OXLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)9.16346413
2proline metabolic process (GO:0006560)8.86456031
3DNA deamination (GO:0045006)8.48640983
4replication fork processing (GO:0031297)7.30846945
5embryonic process involved in female pregnancy (GO:0060136)7.14030913
6positive regulation of protein homooligomerization (GO:0032464)6.72352189
7oxidative demethylation (GO:0070989)6.39476928
8regulation of protein homooligomerization (GO:0032462)6.02062058
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.98605602
10regulation of integrin activation (GO:0033623)5.79342759
11mitochondrial DNA metabolic process (GO:0032042)5.78614561
12establishment of apical/basal cell polarity (GO:0035089)5.50428167
13deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.27964384
14poly(A)+ mRNA export from nucleus (GO:0016973)5.12430724
15somatic diversification of immune receptors via somatic mutation (GO:0002566)5.04120456
16somatic hypermutation of immunoglobulin genes (GO:0016446)5.04120456
17viral mRNA export from host cell nucleus (GO:0046784)4.95649148
18glutamine family amino acid biosynthetic process (GO:0009084)4.94448287
19DNA strand renaturation (GO:0000733)4.85018407
20negative regulation of fatty acid biosynthetic process (GO:0045717)4.77992787
21mitotic G1 DNA damage checkpoint (GO:0031571)4.74925210
22establishment of monopolar cell polarity (GO:0061162)4.73261830
23establishment or maintenance of monopolar cell polarity (GO:0061339)4.73261830
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.69006121
25cellular response to zinc ion (GO:0071294)4.57975968
26mitochondrial RNA metabolic process (GO:0000959)4.56200636
27negative regulation of JAK-STAT cascade (GO:0046426)4.51620033
28negative regulation of cell cycle arrest (GO:0071157)4.43963153
29formation of translation preinitiation complex (GO:0001731)4.41909591
30cellular response to ATP (GO:0071318)4.41565021
31embryonic placenta development (GO:0001892)4.34271212
32mRNA cleavage (GO:0006379)4.31729122
33regulation of translational fidelity (GO:0006450)4.29167052
34GDP-mannose metabolic process (GO:0019673)4.23896766
35negative regulation of protein oligomerization (GO:0032460)4.12819429
36G1 DNA damage checkpoint (GO:0044783)4.12203673
37mitotic G1/S transition checkpoint (GO:0044819)4.11781934
38telomere maintenance via semi-conservative replication (GO:0032201)4.10241622
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.10165823
40sulfur amino acid catabolic process (GO:0000098)4.00226597
41base-excision repair (GO:0006284)3.97029988
42DNA integration (GO:0015074)3.96705785
43positive regulation of developmental pigmentation (GO:0048087)3.94794806
44deoxyribonucleotide catabolic process (GO:0009264)3.94270946
45purine deoxyribonucleotide catabolic process (GO:0009155)3.89720157
46viral transcription (GO:0019083)3.82274877
47deoxyribose phosphate catabolic process (GO:0046386)3.80814275
48negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.77612073
49ribosomal small subunit assembly (GO:0000028)3.75821360
50positive regulation of protein oligomerization (GO:0032461)3.71800826
51base-excision repair, AP site formation (GO:0006285)3.71544611
52ribosomal small subunit biogenesis (GO:0042274)3.71279590
53negative regulation of B cell apoptotic process (GO:0002903)3.71090716
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.70733585
55negative regulation of Ras GTPase activity (GO:0034261)3.64093276
56regulation of protein oligomerization (GO:0032459)3.62996675
57nucleotide-excision repair, DNA gap filling (GO:0006297)3.62250866
58non-recombinational repair (GO:0000726)3.62140505
59double-strand break repair via nonhomologous end joining (GO:0006303)3.62140505
60spliceosomal tri-snRNP complex assembly (GO:0000244)3.61803313
61positive regulation by host of viral transcription (GO:0043923)3.50984017
62translational termination (GO:0006415)3.50212346
63mitochondrial DNA replication (GO:0006264)3.48582673
64metallo-sulfur cluster assembly (GO:0031163)3.47296762
65iron-sulfur cluster assembly (GO:0016226)3.47296762
66pyrimidine nucleotide catabolic process (GO:0006244)3.43661612
67alkaloid metabolic process (GO:0009820)3.43195392
68oxidative phosphorylation (GO:0006119)3.41621289
69convergent extension (GO:0060026)3.34984548
70rRNA modification (GO:0000154)3.33597730
71translational elongation (GO:0006414)3.33049436
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29036493
73termination of RNA polymerase II transcription (GO:0006369)3.28152148
74dosage compensation (GO:0007549)3.26991148
75embryonic camera-type eye development (GO:0031076)3.26368789
76positive regulation of DNA repair (GO:0045739)3.25931809
77very-low-density lipoprotein particle assembly (GO:0034379)3.25276002
78negative regulation of mRNA processing (GO:0050686)3.24920214
79telomere maintenance via recombination (GO:0000722)3.22488517
80negative regulation of heart rate (GO:0010459)3.21428817
81regulation of double-strand break repair via homologous recombination (GO:0010569)3.19666442
82positive regulation of B cell differentiation (GO:0045579)3.17801701
83pentose metabolic process (GO:0019321)3.17500615
84labyrinthine layer development (GO:0060711)3.15342990
85protein maturation by protein folding (GO:0022417)3.14688320
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14644797
87glial cell migration (GO:0008347)3.14463778
88DNA demethylation (GO:0080111)3.14397200
89maturation of 5.8S rRNA (GO:0000460)3.14133982
90apoptotic process involved in morphogenesis (GO:0060561)3.13504310
91face development (GO:0060324)3.13462322
92DNA strand elongation involved in DNA replication (GO:0006271)3.10703946
93DNA ligation (GO:0006266)3.09652650
94peptidyl-arginine omega-N-methylation (GO:0035247)3.09479441
95DNA topological change (GO:0006265)3.08545738
96regulation of mitochondrial depolarization (GO:0051900)3.06335200
972-deoxyribonucleotide metabolic process (GO:0009394)3.04424406
98protein targeting to ER (GO:0045047)3.04256083
99viral life cycle (GO:0019058)3.03632566
100cotranslational protein targeting to membrane (GO:0006613)3.03091597
101histone H4-K12 acetylation (GO:0043983)3.03081694
102regulation of mitochondrial translation (GO:0070129)3.02981274
