OXSM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.40506238
2L-phenylalanine catabolic process (GO:0006559)6.40506238
3aromatic amino acid family catabolic process (GO:0009074)5.87584167
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.82690232
5L-phenylalanine metabolic process (GO:0006558)5.82690232
6indole-containing compound catabolic process (GO:0042436)5.39589896
7indolalkylamine catabolic process (GO:0046218)5.39589896
8tryptophan catabolic process (GO:0006569)5.39589896
9proteasome assembly (GO:0043248)5.30385256
10tryptophan metabolic process (GO:0006568)5.07675282
11bile acid biosynthetic process (GO:0006699)4.91206792
12kynurenine metabolic process (GO:0070189)4.76430828
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.73609425
14glyoxylate metabolic process (GO:0046487)4.38700558
15cullin deneddylation (GO:0010388)4.20243514
16bile acid metabolic process (GO:0008206)4.16052429
17aromatic amino acid family metabolic process (GO:0009072)4.15879450
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.15621779
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.15621779
20high-density lipoprotein particle remodeling (GO:0034375)4.13826603
21homocysteine metabolic process (GO:0050667)4.12925338
22synapsis (GO:0007129)4.12783889
23complement activation, alternative pathway (GO:0006957)4.09211582
24amine catabolic process (GO:0009310)4.06003828
25cellular biogenic amine catabolic process (GO:0042402)4.06003828
26protein deneddylation (GO:0000338)4.03731543
27indolalkylamine metabolic process (GO:0006586)4.03453444
28peptidyl-glutamic acid carboxylation (GO:0017187)4.02501442
29protein carboxylation (GO:0018214)4.02501442
30cysteine metabolic process (GO:0006534)4.01984074
31regulation of triglyceride catabolic process (GO:0010896)4.01888998
32tyrosine metabolic process (GO:0006570)4.00373587
33regulation of fibrinolysis (GO:0051917)3.99739176
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.94989662
35urea cycle (GO:0000050)3.89461718
36urea metabolic process (GO:0019627)3.89461718
37regulation of protein activation cascade (GO:2000257)3.83977414
38ribosomal large subunit biogenesis (GO:0042273)3.83034134
39coenzyme catabolic process (GO:0009109)3.82619056
40amino-acid betaine metabolic process (GO:0006577)3.81469732
41alpha-linolenic acid metabolic process (GO:0036109)3.79666326
42regulation of cholesterol esterification (GO:0010872)3.79098532
43NAD biosynthetic process (GO:0009435)3.74391036
44fatty acid elongation (GO:0030497)3.72939275
45negative regulation of fibrinolysis (GO:0051918)3.68534129
46reverse cholesterol transport (GO:0043691)3.68052030
47nitrogen cycle metabolic process (GO:0071941)3.67433785
48acylglycerol homeostasis (GO:0055090)3.66420322
49triglyceride homeostasis (GO:0070328)3.66420322
50* short-chain fatty acid metabolic process (GO:0046459)3.65824303
51sulfur amino acid catabolic process (GO:0000098)3.63672367
52cellular ketone body metabolic process (GO:0046950)3.62599571
53phospholipid efflux (GO:0033700)3.62229175
54plasma lipoprotein particle remodeling (GO:0034369)3.61632794
55protein-lipid complex remodeling (GO:0034368)3.61632794
56macromolecular complex remodeling (GO:0034367)3.61632794
57alpha-amino acid catabolic process (GO:1901606)3.59265712
58bile acid and bile salt transport (GO:0015721)3.56419908
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55630650
60regulation of complement activation (GO:0030449)3.54075372
61glucuronate metabolic process (GO:0019585)3.51649280
62uronic acid metabolic process (GO:0006063)3.51649280
63negative regulation of lipase activity (GO:0060192)3.50111456
64purine nucleotide salvage (GO:0032261)3.49408641
65pteridine-containing compound biosynthetic process (GO:0042559)3.49280368
66ribosome biogenesis (GO:0042254)3.48814210
67aldehyde catabolic process (GO:0046185)3.48664550
68cofactor catabolic process (GO:0051187)3.45987597
69cholesterol efflux (GO:0033344)3.45738994
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45015433
71blood coagulation, intrinsic pathway (GO:0007597)3.44538027
72plasma lipoprotein particle clearance (GO:0034381)3.43988597
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42787145
74opsonization (GO:0008228)3.42530412
75drug transmembrane transport (GO:0006855)3.42429275
76tRNA aminoacylation for protein translation (GO:0006418)3.41222165
77cellular glucuronidation (GO:0052695)3.39771497
78amino acid activation (GO:0043038)3.39331332
79tRNA aminoacylation (GO:0043039)3.39331332
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37222897
81pyridine nucleotide biosynthetic process (GO:0019363)3.36890742
82nicotinamide nucleotide biosynthetic process (GO:0019359)3.36890742
83glutamate metabolic process (GO:0006536)3.34129130
84cellular amino acid catabolic process (GO:0009063)3.33177352
85very long-chain fatty acid metabolic process (GO:0000038)3.33101189
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32220169
87benzene-containing compound metabolic process (GO:0042537)3.32008183
88regulation of cellular amino acid metabolic process (GO:0006521)3.31578176
89ribonucleoprotein complex biogenesis (GO:0022613)3.31009897
90imidazole-containing compound metabolic process (GO:0052803)3.29811747
91serine family amino acid catabolic process (GO:0009071)3.28912166
92ethanol oxidation (GO:0006069)3.28170032
93mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28090052
94male meiosis I (GO:0007141)3.27773854
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27567852
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26300516
97mitochondrial respiratory chain complex I assembly (GO:0032981)3.26300516
98NADH dehydrogenase complex assembly (GO:0010257)3.26300516
99protein-cofactor linkage (GO:0018065)3.26039120
100oxidative phosphorylation (GO:0006119)3.25015153
101fibrinolysis (GO:0042730)3.23572162
102negative regulation of cholesterol transport (GO:0032375)3.23555013
103negative regulation of sterol transport (GO:0032372)3.23555013
104IMP biosynthetic process (GO:0006188)3.22623944
105low-density lipoprotein particle remodeling (GO:0034374)3.22449686
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22161579
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22099849
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22099849
109termination of RNA polymerase III transcription (GO:0006386)3.21781961
