OVGP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)7.84624776
2cellular response to cadmium ion (GO:0071276)6.73354843
3cellular response to follicle-stimulating hormone stimulus (GO:0071372)6.59120559
4phosphate ion homeostasis (GO:0055062)5.84390476
5trivalent inorganic anion homeostasis (GO:0072506)5.84390476
6positive regulation of inositol phosphate biosynthetic process (GO:0060732)5.67588991
7mating behavior (GO:0007617)5.39377141
8histone H3-K36 demethylation (GO:0070544)5.11982634
9cellular response to gonadotropin stimulus (GO:0071371)5.05661926
10estrogen metabolic process (GO:0008210)5.02818974
11C21-steroid hormone biosynthetic process (GO:0006700)4.97153067
12embryonic heart tube development (GO:0035050)4.87030166
13response to follicle-stimulating hormone (GO:0032354)4.79861520
14progesterone metabolic process (GO:0042448)4.74524479
15regulation of inositol phosphate biosynthetic process (GO:0010919)4.74252622
16negative regulation of inclusion body assembly (GO:0090084)4.66043062
17piRNA metabolic process (GO:0034587)4.65169807
18cellular response to epinephrine stimulus (GO:0071872)4.62579566
19androgen metabolic process (GO:0008209)4.57305953
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.54472276
21tachykinin receptor signaling pathway (GO:0007217)4.47090126
22cellular response to antibiotic (GO:0071236)4.40226368
23synaptonemal complex assembly (GO:0007130)4.15324470
24positive regulation of action potential (GO:0045760)4.13322119
25response to epinephrine (GO:0071871)4.03994477
26very-low-density lipoprotein particle assembly (GO:0034379)4.01942780
27positive regulation of receptor internalization (GO:0002092)3.99977622
28regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.99946156
29phospholipid efflux (GO:0033700)3.92713160
30male meiosis I (GO:0007141)3.87657382
31mesenchymal cell differentiation involved in kidney development (GO:0072161)3.87334696
32mesenchymal cell differentiation involved in renal system development (GO:2001012)3.87334696
33presynaptic membrane assembly (GO:0097105)3.85763663
34plasma lipoprotein particle assembly (GO:0034377)3.85028309
35cholesterol efflux (GO:0033344)3.82536224
36positive regulation of epidermal cell differentiation (GO:0045606)3.81240759
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.79992896
38peroxisome fission (GO:0016559)3.77042376
39synaptonemal complex organization (GO:0070193)3.76825971
40righting reflex (GO:0060013)3.72960916
41protein-lipid complex assembly (GO:0065005)3.69455445
42parturition (GO:0007567)3.68715558
43poly(A)+ mRNA export from nucleus (GO:0016973)3.62024699
44DNA methylation involved in gamete generation (GO:0043046)3.61100249
45coenzyme A biosynthetic process (GO:0015937)3.59863675
46seminiferous tubule development (GO:0072520)3.54636488
47protein targeting to Golgi (GO:0000042)3.54513373
48hormone biosynthetic process (GO:0042446)3.53335764
49endothelial tube morphogenesis (GO:0061154)3.53141736
50morphogenesis of an endothelium (GO:0003159)3.53141736
51response to gonadotropin (GO:0034698)3.50189669
52histone H3-K9 demethylation (GO:0033169)3.48045026
53biotin metabolic process (GO:0006768)3.47401293
54presynaptic membrane organization (GO:0097090)3.47264207
55establishment of protein localization to Golgi (GO:0072600)3.43574048
56postsynaptic membrane organization (GO:0001941)3.38462830
57regulation of protein kinase A signaling (GO:0010738)3.36106194
58histone H4 deacetylation (GO:0070933)3.35285647
59COPII vesicle coating (GO:0048208)3.33712753
60retrograde transport, vesicle recycling within Golgi (GO:0000301)3.33192064
61diacylglycerol metabolic process (GO:0046339)3.31155994
62uterus development (GO:0060065)3.30946398
63cellular response to interferon-alpha (GO:0035457)3.25886272
64cellular response to toxic substance (GO:0097237)3.24435234
65positive regulation of cAMP-mediated signaling (GO:0043950)3.24037909
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.23816120
67positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.20471310
68high-density lipoprotein particle remodeling (GO:0034375)3.19470959
69histone lysine demethylation (GO:0070076)3.17154861
70negative regulation of sterol transport (GO:0032372)3.16926827
71negative regulation of cholesterol transport (GO:0032375)3.16926827
72histone demethylation (GO:0016577)3.16614191
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15546160
74interkinetic nuclear migration (GO:0022027)3.13863144
75mRNA transcription from RNA polymerase II promoter (GO:0042789)3.12708187
76carnitine shuttle (GO:0006853)3.11210220
77histone H3 deacetylation (GO:0070932)3.10852444
78C21-steroid hormone metabolic process (GO:0008207)3.10529043
79regulation of monocyte differentiation (GO:0045655)3.09651959
80viral protein processing (GO:0019082)3.09646604
81histone H3-K4 trimethylation (GO:0080182)3.06711236
82embryonic retina morphogenesis in camera-type eye (GO:0060059)3.04651467
83chromosome organization involved in meiosis (GO:0070192)3.04275684
84mitochondrion distribution (GO:0048311)3.04004274
85meiosis I (GO:0007127)3.03653560
86regulation of receptor internalization (GO:0002090)3.03075479
87negative regulation of cAMP-mediated signaling (GO:0043951)3.00522155
88positive regulation of protein homooligomerization (GO:0032464)2.98743534
89positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.97234267
90desmosome organization (GO:0002934)2.95749555
91response to insecticide (GO:0017085)2.93051550
92import into cell (GO:0098657)2.92950184
93amino-acid betaine transport (GO:0015838)2.90655161
94carnitine transport (GO:0015879)2.90655161
95mature B cell differentiation (GO:0002335)2.88582731
96negative regulation of erythrocyte differentiation (GO:0045647)2.87640889
97glucocorticoid biosynthetic process (GO:0006704)2.85925572
98reverse cholesterol transport (GO:0043691)2.85778382
99neuron cell-cell adhesion (GO:0007158)2.82841285
100Leydig cell differentiation (GO:0033327)2.82332188
101positive regulation of digestive system process (GO:0060456)2.82209031
102opsonization (GO:0008228)2.82060144
103glucocorticoid metabolic process (GO:0008211)2.79950737
104decidualization (GO:0046697)2.78977148
105calcium-mediated signaling using intracellular calcium source (GO:0035584)2.78944678
106ionotropic glutamate receptor signaling pathway (GO:0035235)2.78253907
107protein dealkylation (GO:0008214)2.77521223
108protein demethylation (GO:0006482)2.77521223
109mRNA transcription (GO:0009299)2.76517389
110plasma lipoprotein particle clearance (GO:0034381)2.75953526
111histone H3-K9 modification (GO:0061647)2.75532540
112negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75441574
113positive regulation of skeletal muscle tissue development (GO:0048643)2.74862738
114regulation of inclusion body assembly (GO:0090083)2.72989569
115monoubiquitinated protein deubiquitination (GO:0035520)2.72483945
116regulation of ARF protein signal transduction (GO:0032012)2.71780384
117regulation of skeletal muscle cell differentiation (GO:2001014)2.69919037
118protein carboxylation (GO:0018214)2.69915202
119peptidyl-glutamic acid carboxylation (GO:0017187)2.69915202
120cellular response to catecholamine stimulus (GO:0071870)2.69689518
121cellular response to monoamine stimulus (GO:0071868)2.69689518
122female gonad development (GO:0008585)2.67607906
123positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.67068983
124negative regulation of bone resorption (GO:0045779)2.66561667
125ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.66546231
126reflex (GO:0060004)2.64537079
127cell migration involved in gastrulation (GO:0042074)2.64280399
128potassium ion export (GO:0071435)2.62095544
129histone H3-K4 methylation (GO:0051568)2.61380931
130histone H4-K12 acetylation (GO:0043983)2.60955268
131DNA synthesis involved in DNA repair (GO:0000731)2.60400280
132positive regulation of alcohol biosynthetic process (GO:1902932)2.60081269
133omega-hydroxylase P450 pathway (GO:0097267)2.59599251
134vocalization behavior (GO:0071625)2.58717122
135limb bud formation (GO:0060174)2.57805546
136regulation of action potential (GO:0098900)2.57792125
137positive regulation of renal sodium excretion (GO:0035815)2.57406782
138peptidyl-lysine dimethylation (GO:0018027)2.57153212
139response to catecholamine (GO:0071869)2.56551269
140response to monoamine (GO:0071867)2.56551269
141regulation of meiosis I (GO:0060631)2.55345954
142carnitine transmembrane transport (GO:1902603)2.55287088
143regulation of male gonad development (GO:2000018)2.55051209
144regulation of chromatin binding (GO:0035561)2.54440939
145regulation of timing of cell differentiation (GO:0048505)2.54327130
146mitochondrion localization (GO:0051646)2.53732695
147energy homeostasis (GO:0097009)2.53579400
148L-phenylalanine catabolic process (GO:0006559)2.52322410
149erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52322410
150cytokine metabolic process (GO:0042107)2.52148231
151cerebral cortex radially oriented cell migration (GO:0021799)2.51341759
152fatty acid transmembrane transport (GO:1902001)2.50742756
153glutamate receptor signaling pathway (GO:0007215)2.50720516
154negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.50332683
155protein localization to Golgi apparatus (GO:0034067)2.50105316
156behavioral response to cocaine (GO:0048148)2.50035171
157intra-Golgi vesicle-mediated transport (GO:0006891)2.49362780
158regulation of protein activation cascade (GO:2000257)2.49234034
159positive regulation of CREB transcription factor activity (GO:0032793)2.49130526
160phosphorelay signal transduction system (GO:0000160)2.48676828
161genitalia morphogenesis (GO:0035112)2.48428010
162short-term memory (GO:0007614)2.48069694
163motile cilium assembly (GO:0044458)2.47743089
164regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47240731
165central nervous system myelination (GO:0022010)2.46079016
166axon ensheathment in central nervous system (GO:0032291)2.46079016
167regulation of steroid hormone biosynthetic process (GO:0090030)2.43617131
168startle response (GO:0001964)2.43469083
169positive regulation of receptor-mediated endocytosis (GO:0048260)2.43437287
170vitamin D metabolic process (GO:0042359)2.42955753
171protein localization to synapse (GO:0035418)2.42445051
172epoxygenase P450 pathway (GO:0019373)2.40267517
173positive regulation of synapse assembly (GO:0051965)2.39993363
174retina layer formation (GO:0010842)2.38554525
175response to vitamin E (GO:0033197)2.36614054
176positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.34370785
177regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.34196954
178neuronal action potential propagation (GO:0019227)2.33123840
179mature B cell differentiation involved in immune response (GO:0002313)2.31574400
180response to corticosterone (GO:0051412)2.30425192
181regulation of synaptic transmission, GABAergic (GO:0032228)2.29458956
182positive regulation of male gonad development (GO:2000020)2.29320358
183extracellular regulation of signal transduction (GO:1900115)2.28490382
184extracellular negative regulation of signal transduction (GO:1900116)2.28490382
185cellular response to growth hormone stimulus (GO:0071378)2.28370204
186positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.27964529
187mesenchymal cell differentiation (GO:0048762)2.27611031
188neuron recognition (GO:0008038)2.27559851
189cell differentiation involved in kidney development (GO:0061005)2.27499291
190regulation of cAMP-dependent protein kinase activity (GO:2000479)2.27048350
191superoxide anion generation (GO:0042554)2.24852274
192G-protein coupled receptor internalization (GO:0002031)2.24711271
193cilium or flagellum-dependent cell motility (GO:0001539)2.24539911
194regulation of synapse assembly (GO:0051963)2.21612049
195cornea development in camera-type eye (GO:0061303)2.21224604
196multi-organism reproductive behavior (GO:0044705)2.19783616
197G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.19428968
198cranial nerve structural organization (GO:0021604)2.17657076
199estrogen biosynthetic process (GO:0006703)10.9333076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99005042
2GBX2_23144817_ChIP-Seq_PC3_Human3.93029957
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50225825
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.30685130
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.10710028
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68728740
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.57512235
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45366913
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36445230
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.36223823
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30034967
12TAF15_26573619_Chip-Seq_HEK293_Human2.27557261
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25759159
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19017663
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.18365525
16KDM2B_26808549_Chip-Seq_DND41_Human2.15907560
17CREB1_26743006_Chip-Seq_LNCaP_Human2.15492540
18TCF7_22412390_ChIP-Seq_EML_Mouse2.14513262
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12927795
20P68_20966046_ChIP-Seq_HELA_Human2.10144615
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09611803
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09598392
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.07607790