103nuclear envelope reassembly (GO:0031468)3.02597332
104mitotic nuclear envelope reassembly (GO:0007084)3.02597332
105DNA double-strand break processing (GO:0000729)3.02514734
106anatomical structure regression (GO:0060033)3.01899908
107nucleotide salvage (GO:0043173)2.97910915
108negative regulation of tumor necrosis factor production (GO:0032720)2.96976992
109protein localization to endoplasmic reticulum (GO:0070972)2.96914287
110negative regulation of appetite (GO:0032099)2.96897935
111negative regulation of response to food (GO:0032096)2.96897935
112glycerol ether metabolic process (GO:0006662)2.96826589
113meiotic chromosome segregation (GO:0045132)2.95637749
114negative regulation of fatty acid metabolic process (GO:0045922)2.95316772
115mitochondrial fusion (GO:0008053)2.95043931
116negative regulation of RNA splicing (GO:0033119)2.94879649
117heme biosynthetic process (GO:0006783)2.91079012
118DNA strand elongation (GO:0022616)2.91057774
119cullin deneddylation (GO:0010388)2.90612363
120trophectodermal cell differentiation (GO:0001829)2.89589238
121regulation of cell size (GO:0008361)2.89249354
122regulation of B cell apoptotic process (GO:0002902)2.88875654
123resolution of meiotic recombination intermediates (GO:0000712)2.88330864
124deoxyribose phosphate metabolic process (GO:0019692)2.87771449
125regulation of sister chromatid cohesion (GO:0007063)2.86842681
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86694597
127protein targeting to mitochondrion (GO:0006626)2.85759714
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85739088
129negative regulation of phagocytosis (GO:0050765)2.85488849
130negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.85303021
131regulation of RNA export from nucleus (GO:0046831)2.85175901
132purine deoxyribonucleotide metabolic process (GO:0009151)2.84427085
133guanosine-containing compound biosynthetic process (GO:1901070)2.81629926
134maturation of SSU-rRNA (GO:0030490)2.80589365
135T cell apoptotic process (GO:0070231)2.79990183
136negative regulation of myeloid cell apoptotic process (GO:0033033)2.79064382
137autophagic vacuole fusion (GO:0000046)2.77995668
138immunoglobulin mediated immune response (GO:0016064)2.76318807
139ribosomal large subunit biogenesis (GO:0042273)2.75741680
140deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.74059949
141translational initiation (GO:0006413)2.73670649
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69862601
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.69333731
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.69333731
145ribonucleoprotein complex biogenesis (GO:0022613)2.67238955
146mitochondrial calcium ion transport (GO:0006851)2.66941242
147cellular protein complex disassembly (GO:0043624)2.64973195
148positive regulation of gamma-delta T cell activation (GO:0046645)2.61764989
149purine nucleotide salvage (GO:0032261)2.61186211
150translation (GO:0006412)2.61171992
151positive regulation of granulocyte differentiation (GO:0030854)2.58999182
152establishment of protein localization to mitochondrion (GO:0072655)2.58923208
153energy coupled proton transport, down electrochemical gradient (GO:0015985)2.57926875
154ATP synthesis coupled proton transport (GO:0015986)2.57926875
155UV protection (GO:0009650)2.56975603
156response to interferon-beta (GO:0035456)2.54368112
157GTP biosynthetic process (GO:0006183)2.54274502
158rRNA methylation (GO:0031167)2.54046533
159mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53909148
160chaperone-mediated protein transport (GO:0072321)2.53471078
161pseudouridine synthesis (GO:0001522)2.51743400
162UTP biosynthetic process (GO:0006228)2.51672925
163B cell mediated immunity (GO:0019724)2.50771914
164pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.50099387
165positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.49544022
166deoxyribonucleotide metabolic process (GO:0009262)2.48758866
167cellular component biogenesis (GO:0044085)2.48083920
168rRNA transcription (GO:0009303)2.47217866
169tRNA modification (GO:0006400)2.46990051
170protein complex disassembly (GO:0043241)2.46601540
171protoporphyrinogen IX biosynthetic process (GO:0006782)2.45493300
172termination of RNA polymerase III transcription (GO:0006386)2.45146204
173transcription elongation from RNA polymerase III promoter (GO:0006385)2.45146204
174pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.44726229
175negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.44667401
176pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.44519473
177pentose-phosphate shunt (GO:0006098)2.44202382
178CTP metabolic process (GO:0046036)2.42100322
179CTP biosynthetic process (GO:0006241)2.42100322
180pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.40897748
181protein localization to mitochondrion (GO:0070585)2.40130915
182aerobic respiration (GO:0009060)2.38959285
183tRNA methylation (GO:0030488)2.38725506
184regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38397953
185histone arginine methylation (GO:0034969)2.37367797
186protein complex biogenesis (GO:0070271)2.37173722
1872-deoxyribonucleotide biosynthetic process (GO:0009265)2.36704621
188deoxyribose phosphate biosynthetic process (GO:0046385)2.36704621
189proline biosynthetic process (GO:0006561)11.3706956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07302837
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.06465215
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96551322
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89138166
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79747489
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.64520738
7VDR_21846776_ChIP-Seq_THP-1_Human2.59187812
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38375714
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29491344
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.26405684
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23998054
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23998054
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23998054
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16737620
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10347324
