OVCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1serotonin receptor signaling pathway (GO:0007210)9.20928540
2negative regulation of interleukin-8 production (GO:0032717)8.98513420
3positive regulation of hair follicle development (GO:0051798)8.40563089
4positive regulation of hair cycle (GO:0042635)8.40563089
5positive regulation of osteoblast proliferation (GO:0033690)8.35112499
6angiogenesis involved in wound healing (GO:0060055)7.95523864
7regulation of appetite (GO:0032098)7.31332792
8negative regulation of circadian rhythm (GO:0042754)7.31274332
9interferon-gamma production (GO:0032609)7.08676171
10regulation of Cdc42 GTPase activity (GO:0043088)6.99739316
11negative regulation of calcium ion transport into cytosol (GO:0010523)6.76788475
12activated T cell proliferation (GO:0050798)6.73673346
13hematopoietic stem cell proliferation (GO:0071425)6.68479056
14glycoprotein catabolic process (GO:0006516)6.46327172
15protein K48-linked deubiquitination (GO:0071108)6.43485043
16protein K63-linked deubiquitination (GO:0070536)6.08571083
17lymphangiogenesis (GO:0001946)5.95683460
18regulation of hair follicle development (GO:0051797)5.49677073
19carnitine transmembrane transport (GO:1902603)5.46868167
20granulocyte differentiation (GO:0030851)5.32390660
21sulfation (GO:0051923)5.24802354
22killing of cells of other organism (GO:0031640)5.22946525
23disruption of cells of other organism (GO:0044364)5.22946525
24glycerophospholipid catabolic process (GO:0046475)5.09767141
25thyroid hormone metabolic process (GO:0042403)5.03517170
26cysteine metabolic process (GO:0006534)5.01152603
27omega-hydroxylase P450 pathway (GO:0097267)5.01048288
28amino-acid betaine transport (GO:0015838)4.99997100
29carnitine transport (GO:0015879)4.99997100
30lipid translocation (GO:0034204)4.96924569
31phospholipid translocation (GO:0045332)4.96924569
32mucosal immune response (GO:0002385)4.94773077
33paraxial mesoderm development (GO:0048339)4.76870497
34organ or tissue specific immune response (GO:0002251)4.61328344
35organic cation transport (GO:0015695)4.60637409
36filopodium assembly (GO:0046847)4.54445306
37regulation of B cell receptor signaling pathway (GO:0050855)4.49063729
38carnitine metabolic process (GO:0009437)4.32980203
39negative regulation of metanephros development (GO:0072217)4.29022843
40defense response to fungus (GO:0050832)4.19555737
41homocysteine metabolic process (GO:0050667)4.11466610
42negative regulation of hormone biosynthetic process (GO:0032353)3.97861358
43quaternary ammonium group transport (GO:0015697)3.96283121
44heparan sulfate proteoglycan metabolic process (GO:0030201)3.93820620
45regulation of hair cycle (GO:0042634)3.92589919
46protein sumoylation (GO:0016925)3.88116492
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87871927
48androgen biosynthetic process (GO:0006702)3.86728055
49cilium or flagellum-dependent cell motility (GO:0001539)3.84223018
50regulation of female gonad development (GO:2000194)3.78840351
51positive regulation of cAMP-mediated signaling (GO:0043950)3.75337795
52regulation of steroid hormone biosynthetic process (GO:0090030)3.72912427
53positive regulation of epidermis development (GO:0045684)3.72525208
54flavonoid metabolic process (GO:0009812)3.72110105
55regulation of osteoblast proliferation (GO:0033688)3.71763267
56righting reflex (GO:0060013)3.69062479
57establishment of protein localization to Golgi (GO:0072600)3.60086519
58rRNA catabolic process (GO:0016075)3.59802507
59startle response (GO:0001964)3.58300324
60negative regulation of hormone metabolic process (GO:0032351)3.57913953
61positive regulation of vasculogenesis (GO:2001214)3.56811298
62negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.53781668
63dosage compensation (GO:0007549)3.48573909
64regulation of sarcomere organization (GO:0060297)3.48206871
65spindle assembly involved in mitosis (GO:0090307)3.45797842
66tryptophan catabolic process (GO:0006569)3.44076671
67indole-containing compound catabolic process (GO:0042436)3.44076671
68indolalkylamine catabolic process (GO:0046218)3.44076671
