OXCT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.16132607
2spermatid nucleus differentiation (GO:0007289)8.48682367
3single strand break repair (GO:0000012)8.11888476
4microtubule depolymerization (GO:0007019)7.98281697
5spermatid development (GO:0007286)7.92580841
6response to pheromone (GO:0019236)7.92329699
7sexual reproduction (GO:0019953)7.91223883
8plasma membrane fusion (GO:0045026)7.80489591
9rRNA methylation (GO:0031167)7.63121781
10binding of sperm to zona pellucida (GO:0007339)7.63006802
11sperm-egg recognition (GO:0035036)7.60384583
12negative regulation of inclusion body assembly (GO:0090084)7.03255026
13reproduction (GO:0000003)6.53741867
14rRNA modification (GO:0000154)6.39860700
15multicellular organism reproduction (GO:0032504)6.36346382
16phosphatidylethanolamine biosynthetic process (GO:0006646)6.18185155
17cell-cell recognition (GO:0009988)6.17520557
18microtubule polymerization or depolymerization (GO:0031109)6.02111352
19calcium ion-dependent exocytosis (GO:0017156)5.84519345
20microtubule severing (GO:0051013)5.59305847
21protein polyglutamylation (GO:0018095)5.58924696
22spermatogenesis (GO:0007283)5.56027174
23phosphatidylethanolamine metabolic process (GO:0046337)5.55201532
24male gamete generation (GO:0048232)5.54168144
25chromatin silencing (GO:0006342)5.23482280
26regulation of inclusion body assembly (GO:0090083)5.10304950
27gamete generation (GO:0007276)5.03362749
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.99730323
29axonemal dynein complex assembly (GO:0070286)4.87092699
30single fertilization (GO:0007338)4.73921550
31nucleus organization (GO:0006997)4.59510537
32nucleosome disassembly (GO:0006337)4.57601212
33protein-DNA complex disassembly (GO:0032986)4.57601212
34positive regulation of Rab GTPase activity (GO:0032851)4.35171027
35regulation of Rab GTPase activity (GO:0032313)4.35171027
36germ cell development (GO:0007281)4.33387549
37motile cilium assembly (GO:0044458)4.26072335
38DNA conformation change (GO:0071103)4.21739063
39coenzyme catabolic process (GO:0009109)4.20391643
40protein targeting to Golgi (GO:0000042)4.19258697
41cellular process involved in reproduction in multicellular organism (GO:0022412)4.12050320
42multicellular organismal reproductive process (GO:0048609)4.10046441
43polyamine biosynthetic process (GO:0006596)4.09978338
44peptidyl-proline hydroxylation (GO:0019511)4.00402600
45mitotic G1 DNA damage checkpoint (GO:0031571)3.89864357
46establishment of protein localization to Golgi (GO:0072600)3.88962211
47centriole replication (GO:0007099)3.87088815
48retrograde transport, vesicle recycling within Golgi (GO:0000301)3.84043412
49centriole assembly (GO:0098534)3.79289640
50regulation of cilium movement (GO:0003352)3.78473472
51cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.73161699
52regulation of centriole replication (GO:0046599)3.70752099
53peptidyl-threonine dephosphorylation (GO:0035970)3.70600034
54membrane protein intracellular domain proteolysis (GO:0031293)3.68436918
554-hydroxyproline metabolic process (GO:0019471)3.67027862
56fertilization (GO:0009566)3.64926552
57glycerol ether metabolic process (GO:0006662)3.64634276
58cell wall macromolecule catabolic process (GO:0016998)3.63463859
59regulation of transcription involved in cell fate commitment (GO:0060850)3.63270356
60negative regulation of gene expression, epigenetic (GO:0045814)3.60799524
61homeostasis of number of cells within a tissue (GO:0048873)3.54061315
62histone H3-K9 demethylation (GO:0033169)3.51641835
63mitotic G1/S transition checkpoint (GO:0044819)3.40145940
64G1 DNA damage checkpoint (GO:0044783)3.39758132
65RNA destabilization (GO:0050779)3.35831225
66cell wall macromolecule metabolic process (GO:0044036)3.35138391
67negative regulation of histone methylation (GO:0031061)3.31501156
68nuclear pore complex assembly (GO:0051292)3.29853648
69organic cation transport (GO:0015695)3.29668564
70ether metabolic process (GO:0018904)3.29225601
71response to acidic pH (GO:0010447)3.20901537
72protein depolymerization (GO:0051261)3.19637137
73mesenchymal cell differentiation involved in kidney development (GO:0072161)3.17525367
74mesenchymal cell differentiation involved in renal system development (GO:2001012)3.17525367
75regulation of histone H3-K27 methylation (GO:0061085)3.15259070
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.14146287
77chaperone-mediated protein complex assembly (GO:0051131)3.13504331
78regulation of interleukin-13 production (GO:0032656)3.12715018
79tooth mineralization (GO:0034505)3.10463485
80cilium or flagellum-dependent cell motility (GO:0001539)3.07113410
81cellular response to pH (GO:0071467)3.04977528
82regulation of T-helper 2 cell differentiation (GO:0045628)3.01533804
83intracellular estrogen receptor signaling pathway (GO:0030520)3.01229921
84negative regulation of Rho protein signal transduction (GO:0035024)2.99510473
85protein hydroxylation (GO:0018126)2.96410993
86positive regulation of myotube differentiation (GO:0010831)2.94438228
87outflow tract septum morphogenesis (GO:0003148)2.92560258
88glomerular visceral epithelial cell development (GO:0072015)2.91637285
89multicellular organismal movement (GO:0050879)2.88795134
90musculoskeletal movement (GO:0050881)2.88795134
91protein localization to Golgi apparatus (GO:0034067)2.87993993
92regulation of ARF GTPase activity (GO:0032312)2.86140571
93mitochondrial fission (GO:0000266)2.82147454
94histone exchange (GO:0043486)2.79778374
95cerebral cortex neuron differentiation (GO:0021895)2.76516547
96acrosome reaction (GO:0007340)12.0497960
97chromosome condensation (GO:0030261)10.8936522
98sperm motility (GO:0030317)10.7505550
99fusion of sperm to egg plasma membrane (GO:0007342)10.4303721
100DNA packaging (GO:0006323)10.3010306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.95964482
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41947277
3LXR_22292898_ChIP-Seq_THP-1_Human3.33145866
4* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.99520602
5ELF1_20517297_ChIP-Seq_JURKAT_Human2.98824778
6P68_20966046_ChIP-Seq_HELA_Human2.46961151
7SMC4_20622854_ChIP-Seq_HELA_Human2.31469499
8BCOR_27268052_Chip-Seq_Bcells_Human2.26447480
9CTCF_27219007_Chip-Seq_Bcells_Human2.19302688
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12668560
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08024072
12E2F7_22180533_ChIP-Seq_HELA_Human2.07670098
13E2F1_20622854_ChIP-Seq_HELA_Human2.07618959
14* BCL6_27268052_Chip-Seq_Bcells_Human2.06842711
15PHF8_20622854_ChIP-Seq_HELA_Human2.03797839
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.03677086
17YY1_22570637_ChIP-Seq_MALME-3M_Human2.01560662
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.97018932
19SA1_27219007_Chip-Seq_ERYTHROID_Human1.95944658
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95690159
21EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.95518265
22CTCF_20526341_ChIP-Seq_ESCs_Human1.91535098
23RAC3_21632823_ChIP-Seq_H3396_Human1.84695425
24TP63_22573176_ChIP-Seq_HFKS_Human1.83843096
25ERA_21632823_ChIP-Seq_H3396_Human1.81482007
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79623799
27SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.72841201
