OTUD6A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)6.88434589
2cell wall macromolecule catabolic process (GO:0016998)6.64330778
3cell wall macromolecule metabolic process (GO:0044036)6.64330778
4nuclear pore complex assembly (GO:0051292)5.57410668
5nuclear pore organization (GO:0006999)5.51371600
6acrosome assembly (GO:0001675)5.40997888
7response to pheromone (GO:0019236)5.20346258
8sperm-egg recognition (GO:0035036)5.08177157
9plasma membrane fusion (GO:0045026)5.07236369
10binding of sperm to zona pellucida (GO:0007339)5.05637877
11synaptonemal complex assembly (GO:0007130)4.90723575
12piRNA metabolic process (GO:0034587)4.70180290
13sperm motility (GO:0030317)4.66636020
14regulation of gene silencing by RNA (GO:0060966)4.58275002
15regulation of posttranscriptional gene silencing (GO:0060147)4.58275002
16regulation of gene silencing by miRNA (GO:0060964)4.58275002
17behavioral response to nicotine (GO:0035095)4.55816542
18cell-cell recognition (GO:0009988)4.50051526
19L-fucose catabolic process (GO:0042355)4.49720515
20fucose catabolic process (GO:0019317)4.49720515
21L-fucose metabolic process (GO:0042354)4.49720515
22multicellular organism reproduction (GO:0032504)4.43102387
23synaptonemal complex organization (GO:0070193)4.41565174
24microtubule depolymerization (GO:0007019)4.38681300
25pore complex assembly (GO:0046931)4.32896081
26DNA replication-dependent nucleosome assembly (GO:0006335)4.28213220
27DNA replication-dependent nucleosome organization (GO:0034723)4.28213220
28chromosome organization involved in meiosis (GO:0070192)4.24279234
29spermatid development (GO:0007286)4.22180713
30male meiosis (GO:0007140)4.21187352
31mitotic sister chromatid segregation (GO:0000070)4.17780768
32protein localization to kinetochore (GO:0034501)4.14418062
33DNA replication checkpoint (GO:0000076)4.05421903
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.97646746
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.97646746
36epithelial cilium movement (GO:0003351)3.97321523
37protein localization to chromosome, centromeric region (GO:0071459)3.97160125
38heterochromatin organization (GO:0070828)3.88067302
39detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.87120138
40protein-cofactor linkage (GO:0018065)3.86707490
41mitotic nuclear envelope disassembly (GO:0007077)3.85484967
42chaperone-mediated protein complex assembly (GO:0051131)3.85326182
43respiratory chain complex IV assembly (GO:0008535)3.84359447
44DNA replication initiation (GO:0006270)3.78808762
45sister chromatid cohesion (GO:0007062)3.75214664
46sister chromatid segregation (GO:0000819)3.73509169
47reproduction (GO:0000003)3.73203358
48histone H4-K12 acetylation (GO:0043983)3.70734054
49membrane disassembly (GO:0030397)3.67088324
50nuclear envelope disassembly (GO:0051081)3.67088324
51regulation of glucokinase activity (GO:0033131)3.66350911
52regulation of hexokinase activity (GO:1903299)3.66350911
53meiotic nuclear division (GO:0007126)3.64227598
54axonemal dynein complex assembly (GO:0070286)3.62079629
55chromosome condensation (GO:0030261)3.60629505
56negative regulation of histone methylation (GO:0031061)3.60021207
57regulation of telomere maintenance via telomerase (GO:0032210)3.59805386
58mitotic sister chromatid cohesion (GO:0007064)3.59751271
59DNA unwinding involved in DNA replication (GO:0006268)3.59239751
60DNA methylation involved in gamete generation (GO:0043046)3.58459518
61DNA deamination (GO:0045006)3.58087490
62regulation of histone H3-K9 methylation (GO:0051570)3.55959047
63motile cilium assembly (GO:0044458)3.52767226
64platelet dense granule organization (GO:0060155)3.50734009
65negative regulation of telomere maintenance (GO:0032205)3.50160867
66regulation of helicase activity (GO:0051095)3.49784283
67protein complex biogenesis (GO:0070271)3.49397822
68regulation of meiosis I (GO:0060631)3.46323122
69folic acid-containing compound biosynthetic process (GO:0009396)3.42816637
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.40994570
71NADH dehydrogenase complex assembly (GO:0010257)3.40994570
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40994570
73cytochrome complex assembly (GO:0017004)3.40140541
74DNA geometric change (GO:0032392)3.39618164
75DNA duplex unwinding (GO:0032508)3.39593560
76regulation of nuclear cell cycle DNA replication (GO:0033262)3.39501431
77DNA packaging (GO:0006323)3.38079814
78water-soluble vitamin biosynthetic process (GO:0042364)3.37978572
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37297861
80synapsis (GO:0007129)3.35065760
81protein K6-linked ubiquitination (GO:0085020)3.33732306
82axoneme assembly (GO:0035082)3.33251700
83indole-containing compound catabolic process (GO:0042436)3.33245129
84indolalkylamine catabolic process (GO:0046218)3.33245129
85tryptophan catabolic process (GO:0006569)3.33245129
86* protein K11-linked deubiquitination (GO:0035871)3.29015500
87reciprocal DNA recombination (GO:0035825)3.28779423
88reciprocal meiotic recombination (GO:0007131)3.28779423
89determination of adult lifespan (GO:0008340)3.28018010
90negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.27699263
91proline transport (GO:0015824)3.27473303
92paraxial mesoderm development (GO:0048339)3.23661058
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21966275
94acrosome reaction (GO:0007340)3.21366820
95neural tube formation (GO:0001841)3.20766844
96establishment of apical/basal cell polarity (GO:0035089)3.20687599
97IMP biosynthetic process (GO:0006188)3.19149152
98mitochondrial respiratory chain complex assembly (GO:0033108)3.19145356
99detection of light stimulus involved in visual perception (GO:0050908)3.18964199
100detection of light stimulus involved in sensory perception (GO:0050962)3.18964199
101DNA conformation change (GO:0071103)3.18658217
102mitotic metaphase plate congression (GO:0007080)3.16920438
103pre-miRNA processing (GO:0031054)3.16787118
104nucleobase biosynthetic process (GO:0046112)3.15374841
105glycerophospholipid catabolic process (GO:0046475)3.15261577