69DNA double-strand break processing (GO:0000729)3.43319379
70negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.43291151
71sex differentiation (GO:0007548)3.41538430
72purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.39243553
733-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.39243553
74cell killing (GO:0001906)3.39231592
75negative regulation by host of viral transcription (GO:0043922)3.37691257
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.35834020
77axon ensheathment in central nervous system (GO:0032291)3.35779402
78central nervous system myelination (GO:0022010)3.35779402
79regulation of membrane lipid distribution (GO:0097035)3.34403678
80meiotic cell cycle (GO:0051321)3.34199522
81maturation of 5.8S rRNA (GO:0000460)3.33888945
82phosphatidylinositol acyl-chain remodeling (GO:0036149)3.32931522
83negative regulation of mast cell activation (GO:0033004)3.32266431
84reflex (GO:0060004)3.29702398
85endothelial cell proliferation (GO:0001935)3.25651235
86triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.24765622
87amino-acid betaine metabolic process (GO:0006577)3.24578840
88skin development (GO:0043588)3.22208791
89detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16963424
90positive regulation of blood coagulation (GO:0030194)3.16616444
91positive regulation of hemostasis (GO:1900048)3.16616444
92regulation of acrosome reaction (GO:0060046)3.09074756
93low-density lipoprotein particle remodeling (GO:0034374)3.08630643
94nuclear pore organization (GO:0006999)3.07843166
95sex determination (GO:0007530)3.05789036
96retinal cone cell development (GO:0046549)3.03443401
97positive regulation of coagulation (GO:0050820)2.99516295
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.98084238
99positive regulation vascular endothelial growth factor production (GO:0010575)2.96015529
100protein K11-linked deubiquitination (GO:0035871)15.7812778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human6.53228685
2IKZF1_21737484_ChIP-ChIP_HCT116_Human4.77446900
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.17872566
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.99658684
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.54856352
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.37375053
7EZH2_22144423_ChIP-Seq_EOC_Human3.30574225
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.92509490
9DROSHA_22980978_ChIP-Seq_HELA_Human2.73366367
10AR_21572438_ChIP-Seq_LNCaP_Human2.40656226
11TP53_16413492_ChIP-PET_HCT116_Human2.35542286
12ER_23166858_ChIP-Seq_MCF-7_Human2.09532497
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05865740
14IGF1R_20145208_ChIP-Seq_DFB_Human1.96491840
15* AR_25329375_ChIP-Seq_VCAP_Human1.89242134
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86030675
17SMAD4_21799915_ChIP-Seq_A2780_Human1.76733078
18UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.75557929
19LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72065514
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71812969
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.70649227
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69801229
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.64603320
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62931533
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61887850
26FLI1_21867929_ChIP-Seq_TH2_Mouse1.60018418
27STAT3_23295773_ChIP-Seq_U87_Human1.59838774
28OCT4_21477851_ChIP-Seq_ESCs_Mouse1.58467825
29CBP_20019798_ChIP-Seq_JUKART_Human1.50628226
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50628226
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47059003
32TP53_18474530_ChIP-ChIP_U2OS_Human1.41892968
33EZH2_27294783_Chip-Seq_NPCs_Mouse1.41538869
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40654584
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39950569
36KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.39619986
37EWS_26573619_Chip-Seq_HEK293_Human1.39572569
38TP53_22573176_ChIP-Seq_HFKS_Human1.38129097
39CRX_20693478_ChIP-Seq_RETINA_Mouse1.37450125
40* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.37085661
41* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36474348
42FUS_26573619_Chip-Seq_HEK293_Human1.36323955
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.35208286
44ZNF274_21170338_ChIP-Seq_K562_Hela1.35157957
45P300_19829295_ChIP-Seq_ESCs_Human1.34951073
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34608728
47LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33777256
48* SMAD4_21741376_ChIP-Seq_EPCs_Human1.32081023
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31665323
50TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.30610746
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.30495373
52RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28879491
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27426935
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.27414034
55* TCF4_23295773_ChIP-Seq_U87_Human1.27111102
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25428383
57RUNX2_22187159_ChIP-Seq_PCA_Human1.25288867
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24986126
59CDX2_22108803_ChIP-Seq_LS180_Human1.23107153
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19431940
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19334600
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13651437
63SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13547261
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11665907
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09411213
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.09064379
67* TAF15_26573619_Chip-Seq_HEK293_Human1.06808888
68TBL1_22424771_ChIP-Seq_293T_Human1.06339933
69PHF8_20622853_ChIP-Seq_HELA_Human1.06049934
70SOX3_22085726_ChIP-Seq_MUSCLE_Mouse1.05093389
71CJUN_26792858_Chip-Seq_BT549_Human1.03833712
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03570203
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01258348
74GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00258748
75TCF4_22108803_ChIP-Seq_LS180_Human0.99077246
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98008149
77ERG_20517297_ChIP-Seq_VCAP_Human0.97487180
78VDR_22108803_ChIP-Seq_LS180_Human0.96540006
79BRD4_25478319_ChIP-Seq_HGPS_Human0.96465615
80PRDM14_20953172_ChIP-Seq_ESCs_Human0.96001954
81VDR_24787735_ChIP-Seq_THP-1_Human0.95950716
82* SMAD3_21741376_ChIP-Seq_EPCs_Human0.94567252
83BCAT_22108803_ChIP-Seq_LS180_Human0.93929424
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93366662
85ESET_19884257_ChIP-Seq_ESCs_Mouse0.92494471
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92233130
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91672639
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.89980177
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89980177
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89817418
91REST_21632747_ChIP-Seq_MESCs_Mouse0.89619398
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89585694
93* AR_19668381_ChIP-Seq_PC3_Human0.88838451
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88054682
95OCT1_27270436_Chip-Seq_PROSTATE_Human0.87254425
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86958998
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84897048
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84527223
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83697341
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83025392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism8.28732544
2MP0002138_abnormal_hepatobiliary_system5.67664101
3MP0005310_abnormal_salivary_gland4.87813027
4MP0005670_abnormal_white_adipose4.81442610
5MP0002139_abnormal_hepatobiliary_system4.28860507
6MP0008875_abnormal_xenobiotic_pharmacok4.01162079
7MP0003806_abnormal_nucleotide_metabolis3.69425123
8MP0001984_abnormal_olfaction3.32289879
9MP0002254_reproductive_system_inflammat3.27446040
10MP0004043_abnormal_pH_regulation2.53082748
11MP0001919_abnormal_reproductive_system2.38673645
12MP0001879_abnormal_lymphatic_vessel2.10656748
13MP0005389_reproductive_system_phenotype2.10207264
14MP0005647_abnormal_sex_gland1.98098889
15MP0001873_stomach_inflammation1.97506021