28TET1_21451524_ChIP-Seq_MESCs_Mouse1.67164808
29SA1_27219007_Chip-Seq_Bcells_Human1.65965742
30P300_27268052_Chip-Seq_Bcells_Human1.64605491
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.63480526
32CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58458866
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58039058
34MYC_22102868_ChIP-Seq_BL_Human1.56347094
35VDR_21846776_ChIP-Seq_THP-1_Human1.56236794
36NANOG_20526341_ChIP-Seq_ESCs_Human1.55317594
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52475164
38CTCF_21964334_Chip-Seq_Bcells_Human1.47535042
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46801738
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.45036576
41RARA_24833708_ChIP-Seq_LIVER_Mouse1.42832147
42MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41957718
43OCT4_20526341_ChIP-Seq_ESCs_Human1.39055084
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35255670
45TAF2_19829295_ChIP-Seq_ESCs_Human1.34731855
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34494819
47SPI1_20517297_ChIP-Seq_HL60_Human1.32212362
48FOXP1_21924763_ChIP-Seq_HESCs_Human1.31308952
49RACK7_27058665_Chip-Seq_MCF-7_Human1.30004971
50FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29811257
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29408783
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.29108198
53FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28800569
54TCF7_22412390_ChIP-Seq_EML_Mouse1.28263170
55* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.27482098
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26556101
57KDM2B_26808549_Chip-Seq_DND41_Human1.25893684
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25567385
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25402933
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25354198
61MAF_26560356_Chip-Seq_TH2_Human1.25145377
62NCOR1_26117541_ChIP-Seq_K562_Human1.24959181
63CSB_26484114_Chip-Seq_FIBROBLAST_Human1.24799430
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22273375
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21526332
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20511564
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.18286341
68TP53_22127205_ChIP-Seq_IMR90_Human1.16752124
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15908605
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15841873
71JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13352095
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12663501
73WDR5_24793694_ChIP-Seq_LNCAP_Human1.12650669
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.11905304
75GATA1_19941826_ChIP-Seq_K562_Human1.10487031
76ETS1_21867929_ChIP-Seq_TH2_Mouse1.10258005
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.09618217
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09158555
79SOX11_22085726_ChIP-Seq_ESNs_Mouse1.09123996
80GATA3_21867929_ChIP-Seq_CD8_Mouse1.07945034
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06336579
82ATF3_27146783_Chip-Seq_COLON_Human1.05708721
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04873541
84MYC_19829295_ChIP-Seq_ESCs_Human1.03992544
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03428942
86RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02491053
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.02211796
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02065075
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02065075
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.01379433
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00321447
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.00282069
93CREB1_26743006_Chip-Seq_LNCaP_Human0.99522251
94NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98910465
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98678300
96OCT4_19829295_ChIP-Seq_ESCs_Human0.98526283
97P53_21459846_ChIP-Seq_SAOS-2_Human0.98418158
98* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98292169
99DROSHA_22980978_ChIP-Seq_HELA_Human0.97856725
100KDM2B_26808549_Chip-Seq_K562_Human0.97801702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.46820944
2MP0003698_abnormal_male_reproductive4.20574686
3MP0005377_hearing/vestibular/ear_phenot4.01558392
4MP0003878_abnormal_ear_physiology4.01558392
5MP0001348_abnormal_lacrimal_gland3.91520261
6MP0001929_abnormal_gametogenesis3.72193141
7MP0000678_abnormal_parathyroid_gland3.15432515
8MP0002132_abnormal_respiratory_system2.62003053
9MP0002161_abnormal_fertility/fecundity2.51160037
10MP0005410_abnormal_fertilization12.0586600
11MP0003718_maternal_effect1.95864934
12MP0005451_abnormal_body_composition1.89171143
13MP0004510_myositis1.73284881
14MP0002249_abnormal_larynx_morphology1.70199001
15MP0003011_delayed_dark_adaptation1.69233032
16MP0003077_abnormal_cell_cycle1.67140747
17MP0005623_abnormal_meninges_morphology1.65878758
18MP0002210_abnormal_sex_determination1.64551386
19MP0002138_abnormal_hepatobiliary_system1.56183487
20MP0009053_abnormal_anal_canal1.50651225
21MP0001145_abnormal_male_reproductive1.39807616
22MP0004957_abnormal_blastocyst_morpholog1.31314031
23MP0000534_abnormal_ureter_morphology1.26925967
24MP0003705_abnormal_hypodermis_morpholog1.22220703
25MP0005310_abnormal_salivary_gland1.21368004
26MP0000653_abnormal_sex_gland1.19193672
27MP0003091_abnormal_cell_migration1.17356000
28MP0005666_abnormal_adipose_tissue1.16391750
29MP0005379_endocrine/exocrine_gland_phen1.15195524
30MP0003111_abnormal_nucleus_morphology1.13162241
31MP0004233_abnormal_muscle_weight1.13136415
32MP0000003_abnormal_adipose_tissue1.11080200
33MP0002234_abnormal_pharynx_morphology1.10871642
34MP0000681_abnormal_thyroid_gland1.05452564
35MP0003693_abnormal_embryo_hatching1.04992471
36MP0005375_adipose_tissue_phenotype1.04982167
37MP0005395_other_phenotype1.03420930
38MP0004742_abnormal_vestibular_system0.98896910
39MP0008057_abnormal_DNA_replication0.96063575
40MP0003172_abnormal_lysosome_physiology0.90065316
41MP0001873_stomach_inflammation0.89555864
42MP0002282_abnormal_trachea_morphology0.89214970
43MP0009697_abnormal_copulation0.87178363
44MP0005083_abnormal_biliary_tract0.83239332
45MP0000313_abnormal_cell_death0.80799511
46MP0002127_abnormal_cardiovascular_syste0.80251854
47MP0001765_abnormal_ion_homeostasis0.80173523
48MP0003646_muscle_fatigue0.79482227
49MP0001666_abnormal_nutrient_absorption0.78879112
50MP0010307_abnormal_tumor_latency0.77172311
51MP0000613_abnormal_salivary_gland0.76743571
52MP0010094_abnormal_chromosome_stability0.74232133
53MP0001849_ear_inflammation0.73082248
54MP0000733_abnormal_muscle_development0.70592994
55MP0008995_early_reproductive_senescence0.67082347
56MP0003879_abnormal_hair_cell0.66906302
57MP0001730_embryonic_growth_arrest0.65696011
58MP0002080_prenatal_lethality0.64471407
59MP0000026_abnormal_inner_ear0.64370012
60MP0000685_abnormal_immune_system0.63494074
61MP0001963_abnormal_hearing_physiology0.63264195
62MP0005423_abnormal_somatic_nervous0.61038216
63MP0003699_abnormal_female_reproductive0.60683693
64MP0009115_abnormal_fat_cell0.57134175
65MP0000049_abnormal_middle_ear0.57031768
66MP0001672_abnormal_embryogenesis/_devel0.54887402