24MAF_26560356_Chip-Seq_TH2_Human2.07584736
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07479539
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.06981462
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06610689
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.03359053
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02405433
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00784185
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99850707
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99850707
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.97606514
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96241504
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.93077886
36SMC4_20622854_ChIP-Seq_HELA_Human1.91832298
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89887411
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.89843967
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87629855
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85764823
41P300_19829295_ChIP-Seq_ESCs_Human1.85385928
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85064891
43KDM2B_26808549_Chip-Seq_K562_Human1.84956781
44LXR_22292898_ChIP-Seq_THP-1_Human1.84228046
45KDM5A_27292631_Chip-Seq_BREAST_Human1.82678061
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82518081
47CIITA_25753668_ChIP-Seq_RAJI_Human1.82138669
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.79412539
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79395603
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78957772
51VDR_21846776_ChIP-Seq_THP-1_Human1.77556425
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77496959
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.77183430
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.75324366
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74576299
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.72470008
57SMAD4_21799915_ChIP-Seq_A2780_Human1.69433850
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69396824
59UTX_26944678_Chip-Seq_JUKART_Human1.67750586
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67683651
61RACK7_27058665_Chip-Seq_MCF-7_Human1.67511994
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65802489
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.65720408
64KDM2B_26808549_Chip-Seq_JURKAT_Human1.64588122
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64531300
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.64482461
67OCT4_19829295_ChIP-Seq_ESCs_Human1.63644990
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62494359
69IGF1R_20145208_ChIP-Seq_DFB_Human1.62394359
70PHF8_20622854_ChIP-Seq_HELA_Human1.62333940
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61906952
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61737743
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61330787
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60696135
75RNF2_27304074_Chip-Seq_NSC_Mouse1.60038121
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59163145
77CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59083536
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55581982
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.55458547
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.55231876
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.54279230
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.54119552
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53935694
84AR_21572438_ChIP-Seq_LNCaP_Human1.53858815
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53631699
86FUS_26573619_Chip-Seq_HEK293_Human1.53577727
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.53355693
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.53017055
89P53_22387025_ChIP-Seq_ESCs_Mouse1.51399633
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50814298
91RXR_22158963_ChIP-Seq_LIVER_Mouse1.50257470
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50217959
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50091010
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.49813735
95SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48700057
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.48497784
97ER_23166858_ChIP-Seq_MCF-7_Human1.48469866
98MYC_22102868_ChIP-Seq_BL_Human1.47794928
99CTCF_27219007_Chip-Seq_Bcells_Human1.47504408
100TET1_21451524_ChIP-Seq_MESCs_Mouse1.46335821
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46177099
102MAF_26560356_Chip-Seq_TH1_Human1.45769074
103CHD1_26751641_Chip-Seq_LNCaP_Human1.43771883
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43683002
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43678860
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41236093
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40758941
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40513365
109VDR_22108803_ChIP-Seq_LS180_Human1.40235520
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40094826
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39020349
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.38992570
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38983588
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.38936752
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.38769451
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.38471599
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.36564324
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36350392
119BCOR_27268052_Chip-Seq_Bcells_Human1.35961783
120AR_25329375_ChIP-Seq_VCAP_Human1.34674785
121* FOXA2_19822575_ChIP-Seq_HepG2_Human1.34639808
122STAT3_23295773_ChIP-Seq_U87_Human1.33586999
123IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32734756
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32573840
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32253301
126WDR5_24793694_ChIP-Seq_LNCAP_Human1.31337846
127TP53_18474530_ChIP-ChIP_U2OS_Human1.29659285
128P300_18555785_Chip-Seq_ESCs_Mouse1.28511345
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28384582
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27583660
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27177908
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26638349
133RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26553624
134OCT4_18555785_Chip-Seq_ESCs_Mouse1.26239809
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25905895
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25793813
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25582653
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25138190
139NMYC_18555785_Chip-Seq_ESCs_Mouse1.24233008