106kynurenine metabolic process (GO:0070189)3.14925080
107indolalkylamine metabolic process (GO:0006586)3.13937048
108germ cell development (GO:0007281)3.09891934
109regulation of translational fidelity (GO:0006450)3.09382934
110meiotic cell cycle process (GO:1903046)3.09255698
111single strand break repair (GO:0000012)3.09121825
112regulation of chromosome segregation (GO:0051983)3.09047683
113nonmotile primary cilium assembly (GO:0035058)3.08952600
114intra-S DNA damage checkpoint (GO:0031573)3.08362494
115DNA strand elongation involved in DNA replication (GO:0006271)3.08223193
116fertilization (GO:0009566)3.07963622
117adaptation of signaling pathway (GO:0023058)3.05196565
118negative regulation of DNA repair (GO:0045738)3.03779780
119cilium morphogenesis (GO:0060271)3.03209964
120cellular ketone body metabolic process (GO:0046950)3.03169300
121regulation of protein polyubiquitination (GO:1902914)3.01938025
122xenobiotic catabolic process (GO:0042178)3.01644314
123photoreceptor cell maintenance (GO:0045494)3.01202491
124positive regulation of chromosome segregation (GO:0051984)3.01134512
125regulation of cilium movement (GO:0003352)2.99905120
126spermatogenesis (GO:0007283)2.99315565
127male gamete generation (GO:0048232)2.99102023
128regulation of centriole replication (GO:0046599)2.97327219
129spindle assembly involved in mitosis (GO:0090307)2.96710410
130male meiosis I (GO:0007141)2.95714888
131chromatin assembly (GO:0031497)2.94919332
132histone H4-K8 acetylation (GO:0043982)2.94842056
133histone H4-K5 acetylation (GO:0043981)2.94842056
134preassembly of GPI anchor in ER membrane (GO:0016254)2.93190210
135attachment of spindle microtubules to kinetochore (GO:0008608)2.92780914
136positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.92730911
137positive regulation of mitotic sister chromatid separation (GO:1901970)2.92730911
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.92730911
139cilium movement (GO:0003341)2.92361787
140protein localization to cilium (GO:0061512)2.91506046
141DNA double-strand break processing (GO:0000729)2.89997315
142peptidyl-histidine modification (GO:0018202)2.89830535
143reflex (GO:0060004)2.84466069
144protein polyglutamylation (GO:0018095)2.83841621
145cornea development in camera-type eye (GO:0061303)2.83462283
146phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80629690
147behavioral response to ethanol (GO:0048149)2.79914428
148sulfation (GO:0051923)2.79892832
149tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79525270
150RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79525270
151ketone body metabolic process (GO:1902224)2.76875517
152auditory receptor cell stereocilium organization (GO:0060088)2.76637346
153mannosylation (GO:0097502)2.74851341
154inner ear receptor stereocilium organization (GO:0060122)2.73841835
155recombinational repair (GO:0000725)2.71987329
156regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.71415164
157double-strand break repair via homologous recombination (GO:0000724)2.70667506
158tryptophan metabolic process (GO:0006568)2.70640648
159retinal cone cell development (GO:0046549)2.66839977
160L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64389518
161alanine transport (GO:0032328)2.64122486
162negative regulation of mast cell activation (GO:0033004)2.64101025
163S-adenosylmethionine metabolic process (GO:0046500)2.63934289
164replication fork processing (GO:0031297)2.62918829
165cilium organization (GO:0044782)2.62533058
166regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61909928
167cellular biogenic amine catabolic process (GO:0042402)2.60701170
168amine catabolic process (GO:0009310)2.60701170
169pseudouridine synthesis (GO:0001522)2.60185866
170negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59743389
171inositol phosphate catabolic process (GO:0071545)2.59307748
172cilium assembly (GO:0042384)2.57056253
173rhodopsin mediated signaling pathway (GO:0016056)2.56988618
174gamma-aminobutyric acid transport (GO:0015812)2.53802721
175regulation of telomere maintenance (GO:0032204)2.53597874
176meiotic chromosome segregation (GO:0045132)2.52973753
177polyol catabolic process (GO:0046174)2.52684909
178photoreceptor cell development (GO:0042461)2.50230074
179pyrimidine nucleobase catabolic process (GO:0006208)2.48741224
180negative regulation of DNA-dependent DNA replication (GO:2000104)2.48467968
181startle response (GO:0001964)2.47212406
182RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46996723
183nucleobase catabolic process (GO:0046113)2.46566988
184synaptic transmission, cholinergic (GO:0007271)2.46562282
185kidney morphogenesis (GO:0060993)2.46476185
186positive regulation of mitochondrial fission (GO:0090141)2.45633024
187ubiquinone biosynthetic process (GO:0006744)2.45535098

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37321907
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.56626475
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.52398416
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.52398416
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.52398416
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.25919617
7ZNF274_21170338_ChIP-Seq_K562_Hela4.00068927
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.29063108
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.15945354
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14613457
11VDR_22108803_ChIP-Seq_LS180_Human3.08057934
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.98991682
13GBX2_23144817_ChIP-Seq_PC3_Human2.90520700
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.90294788
15IGF1R_20145208_ChIP-Seq_DFB_Human2.79889191
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79664529
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.66938222
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65127530
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.61324298
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57520367
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46524258
