent cutaneous fungal infections (HP:0011370)2.40685641
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.38143969
75Osteolytic defects of the hand bones (HP:0009699)2.38143969
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37768040
77Autoimmune thrombocytopenia (HP:0001973)2.36945747
78Pulmonary embolism (HP:0002204)2.36587334
79Neuronal loss in central nervous system (HP:0002529)2.31725327
80Vasculitis (HP:0002633)2.31454361
81Arterial thrombosis (HP:0004420)2.31417052
82Thick nail (HP:0001805)2.30262695
83Joint swelling (HP:0001386)2.29187936
84Vertigo (HP:0002321)2.28847385
85Apathy (HP:0000741)2.27499664
86Vascular tortuosity (HP:0004948)2.26722213
87Diminished motivation (HP:0000745)2.25481789
88Amyloidosis (HP:0011034)2.24762993
89Leukocytosis (HP:0001974)2.24434332
90Hepatosplenomegaly (HP:0001433)2.23723703
91Purpura (HP:0000979)2.23415453
92Cerebral inclusion bodies (HP:0100314)2.23097695
93Cheilitis (HP:0100825)2.22532219
94Aortic aneurysm (HP:0004942)2.22413359
95Epistaxis (HP:0000421)2.21735847
96Peripheral demyelination (HP:0011096)2.21450430
97Gastrointestinal inflammation (HP:0004386)2.21376818
98Eosinophilia (HP:0001880)2.20986998
99Inappropriate behavior (HP:0000719)2.20033977
100Meningitis (HP:0001287)2.19845074
101Chronic diarrhea (HP:0002028)2.19246215
102Spondylolisthesis (HP:0003302)2.18282157
103Iris hypopigmentation (HP:0007730)2.17822077
104Abnormality of the periventricular white matter (HP:0002518)2.17183597
105Supranuclear gaze palsy (HP:0000605)2.16007948
106IgM deficiency (HP:0002850)2.15698094
107Tetraparesis (HP:0002273)2.15538275
108Abnormality of the pleura (HP:0002103)2.15343362
109Abnormality of the prostate (HP:0008775)2.14320876
110Stomach cancer (HP:0012126)2.13552173
111Memory impairment (HP:0002354)2.11444353
112Anorexia (HP:0002039)2.10514292
113Parakeratosis (HP:0001036)2.06418951
114Keratoconjunctivitis sicca (HP:0001097)2.06233694
115Increased CSF protein (HP:0002922)2.04212437
116Abnormal platelet function (HP:0011869)2.02445231
117Impaired platelet aggregation (HP:0003540)2.02445231
118Disproportionate tall stature (HP:0001519)2.01562870
119Basal ganglia calcification (HP:0002135)2.01288363
120Hemoptysis (HP:0002105)1.99893124
121Urethral obstruction (HP:0000796)1.99014901
122Thoracic kyphosis (HP:0002942)1.98876141
123IgG deficiency (HP:0004315)1.98532760
124Abnormality of T cells (HP:0002843)1.96283938
125Bone pain (HP:0002653)1.96189482
126Episodic fever (HP:0001954)1.95059701
127Chest pain (HP:0100749)1.94850513
128Progressive neurologic deterioration (HP:0002344)1.94491301
129Abnormality of B cell number (HP:0010975)1.94335214
130Increased serum ferritin (HP:0003281)1.94248174
131Loss of speech (HP:0002371)1.93311619
132Abnormality of eosinophils (HP:0001879)1.92849977
133Cellulitis (HP:0100658)1.90195264
134Urticaria (HP:0001025)1.89458476
135Abnormality of binocular vision (HP:0011514)1.88865865
136Diplopia (HP:0000651)1.88865865
137Alopecia of scalp (HP:0002293)1.88734639
138Mutism (HP:0002300)1.87085328
139Clumsiness (HP:0002312)1.86559267
140Hypergammaglobulinemia (HP:0010702)1.86182233
141Abnormality of the endocardium (HP:0004306)1.84213047
142Acne (HP:0001061)1.82205956
143Nuclear cataract (HP:0100018)1.80310605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.39955109
2TXK4.37771610
3MAP4K13.51027712
4TYK23.01866899
5BLK2.43773286
6BMPR22.40855744
7IRAK32.35514832
8CSF1R2.32284529
9TAOK32.20528975
10TBK12.14427309
11STK102.14284136
12JAK12.08755697
13MAP3K142.04003387
14ZAP701.99959195
15IRAK41.98342591
16KIT1.97157169
17RIPK41.91597324
18ITK1.87073756
19IKBKE1.79315983
20DDR21.76980054
21EPHB11.73557832
22MAPK151.72262344
23SIK21.70731529
24DAPK21.69550301
25HCK1.65974263
26CAMK1D1.60530848
27MARK31.58745815
28GRK71.58150244
29FRK1.57961687
30IKBKB1.56968051
31JAK31.55311313
32SIK31.53425495
33ACVR1B1.48403220
34SIK11.47451857
35LCK1.43499809
36CSK1.43103814
37TAOK21.39752370
38EEF2K1.36227102
39MAP3K111.32942834
40TYRO31.26636906
41CLK11.26084165
42TEC1.24678475
43FES1.24270469
44SYK1.19381347
45JAK21.17652633
46CAMK1G1.16512150
47BTK1.14340755
48LYN1.13924101
49MAP3K31.08755504
50MATK1.05348083
51NEK91.03286459
52FGFR41.01428423
53MAP3K130.99108801
54FGFR30.98777586
55IRAK20.98560012
56CDC42BPA0.98267196
57MOS0.97474711
58CDK60.97183789
59TRPM70.96352769
60PAK40.92237484
61MAP2K60.90216934