140SOX2_18555785_Chip-Seq_ESCs_Mouse1.23957010
141* E2F1_20622854_ChIP-Seq_HELA_Human1.23055815
142BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.22164174
143REST_21632747_ChIP-Seq_MESCs_Mouse1.21806666
144MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21742372
145RUNX2_22187159_ChIP-Seq_PCA_Human1.21240664
146DROSHA_22980978_ChIP-Seq_HELA_Human1.21119079
147FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20888045
148RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20324271
149TCF4_23295773_ChIP-Seq_U87_Human1.20203532
150ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19971755
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19725143
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19725143
153THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19420867
154TP53_16413492_ChIP-PET_HCT116_Human1.19013589
155CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18915472
156CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17616820
157CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17340312
158RUNX1_27514584_Chip-Seq_MCF-7_Human1.17184572
159RUNX1_22412390_ChIP-Seq_EML_Mouse1.15497815
160TFEB_21752829_ChIP-Seq_HELA_Human1.15360845
161PU1_27457419_Chip-Seq_LIVER_Mouse1.15270726
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14805912
163BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14148416
164NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13440326
165EWS_26573619_Chip-Seq_HEK293_Human1.13396146
166SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12824265
167ARNT_22903824_ChIP-Seq_MCF-7_Human1.12693634
168POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12421964
169AHR_22903824_ChIP-Seq_MCF-7_Human1.11888550
170BCL6_27268052_Chip-Seq_Bcells_Human1.11070555
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10731170
172P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10602457
173TAL1_26923725_Chip-Seq_HPCs_Mouse1.10578879
174KLF4_18555785_Chip-Seq_ESCs_Mouse1.10512590
175DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09808940
176CTCF_21964334_Chip-Seq_Bcells_Human1.09489574
177NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08779479
178ETS1_21867929_ChIP-Seq_TH2_Mouse1.08353512
179ERA_21632823_ChIP-Seq_H3396_Human1.08076912
180SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07196572
181JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05143199
182FOXA1_25552417_ChIP-Seq_VCAP_Human1.04913439
183VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03530978
184PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03454451
185EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03076768
186LXR_22158963_ChIP-Seq_LIVER_Mouse1.02582486
187XRN2_22483619_ChIP-Seq_HELA_Human1.01329762
188TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00673816
189ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99977143
190GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99463720
191PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98992403
192MYB_26560356_Chip-Seq_TH1_Human0.95930163
193KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95703987
194MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95495123
195TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95433350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004185_abnormal_adipocyte_glucose4.00917985
2MP0004233_abnormal_muscle_weight3.88864194
3MP0009840_abnormal_foam_cell3.55399882
4MP0005647_abnormal_sex_gland3.18809091
5MP0003315_abnormal_perineum_morphology3.16579477
6MP0006292_abnormal_olfactory_placode2.89932169
7MP0002822_catalepsy2.88400612
8MP0003787_abnormal_imprinting2.83959006
9MP0005666_abnormal_adipose_tissue2.77125042
10MP0008995_early_reproductive_senescence2.74640690
11MP0001188_hyperpigmentation2.72060170
12MP0003880_abnormal_central_pattern2.62628545
13MP0002102_abnormal_ear_morphology2.59718912
14MP0005377_hearing/vestibular/ear_phenot2.57572169
15MP0003878_abnormal_ear_physiology2.57572169
16MP0003136_yellow_coat_color2.56996785
17MP0005451_abnormal_body_composition2.56137148
18MP0001919_abnormal_reproductive_system2.52775683
19MP0002928_abnormal_bile_duct2.45330155
20MP0004859_abnormal_synaptic_plasticity2.40566776
21MP0003879_abnormal_hair_cell2.38808167
22MP0002876_abnormal_thyroid_physiology2.37270298
23MP0005084_abnormal_gallbladder_morpholo2.33661600
24MP0003195_calcinosis2.33060075
25MP0005409_darkened_coat_color2.31646675
26MP0003123_paternal_imprinting2.21190715
27MP0005645_abnormal_hypothalamus_physiol2.20028752
28MP0010386_abnormal_urinary_bladder2.13912113
29MP0001486_abnormal_startle_reflex2.09710607
30MP0004130_abnormal_muscle_cell2.08280164
31MP0003172_abnormal_lysosome_physiology2.05550762
32MP0003943_abnormal_hepatobiliary_system2.03897857
33MP0002638_abnormal_pupillary_reflex1.97741316
34MP0009745_abnormal_behavioral_response1.95320251
35MP0000566_synostosis1.89943223
36MP0005670_abnormal_white_adipose1.89509310
37MP0001440_abnormal_grooming_behavior1.80535050
38MP0001986_abnormal_taste_sensitivity1.80015280
39MP0005171_absent_coat_pigmentation1.77576473
40MP0005375_adipose_tissue_phenotype1.77103866
41MP0001346_abnormal_lacrimal_gland1.75416356
42MP0005646_abnormal_pituitary_gland1.74207943
43MP0009046_muscle_twitch1.70354642
44MP0005551_abnormal_eye_electrophysiolog1.70075531
45MP0003635_abnormal_synaptic_transmissio1.70002499
46MP0005187_abnormal_penis_morphology1.69025809
47MP0002557_abnormal_social/conspecific_i1.67384481
48MP0004742_abnormal_vestibular_system1.67155501
49MP0002736_abnormal_nociception_after1.63678670
50MP0002139_abnormal_hepatobiliary_system1.63550656
51MP0005389_reproductive_system_phenotype1.62818336
52MP0008260_abnormal_autophagy1.62622994
53MP0001968_abnormal_touch/_nociception1.61608003
54MP0002572_abnormal_emotion/affect_behav1.60246715
55MP0002132_abnormal_respiratory_system1.60007050
56MP0005379_endocrine/exocrine_gland_phen1.58198093
57MP0002272_abnormal_nervous_system1.58016287
58MP0002735_abnormal_chemical_nociception1.51954609
59MP0002064_seizures1.51703770
60MP0000631_abnormal_neuroendocrine_gland1.50998408
61MP0001501_abnormal_sleep_pattern1.49542721
62MP0002067_abnormal_sensory_capabilities1.47707684
63MP0000639_abnormal_adrenal_gland1.47045312
64MP0005253_abnormal_eye_physiology1.46493592
65MP0002277_abnormal_respiratory_mucosa1.45640272
66MP0003763_abnormal_thymus_physiology1.44098436
67MP0002063_abnormal_learning/memory/cond1.43491184
68MP0002734_abnormal_mechanical_nocicepti1.40880056
69MP0001963_abnormal_hearing_physiology1.39937973
70MP0002160_abnormal_reproductive_system1.39803364
71MP0000516_abnormal_urinary_system1.36886153
72MP0005367_renal/urinary_system_phenotyp1.36886153
73MP0000026_abnormal_inner_ear1.36872655
74MP0006072_abnormal_retinal_apoptosis1.34246380