110transcription elongation from RNA polymerase III promoter (GO:0006385)3.21781961
111mitochondrial RNA metabolic process (GO:0000959)3.21104627
112branched-chain amino acid catabolic process (GO:0009083)3.20289554
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19561675
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19561675
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19561675
116folic acid-containing compound biosynthetic process (GO:0009396)3.19239944
117acetyl-CoA metabolic process (GO:0006084)3.18849788
118regulation of bile acid biosynthetic process (GO:0070857)3.18582963
119formation of translation preinitiation complex (GO:0001731)3.18377245
120rRNA modification (GO:0000154)3.16254321
121lysine catabolic process (GO:0006554)3.15641846
122lysine metabolic process (GO:0006553)3.15641846
123cellular modified amino acid catabolic process (GO:0042219)3.15191599
124phospholipid homeostasis (GO:0055091)3.14397478
125ribosomal small subunit assembly (GO:0000028)3.14245695
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.13934502
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13592096
128negative regulation of ligase activity (GO:0051352)3.13592096
129ribosome assembly (GO:0042255)3.13231880
130very-low-density lipoprotein particle assembly (GO:0034379)3.12969849
131carboxylic acid catabolic process (GO:0046395)3.11881542
132organic acid catabolic process (GO:0016054)3.11881542
133monocarboxylic acid catabolic process (GO:0072329)3.09995299
134fatty acid beta-oxidation (GO:0006635)3.09776905
135signal transduction involved in DNA damage checkpoint (GO:0072422)3.09640069
136signal transduction involved in DNA integrity checkpoint (GO:0072401)3.09640069
137inner mitochondrial membrane organization (GO:0007007)3.09540565
138ketone body metabolic process (GO:1902224)3.09351697
139fatty acid oxidation (GO:0019395)3.08874715
140fatty acid catabolic process (GO:0009062)3.08092398
141cellular component biogenesis (GO:0044085)3.07917251
142rRNA methylation (GO:0031167)3.06395807
143sterol homeostasis (GO:0055092)3.06312776
144protein activation cascade (GO:0072376)3.05940244
145pseudouridine synthesis (GO:0001522)3.04825701
146lipid oxidation (GO:0034440)3.04458706
147drug catabolic process (GO:0042737)3.03401028
148meiosis I (GO:0007127)3.02781949
149cholesterol homeostasis (GO:0042632)3.02338159
150positive regulation of ligase activity (GO:0051351)3.02250416
151signal transduction involved in cell cycle checkpoint (GO:0072395)3.01699478
152plasma lipoprotein particle assembly (GO:0034377)3.00412347
153protein complex biogenesis (GO:0070271)2.99336609
154carnitine metabolic process (GO:0009437)2.99292018
155piRNA metabolic process (GO:0034587)2.98801057
156respiratory electron transport chain (GO:0022904)2.98761419
157transcription from mitochondrial promoter (GO:0006390)2.98754336
158positive regulation of lipid catabolic process (GO:0050996)2.98207247
159tricarboxylic acid cycle (GO:0006099)2.92989774
160electron transport chain (GO:0022900)2.92180427
161nucleoside salvage (GO:0043174)2.91141992
162ubiquinone biosynthetic process (GO:0006744)2.91019323
163nucleotide salvage (GO:0043173)2.89640839
164positive regulation of triglyceride lipase activity (GO:0061365)2.89212559
165positive regulation of lipoprotein lipase activity (GO:0051006)2.89212559
166tRNA metabolic process (GO:0006399)2.85998318
167energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85759084
168ATP synthesis coupled proton transport (GO:0015986)2.85759084
169DNA catabolic process, exonucleolytic (GO:0000738)2.83597401
170branched-chain amino acid metabolic process (GO:0009081)2.78342887
171mitochondrial respiratory chain complex assembly (GO:0033108)2.78262685
172mannosylation (GO:0097502)2.77969489
173COPII vesicle coating (GO:0048208)2.77958077
174purine-containing compound salvage (GO:0043101)2.76569534
175IMP metabolic process (GO:0046040)2.76379883
176GPI anchor biosynthetic process (GO:0006506)2.76036900
177tRNA processing (GO:0008033)2.72318498
178rRNA processing (GO:0006364)2.72208265
179peptidyl-histidine modification (GO:0018202)2.69704517
180purine nucleobase biosynthetic process (GO:0009113)2.69242679
181guanosine-containing compound biosynthetic process (GO:1901070)2.69074903
182pteridine-containing compound metabolic process (GO:0042558)2.67073557
183regulation of meiosis I (GO:0060631)2.67064089
184protein targeting to mitochondrion (GO:0006626)2.66978381
185rRNA metabolic process (GO:0016072)2.64892144
186regulation of ubiquitin-protein transferase activity (GO:0051438)2.64825333
187respiratory chain complex IV assembly (GO:0008535)2.62245806
188C-terminal protein lipidation (GO:0006501)2.62094715
1897-methylguanosine mRNA capping (GO:0006370)2.59801747
190tetrahydrofolate metabolic process (GO:0046653)2.59638053
191preassembly of GPI anchor in ER membrane (GO:0016254)2.58876734
192pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.57379428
193regulation of ligase activity (GO:0051340)2.57183221
194ubiquinone metabolic process (GO:0006743)2.56337545
195CTP metabolic process (GO:0046036)2.55856405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.56937835
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97266249
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.82929520
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.37169029
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.29803260
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.94397912
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83826534
8E2F7_22180533_ChIP-Seq_HELA_Human3.59058360
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51254425
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.45683282
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.38793305
12LXR_22158963_ChIP-Seq_LIVER_Mouse3.33200068
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27610384
14ETS1_20019798_ChIP-Seq_JURKAT_Human3.26974104
15ELF1_17652178_ChIP-ChIP_JURKAT_Human3.21342400
16* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.06082788
17VDR_23849224_ChIP-Seq_CD4+_Human2.80953153
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76942317
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.74718844
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72518917
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.70324342
22GBX2_23144817_ChIP-Seq_PC3_Human2.66080101
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61711402
24* SRF_21415370_ChIP-Seq_HL-1_Mouse2.60183287
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57000259
26DCP1A_22483619_ChIP-Seq_HELA_Human2.54657750
27TAF15_26573619_Chip-Seq_HEK293_Human2.51810165
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47921683
29ELK1_19687146_ChIP-ChIP_HELA_Human2.46616321
30FOXP3_21729870_ChIP-Seq_TREG_Human2.35009356
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28339500
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.21844927
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17951868
34GABP_19822575_ChIP-Seq_HepG2_Human2.17492084
35MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16465737
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12881144
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.12142425
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09168709
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07206333
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07108353
41E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04696343
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01778809
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96301482
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95547213
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92317525
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91554517
47* TTF2_22483619_ChIP-Seq_HELA_Human1.86775773
48XRN2_22483619_ChIP-Seq_HELA_Human1.84538354
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82590757
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81076881
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77154647
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.75724978
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70336169
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67405252
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65168382
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62700946
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62080426
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.61177145
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60858137
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59680176
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.59223198
62KDM5A_27292631_Chip-Seq_BREAST_Human1.56812203
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56383537
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55439442
65* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54628177
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53543304
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53074507
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52696561
69TFEB_21752829_ChIP-Seq_HELA_Human1.51897107
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51578396
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.51212412
72P300_19829295_ChIP-Seq_ESCs_Human1.51018525
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50455459
74HTT_18923047_ChIP-ChIP_STHdh_Human1.49712039
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49580234
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.48894113
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46949240
78VDR_22108803_ChIP-Seq_LS180_Human1.45324028
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43146892
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40950588
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.40759468
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.36652827
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36420404
84ZNF263_19887448_ChIP-Seq_K562_Human1.35429218
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34565416
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33136673
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32846345
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.32650857
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32551120
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32104194
91AR_21909140_ChIP-Seq_LNCAP_Human1.32085946
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31877335
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30366374
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29210304
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.28528346
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27463333
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27117721
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26208505
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26147255
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.25685956
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.24845794
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.24808858
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24652031
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24568613
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24562093
106EZH2_22144423_ChIP-Seq_EOC_Human1.24166739
107P53_22387025_ChIP-Seq_ESCs_Mouse1.23593316
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.23402235
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22123812
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21851368
111P300_18555785_Chip-Seq_ESCs_Mouse1.21711032
112OCT4_18555785_Chip-Seq_ESCs_Mouse1.21526547
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20975903
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20975903
115EED_16625203_ChIP-ChIP_MESCs_Mouse1.19857585
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19327026
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19153292
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19138362
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.19090377
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.17714874
121ER_23166858_ChIP-Seq_MCF-7_Human1.17518595
122* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17457080
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.17108024
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16788992
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16611783
126SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16025689
127ELK1_22589737_ChIP-Seq_MCF10A_Human1.15494214
128NMYC_18555785_Chip-Seq_ESCs_Mouse1.14656057
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14345492
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13839438
131PU1_27457419_Chip-Seq_LIVER_Mouse1.12676219
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11338668
133* MYC_18940864_ChIP-ChIP_HL60_Human1.11302347
134SMAD4_21799915_ChIP-Seq_A2780_Human1.10987985
135FUS_26573619_Chip-Seq_HEK293_Human1.10959824
136RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10301419
137TP53_18474530_ChIP-ChIP_U2OS_Human1.09950092
138* TAL1_26923725_Chip-Seq_HPCs_Mouse1.09851437
139KDM2B_26808549_Chip-Seq_REH_Human1.09237747
140SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08503515
141ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08212541
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.08115307
143SOX2_18555785_Chip-Seq_ESCs_Mouse1.07068994
144* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04782512
145CIITA_25753668_ChIP-Seq_RAJI_Human1.04773722
146* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04265260
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04102804
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03359871
149* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02885483
150SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02251424
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01974788
152ZFX_18555785_Chip-Seq_ESCs_Mouse1.01773330
153MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99972530
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99952970
155AR_21572438_ChIP-Seq_LNCaP_Human0.99437521
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.98969800
157BP1_19119308_ChIP-ChIP_Hs578T_Human0.98848220
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98158847
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97743660
160EZH2_27294783_Chip-Seq_ESCs_Mouse0.96354998
161STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96173358
162EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95593835
163RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95593835
164TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95500017
165SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95294218
166MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95194505
167BCAT_22108803_ChIP-Seq_LS180_Human0.95184644
168CTCF_18555785_Chip-Seq_ESCs_Mouse0.95142810
169TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93731508
170SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93606087
171CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93194064
172IRF8_22096565_ChIP-ChIP_GC-B_Human0.91809718
173KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91177037
174GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88473131
175ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86756260
176CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86160873
177STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85901342
178ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85691105
179POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85689310
180ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84162690
181RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83057366
182PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82994632
183CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82926819
184ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82863217
185ELF5_23300383_ChIP-Seq_T47D_Human0.79951558
186TP53_22573176_ChIP-Seq_HFKS_Human0.79253578
187SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78604009
188* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77857135
189SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75875456
190ZNF274_21170338_ChIP-Seq_K562_Hela0.75857641
191CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75573784
192* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74656570
193SOX17_20123909_ChIP-Seq_XEN_Mouse0.74091158
194* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73349662

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.92872926
2MP0005360_urolithiasis6.28117298
3MP0005085_abnormal_gallbladder_physiolo5.73008922
4MP0005365_abnormal_bile_salt5.03004460
5MP0008875_abnormal_xenobiotic_pharmacok4.25594351
6MP0008058_abnormal_DNA_repair3.71147006
7MP0003252_abnormal_bile_duct3.43532901
8MP0003195_calcinosis2.96376369
9MP0008995_early_reproductive_senescence2.87602177
10MP0010329_abnormal_lipoprotein_level2.77764318
11MP0010094_abnormal_chromosome_stability2.62300112
12MP0000372_irregular_coat_pigmentation2.59646313
13MP0005332_abnormal_amino_acid2.58191945
14MP0003806_abnormal_nucleotide_metabolis2.50015259
15MP0003693_abnormal_embryo_hatching2.46359118
16MP0002138_abnormal_hepatobiliary_system2.46037748
17MP0005083_abnormal_biliary_tract2.45759784
18MP0003786_premature_aging2.45404702
19MP0002163_abnormal_gland_morphology2.45268142
20MP0005451_abnormal_body_composition2.19728536
21MP0003315_abnormal_perineum_morphology2.13135558
22MP0001666_abnormal_nutrient_absorption2.06409219
23MP0003718_maternal_effect2.05942369
24MP0004019_abnormal_vitamin_homeostasis2.00010299
25MP0004381_abnormal_hair_follicle1.97190985
26MP0002118_abnormal_lipid_homeostasis1.93814664
27MP0000013_abnormal_adipose_tissue1.88890877
28MP0003868_abnormal_feces_composition1.88377463
29MP0002009_preneoplasia1.75288191
30MP0002132_abnormal_respiratory_system1.74913804
31MP0003111_abnormal_nucleus_morphology1.74890106
32MP0003077_abnormal_cell_cycle1.74033135
33MP0004957_abnormal_blastocyst_morpholog1.73537112
34MP0009697_abnormal_copulation1.71527620
35MP0002006_tumorigenesis1.70035594
36MP0005409_darkened_coat_color1.67992385
37MP0009840_abnormal_foam_cell1.67430939
38MP0002160_abnormal_reproductive_system1.65494353
39MP0008007_abnormal_cellular_replicative1.63179000
40MP0001929_abnormal_gametogenesis1.63002718
41MP0005187_abnormal_penis_morphology1.61847395
42MP0003724_increased_susceptibility_to1.60166177
43MP0005670_abnormal_white_adipose1.57583133
44MP0002166_altered_tumor_susceptibility1.56614334
45MP0000015_abnormal_ear_pigmentation1.56450701
46MP0000609_abnormal_liver_physiology1.54390998
47MP0002210_abnormal_sex_determination1.51174472
48MP0008932_abnormal_embryonic_tissue1.49447999
49MP0002938_white_spotting1.48852240
50MP0001764_abnormal_homeostasis1.43414130
51MP0003191_abnormal_cellular_cholesterol1.43268855
52MP0003690_abnormal_glial_cell1.41150613
53MP0005379_endocrine/exocrine_gland_phen1.41034604
54MP0002876_abnormal_thyroid_physiology1.40219005
55MP0005174_abnormal_tail_pigmentation1.37190410
56MP0008877_abnormal_DNA_methylation1.37113316
57MP0002095_abnormal_skin_pigmentation1.34710237
58MP0000678_abnormal_parathyroid_gland1.33944994
59MP0005584_abnormal_enzyme/coenzyme_acti1.27996889
60MP0000358_abnormal_cell_content/1.24908868
61MP0005389_reproductive_system_phenotype1.24738682
62MP0001145_abnormal_male_reproductive1.24079313
63MP0005319_abnormal_enzyme/_coenzyme1.23779870
64MP0000653_abnormal_sex_gland1.23716581
65MP0000920_abnormal_myelination1.21538582
66MP0009764_decreased_sensitivity_to1.21463151
67MP0009379_abnormal_foot_pigmentation1.21345985
68MP0009333_abnormal_splenocyte_physiolog1.20290534
69MP0005647_abnormal_sex_gland1.20247049
70MP0005367_renal/urinary_system_phenotyp1.20138929
71MP0000516_abnormal_urinary_system1.20138929
72MP0001188_hyperpigmentation1.19499315
73MP0010307_abnormal_tumor_latency1.18620816
74MP0004233_abnormal_muscle_weight1.18565882
75MP0002254_reproductive_system_inflammat1.15456659
76MP0009643_abnormal_urine_homeostasis1.10670295
77MP0003698_abnormal_male_reproductive1.09566728
78MP0005075_abnormal_melanosome_morpholog1.09437231
79MP0008057_abnormal_DNA_replication1.08975033
80MP0005410_abnormal_fertilization1.08221538
81MP0005330_cardiomyopathy1.07816975
82MP0002928_abnormal_bile_duct1.03508369
83MP0001881_abnormal_mammary_gland1.01939081
84MP0005646_abnormal_pituitary_gland1.00708257
85MP0001119_abnormal_female_reproductive0.99944820
86MP0002837_dystrophic_cardiac_calcinosis0.97652407
87MP0004043_abnormal_pH_regulation0.96546422
88MP0005535_abnormal_body_temperature0.94996235
89MP0003136_yellow_coat_color0.94448172
90MP0004147_increased_porphyrin_level0.93459850
91MP0005220_abnormal_exocrine_pancreas0.92002615
92MP0002396_abnormal_hematopoietic_system0.90304893
93MP0008469_abnormal_protein_level0.89034505
94MP0001944_abnormal_pancreas_morphology0.89016657
95MP0009763_increased_sensitivity_to0.88926628
96MP0002971_abnormal_brown_adipose0.87478449
97MP0001501_abnormal_sleep_pattern0.87282792
98MP0000604_amyloidosis0.86757424
99MP0002822_catalepsy0.85770350
100MP0001919_abnormal_reproductive_system0.85636495
101MP0005645_abnormal_hypothalamus_physiol0.84790479
102MP0001661_extended_life_span0.84249529
103MP0005334_abnormal_fat_pad0.83967048
104MP0002693_abnormal_pancreas_physiology0.83695161
105MP0002019_abnormal_tumor_incidence0.83333674
106MP0005266_abnormal_metabolism0.83132723
107MP0005084_abnormal_gallbladder_morpholo0.82126677
108MP0005058_abnormal_lysosome_morphology0.81791008
109MP0005171_absent_coat_pigmentation0.79994710
110MP0009642_abnormal_blood_homeostasis0.78909103
111MP0000681_abnormal_thyroid_gland0.78372014
112MP0003943_abnormal_hepatobiliary_system0.78222192
113MP0003699_abnormal_female_reproductive0.78137128
114MP0003123_paternal_imprinting0.77478701
115MP0006072_abnormal_retinal_apoptosis0.75798735
116MP0004130_abnormal_muscle_cell0.75197377
117MP0005397_hematopoietic_system_phenotyp0.75160724
118MP0001545_abnormal_hematopoietic_system0.75160724
119MP0002277_abnormal_respiratory_mucosa0.75065125
120MP0001986_abnormal_taste_sensitivity0.74674944
121MP0004142_abnormal_muscle_tone0.74278334
122MP0005636_abnormal_mineral_homeostasis0.73885229
123MP0009765_abnormal_xenobiotic_induced0.72336042
124MP0009384_cardiac_valve_regurgitation0.71740843
125MP0001486_abnormal_startle_reflex0.71587510
126MP0006276_abnormal_autonomic_nervous0.71015017
127MP0003011_delayed_dark_adaptation0.70645796
128MP0003186_abnormal_redox_activity0.69392824
129MP0000566_synostosis0.67742296
130MP0005464_abnormal_platelet_physiology0.65954381
131MP0000383_abnormal_hair_follicle0.65467464
132MP0005551_abnormal_eye_electrophysiolog0.65350468
133MP0002078_abnormal_glucose_homeostasis0.64157200
134MP0000613_abnormal_salivary_gland0.63620046
135MP0000579_abnormal_nail_morphology0.63174653
136MP0005666_abnormal_adipose_tissue0.62757908
137MP0003656_abnormal_erythrocyte_physiolo0.60996847
138MP0006036_abnormal_mitochondrial_physio0.60490691
139MP0004742_abnormal_vestibular_system0.59606367
140MP0000598_abnormal_liver_morphology0.58834887
141MP0002090_abnormal_vision0.58832639
142MP0002295_abnormal_pulmonary_circulatio0.57760025
143MP0005408_hypopigmentation0.55959624
144MP0000230_abnormal_systemic_arterial0.55608090
145MP0001853_heart_inflammation0.55333751
146MP0003950_abnormal_plasma_membrane0.55248921
147MP0009745_abnormal_behavioral_response0.55141270
148MP0002102_abnormal_ear_morphology0.55081745
149MP0003329_amyloid_beta_deposits0.53953331
150MP0005595_abnormal_vascular_smooth0.52841124
151MP0008874_decreased_physiological_sensi0.52498547
152MP0000647_abnormal_sebaceous_gland0.52453635
153MP0001346_abnormal_lacrimal_gland0.52057881
154MP0005448_abnormal_energy_balance0.51608852
155MP0002419_abnormal_innate_immunity0.50907054
156MP0003880_abnormal_central_pattern0.50688588
157MP0005376_homeostasis/metabolism_phenot0.49597001
158MP0006082_CNS_inflammation0.48147939
159MP0006035_abnormal_mitochondrial_morpho0.48045128
160MP0002148_abnormal_hypersensitivity_rea0.45603580
161MP0002272_abnormal_nervous_system0.45478419
162MP0004782_abnormal_surfactant_physiolog0.44852153
163MP0003638_abnormal_response/metabolism_0.44711625
164MP0002136_abnormal_kidney_physiology0.44200293

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.36477372
2Prolonged partial thromboplastin time (HP:0003645)5.78103196
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.67649730
4Deep venous thrombosis (HP:0002625)5.26163321
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.75955140
6Xanthomatosis (HP:0000991)4.54564835
7Joint hemorrhage (HP:0005261)4.36174418
8Acute necrotizing encephalopathy (HP:0006965)4.22579159
9Hyperlipoproteinemia (HP:0010980)4.19256851
10Complement deficiency (HP:0004431)4.06575841
11Conjugated hyperbilirubinemia (HP:0002908)4.05401322
12Hypobetalipoproteinemia (HP:0003563)4.03621895
13Abnormal mitochondria in muscle tissue (HP:0008316)4.02539325
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.99030036
15Abnormality of alanine metabolism (HP:0010916)3.99030036
16Hyperalaninemia (HP:0003348)3.99030036
17Hepatic necrosis (HP:0002605)3.83661329
18Epidermoid cyst (HP:0200040)3.72687324