62PIM10.88257080
63CHUK0.88104900
64MAP3K100.87942087
65TAOK10.87084668
66FGR0.81835487
67ERN10.81597324
68MAP2K30.80749395
69PTK60.79179072
70MAPK120.75865319
71DMPK0.75039673
72MAP3K10.73954238
73MAPK70.70266416
74PINK10.69082666
75BMX0.68867428
76CDK120.66312167
77YES10.65516917
78NME20.64384168
79PIM20.64038205
80PRPF4B0.63623146
81PRKAA20.62947748
82RIPK10.60935748
83IGF1R0.60367094
84STK40.57703309
85SGK30.56922979
86GSK3A0.56064656
87MAPKAPK20.54835918
88MST40.54309387
89MAP3K70.54137202
90EPHA30.53927761
91EGFR0.53751556
92CDK30.51159892
93PRKCQ0.50942355
94PKN10.50089905
95PDGFRB0.49702560
96TTN0.47184104
97STK30.46805995
98EIF2AK20.46594242
99PDK20.45508912
100SGK20.45494672
101GRK60.45304492
102NTRK30.44973492
103ABL20.43477398
104PAK60.43037044
105NTRK20.42879836
106MAP3K50.42276656
107ABL10.40843951
108NUAK10.38068838
109CAMKK10.37999091
110PDK10.37780688
111INSR0.37607434
112HIPK20.37589545
113PRKCH0.37263909
114CAMK40.36528546
115FYN0.36423427
116MAPKAPK50.36273619
117PDPK10.35617060
118ADRBK20.34914419
119MAPK40.34905069
120PAK20.34891643
121DYRK1B0.34702641
122RPS6KA60.34299322
123CAMKK20.34275094
124RPS6KA40.31358077
125RPS6KC10.31001943
126RPS6KL10.31001943
127SRC0.29719671
128TNK20.29006074
129MAP4K20.28379056
130PRKCD0.27733807
131IRAK10.27156896
132INSRR0.25378314
133MAPK130.23120394
134PRKCZ0.22615305
135MARK20.20646760
136STK110.20257322
137CAMK2A0.19521160

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.48212459
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.79629637
3Other glycan degradation_Homo sapiens_hsa005112.68051764
4Osteoclast differentiation_Homo sapiens_hsa043802.59065538
5Leishmaniasis_Homo sapiens_hsa051402.42667233
6Lysosome_Homo sapiens_hsa041422.29627217
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.27673058
8Type I diabetes mellitus_Homo sapiens_hsa049402.23117968
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20770842
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.00235388
11Measles_Homo sapiens_hsa051621.94724250
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.94533486
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.85525467
14B cell receptor signaling pathway_Homo sapiens_hsa046621.83760457
15Hematopoietic cell lineage_Homo sapiens_hsa046401.82722361
16Pertussis_Homo sapiens_hsa051331.73282432
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.71645620
18Tuberculosis_Homo sapiens_hsa051521.66272321
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64283585
20Primary immunodeficiency_Homo sapiens_hsa053401.64176531
21Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62757587
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60083443
23Toxoplasmosis_Homo sapiens_hsa051451.57120280
24Malaria_Homo sapiens_hsa051441.56474392
25T cell receptor signaling pathway_Homo sapiens_hsa046601.46547745
26Allograft rejection_Homo sapiens_hsa053301.44896888
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40429711
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.39492544
29Asthma_Homo sapiens_hsa053101.35300956
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34476636
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34394387
32Chemokine signaling pathway_Homo sapiens_hsa040621.33024076
33Influenza A_Homo sapiens_hsa051641.31641526
34Autoimmune thyroid disease_Homo sapiens_hsa053201.28005369
35Antigen processing and presentation_Homo sapiens_hsa046121.27987320
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23908077
37Rheumatoid arthritis_Homo sapiens_hsa053231.19818490
38Collecting duct acid secretion_Homo sapiens_hsa049661.16511870
39Legionellosis_Homo sapiens_hsa051341.15670849
40Apoptosis_Homo sapiens_hsa042101.15588063
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.13667866
42TNF signaling pathway_Homo sapiens_hsa046681.10622018
43Graft-versus-host disease_Homo sapiens_hsa053321.09390746
44Hepatitis B_Homo sapiens_hsa051611.08927182
45Phagosome_Homo sapiens_hsa041451.05597397
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04171008
47Pancreatic cancer_Homo sapiens_hsa052121.03727253
48Platelet activation_Homo sapiens_hsa046111.02508377
49Complement and coagulation cascades_Homo sapiens_hsa046101.00789552
50Chronic myeloid leukemia_Homo sapiens_hsa052200.99743695
51Herpes simplex infection_Homo sapiens_hsa051680.99277800
