P2RX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)6.39968937
2skeletal muscle fiber development (GO:0048741)4.99686419
3regulation of relaxation of muscle (GO:1901077)4.92438917
4response to muscle activity (GO:0014850)4.85695399
5myofibril assembly (GO:0030239)4.81045868
6response to inactivity (GO:0014854)4.79740994
7myotube cell development (GO:0014904)4.65190433
8creatine metabolic process (GO:0006600)4.36280095
9actin filament-based movement (GO:0030048)4.35371603
10muscle cell fate commitment (GO:0042693)4.18863418
11neuronal action potential propagation (GO:0019227)4.08512700
12sarcomere organization (GO:0045214)4.04956199
13* muscle contraction (GO:0006936)3.92584539
14skeletal muscle tissue development (GO:0007519)3.87865553
15cardiac myofibril assembly (GO:0055003)3.86931333
16positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.84722796
17proline transport (GO:0015824)3.80509680
18behavioral response to nicotine (GO:0035095)3.80118204
19muscle fiber development (GO:0048747)3.67417107
20negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.66091760
21regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.62481110
22* muscle system process (GO:0003012)3.57354083
23neurotransmitter-gated ion channel clustering (GO:0072578)3.50906659
24cardiac muscle contraction (GO:0060048)3.50155104
25regulation of actin filament-based movement (GO:1903115)3.49724541
26regulation of skeletal muscle contraction (GO:0014819)3.46187318
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43655404
28plasma membrane repair (GO:0001778)3.42585952
29synaptic vesicle maturation (GO:0016188)3.40030324
30synaptic transmission, cholinergic (GO:0007271)3.39508895
31muscle organ development (GO:0007517)3.37312093
32regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.35622643
33cell communication by electrical coupling (GO:0010644)3.35422785
34muscle structure development (GO:0061061)3.34046484
35myotube differentiation (GO:0014902)3.31379048
36glutamate secretion (GO:0014047)3.29394310
37regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.28824651
38sarcoplasmic reticulum calcium ion transport (GO:0070296)3.28792561
39actomyosin structure organization (GO:0031032)3.28163710
40vocalization behavior (GO:0071625)3.28061030
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25202157
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24609705
43cellular potassium ion homeostasis (GO:0030007)3.23309428
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.22727802
45glycogen catabolic process (GO:0005980)3.22551582
46positive regulation of myotube differentiation (GO:0010831)3.18234885
47regulation of striated muscle contraction (GO:0006942)3.17444436
48cilium movement (GO:0003341)3.17047873
49sodium ion export (GO:0071436)3.15624524
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.13522854
51striated muscle adaptation (GO:0014888)3.11077471
52striated muscle atrophy (GO:0014891)3.10501308
53response to auditory stimulus (GO:0010996)3.08200124
54synaptic vesicle exocytosis (GO:0016079)3.03709276
55locomotory exploration behavior (GO:0035641)3.02173966
56alanine transport (GO:0032328)2.98521952
57glucan catabolic process (GO:0009251)2.97216611
58regulation of membrane repolarization (GO:0060306)2.96474140
59regulation of short-term neuronal synaptic plasticity (GO:0048172)2.94700650
60myoblast fusion (GO:0007520)2.94097090
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93812004
62striated muscle cell development (GO:0055002)2.88327123
63synaptic vesicle docking involved in exocytosis (GO:0016081)2.87773065
64regulation of beta-amyloid formation (GO:1902003)2.87314429
65negative regulation of calcium ion transmembrane transport (GO:1903170)2.87048155
66negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.87048155
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86979611
68negative regulation of protein localization to cell surface (GO:2000009)2.86840890
69glucan biosynthetic process (GO:0009250)2.85438813
70glycogen biosynthetic process (GO:0005978)2.85438813
71neurofilament cytoskeleton organization (GO:0060052)2.84221586
72regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82609907
73neuronal action potential (GO:0019228)2.82177806
74negative regulation of potassium ion transmembrane transport (GO:1901380)2.78760727
75skeletal muscle tissue regeneration (GO:0043403)2.77782377
76axoneme assembly (GO:0035082)2.76959608
77membrane depolarization during action potential (GO:0086010)2.76154220
78ubiquinone biosynthetic process (GO:0006744)2.75316712
79striated muscle tissue development (GO:0014706)2.74402760
80positive regulation of myoblast differentiation (GO:0045663)2.73326262
81regulation of synaptic vesicle exocytosis (GO:2000300)2.73227208
82actin-myosin filament sliding (GO:0033275)2.72877107
83muscle filament sliding (GO:0030049)2.72877107
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70883827
85regulation of amyloid precursor protein catabolic process (GO:1902991)2.67636516
86muscle atrophy (GO:0014889)2.67261505
87regulation of synapse structural plasticity (GO:0051823)2.66179262