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31349734
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.30078094
24FUS_26573619_Chip-Seq_HEK293_Human2.22839212
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20522369
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16080432
27EWS_26573619_Chip-Seq_HEK293_Human2.14198967
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.13227543
29SOX2_18555785_ChIP-Seq_MESCs_Mouse2.11220304
30TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09693944
31TCF3_18692474_ChIP-Seq_MEFs_Mouse2.08780595
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06833468
33STAT3_1855785_ChIP-Seq_MESCs_Mouse2.06726447
34CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06299772
35P300_19829295_ChIP-Seq_ESCs_Human2.06001572
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.03577521
37TAF15_26573619_Chip-Seq_HEK293_Human2.02826350
38NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00599823
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98735700
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.98149102
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93027009
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88029087
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86641588
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80406982
45ER_23166858_ChIP-Seq_MCF-7_Human1.79977985
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76497412
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75889695
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.72389403
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70335262
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.68549209
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67465433
52TP53_22573176_ChIP-Seq_HFKS_Human1.65110026
53AR_21909140_ChIP-Seq_LNCAP_Human1.65021360
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62798864
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61885512
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61084915
57CBP_20019798_ChIP-Seq_JUKART_Human1.61084915
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.59897461
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58811116
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57929515
61BCAT_22108803_ChIP-Seq_LS180_Human1.57849927
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56918830
63EZH2_22144423_ChIP-Seq_EOC_Human1.56635532
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54954070
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.54574596
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49762180
67MYC_18940864_ChIP-ChIP_HL60_Human1.48885221
68STAT3_23295773_ChIP-Seq_U87_Human1.46859078
69SMAD4_21799915_ChIP-Seq_A2780_Human1.46200220
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45396818
71AR_25329375_ChIP-Seq_VCAP_Human1.45122392
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45020932
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.44080357
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43692474
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.42772279
76NANOG_18692474_ChIP-Seq_MEFs_Mouse1.42387437
77TCF4_23295773_ChIP-Seq_U87_Human1.41785612
78SOX2_18692474_ChIP-Seq_MESCs_Mouse1.41230269
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41182475
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40593867
81XRN2_22483619_ChIP-Seq_HELA_Human1.39130276
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37704689
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37433250
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.36312230
85NANOG_18692474_ChIP-Seq_MESCs_Mouse1.36255588
86NANOG_19829295_ChIP-Seq_ESCs_Human1.36103759
87SOX2_19829295_ChIP-Seq_ESCs_Human1.36103759
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35987220
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34433146
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34407936
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.34407936
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.34152481
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32362007
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32323820
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.32115265
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31980064
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30418895
98ELK1_19687146_ChIP-ChIP_HELA_Human1.30217500
99TCF4_22108803_ChIP-Seq_LS180_Human1.29708105
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29408494
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29312952
102NANOG_21062744_ChIP-ChIP_HESCs_Human1.28208930
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26930956
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26649697
105NANOG_16518401_ChIP-PET_MESCs_Mouse1.26628781
106IRF1_19129219_ChIP-ChIP_H3396_Human1.26326191
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26270914
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26208863
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26208863
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.25724757
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24462644
112TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23581463
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23483847
114E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23023232
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22887995
116CRX_20693478_ChIP-Seq_RETINA_Mouse1.22869063
117CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22441072
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22368763
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21611577
120POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20619537
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.20112252
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.19043730
123KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18680931
124NCOR_22424771_ChIP-Seq_293T_Human1.18667718
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18089779