52ABC transporters_Homo sapiens_hsa020100.99123027
53Salmonella infection_Homo sapiens_hsa051320.96276424
54Renin-angiotensin system_Homo sapiens_hsa046140.93173870
55Viral myocarditis_Homo sapiens_hsa054160.92572725
56African trypanosomiasis_Homo sapiens_hsa051430.90751414
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87858208
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87299274
59Notch signaling pathway_Homo sapiens_hsa043300.87040267
60Prion diseases_Homo sapiens_hsa050200.86091907
61Acute myeloid leukemia_Homo sapiens_hsa052210.83921959
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83600236
63Shigellosis_Homo sapiens_hsa051310.83099938
64Hepatitis C_Homo sapiens_hsa051600.82399102
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81453452
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77673318
67Endocytosis_Homo sapiens_hsa041440.75181848
68Amoebiasis_Homo sapiens_hsa051460.72163523
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72025086
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71195126
71Small cell lung cancer_Homo sapiens_hsa052220.71018514
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70421370
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.65058330
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62033815
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62012453
76Tryptophan metabolism_Homo sapiens_hsa003800.61949667
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.61895736
78Colorectal cancer_Homo sapiens_hsa052100.60716487
79Inositol phosphate metabolism_Homo sapiens_hsa005620.59133079
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53232563
81Rap1 signaling pathway_Homo sapiens_hsa040150.52202793
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52104834
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.52091824
84Synaptic vesicle cycle_Homo sapiens_hsa047210.51267991
85Sphingolipid metabolism_Homo sapiens_hsa006000.50853431
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.50399263
87Renal cell carcinoma_Homo sapiens_hsa052110.50145174
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49676317
89Morphine addiction_Homo sapiens_hsa050320.49646880
90Prolactin signaling pathway_Homo sapiens_hsa049170.47609474
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45400796
92Ether lipid metabolism_Homo sapiens_hsa005650.44522756
93Focal adhesion_Homo sapiens_hsa045100.44186943
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.43590524
95Dorso-ventral axis formation_Homo sapiens_hsa043200.43034650
96Adherens junction_Homo sapiens_hsa045200.42969479
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42917721
98HTLV-I infection_Homo sapiens_hsa051660.42915891
99ECM-receptor interaction_Homo sapiens_hsa045120.42292220
100Non-small cell lung cancer_Homo sapiens_hsa052230.41232167
101Epstein-Barr virus infection_Homo sapiens_hsa051690.40021150
102Lysine degradation_Homo sapiens_hsa003100.38648651
103Proteoglycans in cancer_Homo sapiens_hsa052050.36714357
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36625468
105VEGF signaling pathway_Homo sapiens_hsa043700.36251096
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35626481
107Caffeine metabolism_Homo sapiens_hsa002320.34989622
108MAPK signaling pathway_Homo sapiens_hsa040100.34890658
109FoxO signaling pathway_Homo sapiens_hsa040680.34822807
110Arachidonic acid metabolism_Homo sapiens_hsa005900.34588198
111Viral carcinogenesis_Homo sapiens_hsa052030.33147180
112Mineral absorption_Homo sapiens_hsa049780.32695865
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32505718
114Type II diabetes mellitus_Homo sapiens_hsa049300.31102958
115GnRH signaling pathway_Homo sapiens_hsa049120.30378516
116Renin secretion_Homo sapiens_hsa049240.29659110
117Glutamatergic synapse_Homo sapiens_hsa047240.27383789
118* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26916163
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25963070
120GABAergic synapse_Homo sapiens_hsa047270.25696137
121Salivary secretion_Homo sapiens_hsa049700.24357697
122Oxytocin signaling pathway_Homo sapiens_hsa049210.24084295
123Circadian entrainment_Homo sapiens_hsa047130.23330447
124PPAR signaling pathway_Homo sapiens_hsa033200.19042578
125Insulin resistance_Homo sapiens_hsa049310.17814995

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »