OVCA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.59453685
2ribosomal small subunit assembly (GO:0000028)5.63585401
3translational termination (GO:0006415)5.32686651
4viral transcription (GO:0019083)5.27484857
5maturation of SSU-rRNA (GO:0030490)5.19723421
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.18761586
7ribosomal large subunit biogenesis (GO:0042273)5.09382261
8cotranslational protein targeting to membrane (GO:0006613)5.06638002
9protein targeting to ER (GO:0045047)5.06252252
10telomere maintenance via semi-conservative replication (GO:0032201)4.85136833
11negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.83347713
12proteasome assembly (GO:0043248)4.81891133
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.81382574
14protein localization to endoplasmic reticulum (GO:0070972)4.79784076
15translational elongation (GO:0006414)4.66215436
16peptidyl-histidine modification (GO:0018202)4.63562002
17DNA strand elongation involved in DNA replication (GO:0006271)4.62431324
18DNA replication initiation (GO:0006270)4.48288899
19DNA replication checkpoint (GO:0000076)4.36806696
20translational initiation (GO:0006413)4.33123211
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.31881210
22DNA strand elongation (GO:0022616)4.31048903
23telomere maintenance via recombination (GO:0000722)4.21803260
24formation of translation preinitiation complex (GO:0001731)4.21667190
25pseudouridine synthesis (GO:0001522)4.20704147
26cellular protein complex disassembly (GO:0043624)4.17787985
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.16797698
28viral life cycle (GO:0019058)4.05775999
29ribosomal small subunit biogenesis (GO:0042274)4.04597205
30GMP metabolic process (GO:0046037)3.99087662
31nucleobase biosynthetic process (GO:0046112)3.98513100
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.97825331
33translation (GO:0006412)3.97430821
34purine nucleobase biosynthetic process (GO:0009113)3.94167565
35ribonucleoprotein complex biogenesis (GO:0022613)3.83033300
36mitotic recombination (GO:0006312)3.83019604
37folic acid-containing compound biosynthetic process (GO:0009396)3.82108268
38folic acid metabolic process (GO:0046655)3.75741533
39protein complex disassembly (GO:0043241)3.72285002
40spliceosomal snRNP assembly (GO:0000387)3.69068144
41protein maturation by protein folding (GO:0022417)3.67198279
42proline biosynthetic process (GO:0006561)3.65763639
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64611911
44macromolecular complex disassembly (GO:0032984)3.63603164
45telomere maintenance via telomere lengthening (GO:0010833)3.57053746
46Golgi transport vesicle coating (GO:0048200)3.53911468
47COPI coating of Golgi vesicle (GO:0048205)3.53911468
48rRNA processing (GO:0006364)3.46952074
49nucleobase-containing small molecule interconversion (GO:0015949)3.45253408
50regulation of cellular amino acid metabolic process (GO:0006521)3.44875023
51DNA unwinding involved in DNA replication (GO:0006268)3.44059651
52IMP biosynthetic process (GO:0006188)3.43989470
53ribosome biogenesis (GO:0042254)3.40312661
54deoxyribonucleotide biosynthetic process (GO:0009263)3.38680901
55rRNA metabolic process (GO:0016072)3.35786083
56pteridine-containing compound biosynthetic process (GO:0042559)3.34441417
57guanosine-containing compound biosynthetic process (GO:1901070)3.33628817
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33558735
59negative regulation of ligase activity (GO:0051352)3.33558735
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.33540043
61ribosome assembly (GO:0042255)3.33224856
62termination of RNA polymerase III transcription (GO:0006386)3.31491518
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.31491518
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.31381423
65positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28343114
66nuclear-transcribed mRNA catabolic process (GO:0000956)3.27628132
67chaperone-mediated protein transport (GO:0072321)3.26729496
68protein targeting to membrane (GO:0006612)3.26231843
69GDP-mannose metabolic process (GO:0019673)3.23480159
70regulation of mitochondrial translation (GO:0070129)3.22126617
71protein targeting to mitochondrion (GO:0006626)3.18924905
72cellular response to zinc ion (GO:0071294)3.17191384
73L-methionine salvage (GO:0071267)3.15639710
74L-methionine biosynthetic process (GO:0071265)3.15639710
75amino acid salvage (GO:0043102)3.15639710
76transcription-coupled nucleotide-excision repair (GO:0006283)3.14651155
77mRNA catabolic process (GO:0006402)3.13715403
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13191030
79positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.13045647
80signal peptide processing (GO:0006465)3.12100846
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11251670
82iron-sulfur cluster assembly (GO:0016226)3.09401603
83metallo-sulfur cluster assembly (GO:0031163)3.09401603
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.08202526
85cellular component biogenesis (GO:0044085)3.06257916
86RNA catabolic process (GO:0006401)3.05836796
87deoxyribonucleotide catabolic process (GO:0009264)3.05297475
88methionine biosynthetic process (GO:0009086)3.03719724
89NIK/NF-kappaB signaling (GO:0038061)3.00968199
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99061515
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99061515
92deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98214354
93spliceosomal complex assembly (GO:0000245)2.94097069
947-methylguanosine mRNA capping (GO:0006370)2.94013828
95antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93251511
