OXGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)8.91531337
2drug transmembrane transport (GO:0006855)8.89830942
3organic cation transport (GO:0015695)7.96490095
4drug transport (GO:0015893)7.62096529
5sphingosine metabolic process (GO:0006670)7.43664214
6cilium or flagellum-dependent cell motility (GO:0001539)7.33658882
7diol metabolic process (GO:0034311)6.70650598
8phosphate ion transport (GO:0006817)6.66042686
9lysine metabolic process (GO:0006553)6.43155710
10lysine catabolic process (GO:0006554)6.43155710
11sphingoid metabolic process (GO:0046519)6.20024505
12cilium movement (GO:0003341)6.19264219
13quaternary ammonium group transport (GO:0015697)5.94706892
14nonribosomal peptide biosynthetic process (GO:0019184)5.89384527
15drug catabolic process (GO:0042737)5.82134698
16exogenous drug catabolic process (GO:0042738)5.80408172
17excretion (GO:0007588)5.79116605
18phosphate ion transmembrane transport (GO:0035435)5.35194080
19axonemal dynein complex assembly (GO:0070286)5.33856452
20renal absorption (GO:0070293)5.31498300
21nucleoside diphosphate phosphorylation (GO:0006165)5.17458640
22fructose metabolic process (GO:0006000)5.14246020
23response to mercury ion (GO:0046689)5.12545266
24glycoside metabolic process (GO:0016137)5.08639116
25toxin transport (GO:1901998)4.96316552
26aspartate family amino acid catabolic process (GO:0009068)4.92891873
27epithelial cilium movement (GO:0003351)4.90850186
28phosphate ion homeostasis (GO:0055062)4.78565061
29trivalent inorganic anion homeostasis (GO:0072506)4.78565061
30cysteine metabolic process (GO:0006534)4.74662275
31peptide biosynthetic process (GO:0043043)4.73890879
32regulation of meiosis I (GO:0060631)4.67097468
33glyoxylate metabolic process (GO:0046487)4.66825726
34glutathione biosynthetic process (GO:0006750)4.58950616
35modified amino acid transport (GO:0072337)4.56567157
36vitamin D metabolic process (GO:0042359)4.55391554
37UDP-N-acetylglucosamine metabolic process (GO:0006047)4.51937181
38metanephric nephron tubule development (GO:0072234)4.49430214
39metanephric tubule development (GO:0072170)4.49430214
40amino-acid betaine transport (GO:0015838)4.40758892
41carnitine transport (GO:0015879)4.40758892
42short-chain fatty acid metabolic process (GO:0046459)4.33719475
43protein-chromophore linkage (GO:0018298)4.32047393
44branched-chain amino acid metabolic process (GO:0009081)4.29596766
45negative regulation of glycogen metabolic process (GO:0070874)4.29065888
46paraxial mesoderm development (GO:0048339)4.20505641
47axoneme assembly (GO:0035082)4.19041522
48endocrine pancreas development (GO:0031018)4.18887205
49regulation of protein glycosylation (GO:0060049)4.14900838
50GTP biosynthetic process (GO:0006183)4.14155841
51response to parathyroid hormone (GO:0071107)4.07945889
52serine family amino acid metabolic process (GO:0009069)4.07510882
53serine family amino acid catabolic process (GO:0009071)4.03042669
54metanephric nephron epithelium development (GO:0072243)4.02127594
55polyol catabolic process (GO:0046174)4.01909684
56ventricular system development (GO:0021591)4.00782110
57negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.98278765
58proline metabolic process (GO:0006560)3.95101058
59nodal signaling pathway (GO:0038092)3.92135231
60branched-chain amino acid catabolic process (GO:0009083)3.92046703
61amino-acid betaine metabolic process (GO:0006577)3.89561039
62DNA methylation involved in gamete generation (GO:0043046)3.82866423
63homocysteine metabolic process (GO:0050667)3.82226136
64kidney morphogenesis (GO:0060993)3.81893529
65positive regulation of meiosis (GO:0045836)3.81400062
66regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.76569746
67oligosaccharide catabolic process (GO:0009313)3.75059568
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.74467823
69nephron epithelium morphogenesis (GO:0072088)3.69192553
70nephron tubule morphogenesis (GO:0072078)3.69192553
71lactate metabolic process (GO:0006089)3.66974733
72metanephric epithelium development (GO:0072207)3.66637592
73heme transport (GO:0015886)3.64444103
74sulfate transmembrane transport (GO:1902358)3.63690833
75positive regulation of meiotic cell cycle (GO:0051446)3.58987559
76glutathione derivative biosynthetic process (GO:1901687)3.58957839
77glutathione derivative metabolic process (GO:1901685)3.58957839
78proline transport (GO:0015824)3.57639948
79alditol metabolic process (GO:0019400)3.51053352
80UTP biosynthetic process (GO:0006228)3.50617958
81ADP metabolic process (GO:0046031)3.50527761
82sulfur compound transport (GO:0072348)3.49987037
83bicarbonate transport (GO:0015701)3.48303781
84regulation of cilium movement (GO:0003352)3.46059011
85acrosome reaction (GO:0007340)3.45721887
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.44209577
87fatty acid beta-oxidation (GO:0006635)3.43823426
88positive regulation of respiratory burst (GO:0060267)3.41665989
89regulation of nuclear cell cycle DNA replication (GO:0033262)3.41387440
90polyol transport (GO:0015791)3.40460640
91lipopolysaccharide biosynthetic process (GO:0009103)3.38890488
92aromatic amino acid family catabolic process (GO:0009074)3.37582728
93carnitine metabolic process (GO:0009437)3.37322925
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36731481
95L-phenylalanine metabolic process (GO:0006558)3.36731481
96serine family amino acid biosynthetic process (GO:0009070)3.36311777
97tricarboxylic acid metabolic process (GO:0072350)3.36150251
98inositol metabolic process (GO:0006020)3.35569387
99cellular ketone body metabolic process (GO:0046950)3.33455577
100rRNA modification (GO:0000154)3.31502159
101regulation of hexokinase activity (GO:1903299)3.27843547
102regulation of glucokinase activity (GO:0033131)3.27843547
103rRNA methylation (GO:0031167)3.27241244
104indole-containing compound catabolic process (GO:0042436)3.26802847
105indolalkylamine catabolic process (GO:0046218)3.26802847
106tryptophan catabolic process (GO:0006569)3.26802847
107UTP metabolic process (GO:0046051)3.26206265
108phosphorelay signal transduction system (GO:0000160)3.24973378
109glutathione metabolic process (GO:0006749)3.24100067
110sodium ion transport (GO:0006814)3.23384148
111negative regulation of cell cycle G2/M phase transition (GO:1902750)3.22404307
112valine metabolic process (GO:0006573)3.22013683
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.18384274
114L-phenylalanine catabolic process (GO:0006559)3.18384274
115water-soluble vitamin biosynthetic process (GO:0042364)3.17386892
116nephron tubule development (GO:0072080)3.17015322
117indole-containing compound metabolic process (GO:0042430)3.15962471
118sulfate transport (GO:0008272)3.13940334
119notochord development (GO:0030903)3.13689784
120guanosine-containing compound biosynthetic process (GO:1901070)3.08831088
121nucleotide phosphorylation (GO:0046939)3.08437201
122vitamin transport (GO:0051180)3.07888548
123NADH metabolic process (GO:0006734)3.06929145
124CTP biosynthetic process (GO:0006241)3.06087005
125CTP metabolic process (GO:0046036)3.06087005
126regulation of non-canonical Wnt signaling pathway (GO:2000050)3.05737469
127cellular response to vitamin D (GO:0071305)3.03815063
128regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.03500141
129bundle of His cell to Purkinje myocyte communication (GO:0086069)3.03478107
130response to magnesium ion (GO:0032026)3.02704385
131tryptophan metabolic process (GO:0006568)3.02689690
132tricarboxylic acid cycle (GO:0006099)3.02681527
133biotin metabolic process (GO:0006768)3.01719467
134folic acid transport (GO:0015884)3.00269675
135positive regulation of protein autophosphorylation (GO:0031954)2.99078174
136piRNA metabolic process (GO:0034587)2.98043637
137regulation of rhodopsin mediated signaling pathway (GO:0022400)2.92767798
138lipopolysaccharide metabolic process (GO:0008653)2.92526426
139negative regulation of hormone biosynthetic process (GO:0032353)2.90840735
140alanine transport (GO:0032328)2.88013760
141negative regulation of glycogen biosynthetic process (GO:0045719)2.87337904
142negative regulation of norepinephrine secretion (GO:0010700)2.82958321
143regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.78907799
144negative regulation of neurological system process (GO:0031645)2.78571785
145dicarboxylic acid catabolic process (GO:0043649)2.77168078
146centriole replication (GO:0007099)2.74551052
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.73450313
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.73450313
149cell wall macromolecule catabolic process (GO:0016998)2.72230321
150rhodopsin mediated signaling pathway (GO:0016056)2.70153883
151righting reflex (GO:0060013)2.67982464
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.67112838
153negative regulation of DNA-dependent DNA replication (GO:2000104)2.66132832
154serotonin metabolic process (GO:0042428)2.64928433
155positive regulation of glycogen biosynthetic process (GO:0045725)2.63346631
156positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.61100850
157exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59906759
158regulation of heart rate by cardiac conduction (GO:0086091)2.58779507
159membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.58297070
160negative regulation of acute inflammatory response (GO:0002674)2.57942709
161iron coordination entity transport (GO:1901678)2.57811598
162protein K6-linked ubiquitination (GO:0085020)2.56855604
163tyrosine metabolic process (GO:0006570)2.56667719
164signal peptide processing (GO:0006465)2.55864027
165regulation of uterine smooth muscle contraction (GO:0070472)2.54434672
166negative regulation of gluconeogenesis (GO:0045721)2.54202651
167positive regulation of glucose metabolic process (GO:0010907)2.53922832
168reflex (GO:0060004)2.53695336
169negative regulation of catecholamine secretion (GO:0033604)2.52480242
170insulin secretion (GO:0030073)2.52250453
171meiotic chromosome segregation (GO:0045132)2.51139204
172nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50468383
173inositol phosphate catabolic process (GO:0071545)2.48715666
174negative regulation of insulin secretion (GO:0046676)2.48025740
175positive regulation of glycolytic process (GO:0045821)2.45503520
176positive regulation of glycogen metabolic process (GO:0070875)2.44696850
177negative regulation of hormone metabolic process (GO:0032351)2.43294565
178organ induction (GO:0001759)2.42532784
179negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40986197
180regulation of mesoderm development (GO:2000380)2.40806543
181inositol phosphate dephosphorylation (GO:0046855)2.40801712
182phosphorylated carbohydrate dephosphorylation (GO:0046838)2.40801712
183response to nitrosative stress (GO:0051409)2.39445787
184tetrahydrofolate metabolic process (GO:0046653)2.38094966
185ribonucleoprotein complex disassembly (GO:0032988)2.37145625
186regulation of metanephros development (GO:0072215)2.36396964
187dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.35079683
188negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.33142294
189regulation of energy homeostasis (GO:2000505)2.32387593
190chromatin remodeling at centromere (GO:0031055)2.32170403
191ovulation cycle (GO:0042698)2.30938089
192regulation of glycogen biosynthetic process (GO:0005979)2.30666662
193regulation of glucan biosynthetic process (GO:0010962)2.30666662
194aminoglycoside antibiotic metabolic process (GO:0030647)11.2074075

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.54963360
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.35024611
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.32834824
4VDR_22108803_ChIP-Seq_LS180_Human3.26075526
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92364764
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.86651273
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.68768682
8AR_21909140_ChIP-Seq_LNCAP_Human2.42536657
9AR_21572438_ChIP-Seq_LNCaP_Human2.42361907
10FUS_26573619_Chip-Seq_HEK293_Human2.29672711
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27034138
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17625465
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.14832420
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.07647381
15NFE2_27457419_Chip-Seq_LIVER_Mouse2.03723387
16GBX2_23144817_ChIP-Seq_PC3_Human1.90186834
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88708072
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.88522147
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87885831
20EZH2_22144423_ChIP-Seq_EOC_Human1.84696120
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80285831
22TAF15_26573619_Chip-Seq_HEK293_Human1.79738202
23KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74792374
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67469558
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65627936
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64952778
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61726289
28* PIAS1_25552417_ChIP-Seq_VCAP_Human1.61654280
29ZNF274_21170338_ChIP-Seq_K562_Hela1.61406934
30ER_23166858_ChIP-Seq_MCF-7_Human1.60737192
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60605644
32EWS_26573619_Chip-Seq_HEK293_Human1.58943097
33RNF2_27304074_Chip-Seq_NSC_Mouse1.53356433
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.52443746
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51763479
36IGF1R_20145208_ChIP-Seq_DFB_Human1.51511794
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50622907
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50328277
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46953978
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45704922
41STAT1_17558387_ChIP-Seq_HELA_Human1.44656520
42GATA1_26923725_Chip-Seq_HPCs_Mouse1.41398912
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40742137
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.40742137
45OCT4_18555785_Chip-Seq_ESCs_Mouse1.38141765
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.37705694
47ZFX_18555785_Chip-Seq_ESCs_Mouse1.36749812
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.36678731
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35277970
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.34416682
51STAT3_23295773_ChIP-Seq_U87_Human1.34031192
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.32428271
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31055987
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30741535
55AR_25329375_ChIP-Seq_VCAP_Human1.28823501
56ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28672458
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28581952
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26178672
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.24329282
60RUNX1_27457419_Chip-Seq_LIVER_Mouse1.23470496
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23382327
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.22992514
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22841012
64* SMAD3_21741376_ChIP-Seq_ESCs_Human1.22818570
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22481680
66TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22371556
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21754810
68TCF4_23295773_ChIP-Seq_U87_Human1.21051460
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19670945
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.18525857
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18463312
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18302054
73SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17928173
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.17893942
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17544358
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.17504817
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17358699
78P300_18555785_Chip-Seq_ESCs_Mouse1.16417526
79P53_22387025_ChIP-Seq_ESCs_Mouse1.15809116
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.15758084
81SMAD4_21799915_ChIP-Seq_A2780_Human1.15684773
82GF1B_26923725_Chip-Seq_HPCs_Mouse1.15404504
83EST1_17652178_ChIP-ChIP_JURKAT_Human1.15176008
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14125341
85RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13891998
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13807920
87TCF4_22108803_ChIP-Seq_LS180_Human1.13003668
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12222732
89HOXB7_26014856_ChIP-Seq_BT474_Human1.11191081
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10852321
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.10850606
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10714290
93* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10543778
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.10423488
95GF1_26923725_Chip-Seq_HPCs_Mouse1.09001183
96EZH2_27304074_Chip-Seq_ESCs_Mouse1.07852011
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07729566
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.07476584
99SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07173162
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.07127446
101SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07105755
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.06444519
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05979136
104* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05656734
105ELK1_19687146_ChIP-ChIP_HELA_Human1.05410607
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05357786
107STAT3_18555785_ChIP-Seq_MESCs_Mouse1.05149292
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04550130
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04355527
110NCOR_22424771_ChIP-Seq_293T_Human1.04214241
111WDR5_24793694_ChIP-Seq_LNCAP_Human1.03860371
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03268202
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.03137201