67MP0005380_embryogenesis_phenotype0.54887402
68MP0005257_abnormal_intraocular_pressure0.54507675
69MP0008438_abnormal_cutaneous_collagen0.54354904
70MP0000350_abnormal_cell_proliferation0.53211252
71MP0000566_synostosis0.53035045
72MP0003115_abnormal_respiratory_system0.52317988
73MP0009278_abnormal_bone_marrow0.51998896
74MP0000467_abnormal_esophagus_morphology0.51885696
75MP0002085_abnormal_embryonic_tissue0.51209948
76MP0004782_abnormal_surfactant_physiolog0.50580313
77MP0001270_distended_abdomen0.50354241
78MP0000470_abnormal_stomach_morphology0.49975270
79MP0003786_premature_aging0.49196004
80MP0002254_reproductive_system_inflammat0.48266945
81MP0001661_extended_life_span0.47821793
82MP0002735_abnormal_chemical_nociception0.47358536
83MP0003942_abnormal_urinary_system0.46129857
84MP0004947_skin_inflammation0.45805793
85MP0000249_abnormal_blood_vessel0.45571172
86MP0002229_neurodegeneration0.43987627
87MP0008961_abnormal_basal_metabolism0.42657996
88MP0008569_lethality_at_weaning0.42294248
89MP0003566_abnormal_cell_adhesion0.41964504
90MP0005647_abnormal_sex_gland0.41162535
91MP0005332_abnormal_amino_acid0.40763998
92MP0002269_muscular_atrophy0.40744840
93MP0003868_abnormal_feces_composition0.40236548
94MP0008874_decreased_physiological_sensi0.37789818
95MP0005645_abnormal_hypothalamus_physiol0.36735063
96MP0005076_abnormal_cell_differentiation0.36641928
97MP0001614_abnormal_blood_vessel0.35623277
98MP0008007_abnormal_cellular_replicative0.34634391
99MP0008932_abnormal_embryonic_tissue0.33934307
100MP0000703_abnormal_thymus_morphology0.33909943

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.49731508
2Resting tremor (HP:0002322)4.89285492
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.59304140
4Nasal polyposis (HP:0100582)4.34397142
5Bony spicule pigmentary retinopathy (HP:0007737)4.32712959
6Asymmetric septal hypertrophy (HP:0001670)4.28951344
7Bell-shaped thorax (HP:0001591)4.18560170
8Unilateral renal agenesis (HP:0000122)4.02406826
9Absent/shortened dynein arms (HP:0200106)3.80052860
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.80052860
11Hyperkalemia (HP:0002153)3.65030530
12Male infertility (HP:0003251)3.63625149
13Abnormality of the nasal mucosa (HP:0000433)3.63587173
14Progressive sensorineural hearing impairment (HP:0000408)3.59245842
15Attenuation of retinal blood vessels (HP:0007843)3.53351437
16Flattened epiphyses (HP:0003071)3.50375582
17Infertility (HP:0000789)3.44587617
18Aplasia/Hypoplasia of the earlobes (HP:0009906)3.35389550
19Azoospermia (HP:0000027)3.25597467
20Facial shape deformation (HP:0011334)3.21657003
21Potter facies (HP:0002009)3.21657003
22Abnormal rod and cone electroretinograms (HP:0008323)3.19144700
23Abnormal spermatogenesis (HP:0008669)3.10587882
24Hypoplastic ischia (HP:0003175)3.09021467
25Impulsivity (HP:0100710)3.05530570
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96968088
27Enlarged epiphyses (HP:0010580)2.93475504
28Tubulointerstitial nephritis (HP:0001970)2.89210165
29Progressive hearing impairment (HP:0001730)2.88920151
30Abnormality of macular pigmentation (HP:0008002)2.88168507
31Hypoplasia of the thymus (HP:0000778)2.86201414
32Hyperthyroidism (HP:0000836)2.85635987
33Cone-rod dystrophy (HP:0000548)2.76610494
34Renovascular hypertension (HP:0100817)2.72226764
35Upper limb muscle weakness (HP:0003484)2.68138498
36Abnormal respiratory motile cilium physiology (HP:0012261)2.66735552
37Insidious onset (HP:0003587)2.63475590
38Termporal pattern (HP:0011008)2.63475590
39Epiphyseal dysplasia (HP:0002656)2.63136609
40Abnormality of the ischium (HP:0003174)2.62700546