19Progressive macrocephaly (HP:0004481)3.65023023
20Increased CSF lactate (HP:0002490)3.63264225
21Abnormality of methionine metabolism (HP:0010901)3.63100763
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61174690
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54759183
24Type I transferrin isoform profile (HP:0003642)3.54271031
25Hypoalphalipoproteinemia (HP:0003233)3.52029087
26Fat malabsorption (HP:0002630)3.50128182
27Hypolipoproteinemia (HP:0010981)3.47046509
28Hepatocellular necrosis (HP:0001404)3.39289374
29Hyperammonemia (HP:0001987)3.38816845
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.34542193
31Mitochondrial inheritance (HP:0001427)3.34431384
32Abnormal protein glycosylation (HP:0012346)3.33543177
33Abnormal glycosylation (HP:0012345)3.33543177
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.33543177
35Abnormal protein N-linked glycosylation (HP:0012347)3.33543177
36Abnormality of the common coagulation pathway (HP:0010990)3.30030607
37Abnormality of serine family amino acid metabolism (HP:0010894)3.29520602
38Abnormality of glycine metabolism (HP:0010895)3.29520602
39Hyperglycinemia (HP:0002154)3.28018295
40Increased serum lactate (HP:0002151)3.26521740
41Lactic acidosis (HP:0003128)3.26459658
42Ketosis (HP:0001946)3.25639960
43Reduced antithrombin III activity (HP:0001976)3.24669660
44Abnormality of sulfur amino acid metabolism (HP:0004339)3.20206209
45Hyperglycinuria (HP:0003108)3.11514516
46Abnormality of complement system (HP:0005339)3.04618669
47Parakeratosis (HP:0001036)3.01272185
48Increased serum pyruvate (HP:0003542)3.00963331
49Abnormality of glycolysis (HP:0004366)2.94942914
50Exercise intolerance (HP:0003546)2.83515240
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.81774398
52Decreased activity of mitochondrial respiratory chain (HP:0008972)2.81774398
533-Methylglutaconic aciduria (HP:0003535)2.81753155
54Nausea (HP:0002018)2.78697633
55Steatorrhea (HP:0002570)2.76191377
56Renal cortical cysts (HP:0000803)2.74310256
57Abnormality of pyrimidine metabolism (HP:0004353)2.73330630
58Patchy hypopigmentation of hair (HP:0011365)2.71279460
59Cerebral edema (HP:0002181)2.70773529
60Abnormality of fatty-acid metabolism (HP:0004359)2.67663547
61Hypoglycemic coma (HP:0001325)2.67078303
62Hypophosphatemic rickets (HP:0004912)2.63978386
63Abnormality of serum amino acid levels (HP:0003112)2.57507910
64Pancreatitis (HP:0001733)2.56825937
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56349509
66Vascular calcification (HP:0004934)2.54827140
67Hypochromic microcytic anemia (HP:0004840)2.53335771
68Metabolic acidosis (HP:0001942)2.52819319
69Myoglobinuria (HP:0002913)2.50985133
70Systemic lupus erythematosus (HP:0002725)2.50282525
71Hyperbilirubinemia (HP:0002904)2.48605288
72Ketoacidosis (HP:0001993)2.48305422
73Abnormality of the intrinsic pathway (HP:0010989)2.46022374
74Hypercholesterolemia (HP:0003124)2.44841791
75Enlarged kidneys (HP:0000105)2.44493297
76Chromsome breakage (HP:0040012)2.41639447
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41514433
78Dicarboxylic aciduria (HP:0003215)2.41514433
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39909876
80Fair hair (HP:0002286)2.38956888
81Respiratory failure (HP:0002878)2.38467182
82Abnormality of nucleobase metabolism (HP:0010932)2.38373670
83Recurrent gram-negative bacterial infections (HP:0005420)2.38283764
84Progressive muscle weakness (HP:0003323)2.38280139
85Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36163960
86Delayed CNS myelination (HP:0002188)2.35143231
87Myocardial infarction (HP:0001658)2.31737034
88Progressive external ophthalmoplegia (HP:0000590)2.28526608
89Lethargy (HP:0001254)2.27537595
90Hyperventilation (HP:0002883)2.27175336
91Glomerulonephritis (HP:0000099)2.24251488
92Spontaneous abortion (HP:0005268)2.23838950
93White forelock (HP:0002211)2.23485134
94Fatigue (HP:0012378)2.23074260
95Abnormality of purine metabolism (HP:0004352)2.20895190
96Cortical visual impairment (HP:0100704)2.18495780
97Vacuolated lymphocytes (HP:0001922)2.18442839
98Cardiovascular calcification (HP:0011915)2.17271483
99Microvesicular hepatic steatosis (HP:0001414)2.13471658
100Abnormality of proline metabolism (HP:0010907)2.12845979
101Hydroxyprolinuria (HP:0003080)2.12845979
102Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11552886
103Entropion (HP:0000621)2.10981447
104Menorrhagia (HP:0000132)2.10103904
105Upper motor neuron abnormality (HP:0002127)2.09383081
106Rickets (HP:0002748)2.09154599
107Amyloidosis (HP:0011034)2.08366979
108Acute hepatic failure (HP:0006554)2.08002399
109Abnormality of the heme biosynthetic pathway (HP:0010472)2.05939962
110Confusion (HP:0001289)2.04880920
111Rhabdomyolysis (HP:0003201)2.03973677
112Metaphyseal dysplasia (HP:0100255)2.02966566
113Optic disc pallor (HP:0000543)2.02330248
114Spastic paraparesis (HP:0002313)2.01961470
115Sparse eyelashes (HP:0000653)2.00133435
116Hemorrhage of the eye (HP:0011885)1.98590708
117Tubulointerstitial nephritis (HP:0001970)1.97524386
118Glycosuria (HP:0003076)1.97260251
119Abnormality of urine glucose concentration (HP:0011016)1.97260251
120Acanthocytosis (HP:0001927)1.96376352
121Increased intramyocellular lipid droplets (HP:0012240)1.96006071
122Abnormal gallbladder morphology (HP:0012437)1.95319644
123Cutaneous melanoma (HP:0012056)1.93873600
124Gingival bleeding (HP:0000225)1.93342427
125Abnormality of endocrine pancreas physiology (HP:0012093)1.93101320
126Abnormality of the pancreatic islet cells (HP:0006476)1.93101320
127Hyperinsulinemic hypoglycemia (HP:0000825)1.92636210
128Vomiting (HP:0002013)1.92180950
129Alkalosis (HP:0001948)1.92176653
130Sensorimotor neuropathy (HP:0007141)1.90923010
131Nephritis (HP:0000123)1.90888629
132Abnormality of the preputium (HP:0100587)1.89044177
133Skin nodule (HP:0200036)1.88861733
134Pulmonary embolism (HP:0002204)1.86753674
135Ragged-red muscle fibers (HP:0003200)1.86503702
136Generalized aminoaciduria (HP:0002909)1.85894193
137CNS demyelination (HP:0007305)1.85593595
138Elevated hepatic transaminases (HP:0002910)1.85169169
139Methylmalonic acidemia (HP:0002912)1.84763579
140Acute encephalopathy (HP:0006846)1.84497864
141Neurofibrillary tangles (HP:0002185)1.83368222
142Opisthotonus (HP:0002179)1.82590581
143Tetraparesis (HP:0002273)1.82293934