16MP0001348_abnormal_lacrimal_gland1.88879937
17MP0000613_abnormal_salivary_gland1.86885763
18MP0003724_increased_susceptibility_to1.85647784
19MP0006082_CNS_inflammation1.85362831
20MP0005551_abnormal_eye_electrophysiolog1.74287980
21MP0002006_tumorigenesis1.68375835
22MP0002970_abnormal_white_adipose1.55766042
23MP0006276_abnormal_autonomic_nervous1.55385259
24MP0003718_maternal_effect1.53186627
25MP0005187_abnormal_penis_morphology1.50653862
26MP0002928_abnormal_bile_duct1.50548544
27MP0000230_abnormal_systemic_arterial1.50220871
28MP0003878_abnormal_ear_physiology1.47474316
29MP0005377_hearing/vestibular/ear_phenot1.47474316
30MP0000569_abnormal_digit_pigmentation1.40225005
31MP0005084_abnormal_gallbladder_morpholo1.38152658
32MP0005410_abnormal_fertilization1.35293698
33MP0002064_seizures1.32410919
34MP0002876_abnormal_thyroid_physiology1.32164825
35MP0009046_muscle_twitch1.28558250
36MP0002735_abnormal_chemical_nociception1.26055849
37MP0005360_urolithiasis1.24182375
38MP0009745_abnormal_behavioral_response1.16030346
39MP0003638_abnormal_response/metabolism_1.12181557
40MP0002234_abnormal_pharynx_morphology1.09413857
41MP0001486_abnormal_startle_reflex1.07735341
42MP0003646_muscle_fatigue1.05934647
43MP0004142_abnormal_muscle_tone1.04039277
44MP0002127_abnormal_cardiovascular_syste1.03427409
45MP0003315_abnormal_perineum_morphology1.01190122
46MP0001764_abnormal_homeostasis1.01088391
47MP0001905_abnormal_dopamine_level0.99727582
48MP0002269_muscular_atrophy0.96688220
49MP0004858_abnormal_nervous_system0.91886013
50MP0005464_abnormal_platelet_physiology0.90989890
51MP0002971_abnormal_brown_adipose0.89602916
52MP0001986_abnormal_taste_sensitivity0.87757104
53MP0008569_lethality_at_weaning0.87509144
54MP0002160_abnormal_reproductive_system0.86697192
55MP0005595_abnormal_vascular_smooth0.83837867
56MP0003936_abnormal_reproductive_system0.82384407
57MP0005167_abnormal_blood-brain_barrier0.81467124
58MP0000383_abnormal_hair_follicle0.81212982
59MP0009278_abnormal_bone_marrow0.80166202
60MP0010329_abnormal_lipoprotein_level0.78111016
61MP0002572_abnormal_emotion/affect_behav0.77832626
62MP0001970_abnormal_pain_threshold0.75918254
63MP0002210_abnormal_sex_determination0.75200096
64MP0008961_abnormal_basal_metabolism0.74383682
65MP0000685_abnormal_immune_system0.73547614
66MP0002736_abnormal_nociception_after0.72166828
67MP0001968_abnormal_touch/_nociception0.71675423
68MP0001664_abnormal_digestion0.71223019
69MP0003252_abnormal_bile_duct0.71193961
70MP0003698_abnormal_male_reproductive0.70568344
71MP0005452_abnormal_adipose_tissue0.70132955
72MP0000639_abnormal_adrenal_gland0.69561140
73MP0008874_decreased_physiological_sensi0.68617709
74MP0005174_abnormal_tail_pigmentation0.68359712
75MP0001501_abnormal_sleep_pattern0.65381925
76MP0001346_abnormal_lacrimal_gland0.64918095
77MP0005164_abnormal_response_to0.63098468
78MP0001929_abnormal_gametogenesis0.63043015
79MP0003195_calcinosis0.61327898
80MP0000653_abnormal_sex_gland0.60625357
81MP0010678_abnormal_skin_adnexa0.60611532
82MP0008877_abnormal_DNA_methylation0.58341258
83MP0002272_abnormal_nervous_system0.57777474
84MP0010386_abnormal_urinary_bladder0.57436688
85MP0006054_spinal_hemorrhage0.56548085
86MP0003279_aneurysm0.56081760
87MP0000631_abnormal_neuroendocrine_gland0.56070831
88MP0010155_abnormal_intestine_physiology0.55355379
89MP0003632_abnormal_nervous_system0.54427953
90MP0000371_diluted_coat_color0.54025194
91MP0003045_fibrosis0.53636844
92MP0009643_abnormal_urine_homeostasis0.53411543
93MP0002419_abnormal_innate_immunity0.52986835
94MP0005387_immune_system_phenotype0.52750763
95MP0001790_abnormal_immune_system0.52750763
96MP0005666_abnormal_adipose_tissue0.52532874
97MP0001663_abnormal_digestive_system0.51827346
98MP0005253_abnormal_eye_physiology0.50860535
99MP0002452_abnormal_antigen_presenting0.50217378
100MP0002396_abnormal_hematopoietic_system0.49926079

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)6.68469717
2Retrobulbar optic neuritis (HP:0100654)6.32256050
3Optic neuritis (HP:0100653)6.32256050
4Lower limb hyperreflexia (HP:0002395)6.05085876
5Orchitis (HP:0100796)5.64723128