41Abnormal ciliary motility (HP:0012262)2.59700671
42Abnormality of the aortic arch (HP:0012303)2.58808361
43Double outlet right ventricle (HP:0001719)2.51647849
44Congenital malformation of the right heart (HP:0011723)2.51647849
45Absent epiphyses (HP:0010577)2.50445081
46Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.50445081
47Recurrent pneumonia (HP:0006532)2.50069270
48Sensory axonal neuropathy (HP:0003390)2.48873036
49Hypoalphalipoproteinemia (HP:0003233)2.48706156
50Atelectasis (HP:0100750)2.47328580
51Abnormal respiratory epithelium morphology (HP:0012253)2.44641413
52Abnormal respiratory motile cilium morphology (HP:0005938)2.44641413
53Ventricular tachycardia (HP:0004756)2.41067454
54Hypertensive crisis (HP:0100735)2.38097081
55Bowel incontinence (HP:0002607)2.32195012
56Truncus arteriosus (HP:0001660)2.26573671
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25977382
58Hypoparathyroidism (HP:0000829)2.25012381
59Seborrheic dermatitis (HP:0001051)2.22011995
60Abnormal ventriculo-arterial connection (HP:0011563)2.21530654
61Transposition of the great arteries (HP:0001669)2.21530654
62Abnormal connection of the cardiac segments (HP:0011545)2.21530654
63Abnormal large intestine physiology (HP:0012700)2.20631389
64Aplasia/Hypoplasia of the thymus (HP:0010515)2.17533182
65Gastrointestinal stroma tumor (HP:0100723)2.16225290
66Generalized aminoaciduria (HP:0002909)2.15423776
67Chronic hepatic failure (HP:0100626)2.11530763
68Insulin resistance (HP:0000855)2.10857196
69Renal dysplasia (HP:0000110)2.06109393
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03004731
71Acanthosis nigricans (HP:0000956)2.00189694
72Atrophic scars (HP:0001075)1.98358652
73Postural instability (HP:0002172)1.97926414
74Premature rupture of membranes (HP:0001788)1.97652296
75Peripheral hypomyelination (HP:0007182)1.96735455
76Spastic paraparesis (HP:0002313)1.96369061
77Stage 5 chronic kidney disease (HP:0003774)1.95592996
78Patellar dislocation (HP:0002999)1.95431666
79Abnormality of the parathyroid morphology (HP:0011766)1.95272181
80Insulin-resistant diabetes mellitus (HP:0000831)1.95218307
81Hypergonadotropic hypogonadism (HP:0000815)1.94825455
82Focal segmental glomerulosclerosis (HP:0000097)1.90952507
83Short nail (HP:0001799)1.88274817
84Hyponatremia (HP:0002902)1.85537150
85Recurrent lower respiratory tract infections (HP:0002783)1.83150886
86Abnormality of the epiphysis of the femoral head (HP:0010574)1.83122476
87Increased purine levels (HP:0004368)1.79899790
88Hyperuricemia (HP:0002149)1.79899790
89Bradycardia (HP:0001662)1.77469468
90Protuberant abdomen (HP:0001538)1.76840826
91Distal upper limb amyotrophy (HP:0007149)1.76571396
92Upper limb amyotrophy (HP:0009129)1.76571396
93Rhabdomyolysis (HP:0003201)1.76289780
94Hand muscle atrophy (HP:0009130)1.76186808
95Ulnar bowing (HP:0003031)1.74311085
96Glossoptosis (HP:0000162)1.74277039
97Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.74189536
98Abnormality of femoral epiphyses (HP:0006499)1.74189536
99Menstrual irregularities (HP:0000858)1.70617288
100Abnormality of DNA repair (HP:0003254)1.68931305

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.37230975
2TESK15.92783944
3DDR24.66230570
4STK383.05708117
5CDK122.72249446
6MAP4K22.40122491
7CAMK1G2.35225532
8BRD42.32119076
9MST1R2.13498053
10PRKD32.11524733
11SMG11.95694682
12EEF2K1.95417767
13KSR21.95078468
14INSRR1.88134081
15PNCK1.82584733
16PDPK11.77039787
17MAP3K91.75358603
18TRIB31.74314371
19CDK71.67115275
20MAP3K81.60071070
21NME21.51322585
22CAMK1D1.44406094
23PDK11.39189569
24STK38L1.37718702
25PLK21.35406445