75MP0008961_abnormal_basal_metabolism1.34183530
76MP0000049_abnormal_middle_ear1.28511794
77MP0009250_abnormal_appendicular_skeleto1.27658549
78MP0006276_abnormal_autonomic_nervous1.27164677
79MP0005257_abnormal_intraocular_pressure1.25442839
80MP0003183_abnormal_peptide_metabolism1.24677050
81MP0005248_abnormal_Harderian_gland1.23070574
82MP0005448_abnormal_energy_balance1.22458310
83MP0005360_urolithiasis1.22028907
84MP0002184_abnormal_innervation1.21845069
85MP0000778_abnormal_nervous_system1.21561385
86MP0001984_abnormal_olfaction1.20679531
87MP0001502_abnormal_circadian_rhythm1.20375337
88MP0002254_reproductive_system_inflammat1.19784726
89MP0002163_abnormal_gland_morphology1.19348447
90MP0004145_abnormal_muscle_electrophysio1.16216817
91MP0005058_abnormal_lysosome_morphology1.15319669
92MP0005423_abnormal_somatic_nervous1.13995111
93MP0008875_abnormal_xenobiotic_pharmacok1.11350542
94MP0008877_abnormal_DNA_methylation1.11175112
95MP0010234_abnormal_vibrissa_follicle1.10303213
96MP0001944_abnormal_pancreas_morphology1.08863312
97MP0002210_abnormal_sex_determination1.07353007
98MP0010329_abnormal_lipoprotein_level1.07147277
99MP0001905_abnormal_dopamine_level1.06704674
100MP0000015_abnormal_ear_pigmentation1.06678436
101MP0002971_abnormal_brown_adipose1.05420277
102MP0003938_abnormal_ear_development1.04544868
103MP0001970_abnormal_pain_threshold1.04406833
104MP0002751_abnormal_autonomic_nervous1.04260932
105MP0002909_abnormal_adrenal_gland1.02225851
106MP0001929_abnormal_gametogenesis1.02137286
107MP0003698_abnormal_male_reproductive1.00246664
108MP0001145_abnormal_male_reproductive0.99424102
109MP0001661_extended_life_span0.95650691
110MP0002752_abnormal_somatic_nervous0.93151892
111MP0003122_maternal_imprinting0.92562990
112MP0000920_abnormal_myelination0.91782458
113MP0001727_abnormal_embryo_implantation0.91154898
114MP0004142_abnormal_muscle_tone0.91093632
115MP0003121_genomic_imprinting0.90162727
116MP0005334_abnormal_fat_pad0.90105544
117MP0000681_abnormal_thyroid_gland0.90032402
118MP0002118_abnormal_lipid_homeostasis0.89917640
119MP0009115_abnormal_fat_cell0.89433971
120MP0010368_abnormal_lymphatic_system0.89260855
121MP0004133_heterotaxia0.87843336
122MP0002249_abnormal_larynx_morphology0.86300636
123MP0002078_abnormal_glucose_homeostasis0.84951157
124MP0002970_abnormal_white_adipose0.83438608
125MP0004270_analgesia0.82319901
126MP0001666_abnormal_nutrient_absorption0.82197226
127MP0002932_abnormal_joint_morphology0.81924445
128MP0001873_stomach_inflammation0.81419770
129MP0000653_abnormal_sex_gland0.81405748
130MP0002882_abnormal_neuron_morphology0.80926606
131MP0001485_abnormal_pinna_reflex0.80154427
132MP0009672_abnormal_birth_weight0.80010364
133MP0000003_abnormal_adipose_tissue0.78779037
134MP0000537_abnormal_urethra_morphology0.77465852
135MP0003953_abnormal_hormone_level0.76980196
136MP0004147_increased_porphyrin_level0.76968351
137MP0003937_abnormal_limbs/digits/tail_de0.75162325
138MP0000462_abnormal_digestive_system0.74442953
139MP0002148_abnormal_hypersensitivity_rea0.74017684
140MP0002138_abnormal_hepatobiliary_system0.73478959
141MP0005174_abnormal_tail_pigmentation0.73231702
142MP0005220_abnormal_exocrine_pancreas0.71633654
143MP0001851_eye_inflammation0.71380254
144MP0005595_abnormal_vascular_smooth0.70963066
145MP0003950_abnormal_plasma_membrane0.69918475
146MP0003690_abnormal_glial_cell0.68865142
147MP0009333_abnormal_splenocyte_physiolog0.68695166
148MP0004019_abnormal_vitamin_homeostasis0.67333241
149MP0001765_abnormal_ion_homeostasis0.66759865
150MP0000609_abnormal_liver_physiology0.66234902
151MP0005584_abnormal_enzyme/coenzyme_acti0.65714180
152MP0002177_abnormal_outer_ear0.65516924
153MP0005195_abnormal_posterior_eye0.65333745
154MP0001529_abnormal_vocalization0.65265805
155MP0004885_abnormal_endolymph0.63809437
156MP0004381_abnormal_hair_follicle0.63418662
157MP0002066_abnormal_motor_capabilities/c0.62542188
158MP0002161_abnormal_fertility/fecundity0.60474909
159MP0003699_abnormal_female_reproductive0.60439678
160MP0005386_behavior/neurological_phenoty0.60202025
161MP0004924_abnormal_behavior0.60202025
162MP0002229_neurodegeneration0.59937881
163MP0003868_abnormal_feces_composition0.59619515
164MP0005310_abnormal_salivary_gland0.59267094
165MP0008569_lethality_at_weaning0.58903348
166MP0004134_abnormal_chest_morphology0.58881464
167MP0003828_pulmonary_edema0.58406969

Predicted human phenotypes

RankGene SetZ-score
1Abnormal sex determination (HP:0012244)5.28035854
2Sex reversal (HP:0012245)5.28035854
3Gonadotropin excess (HP:0000837)4.90235858
4Hypobetalipoproteinemia (HP:0003563)4.41814416
5Asymmetry of the thorax (HP:0001555)4.14721265
6Prolonged partial thromboplastin time (HP:0003645)3.88257634
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86996719
8Hyperlipoproteinemia (HP:0010980)3.85676947
9Tubulointerstitial nephritis (HP:0001970)3.76335664
10Enlarged penis (HP:0000040)3.67584377
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.57955827
12Absent/shortened dynein arms (HP:0200106)3.57955827
13Febrile seizures (HP:0002373)3.53214869
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.50345829
15Focal motor seizures (HP:0011153)3.46651607
16Deep venous thrombosis (HP:0002625)3.42624987
17Septo-optic dysplasia (HP:0100842)3.40849616
18Chromsome breakage (HP:0040012)3.34853529
19Renal salt wasting (HP:0000127)3.32488421
20Macroorchidism (HP:0000053)3.32026857
21Spontaneous abortion (HP:0005268)3.30741022
22Hyperinsulinemic hypoglycemia (HP:0000825)3.29697649
23Fibular hypoplasia (HP:0003038)3.09298137
24Sensory axonal neuropathy (HP:0003390)3.06784269
25Abnormal ciliary motility (HP:0012262)3.00977261
26Osteomalacia (HP:0002749)2.99797601
27Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.94759938
28Abnormality of carpal bone ossification (HP:0006257)2.94525012
29Hyperaldosteronism (HP:0000859)2.84716886
30Fibular aplasia (HP:0002990)2.81967023
31Hypoglycemic seizures (HP:0002173)2.81080629
32Supranuclear gaze palsy (HP:0000605)2.79781588
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.79190033
34Abnormal hand bone ossification (HP:0010660)2.76865717
35Abnormal tarsal ossification (HP:0008369)2.73817927
36Oligodactyly (hands) (HP:0001180)2.73474702
37Aplasia cutis congenita (HP:0001057)2.69542539
38Thin bony cortex (HP:0002753)2.68195704
39Hyperpituitarism (HP:0010514)2.68124456
40Joint hemorrhage (HP:0005261)2.67676113
41Ankle clonus (HP:0011448)2.66883482
42Anomalous pulmonary venous return (HP:0010772)2.66771945
43Abnormal respiratory motile cilium physiology (HP:0012261)2.63979333
44Dysmetric saccades (HP:0000641)2.62544368
45Advanced eruption of teeth (HP:0006288)2.61464608
46Muscle fiber atrophy (HP:0100295)2.60147016