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90960243
97DNA replication-dependent nucleosome assembly (GO:0006335)2.89332677
98DNA replication-dependent nucleosome organization (GO:0034723)2.89332677
99nucleotide salvage (GO:0043173)2.89168591
100pyrimidine nucleoside salvage (GO:0043097)2.88926940
101pyrimidine-containing compound salvage (GO:0008655)2.88926940
102establishment of protein localization to mitochondrion (GO:0072655)2.88486911
103tRNA modification (GO:0006400)2.88228319
104cell cycle G1/S phase transition (GO:0044843)2.87947295
105G1/S transition of mitotic cell cycle (GO:0000082)2.87947295
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87931193
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87909909
108signal transduction involved in DNA damage checkpoint (GO:0072422)2.87909909
109regulation of mitochondrial membrane potential (GO:0051881)2.87887237
110signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87756619
111signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87756619
112signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87756619
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.87271888
114regulation of chromatin binding (GO:0035561)2.85080286
115deoxyribose phosphate biosynthetic process (GO:0046385)2.84906315
1162-deoxyribonucleotide biosynthetic process (GO:0009265)2.84906315
117purine deoxyribonucleotide catabolic process (GO:0009155)2.84367716
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.84063092
119virion assembly (GO:0019068)2.83101518
120regulation of oxidative phosphorylation (GO:0002082)2.81812737
121nuclear envelope reassembly (GO:0031468)2.80865643
122mitotic nuclear envelope reassembly (GO:0007084)2.80865643
123regulation of release of cytochrome c from mitochondria (GO:0090199)2.79947108
124mitochondrial fusion (GO:0008053)2.79136489
125signal transduction involved in cell cycle checkpoint (GO:0072395)2.79032613
126activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.78269667
127ATP synthesis coupled proton transport (GO:0015986)2.76131545
128energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76131545
129nucleoside diphosphate biosynthetic process (GO:0009133)2.70975056
130positive regulation of protein homooligomerization (GO:0032464)2.70629117
131rRNA modification (GO:0000154)2.69184004
132protein complex biogenesis (GO:0070271)2.64691947
133peptidyl-arginine omega-N-methylation (GO:0035247)2.62599121
134protein localization to mitochondrion (GO:0070585)2.61533370
135respiratory electron transport chain (GO:0022904)2.59315194
136positive regulation of ligase activity (GO:0051351)2.59283582
137mature B cell differentiation involved in immune response (GO:0002313)2.59213569
138ncRNA 3-end processing (GO:0043628)2.58647912
139mitochondrial calcium ion transport (GO:0006851)2.58259577
140antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.56822108
141regulation of cellular respiration (GO:0043457)2.56498996
142GTP biosynthetic process (GO:0006183)2.55050131
143pentose metabolic process (GO:0019321)2.54208045
144electron transport chain (GO:0022900)2.51764906
145viral protein processing (GO:0019082)2.51473450
146regulation of cellular amine metabolic process (GO:0033238)2.51077225
147oxidative phosphorylation (GO:0006119)2.50952201
148immunoglobulin mediated immune response (GO:0016064)2.50785242
149purine nucleotide salvage (GO:0032261)2.47961981
150negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47137815
151protein deneddylation (GO:0000338)2.46842530
152positive regulation of cell cycle arrest (GO:0071158)2.46756436
153Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46713940
154positive regulation of protein oligomerization (GO:0032461)2.46363293
155nucleoside salvage (GO:0043174)2.45803212
156negative regulation of myeloid cell apoptotic process (GO:0033033)2.44526280
157mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43613425
158cellular zinc ion homeostasis (GO:0006882)2.43515967
159positive regulation of gamma-delta T cell activation (GO:0046645)2.42322303
160positive regulation of lymphocyte apoptotic process (GO:0070230)2.41940990
161cellular response to arsenic-containing substance (GO:0071243)2.40721160
162regulation of autophagic vacuole assembly (GO:2000785)2.39780450
163positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38245615
164T cell apoptotic process (GO:0070231)2.37106969
165AMP metabolic process (GO:0046033)2.36676210
166response to interferon-beta (GO:0035456)2.35797977
167mitochondrial respiratory chain complex assembly (GO:0033108)2.35592148
168mitochondrion morphogenesis (GO:0070584)2.33005623
169regulation of ubiquitin-protein transferase activity (GO:0051438)2.32480156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90271755
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.35742122
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13930293
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.13651391
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07423901
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.66452264
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58544650
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.46367832
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.35536267
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15950275
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02754628
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.01312524
13MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01268343