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03099520
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03084509
116P300_19829295_ChIP-Seq_ESCs_Human1.03040931
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02843585
118NANOG_16153702_ChIP-ChIP_HESCs_Human1.02836688
119* NANOG_19829295_ChIP-Seq_ESCs_Human1.02709020
120* SOX2_19829295_ChIP-Seq_ESCs_Human1.02709020
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01803304
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01803046
123PHF8_20622853_ChIP-Seq_HELA_Human1.01747885
124* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01736668
125* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01736668
126RBPJ_21746931_ChIP-Seq_IB4_Human1.01275702
127BCAT_22108803_ChIP-Seq_LS180_Human1.01040079
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99554314
129EED_16625203_ChIP-ChIP_MESCs_Mouse0.99544114
130E2F7_22180533_ChIP-Seq_HELA_Human0.98515514
131YY1_21170310_ChIP-Seq_MESCs_Mouse0.98183109
132FOXH1_21741376_ChIP-Seq_EPCs_Human0.97779194
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97612059
134ETV1_20927104_ChIP-Seq_GIST48_Human0.97201425
135REST_21632747_ChIP-Seq_MESCs_Mouse0.96628903
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96544797
137CDX2_22108803_ChIP-Seq_LS180_Human0.96397584
138GATA3_21878914_ChIP-Seq_MCF-7_Human0.95471331
139SMAD3_21741376_ChIP-Seq_HESCs_Human0.95322669
140NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.95214745
141CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94876853
142PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94333314
143CTCF_18555785_Chip-Seq_ESCs_Mouse0.94174581
144E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93921231
145TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93917443
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93364957
147* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92452818
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91926616
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91342045
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90738710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation6.93746636
2MP0002837_dystrophic_cardiac_calcinosis6.51674132
3MP0005360_urolithiasis5.75882250
4MP0003136_yellow_coat_color5.35170298
5MP0004019_abnormal_vitamin_homeostasis4.84940598
6MP0005171_absent_coat_pigmentation4.82560998
7MP0005332_abnormal_amino_acid4.48115755
8MP0001765_abnormal_ion_homeostasis3.99410409
9MP0009643_abnormal_urine_homeostasis3.76431826
10MP0003195_calcinosis3.75455336
11MP0005377_hearing/vestibular/ear_phenot3.46679446
12MP0003878_abnormal_ear_physiology3.46679446
13MP0001756_abnormal_urination3.37583896
14MP0005636_abnormal_mineral_homeostasis3.23173051
15MP0003890_abnormal_embryonic-extraembry3.10290318
16MP0003123_paternal_imprinting3.06965453
17MP0003787_abnormal_imprinting2.99521733
18MP0002136_abnormal_kidney_physiology2.87622156
19MP0005379_endocrine/exocrine_gland_phen2.51429207
20MP0002139_abnormal_hepatobiliary_system2.48827206
21MP0002138_abnormal_hepatobiliary_system2.46485246
22MP0003045_fibrosis2.40164780
23MP0008875_abnormal_xenobiotic_pharmacok2.38178955
24MP0002876_abnormal_thyroid_physiology2.22375915
25MP0003186_abnormal_redox_activity2.13533815
26MP0002163_abnormal_gland_morphology2.11089603
27MP0000538_abnormal_urinary_bladder1.92067900
28MP0002938_white_spotting1.80328066
29MP0004885_abnormal_endolymph1.74461357
30MP0001958_emphysema1.73027518
31MP0009379_abnormal_foot_pigmentation1.69091312
32MP0010352_gastrointestinal_tract_polyps1.64723681
33MP0003693_abnormal_embryo_hatching1.58574336
34MP0003941_abnormal_skin_development1.57936279
35MP0003011_delayed_dark_adaptation1.52891159
36MP0006072_abnormal_retinal_apoptosis1.51774171
37MP0001764_abnormal_homeostasis1.51055857
38MP0010234_abnormal_vibrissa_follicle1.50025348
39MP0003646_muscle_fatigue1.50017697
40MP0002909_abnormal_adrenal_gland1.49940232
41MP0005075_abnormal_melanosome_morpholog1.44405196
42MP0004381_abnormal_hair_follicle1.44308165
43MP0005646_abnormal_pituitary_gland1.43696247
44MP0010678_abnormal_skin_adnexa1.41402307
45MP0000383_abnormal_hair_follicle1.39135584
46MP0005084_abnormal_gallbladder_morpholo1.36386116
47MP0003121_genomic_imprinting1.34486026
48MP0002653_abnormal_ependyma_morphology1.32359548
49MP0000230_abnormal_systemic_arterial1.31037615
50MP0005410_abnormal_fertilization1.30676386
51MP0001485_abnormal_pinna_reflex1.29613087
52MP0001188_hyperpigmentation1.27796362
53MP0006292_abnormal_olfactory_placode1.27724803
54MP0005365_abnormal_bile_salt1.26213211
55MP0005451_abnormal_body_composition1.24636818
56MP0001984_abnormal_olfaction1.23438663
57MP0002168_other_aberrant_phenotype1.22465028
58MP0002638_abnormal_pupillary_reflex1.21733129
59MP0008961_abnormal_basal_metabolism1.21109405
60MP0010386_abnormal_urinary_bladder1.19660565
61MP0003937_abnormal_limbs/digits/tail_de1.19194638
62MP0005085_abnormal_gallbladder_physiolo1.18575654
63MP0004142_abnormal_muscle_tone1.17658443
64MP0008877_abnormal_DNA_methylation1.17440410
65MP0006036_abnormal_mitochondrial_physio1.17357772
66MP0009046_muscle_twitch1.17228559
67MP0004742_abnormal_vestibular_system1.12856716
68MP0001501_abnormal_sleep_pattern1.12590416
69MP0001944_abnormal_pancreas_morphology1.12330533
70MP0005058_abnormal_lysosome_morphology1.11851798
71MP0005645_abnormal_hypothalamus_physiol1.11364041
72MP0005253_abnormal_eye_physiology1.10912700
73MP0000647_abnormal_sebaceous_gland1.10138020
74MP0002095_abnormal_skin_pigmentation1.09980063
75MP0002735_abnormal_chemical_nociception1.09715512
76MP0003252_abnormal_bile_duct1.09136286
77MP0003283_abnormal_digestive_organ1.08193036
78MP0005584_abnormal_enzyme/coenzyme_acti1.07754351
79MP0003119_abnormal_digestive_system1.07297606
80MP0003786_premature_aging1.05310948
81MP0002272_abnormal_nervous_system1.04548430
82MP0001324_abnormal_eye_pigmentation1.03661779
83MP0003638_abnormal_response/metabolism_1.01513779
84MP0002254_reproductive_system_inflammat1.01034622