16LXR_22292898_ChIP-Seq_THP-1_Human2.04294196
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04257954
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02205937
19STAT3_1855785_ChIP-Seq_MESCs_Mouse1.98814746
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98302882
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.97325358
22KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.97122437
23SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96495363
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91081657
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.88941925
26PU.1_20513432_ChIP-Seq_Bcells_Mouse1.88683341
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88499729
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87596890
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86919854
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.84314440
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82477512
32NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81845412
33POU5F1_16518401_ChIP-PET_MESCs_Mouse1.80820031
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.78209712
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73660008
36RXR_22158963_ChIP-Seq_LIVER_Mouse1.71138015
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68778373
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68704108
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68620917
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68508224
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.68359373
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.67359446
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65817067
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.64534590
45FOXP3_21729870_ChIP-Seq_TREG_Human1.62698085
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61358994
47CIITA_25753668_ChIP-Seq_RAJI_Human1.60149613
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.58961934
49TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58563014
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58191596
51ZNF263_19887448_ChIP-Seq_K562_Human1.57954394
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.57226583
53MYC_22102868_ChIP-Seq_BL_Human1.56899900
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.55949902
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.55732754
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52264819
57VDR_23849224_ChIP-Seq_CD4+_Human1.52164549
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.50334950
59MAF_26560356_Chip-Seq_TH2_Human1.49219422
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48364968
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48223896
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.46271864
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45043666
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44544619
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44099946
66MAF_26560356_Chip-Seq_TH1_Human1.43707830
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43367781
68UTX_26944678_Chip-Seq_JUKART_Human1.43195666
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43148400
70P68_20966046_ChIP-Seq_HELA_Human1.41773235
71GABP_19822575_ChIP-Seq_HepG2_Human1.41582186
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38996989
73DCP1A_22483619_ChIP-Seq_HELA_Human1.37545955
74RACK7_27058665_Chip-Seq_MCF-7_Human1.37507035
75* SPI1_23547873_ChIP-Seq_NB4_Human1.36969672
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35429689
77E2F7_22180533_ChIP-Seq_HELA_Human1.35020388
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34920459
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.34809513
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34781204
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34769587
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33409572
83TTF2_22483619_ChIP-Seq_HELA_Human1.33037461
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32760427
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31713389
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30399566
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29670687
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.29588595
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29113902
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28304126
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.27442052
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27211887
93VDR_24763502_ChIP-Seq_THP-1_Human1.26387889
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25100976
95ETS1_21867929_ChIP-Seq_TH2_Mouse1.24882595
96MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24388136
97CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23242272
98CTCF_26484167_Chip-Seq_Bcells_Mouse1.23106415
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22623702
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22400376
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22017819
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20763584
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.20672241
104SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20580048
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20273810
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20190740
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20050746
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19038684
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18838384
110SCL_19346495_ChIP-Seq_HPC-7_Human1.18604126
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18260707
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17739247
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17311460
114NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16682828
115FOXP1_21924763_ChIP-Seq_HESCs_Human1.16593459
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16497312
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16321054
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16260672
119RUNX1_22412390_ChIP-Seq_EML_Mouse1.15452573
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15319301
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15213262