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88039040
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77626150
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.71805480
17XRN2_22483619_ChIP-Seq_HELA_Human2.60989083
18VDR_23849224_ChIP-Seq_CD4+_Human2.60241231
19GATA1_22025678_ChIP-Seq_K562_Human2.44719763
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39082198
21DCP1A_22483619_ChIP-Seq_HELA_Human2.33535885
22GABP_19822575_ChIP-Seq_HepG2_Human2.31552046
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28634600
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22192495
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22087540
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18110427
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17981143
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16824872
29FOXP3_21729870_ChIP-Seq_TREG_Human2.13961878
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13194439
31* TTF2_22483619_ChIP-Seq_HELA_Human2.10690148
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09913982
33ZNF263_19887448_ChIP-Seq_K562_Human2.09497778
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07033833
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.99642098
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99416243
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.98879778
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97919948
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92825456
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.90228016
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89006585
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86052966
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85100946
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83385979
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.78246406
46ELK1_19687146_ChIP-ChIP_HELA_Human1.78149148
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.71244222
48MYC_22102868_ChIP-Seq_BL_Human1.70301250
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69419282
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69043460
51LXR_22292898_ChIP-Seq_THP-1_Human1.67255341
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65721412
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.65425856
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65140748
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.63052525
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62041325
57CIITA_25753668_ChIP-Seq_RAJI_Human1.54290866
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52184275
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.51741848
60TFEB_21752829_ChIP-Seq_HELA_Human1.51674580
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.49735436
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49358624
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.47132799
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46840300
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.44613834
66KDM5A_27292631_Chip-Seq_BREAST_Human1.43991711
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43685343
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.42123028
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41713201
70* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39977130
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39404951
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.37502175
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.36783951
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36251445
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35729884
76BCL6_27268052_Chip-Seq_Bcells_Human1.35688954
77AR_21909140_ChIP-Seq_LNCAP_Human1.35044471
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.34058058
79* MAF_26560356_Chip-Seq_TH2_Human1.33485823
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30970199
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27468844
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27002583
83RACK7_27058665_Chip-Seq_MCF-7_Human1.25006136
84UTX_26944678_Chip-Seq_JUKART_Human1.24632725
85BCOR_27268052_Chip-Seq_Bcells_Human1.24235848
86* CTCF_26484167_Chip-Seq_Bcells_Mouse1.23302563
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22822933
88VDR_21846776_ChIP-Seq_THP-1_Human1.22498380
89P68_20966046_ChIP-Seq_HELA_Human1.21906255
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.21860510
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.20835185
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19705127
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19044818
94MAF_26560356_Chip-Seq_TH1_Human1.17678113
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16635430
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16034196
97* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14840047
98SPI1_23547873_ChIP-Seq_NB4_Human1.14003956
99SA1_27219007_Chip-Seq_ERYTHROID_Human1.13939578
100* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12931760
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12579575
102MYC_18940864_ChIP-ChIP_HL60_Human1.12263053
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12183666
104CTCF_21964334_Chip-Seq_Bcells_Human1.11889155
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10292259
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08376694
107CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07010484
108VDR_24763502_ChIP-Seq_THP-1_Human1.04971611
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04754924
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03487229
111SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02903376
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02593157
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02357091
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02025964
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01458673
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00251533
117CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99092837
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98650543
119ATF3_27146783_Chip-Seq_COLON_Human0.98633749
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98364410
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98061739
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.98008847
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96643353
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96276573
125CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95947944
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94882925
127* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94162622
128* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91040063
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90771490
130TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90725780
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89256879
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.84118967
133* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83951250
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82789619
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82585901
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80943307
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80790203
138TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76000672
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.75084604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.10555751
2MP0003111_abnormal_nucleus_morphology3.70480838
3MP0005058_abnormal_lysosome_morphology3.67307467
4MP0003806_abnormal_nucleotide_metabolis3.66478218
5MP0004957_abnormal_blastocyst_morpholog3.53788192
6MP0003183_abnormal_peptide_metabolism3.31151052
7MP0003123_paternal_imprinting3.30930665
8MP0003077_abnormal_cell_cycle2.85892605
9MP0005451_abnormal_body_composition2.58564530
10MP0008058_abnormal_DNA_repair2.51130002
11MP0009785_altered_susceptibility_to2.50193668
12MP0010094_abnormal_chromosome_stability2.45755098
13MP0002148_abnormal_hypersensitivity_rea2.36823752
14MP0005499_abnormal_olfactory_system2.33051964
15MP0005394_taste/olfaction_phenotype2.33051964
16MP0008007_abnormal_cellular_replicative2.27983409
17MP0003436_decreased_susceptibility_to2.26492900
18MP0008932_abnormal_embryonic_tissue2.25927122
19MP0004510_myositis2.11305598
20MP0005220_abnormal_exocrine_pancreas2.09005226
21MP0005025_abnormal_response_to2.08479193
22MP0000678_abnormal_parathyroid_gland2.08003923
23MP0005000_abnormal_immune_tolerance2.07110466
24MP0002132_abnormal_respiratory_system2.07017045
25MP0000685_abnormal_immune_system1.98544716
26MP0001790_abnormal_immune_system1.88954222
27MP0005387_immune_system_phenotype1.88954222
28MP0008004_abnormal_stomach_pH1.88326390
29MP0002396_abnormal_hematopoietic_system1.87255082
30MP0006072_abnormal_retinal_apoptosis1.87051632
31MP0000343_altered_response_to1.85512230
32MP0006292_abnormal_olfactory_placode1.83014703
33MP0008057_abnormal_DNA_replication1.79197503
34MP0000490_abnormal_crypts_of1.78078245
35MP0009333_abnormal_splenocyte_physiolog1.75590608
36MP0003315_abnormal_perineum_morphology1.75003157
37MP0000350_abnormal_cell_proliferation1.74942413
38MP0002653_abnormal_ependyma_morphology1.74252127
39MP0001800_abnormal_humoral_immune1.73948589
40MP0008789_abnormal_olfactory_epithelium1.72667753
41MP0002452_abnormal_antigen_presenting1.66594271
42MP0003763_abnormal_thymus_physiology1.62967086
43MP0000703_abnormal_thymus_morphology1.62719563
44MP0005171_absent_coat_pigmentation1.62254360
45MP0002419_abnormal_innate_immunity1.60783030
46MP0001944_abnormal_pancreas_morphology1.60754263
47MP0000358_abnormal_cell_content/1.58013272
48MP0002138_abnormal_hepatobiliary_system1.55219281
49MP0006054_spinal_hemorrhage1.54138631
50MP0000681_abnormal_thyroid_gland1.51956079
51MP0001845_abnormal_inflammatory_respons1.49683969
52MP0003191_abnormal_cellular_cholesterol1.48617807
53MP0009840_abnormal_foam_cell1.46827362
54MP0003075_altered_response_to1.46632880
55MP0001730_embryonic_growth_arrest1.46344580
56MP0008469_abnormal_protein_level1.45170743
57MP0010155_abnormal_intestine_physiology1.45077280
58MP0008260_abnormal_autophagy1.44386507
59MP0004947_skin_inflammation1.42001625
60MP0005464_abnormal_platelet_physiology1.41174760
61MP0006082_CNS_inflammation1.39821150
62MP0002796_impaired_skin_barrier1.38036722
63MP0005166_decreased_susceptibility_to1.35966715
64MP0003011_delayed_dark_adaptation1.35947497
65MP0003786_premature_aging1.34165163
66MP0000313_abnormal_cell_death1.33867212
67MP0002166_altered_tumor_susceptibility1.31202914
68MP0005379_endocrine/exocrine_gland_phen1.28698439
69MP0004043_abnormal_pH_regulation1.28554291
70MP0002877_abnormal_melanocyte_morpholog1.28230060
71MP0002019_abnormal_tumor_incidence1.28216770
72MP0002693_abnormal_pancreas_physiology1.27317496
73MP0004133_heterotaxia1.26980156
74MP0005084_abnormal_gallbladder_morpholo1.26551529
75MP0009764_decreased_sensitivity_to1.25367304
76MP0005397_hematopoietic_system_phenotyp1.22862348
77MP0001545_abnormal_hematopoietic_system1.22862348
78MP0010234_abnormal_vibrissa_follicle1.22397915
79MP0003121_genomic_imprinting1.22396810