6Bilateral sensorineural hearing impairment (HP:0008619)5.61213558
7Keratoconjunctivitis (HP:0001096)5.36378713
8Poikiloderma (HP:0001029)5.06357772
9Myositis (HP:0100614)4.67565922
10Decreased circulating renin level (HP:0003351)4.55345934
11Keratoconjunctivitis sicca (HP:0001097)4.13941475
12Attenuation of retinal blood vessels (HP:0007843)4.11142243
13Abnormality of the pericardium (HP:0001697)4.03168096
14Abnormal pancreas size (HP:0012094)4.01265081
15Enlarged penis (HP:0000040)3.85859356
16Hypoplasia of the uterus (HP:0000013)3.83565008
17Abolished electroretinogram (ERG) (HP:0000550)3.75885017
18Congenital stationary night blindness (HP:0007642)3.59984249
19Bony spicule pigmentary retinopathy (HP:0007737)3.48696652
20Unilateral renal agenesis (HP:0000122)3.34644864
21True hermaphroditism (HP:0010459)3.26980789
22Gonadotropin excess (HP:0000837)3.05985486
23Gout (HP:0001997)3.03048965
24Tinnitus (HP:0000360)3.01103180
25Hyperglycinuria (HP:0003108)2.92402302
26Abnormality of dentin (HP:0010299)2.88592741
27Chronic hepatic failure (HP:0100626)2.74957774
28Hyperventilation (HP:0002883)2.74175048
29Bicornuate uterus (HP:0000813)2.73722948
30Male pseudohermaphroditism (HP:0000037)2.69791628
31Mesangial abnormality (HP:0001966)2.67879477
32Basal ganglia calcification (HP:0002135)2.66196604
33Anorexia (HP:0002039)2.65774002
34Abnormality of dental color (HP:0011073)2.62438184
35Xanthomatosis (HP:0000991)2.61443504
36Pancreatic cysts (HP:0001737)2.59427474
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.59399168
38Late onset (HP:0003584)2.59353273
39Aplasia/hypoplasia of the uterus (HP:0008684)2.54224908
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.52899656
41Abnormality of the left ventricular outflow tract (HP:0011103)2.48804029
42Subaortic stenosis (HP:0001682)2.48804029
43Polydipsia (HP:0001959)2.48486785
44Abnormal drinking behavior (HP:0030082)2.48486785
45Acne (HP:0001061)2.45666321
46Hemoptysis (HP:0002105)2.43781370
47Encephalitis (HP:0002383)2.43144339
48Spastic tetraparesis (HP:0001285)2.39514200
49Amelogenesis imperfecta (HP:0000705)2.39227939
50Absent speech (HP:0001344)2.37656466
51Spastic paraplegia (HP:0001258)2.36880393
52Vertigo (HP:0002321)2.36371363
53Keratitis (HP:0000491)2.35785237
54Arterial thrombosis (HP:0004420)2.34387335
55Craniofacial hyperostosis (HP:0004493)2.33720335
56Preaxial foot polydactyly (HP:0001841)2.33469656
57Hyperkalemia (HP:0002153)2.30052203
58Bicuspid aortic valve (HP:0001647)2.28119325
59Pulmonary embolism (HP:0002204)2.26130453
60Anomalous pulmonary venous return (HP:0010772)2.24661245
61Pancreatic fibrosis (HP:0100732)2.23634223
62Hyperaldosteronism (HP:0000859)2.22907781
63Breast carcinoma (HP:0003002)2.20861794
64Loss of speech (HP:0002371)2.18704938
65Glomerulopathy (HP:0100820)2.18541908
66Atrioventricular block (HP:0001678)2.14950348
67Germ cell neoplasia (HP:0100728)2.14567245
68Frequent falls (HP:0002359)2.07272433
69Paraplegia (HP:0010550)2.05358081
70Gangrene (HP:0100758)2.03919272
71Clumsiness (HP:0002312)2.03653173
72Abnormal biliary tract physiology (HP:0012439)2.02228517
73Bile duct proliferation (HP:0001408)2.02228517
74Abnormality of renin-angiotensin system (HP:0000847)2.01272867
75Cranial hyperostosis (HP:0004437)2.01147083
76Stage 5 chronic kidney disease (HP:0003774)2.00538162
77Glucose intolerance (HP:0000833)2.00173702
78Tapered finger (HP:0001182)1.98993852
79Ileus (HP:0002595)1.97548894
80Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96985762
81Abnormality of the pulmonary veins (HP:0011718)1.96729144
82Hyperactive renin-angiotensin system (HP:0000841)1.96588890
83Delayed puberty (HP:0000823)1.96381797
84Absent/shortened dynein arms (HP:0200106)1.95895317
85Dynein arm defect of respiratory motile cilia (HP:0012255)1.95895317
86Pulmonary infiltrates (HP:0002113)1.93067287
87Retinal atrophy (HP:0001105)1.91021073
88Metaphyseal dysplasia (HP:0100255)1.88868193
89Opisthotonus (HP:0002179)1.88292471
90Infertility (HP:0000789)1.88197448
91Constricted visual fields (HP:0001133)1.86123668
92Abnormal glucose tolerance (HP:0001952)1.85282581