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.15077977
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14566469
124RARA_24833708_ChIP-Seq_LIVER_Mouse1.14008877
125XRN2_22483619_ChIP-Seq_HELA_Human1.13539367
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13236756
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13092458
128ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12723851
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12226048
130OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12123835
131BCOR_27268052_Chip-Seq_Bcells_Human1.10861401
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10614014
133STAT1_20625510_ChIP-Seq_HELA_Human1.10432987
134TFEB_21752829_ChIP-Seq_HELA_Human1.10292005
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09871604
136NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09532827
137CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09334399
138YY1_22570637_ChIP-Seq_MALME-3M_Human1.08634388
139PHF8_20622854_ChIP-Seq_HELA_Human1.08592357
140KDM5A_27292631_Chip-Seq_BREAST_Human1.08153314
141NCOR1_26117541_ChIP-Seq_K562_Human1.07815726
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07809874
143* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07480923
144SRF_21415370_ChIP-Seq_HL-1_Mouse1.07440317
145ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06843757
146SPI1_26923725_Chip-Seq_HPCs_Mouse1.06524271
147KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06122883
148ELK3_25401928_ChIP-Seq_HUVEC_Human1.05880757
149GABP_17652178_ChIP-ChIP_JURKAT_Human1.05754115
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05337962
151BCL6_27268052_Chip-Seq_Bcells_Human1.05292647
152CTCF_21964334_Chip-Seq_Bcells_Human1.05114831
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03029511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.94107507
2MP0005171_absent_coat_pigmentation4.38692335
3MP0009278_abnormal_bone_marrow4.17995771
4MP0004233_abnormal_muscle_weight3.53880191
5MP0010030_abnormal_orbit_morphology3.31528992
6MP0002009_preneoplasia3.29355351
7MP0001873_stomach_inflammation3.23902850
8MP0005451_abnormal_body_composition2.94798757
9MP0001835_abnormal_antigen_presentation2.81648742
10MP0000465_gastrointestinal_hemorrhage2.72016732
11MP0008260_abnormal_autophagy2.71759969
12MP0003436_decreased_susceptibility_to2.62212985
13MP0008995_early_reproductive_senescence2.60145132
14MP0005397_hematopoietic_system_phenotyp2.57526471
15MP0001545_abnormal_hematopoietic_system2.57526471
16MP0005085_abnormal_gallbladder_physiolo2.52506835
17MP0003763_abnormal_thymus_physiology2.47089420
18MP0005365_abnormal_bile_salt2.44199123
19MP0005671_abnormal_response_to2.34560850
20MP0005464_abnormal_platelet_physiology2.29975552
21MP0005174_abnormal_tail_pigmentation2.18566110
22MP0005025_abnormal_response_to2.15469389
23MP0005000_abnormal_immune_tolerance2.13013164
24MP0000372_irregular_coat_pigmentation2.11703076
25MP0001800_abnormal_humoral_immune2.06410122
26MP0003786_premature_aging1.97394709
27MP0002420_abnormal_adaptive_immunity1.96737268
28MP0001819_abnormal_immune_cell1.95582468
29MP0010094_abnormal_chromosome_stability1.95316974
30MP0005075_abnormal_melanosome_morpholog1.94690609
31MP0006072_abnormal_retinal_apoptosis1.93493053
32MP0002148_abnormal_hypersensitivity_rea1.92925373
33MP0002398_abnormal_bone_marrow1.92614872
34MP0002419_abnormal_innate_immunity1.89652091
35MP0002723_abnormal_immune_serum1.89540470
36MP0003890_abnormal_embryonic-extraembry1.88555567
37MP0002452_abnormal_antigen_presenting1.83532026
38MP0004133_heterotaxia1.83330603
39MP0002249_abnormal_larynx_morphology1.79909072
40MP0002269_muscular_atrophy1.77114727
41MP0009785_altered_susceptibility_to1.76389814
42MP0003283_abnormal_digestive_organ1.76136079
43MP0003172_abnormal_lysosome_physiology1.75725875
44MP0002722_abnormal_immune_system1.75112368
45MP0003656_abnormal_erythrocyte_physiolo1.71633466
46MP0004957_abnormal_blastocyst_morpholog1.71524835
47MP0000689_abnormal_spleen_morphology1.68504185
48MP0005058_abnormal_lysosome_morphology1.68221982
49MP0000716_abnormal_immune_system1.68208554
50MP0002396_abnormal_hematopoietic_system1.67257960
51MP0002234_abnormal_pharynx_morphology1.66319882
52MP0002429_abnormal_blood_cell1.63078159
53MP0003453_abnormal_keratinocyte_physiol1.60973842
54MP0003806_abnormal_nucleotide_metabolis1.59233710
55MP0003119_abnormal_digestive_system1.58961996
56MP0000703_abnormal_thymus_morphology1.56358118
57MP0003186_abnormal_redox_activity1.55724750
58MP0002282_abnormal_trachea_morphology1.54507104
59MP0005330_cardiomyopathy1.52136924
60MP0003567_abnormal_fetal_cardiomyocyte1.52126231
61MP0001790_abnormal_immune_system1.50637481
62MP0005387_immune_system_phenotype1.50637481
63MP0003191_abnormal_cellular_cholesterol1.49505558
64MP0008058_abnormal_DNA_repair1.48753219
65MP0000490_abnormal_crypts_of1.48592684
66MP0002653_abnormal_ependyma_morphology1.44395857
67MP0001293_anophthalmia1.42902077
68MP0002086_abnormal_extraembryonic_tissu1.41449884
69MP0006035_abnormal_mitochondrial_morpho1.39582206
70MP0010352_gastrointestinal_tract_polyps1.38668854
71MP0000371_diluted_coat_color1.38426340
72MP0003137_abnormal_impulse_conducting1.36604350
73MP0005266_abnormal_metabolism1.33962788
74MP0001697_abnormal_embryo_size1.32372392
75MP0003828_pulmonary_edema1.31853298
76MP0000015_abnormal_ear_pigmentation1.31711637
77MP0000579_abnormal_nail_morphology1.31046527
78MP0001845_abnormal_inflammatory_respons1.30860621
79MP0004185_abnormal_adipocyte_glucose1.29674904
80MP0001853_heart_inflammation1.24936228
81MP0008932_abnormal_embryonic_tissue1.23871980
82MP0000639_abnormal_adrenal_gland1.23812163
83MP0006036_abnormal_mitochondrial_physio1.21202898
84MP0008469_abnormal_protein_level1.20532055
85MP0000678_abnormal_parathyroid_gland1.20191653
86MP0009840_abnormal_foam_cell1.19882321
87MP0002084_abnormal_developmental_patter1.19040463
88MP0004197_abnormal_fetal_growth/weight/1.18636751
89MP0000470_abnormal_stomach_morphology1.18014636
90MP0000681_abnormal_thyroid_gland1.17065402
91MP0010155_abnormal_intestine_physiology1.15523623
92MP0004947_skin_inflammation1.15392980
93MP0003866_abnormal_defecation1.13697963
94MP0005666_abnormal_adipose_tissue1.12600318