26ARAF1.35019255
27WNK11.34873425
28BRAF1.34302275
29RIPK41.28153714
30ICK1.27284472
31LATS21.26702765
32MAPK151.26177148
33CDK41.16739113
34IRAK31.12445935
35SIK21.08971049
36DYRK1B1.05129580
37MAPK111.05005804
38MAP3K131.04927187
39MTOR1.01637503
40CDC70.92259405
41PIK3CG0.90333267
42PRKG20.88885934
43PRPF4B0.88760281
44MAP2K20.88706376
45MAP3K110.85338060
46CHEK10.84602046
47ZAK0.83801494
48RPS6KA20.80723225
49AURKA0.79780787
50BUB10.71014899
51CDK20.70564265
52TESK20.70325305
53BRSK10.67659348
54RPS6KA10.65461004
55MAP3K10.65044160
56CDK10.61061233
57FGFR40.57413737
58BRSK20.55435843
59MAP3K20.54254572
60GSK3B0.53092663
61PTK2B0.52601301
62VRK10.52382762
63ERN10.50450670
64NEK60.50287486
65NEK20.49085924
66CHEK20.44699950
67PAK20.44608808
68TLK10.44527017
69RPS6KL10.42714465
70RPS6KC10.42714465
71PRKAA20.41767176
72MET0.40966188
73UHMK10.40540885
74MAPK80.39293000
75ROCK10.38591100
76MAPK10.38464223
77SIK10.36600007
78MAPK140.35227212
79MAP3K100.34373626
80EPHA20.34182658
81MAPK100.32110637
82CAMK40.31560759
83RPS6KA50.30155079
84CDK30.29234328
85IKBKB0.28929850
86DAPK30.28298064
87CSF1R0.27943345
88RPS6KA60.27113143
89TTK0.26312714
90PASK0.25665141
91NEK90.25099471
92CDK90.24391393
93FLT30.24350936
94PIM20.23734442
95AURKB0.23727939
96PAK10.23640603
97PRKG10.23639159
98MAP2K10.22442845
99PRKAA10.22010870
100MARK20.21859740

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.64531448
2Olfactory transduction_Homo sapiens_hsa047403.34573168
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.79394147
4Systemic lupus erythematosus_Homo sapiens_hsa053222.61194024
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.29566878
6Phenylalanine metabolism_Homo sapiens_hsa003602.23807227
7Allograft rejection_Homo sapiens_hsa053302.23436101
8Biosynthesis of amino acids_Homo sapiens_hsa012302.16412211
9Autoimmune thyroid disease_Homo sapiens_hsa053202.15606149
10RNA transport_Homo sapiens_hsa030132.12913848
11Viral myocarditis_Homo sapiens_hsa054162.05912320
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99907190
13Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.97634902
14Antigen processing and presentation_Homo sapiens_hsa046121.95640525
15DNA replication_Homo sapiens_hsa030301.87008382
16Alcoholism_Homo sapiens_hsa050341.85485441
17Type I diabetes mellitus_Homo sapiens_hsa049401.80086917
18Graft-versus-host disease_Homo sapiens_hsa053321.79037713
19Arginine biosynthesis_Homo sapiens_hsa002201.76711696
20Arginine and proline metabolism_Homo sapiens_hsa003301.70535346
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.67118839
22Viral carcinogenesis_Homo sapiens_hsa052031.58822043
23Fatty acid metabolism_Homo sapiens_hsa012121.56669863
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54367601
25Base excision repair_Homo sapiens_hsa034101.39360250
26Sulfur relay system_Homo sapiens_hsa041221.36179370
27Influenza A_Homo sapiens_hsa051641.33399796
28Fatty acid degradation_Homo sapiens_hsa000711.30341635
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25227741
30Vitamin B6 metabolism_Homo sapiens_hsa007501.23238262
31Acute myeloid leukemia_Homo sapiens_hsa052211.18996878
32Carbon metabolism_Homo sapiens_hsa012001.18794181
33B cell receptor signaling pathway_Homo sapiens_hsa046621.18101686
34mRNA surveillance pathway_Homo sapiens_hsa030151.15287834
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.14771293
36Type II diabetes mellitus_Homo sapiens_hsa049301.12171250
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10844498
38Renin-angiotensin system_Homo sapiens_hsa046141.06301176