47Abnormality of the renal medulla (HP:0100957)2.59553783
48Hypercholesterolemia (HP:0003124)2.54453080
49Delayed epiphyseal ossification (HP:0002663)2.53545864
50True hermaphroditism (HP:0010459)2.53387293
51Type 2 muscle fiber atrophy (HP:0003554)2.49178126
52Absent speech (HP:0001344)2.46973280
53Abnormality of incisor morphology (HP:0011063)2.43585672
54Abnormal respiratory epithelium morphology (HP:0012253)2.43469226
55Abnormal respiratory motile cilium morphology (HP:0005938)2.43469226
56Infertility (HP:0000789)2.41924239
57Congenital stationary night blindness (HP:0007642)2.40093194
58Epileptic encephalopathy (HP:0200134)2.39760155
59Easy fatigability (HP:0003388)2.37658761
60Menstrual irregularities (HP:0000858)2.36192161
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35593231
62Abnormality of the renal collecting system (HP:0004742)2.34219997
63Abnormality of the pulmonary veins (HP:0011718)2.33746288
64Bifid scrotum (HP:0000048)2.33262466
65Abnormality of the nasal septum (HP:0000419)2.33073148
66Decreased central vision (HP:0007663)2.32308326
67Hyperventilation (HP:0002883)2.32087499
68Congenital malformation of the right heart (HP:0011723)2.31115605
69Double outlet right ventricle (HP:0001719)2.31115605
70Hypergonadotropic hypogonadism (HP:0000815)2.30820813
71Malnutrition (HP:0004395)2.30497470
72Anteriorly placed anus (HP:0001545)2.27809818
73Brittle hair (HP:0002299)2.27644070
74Retinal atrophy (HP:0001105)2.27334997
75Abnormality of the lower motor neuron (HP:0002366)2.26601857
76Bronchomalacia (HP:0002780)2.24440921
77Split foot (HP:0001839)2.24385072
78Aplasia/Hypoplasia of the fibula (HP:0006492)2.24250089
79Abnormal ossification of hand bones (HP:0005921)2.24065205
80Prostate neoplasm (HP:0100787)2.22960123
81Absent septum pellucidum (HP:0001331)2.22864114
82Hand muscle atrophy (HP:0009130)2.22057305
83Optic nerve hypoplasia (HP:0000609)2.21153554
84Nephronophthisis (HP:0000090)2.19414350
85Abnormal foot bone ossification (HP:0010675)2.18757015
86Duplicated collecting system (HP:0000081)2.17506115
87Hyperkalemia (HP:0002153)2.17440220
88Amyotrophic lateral sclerosis (HP:0007354)2.17164995
89Hypoglycemic coma (HP:0001325)2.17025667
90Poor suck (HP:0002033)2.15951423
91Craniofacial hyperostosis (HP:0004493)2.15875133
92Impaired vibratory sensation (HP:0002495)2.15556659
93Renal cortical cysts (HP:0000803)2.15331394
94Abnormality of the corticospinal tract (HP:0002492)2.14423010
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13559136
96Azoospermia (HP:0000027)2.12940931
97Bulbar palsy (HP:0001283)2.12672818
98Enlarged epiphyses (HP:0010580)2.10631047
99Deep palmar crease (HP:0006191)2.08211044
100Progressive cerebellar ataxia (HP:0002073)2.07857563
101Thyroid-stimulating hormone excess (HP:0002925)2.07840792
102Natal tooth (HP:0000695)2.06619883
103Truncal ataxia (HP:0002078)2.06470465
104Nonprogressive disorder (HP:0003680)2.05645293
105Occipital encephalocele (HP:0002085)2.02904817
106Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01907438
107Lip pit (HP:0100267)2.00591075
108Xanthomatosis (HP:0000991)2.00140226
109Ectopic kidney (HP:0000086)1.99503216
110Abnormality of endocrine pancreas physiology (HP:0012093)1.98329934
111Abnormality of the pancreatic islet cells (HP:0006476)1.98329934
112White forelock (HP:0002211)1.97924143
113Male pseudohermaphroditism (HP:0000037)1.97609875
114Atonic seizures (HP:0010819)1.97304915
115Absent frontal sinuses (HP:0002688)1.96414895
11611 pairs of ribs (HP:0000878)1.95604102
117Nasal speech (HP:0001611)1.95044753
118Patchy hypopigmentation of hair (HP:0011365)1.94636108
119Hypophosphatemic rickets (HP:0004912)1.92968957
120Short tibia (HP:0005736)1.92844059
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.92825262
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92825262
123Abnormality of chloride homeostasis (HP:0011422)1.91619292
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.91584957
125Abnormality of the septum pellucidum (HP:0007375)1.91227894
126Sporadic (HP:0003745)1.91039160
127Growth hormone excess (HP:0000845)1.90956475
128Cranial hyperostosis (HP:0004437)1.90903505
129Anal stenosis (HP:0002025)1.90858752
130Absent eyebrow (HP:0002223)1.90150456
131Widely patent fontanelles and sutures (HP:0004492)1.87941895
132Hypothermia (HP:0002045)1.87649876
133Rhabdomyolysis (HP:0003201)1.87000732
134Submucous cleft hard palate (HP:0000176)1.86726682
135Neonatal hypoglycemia (HP:0001998)1.86198922
136Depression (HP:0000716)1.85633391
137Protruding tongue (HP:0010808)1.85589423
138Hypolipoproteinemia (HP:0010981)1.85553569
139Aplasia involving bones of the upper limbs (HP:0009823)1.85168726
140Aplasia of the phalanges of the hand (HP:0009802)1.85168726
141Aplasia involving bones of the extremities (HP:0009825)1.85168726
142Hypercortisolism (HP:0001578)1.84684506
143Congenital sensorineural hearing impairment (HP:0008527)1.84219214
144Thoracic kyphosis (HP:0002942)1.84128729
145Abnormality of the columella (HP:0009929)1.82650790
146Neuronal loss in central nervous system (HP:0002529)1.81823834
147Heterotopia (HP:0002282)1.81643462
148Nephroblastoma (Wilms tumor) (HP:0002667)1.80844994
149Chronic hepatic failure (HP:0100626)1.80792036
150Long nose (HP:0003189)1.78317798
151Pancreatic fibrosis (HP:0100732)1.77720378
152Clubbing of toes (HP:0100760)1.77243557
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75763640
154Abnormality of the preputium (HP:0100587)1.75706976
155Median cleft lip (HP:0000161)1.75117671
156Abnormality of the Achilles tendon (HP:0005109)1.75104199
157Abnormality of midbrain morphology (HP:0002418)1.74871958
158Molar tooth sign on MRI (HP:0002419)1.74871958
159Abnormality of the fibula (HP:0002991)1.73785843
160Abnormality of the musculature of the hand (HP:0001421)1.73256679
161Impaired social interactions (HP:0000735)1.72793475
162Abnormal social behavior (HP:0012433)1.72793475
163Recurrent sinusitis (HP:0011108)1.72468125
164Conical tooth (HP:0000698)1.71903309
165Poor coordination (HP:0002370)1.71818382
166Congenital hepatic fibrosis (HP:0002612)1.71192759
167Complement deficiency (HP:0004431)1.70566280
168Short nail (HP:0001799)1.70514580
169EEG with generalized epileptiform discharges (HP:0011198)1.70435904
170Distal upper limb amyotrophy (HP:0007149)1.70386996
171Upper limb amyotrophy (HP:0009129)1.70386996
172Embryonal renal neoplasm (HP:0011794)1.70035769
173Myokymia (HP:0002411)1.69618042
174Epileptiform EEG discharges (HP:0011182)1.69362899
175Seborrheic dermatitis (HP:0001051)1.68440557
176Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67911647
177Elevated alkaline phosphatase (HP:0003155)1.67806246
178Broad distal phalanx of finger (HP:0009836)1.67503672