95MP0000685_abnormal_immune_system1.08502152
96MP0003111_abnormal_nucleus_morphology1.07361165
97MP0009115_abnormal_fat_cell1.05087659
98MP0002085_abnormal_embryonic_tissue1.04931056
99MP0005076_abnormal_cell_differentiation1.04437806
100MP0002166_altered_tumor_susceptibility1.03336910
101MP0004808_abnormal_hematopoietic_stem1.01748020
102MP0010630_abnormal_cardiac_muscle1.01100313
103MP0000858_altered_metastatic_potential1.00354527
104MP0003693_abnormal_embryo_hatching0.98915574
105MP0004147_increased_porphyrin_level0.98848589
106MP0002796_impaired_skin_barrier0.97893283
107MP0002019_abnormal_tumor_incidence0.97545247
108MP0001672_abnormal_embryogenesis/_devel0.97526568
109MP0005380_embryogenesis_phenotype0.97526568
110MP0002139_abnormal_hepatobiliary_system0.97139326
111MP0003075_altered_response_to0.96467418
112MP0002332_abnormal_exercise_endurance0.94998379
113MP0001661_extended_life_span0.94891513
114MP0004019_abnormal_vitamin_homeostasis0.94607269
115MP0004381_abnormal_hair_follicle0.93855736
116MP0000751_myopathy0.92282253
117MP0008877_abnormal_DNA_methylation0.92188881
118MP0000358_abnormal_cell_content/0.91853484
119MP0008873_increased_physiological_sensi0.91413960
120MP0003724_increased_susceptibility_to0.90727014
121MP0003303_peritoneal_inflammation0.90668282
122MP0001340_abnormal_eyelid_morphology0.90094471
123MP0000462_abnormal_digestive_system0.89635825
124MP0005360_urolithiasis0.87223355
125MP0001324_abnormal_eye_pigmentation0.86996306
126MP0003077_abnormal_cell_cycle0.86867230
127MP0002111_abnormal_tail_morphology0.85683116
128MP0002970_abnormal_white_adipose0.85368187
129MP0002075_abnormal_coat/hair_pigmentati0.84005185
130MP0002080_prenatal_lethality0.82186527
131MP0002932_abnormal_joint_morphology0.81446337
132MP0008007_abnormal_cellular_replicative0.81047997
133MP0005332_abnormal_amino_acid0.80952361
134MP0001764_abnormal_homeostasis0.80513743
135MP0003718_maternal_effect0.80477292
136MP0001533_abnormal_skeleton_physiology0.79596787
137MP0004142_abnormal_muscle_tone0.78076333
138MP0009764_decreased_sensitivity_to0.77994605
139MP0002822_catalepsy0.76280786
140MP0009763_increased_sensitivity_to0.75709382
141MP0002971_abnormal_brown_adipose0.75238090
142MP0005375_adipose_tissue_phenotype0.75025278
143MP0003984_embryonic_growth_retardation0.74981278
144MP0004130_abnormal_muscle_cell0.74551002
145MP0005319_abnormal_enzyme/_coenzyme0.74440719
146MP0002405_respiratory_system_inflammati0.73796722
147MP0000350_abnormal_cell_proliferation0.73316327
148MP0005376_homeostasis/metabolism_phenot0.73248707
149MP0009333_abnormal_splenocyte_physiolog0.72996679
150MP0001663_abnormal_digestive_system0.72361407
151MP0001730_embryonic_growth_arrest0.72221250
152MP0002060_abnormal_skin_morphology0.71967031
153MP0005584_abnormal_enzyme/coenzyme_acti0.71441483
154MP0006082_CNS_inflammation0.70704004
155MP0002088_abnormal_embryonic_growth/wei0.70223764
156MP0002132_abnormal_respiratory_system0.70090658
157MP0010307_abnormal_tumor_latency0.69704391
158MP0005166_decreased_susceptibility_to0.69204211
159MP0002163_abnormal_gland_morphology0.68500136
160MP0001186_pigmentation_phenotype0.68325793
161MP0003221_abnormal_cardiomyocyte_apopto0.67529383
162MP0000762_abnormal_tongue_morphology0.66834772
163MP0000313_abnormal_cell_death0.66630689
164MP0000609_abnormal_liver_physiology0.66535051
165MP0000598_abnormal_liver_morphology0.66345416
166MP0005501_abnormal_skin_physiology0.65546363

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.48848363
2Poikiloderma (HP:0001029)5.16513153
3Concave nail (HP:0001598)5.11504687
4Annular pancreas (HP:0001734)4.98846575
5Rib fusion (HP:0000902)4.97916843
6Increased IgM level (HP:0003496)4.88794676
7Rectovaginal fistula (HP:0000143)4.61119205
8Rectal fistula (HP:0100590)4.61119205
9Alopecia of scalp (HP:0002293)4.42526297
10Hypochromic microcytic anemia (HP:0004840)4.41976311
11Facial hemangioma (HP:0000329)4.41699727
12Turricephaly (HP:0000262)4.39816463
13Vaginal fistula (HP:0004320)4.30986197
14Abnormal hemoglobin (HP:0011902)4.08455924
15Intestinal fistula (HP:0100819)4.06734259
16Tongue fasciculations (HP:0001308)4.06507817
17Chronic obstructive pulmonary disease (HP:0006510)4.03926660
18Obstructive lung disease (HP:0006536)4.03926660
19Hepatocellular necrosis (HP:0001404)3.82963360
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.82469017
21Muscle fibrillation (HP:0010546)3.80972502
22Ulnar bowing (HP:0003031)3.80309542
23Agammaglobulinemia (HP:0004432)3.76021981
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.68170829
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.68170829
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.66769082
27Orthostatic hypotension (HP:0001278)3.58565449
28Large for gestational age (HP:0001520)3.55344355
29Coronal craniosynostosis (HP:0004440)3.53501527
30Mucopolysacchariduria (HP:0008155)3.52867999
31Urinary glycosaminoglycan excretion (HP:0003541)3.52867999
32Abnormal mitochondria in muscle tissue (HP:0008316)3.49955621
33Hypertensive crisis (HP:0100735)3.47154578
34Pancreatic islet-cell hyperplasia (HP:0004510)3.46257903
35Male infertility (HP:0003251)3.36121147
36Mitochondrial inheritance (HP:0001427)3.35788396
37Hepatic necrosis (HP:0002605)3.35074034
38Intestinal atresia (HP:0011100)3.32426904
39Increased muscle lipid content (HP:0009058)3.30586258
40Short humerus (HP:0005792)3.29476213
41Abnormality of T cell physiology (HP:0011840)3.26032910
42Panhypogammaglobulinemia (HP:0003139)3.25799555
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.24780835
44Vertebral hypoplasia (HP:0008417)3.24780835
45Dysautonomia (HP:0002459)3.24647270
46Albinism (HP:0001022)3.24510119
47Microvesicular hepatic steatosis (HP:0001414)3.23628145
48Abnormality of male internal genitalia (HP:0000022)3.23549689
49Increased intramyocellular lipid droplets (HP:0012240)3.21830979
50Aplasia/hypoplasia of the humerus (HP:0006507)3.21008616
51Diaphragmatic weakness (HP:0009113)3.17633783
52Acute necrotizing encephalopathy (HP:0006965)3.12874368
53Abnormality of polysaccharide metabolism (HP:0011012)3.12609475
54Abnormality of glycosaminoglycan metabolism (HP:0004371)3.12609475
55Abnormality of mucopolysaccharide metabolism (HP:0011020)3.12609475