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.65340513
89regulation of glutamate receptor signaling pathway (GO:1900449)2.64488104
90response to gravity (GO:0009629)2.64010407
91cellular polysaccharide catabolic process (GO:0044247)2.63121425
92cardiac muscle hypertrophy (GO:0003300)2.62944763
93regulation of sarcomere organization (GO:0060297)2.62897593
942-oxoglutarate metabolic process (GO:0006103)2.62216799
95potassium ion import (GO:0010107)2.62200523
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61402091
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.61235862
98neurotransmitter catabolic process (GO:0042135)2.61025167
99regulation of cell communication by electrical coupling (GO:0010649)2.60175164
100regulation of synaptic vesicle transport (GO:1902803)2.59985597
101cilium or flagellum-dependent cell motility (GO:0001539)2.59933368
102heart contraction (GO:0060047)2.58714366
103heart process (GO:0003015)2.58714366
104regulation of glycogen (starch) synthase activity (GO:2000465)2.57933477
105positive regulation of synapse maturation (GO:0090129)2.55905023
106cell communication involved in cardiac conduction (GO:0086065)2.55444563
107regulation of sequestering of triglyceride (GO:0010889)2.55154989
108response to activity (GO:0014823)2.55114958
109skeletal muscle contraction (GO:0003009)2.54801042
110neuromuscular synaptic transmission (GO:0007274)2.53960494
111postsynaptic membrane organization (GO:0001941)2.53770483
112negative regulation of sodium ion transport (GO:0010766)2.53273147
113regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.53023617
114striated muscle hypertrophy (GO:0014897)2.52935551
115muscle cell cellular homeostasis (GO:0046716)2.52482830
116neurotransmitter secretion (GO:0007269)2.52398660
117regulation of synapse maturation (GO:0090128)2.51355115
118relaxation of muscle (GO:0090075)2.50412583
119polysaccharide catabolic process (GO:0000272)2.49083536
120positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.48312135
121positive regulation of potassium ion transport (GO:0043268)2.47593072
122carnitine shuttle (GO:0006853)2.47039679
123regulation of acyl-CoA biosynthetic process (GO:0050812)2.47013877
124muscle cell development (GO:0055001)2.46428052
125regulation of calcium ion transmembrane transport (GO:1903169)2.46398134
126regulation of calcium ion transmembrane transporter activity (GO:1901019)2.46398134
127cellular sodium ion homeostasis (GO:0006883)2.46285075
128negative regulation of hormone metabolic process (GO:0032351)2.45843893
129negative regulation of hormone biosynthetic process (GO:0032353)2.45843893
130tricarboxylic acid cycle (GO:0006099)2.45436262
131calcium-mediated signaling using intracellular calcium source (GO:0035584)2.45426645
132ubiquinone metabolic process (GO:0006743)2.45266367
133regulation of muscle system process (GO:0090257)2.43847963
134protein localization to synapse (GO:0035418)2.43476788
135positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.43336774
136regulation of sodium ion transmembrane transporter activity (GO:2000649)2.42073740
137innervation (GO:0060384)2.41917156
138membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.40353989
139muscle tissue development (GO:0060537)2.40132627
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40015877
141response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.38706998
142neuron cell-cell adhesion (GO:0007158)2.38288674
143auditory receptor cell stereocilium organization (GO:0060088)2.38242966
144long-term synaptic potentiation (GO:0060291)2.38124134
145auditory behavior (GO:0031223)2.37906829
146regulation of sodium ion transmembrane transport (GO:1902305)2.37177476
147regulation of potassium ion transmembrane transport (GO:1901379)2.36830026
148striated muscle contraction (GO:0006941)2.35667705
149regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.33417754
150regulation of synaptic transmission, glutamatergic (GO:0051966)2.33015536
151layer formation in cerebral cortex (GO:0021819)2.32939361
152neuromuscular process controlling posture (GO:0050884)2.32291619
153regulation of neuronal synaptic plasticity (GO:0048168)2.31589761
154activation of protein kinase A activity (GO:0034199)2.29516018
155neuromuscular junction development (GO:0007528)2.29321100
156membrane repolarization (GO:0086009)2.28936675
157regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.28761515
158striatum development (GO:0021756)2.27948511
159glial cell proliferation (GO:0014009)2.25912924
160chondroitin sulfate catabolic process (GO:0030207)2.25080737
161skeletal muscle adaptation (GO:0043501)2.24978830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.80368685
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69684762
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62826223
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.48821715
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43171414
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40471234
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39535416
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39535416
9AR_21572438_ChIP-Seq_LNCaP_Human2.38698952