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17986815
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17940892
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17364416
129HOXB7_26014856_ChIP-Seq_BT474_Human1.17248412
130RUNX2_22187159_ChIP-Seq_PCA_Human1.16953876
131EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16893698
132EST1_17652178_ChIP-ChIP_JURKAT_Human1.15548424
133PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.14036319
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.13120040
135AR_20517297_ChIP-Seq_VCAP_Human1.12285173
136ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11728046
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.10153855
138GATA3_21878914_ChIP-Seq_MCF-7_Human1.10065604
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09995626
140REST_21632747_ChIP-Seq_MESCs_Mouse1.07390522
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07287880
142RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06857127
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06779253
144STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06548201
145P53_22387025_ChIP-Seq_ESCs_Mouse1.06101456
146BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05908466
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05572248
148TP63_19390658_ChIP-ChIP_HaCaT_Human1.04619745
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04450959
150STAT3_18555785_Chip-Seq_ESCs_Mouse1.03580341
151CDX2_22108803_ChIP-Seq_LS180_Human1.03012150
152KAP1_27257070_Chip-Seq_ESCs_Mouse1.02871378
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.02843095
154ETS1_20019798_ChIP-Seq_JURKAT_Human1.02556101
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02511578
156OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01703901
157GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01081721
158CBX2_27304074_Chip-Seq_ESCs_Mouse1.00736495
159POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99621029
160KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97949381
161YY1_21170310_ChIP-Seq_MESCs_Mouse0.96842138
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96734765
163OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95701516
164TTF2_22483619_ChIP-Seq_HELA_Human0.92593050
165KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92415573
166ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92088810
167NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91959337
168RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91263984
169VDR_23849224_ChIP-Seq_CD4+_Human0.87118199
170JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85227712
171KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.84939774
172KDM5A_27292631_Chip-Seq_BREAST_Human0.83650612
173GATA1_26923725_Chip-Seq_HPCs_Mouse0.82279387
174FOXP3_21729870_ChIP-Seq_TREG_Human0.82167604
175BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80159534
176CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77017850
177PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76649207
178ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75087139
179STAT3_18555785_ChIP-Seq_MESCs_Mouse0.74372935
180YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73692702
181FLI1_27457419_Chip-Seq_LIVER_Mouse0.72857989
182HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.70743499
183TBX3_20139965_ChIP-Seq_ESCs_Mouse0.70470053
184E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.69850309
185TBX3_20139965_ChIP-Seq_MESCs_Mouse0.68900319
186TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.68313347
187YY1_22570637_ChIP-Seq_MALME-3M_Human0.66868856
188CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.66344025
189PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66253868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.20604169
2MP0008057_abnormal_DNA_replication5.09485982
3MP0010094_abnormal_chromosome_stability3.95235900
4MP0008877_abnormal_DNA_methylation3.54982170
5MP0003111_abnormal_nucleus_morphology3.49269710
6MP0003195_calcinosis3.21404356
7MP0004957_abnormal_blastocyst_morpholog3.21297208
8MP0008058_abnormal_DNA_repair3.04769251
9MP0003077_abnormal_cell_cycle2.91742229
10MP0001929_abnormal_gametogenesis2.86439400
11MP0002837_dystrophic_cardiac_calcinosis2.70819433
12MP0002653_abnormal_ependyma_morphology2.67519011
13MP0005551_abnormal_eye_electrophysiolog2.66301104
14MP0003698_abnormal_male_reproductive2.65018933
15MP0003693_abnormal_embryo_hatching2.56626307
16MP0000372_irregular_coat_pigmentation2.55056726
17MP0002210_abnormal_sex_determination2.42357725
18MP0004043_abnormal_pH_regulation2.41918355
19MP0006072_abnormal_retinal_apoptosis2.40593350
20MP0002102_abnormal_ear_morphology2.39423161
21MP0003786_premature_aging2.30555794
22MP0003806_abnormal_nucleotide_metabolis2.27503040
23MP0001968_abnormal_touch/_nociception2.26488654
24MP0008875_abnormal_xenobiotic_pharmacok2.26153241
25MP0001145_abnormal_male_reproductive2.25420244
26MP0010352_gastrointestinal_tract_polyps2.23847455
27MP0005646_abnormal_pituitary_gland2.17156469
28MP0002876_abnormal_thyroid_physiology2.09870357
29MP0005253_abnormal_eye_physiology2.02231668
30MP0000350_abnormal_cell_proliferation2.00745745
31MP0001730_embryonic_growth_arrest2.00602364
32MP0008872_abnormal_physiological_respon1.99263130
33MP0001984_abnormal_olfaction1.95074082
34MP0001986_abnormal_taste_sensitivity1.93261665
35MP0000569_abnormal_digit_pigmentation1.90173111
36MP0008007_abnormal_cellular_replicative1.88842161
37MP0010030_abnormal_orbit_morphology1.87975208
38MP0000653_abnormal_sex_gland1.86965687
39MP0010307_abnormal_tumor_latency1.86689798
40MP0003787_abnormal_imprinting1.83477156
41MP0005499_abnormal_olfactory_system1.83347286
42MP0005394_taste/olfaction_phenotype1.83347286
43MP0009046_muscle_twitch1.83158517
44MP0008789_abnormal_olfactory_epithelium1.82773976
45MP0003646_muscle_fatigue1.82273551
46MP0004147_increased_porphyrin_level1.78757379
47MP0005645_abnormal_hypothalamus_physiol1.76110260
48MP0001672_abnormal_embryogenesis/_devel1.75503265