80MP0002398_abnormal_bone_marrow1.20844019
81MP0001873_stomach_inflammation1.20652365
82MP0002277_abnormal_respiratory_mucosa1.19607038
83MP0003724_increased_susceptibility_to1.19508507
84MP0003186_abnormal_redox_activity1.18988690
85MP0002751_abnormal_autonomic_nervous1.18346979
86MP0001849_ear_inflammation1.17974493
87MP0001764_abnormal_homeostasis1.17163819
88MP0001984_abnormal_olfaction1.16871384
89MP0002080_prenatal_lethality1.15629497
90MP0003303_peritoneal_inflammation1.14862837
91MP0000750_abnormal_muscle_regeneration1.14420848
92MP0000858_altered_metastatic_potential1.13235598
93MP0010307_abnormal_tumor_latency1.10957349
94MP0004264_abnormal_extraembryonic_tissu1.10866776
95MP0001697_abnormal_embryo_size1.10562087
96MP0005501_abnormal_skin_physiology1.09984896
97MP0005384_cellular_phenotype1.08386051
98MP0002405_respiratory_system_inflammati1.07139785
99MP0002254_reproductive_system_inflammat1.06364254
100MP0002638_abnormal_pupillary_reflex1.06080872
101MP0001542_abnormal_bone_strength1.05543964
102MP0001661_extended_life_span1.04236850
103MP0010352_gastrointestinal_tract_polyps1.04159176
104MP0000749_muscle_degeneration1.03593282
105MP0005319_abnormal_enzyme/_coenzyme1.02260777
106MP0001905_abnormal_dopamine_level1.01375266
107MP0002722_abnormal_immune_system1.01173109
108MP0001293_anophthalmia1.00635503
109MP0005410_abnormal_fertilization0.99577008
110MP0001533_abnormal_skeleton_physiology0.98407759
111MP0009379_abnormal_foot_pigmentation0.98298289
112MP0000689_abnormal_spleen_morphology0.97514191
113MP0005360_urolithiasis0.97084171
114MP0001919_abnormal_reproductive_system0.97060231
115MP0002429_abnormal_blood_cell0.96718498
116MP0005075_abnormal_melanosome_morpholog0.94655285
117MP0005621_abnormal_cell_physiology0.94604402
118MP0003984_embryonic_growth_retardation0.94517824
119MP0002837_dystrophic_cardiac_calcinosis0.94288843
120MP0005330_cardiomyopathy0.93609869
121MP0001835_abnormal_antigen_presentation0.93408588
122MP0006036_abnormal_mitochondrial_physio0.92340842
123MP0004808_abnormal_hematopoietic_stem0.91024838
124MP0008875_abnormal_xenobiotic_pharmacok0.90713211
125MP0004233_abnormal_muscle_weight0.90184506
126MP0005165_increased_susceptibility_to0.88569244
127MP0009697_abnormal_copulation0.88471131
128MP0005671_abnormal_response_to0.88234257
129MP0010030_abnormal_orbit_morphology0.86701579
130MP0002088_abnormal_embryonic_growth/wei0.86337200
131MP0005253_abnormal_eye_physiology0.84859362
132MP0008961_abnormal_basal_metabolism0.84386641
133MP0010368_abnormal_lymphatic_system0.83991195
134MP0001672_abnormal_embryogenesis/_devel0.82693252
135MP0005380_embryogenesis_phenotype0.82693252
136MP0003172_abnormal_lysosome_physiology0.81922742
137MP0003866_abnormal_defecation0.81917664
138MP0008877_abnormal_DNA_methylation0.81185507
139MP0005584_abnormal_enzyme/coenzyme_acti0.80696200
140MP0003718_maternal_effect0.80184465
141MP0001819_abnormal_immune_cell0.79242598
142MP0005310_abnormal_salivary_gland0.79051890
143MP0001324_abnormal_eye_pigmentation0.78763891
144MP0005391_vision/eye_phenotype0.78203456
145MP0002420_abnormal_adaptive_immunity0.77557870
146MP0002006_tumorigenesis0.77529743
147MP0000716_abnormal_immune_system0.77528533
148MP0003122_maternal_imprinting0.77422031
149MP0000747_muscle_weakness0.77038669
150MP0003453_abnormal_keratinocyte_physiol0.77017734
151MP0006035_abnormal_mitochondrial_morpho0.74335959
152MP0003448_altered_tumor_morphology0.73710359
153MP0002163_abnormal_gland_morphology0.73546787
154MP0009763_increased_sensitivity_to0.73424751
155MP0000613_abnormal_salivary_gland0.72681686
156MP0002085_abnormal_embryonic_tissue0.70340203
157MP0004142_abnormal_muscle_tone0.69968416
158MP0003943_abnormal_hepatobiliary_system0.69899102
159MP0000631_abnormal_neuroendocrine_gland0.69374641
160MP0001853_heart_inflammation0.68726187
161MP0000013_abnormal_adipose_tissue0.67758811
162MP0003119_abnormal_digestive_system0.67617752
163MP0002723_abnormal_immune_serum0.67330105

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.63978701
2Abnormal number of erythroid precursors (HP:0012131)4.42332746
3Reticulocytopenia (HP:0001896)4.03602897
4Macrocytic anemia (HP:0001972)3.94132594
5Breast hypoplasia (HP:0003187)3.85723782
6Thrombocytosis (HP:0001894)3.81973958
7Aplastic anemia (HP:0001915)3.52820345
8Abnormality of the anterior horn cell (HP:0006802)3.50582397
9Degeneration of anterior horn cells (HP:0002398)3.50582397
10Carpal bone hypoplasia (HP:0001498)3.40190391
11Megaloblastic anemia (HP:0001889)3.37847254
12Pallor (HP:0000980)3.37409326
13Lipid accumulation in hepatocytes (HP:0006561)3.26381631
14Ragged-red muscle fibers (HP:0003200)3.26074693
15Type I transferrin isoform profile (HP:0003642)3.07808931
16Cerebral hypomyelination (HP:0006808)3.06772855
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06366150
18Increased hepatocellular lipid droplets (HP:0006565)3.01749439
19Microretrognathia (HP:0000308)2.83500578
20Birth length less than 3rd percentile (HP:0003561)2.81590188
21Increased IgM level (HP:0003496)2.80556269
22IgM deficiency (HP:0002850)2.71417178
23Reduced antithrombin III activity (HP:0001976)2.65432289
24Spinal muscular atrophy (HP:0007269)2.58791649
25Severe visual impairment (HP:0001141)2.56397824
26Vertebral compression fractures (HP:0002953)2.53134759
27Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.52063288
28Elevated erythrocyte sedimentation rate (HP:0003565)2.51931456
29Mitochondrial inheritance (HP:0001427)2.51641755
30Secondary amenorrhea (HP:0000869)2.49688877
31Increased CSF lactate (HP:0002490)2.46353808