85MP0005423_abnormal_somatic_nervous1.01033066
86MP0001486_abnormal_startle_reflex1.01027054
87MP0005395_other_phenotype0.99915361
88MP0005551_abnormal_eye_electrophysiolog0.99536456
89MP0003806_abnormal_nucleotide_metabolis0.98950386
90MP0003567_abnormal_fetal_cardiomyocyte0.97685057
91MP0002135_abnormal_kidney_morphology0.96339013
92MP0001286_abnormal_eye_development0.95737873
93MP0001186_pigmentation_phenotype0.95541832
94MP0003879_abnormal_hair_cell0.92878018
95MP0003122_maternal_imprinting0.91749952
96MP0002075_abnormal_coat/hair_pigmentati0.90664377
97MP0008057_abnormal_DNA_replication0.90661491
98MP0001963_abnormal_hearing_physiology0.90642126
99MP0003938_abnormal_ear_development0.90335978
100MP0001293_anophthalmia0.89895535
101MP0003698_abnormal_male_reproductive0.88975236
102MP0001440_abnormal_grooming_behavior0.88872780
103MP0008260_abnormal_autophagy0.87927912
104MP0002928_abnormal_bile_duct0.87437883
105MP0004858_abnormal_nervous_system0.87265885
106MP0004957_abnormal_blastocyst_morpholog0.86842179
107MP0002277_abnormal_respiratory_mucosa0.86296069
108MP0000026_abnormal_inner_ear0.85168779
109MP0005319_abnormal_enzyme/_coenzyme0.85051523
110MP0003718_maternal_effect0.84102012
111MP0005174_abnormal_tail_pigmentation0.83130476
112MP0002693_abnormal_pancreas_physiology0.81512083
113MP0001145_abnormal_male_reproductive0.80819382
114MP0000427_abnormal_hair_cycle0.80417902
115MP0005389_reproductive_system_phenotype0.80380798
116MP0001661_extended_life_span0.80148314
117MP0001663_abnormal_digestive_system0.79961972
118MP0002090_abnormal_vision0.79420994
119MP0002234_abnormal_pharynx_morphology0.79184456
120MP0002098_abnormal_vibrissa_morphology0.77552791
121MP0005670_abnormal_white_adipose0.77241811
122MP0002160_abnormal_reproductive_system0.75451477
123MP0000579_abnormal_nail_morphology0.75283284
124MP0001929_abnormal_gametogenesis0.74025103
125MP0004859_abnormal_synaptic_plasticity0.70097687
126MP0000678_abnormal_parathyroid_gland0.69966189
127MP0001968_abnormal_touch/_nociception0.68871430
128MP0002102_abnormal_ear_morphology0.67424825
129MP0002069_abnormal_eating/drinking_beha0.67137655
130MP0002132_abnormal_respiratory_system0.65882768
131MP0005535_abnormal_body_temperature0.65831512
132MP0005220_abnormal_exocrine_pancreas0.65175901
133MP0005195_abnormal_posterior_eye0.65137648
134MP0003137_abnormal_impulse_conducting0.64788385
135MP0005381_digestive/alimentary_phenotyp0.64160556
136MP0004270_analgesia0.64128299
137MP0009745_abnormal_behavioral_response0.63741650
138MP0004147_increased_porphyrin_level0.63366796
139MP0002229_neurodegeneration0.62849425
140MP0002734_abnormal_mechanical_nocicepti0.61301521
141MP0000653_abnormal_sex_gland0.61082903
142MP0002064_seizures0.60688539
143MP0006035_abnormal_mitochondrial_morpho0.60107649
144MP0002210_abnormal_sex_determination0.59993396
145MP0008872_abnormal_physiological_respon0.59764806
146MP0000631_abnormal_neuroendocrine_gland0.59512853
147MP0002736_abnormal_nociception_after0.59356091
148MP0001970_abnormal_pain_threshold0.59313315
149MP0000569_abnormal_digit_pigmentation0.57498924
150MP0002184_abnormal_innervation0.57277837
151MP0008932_abnormal_embryonic_tissue0.57223533
152MP0002557_abnormal_social/conspecific_i0.57222941
153MP0002896_abnormal_bone_mineralization0.57008508
154MP0009642_abnormal_blood_homeostasis0.56873125
155MP0005391_vision/eye_phenotype0.56747938
156MP0002089_abnormal_postnatal_growth/wei0.55944827
157MP0000377_abnormal_hair_follicle0.55651665
158MP0001270_distended_abdomen0.55564047
159MP0003953_abnormal_hormone_level0.55034971
160MP0002161_abnormal_fertility/fecundity0.54768818
161MP0002067_abnormal_sensory_capabilities0.54594328
162MP0009764_decreased_sensitivity_to0.54585106
163MP0003942_abnormal_urinary_system0.54577957
164MP0005165_increased_susceptibility_to0.53521710
165MP0003315_abnormal_perineum_morphology0.52566970
166MP0001542_abnormal_bone_strength0.51264487
167MP0002572_abnormal_emotion/affect_behav0.50118018

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.45857705
2Metabolic alkalosis (HP:0200114)7.02392074
3Hyperactive renin-angiotensin system (HP:0000841)6.97899202
4Hypomagnesemia (HP:0002917)6.55188768
5Polyuria (HP:0000103)6.53982311
6Hypokalemic alkalosis (HP:0001949)6.52078112
7Abnormality of chloride homeostasis (HP:0011422)6.33406390
8Abnormal urine output (HP:0012590)6.00485359
9Polydipsia (HP:0001959)5.79974993
10Abnormal drinking behavior (HP:0030082)5.79974993
11Abnormality of renal excretion (HP:0011036)5.66530449
12Hypoglycemic seizures (HP:0002173)5.64433018
13Abnormality of magnesium homeostasis (HP:0004921)5.62011121
14Gout (HP:0001997)5.40747821
15Abnormality of renin-angiotensin system (HP:0000847)4.99994421
16Hyperinsulinemic hypoglycemia (HP:0000825)4.98667225
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.86681389
18Proximal tubulopathy (HP:0000114)4.85787071
19Hyperaldosteronism (HP:0000859)4.71239968
20Tetany (HP:0001281)4.64189892
21Focal motor seizures (HP:0011153)4.54849820
22Hyperglycinuria (HP:0003108)4.50964025
23Alkalosis (HP:0001948)4.47367337
24Abnormal respiratory motile cilium physiology (HP:0012261)4.44936625
25Abnormal ciliary motility (HP:0012262)4.40523639
26Renal salt wasting (HP:0000127)4.30961216
27Hypoglycemic coma (HP:0001325)4.22075122
28Hyperuricemia (HP:0002149)4.12289320
29Increased purine levels (HP:0004368)4.12289320
30Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05914394
31Abnormality of the pancreatic islet cells (HP:0006476)3.90581968
32Abnormality of endocrine pancreas physiology (HP:0012093)3.90581968
33Neoplasm of the adrenal cortex (HP:0100641)3.78858851
34Abnormality of glycine metabolism (HP:0010895)3.78351245
35Abnormality of serine family amino acid metabolism (HP:0010894)3.78351245
36Amelogenesis imperfecta (HP:0000705)3.75731319
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.63338811
38Symptomatic seizures (HP:0011145)3.57777789
39Hypokalemia (HP:0002900)3.41825144
40Generalized aminoaciduria (HP:0002909)3.39764485