179Short middle phalanx of the 5th finger (HP:0004220)1.66351461
180Aplasia/Hypoplasia of the uvula (HP:0010293)1.65684133
181Fair hair (HP:0002286)1.63892864
182Broad-based gait (HP:0002136)1.63833332
183Atelectasis (HP:0100750)1.62956734
184Gastroesophageal reflux (HP:0002020)1.62573141
185Overfolded helix (HP:0000396)1.62508753
186Attenuation of retinal blood vessels (HP:0007843)1.62373148
187Abnormality of DNA repair (HP:0003254)1.61778689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.35321645
2TNIK3.79286543
3MKNK23.60083561
4CDK123.10637786
5MAP4K12.61574410
6MAP2K72.55390976
7NTRK32.45997479
8MARK22.40333722
9TAOK12.34937056
10NUAK12.26790653
11MKNK12.26325909
12INSRR2.25161929
13MAP3K142.10757275
14EEF2K1.93796096
15MAP3K131.83203629
16MUSK1.82349109
17NEK61.81279419
18SIK31.72954001
19TSSK61.72487559
20TRIB31.71352906
21PRKD31.69766287
22GRK71.58666070
23PRPF4B1.54973564
24BMPR21.54494765
25IRAK41.53640893
26BLK1.51657672
27AKT31.50298753
28PDK11.46733311
29STK161.43723864
30ICK1.43157813
31SRPK11.41575163
32MAPK131.40366882
33RIPK41.39971414
34SIK21.39477058
35EIF2AK21.37533259
36PDK21.35370822
37SIK11.34392771
38ZAK1.31230550
39CDK31.26418701
40CAMKK11.24676239
41ADRBK21.23940730
42TNK21.23115285
43TXK1.21745832
44YES11.21673579
45MAP3K101.17591321
46IRAK31.15839000
47CAMK1G1.15369057
48PKN11.11795686
49EPHA41.09398420
50DMPK1.06872228
51GRK11.06694184
52STK381.05959176
53RAF11.02643256
54SMG11.00608520
55TYRO30.98015622
56STK110.97196776
57TESK20.95801385
58NLK0.95131592
59PNCK0.93824169
60PRKCE0.93677249
61MAP3K70.91986250
62OXSR10.91292905
63RET0.91129168
64IRAK20.89969508
65PDPK10.88161133
66TESK10.88107815
67SGK20.88045341
68MAP3K90.86529392
69MARK30.86035070
70ZAP700.84975929
71BCR0.84180234
72FES0.84055387
73PRKAA10.81406976
74ERBB30.81406284
75BRD40.81101908
76DYRK1A0.80260767
77FGFR20.80229675
78NTRK20.78920288
79STK390.76546193
80TEC0.75212198
81SGK2230.74957624
82SGK4940.74957624
83SGK30.74928794
84GRK60.73464916
85PIK3CA0.73036824
86PRKG10.72678540
87BMPR1B0.72624540
88PRKCI0.71915541
89CAMK2B0.70939104
90TIE10.69546875
91MTOR0.69047920
92CAMK2A0.68521004
93FGFR40.68327702
94PLK20.67727024
95PRKCH0.67403451
96TAOK30.66733504
97MARK10.66317399
98FGR0.66251690
99FGFR30.65228983
100CDC42BPA0.65050655
101SGK10.64729188
102CDK80.64515003
103ARAF0.62312263
104CAMK1D0.62126553
105TAF10.61584494
106MAPK120.60966140
107PRKCZ0.60677818
108PRKAA20.59381785
109KSR20.58591424
110TBK10.55165618
111PRKCQ0.54001517
112MAP3K40.53355900
113MAPK110.52765586
114MAP2K60.52329118
115PRKD20.52121964
116PKN20.51405215
117NME10.49426239
118CAMK2D0.47984362
119PRKCG0.47493052
120CLK10.47327931
121CAMK10.46928179
122GRK50.46834614
123STK40.46232467
124IRAK10.45474973
125MYLK0.45021121
126MAPK70.43644506
127PRKD10.43417055
128PAK30.42711052
129PIM20.41970077
130WNK10.41200453
131MAPK80.40897987
132CAMK40.40472061
133MAPK150.40422552
134CSNK1A1L0.39921056
135OBSCN0.39587416
136FER0.39531864
137UHMK10.38919888
138PRKACA0.38145953
139RIPK10.37980864
140MAP3K60.37852217
141BMX0.37674071
142PASK0.37085909
143PRKACB0.36804937
144DYRK1B0.36780380
145CSNK1E0.36309304
146AKT20.35384350
147GSK3A0.35221113
148LYN0.34501307
149CHUK0.34445655
150PTK60.33720405
151STK240.33544290
152MAP3K20.33044616
153MAPK100.32565859
154LCK0.32242586
155GSK3B0.32234534
156PRKCA0.31661520
157CSNK1G10.31326205
158PRKCB0.31303292
159TAOK20.31192919
160RPS6KB20.30318223
161RPS6KB10.28719160
162PRKG20.28529564
163MINK10.27651603
164IKBKE0.26599497
165MAP2K30.26568672

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.37434934
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.94595294
3Nicotine addiction_Homo sapiens_hsa050333.33862953
4Phenylalanine metabolism_Homo sapiens_hsa003602.89102687
5Steroid hormone biosynthesis_Homo sapiens_hsa001402.65152552
6Phototransduction_Homo sapiens_hsa047442.38257491
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.32887773
8Morphine addiction_Homo sapiens_hsa050322.09352591
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09246092
10Other glycan degradation_Homo sapiens_hsa005112.07681126
11Taste transduction_Homo sapiens_hsa047421.96537767
12Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94270711
13Lysine degradation_Homo sapiens_hsa003101.90729859
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88771455
15Fatty acid metabolism_Homo sapiens_hsa012121.83881580
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82879384
17Glutamatergic synapse_Homo sapiens_hsa047241.75263690
18Calcium signaling pathway_Homo sapiens_hsa040201.69002469
19GABAergic synapse_Homo sapiens_hsa047271.68509086
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.65372711
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55192112
22Serotonergic synapse_Homo sapiens_hsa047261.53297309
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53270119
24Fatty acid degradation_Homo sapiens_hsa000711.50248198
25Circadian entrainment_Homo sapiens_hsa047131.42999357
26Butanoate metabolism_Homo sapiens_hsa006501.40773153
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40625651
28VEGF signaling pathway_Homo sapiens_hsa043701.39994830
29Salivary secretion_Homo sapiens_hsa049701.39464770
30Olfactory transduction_Homo sapiens_hsa047401.37117826
31Sphingolipid metabolism_Homo sapiens_hsa006001.35248305
32Complement and coagulation cascades_Homo sapiens_hsa046101.34997017
33Inositol phosphate metabolism_Homo sapiens_hsa005621.34284223
34Autoimmune thyroid disease_Homo sapiens_hsa053201.33913698
35Wnt signaling pathway_Homo sapiens_hsa043101.29258194
36Glucagon signaling pathway_Homo sapiens_hsa049221.27953027
37Regulation of autophagy_Homo sapiens_hsa041401.27640530
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27108354
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23736856
40Rheumatoid arthritis_Homo sapiens_hsa053231.22040038
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21891722
42mTOR signaling pathway_Homo sapiens_hsa041501.18517864
43Steroid biosynthesis_Homo sapiens_hsa001001.18105249
44Collecting duct acid secretion_Homo sapiens_hsa049661.17624618
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16140630
46Estrogen signaling pathway_Homo sapiens_hsa049151.14887557
47PPAR signaling pathway_Homo sapiens_hsa033201.14691335
48cAMP signaling pathway_Homo sapiens_hsa040241.14496695
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13627667
50Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11913243
51Prion diseases_Homo sapiens_hsa050201.11429229
52Fanconi anemia pathway_Homo sapiens_hsa034601.11301508
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.10043679
54Allograft rejection_Homo sapiens_hsa053301.09904273