32Hepatocellular necrosis (HP:0001404)2.42877005
33Recurrent bacterial skin infections (HP:0005406)2.42609887
34Abnormality of endocrine pancreas physiology (HP:0012093)2.40521774
35Abnormality of the pancreatic islet cells (HP:0006476)2.40521774
36Exertional dyspnea (HP:0002875)2.39983095
37Recurrent abscess formation (HP:0002722)2.38862330
38Abnormality of macrophages (HP:0004311)2.38779427
39Hypoplasia of the uterus (HP:0000013)2.38265131
40Agnosia (HP:0010524)2.38255980
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37500108
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37500108
43Exercise intolerance (HP:0003546)2.36968182
44Bulbar palsy (HP:0001283)2.36037082
45Hepatic necrosis (HP:0002605)2.35449237
46Testicular atrophy (HP:0000029)2.35307167
47Colon cancer (HP:0003003)2.35143649
48Abnormal pancreas size (HP:0012094)2.35087657
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.34983303
50Abnormal protein N-linked glycosylation (HP:0012347)2.34983303
51Abnormal protein glycosylation (HP:0012346)2.34983303
52Abnormal glycosylation (HP:0012345)2.34983303
53Acute necrotizing encephalopathy (HP:0006965)2.34896192
54Mediastinal lymphadenopathy (HP:0100721)2.34879739
55Increased serum lactate (HP:0002151)2.30531928
56Microvesicular hepatic steatosis (HP:0001414)2.30516862
57Oral leukoplakia (HP:0002745)2.30087389
58Pancytopenia (HP:0001876)2.28413991
59Progressive neurologic deterioration (HP:0002344)2.27969506
60Prolonged neonatal jaundice (HP:0006579)2.27767841
61Trismus (HP:0000211)2.26979976
62Petechiae (HP:0000967)2.26065634
63Poor head control (HP:0002421)2.24226774
64CNS hypomyelination (HP:0003429)2.23727977
65IgG deficiency (HP:0004315)2.23580477
66Granulocytopenia (HP:0001913)2.22544486
67Postnatal microcephaly (HP:0005484)2.22295530
68Unsteady gait (HP:0002317)2.21675023
69Acute hepatic failure (HP:0006554)2.21528005
70Vacuolated lymphocytes (HP:0001922)2.21167614
713-Methylglutaconic aciduria (HP:0003535)2.20431723
72Abnormality of T cell physiology (HP:0011840)2.18860673
73Abnormal mitochondria in muscle tissue (HP:0008316)2.18029688
74Delayed CNS myelination (HP:0002188)2.15510683
75Aplasia/hypoplasia of the uterus (HP:0008684)2.15271870
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.14865676
77Abnormality of liposaccharide metabolism (HP:0010968)2.13756739
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.13756739
79Abnormality of glycolipid metabolism (HP:0010969)2.13756739
80Rhabdomyolysis (HP:0003201)2.12663709
81Abnormality of B cell number (HP:0010975)2.12545279
82B lymphocytopenia (HP:0010976)2.12545279
83Progressive macrocephaly (HP:0004481)2.11532746
84Obstructive lung disease (HP:0006536)2.06969474
85Chronic obstructive pulmonary disease (HP:0006510)2.06969474
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06813749
87Rough bone trabeculation (HP:0100670)2.05501801
88Acute encephalopathy (HP:0006846)2.04762392
89Increased cerebral lipofuscin (HP:0011813)2.04458035
90Hepatosplenomegaly (HP:0001433)2.03158825
91Abnormal trabecular bone morphology (HP:0100671)2.01553558
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00613241
93Horseshoe kidney (HP:0000085)1.99590373
94Abnormality of the columella (HP:0009929)1.99183897
95Eosinophilia (HP:0001880)1.98821905
96Respiratory failure (HP:0002878)1.98739248
97Generalized aminoaciduria (HP:0002909)1.98114963
98Abnormal hemoglobin (HP:0011902)1.97621888
99Neoplasm of the pancreas (HP:0002894)1.96967064
100Gastrointestinal stroma tumor (HP:0100723)1.96486645
101Hypoglycemic seizures (HP:0002173)1.96318758
102Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95381553
103Abnormality of the heme biosynthetic pathway (HP:0010472)1.95331453
104Premature graying of hair (HP:0002216)1.94798993
105Recurrent viral infections (HP:0004429)1.94668055
106Increased serum ferritin (HP:0003281)1.94620514
107Progressive muscle weakness (HP:0003323)1.94611153
108Homocystinuria (HP:0002156)1.94576941
109Abnormality of homocysteine metabolism (HP:0010919)1.94576941
110Hypertensive crisis (HP:0100735)1.92825380
111Spastic paraparesis (HP:0002313)1.92229330
112Renal Fanconi syndrome (HP:0001994)1.91974433
113Autoimmune thrombocytopenia (HP:0001973)1.90806776
114Abnormality of T cells (HP:0002843)1.90683041
115Distal lower limb muscle weakness (HP:0009053)1.90262797
116Tongue fasciculations (HP:0001308)1.90215320
117Increased muscle lipid content (HP:0009058)1.89481204
118Chronic otitis media (HP:0000389)1.87065722
119Myopathic facies (HP:0002058)1.85896291
120Optic nerve coloboma (HP:0000588)1.85719952
121Hyperinsulinemic hypoglycemia (HP:0000825)1.85375658
122Hypokinesia (HP:0002375)1.84185774
123Increased intramyocellular lipid droplets (HP:0012240)1.84006441
124Esophageal neoplasm (HP:0100751)1.83885865
125Neoplasm of head and neck (HP:0012288)1.83885865
126Aplasia/Hypoplasia of the patella (HP:0006498)1.83722518
127Emotional lability (HP:0000712)1.83473934
128Hyperphosphaturia (HP:0003109)1.83158074
129Generalized amyotrophy (HP:0003700)1.82852593
130Diaphragmatic weakness (HP:0009113)1.82779244
131Cerebral edema (HP:0002181)1.82760075
132Lactic acidosis (HP:0003128)1.82739904
133Fasciculations (HP:0002380)1.81909152
134Axonal loss (HP:0003447)1.81289755
135Lymphoma (HP:0002665)1.80313350
136Stenosis of the external auditory canal (HP:0000402)1.80234659
137Respiratory difficulties (HP:0002880)1.79608077
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79492844
139Pustule (HP:0200039)1.78497986
140Urinary glycosaminoglycan excretion (HP:0003541)1.77979564
141Mucopolysacchariduria (HP:0008155)1.77979564