41Pancreatic islet-cell hyperplasia (HP:0004510)3.37679865
42Hydroxyprolinuria (HP:0003080)3.35653999
43Abnormality of proline metabolism (HP:0010907)3.35653999
44Abnormality of purine metabolism (HP:0004352)3.31485681
45Proximal amyotrophy (HP:0007126)3.24059964
46Hyperglycinemia (HP:0002154)3.23459617
47Rhinitis (HP:0012384)3.19077766
48Conjunctival hamartoma (HP:0100780)3.15297864
49Hypothermia (HP:0002045)3.14599455
50Hypercalciuria (HP:0002150)3.14315473
51Dialeptic seizures (HP:0011146)3.12383368
52Parakeratosis (HP:0001036)3.11378097
53Hypoplasia of the uterus (HP:0000013)3.09339704
54Abnormality of urine glucose concentration (HP:0011016)3.08873201
55Glycosuria (HP:0003076)3.08873201
56Late onset (HP:0003584)3.07514685
57Hematochezia (HP:0002573)2.97867929
58Abnormal respiratory motile cilium morphology (HP:0005938)2.96398298
59Abnormal respiratory epithelium morphology (HP:0012253)2.96398298
60Abnormality of potassium homeostasis (HP:0011042)2.95076563
61Acanthocytosis (HP:0001927)2.92792301
62Large for gestational age (HP:0001520)2.89046189
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.78521261
64Absent/shortened dynein arms (HP:0200106)2.78521261
65Pancreatic cysts (HP:0001737)2.75118219
66Tubular atrophy (HP:0000092)2.73356950
67Chronic bronchitis (HP:0004469)2.72500985
68Delayed epiphyseal ossification (HP:0002663)2.67413920
69Aplasia/hypoplasia of the uterus (HP:0008684)2.66429543
70Congenital stationary night blindness (HP:0007642)2.66352025
71Erythroderma (HP:0001019)2.64252453
72Renal tubular acidosis (HP:0001947)2.61313199
73Hyperglycemia (HP:0003074)2.59177997
74Hyperphosphaturia (HP:0003109)2.57494283
75Hepatoblastoma (HP:0002884)2.51613922
76Congenital ichthyosiform erythroderma (HP:0007431)2.50651868
77Neoplasm of the adrenal gland (HP:0100631)2.45981334
78Hyponatremia (HP:0002902)2.45599220
79Abnormality of nucleobase metabolism (HP:0010932)2.44743751
80Abnormality of sodium homeostasis (HP:0010931)2.44463251
81Methylmalonic acidemia (HP:0002912)2.42867476
82Abnormality of renal resorption (HP:0011038)2.42784852
83Woolly hair (HP:0002224)2.42457918
84Metaphyseal dysplasia (HP:0100255)2.42121545
85Abnormal urine phosphate concentration (HP:0012599)2.41532855
86Abnormality of fatty-acid metabolism (HP:0004359)2.37285066
87Ketoacidosis (HP:0001993)2.35478922
88Hyperventilation (HP:0002883)2.34662887
89Prominent metopic ridge (HP:0005487)2.31536736
90Tubulointerstitial fibrosis (HP:0005576)2.31099154
91Nephronophthisis (HP:0000090)2.30743733
92Pancreatic fibrosis (HP:0100732)2.30060331
93Molar tooth sign on MRI (HP:0002419)2.29998825
94Abnormality of midbrain morphology (HP:0002418)2.29998825
95Nephrocalcinosis (HP:0000121)2.27044109
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.26953556
97Enlarged penis (HP:0000040)2.24358887
98Hamartoma of the eye (HP:0010568)2.23797542
99Progressive macrocephaly (HP:0004481)2.23276981
100Pendular nystagmus (HP:0012043)2.19033590
101Methylmalonic aciduria (HP:0012120)2.16567941
102Colon cancer (HP:0003003)2.16535239
103Widely patent fontanelles and sutures (HP:0004492)2.16063327
104Bronchiectasis (HP:0002110)2.15798992
105Delayed CNS myelination (HP:0002188)2.15250626
106Dehydration (HP:0001944)2.15089454
107Aplastic anemia (HP:0001915)2.13892059
108Dicarboxylic aciduria (HP:0003215)2.11007780
109Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11007780
110Ketosis (HP:0001946)2.10892358
111Rectal fistula (HP:0100590)2.10727307
112Rectovaginal fistula (HP:0000143)2.10727307
113Adrenal overactivity (HP:0002717)2.07552465
114Pigmentary retinal degeneration (HP:0001146)2.04254271
115Abnormality of the renal medulla (HP:0100957)2.04004114
116Reticulocytopenia (HP:0001896)2.01899779
117Severe visual impairment (HP:0001141)2.01617328
118Abnormality of the metopic suture (HP:0005556)2.01276368
119Multiple enchondromatosis (HP:0005701)2.00515037
120Acute necrotizing encephalopathy (HP:0006965)1.98923732
121Lethargy (HP:0001254)1.98444987
122Enlarged kidneys (HP:0000105)1.97697118
123Furrowed tongue (HP:0000221)1.96348902
124Nephrolithiasis (HP:0000787)1.95294347
125Abnormality of the renal cortex (HP:0011035)1.93405791
126Hypophosphatemia (HP:0002148)1.92994955
127Chronic hepatic failure (HP:0100626)1.92667793
128Bilateral sensorineural hearing impairment (HP:0008619)1.92185847
129Abnormality of the middle phalanges of the toes (HP:0010183)1.91046145
130Metaphyseal irregularity (HP:0003025)1.90974268
131Congenital, generalized hypertrichosis (HP:0004540)1.89638302
132Vomiting (HP:0002013)1.89544611
133Renal tubular dysfunction (HP:0000124)1.88342933
134Vacuolated lymphocytes (HP:0001922)1.88000502
135Villous atrophy (HP:0011473)1.86694904
136Abnormality of small intestinal villus morphology (HP:0011472)1.86694904
137Abnormal tarsal ossification (HP:0008369)1.85555911
138Hyperammonemia (HP:0001987)1.84152721
139Adrenal hypoplasia (HP:0000835)1.84096394
140Focal seizures (HP:0007359)1.81139324
141Metabolic acidosis (HP:0001942)1.79654298
142Absent thumb (HP:0009777)1.78165847
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76999954
144Confusion (HP:0001289)1.76783852
145Right ventricular cardiomyopathy (HP:0011663)1.76164700
1463-Methylglutaconic aciduria (HP:0003535)1.74800749
147Decreased circulating renin level (HP:0003351)1.72087720
148Tubulointerstitial abnormality (HP:0001969)1.71218365
149Abnormality of vitamin metabolism (HP:0100508)1.71093710
150Insulin-resistant diabetes mellitus (HP:0000831)1.70827057
151Fatigable weakness (HP:0003473)1.70422388
152Abnormality of the neuromuscular junction (HP:0003398)1.70422388
153Abnormality of the proximal phalanges of the hand (HP:0009834)1.69150681
154Intestinal fistula (HP:0100819)1.68529260
155Abnormality of serum amino acid levels (HP:0003112)1.68500815
156Epileptiform EEG discharges (HP:0011182)1.67405955
157Esophageal atresia (HP:0002032)1.66671365
158Polyphagia (HP:0002591)1.66589172
159Septo-optic dysplasia (HP:0100842)1.65759547