93Abnormality of glycine metabolism (HP:0010895)1.82475828
94Abnormality of serine family amino acid metabolism (HP:0010894)1.82475828
95Delayed closure of the anterior fontanelle (HP:0001476)1.79174087
96Abnormality of the dental pulp (HP:0006479)1.78882877
97Hand muscle atrophy (HP:0009130)1.76041114
98Heart block (HP:0012722)1.74745906
99Hypoplastic ischia (HP:0003175)1.73039170
100Hydroxyprolinuria (HP:0003080)1.72336764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.32939237
2WNK36.91010992
3TXK5.15957360
4PINK14.04170359
5BLK3.25453154
6EEF2K2.90840449
7CDK122.34462686
8YES12.26254684
9MAPKAPK32.16986003
10ZAK1.80033408
11IRAK11.77277927
12FER1.71222935
13MAPKAPK51.58860224
14TRPM71.40217999
15ADRBK21.38565672
16TAOK31.38488474
17MAP4K21.36792659
18EIF2AK31.33508562
19PRKCZ1.26023754
20OXSR11.06852948
21STK391.06554577
22CSK1.06440447
23NTRK31.05581043
24GRK10.92297531
25CSF1R0.88558311
26PLK40.86409806
27EIF2AK20.86361847
28PRKD30.84263627
29MAPK130.81986183
30FLT30.77176738
31GRK70.76435826
32BMPR1B0.71301256
33PIK3CA0.64480940
34PRKD20.64403317
35TIE10.64047807
36MAPK110.64047611
37RPS6KB20.63384616
38STK38L0.62842950
39KIT0.62050605
40CHEK20.59162974
41ADRBK10.58390573
42MAP3K70.57939607
43TEC0.57871456
44PRKG10.57793467
45PIK3CG0.56452420
46IGF1R0.55742093
47MKNK10.53284312
48PDK10.51494759
49ACVR1B0.49094216
50PRKCH0.48538550
51INSRR0.45942748
52RPS6KA20.45139662
53DAPK20.44579045
54PRKCB0.41462346
55WNK40.40989418
56BMPR20.38701558
57PRKCA0.37815911
58MAP2K10.35807531
59STK240.33627916
60CAMK1D0.33248575
61BCKDK0.32410932
62MAPK100.32043841
63MAP4K10.30362736
64JAK10.30236025
65GSK3A0.29987294
66RPS6KA60.29316103
67NEK10.28683832
68STK380.28619172
69MOS0.28519837
70LYN0.28500124
71TGFBR20.28414705
72BTK0.27889418
73CAMK10.27599258
74PRKG20.26026597
75MATK0.25541535
76IKBKB0.24777532
77TGFBR10.24131883
78RPS6KA50.23296234
79NEK20.23111642
80RPS6KC10.22411076
81RPS6KL10.22411076
82STK30.22397082
83TLK10.22031404
84CAMK2A0.21951614
85PRKACA0.21625173
86MARK30.21617928
87SYK0.21453529
88RPS6KA30.20276522
89NEK60.20187695
90ITK0.19435628
91MAPK70.18945491
92GSK3B0.18860945
93MAPK10.18704124
94RPS6KB10.17955573
95TNIK0.17274391
96CDK60.17149981
97BRD40.16937548
98PRKAA20.16801890
99PDPK10.16564620
100MAP3K80.16345361

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005316.63850921
2Selenocompound metabolism_Homo sapiens_hsa004503.86667968
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20470631
4Linoleic acid metabolism_Homo sapiens_hsa005912.70195264
5Arachidonic acid metabolism_Homo sapiens_hsa005902.48524019
6Butanoate metabolism_Homo sapiens_hsa006502.39718290
7Ether lipid metabolism_Homo sapiens_hsa005652.34378775
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26160038
9Histidine metabolism_Homo sapiens_hsa003402.15760612
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13470352
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00468882
12Salivary secretion_Homo sapiens_hsa049701.95650669
13Propanoate metabolism_Homo sapiens_hsa006401.93041295
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.87458901
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.84891022
16Serotonergic synapse_Homo sapiens_hsa047261.75647016
17Dorso-ventral axis formation_Homo sapiens_hsa043201.75522517
18Nicotine addiction_Homo sapiens_hsa050331.72005413
19Staphylococcus aureus infection_Homo sapiens_hsa051501.70794285
20Glycerolipid metabolism_Homo sapiens_hsa005611.70419264
21Calcium signaling pathway_Homo sapiens_hsa040201.69873466
22Ovarian steroidogenesis_Homo sapiens_hsa049131.67920641
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66977864
24Olfactory transduction_Homo sapiens_hsa047401.64885374
25N-Glycan biosynthesis_Homo sapiens_hsa005101.58169021
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.42739370
27Phototransduction_Homo sapiens_hsa047441.40529451
28Fat digestion and absorption_Homo sapiens_hsa049751.37277723
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32693726
30Tryptophan metabolism_Homo sapiens_hsa003801.30354447
31Fatty acid biosynthesis_Homo sapiens_hsa000611.29276567