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36113002
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30840403
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30367179
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29265395
14VDR_22108803_ChIP-Seq_LS180_Human2.27771325
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27396224
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22612979
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.18096313
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.00797179
19GBX2_23144817_ChIP-Seq_PC3_Human2.00381346
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.00199901
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.91698344
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90645794
23DROSHA_22980978_ChIP-Seq_HELA_Human1.88917348
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.68373123
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68366843
26REST_21632747_ChIP-Seq_MESCs_Mouse1.64386132
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.59583389
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49452795
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.48737958
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.48708989
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46756972
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45298408
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43553622
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.42516317
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.42177586
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42057431
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41617682
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41195958
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38978837
40SMAD4_21799915_ChIP-Seq_A2780_Human1.38343846
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.36369177
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.35309406
43BCAT_22108803_ChIP-Seq_LS180_Human1.31143019
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30869564
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29968921
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29691369
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.29209133
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28919980
49TAF15_26573619_Chip-Seq_HEK293_Human1.27912837
50ZNF274_21170338_ChIP-Seq_K562_Hela1.27008547
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26361056
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24105119
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22882544
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21704071
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19944131
56IGF1R_20145208_ChIP-Seq_DFB_Human1.19677826
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.19473252
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19401225
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19244159
60AR_25329375_ChIP-Seq_VCAP_Human1.17179003
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16621575
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.16394978
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.15621797
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14761866
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.14668461
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13803708
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12202953
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08682129
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08203967
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08001495
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07691932
72* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07565074
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07174410
74* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07027013
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06241075
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05530608
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05241072
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05241072
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.04448378
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.04166175
81RNF2_27304074_Chip-Seq_NSC_Mouse1.02843016
82MYC_19829295_ChIP-Seq_ESCs_Human1.00866986
83P300_19829295_ChIP-Seq_ESCs_Human1.00463177
84AR_19668381_ChIP-Seq_PC3_Human0.98740777
85TP53_18474530_ChIP-ChIP_U2OS_Human0.98315513
86AHR_22903824_ChIP-Seq_MCF-7_Human0.98312115
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97811642
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.97406981
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96666564
90OCT4_20526341_ChIP-Seq_ESCs_Human0.96523168
91ER_23166858_ChIP-Seq_MCF-7_Human0.95103683
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.94734476
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94560077
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.93250780
95KDM2B_26808549_Chip-Seq_K562_Human0.92270477
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91799557
97CBP_20019798_ChIP-Seq_JUKART_Human0.91799557
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91619360
99RXR_22108803_ChIP-Seq_LS180_Human0.90676815
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.90514159
101TBX20_22328084_ChIP-Seq_HEART_Mouse0.90514159
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.90065340
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89805458
104ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89649440
105TAF2_19829295_ChIP-Seq_ESCs_Human0.88132117
106TP53_16413492_ChIP-PET_HCT116_Human0.88036249
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.87862523
108STAT3_23295773_ChIP-Seq_U87_Human0.87515762
109FUS_26573619_Chip-Seq_HEK293_Human0.87074279
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86936424
111NANOG_19829295_ChIP-Seq_ESCs_Human0.86692690
112SOX2_19829295_ChIP-Seq_ESCs_Human0.86692690
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86618629
114* TP53_23651856_ChIP-Seq_MEFs_Mouse0.86236857
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86140507
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86101602
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86008340
118TP53_22573176_ChIP-Seq_HFKS_Human0.85961040
119CLOCK_20551151_ChIP-Seq_293T_Human0.84059823
120TCF4_23295773_ChIP-Seq_U87_Human0.83878676
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83324804
122SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83106380
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82958996
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82376958
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.82145014
126CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81994510
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81974545
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81842127
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.81450048
130CTCF_27219007_Chip-Seq_Bcells_Human0.81066884
131SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80870713
132CJUN_26792858_Chip-Seq_BT549_Human0.80311203
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79393554
134MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.79304628
135CRX_20693478_ChIP-Seq_RETINA_Mouse0.78870714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.72563333
2MP0000751_myopathy3.69225259
3MP0004145_abnormal_muscle_electrophysio3.39353036
4MP0000749_muscle_degeneration3.11502226
5MP0003646_muscle_fatigue2.91608863
6MP0004270_analgesia2.88852553
7MP0004858_abnormal_nervous_system2.79802670
8MP0002837_dystrophic_cardiac_calcinosis2.44950062
9MP0003635_abnormal_synaptic_transmissio2.34638255
10MP0003950_abnormal_plasma_membrane2.26737380
11MP0004130_abnormal_muscle_cell2.24838835
12MP0004036_abnormal_muscle_relaxation2.19273705
13MP0009780_abnormal_chondrocyte_physiolo2.10210338
14MP0001968_abnormal_touch/_nociception2.10115060
15MP0003880_abnormal_central_pattern2.05850560
16MP0009046_muscle_twitch2.02267967
17MP0005646_abnormal_pituitary_gland2.02083453
18MP0005423_abnormal_somatic_nervous2.01975357
19MP0002254_reproductive_system_inflammat2.00022909
20MP0000733_abnormal_muscle_development1.99813193
21MP0002909_abnormal_adrenal_gland1.98298210
22MP0001986_abnormal_taste_sensitivity1.97612339
23MP0000747_muscle_weakness1.91521304
24MP0003329_amyloid_beta_deposits1.89794510
25MP0002735_abnormal_chemical_nociception1.89249275
26MP0002734_abnormal_mechanical_nocicepti1.87190458
27MP0009745_abnormal_behavioral_response1.85928830
28MP0002064_seizures1.84121873
29MP0002736_abnormal_nociception_after1.82820808
30MP0002063_abnormal_learning/memory/cond1.74253192
31MP0008569_lethality_at_weaning1.62854691
32MP0001501_abnormal_sleep_pattern1.61303099
33MP0005330_cardiomyopathy1.60943515
34MP0005620_abnormal_muscle_contractility1.60431214
35MP0002733_abnormal_thermal_nociception1.58086108
36MP0002106_abnormal_muscle_physiology1.58002687
37MP0000759_abnormal_skeletal_muscle1.55788214
38MP0002272_abnormal_nervous_system1.54890512
39MP0000750_abnormal_muscle_regeneration1.54207530
40MP0000013_abnormal_adipose_tissue1.52478328
41MP0002572_abnormal_emotion/affect_behav1.52136393
42MP0001486_abnormal_startle_reflex1.50618627
43MP0001440_abnormal_grooming_behavior1.47845265
44MP0006036_abnormal_mitochondrial_physio1.46865272
45MP0005623_abnormal_meninges_morphology1.46189464
46MP0002067_abnormal_sensory_capabilities1.46038306
47MP0002269_muscular_atrophy1.43628438
48MP0005369_muscle_phenotype1.40379409
49MP0003690_abnormal_glial_cell1.34718995
50MP0001970_abnormal_pain_threshold1.34596022
51MP0004087_abnormal_muscle_fiber1.34002469
52MP0003136_yellow_coat_color1.31517783
53MP0004215_abnormal_myocardial_fiber1.30541596
54MP0004233_abnormal_muscle_weight1.24449624
55MP0002557_abnormal_social/conspecific_i1.23917741
56MP0002184_abnormal_innervation1.21432665
57MP0006276_abnormal_autonomic_nervous1.18838780
58MP0003011_delayed_dark_adaptation1.17915665
59MP0001984_abnormal_olfaction1.16906078
60MP0001502_abnormal_circadian_rhythm1.12991329
61MP0000372_irregular_coat_pigmentation1.12026809
62MP0003634_abnormal_glial_cell1.11107918
63MP0002876_abnormal_thyroid_physiology1.10315073