49MP0005380_embryogenesis_phenotype1.75503265
50MP0002938_white_spotting1.74627063
51MP0004133_heterotaxia1.74243011
52MP0002084_abnormal_developmental_patter1.73819226
53MP0003123_paternal_imprinting1.72012000
54MP0002736_abnormal_nociception_after1.71905821
55MP0002163_abnormal_gland_morphology1.71662224
56MP0003890_abnormal_embryonic-extraembry1.71618629
57MP0003880_abnormal_central_pattern1.71469528
58MP0000427_abnormal_hair_cycle1.71131947
59MP0009745_abnormal_behavioral_response1.67116693
60MP0008932_abnormal_embryonic_tissue1.63755319
61MP0002085_abnormal_embryonic_tissue1.61153523
62MP0002877_abnormal_melanocyte_morpholog1.58792586
63MP0000631_abnormal_neuroendocrine_gland1.58257023
64MP0002161_abnormal_fertility/fecundity1.55440880
65MP0003705_abnormal_hypodermis_morpholog1.54555941
66MP0004197_abnormal_fetal_growth/weight/1.53056366
67MP0005075_abnormal_melanosome_morpholog1.52844306
68MP0003984_embryonic_growth_retardation1.50940955
69MP0002086_abnormal_extraembryonic_tissu1.50912866
70MP0001529_abnormal_vocalization1.48576131
71MP0002160_abnormal_reproductive_system1.48043015
72MP0001697_abnormal_embryo_size1.47294088
73MP0002088_abnormal_embryonic_growth/wei1.46372944
74MP0006292_abnormal_olfactory_placode1.45491980
75MP0001501_abnormal_sleep_pattern1.42398427
76MP0002234_abnormal_pharynx_morphology1.42278557
77MP0002254_reproductive_system_inflammat1.40911925
78MP0005379_endocrine/exocrine_gland_phen1.38721846
79MP0004233_abnormal_muscle_weight1.38204924
80MP0001764_abnormal_homeostasis1.37966859
81MP0003119_abnormal_digestive_system1.35671747
82MP0005076_abnormal_cell_differentiation1.35566993
83MP0004264_abnormal_extraembryonic_tissu1.34698629
84MP0002272_abnormal_nervous_system1.33358787
85MP0005084_abnormal_gallbladder_morpholo1.31513414
86MP0002396_abnormal_hematopoietic_system1.30722358
87MP0002138_abnormal_hepatobiliary_system1.29580720
88MP0003136_yellow_coat_color1.28946574
89MP0001293_anophthalmia1.28323517
90MP0003941_abnormal_skin_development1.28313358
91MP0001486_abnormal_startle_reflex1.28247099
92MP0009053_abnormal_anal_canal1.26829442
93MP0002080_prenatal_lethality1.26613750
94MP0005266_abnormal_metabolism1.26119488
95MP0004142_abnormal_muscle_tone1.24971194
96MP0006276_abnormal_autonomic_nervous1.20665993
97MP0005174_abnormal_tail_pigmentation1.19903258
98MP0003121_genomic_imprinting1.16944076
99MP0001905_abnormal_dopamine_level1.15440981
100MP0002064_seizures1.13621080
101MP0002557_abnormal_social/conspecific_i1.12989466
102MP0002095_abnormal_skin_pigmentation1.12061292
103MP0002572_abnormal_emotion/affect_behav1.10964587
104MP0001849_ear_inflammation1.10325934
105MP0002928_abnormal_bile_duct1.08876689
106MP0001970_abnormal_pain_threshold1.08292269
107MP0002733_abnormal_thermal_nociception1.06970025
108MP0000313_abnormal_cell_death1.06610912
109MP0000678_abnormal_parathyroid_gland1.06471138
110MP0003283_abnormal_digestive_organ1.05655188
111MP0002735_abnormal_chemical_nociception1.05211524
112MP0000383_abnormal_hair_follicle1.02791384
113MP0002638_abnormal_pupillary_reflex1.02454418
114MP0004924_abnormal_behavior1.01986086
115MP0005386_behavior/neurological_phenoty1.01986086
116MP0005332_abnormal_amino_acid1.01816456
117MP0002277_abnormal_respiratory_mucosa1.01806249
118MP0002249_abnormal_larynx_morphology1.00711644
119MP0005389_reproductive_system_phenotype0.98156177
120MP0000015_abnormal_ear_pigmentation0.97662470
121MP0002909_abnormal_adrenal_gland0.94007923
122MP0001485_abnormal_pinna_reflex0.94003877
123MP0004742_abnormal_vestibular_system0.93073788
124MP0005195_abnormal_posterior_eye0.92445222
125MP0008995_early_reproductive_senescence0.92187827
126MP0003718_maternal_effect0.91997705
127MP0006036_abnormal_mitochondrial_physio0.91822865
128MP0005623_abnormal_meninges_morphology0.91281984
129MP0004885_abnormal_endolymph0.90440556
130MP0002233_abnormal_nose_morphology0.89640184
131MP0009672_abnormal_birth_weight0.89596465
132MP0001324_abnormal_eye_pigmentation0.89233867
133MP0005367_renal/urinary_system_phenotyp0.88974575
134MP0000516_abnormal_urinary_system0.88974575
135MP0002019_abnormal_tumor_incidence0.88621469
136MP0002332_abnormal_exercise_endurance0.88150730
137MP0005023_abnormal_wound_healing0.88075973
138MP0002067_abnormal_sensory_capabilities0.87430056
139MP0005670_abnormal_white_adipose0.86118960
140MP0001919_abnormal_reproductive_system0.85900203
141MP0003937_abnormal_limbs/digits/tail_de0.85626834
142MP0002751_abnormal_autonomic_nervous0.85514601
143MP0009703_decreased_birth_body0.83380022
144MP0003938_abnormal_ear_development0.82930293
145MP0004215_abnormal_myocardial_fiber0.82091304
146MP0000762_abnormal_tongue_morphology0.81454653
147MP0003011_delayed_dark_adaptation0.81295525
148MP0008775_abnormal_heart_ventricle0.80614907
149MP0002693_abnormal_pancreas_physiology0.80103918
150MP0000432_abnormal_head_morphology0.79989275
151MP0002063_abnormal_learning/memory/cond0.79602870
152MP0010329_abnormal_lipoprotein_level0.79321979
153MP0002229_neurodegeneration0.79018927
154MP0002090_abnormal_vision0.78907546
155MP0005220_abnormal_exocrine_pancreas0.78844389
156MP0002734_abnormal_mechanical_nocicepti0.78193814
157MP0010386_abnormal_urinary_bladder0.77823997
158MP0002111_abnormal_tail_morphology0.76109471
159MP0002269_muscular_atrophy0.72746055
160MP0003936_abnormal_reproductive_system0.71852173
161MP0003861_abnormal_nervous_system0.68192621
162MP0001119_abnormal_female_reproductive0.68033733
163MP0002114_abnormal_axial_skeleton0.67851484
164MP0003755_abnormal_palate_morphology0.67577650
165MP0001915_intracranial_hemorrhage0.67083317
166MP0003186_abnormal_redox_activity0.65777584
167MP0003315_abnormal_perineum_morphology0.65308231
168MP0002127_abnormal_cardiovascular_syste0.65260656
169MP0003385_abnormal_body_wall0.64445906
170MP0002092_abnormal_eye_morphology0.63710099
171MP0000537_abnormal_urethra_morphology0.62625984
172MP0005397_hematopoietic_system_phenotyp0.60898749
173MP0001545_abnormal_hematopoietic_system0.60898749
174MP0000534_abnormal_ureter_morphology0.60481605
175MP0002932_abnormal_joint_morphology0.59963953