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23224429
33cAMP signaling pathway_Homo sapiens_hsa040241.21069030
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15960184
35ABC transporters_Homo sapiens_hsa020101.13377276
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.12822076
37Glutathione metabolism_Homo sapiens_hsa004801.09462049
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.09325906
39Vitamin digestion and absorption_Homo sapiens_hsa049771.03858978
40Oxytocin signaling pathway_Homo sapiens_hsa049211.02531731
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97442436
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97413969
43Fatty acid metabolism_Homo sapiens_hsa012120.94683677
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.94245499
45Lysine degradation_Homo sapiens_hsa003100.93627244
46Morphine addiction_Homo sapiens_hsa050320.93287781
47B cell receptor signaling pathway_Homo sapiens_hsa046620.91422606
48Fatty acid degradation_Homo sapiens_hsa000710.87138735
49Cholinergic synapse_Homo sapiens_hsa047250.83048150
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.77987329
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71314645
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.71186547
53Proteasome_Homo sapiens_hsa030500.69759598
54Fanconi anemia pathway_Homo sapiens_hsa034600.69470695
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66214030
56Platelet activation_Homo sapiens_hsa046110.65865742
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62255242
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59770597
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59524617
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.57774472
61Base excision repair_Homo sapiens_hsa034100.57737762
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57633270
63Peroxisome_Homo sapiens_hsa041460.57172069
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55608055
65Gastric acid secretion_Homo sapiens_hsa049710.54962267
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52996326
67RNA transport_Homo sapiens_hsa030130.52436477
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51760505
69Nitrogen metabolism_Homo sapiens_hsa009100.50766393
70Pancreatic secretion_Homo sapiens_hsa049720.48634181
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42081848
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41691347
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41612458
74Homologous recombination_Homo sapiens_hsa034400.41526762
75Metabolic pathways_Homo sapiens_hsa011000.39087650
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37861321
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32838234
78Taste transduction_Homo sapiens_hsa047420.32705194
79Chemical carcinogenesis_Homo sapiens_hsa052040.30395148
80Protein digestion and absorption_Homo sapiens_hsa049740.29489969
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29389518
82Long-term depression_Homo sapiens_hsa047300.26561703
83Primary immunodeficiency_Homo sapiens_hsa053400.25358019
84GABAergic synapse_Homo sapiens_hsa047270.23983674
85Retinol metabolism_Homo sapiens_hsa008300.19214864
86Ras signaling pathway_Homo sapiens_hsa040140.18884987
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17711983
88African trypanosomiasis_Homo sapiens_hsa051430.16861897
89PPAR signaling pathway_Homo sapiens_hsa033200.16579510
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16469522
91Adherens junction_Homo sapiens_hsa045200.16310221
92Hematopoietic cell lineage_Homo sapiens_hsa046400.16186404
93Choline metabolism in cancer_Homo sapiens_hsa052310.16117114
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.15432781
95Epstein-Barr virus infection_Homo sapiens_hsa051690.14407970
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.14163648
97Non-homologous end-joining_Homo sapiens_hsa034500.13475333
98p53 signaling pathway_Homo sapiens_hsa041150.11715459
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11453723
100TNF signaling pathway_Homo sapiens_hsa046680.10311965

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