64MP0000778_abnormal_nervous_system1.10278973
65MP0002972_abnormal_cardiac_muscle1.09250084
66MP0000955_abnormal_spinal_cord1.05908202
67MP0002108_abnormal_muscle_morphology1.05612081
68MP0004084_abnormal_cardiac_muscle1.04929521
69MP0004484_altered_response_of1.03273219
70MP0009384_cardiac_valve_regurgitation1.02331312
71MP0004811_abnormal_neuron_physiology1.02116891
72MP0003633_abnormal_nervous_system1.01401134
73MP0005670_abnormal_white_adipose1.00106623
74MP0003137_abnormal_impulse_conducting0.98331505
75MP0002971_abnormal_brown_adipose0.98252734
76MP0003279_aneurysm0.95717324
77MP0000604_amyloidosis0.94137786
78MP0001348_abnormal_lacrimal_gland0.93912650
79MP0002882_abnormal_neuron_morphology0.93659513
80MP0005551_abnormal_eye_electrophysiolog0.93573848
81MP0005171_absent_coat_pigmentation0.93455310
82MP0005385_cardiovascular_system_phenoty0.92538641
83MP0002066_abnormal_motor_capabilities/c0.92504645
84MP0005386_behavior/neurological_phenoty0.92371255
85MP0004924_abnormal_behavior0.92371255
86MP0002332_abnormal_exercise_endurance0.90254481
87MP0005266_abnormal_metabolism0.90108455
88MP0005451_abnormal_body_composition0.89856308
89MP0003075_altered_response_to0.88893068
90MP0004085_abnormal_heartbeat0.87259238
91MP0004142_abnormal_muscle_tone0.86260357
92MP0008775_abnormal_heart_ventricle0.84816320
93MP0004043_abnormal_pH_regulation0.84180594
94MP0010030_abnormal_orbit_morphology0.83997643
95MP0002822_catalepsy0.83074584
96MP0001346_abnormal_lacrimal_gland0.82873405
97MP0001270_distended_abdomen0.80480034
98MP0003959_abnormal_lean_body0.80036356
99MP0002127_abnormal_cardiovascular_syste0.79064451
100MP0002653_abnormal_ependyma_morphology0.79024864
101MP0002234_abnormal_pharynx_morphology0.78904293
102MP0001661_extended_life_span0.78663733
103MP0003879_abnormal_hair_cell0.77725240
104MP0001958_emphysema0.76674165
105MP0001299_abnormal_eye_distance/0.76672513
106MP0006138_congestive_heart_failure0.74813223
107MP0002638_abnormal_pupillary_reflex0.73897797
108MP0000681_abnormal_thyroid_gland0.73761032
109MP0005253_abnormal_eye_physiology0.69920488
110MP0005666_abnormal_adipose_tissue0.69656653
111MP0004147_increased_porphyrin_level0.69569100
112MP0003631_nervous_system_phenotype0.69386225
113MP0002089_abnormal_postnatal_growth/wei0.69379008
114MP0008875_abnormal_xenobiotic_pharmacok0.69317986
115MP0010386_abnormal_urinary_bladder0.67379715
116MP0008438_abnormal_cutaneous_collagen0.66899370
117MP0004885_abnormal_endolymph0.66803422
118MP0001664_abnormal_digestion0.66290400
119MP0003183_abnormal_peptide_metabolism0.66267699
120MP0000003_abnormal_adipose_tissue0.66208006
121MP0005165_increased_susceptibility_to0.65450361
122MP0005535_abnormal_body_temperature0.65400246
123MP0003705_abnormal_hypodermis_morpholog0.65215547
124MP0006072_abnormal_retinal_apoptosis0.64962574
125MP0008877_abnormal_DNA_methylation0.64081080
126MP0001544_abnormal_cardiovascular_syste0.64004527
127MP0008872_abnormal_physiological_respon0.62153122
128MP0010630_abnormal_cardiac_muscle0.62136212

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.33970280
2Abnormal ciliary motility (HP:0012262)4.57276810
3Popliteal pterygium (HP:0009756)4.20125284
4Type 2 muscle fiber atrophy (HP:0003554)4.02186996
5Muscle hypertrophy of the lower extremities (HP:0008968)3.98602219
6Exercise-induced muscle cramps (HP:0003710)3.98013612
7Distal arthrogryposis (HP:0005684)3.93104235
8Myokymia (HP:0002411)3.88867936
9Muscle fiber inclusion bodies (HP:0100299)3.84271861
10Difficulty running (HP:0009046)3.80859711
11Malignant hyperthermia (HP:0002047)3.78619457
12Abnormal respiratory motile cilium physiology (HP:0012261)3.74853013
13Calf muscle hypertrophy (HP:0008981)3.71875280
14Calcaneovalgus deformity (HP:0001848)3.71497695
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.66946722
16Weak cry (HP:0001612)3.56998906
17Focal motor seizures (HP:0011153)3.51105519
18Muscle fiber atrophy (HP:0100295)3.49973658
19Type 1 muscle fiber predominance (HP:0003803)3.44218419
20Myoglobinuria (HP:0002913)3.39197071
21Megalencephaly (HP:0001355)3.37945796
22Hyporeflexia of lower limbs (HP:0002600)3.29039022
23Deformed tarsal bones (HP:0008119)3.27852263
24Nemaline bodies (HP:0003798)3.20819744
25Myotonia (HP:0002486)3.20069221
26Muscle stiffness (HP:0003552)3.11178912
27Abnormality of the calf musculature (HP:0001430)2.97824607
28Increased variability in muscle fiber diameter (HP:0003557)2.96074269
29Amniotic constriction ring (HP:0009775)2.84764187
30Abnormality of placental membranes (HP:0011409)2.84764187
31Back pain (HP:0003418)2.81452591
32Round ear (HP:0100830)2.78027428
33Nonprogressive disorder (HP:0003680)2.75057540
34Abnormality of skeletal muscle fiber size (HP:0012084)2.72284789
35Generalized muscle weakness (HP:0003324)2.70958542
36Rhinitis (HP:0012384)2.64139815
37Visual hallucinations (HP:0002367)2.63341282
38Muscle fiber splitting (HP:0003555)2.60794992
39Broad metatarsal (HP:0001783)2.58718474
40Myopathic facies (HP:0002058)2.55268300
41Abnormal respiratory motile cilium morphology (HP:0005938)2.53160453
42Abnormal respiratory epithelium morphology (HP:0012253)2.53160453