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09430786
56Graft-versus-host disease_Homo sapiens_hsa053321.07440672
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07418564
58Non-small cell lung cancer_Homo sapiens_hsa052231.05817475
59Bile secretion_Homo sapiens_hsa049761.05721877
60ErbB signaling pathway_Homo sapiens_hsa040121.05274587
61Axon guidance_Homo sapiens_hsa043601.04747156
62Sulfur relay system_Homo sapiens_hsa041221.04632759
63Vitamin digestion and absorption_Homo sapiens_hsa049771.02965666
64Renin secretion_Homo sapiens_hsa049241.02440984
65Insulin signaling pathway_Homo sapiens_hsa049101.01732980
66Long-term depression_Homo sapiens_hsa047301.01546490
67Insulin secretion_Homo sapiens_hsa049111.00968798
68Endometrial cancer_Homo sapiens_hsa052130.99578986
69Type I diabetes mellitus_Homo sapiens_hsa049400.97935048
70Ether lipid metabolism_Homo sapiens_hsa005650.97211241
71Acute myeloid leukemia_Homo sapiens_hsa052210.95778589
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94522604
73Cholinergic synapse_Homo sapiens_hsa047250.94014659
74Oxytocin signaling pathway_Homo sapiens_hsa049210.93790900
75Tryptophan metabolism_Homo sapiens_hsa003800.93357869
76African trypanosomiasis_Homo sapiens_hsa051430.92598063
77Cocaine addiction_Homo sapiens_hsa050300.92494340
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92431328
79Arachidonic acid metabolism_Homo sapiens_hsa005900.92367555
80AMPK signaling pathway_Homo sapiens_hsa041520.92086167
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.91511427
82T cell receptor signaling pathway_Homo sapiens_hsa046600.91382780
83Prostate cancer_Homo sapiens_hsa052150.91089530
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87847017
85Thyroid hormone synthesis_Homo sapiens_hsa049180.87215950
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86941558
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.86875181
88ABC transporters_Homo sapiens_hsa020100.86558504
89Amphetamine addiction_Homo sapiens_hsa050310.85185639
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84433162
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83820370
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81759433
93Asthma_Homo sapiens_hsa053100.80642304
94Tyrosine metabolism_Homo sapiens_hsa003500.80184838
95Non-homologous end-joining_Homo sapiens_hsa034500.80127373
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80076838
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.80006625
98Gastric acid secretion_Homo sapiens_hsa049710.79274196
99Notch signaling pathway_Homo sapiens_hsa043300.79265758
100B cell receptor signaling pathway_Homo sapiens_hsa046620.76688014
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76607916
102Thyroid cancer_Homo sapiens_hsa052160.76336759
103Dopaminergic synapse_Homo sapiens_hsa047280.76193391
104Chemical carcinogenesis_Homo sapiens_hsa052040.74592687
105Insulin resistance_Homo sapiens_hsa049310.73870167
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72936678
107Circadian rhythm_Homo sapiens_hsa047100.71814187
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71575611
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69774002
110Melanoma_Homo sapiens_hsa052180.69688030
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.67921238
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67334794
113Ras signaling pathway_Homo sapiens_hsa040140.66904060
114Mineral absorption_Homo sapiens_hsa049780.66374948
115Long-term potentiation_Homo sapiens_hsa047200.66082917
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65956188
117FoxO signaling pathway_Homo sapiens_hsa040680.65135834
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64723564
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.63954720
120Staphylococcus aureus infection_Homo sapiens_hsa051500.63901235
121Peroxisome_Homo sapiens_hsa041460.63826391
122Caffeine metabolism_Homo sapiens_hsa002320.63448213
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63359977
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61481854
125Prolactin signaling pathway_Homo sapiens_hsa049170.61230821
126Chemokine signaling pathway_Homo sapiens_hsa040620.60617268
127Synaptic vesicle cycle_Homo sapiens_hsa047210.59977770
128Malaria_Homo sapiens_hsa051440.59519563
129Hematopoietic cell lineage_Homo sapiens_hsa046400.58436920
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57334411
131Melanogenesis_Homo sapiens_hsa049160.56834852
132Dilated cardiomyopathy_Homo sapiens_hsa054140.56677195
133MAPK signaling pathway_Homo sapiens_hsa040100.56388678
134mRNA surveillance pathway_Homo sapiens_hsa030150.56130879
135Type II diabetes mellitus_Homo sapiens_hsa049300.56003839
136Phagosome_Homo sapiens_hsa041450.55878498
137Fatty acid biosynthesis_Homo sapiens_hsa000610.55476954
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54886841
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54324827
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.53733595
141Vitamin B6 metabolism_Homo sapiens_hsa007500.53072069
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51882318
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51866474
144Retinol metabolism_Homo sapiens_hsa008300.50553170
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50527282
146Linoleic acid metabolism_Homo sapiens_hsa005910.50357541
147Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50243720
148Renal cell carcinoma_Homo sapiens_hsa052110.50108958
149Pancreatic secretion_Homo sapiens_hsa049720.48915260
150beta-Alanine metabolism_Homo sapiens_hsa004100.48386741
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47614683
152SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46925669
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46885206
154Primary bile acid biosynthesis_Homo sapiens_hsa001200.46406879
155Propanoate metabolism_Homo sapiens_hsa006400.45593655
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45141797
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44448550
158Osteoclast differentiation_Homo sapiens_hsa043800.43655180
159Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42516192
160Jak-STAT signaling pathway_Homo sapiens_hsa046300.42514198
161Choline metabolism in cancer_Homo sapiens_hsa052310.42287895
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40599726
163Fatty acid elongation_Homo sapiens_hsa000620.40507376
164Basal cell carcinoma_Homo sapiens_hsa052170.39491598
165TNF signaling pathway_Homo sapiens_hsa046680.37900561
166Measles_Homo sapiens_hsa051620.37451678
167GnRH signaling pathway_Homo sapiens_hsa049120.36422925
168Rap1 signaling pathway_Homo sapiens_hsa040150.36270884

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