176MP0004134_abnormal_chest_morphology0.59830719
177MP0002925_abnormal_cardiovascular_devel0.58648171
178MP0002697_abnormal_eye_size0.58434370
179MP0003699_abnormal_female_reproductive0.58172411

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.40019079
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.12698197
3Absent/shortened dynein arms (HP:0200106)6.12698197
4Ependymoma (HP:0002888)4.79110450
5Pancreatic cysts (HP:0001737)4.39925873
6Abnormal respiratory motile cilium physiology (HP:0012261)4.35122311
7Abnormal respiratory epithelium morphology (HP:0012253)4.32030586
8Abnormal respiratory motile cilium morphology (HP:0005938)4.32030586
9Pancreatic fibrosis (HP:0100732)4.16725578
10Chronic bronchitis (HP:0004469)3.94108695
11True hermaphroditism (HP:0010459)3.86544941
12Abnormality of midbrain morphology (HP:0002418)3.85021972
13Molar tooth sign on MRI (HP:0002419)3.85021972
14Congenital stationary night blindness (HP:0007642)3.80082193
15Astrocytoma (HP:0009592)3.69089054
16Abnormality of the astrocytes (HP:0100707)3.69089054
17Abnormal ciliary motility (HP:0012262)3.58238338
18Neoplasm of the oral cavity (HP:0100649)3.54517089
19Nephronophthisis (HP:0000090)3.46882061
20Aplasia/hypoplasia of the humerus (HP:0006507)3.44866547
21Abnormality of the lower motor neuron (HP:0002366)3.43626925
22Short humerus (HP:0005792)3.39951084
23Glioma (HP:0009733)3.32120961
24Abnormality of the labia minora (HP:0012880)3.29990990
25Medulloblastoma (HP:0002885)3.28838036
26Chromsome breakage (HP:0040012)3.28253667
27Supernumerary spleens (HP:0009799)3.27344161
28Selective tooth agenesis (HP:0001592)3.27268564
29Rhabdomyosarcoma (HP:0002859)3.23331699
30Abnormality of abdominal situs (HP:0011620)3.17232227
31Abdominal situs inversus (HP:0003363)3.17232227
32Rhinitis (HP:0012384)3.14781439
33Abnormality of the renal cortex (HP:0011035)3.13713007
34Chromosomal breakage induced by crosslinking agents (HP:0003221)3.11734123
35Pendular nystagmus (HP:0012043)3.02388493
36Abnormality of the renal medulla (HP:0100957)2.98172864
37Type II lissencephaly (HP:0007260)2.93848572
38Attenuation of retinal blood vessels (HP:0007843)2.91160625
39Rib fusion (HP:0000902)2.90775424
40Medial flaring of the eyebrow (HP:0010747)2.88512860
41Abolished electroretinogram (ERG) (HP:0000550)2.82828764
42Neoplasm of striated muscle (HP:0009728)2.81525077
43Missing ribs (HP:0000921)2.78296474
44Abnormal rod and cone electroretinograms (HP:0008323)2.72618930
45Polydipsia (HP:0001959)2.71186968
46Abnormal drinking behavior (HP:0030082)2.71186968
47Tubular atrophy (HP:0000092)2.71082346
48Impulsivity (HP:0100710)2.70271526
49Hyperventilation (HP:0002883)2.69353909
50Agnosia (HP:0010524)2.67500228
51Abnormality of the salivary glands (HP:0010286)2.66886358
52Chronic hepatic failure (HP:0100626)2.64945017
53Cystic liver disease (HP:0006706)2.61062308
54Nephroblastoma (Wilms tumor) (HP:0002667)2.59536290
55Hypochromic microcytic anemia (HP:0004840)2.54844072
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54014875
57Abnormality of alanine metabolism (HP:0010916)2.54014875
58Hyperalaninemia (HP:0003348)2.54014875
59Shawl scrotum (HP:0000049)2.53033404
60Decreased central vision (HP:0007663)2.47638852
61Methylmalonic acidemia (HP:0002912)2.47009290
62Inability to walk (HP:0002540)2.45278086
63Ketoacidosis (HP:0001993)2.41424300
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.39788055
65Embryonal renal neoplasm (HP:0011794)2.37204720
66Absent radius (HP:0003974)2.36648058
67Gait imbalance (HP:0002141)2.35526860
6811 pairs of ribs (HP:0000878)2.35222709
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.34988616
70Nasal polyposis (HP:0100582)2.34143262
71Breast hypoplasia (HP:0003187)2.33948551
72Abnormality of chromosome stability (HP:0003220)2.33076550
73Meckel diverticulum (HP:0002245)2.32902869
74Colon cancer (HP:0003003)2.32630441
75Congenital primary aphakia (HP:0007707)2.32165924
76Stenosis of the external auditory canal (HP:0000402)2.32164048
77Progressive inability to walk (HP:0002505)2.31605054
78Renal cortical cysts (HP:0000803)2.30617675
79Multiple enchondromatosis (HP:0005701)2.30246121
80Abnormality of the renal collecting system (HP:0004742)2.29223341
81Abnormal biliary tract physiology (HP:0012439)2.27744433
82Bile duct proliferation (HP:0001408)2.27744433
83Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.27571659
84Short 1st metacarpal (HP:0010034)2.27571659
85Abnormality of the ileum (HP:0001549)2.25873913
86Infertility (HP:0000789)2.24916214
87High anterior hairline (HP:0009890)2.24840944
88Increased corneal curvature (HP:0100692)2.23674967
89Keratoconus (HP:0000563)2.23674967
90Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22699825
91Hypothermia (HP:0002045)2.22394417
92Abnormal lung lobation (HP:0002101)2.21973086
93Polyuria (HP:0000103)2.21121695
94Sclerocornea (HP:0000647)2.20924544
95Acute necrotizing encephalopathy (HP:0006965)2.20069020
96Mitochondrial inheritance (HP:0001427)2.19548635
97Absent forearm bone (HP:0003953)2.19298085
98Aplasia involving forearm bones (HP:0009822)2.19298085
99Increased CSF lactate (HP:0002490)2.18887914
100Furrowed tongue (HP:0000221)2.16930835
101Volvulus (HP:0002580)2.16709133
102Anencephaly (HP:0002323)2.15291702
103Cerebellar dysplasia (HP:0007033)2.14863389
104Progressive macrocephaly (HP:0004481)2.14287016
105Acute encephalopathy (HP:0006846)2.13270543
106Ketosis (HP:0001946)2.13243881
107Nephrogenic diabetes insipidus (HP:0009806)2.12918834
108Postaxial foot polydactyly (HP:0001830)2.11751575
109Gaze-evoked nystagmus (HP:0000640)2.10326579
110Gonadotropin excess (HP:0000837)2.09805081
111Genital tract atresia (HP:0001827)2.09516650
112Increased nuchal translucency (HP:0010880)2.09384374
113Birth length less than 3rd percentile (HP:0003561)2.08609831
114Abnormality of the preputium (HP:0100587)2.08017904
115Methylmalonic aciduria (HP:0012120)2.07552275
1163-Methylglutaconic aciduria (HP:0003535)2.07369188
117Aplasia/Hypoplasia of the patella (HP:0006498)2.06429453