160Acute encephalopathy (HP:0006846)1.65027704
161Rickets (HP:0002748)1.64522525
162Stomach cancer (HP:0012126)1.63867369
163Agitation (HP:0000713)1.63624574
164Facial shape deformation (HP:0011334)1.62910628
165Potter facies (HP:0002009)1.62910628
166Vascular calcification (HP:0004934)1.62488504
167Vaginal fistula (HP:0004320)1.62475297
168Epidermoid cyst (HP:0200040)1.62191965
169Abnormal enzyme/coenzyme activity (HP:0012379)1.57633870
170Metaphyseal cupping (HP:0003021)1.54499222
171Abnormality of alkaline phosphatase activity (HP:0004379)1.54470312
172Chondrocalcinosis (HP:0000934)1.53797280
173Hyperphosphatemia (HP:0002905)1.53236295
174Hyperkalemia (HP:0002153)1.51555203
175Abnormal pancreas size (HP:0012094)1.49993429
176Abnormality of Sharpey fibers (HP:0100685)1.46722042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.17218814
2WNK36.83137079
3OXSR16.31059101
4LATS16.22661736
5STK394.37921262
6LATS24.00448905
7ACVR1B3.31187690
8NLK2.83370712
9STK38L2.81444815
10NEK12.46414673
11PDK42.42887280
12PDK32.42887280
13PNCK2.30856242
14FGFR22.16827460
15WEE12.01589849
16MAPK151.96379392
17IRAK31.95159773
18STK31.88717640
19STK161.87884842
20NME11.82216108
21CDC71.80367633
22SGK4941.78098530
23SGK2231.78098530
24TNIK1.74332522
25PDK21.63077591
26MKNK21.62725591
27STK241.61696153
28PLK21.42049999
29BUB11.41224812
30SGK21.33079832
31BCKDK1.32240361
32MAP3K21.25308747
33SRPK11.24140547
34TGFBR11.20914077
35TSSK61.20634009
36MKNK11.14830564
37MST1R1.14059006
38BMPR1B1.05550903
39STK381.03645179
40NTRK21.00994172
41CASK1.00368594
42MAP2K20.99342152
43MARK10.98058750
44MELK0.97690436
45INSRR0.94345764
46PASK0.94316046
47SIK30.94084898
48IRAK10.93618587
49MST40.93384261
50WNK10.91476861
51MAP3K90.88586257
52TAF10.85487763
53PRKAA20.84189796
54VRK20.82443279
55EPHA20.80464145
56SGK30.76479982
57DAPK20.74790223
58TXK0.66792739
59LMTK20.66643295
60TRIM280.64258545
61MAP3K120.63612323
62ADRBK20.61572775
63DYRK1A0.60913789
64UHMK10.57916591
65IRAK20.56825543
66PIK3CG0.56788463
67MAPKAPK30.55595052
68PKN20.55235046
69PINK10.54233248
70FRK0.52595065
71PRKCH0.52449081
72AKT30.52361698
73PRKCG0.50663088
74PIM20.47597307
75CDK80.46615572
76ADRBK10.46027546
77GSK3A0.45787333
78BCR0.45114111
79CHEK20.45042017
80EPHA40.44735533
81PRKCE0.43855954
82CSNK1G10.43851228
83ARAF0.43566597
84CCNB10.41357370
85PRKD30.40815221
86MARK30.40358368
87MYLK0.40352813
88PAK40.38967061
89CAMK1G0.38714775
90AURKA0.38521146
91DYRK20.38382575
92CSNK1E0.38113562
93BRSK20.38064740
94ZAK0.36871052
95SGK10.36764704
96CSNK1G20.36668737
97GRK50.35721993
98TESK10.35485705
99SIK20.35428823
100ITK0.35300587
101ERBB30.33482931
102YES10.33482341
103GRK10.32805689
104NUAK10.30818285
105PRKD10.30737420
106NME20.30716892
107PTK2B0.30265548
108MAP2K10.30264130
109CAMK2G0.29960247
110DAPK10.29873334
111CSNK1A10.29689755
112KSR20.29594969
113MAP3K110.29340380
114PAK30.29319943
115PDPK10.28919075
116PLK30.28816316
117PRKCI0.28738854
118TLK10.28092237
119CSNK1D0.27118362
120TIE10.26276013
121CDK190.24434215
122ATR0.24346981
123PRKCZ0.24057380
124ALK0.23797871
125STK110.22689800
126TEC0.22519963
127CSNK1A1L0.22514316
128NEK20.22215631
129ATM0.22074859
130FGFR10.21838401
131ABL20.21786744
132PRKAA10.21428905
133TTK0.21039327
134PRKACA0.20145481
135PTK20.18466084
136CAMK2B0.17683267
137PLK10.16089764
138PLK40.15245286
139NTRK30.15124193
140CAMK2A0.13442357
141MINK10.13101869
142PBK0.12988113
143FER0.12858577
144PRKCA0.12323809
145CDK30.11832576
146EIF2AK30.11805798
147PRKACG0.11347979
148VRK10.10800692
149EIF2AK10.09956173
150MAP2K60.09356109
151CSNK2A10.08603516
152AURKB0.07391204
153PRKCD0.06740838

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.50782570
2Butanoate metabolism_Homo sapiens_hsa006503.90311940
3Collecting duct acid secretion_Homo sapiens_hsa049663.28342453
4Propanoate metabolism_Homo sapiens_hsa006403.25136610
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.17203768
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.94481897
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94207650
8Phototransduction_Homo sapiens_hsa047442.83084242
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.73170729
10Peroxisome_Homo sapiens_hsa041462.48606506
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.44731492
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28689786
13Glutathione metabolism_Homo sapiens_hsa004802.21202323
14Nicotine addiction_Homo sapiens_hsa050332.15367728
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14669045
16Oxidative phosphorylation_Homo sapiens_hsa001902.05937837
17beta-Alanine metabolism_Homo sapiens_hsa004102.03237529
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01277133
19Pyruvate metabolism_Homo sapiens_hsa006202.00098602
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93800312
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88754520
22Protein export_Homo sapiens_hsa030601.79983433
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77184935
24Mineral absorption_Homo sapiens_hsa049781.73204484
25Huntingtons disease_Homo sapiens_hsa050161.70419538
26Nitrogen metabolism_Homo sapiens_hsa009101.69478662
27Fatty acid degradation_Homo sapiens_hsa000711.69225386
28Vitamin digestion and absorption_Homo sapiens_hsa049771.67071066
29Tryptophan metabolism_Homo sapiens_hsa003801.56775340
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55377895
31Parkinsons disease_Homo sapiens_hsa050121.49213811
32Arginine and proline metabolism_Homo sapiens_hsa003301.48431355
33Fructose and mannose metabolism_Homo sapiens_hsa000511.46850730
34Carbon metabolism_Homo sapiens_hsa012001.46722594
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40505422
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.38337807
37Mismatch repair_Homo sapiens_hsa034301.34424081
38Homologous recombination_Homo sapiens_hsa034401.24440967
39Dorso-ventral axis formation_Homo sapiens_hsa043201.19952895
40Proteasome_Homo sapiens_hsa030501.18238236
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16810172