144Abnormality of vitamin metabolism (HP:0100508)1.80312955
145Respiratory difficulties (HP:0002880)1.79447491
146Insulin-resistant diabetes mellitus (HP:0000831)1.79207537
147Hypoglycemic seizures (HP:0002173)1.78173557
148Large for gestational age (HP:0001520)1.77566458
149Posterior subcapsular cataract (HP:0007787)1.77234587
150Recurrent corneal erosions (HP:0000495)1.76924259
151Abnormal gallbladder physiology (HP:0012438)1.75980179
152Cholecystitis (HP:0001082)1.75980179
153Cholelithiasis (HP:0001081)1.75437197
154Beaking of vertebral bodies (HP:0004568)1.73796047
155Leukodystrophy (HP:0002415)1.73191673
156Hypothermia (HP:0002045)1.71422804
157Palpitations (HP:0001962)1.71175352
158Abnormality of the renal cortex (HP:0011035)1.70892764
159Proximal tubulopathy (HP:0000114)1.70811222
160Symptomatic seizures (HP:0011145)1.70047356
161Hypoplasia of the uterus (HP:0000013)1.69286176
162Abnormal spermatogenesis (HP:0008669)1.69054315
163Horizontal nystagmus (HP:0000666)1.68968764
164Paralysis (HP:0003470)1.67652299
165Brittle hair (HP:0002299)1.67272864
166Decreased subcutaneous fat (HP:0001002)1.67144531
167Increased hepatocellular lipid droplets (HP:0006565)1.66029555
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.65877560
169Absent/shortened dynein arms (HP:0200106)1.65877560
170Renal Fanconi syndrome (HP:0001994)1.61581157
171Abnormality of the gallbladder (HP:0005264)1.59600224

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK24.82693942
2EIF2AK33.49233574
3EIF2AK13.40654007
4NME23.34646342
5IRAK23.32646095
6CASK3.17540779
7IRAK13.08820196
8MAP3K123.08764371
9NEK12.97274599
10IRAK32.72027033
11BCKDK2.52362158
12INSRR2.44700591
13VRK22.35390257
14BUB12.35103356
15SIK12.31323994
16STK392.14457208
17TAOK32.14191070
18CCNB12.10940922
19FGFR42.03946243
20PKN12.01270220
21CAMK1G1.99306349
22EPHB11.97236602
23STK161.95789338
24CAMK1D1.88284726
25WEE11.85499447
26MAP2K61.79635009
27TNIK1.77663927
28SCYL21.76287252
29CLK11.75820887
30PBK1.73382365
31OXSR11.68417367
32IRAK41.65708901
33NME11.61797443
34GRK71.60436787
35ERBB41.56467849
36NEK91.56030399
37PIK3CA1.50141880
38PIM21.46963467
39EPHA31.41186361
40FGFR21.39511214
41MST1R1.37770328
42TTK1.32888497
43ACVR1B1.32737712
44MAP3K141.32617564
45BLK1.30163365
46AKT31.27414000
47TXK1.27179332
48ZAK1.26865370
49ADRBK21.23027717
50GRK11.18332592
51PRKAA21.17995393
52NUAK11.17096690
53WNK41.15284695
54PLK41.14277233
55RPS6KB21.11984284
56CDK71.06404435
57VRK11.06152028
58PIK3CG1.04882329
59SRPK11.02903978
60PRKCQ1.02430423
61RIPK41.01347287
62TSSK60.99931708
63PLK10.99621382
64FRK0.98174163
65MKNK20.97151351
66TESK20.96359325
67NEK60.95311864
68BRSK20.94392557
69MST40.93018098
70ABL20.89837744
71JAK10.89236205
72ATR0.88725486
73PASK0.88284647
74TIE10.87672177
75FGR0.86194864
76FES0.85917744
77YES10.85617981
78TRIM280.84767869
79MAPK120.84400555
80MAPK150.83976199
81RPS6KA40.83533958
82ERBB30.82447608
83CSNK1G10.81893012
84CSNK1G30.80972352
85SIK30.79927078
86BMPR1B0.79301901
87CSNK1A1L0.76281570
88MAP2K40.76125589
89IKBKB0.75731608
90OBSCN0.75544294
91MET0.74665618
92BCR0.74062057
93MAP4K20.73725594
94PRKCE0.71913518
95SIK20.71550660
96MYLK0.71015870
97MAPK70.70341667
98CDK90.70228160
99BMPR20.69925883
100CDK30.69405967
101TESK10.68874221
102CSK0.68756827
103AURKA0.68465784
104CDK190.67819017
105PLK30.67245747
106WNK10.66636463
107PHKG10.66462683
108PHKG20.66462683
109MUSK0.65885178
110CAMK2G0.65603289
111STK100.65113884
112JAK30.64895431
113AURKB0.64696301
114MAP2K70.64673928
115DAPK10.64644761
116CSNK2A20.64487926
117EIF2AK20.63853353
118TEC0.62640420
119KIT0.62278168
120CSNK2A10.61609195
121PNCK0.61426051
122CSNK1G20.61401934
123SGK4940.61060512
124SGK2230.61060512
125TGFBR20.60538413
126CDK80.60220437
127CAMK2B0.59820764
128MARK30.56803672
129MAPK40.56765654
130MAPK110.56122549
131NTRK30.55961771
132CAMK2A0.55508202
133FLT30.54919012
134ATM0.54425850
135PRKCI0.52432968
136MAP3K130.51276865
137CHEK20.50690134
138PRKG10.50604546
139PRPF4B0.50192961
140NLK0.50137466
141TYK20.47406314
142SGK10.47230534
143PDPK10.46947783
144RPS6KB10.44875019
145CAMK2D0.44453686
146IKBKE0.44449285
147TLK10.44127828
148MAP3K110.44066746
149CHEK10.43963769
150LYN0.43337019
151CDC70.42839743
152ITK0.41749135
153MAPKAPK50.41087403
154PRKACA0.40863649
155IGF1R0.40259855
156CSF1R0.39573694
157LCK0.39404368
158PRKACG0.38986544
159HCK0.38833539
160ADRBK10.37954026
161MAP2K20.37723967
162STK30.37721111
163PIM10.37542414
164RPS6KA50.37001102
165BRSK10.34976877
166ARAF0.34242148
167MAP2K10.33488915
168CSNK1A10.32729539
169BMX0.29359786
170LIMK10.29148459
171FER0.28184086
172MAPKAPK20.27659289
173GRK50.23596383

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96493696
2Proteasome_Homo sapiens_hsa030503.61380767
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71363528
4Tryptophan metabolism_Homo sapiens_hsa003802.66702237
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.66183218
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60603602
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.55330153
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52626869
9Nitrogen metabolism_Homo sapiens_hsa009102.49944248
10Complement and coagulation cascades_Homo sapiens_hsa046102.47595623
11Fatty acid degradation_Homo sapiens_hsa000712.42413672
12Propanoate metabolism_Homo sapiens_hsa006402.38675392
13Ribosome_Homo sapiens_hsa030102.38184103
14Histidine metabolism_Homo sapiens_hsa003402.36738247
15Butanoate metabolism_Homo sapiens_hsa006502.36252194
16Fatty acid elongation_Homo sapiens_hsa000622.34229512
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31000880
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25089500
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.24650024
20Arginine biosynthesis_Homo sapiens_hsa002202.22937910
21Mismatch repair_Homo sapiens_hsa034302.22168545
22RNA polymerase_Homo sapiens_hsa030202.22037910
23Peroxisome_Homo sapiens_hsa041462.17698893
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.17521476
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08308822
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07428151
27beta-Alanine metabolism_Homo sapiens_hsa004102.06569431
28Homologous recombination_Homo sapiens_hsa034402.05688026
29Steroid hormone biosynthesis_Homo sapiens_hsa001402.04953020
30Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03438935