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52864110
44Bulbar palsy (HP:0001283)2.52420068
45Akinesia (HP:0002304)2.51991797
46Action tremor (HP:0002345)2.50648294
47Asymmetric septal hypertrophy (HP:0001670)2.47167803
48Ulnar deviation of the wrist (HP:0003049)2.44186478
49Hip contracture (HP:0003273)2.43708966
50EMG: neuropathic changes (HP:0003445)2.37498016
51EMG: myopathic abnormalities (HP:0003458)2.35104195
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.34979610
53Aplasia involving bones of the extremities (HP:0009825)2.33538116
54Aplasia involving bones of the upper limbs (HP:0009823)2.33538116
55Aplasia of the phalanges of the hand (HP:0009802)2.33538116
56Easy fatigability (HP:0003388)2.33023187
57Limb-girdle muscle atrophy (HP:0003797)2.32453314
58Mildly elevated creatine phosphokinase (HP:0008180)2.30937971
59Increased connective tissue (HP:0009025)2.27063533
60Focal seizures (HP:0007359)2.26571116
61Hyperkalemia (HP:0002153)2.25943659
62Supranuclear gaze palsy (HP:0000605)2.24005751
63Subaortic stenosis (HP:0001682)2.22416193
64Abnormality of the left ventricular outflow tract (HP:0011103)2.22416193
65Aplasia of the musculature (HP:0100854)2.19738385
66Sudden death (HP:0001699)2.19410759
67Epileptic encephalopathy (HP:0200134)2.18578851
68Respiratory insufficiency due to muscle weakness (HP:0002747)2.16939205
69Areflexia of lower limbs (HP:0002522)2.16878852
70Type II lissencephaly (HP:0007260)2.15780550
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.08881528
72Absent/shortened dynein arms (HP:0200106)2.08881528
73Atonic seizures (HP:0010819)2.07205189
74Ulnar claw (HP:0001178)2.04082782
75Rhabdomyolysis (HP:0003201)2.03255061
76Difficulty climbing stairs (HP:0003551)2.00158892
77Progressive cerebellar ataxia (HP:0002073)1.98158857
78Scapular winging (HP:0003691)1.95577324
79Thin ribs (HP:0000883)1.93881051
80Hypothermia (HP:0002045)1.93017883
81Facial diplegia (HP:0001349)1.92625974
82Bundle branch block (HP:0011710)1.91675746
83Neurofibrillary tangles (HP:0002185)1.88533524
84Generalized tonic-clonic seizures (HP:0002069)1.84657081
85Hemiplegia (HP:0002301)1.84126567
86Absent phalangeal crease (HP:0006109)1.83563793
87Anxiety (HP:0000739)1.82004506
88Narrow nasal bridge (HP:0000446)1.81310731
89Fetal akinesia sequence (HP:0001989)1.81169133
90Limited hip movement (HP:0008800)1.80486695
91Waddling gait (HP:0002515)1.79704651
92Stridor (HP:0010307)1.79348499
93Left ventricular hypertrophy (HP:0001712)1.79319894
94Lipoatrophy (HP:0100578)1.78874491
95Ankle clonus (HP:0011448)1.78630266
96Febrile seizures (HP:0002373)1.78210154
97Oligomenorrhea (HP:0000876)1.78194514
98Gowers sign (HP:0003391)1.77825932
99Abnormality of the calcaneus (HP:0008364)1.77596218
100Long clavicles (HP:0000890)1.75368601
101Dilated cardiomyopathy (HP:0001644)1.74702435
102Proximal amyotrophy (HP:0007126)1.74109298
103Abnormal finger flexion creases (HP:0006143)1.73934212
104Truncal ataxia (HP:0002078)1.73905436
105Median cleft lip (HP:0000161)1.71153114
106Neonatal respiratory distress (HP:0002643)1.70114678
107Pterygium (HP:0001059)1.69609080
108Gait imbalance (HP:0002141)1.69581266
109Hypoplastic ischia (HP:0003175)1.69090817
110Cerebral inclusion bodies (HP:0100314)1.69039519
111Prolonged QT interval (HP:0001657)1.67803756
112Abnormal atrioventricular conduction (HP:0005150)1.67376338
113Frequent falls (HP:0002359)1.64679112
114Methylmalonic acidemia (HP:0002912)1.64586309
115Delayed gross motor development (HP:0002194)1.64523988
116Lower limb muscle weakness (HP:0007340)1.63824662
117Heart block (HP:0012722)1.63486909
118Spinal rigidity (HP:0003306)1.62374990
119Neck muscle weakness (HP:0000467)1.62153647
120Fatigable weakness (HP:0003473)1.62145798
121Abnormality of the neuromuscular junction (HP:0003398)1.62145798
122Depression (HP:0000716)1.61923847
123Congenital primary aphakia (HP:0007707)1.61599346
124Torticollis (HP:0000473)1.61558777
125Ventricular fibrillation (HP:0001663)1.61031220
126Rimmed vacuoles (HP:0003805)1.60180666
127Shoulder girdle muscle weakness (HP:0003547)1.60115064
128Hypoplastic left heart (HP:0004383)1.59963101
129Abnormality of pain sensation (HP:0010832)1.59796825
130Impaired pain sensation (HP:0007328)1.59796825
131Lower limb amyotrophy (HP:0007210)1.59761047
132Urinary bladder sphincter dysfunction (HP:0002839)1.59411875
133Abnormal eating behavior (HP:0100738)1.58788026
134Hemiparesis (HP:0001269)1.58619507
135Pheochromocytoma (HP:0002666)1.58382021
136Distal lower limb muscle weakness (HP:0009053)1.58303051
137Muscular dystrophy (HP:0003560)1.57978220
138Depressed nasal tip (HP:0000437)1.57247658
139Progressive inability to walk (HP:0002505)1.57086641
140Abnormality of the shoulder girdle musculature (HP:0001435)1.56334958
141Slender build (HP:0001533)1.56115004
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55358134
143Large for gestational age (HP:0001520)1.54957624
144Anterior segment dysgenesis (HP:0007700)1.54602483
145Limb-girdle muscle weakness (HP:0003325)1.53882970
146Abnormality of the ischium (HP:0003174)1.50693304
147Ventricular arrhythmia (HP:0004308)1.49094084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.56567845