142Dysostosis multiplex (HP:0000943)1.76662576
143Absent thumb (HP:0009777)1.76619005
144Inflammation of the large intestine (HP:0002037)1.76594145
145Colitis (HP:0002583)1.76281277
146Gastrointestinal inflammation (HP:0004386)1.76160030
147Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.76022310
148Muscle fibrillation (HP:0010546)1.75924582
149Achilles tendon contracture (HP:0001771)1.74475215
150Thoracic kyphosis (HP:0002942)1.74249191
151T lymphocytopenia (HP:0005403)1.73626290
152Meckel diverticulum (HP:0002245)1.73056599
153Cleft eyelid (HP:0000625)1.72639197
154Patellar aplasia (HP:0006443)1.72496157
155Hypoplasia of the thymus (HP:0000778)1.72456204
156Intestinal atresia (HP:0011100)1.71501358
15711 pairs of ribs (HP:0000878)1.70733526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.72780883
2BUB14.57500124
3EIF2AK34.28410289
4STK164.02830659
5VRK23.66138445
6NME23.02969134
7SRPK12.92016036
8WEE12.80666112
9MKNK22.40755711
10SIK32.16409062
11SCYL22.15573766
12LIMK12.13039341
13ACVR1B2.09391876
14WNK32.08081951
15TSSK62.07910721
16SMG12.03169150
17MAP4K11.84232637
18MKNK11.82988147
19BRSK21.77328824
20PASK1.76234439
21VRK11.75881872
22CSNK1G31.74602390
23PINK11.72736975
24TBK11.70237028
25TNIK1.65689913
26CDC71.64221122
27CDK191.56900989
28EIF2AK11.55201788
29RPS6KA41.53311779
30CSNK1A1L1.48521676
31CLK11.46768050
32PBK1.34538617
33DYRK31.33038396
34MAP3K121.32523039
35CSNK1G11.27625500
36MARK31.25348197
37DAPK31.24385972
38ABL21.20210896
39MAP3K131.20171250
40TESK21.20132056
41MAP3K111.14852504
42ILK1.14453104
43TRIB31.13219239
44MAPK111.12351825
45MYLK1.10344308
46KDR1.09333255
47PRPF4B1.08447946
48FLT31.07993661
49CSNK1G21.05397853
50TAOK21.02396125
51PLK11.02228752
52ZAP701.01636687
53RPS6KA51.00079962
54MAPKAPK30.98195342
55FES0.95753278
56IKBKB0.93898374
57NEK10.93228046
58CDK80.93025707
59CDK70.91504099
60DAPK10.90845658
61NME10.89130427
62PLK30.87914911
63EPHB20.87374602
64MOS0.85951947
65MAP3K80.85684285
66PIM20.85300468
67MAP3K10.85070554
68BCKDK0.84829486
69BRSK10.84341493
70IKBKE0.84202712
71BTK0.84049651
72BRAF0.82897039
73PRKCI0.82605661
74TTK0.81563172
75BLK0.80888677
76TGFBR10.78763781
77MELK0.77263215
78IRAK40.77182685
79AURKA0.76810787
80PRKG20.76692471
81MARK20.76350041
82FRK0.75559306
83PAK10.73902213
84AURKB0.73212364
85MAP3K140.72146351
86GRK60.71763584
87KSR10.71526647
88ITK0.71375980
89PAK40.70910741
90MAP2K30.69944174
91HIPK20.69744229
92NLK0.68691582
93ATR0.67310119
94IRAK20.67271074
95LMTK20.66617691
96ZAK0.66369897
97MAPK150.65047949
98TEC0.64744981
99LRRK20.64578004
100MAP2K70.64210790
101MAP2K60.63116152
102CSK0.62356193
103RPS6KB20.62148307
104TXK0.61133375
105NEK90.61024706
106TNK20.59983166
107ERN10.58468149
108SYK0.58262882
109CSNK2A20.56067606
110TYK20.55748414
111CAMK2B0.55684501
112STK100.55499153
113MAP3K100.55057955
114JAK30.53418362
115TIE10.52105158
116LYN0.51978296
117MAPKAPK20.49408696
118MST40.48249750
119GRK70.47864955
120TESK10.47762986
121MAP3K50.47694304
122IRAK30.47540278
123AKT20.46335977
124ALK0.44868185
125ICK0.43716024
126MAP2K20.42590664
127PDPK10.39721779
128TAOK10.39688514
129NTRK30.39070252
130CSNK2A10.38999091
131ARAF0.38600998
132PRKCQ0.37952420
133MAP3K30.37272823
134CHEK10.36471528
135MUSK0.35694485
136CHEK20.35548863
137CDK40.34408962
138PIM10.34040713
139EPHA20.33908181
140CCNB10.32162223
141PRKD30.31699761
142BMPR20.30618931
143BRD40.30308587
144UHMK10.29449721
145CAMKK20.29386992
146CSF1R0.28938714
147MINK10.28852710
148YES10.28836912
149CAMK2G0.28223623
150GRK50.27673817
151CDK90.27538220
152NEK20.25158187
153LCK0.24392624
154BMX0.23571567
155PDK20.23303027

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88809602
2Ribosome_Homo sapiens_hsa030104.76042468
3Proteasome_Homo sapiens_hsa030503.96930969
4Protein export_Homo sapiens_hsa030603.72192312
5Mismatch repair_Homo sapiens_hsa034303.40021775
6RNA polymerase_Homo sapiens_hsa030203.27338649
7Spliceosome_Homo sapiens_hsa030403.14098945
8Base excision repair_Homo sapiens_hsa034102.86875702
9Pyrimidine metabolism_Homo sapiens_hsa002402.71371200
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69540584
11Homologous recombination_Homo sapiens_hsa034402.31136596
12One carbon pool by folate_Homo sapiens_hsa006702.30501713
13RNA transport_Homo sapiens_hsa030132.28156445
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.26301691
15Nucleotide excision repair_Homo sapiens_hsa034202.23944714
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06252628
17Folate biosynthesis_Homo sapiens_hsa007901.88222319
18Cell cycle_Homo sapiens_hsa041101.87539877
19Sulfur relay system_Homo sapiens_hsa041221.82762502
20Purine metabolism_Homo sapiens_hsa002301.77866042
21Graft-versus-host disease_Homo sapiens_hsa053321.67974276
22Allograft rejection_Homo sapiens_hsa053301.64412604
23Autoimmune thyroid disease_Homo sapiens_hsa053201.49893153
24Basal transcription factors_Homo sapiens_hsa030221.41833536
25Non-homologous end-joining_Homo sapiens_hsa034501.41057777
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35846334
27RNA degradation_Homo sapiens_hsa030181.34373326
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.26837408
29Fatty acid elongation_Homo sapiens_hsa000621.26405728
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25661396
31Selenocompound metabolism_Homo sapiens_hsa004501.25564433
32Fanconi anemia pathway_Homo sapiens_hsa034601.25433357
33Rheumatoid arthritis_Homo sapiens_hsa053231.21856325
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.18275771
35Apoptosis_Homo sapiens_hsa042101.16195856