56Dysostosis multiplex (HP:0000943)3.10943846
57Recurrent abscess formation (HP:0002722)3.05456920
58Polycythemia (HP:0001901)3.04263305
59Elevated erythrocyte sedimentation rate (HP:0003565)3.03856555
60Short chin (HP:0000331)3.03313931
61Anteriorly placed anus (HP:0001545)3.03076015
62Ragged-red muscle fibers (HP:0003200)2.99327157
63Recurrent bacterial skin infections (HP:0005406)2.99167955
64Growth hormone excess (HP:0000845)2.94647384
65Seborrheic dermatitis (HP:0001051)2.93343515
66Alacrima (HP:0000522)2.92867061
67Hypochromic anemia (HP:0001931)2.92152292
68Autoimmune thrombocytopenia (HP:0001973)2.91944023
69Acute encephalopathy (HP:0006846)2.91279542
70Premature skin wrinkling (HP:0100678)2.90927922
71Squamous cell carcinoma (HP:0002860)2.90495561
72Petechiae (HP:0000967)2.88965436
73Autoimmune hemolytic anemia (HP:0001890)2.87794108
74Increased CSF lactate (HP:0002490)2.87248234
75Abnormal number of erythroid precursors (HP:0012131)2.84586959
76Abnormality of the aortic arch (HP:0012303)2.84384582
77Congenital hip dislocation (HP:0001374)2.82666436
78Granulocytopenia (HP:0001913)2.81691561
79Absent thumb (HP:0009777)2.81456984
80Abnormality of cells of the erythroid lineage (HP:0012130)2.79752224
81Asymmetric septal hypertrophy (HP:0001670)2.78182883
82Hypokinesia (HP:0002375)2.76700906
83Joint stiffness (HP:0001387)2.70313042
84Meningitis (HP:0001287)2.70274265
85Basal cell carcinoma (HP:0002671)2.68506535
86Absent radius (HP:0003974)2.66867928
87Hyperthyroidism (HP:0000836)2.64925485
88Ketoacidosis (HP:0001993)2.64378853
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59168721
90Broad alveolar ridges (HP:0000187)2.57994260
91Exertional dyspnea (HP:0002875)2.56053064
92Recurrent viral infections (HP:0004429)2.55784787
93Abnormality of T cells (HP:0002843)2.54806685
94Lactic acidosis (HP:0003128)2.52404570
95Microretrognathia (HP:0000308)2.52174369
96Redundant skin (HP:0001582)2.52132799
97Absent forearm bone (HP:0003953)2.49778313
98Aplasia involving forearm bones (HP:0009822)2.49778313
99Clumsiness (HP:0002312)2.45261747
100Truncus arteriosus (HP:0001660)2.44805551
101Colitis (HP:0002583)2.43377948
102Cerebral palsy (HP:0100021)2.43111358
103Increased serum lactate (HP:0002151)2.42442455
104Muscle fiber atrophy (HP:0100295)2.41691589
105Hypotrichosis (HP:0001006)2.41194389
106Hamartoma (HP:0010566)2.40326819
107Choanal stenosis (HP:0000452)2.40144861
108Cellulitis (HP:0100658)2.38109989
109Stomatitis (HP:0010280)2.37571297
110Exercise intolerance (HP:0003546)2.37083451
111Recurrent fungal infections (HP:0002841)2.36719277
112Premature graying of hair (HP:0002216)2.36154241
113Lipid accumulation in hepatocytes (HP:0006561)2.36063633
114Bifid uvula (HP:0000193)2.35775025
115Aplasia/Hypoplasia of the thymus (HP:0010515)2.34689191
116Generalized amyotrophy (HP:0003700)2.34481990
117Bowed forearm bones (HP:0003956)2.32719161
118Bowing of the arm (HP:0006488)2.32719161
119Bulbar palsy (HP:0001283)2.32715320
120Mediastinal lymphadenopathy (HP:0100721)2.31656862
121Progressive macrocephaly (HP:0004481)2.30837675
122Abnormality of the pancreatic islet cells (HP:0006476)2.29708591
123Abnormality of endocrine pancreas physiology (HP:0012093)2.29708591
124Hepatosplenomegaly (HP:0001433)2.29592117
125Selective tooth agenesis (HP:0001592)2.27709550
126Capillary hemangiomas (HP:0005306)2.27681835
127Lower limb hyperreflexia (HP:0002395)2.27472015
128Hypobetalipoproteinemia (HP:0003563)2.27442256
129Type 2 muscle fiber atrophy (HP:0003554)2.26785235
130Type I transferrin isoform profile (HP:0003642)2.25012061
131Amelogenesis imperfecta (HP:0000705)2.24489370
132Aplasia of the musculature (HP:0100854)2.23860573
133IgA deficiency (HP:0002720)2.23588468
134Cerebral edema (HP:0002181)2.22861073
135Thrombocytosis (HP:0001894)2.22056525
136Abnormality of the heme biosynthetic pathway (HP:0010472)2.21233035
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20374050
138Hypergammaglobulinemia (HP:0010702)2.19935409
139Increased serum ferritin (HP:0003281)2.19373968
140Renal Fanconi syndrome (HP:0001994)2.17526601
141Eosinophilia (HP:0001880)2.17329632
142Recurrent skin infections (HP:0001581)2.17168654
143Increased hepatocellular lipid droplets (HP:0006565)2.17085073
144Dicarboxylic aciduria (HP:0003215)2.16993616
145Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16993616
146Eczematoid dermatitis (HP:0000976)2.16733578
147Respiratory failure (HP:0002878)2.14841873
148Aplastic anemia (HP:0001915)2.14769131
149Abnormality of the columella (HP:0009929)2.14530831
150Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14475125
151Urticaria (HP:0001025)2.14443293
152Patellar aplasia (HP:0006443)2.14407299
153Exercise-induced myalgia (HP:0003738)2.13097165
154Decreased lacrimation (HP:0000633)2.12559320
155Purpura (HP:0000979)2.12505635
156Neutropenia (HP:0001875)2.12494147
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12123737
158Abnormal protein N-linked glycosylation (HP:0012347)2.12123737
159Abnormal protein glycosylation (HP:0012346)2.12123737
160Abnormal glycosylation (HP:0012345)2.12123737
161Progressive muscle weakness (HP:0003323)2.10112675
162Gastrointestinal inflammation (HP:0004386)2.08900435
163Birth length less than 3rd percentile (HP:0003561)2.08683400
164Abnormality of the prostate (HP:0008775)2.07218681
165Myositis (HP:0100614)2.05778645
166Amniotic constriction ring (HP:0009775)2.05681234
167Abnormality of placental membranes (HP:0011409)2.05681234
168Emotional lability (HP:0000712)2.04267557
169Testicular atrophy (HP:0000029)2.04000584
170Hypercortisolism (HP:0001578)2.03449585
171Hypoplasia of the radius (HP:0002984)2.02735393
172Hypotelorism (HP:0000601)2.02381150
173Opisthotonus (HP:0002179)2.01654254
174Ketosis (HP:0001946)2.01432485
175Reticulocytopenia (HP:0001896)1.99549640
1763-Methylglutaconic aciduria (HP:0003535)1.98183769
177Encephalitis (HP:0002383)1.97880331
178Increased neuronal autofluorescent lipopigment (HP:0002074)1.97556403
179Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97556002
180Popliteal pterygium (HP:0009756)1.97409553
181Acute lymphatic leukemia (HP:0006721)1.95904848
182Multiple enchondromatosis (HP:0005701)1.95718915
183Chronic mucocutaneous candidiasis (HP:0002728)1.94642635