118Aplasia/Hypoplasia of the tibia (HP:0005772)2.06191488
119Absent thumb (HP:0009777)2.06189315
120Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05054435
121Lip pit (HP:0100267)2.04531171
122Large for gestational age (HP:0001520)2.02852420
123Supernumerary ribs (HP:0005815)2.01817460
124Small intestinal stenosis (HP:0012848)2.00938229
125Duodenal stenosis (HP:0100867)2.00938229
126Congenital hepatic fibrosis (HP:0002612)2.00527918
127Lissencephaly (HP:0001339)1.99322159
128Decreased circulating renin level (HP:0003351)1.98920861
129Abnormality of the pons (HP:0007361)1.98839460
130Thyroiditis (HP:0100646)1.98136744
131Hyperglycinuria (HP:0003108)1.98066498
132Hepatic necrosis (HP:0002605)1.97606361
133Facial hemangioma (HP:0000329)1.96393013
134Hypoplasia of the fovea (HP:0007750)1.95582016
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.95582016
136Male pseudohermaphroditism (HP:0000037)1.94419437
137Hepatocellular necrosis (HP:0001404)1.94059720
138Abnormality of cochlea (HP:0000375)1.93746741
139Sloping forehead (HP:0000340)1.93637343
140Abnormality of the 1st metacarpal (HP:0010009)1.92356322
141Supernumerary bones of the axial skeleton (HP:0009144)1.91883637
142Hyperglycinemia (HP:0002154)1.91518100
143Intestinal atresia (HP:0011100)1.90945093
144Vaginal atresia (HP:0000148)1.89043880
145Abnormality of macular pigmentation (HP:0008002)1.88676832
146Esophageal atresia (HP:0002032)1.87022074
147Bilateral microphthalmos (HP:0007633)1.86705496
148Abnormality of vitamin B metabolism (HP:0004340)1.86002418
149Heterotopia (HP:0002282)1.85744228
150Optic nerve hypoplasia (HP:0000609)1.84760257
151Hypoproteinemia (HP:0003075)1.84151813
152Short phalanx of the thumb (HP:0009660)1.83977984
153Patellar aplasia (HP:0006443)1.83908721
154Congenital sensorineural hearing impairment (HP:0008527)1.83742598
155Basal cell carcinoma (HP:0002671)1.83127741
156Optic disc pallor (HP:0000543)1.82472482
157Hemiparesis (HP:0001269)1.81933012
158Hypomagnesemia (HP:0002917)1.81922593
159Abnormality of the anterior horn cell (HP:0006802)1.81839991
160Degeneration of anterior horn cells (HP:0002398)1.81839991
161Concave nail (HP:0001598)1.81155257
162Stomach cancer (HP:0012126)1.80041275
163Pseudobulbar signs (HP:0002200)1.79743682
164Severe visual impairment (HP:0001141)1.79714476
165Myelodysplasia (HP:0002863)1.79423510
166Febrile seizures (HP:0002373)1.78197786
167Upper motor neuron abnormality (HP:0002127)1.77917409
168Abnormality of the fovea (HP:0000493)1.77899996
169Lipid accumulation in hepatocytes (HP:0006561)1.77158076
170Abnormality of serine family amino acid metabolism (HP:0010894)1.76893720
171Abnormality of glycine metabolism (HP:0010895)1.76893720
172Vertebral fusion (HP:0002948)1.76442777
173Hypoplasia of the pons (HP:0012110)1.76429079
174Abnormal urine output (HP:0012590)1.76235079
175Abnormality of the nasal mucosa (HP:0000433)1.75812982
176Occipital encephalocele (HP:0002085)1.75705156
177Abnormal mitochondria in muscle tissue (HP:0008316)1.74891161
178Hypoplasia of the radius (HP:0002984)1.74705251
179Postaxial hand polydactyly (HP:0001162)1.74628670
180Astigmatism (HP:0000483)1.74342668
181Pachygyria (HP:0001302)1.74286392
182Biliary tract neoplasm (HP:0100574)1.74224793
183Carpal bone hypoplasia (HP:0001498)1.73739276
184Hypopigmentation of the fundus (HP:0007894)1.72231015
185Aplasia/Hypoplasia of the sternum (HP:0006714)1.72171758
186Urethral obstruction (HP:0000796)1.72164906
187Proximal placement of thumb (HP:0009623)1.71243074
188Ectopic kidney (HP:0000086)1.71007217
189Atresia of the external auditory canal (HP:0000413)1.69522874
190Metaphyseal cupping (HP:0003021)1.68596786
191Prominent nose (HP:0000448)1.68108985
192Abnormality of the duodenum (HP:0002246)1.67856828
193Duplicated collecting system (HP:0000081)1.67400336
194Vertebral clefting (HP:0008428)1.67206188
195Fibular hypoplasia (HP:0003038)1.66420205
196Facial cleft (HP:0002006)1.66278501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.26709265
2FRK5.91518892
3PDK35.58559569
4PDK45.58559569
5PDK23.72862632
6TTK3.36276564
7WEE13.25958977
8MAP4K23.22140686
9CDC73.12674224
10ADRBK23.03526081
11WNK32.98713883
12PINK12.66189959
13BMPR1B2.48393261
14BRD42.47760057
15NUAK12.30600977
16PNCK2.27059686
17GRK12.25492305
18NEK22.21902039
19RPS6KB22.18748832
20INSRR2.14276766
21TAOK32.13767472
22TRIM282.04273642
23BUB12.03007868
24PLK11.90339073
25EPHA21.78542869
26MAPK131.67040256
27NEK11.65958235
28ICK1.61897845
29CHEK21.57453568
30CASK1.56102756
31MAP3K41.51874974
32ATR1.51712061
33CDK71.50725187
34WNK41.49878685
35DAPK21.49030202
36PAK31.45489312
37TNIK1.44907160
38TSSK61.41496747
39AKT31.40692439
40STK101.38875275
41CHEK11.38724280
42ERBB31.37292719
43OXSR11.33634386
44PASK1.33569649
45BCR1.28812636
46TESK11.23751444
47ZAK1.20614457
48TLK11.19364321
49STK391.16141174
50VRK21.15935324
51PLK31.15540276
52FGFR21.12988946
53ATM1.11309126
54TYRO31.11079450
55STK161.09611595
56MAPKAPK31.07805673
57PRKCE1.05803495
58AURKA1.03786533
59BRSK21.02419644
60PAK41.00774941
61AURKB1.00342579
62TXK1.00098172
63DYRK20.99858695
64PLK20.98708118
65MARK10.97608232
66PTK2B0.95878764
67TESK20.95132959
68CDK20.92932577
69MAP2K70.91595275
70CSNK1G10.90087005
71MATK0.90072566
72MTOR0.89138755
73PHKG10.88946322
74PHKG20.88946322
75ADRBK10.87973253
76ALK0.86886198
77FER0.85197049
78CDK40.83298044
79CSNK1G20.83100017
80CAMKK20.81907429
81MET0.81898860
82STK40.81212133
83MAP3K80.80269211
84CDK60.79955771
85PRKCI0.79275531
86TNK20.79049876
87CSNK1G30.77660638
88MST40.76266201
89SRPK10.75342973
90EIF2AK10.75255739
91DYRK30.72968634
92NTRK30.72493829
93PRKCG0.71787189
94PLK40.70989942
95EPHA40.70556364
96EEF2K0.69085769
97CDK10.68376379
98IRAK10.66916389
99IKBKB0.65401304
100PIM10.63329685
101CSNK1E0.62250698
102CSNK1A1L0.61814948
103CAMK1D0.60270890
104MAPKAPK50.58749456
105CSNK2A20.58569085
106CSNK1D0.58562803
107TIE10.58220833
108LATS20.57807017
109SCYL20.55837544
110PRKCQ0.55030549
111TGFBR10.51510420
112CSNK1A10.51355442
113VRK10.51035226
114WNK10.48947848
115CAMK2A0.48001594