36N-Glycan biosynthesis_Homo sapiens_hsa005101.09455808
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.08921394
38mRNA surveillance pathway_Homo sapiens_hsa030151.02122294
39Antigen processing and presentation_Homo sapiens_hsa046121.01496251
40Caffeine metabolism_Homo sapiens_hsa002321.00820284
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99190098
42Epstein-Barr virus infection_Homo sapiens_hsa051690.98962062
43Asthma_Homo sapiens_hsa053100.98098676
44Oxidative phosphorylation_Homo sapiens_hsa001900.96868722
45Parkinsons disease_Homo sapiens_hsa050120.95475224
46Phagosome_Homo sapiens_hsa041450.95242836
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94176228
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91029741
49Hematopoietic cell lineage_Homo sapiens_hsa046400.90397051
50Viral myocarditis_Homo sapiens_hsa054160.88709930
51Herpes simplex infection_Homo sapiens_hsa051680.86600776
52Legionellosis_Homo sapiens_hsa051340.85245174
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85056882
54Pentose phosphate pathway_Homo sapiens_hsa000300.84700303
55Leishmaniasis_Homo sapiens_hsa051400.83680968
56Vibrio cholerae infection_Homo sapiens_hsa051100.82792568
57Salmonella infection_Homo sapiens_hsa051320.79256347
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76794510
59p53 signaling pathway_Homo sapiens_hsa041150.76274956
60Sulfur metabolism_Homo sapiens_hsa009200.75439844
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.75236717
62Tuberculosis_Homo sapiens_hsa051520.75095796
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74863425
64Huntingtons disease_Homo sapiens_hsa050160.70819827
65Regulation of autophagy_Homo sapiens_hsa041400.69391082
66Glutathione metabolism_Homo sapiens_hsa004800.68190383
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66301345
68Oocyte meiosis_Homo sapiens_hsa041140.64351282
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64004714
70Phototransduction_Homo sapiens_hsa047440.63470860
71Osteoclast differentiation_Homo sapiens_hsa043800.63337455
72Primary immunodeficiency_Homo sapiens_hsa053400.63309259
73Systemic lupus erythematosus_Homo sapiens_hsa053220.63032231
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62504783
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62238077
76Shigellosis_Homo sapiens_hsa051310.61430715
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60918807
78Phenylalanine metabolism_Homo sapiens_hsa003600.58941137
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58716189
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56566555
81Pertussis_Homo sapiens_hsa051330.55696410
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54250606
83Thyroid cancer_Homo sapiens_hsa052160.52890788
84Galactose metabolism_Homo sapiens_hsa000520.52355451
85Influenza A_Homo sapiens_hsa051640.52061467
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.50641506
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48601171
88Peroxisome_Homo sapiens_hsa041460.48516170
89Alzheimers disease_Homo sapiens_hsa050100.47016322
90HTLV-I infection_Homo sapiens_hsa051660.43131526
91Other glycan degradation_Homo sapiens_hsa005110.42982320
92Staphylococcus aureus infection_Homo sapiens_hsa051500.42814247
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42282395
94TNF signaling pathway_Homo sapiens_hsa046680.42033433
95Prion diseases_Homo sapiens_hsa050200.41659590
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41148328
97Metabolic pathways_Homo sapiens_hsa011000.41068005
98Alcoholism_Homo sapiens_hsa050340.40890190
99Viral carcinogenesis_Homo sapiens_hsa052030.38387718
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35395425
101Circadian rhythm_Homo sapiens_hsa047100.34535451
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.33573184
103Sphingolipid metabolism_Homo sapiens_hsa006000.33365499
104Amphetamine addiction_Homo sapiens_hsa050310.32289577
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31967851
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31759647
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31079572
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28936394
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27643515
110Acute myeloid leukemia_Homo sapiens_hsa052210.27523477
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25232255
112Bladder cancer_Homo sapiens_hsa052190.24405474
113Biosynthesis of amino acids_Homo sapiens_hsa012300.24388689
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23775409
115Vitamin digestion and absorption_Homo sapiens_hsa049770.21824732
116Long-term potentiation_Homo sapiens_hsa047200.20104393
117Hepatitis B_Homo sapiens_hsa051610.19495288
118Lysosome_Homo sapiens_hsa041420.19467767
119Renin-angiotensin system_Homo sapiens_hsa046140.19312132
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18993172
121Notch signaling pathway_Homo sapiens_hsa043300.18508771
122Collecting duct acid secretion_Homo sapiens_hsa049660.17282320
123Fructose and mannose metabolism_Homo sapiens_hsa000510.16385238
124Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13780906
125Carbon metabolism_Homo sapiens_hsa012000.13701584
126Type I diabetes mellitus_Homo sapiens_hsa049400.13676162
127Measles_Homo sapiens_hsa051620.11972718
128B cell receptor signaling pathway_Homo sapiens_hsa046620.11960193
129Prostate cancer_Homo sapiens_hsa052150.11596034
130T cell receptor signaling pathway_Homo sapiens_hsa046600.10907976
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09482890

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