184Recurrent cutaneous fungal infections (HP:0011370)1.94642635
185Pallor (HP:0000980)1.94051230
186Aplasia/Hypoplasia of the patella (HP:0006498)1.93889641
187Skin rash (HP:0000988)1.92725567
188Volvulus (HP:0002580)1.92715639
189Viral hepatitis (HP:0006562)1.92147042
190Abnormal gallbladder physiology (HP:0012438)1.91578916
191Cholecystitis (HP:0001082)1.91578916
192Rough bone trabeculation (HP:0100670)1.91121287
193Inflammation of the large intestine (HP:0002037)1.90688465
194Hyperammonemia (HP:0001987)1.90042320
195Gastrointestinal dysmotility (HP:0002579)1.89336994
196Myoglobinuria (HP:0002913)1.88743274
197Vertebral compression fractures (HP:0002953)1.87785072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.86735562
2MAPK155.46230421
3DDR24.69913174
4MAP3K64.64324200
5VRK24.62976833
6MAP3K113.84822410
7PINK13.83535361
8SMG13.23204955
9TESK23.15724086
10MATK3.11434983
11TYRO32.81777541
12FGR2.74738564
13PIM22.72511144
14DAPK12.62478972
15TESK12.28456822
16PRKD22.21230650
17UHMK12.20852665
18DYRK1B2.11594331
19ERN12.10045432
20IRAK32.09273778
21MAP2K32.06723158
22CSK2.05294429
23BMX2.04629834
24YES12.00716462
25PDGFRA1.98620773
26TAOK31.94395105
27GRK61.86207611
28SCYL21.83313318
29CDK71.68252740
30TBK11.48252269
31TRPM71.47188434
32CDK191.45487832
33PIM11.42892042
34RPS6KL11.34810092
35RPS6KC11.34810092
36CDK61.34167543
37AKT31.32584687
38PHKG11.32120715
39PHKG21.32120715
40BCKDK1.31407973
41KIT1.24981462
42MAPK111.23481312
43ARAF1.19261079
44RPS6KA61.17790133
45FES1.17300946
46TYK21.16910318
47RIPK41.14331043
48VRK11.14258291
49NME11.13093468
50LATS21.12614170
51CDC42BPA1.05762269
52GSK3A1.04133227
53DYRK31.02672037
54BTK1.00907428
55CSNK1G31.00708271
56TAF10.98732482
57IKBKB0.97685980
58BUB10.89907552
59IRAK40.88809290
60CHEK20.87504522
61SYK0.87079738
62JAK30.84830638
63HIPK20.83697836
64ZAP700.83365477
65TAOK20.83097235
66RPS6KA50.82533567
67LRRK20.81284142
68MAP3K100.80834546
69RPS6KA40.80756664
70NME20.79966774
71PRKD30.79405362
72ABL20.78746382
73DAPK30.77090304
74TXK0.75603033
75ZAK0.75405591
76TRIB30.75131661
77STK160.74764710
78BLK0.73685715
79NUAK10.72473367
80PRKAA10.71009765
81PLK10.70709295
82CDC70.69492047
83RPS6KA10.68510520
84SIK10.67942530
85IKBKE0.67892900
86RPS6KB20.63365151
87CSNK1A1L0.62539340
88CSF1R0.62333462
89GRK50.62296038
90MAP2K60.62028759
91RAF10.61223148
92MTOR0.56319499
93BMPR20.55416196
94MAPK120.55276570
95MAP3K30.54432832
96MAP4K20.53538303
97ITK0.52964816
98FLT30.51484372
99BRAF0.51466903
100CAMK2G0.51244134
101LYN0.51179615
102PIK3CA0.50838186
103PDK20.49157019
104TEC0.47818854
105CSNK2A10.47661622
106MAPK40.45731930
107MAPKAPK30.44932547
108PAK10.44135663
109ATR0.42267732
110PRPF4B0.42143666
111EGFR0.42128659
112SRPK10.42060073
113IRAK20.41528921
114PRKAA20.41162282
115AURKA0.39672698
116MAP3K10.39670340
117TNK20.39443728
118HCK0.39083309
119STK100.38995084
120EIF2AK20.38813418
121MAPK30.38544744
122CSNK1G20.38104115
123SIK30.37241460
124MAP3K80.37202016
125NEK10.36085804
126RPS6KB10.35714819
127CDK20.33462269
128WEE10.33409554
129CAMK2B0.33319142
130CSNK2A20.33220045
131MAP4K10.32106579
132CAMK2D0.30966882
133STK40.29309194
134MAPK10.28082310
135CSNK1G10.27339090
136DYRK20.27221339
137ERBB30.24341975
138MAPKAPK20.23765719
139CDK80.23691649
140PDGFRB0.21904127
141PRKCD0.21132311
142NEK20.20521257
143PRKD10.20240718
144AURKB0.20224087
145CDK40.20044732
146CAMK2A0.19313836
147KDR0.18286863
148MAPK140.16763691
149PRKCZ0.16094647
150EPHA20.15243194
151LCK0.14833883
152JAK20.14813665
153ATM0.14044241
154INSR0.13799576
155MAPK100.13407671
156PRKACG0.13090369
157TAOK10.12834592
158TLK10.12139516
159BRSK20.11831131
160PAK20.11117522
161AKT20.10471503
162MAP3K90.09915131
163CHEK10.08812616
164AKT10.07698878
165ILK0.07588387
166CDK10.07412570

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.09858760
2Mismatch repair_Homo sapiens_hsa034304.44096245
3Base excision repair_Homo sapiens_hsa034104.34707256
4DNA replication_Homo sapiens_hsa030303.64938245
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.90035829
6Allograft rejection_Homo sapiens_hsa053302.32060028
7Arginine and proline metabolism_Homo sapiens_hsa003302.25432898
8Fatty acid metabolism_Homo sapiens_hsa012122.24818566
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.19199404
10Biosynthesis of amino acids_Homo sapiens_hsa012302.19066060
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13700118
12Nucleotide excision repair_Homo sapiens_hsa034202.11001101
13Autoimmune thyroid disease_Homo sapiens_hsa053202.10382391
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09486273
15Sulfur relay system_Homo sapiens_hsa041222.06991618
16Ribosome_Homo sapiens_hsa030102.05743541
17Folate biosynthesis_Homo sapiens_hsa007902.04050450
18Graft-versus-host disease_Homo sapiens_hsa053321.92934384
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75932150
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75564057
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.75316097
22Circadian rhythm_Homo sapiens_hsa047101.70288056
23Other glycan degradation_Homo sapiens_hsa005111.66521841
24Asthma_Homo sapiens_hsa053101.65887420
25Spliceosome_Homo sapiens_hsa030401.63491517
26Homologous recombination_Homo sapiens_hsa034401.58673684
27Arginine biosynthesis_Homo sapiens_hsa002201.56281324
28Type I diabetes mellitus_Homo sapiens_hsa049401.52967980
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.43106845
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42982038
31Notch signaling pathway_Homo sapiens_hsa043301.41732707
32RNA transport_Homo sapiens_hsa030131.39618086
33Fructose and mannose metabolism_Homo sapiens_hsa000511.39002049
34mTOR signaling pathway_Homo sapiens_hsa041501.37402366
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.35007014
36Fanconi anemia pathway_Homo sapiens_hsa034601.27637273
37Antigen processing and presentation_Homo sapiens_hsa046121.26041758
38Propanoate metabolism_Homo sapiens_hsa006401.23890024
39Systemic lupus erythematosus_Homo sapiens_hsa053221.21986638
40Herpes simplex infection_Homo sapiens_hsa051681.21619804
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20666016
42mRNA surveillance pathway_Homo sapiens_hsa030151.20241335
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19447851