2PHKG24.47480213
3PHKG14.47480213
4CASK2.95795377
5NTRK32.50083571
6TTN2.28402349
7MAPK151.96596853
8NTRK21.94049410
9MAP2K41.90832474
10EPHA41.90110796
11OBSCN1.87051848
12MINK11.84980691
13MUSK1.83372936
14SIK11.72390085
15TRIB31.71953320
16PDK31.70762760
17PDK41.70762760
18MAP3K91.70269187
19MAP3K121.65674682
20MAPKAPK31.62177557
21PRKD31.56698110
22MOS1.56420236
23PINK11.52892624
24INSRR1.49058293
25MAP3K41.48680990
26CAMKK21.44374898
27PNCK1.42161583
28CCNB11.37543667
29MAP2K71.35655075
30BCKDK1.32097994
31WNK41.29498937
32SGK21.26203567
33MAP3K21.22942523
34DAPK21.22275423
35MARK11.22095851
36GRK11.18618290
37DMPK1.17061083
38CAMKK11.16541527
39MAP3K71.12696881
40SGK2231.09024783
41SGK4941.09024783
42KSR21.08526307
43SGK31.08173741
44PAK31.03641778
45FER1.02363317
46PAK61.01570699
47SIK20.98800722
48NTRK10.98583714
49PTK2B0.97581592
50MAPK130.96290312
51PIK3CG0.95296981
52FRK0.94373427
53PDK20.93130893
54RET0.92079580
55CDK190.91174903
56LATS20.86199765
57LIMK10.82920172
58CDK50.82229749
59CAMK2B0.81799675
60TRPM70.81673083
61MAPKAPK50.78808427
62NME10.78201929
63PRKCH0.78113427
64MAPK120.73934408
65PKN10.73649624
66NEK10.73143406
67MAP3K130.71420965
68MAP2K10.70677358
69ROCK20.70084708
70RPS6KA20.69731581
71ROCK10.68235726
72ADRBK20.67436502
73PIK3CA0.65391750
74MYLK0.64639541
75PRKCG0.64253992
76MARK20.63063871
77OXSR10.62181217
78MAP2K30.62080324
79ADRBK10.61197187
80MAP2K60.60588438
81STK390.60219424
82AKT20.59925408
83GRK50.57698796
84CAMK2A0.57429781
85CAMK10.56652520
86PRKG10.54939127
87STK110.50171127
88MET0.50157213
89DYRK1B0.49771150
90CAMK2G0.49652719
91ARAF0.48009325
92PDPK10.47475481
93MAPK110.47283714
94PDK10.46370118
95FGR0.46198397
96UHMK10.46080633
97PRKCE0.45855501
98CAMK2D0.45592254
99EPHB10.45591045
100SGK10.45367263
101DDR20.45245780
102CAMK1G0.44454530
103PAK20.44248624
104MAP3K10.42955754
105PRPF4B0.42125966
106ERBB30.42080770
107STK380.41862133
108MAP2K20.40623061
109PDGFRA0.39761396
110CAMK40.39605272
111PRKACB0.38791876
112SIK30.38096554
113PTK20.37322982
114WNK10.37308833
115TYRO30.36876538
116MAPK70.36599339
117MAPK40.36467960
118RPS6KA30.35738248
119MAP4K20.35226525
120TNIK0.35082657
121LRRK20.34759398
122PLK20.34346197
123CDC42BPA0.34150785
124PKN20.34028427
125NEK90.33666675
126PRKAA10.31331643
127KSR10.30971615
128PRKACA0.30945690
129PRKAA20.30887768
130ILK0.30528889
131PRKCA0.28831854
132CDK11A0.24977247
133WNK30.24940869
134BMPR1B0.24469001
135FLT30.23706414
136CDK150.23167003
137CDK80.21382909
138PRKACG0.20520291
139CSNK1G20.20332836
140CSNK1D0.20297471
141CDK180.17478219

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23749853
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.18228410
3Synaptic vesicle cycle_Homo sapiens_hsa047212.05118100
4Phototransduction_Homo sapiens_hsa047441.96067572
5Propanoate metabolism_Homo sapiens_hsa006401.88299748
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76176787
7Nicotine addiction_Homo sapiens_hsa050331.74718051
8Olfactory transduction_Homo sapiens_hsa047401.73993178
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73297306
10Gastric acid secretion_Homo sapiens_hsa049711.72134085
11Circadian entrainment_Homo sapiens_hsa047131.71333649
12Circadian rhythm_Homo sapiens_hsa047101.64661503
13Arginine and proline metabolism_Homo sapiens_hsa003301.63181707
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60867326
15Insulin secretion_Homo sapiens_hsa049111.57957086
16Cardiac muscle contraction_Homo sapiens_hsa042601.57519370
17GABAergic synapse_Homo sapiens_hsa047271.56650776
18Fatty acid biosynthesis_Homo sapiens_hsa000611.52937037
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47788085
20Salivary secretion_Homo sapiens_hsa049701.47666662
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47013089
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45977870
23Dilated cardiomyopathy_Homo sapiens_hsa054141.41611903
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41271969
25Renin secretion_Homo sapiens_hsa049241.40621557
26Amphetamine addiction_Homo sapiens_hsa050311.38380308
27Fatty acid metabolism_Homo sapiens_hsa012121.38296893
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38207032
29Oxytocin signaling pathway_Homo sapiens_hsa049211.37506706
30* Calcium signaling pathway_Homo sapiens_hsa040201.36669959
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35000070
32Glutamatergic synapse_Homo sapiens_hsa047241.33956221
33Long-term potentiation_Homo sapiens_hsa047201.32767620
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31423973
35Dopaminergic synapse_Homo sapiens_hsa047281.29557514
36Glucagon signaling pathway_Homo sapiens_hsa049221.23730677
37Taste transduction_Homo sapiens_hsa047421.22070063
38Cholinergic synapse_Homo sapiens_hsa047251.21432174
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18881999
40Morphine addiction_Homo sapiens_hsa050321.17256781
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14738386
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12730053
43Linoleic acid metabolism_Homo sapiens_hsa005911.10093333
44Tryptophan metabolism_Homo sapiens_hsa003801.07982653