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15053854
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14753734
44Sulfur metabolism_Homo sapiens_hsa009201.13967586
45Pentose phosphate pathway_Homo sapiens_hsa000301.08677419
46Fatty acid metabolism_Homo sapiens_hsa012121.08177602
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06663895
48RNA degradation_Homo sapiens_hsa030181.05243894
49Type II diabetes mellitus_Homo sapiens_hsa049301.04975359
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03436758
51Morphine addiction_Homo sapiens_hsa050321.01972928
52Bile secretion_Homo sapiens_hsa049761.01332793
53Regulation of autophagy_Homo sapiens_hsa041401.01227213
54Protein digestion and absorption_Homo sapiens_hsa049740.98913585
55DNA replication_Homo sapiens_hsa030300.95447394
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.94856701
57Oocyte meiosis_Homo sapiens_hsa041140.92994467
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91282863
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89487347
60GABAergic synapse_Homo sapiens_hsa047270.89315835
61Phenylalanine metabolism_Homo sapiens_hsa003600.88513596
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88226682
63Other glycan degradation_Homo sapiens_hsa005110.87127684
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85867596
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.85562356
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85246930
67Arachidonic acid metabolism_Homo sapiens_hsa005900.84932750
68Metabolic pathways_Homo sapiens_hsa011000.84338100
69Vitamin B6 metabolism_Homo sapiens_hsa007500.83864901
70PPAR signaling pathway_Homo sapiens_hsa033200.83047990
71Synaptic vesicle cycle_Homo sapiens_hsa047210.82518746
72Histidine metabolism_Homo sapiens_hsa003400.82250692
73Glutamatergic synapse_Homo sapiens_hsa047240.80608748
74Circadian entrainment_Homo sapiens_hsa047130.79977609
75Alzheimers disease_Homo sapiens_hsa050100.79863704
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.77695615
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76018688
78Cell cycle_Homo sapiens_hsa041100.75783490
79Folate biosynthesis_Homo sapiens_hsa007900.73673355
80Ovarian steroidogenesis_Homo sapiens_hsa049130.73499527
81Circadian rhythm_Homo sapiens_hsa047100.72366389
82Vibrio cholerae infection_Homo sapiens_hsa051100.69916042
83Renin-angiotensin system_Homo sapiens_hsa046140.69318171
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.68255471
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68125690
86Fatty acid elongation_Homo sapiens_hsa000620.67507098
87N-Glycan biosynthesis_Homo sapiens_hsa005100.66960352
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66924690
89Spliceosome_Homo sapiens_hsa030400.66583416
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64137675
91Glycerolipid metabolism_Homo sapiens_hsa005610.63741564
92Pyrimidine metabolism_Homo sapiens_hsa002400.63612348
93Basal cell carcinoma_Homo sapiens_hsa052170.63494348
94Gastric acid secretion_Homo sapiens_hsa049710.62960967
95Cardiac muscle contraction_Homo sapiens_hsa042600.62736731
96Olfactory transduction_Homo sapiens_hsa047400.62657143
97Steroid biosynthesis_Homo sapiens_hsa001000.61218001
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60321518
99Hippo signaling pathway_Homo sapiens_hsa043900.59754139
100TGF-beta signaling pathway_Homo sapiens_hsa043500.59661599
101Lysine degradation_Homo sapiens_hsa003100.59553609
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57754444
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56626626
104Thyroid hormone synthesis_Homo sapiens_hsa049180.56619750
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56485662
106Biosynthesis of amino acids_Homo sapiens_hsa012300.56223747
107Ribosome_Homo sapiens_hsa030100.54858215
108Starch and sucrose metabolism_Homo sapiens_hsa005000.53029531
109RNA polymerase_Homo sapiens_hsa030200.52648277
110Serotonergic synapse_Homo sapiens_hsa047260.52506443
111RNA transport_Homo sapiens_hsa030130.52173480
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51836908
113Purine metabolism_Homo sapiens_hsa002300.51511420
114Adherens junction_Homo sapiens_hsa045200.50519099
115Rheumatoid arthritis_Homo sapiens_hsa053230.50263760
116One carbon pool by folate_Homo sapiens_hsa006700.49975946
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48955752
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46505665
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46025346
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45648542
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.45522414
122Non-homologous end-joining_Homo sapiens_hsa034500.44774325
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.44721409
124Calcium signaling pathway_Homo sapiens_hsa040200.44291279
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42666871
126Chemical carcinogenesis_Homo sapiens_hsa052040.42628873
127Arginine biosynthesis_Homo sapiens_hsa002200.42200982
128Melanogenesis_Homo sapiens_hsa049160.40756660
129Selenocompound metabolism_Homo sapiens_hsa004500.35405658
130Lysosome_Homo sapiens_hsa041420.33769811
131Hedgehog signaling pathway_Homo sapiens_hsa043400.31643233
132Taste transduction_Homo sapiens_hsa047420.31117650
133Sphingolipid metabolism_Homo sapiens_hsa006000.30603897
134Insulin secretion_Homo sapiens_hsa049110.28780472
135Fanconi anemia pathway_Homo sapiens_hsa034600.26152846
136Basal transcription factors_Homo sapiens_hsa030220.21494777
137Retinol metabolism_Homo sapiens_hsa008300.20100817
138Galactose metabolism_Homo sapiens_hsa000520.19894583
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.19209018
140Graft-versus-host disease_Homo sapiens_hsa053320.15431333
141Inositol phosphate metabolism_Homo sapiens_hsa005620.15095431
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14531916
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13051791

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