44Hedgehog signaling pathway_Homo sapiens_hsa043401.15442429
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15015781
46p53 signaling pathway_Homo sapiens_hsa041151.12195147
47Lysine degradation_Homo sapiens_hsa003101.10367782
48Leishmaniasis_Homo sapiens_hsa051401.08959613
49Hippo signaling pathway_Homo sapiens_hsa043901.07478130
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06208313
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04383006
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00880826
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98949911
54Carbon metabolism_Homo sapiens_hsa012000.97563800
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97513127
56Galactose metabolism_Homo sapiens_hsa000520.97301866
57Epstein-Barr virus infection_Homo sapiens_hsa051690.95616520
58Vitamin B6 metabolism_Homo sapiens_hsa007500.94572274
59Adherens junction_Homo sapiens_hsa045200.94308071
60Fatty acid elongation_Homo sapiens_hsa000620.91563348
61Fatty acid degradation_Homo sapiens_hsa000710.91078895
62Purine metabolism_Homo sapiens_hsa002300.89149120
63Bladder cancer_Homo sapiens_hsa052190.86738255
64B cell receptor signaling pathway_Homo sapiens_hsa046620.86248518
65Non-homologous end-joining_Homo sapiens_hsa034500.86183130
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85497121
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85008594
68Rheumatoid arthritis_Homo sapiens_hsa053230.84324593
69Glutathione metabolism_Homo sapiens_hsa004800.84098463
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82577949
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.81741694
72Pyruvate metabolism_Homo sapiens_hsa006200.81236070
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80951055
74Parkinsons disease_Homo sapiens_hsa050120.80152959
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.80113589
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79334473
77Measles_Homo sapiens_hsa051620.78272491
78Proteasome_Homo sapiens_hsa030500.77173820
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75945896
80Cell cycle_Homo sapiens_hsa041100.74138485
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.72796035
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72226101
83Influenza A_Homo sapiens_hsa051640.71282710
84Hematopoietic cell lineage_Homo sapiens_hsa046400.70397536
85Tuberculosis_Homo sapiens_hsa051520.68626269
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68502517
87Primary immunodeficiency_Homo sapiens_hsa053400.68498316
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.67522434
89Shigellosis_Homo sapiens_hsa051310.67412529
90Starch and sucrose metabolism_Homo sapiens_hsa005000.67043914
91TGF-beta signaling pathway_Homo sapiens_hsa043500.66457541
92N-Glycan biosynthesis_Homo sapiens_hsa005100.66195089
93One carbon pool by folate_Homo sapiens_hsa006700.66022128
94Oxidative phosphorylation_Homo sapiens_hsa001900.64704756
95Huntingtons disease_Homo sapiens_hsa050160.64207032
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.63977470
97Pyrimidine metabolism_Homo sapiens_hsa002400.63372855
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62060225
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61540288
100Tryptophan metabolism_Homo sapiens_hsa003800.60445308
101Selenocompound metabolism_Homo sapiens_hsa004500.59532539
102Apoptosis_Homo sapiens_hsa042100.58997504
103African trypanosomiasis_Homo sapiens_hsa051430.58524169
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58325588
105Sulfur metabolism_Homo sapiens_hsa009200.57944405
106Wnt signaling pathway_Homo sapiens_hsa043100.57851121
107Lysosome_Homo sapiens_hsa041420.55732789
108Osteoclast differentiation_Homo sapiens_hsa043800.54979468
109Staphylococcus aureus infection_Homo sapiens_hsa051500.54730707
110VEGF signaling pathway_Homo sapiens_hsa043700.52447000
111Peroxisome_Homo sapiens_hsa041460.50331123
112HTLV-I infection_Homo sapiens_hsa051660.49270265
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49227025
114AMPK signaling pathway_Homo sapiens_hsa041520.47717367
115Cardiac muscle contraction_Homo sapiens_hsa042600.47562776
116Non-small cell lung cancer_Homo sapiens_hsa052230.45823205
117Phenylalanine metabolism_Homo sapiens_hsa003600.45786214
118Metabolic pathways_Homo sapiens_hsa011000.45299740
119Hepatitis B_Homo sapiens_hsa051610.44898064
120Basal cell carcinoma_Homo sapiens_hsa052170.44764222
121Fat digestion and absorption_Homo sapiens_hsa049750.44504398
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43736347
123Pentose phosphate pathway_Homo sapiens_hsa000300.43352050
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42739318
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42615761
126beta-Alanine metabolism_Homo sapiens_hsa004100.41802563
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41672148
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41654423
129RNA polymerase_Homo sapiens_hsa030200.40914467
130Insulin signaling pathway_Homo sapiens_hsa049100.40428960
131Viral carcinogenesis_Homo sapiens_hsa052030.40354519
132Salmonella infection_Homo sapiens_hsa051320.37393169
133Toxoplasmosis_Homo sapiens_hsa051450.36517995
134Legionellosis_Homo sapiens_hsa051340.36099843
135Acute myeloid leukemia_Homo sapiens_hsa052210.35120406
136T cell receptor signaling pathway_Homo sapiens_hsa046600.34512964
137Tyrosine metabolism_Homo sapiens_hsa003500.34506978
138Caffeine metabolism_Homo sapiens_hsa002320.31105423
139Viral myocarditis_Homo sapiens_hsa054160.31077027
140Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29772207
141Thyroid cancer_Homo sapiens_hsa052160.29597771
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.29126158
143PPAR signaling pathway_Homo sapiens_hsa033200.29106432
144Oocyte meiosis_Homo sapiens_hsa041140.28544259
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26943290
146Alzheimers disease_Homo sapiens_hsa050100.21562564
147RNA degradation_Homo sapiens_hsa030180.21171318
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20228759
149Butanoate metabolism_Homo sapiens_hsa006500.20067282
150Colorectal cancer_Homo sapiens_hsa052100.19326079

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