45GnRH signaling pathway_Homo sapiens_hsa049121.07120631
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.06055983
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05407609
48Fatty acid degradation_Homo sapiens_hsa000711.02828357
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01760847
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00816328
51Insulin signaling pathway_Homo sapiens_hsa049101.00688734
52Cocaine addiction_Homo sapiens_hsa050300.98100058
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96719375
54Butanoate metabolism_Homo sapiens_hsa006500.96572194
55Huntingtons disease_Homo sapiens_hsa050160.94301726
56cAMP signaling pathway_Homo sapiens_hsa040240.94084695
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93492309
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93322599
59beta-Alanine metabolism_Homo sapiens_hsa004100.92247231
60Melanogenesis_Homo sapiens_hsa049160.91784050
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91597786
62Insulin resistance_Homo sapiens_hsa049310.88710828
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.88592672
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87970908
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.87443837
66Arginine biosynthesis_Homo sapiens_hsa002200.87270300
67Collecting duct acid secretion_Homo sapiens_hsa049660.87092724
68Peroxisome_Homo sapiens_hsa041460.86682002
69Serotonergic synapse_Homo sapiens_hsa047260.86399567
70Pyruvate metabolism_Homo sapiens_hsa006200.85093803
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84878009
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82637518
73Ovarian steroidogenesis_Homo sapiens_hsa049130.82551656
74Starch and sucrose metabolism_Homo sapiens_hsa005000.82494018
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82416046
76Alzheimers disease_Homo sapiens_hsa050100.80096516
77ErbB signaling pathway_Homo sapiens_hsa040120.78119855
78Thyroid hormone synthesis_Homo sapiens_hsa049180.77808111
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77093994
80Long-term depression_Homo sapiens_hsa047300.76486978
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75607859
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75509712
83Nitrogen metabolism_Homo sapiens_hsa009100.74808678
84Gap junction_Homo sapiens_hsa045400.74691042
85Estrogen signaling pathway_Homo sapiens_hsa049150.73730469
86ABC transporters_Homo sapiens_hsa020100.73138814
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72427162
88PPAR signaling pathway_Homo sapiens_hsa033200.72256941
89Axon guidance_Homo sapiens_hsa043600.71785291
90Carbon metabolism_Homo sapiens_hsa012000.70773227
91Oxidative phosphorylation_Homo sapiens_hsa001900.68890620
92Vibrio cholerae infection_Homo sapiens_hsa051100.68430843
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68217561
94Fatty acid elongation_Homo sapiens_hsa000620.67698271
95Type II diabetes mellitus_Homo sapiens_hsa049300.67380049
96Pancreatic secretion_Homo sapiens_hsa049720.67074524
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66883169
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66866227
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66732948
100Histidine metabolism_Homo sapiens_hsa003400.65901671
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.64773755
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64211760
103Parkinsons disease_Homo sapiens_hsa050120.63471544
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62331789
105Sulfur relay system_Homo sapiens_hsa041220.59971627
106ECM-receptor interaction_Homo sapiens_hsa045120.59377193
107* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59081754
108Glioma_Homo sapiens_hsa052140.58846491
109Regulation of autophagy_Homo sapiens_hsa041400.57926144
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57232635
111AMPK signaling pathway_Homo sapiens_hsa041520.56303233
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55062483
113MAPK signaling pathway_Homo sapiens_hsa040100.54133328
114Ether lipid metabolism_Homo sapiens_hsa005650.52974750
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.51927140
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51111065
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.50400014
118Bile secretion_Homo sapiens_hsa049760.49739251
119Fructose and mannose metabolism_Homo sapiens_hsa000510.49295455
120Sulfur metabolism_Homo sapiens_hsa009200.48428549
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48002763
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46982332
123Focal adhesion_Homo sapiens_hsa045100.46213957
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45693103
125Wnt signaling pathway_Homo sapiens_hsa043100.45667015
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44557243
127Inositol phosphate metabolism_Homo sapiens_hsa005620.44248505
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.43877780
129Choline metabolism in cancer_Homo sapiens_hsa052310.43645682
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39930039
131Tight junction_Homo sapiens_hsa045300.36931003

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