31Sulfur metabolism_Homo sapiens_hsa009202.02330148
32DNA replication_Homo sapiens_hsa030302.00479498
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98299963
34* Fatty acid metabolism_Homo sapiens_hsa012121.86791563
35PPAR signaling pathway_Homo sapiens_hsa033201.84732997
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84359739
37Chemical carcinogenesis_Homo sapiens_hsa052041.84177809
38Staphylococcus aureus infection_Homo sapiens_hsa051501.84155820
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79426102
40Steroid biosynthesis_Homo sapiens_hsa001001.78051489
41Base excision repair_Homo sapiens_hsa034101.77179945
42Retinol metabolism_Homo sapiens_hsa008301.73998897
43Pyrimidine metabolism_Homo sapiens_hsa002401.73918356
44Phenylalanine metabolism_Homo sapiens_hsa003601.71048698
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66537922
46Nucleotide excision repair_Homo sapiens_hsa034201.56686567
47Tyrosine metabolism_Homo sapiens_hsa003501.56669471
48RNA transport_Homo sapiens_hsa030131.53756302
49Non-homologous end-joining_Homo sapiens_hsa034501.49807002
50Fanconi anemia pathway_Homo sapiens_hsa034601.48100190
51ABC transporters_Homo sapiens_hsa020101.46993113
52Basal transcription factors_Homo sapiens_hsa030221.36037532
53Huntingtons disease_Homo sapiens_hsa050161.35825273
54Starch and sucrose metabolism_Homo sapiens_hsa005001.29895850
55RNA degradation_Homo sapiens_hsa030181.28452952
56Caffeine metabolism_Homo sapiens_hsa002321.26913478
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24408814
58Bile secretion_Homo sapiens_hsa049761.22102492
59Pyruvate metabolism_Homo sapiens_hsa006201.21489710
60N-Glycan biosynthesis_Homo sapiens_hsa005101.21161152
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19026565
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.15677338
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15517083
64Arginine and proline metabolism_Homo sapiens_hsa003301.11949915
65Purine metabolism_Homo sapiens_hsa002301.08927872
66SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04735354
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04452404
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.00644637
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99422019
70Spliceosome_Homo sapiens_hsa030400.99355880
71Lysine degradation_Homo sapiens_hsa003100.96405599
72Vitamin digestion and absorption_Homo sapiens_hsa049770.96089146
73Folate biosynthesis_Homo sapiens_hsa007900.93605915
74Fat digestion and absorption_Homo sapiens_hsa049750.84447095
75Regulation of autophagy_Homo sapiens_hsa041400.84345720
76Fructose and mannose metabolism_Homo sapiens_hsa000510.82025901
77Other glycan degradation_Homo sapiens_hsa005110.81146581
78Vitamin B6 metabolism_Homo sapiens_hsa007500.80320818
79Selenocompound metabolism_Homo sapiens_hsa004500.79158184
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78833117
81Linoleic acid metabolism_Homo sapiens_hsa005910.73532647
82Cell cycle_Homo sapiens_hsa041100.71724874
83Collecting duct acid secretion_Homo sapiens_hsa049660.70020411
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68924209
85Glycerolipid metabolism_Homo sapiens_hsa005610.67152501
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.66047703
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65448227
88Glutathione metabolism_Homo sapiens_hsa004800.64186617
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.62876804
90Ether lipid metabolism_Homo sapiens_hsa005650.62583878
91Carbon metabolism_Homo sapiens_hsa012000.61191650
92mRNA surveillance pathway_Homo sapiens_hsa030150.59272258
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58613385
94* Metabolic pathways_Homo sapiens_hsa011000.55052135
95* Fatty acid biosynthesis_Homo sapiens_hsa000610.54172785
96Galactose metabolism_Homo sapiens_hsa000520.51820302
97Sulfur relay system_Homo sapiens_hsa041220.51539206
98Oxidative phosphorylation_Homo sapiens_hsa001900.48929497
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45951418
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45542777
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42798616
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41651011
103Oocyte meiosis_Homo sapiens_hsa041140.37335934
104Sphingolipid metabolism_Homo sapiens_hsa006000.37251597
105Arachidonic acid metabolism_Homo sapiens_hsa005900.35668076
106Biosynthesis of amino acids_Homo sapiens_hsa012300.34051353
107p53 signaling pathway_Homo sapiens_hsa041150.27938361
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27253899
109Vibrio cholerae infection_Homo sapiens_hsa051100.27176148
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26837286
111African trypanosomiasis_Homo sapiens_hsa051430.25421220
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.22806583
113Alzheimers disease_Homo sapiens_hsa050100.22535273
114Prion diseases_Homo sapiens_hsa050200.22509280
115Ovarian steroidogenesis_Homo sapiens_hsa049130.20608929
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14087400
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12656566
118Serotonergic synapse_Homo sapiens_hsa047260.12646892
119Nicotine addiction_Homo sapiens_hsa050330.12137863
120Pentose phosphate pathway_Homo sapiens_hsa000300.10574531
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.10541688
122Parkinsons disease_Homo sapiens_hsa050120.08896732
123Rheumatoid arthritis_Homo sapiens_hsa053230.08725410
124One carbon pool by folate_Homo sapiens_hsa006700.08621445
125Autoimmune thyroid disease_Homo sapiens_hsa053200.07951024
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07828358
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.07528795
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.06335743
129Graft-versus-host disease_Homo sapiens_hsa053320.06113681
130Malaria_Homo sapiens_hsa051440.05458427
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.03138933
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00421627
133Insulin resistance_Homo sapiens_hsa049310.00249238
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0321161
135Allograft rejection_Homo sapiens_hsa05330-0.0252556
136Protein export_Homo sapiens_hsa03060-0.0182839
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.0090255

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