39Spliceosome_Homo sapiens_hsa030401.02222600
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.99758691
41Central carbon metabolism in cancer_Homo sapiens_hsa052300.98811875
42Endocytosis_Homo sapiens_hsa041440.98267560
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95265330
44Epstein-Barr virus infection_Homo sapiens_hsa051690.92360638
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89269809
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89103939
47Fanconi anemia pathway_Homo sapiens_hsa034600.85469399
48Herpes simplex infection_Homo sapiens_hsa051680.85454544
49Lysine degradation_Homo sapiens_hsa003100.84997036
50Estrogen signaling pathway_Homo sapiens_hsa049150.82045319
51Selenocompound metabolism_Homo sapiens_hsa004500.81934642
52Dorso-ventral axis formation_Homo sapiens_hsa043200.81056171
53Protein digestion and absorption_Homo sapiens_hsa049740.78766177
54Bladder cancer_Homo sapiens_hsa052190.77452479
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76355620
56Tyrosine metabolism_Homo sapiens_hsa003500.75198967
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75005037
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.73463284
59Hedgehog signaling pathway_Homo sapiens_hsa043400.70326290
60VEGF signaling pathway_Homo sapiens_hsa043700.67886898
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65313177
62Inositol phosphate metabolism_Homo sapiens_hsa005620.63055030
63Cell cycle_Homo sapiens_hsa041100.61591396
64Purine metabolism_Homo sapiens_hsa002300.61208665
65Oocyte meiosis_Homo sapiens_hsa041140.59806910
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59502336
67PPAR signaling pathway_Homo sapiens_hsa033200.57545891
68One carbon pool by folate_Homo sapiens_hsa006700.56515371
69Mismatch repair_Homo sapiens_hsa034300.54353092
70N-Glycan biosynthesis_Homo sapiens_hsa005100.53881072
71Pyrimidine metabolism_Homo sapiens_hsa002400.53866018
72Pentose phosphate pathway_Homo sapiens_hsa000300.53441869
73Fat digestion and absorption_Homo sapiens_hsa049750.52422577
74Homologous recombination_Homo sapiens_hsa034400.52122293
75Fructose and mannose metabolism_Homo sapiens_hsa000510.50731229
76Prostate cancer_Homo sapiens_hsa052150.47771035
77ECM-receptor interaction_Homo sapiens_hsa045120.47233252
78Other glycan degradation_Homo sapiens_hsa005110.46085470
79Apoptosis_Homo sapiens_hsa042100.44888515
80Non-small cell lung cancer_Homo sapiens_hsa052230.42312064
81Toxoplasmosis_Homo sapiens_hsa051450.42154693
82Prion diseases_Homo sapiens_hsa050200.40380621
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39481302
84Chronic myeloid leukemia_Homo sapiens_hsa052200.36960987
85Bile secretion_Homo sapiens_hsa049760.36827669
86HTLV-I infection_Homo sapiens_hsa051660.36665396
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35294557
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34175107
89Taste transduction_Homo sapiens_hsa047420.33911451
90Focal adhesion_Homo sapiens_hsa045100.33576304
91Notch signaling pathway_Homo sapiens_hsa043300.32456426
92Galactose metabolism_Homo sapiens_hsa000520.30878584
93Retinol metabolism_Homo sapiens_hsa008300.29486507
94MAPK signaling pathway_Homo sapiens_hsa040100.28659449
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.28016590
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27449447
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27375630
98Prolactin signaling pathway_Homo sapiens_hsa049170.26221965
99Thyroid cancer_Homo sapiens_hsa052160.25341952
100Nucleotide excision repair_Homo sapiens_hsa034200.23738632

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