116MAP3K120.47885884
117MUSK0.47146655
118BCKDK0.47019018
119RPS6KA50.46408821
120TAF10.46349211
121PRKCZ0.46295311
122ACVR1B0.45783246
123PAK10.45378923
124TEC0.44626681
125PRKDC0.44126705
126EIF2AK30.42945715
127MAP3K100.42698130
128PIK3CA0.42107560
129PKN10.41236965
130STK380.41178031
131MKNK10.40838167
132MKNK20.40828104
133MAP2K60.39443718
134MAPK70.39415850
135MELK0.39332603
136CSNK2A10.38582656
137FLT30.38290501
138PRKACA0.38059806
139DDR20.38033896
140NLK0.37889753
141STK38L0.37502753
142MAPK140.37424456
143CLK10.36881528
144MAPK10.36822500
145MAP3K30.36818638
146EIF2AK20.36611863
147GSK3B0.36596113
148IGF1R0.35119481
149BMX0.34430750
150CAMK10.34172335
151ABL10.33690219
152BLK0.31860539
153PRKAA20.31306474
154STK110.31085399
155MAPK100.31012767
156PBK0.30177196
157RPS6KA40.28968433
158BRSK10.28152147
159PRKCA0.28026117
160DAPK10.27511571
161RPS6KB10.27228012
162STK30.25074702
163CSF1R0.23231399
164PRKD30.22186330
165AKT20.21993921
166YES10.21792170
167BRAF0.19835056
168TAOK20.19093124
169CDK90.18947918
170CAMK1G0.18787528
171DYRK1B0.17674937
172AKT10.17387329
173CSK0.17353329
174CDC42BPA0.16673616
175RPS6KA10.16625030

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.34337834
2DNA replication_Homo sapiens_hsa030304.29994243
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.94199888
4RNA transport_Homo sapiens_hsa030133.17879068
5Homologous recombination_Homo sapiens_hsa034402.90521624
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84463420
7Fanconi anemia pathway_Homo sapiens_hsa034602.83598443
8One carbon pool by folate_Homo sapiens_hsa006702.80796823
9Phototransduction_Homo sapiens_hsa047442.68721960
10Spliceosome_Homo sapiens_hsa030402.60422699
11Vitamin B6 metabolism_Homo sapiens_hsa007502.60072347
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59833973
13Base excision repair_Homo sapiens_hsa034102.52090512
14Nucleotide excision repair_Homo sapiens_hsa034202.51796721
15Cell cycle_Homo sapiens_hsa041102.47071441
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.45799437
17Butanoate metabolism_Homo sapiens_hsa006502.43702118
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.41181429
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36212470
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22377114
21Non-homologous end-joining_Homo sapiens_hsa034502.18069161
22Basal transcription factors_Homo sapiens_hsa030222.14652579
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09630773
24Protein export_Homo sapiens_hsa030602.01089290
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.99311979
26Oxidative phosphorylation_Homo sapiens_hsa001901.97403257
27Caffeine metabolism_Homo sapiens_hsa002321.95842617
28mRNA surveillance pathway_Homo sapiens_hsa030151.92273367
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87039175
30RNA polymerase_Homo sapiens_hsa030201.82537076
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75588109
32Ether lipid metabolism_Homo sapiens_hsa005651.73534018
33Pyrimidine metabolism_Homo sapiens_hsa002401.73266269
34Biosynthesis of amino acids_Homo sapiens_hsa012301.71149775
35Tryptophan metabolism_Homo sapiens_hsa003801.70544192
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69204042
37Ribosome_Homo sapiens_hsa030101.60249164
38RNA degradation_Homo sapiens_hsa030181.60144351
39Glutathione metabolism_Homo sapiens_hsa004801.59634282
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54581562
41Oocyte meiosis_Homo sapiens_hsa041141.54278723
42Parkinsons disease_Homo sapiens_hsa050121.48588429
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.48059779
44Selenocompound metabolism_Homo sapiens_hsa004501.45967739
45Pentose phosphate pathway_Homo sapiens_hsa000301.44670624
46Nicotine addiction_Homo sapiens_hsa050331.43191217
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43100690
48p53 signaling pathway_Homo sapiens_hsa041151.41690816
49Pyruvate metabolism_Homo sapiens_hsa006201.35240621
50Regulation of autophagy_Homo sapiens_hsa041401.28805919
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.19718752
52Chemical carcinogenesis_Homo sapiens_hsa052041.17489351
53Sulfur metabolism_Homo sapiens_hsa009201.16737104
54Peroxisome_Homo sapiens_hsa041461.16403483
55Carbon metabolism_Homo sapiens_hsa012001.14152890
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11432558
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11067911
58Taste transduction_Homo sapiens_hsa047421.09697914
59Fructose and mannose metabolism_Homo sapiens_hsa000511.09377855
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09223633
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04294614
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04073845
63Purine metabolism_Homo sapiens_hsa002301.00954131
64Fatty acid elongation_Homo sapiens_hsa000620.99588213
65Propanoate metabolism_Homo sapiens_hsa006400.97851416
66Morphine addiction_Homo sapiens_hsa050320.97354961
67Olfactory transduction_Homo sapiens_hsa047400.94998428
68Proteasome_Homo sapiens_hsa030500.94668678
69Systemic lupus erythematosus_Homo sapiens_hsa053220.94350112
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90471892
71Collecting duct acid secretion_Homo sapiens_hsa049660.90389463
72Insulin secretion_Homo sapiens_hsa049110.88771087
73Folate biosynthesis_Homo sapiens_hsa007900.88460092
74ABC transporters_Homo sapiens_hsa020100.87566325
75Linoleic acid metabolism_Homo sapiens_hsa005910.85461105
76Fatty acid biosynthesis_Homo sapiens_hsa000610.84134497
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.83296725
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82940652
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79281504
80Viral carcinogenesis_Homo sapiens_hsa052030.78991818
81Serotonergic synapse_Homo sapiens_hsa047260.78531778
82GABAergic synapse_Homo sapiens_hsa047270.78473591
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77976610
84Glucagon signaling pathway_Homo sapiens_hsa049220.77520000
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77258357
86Lysine degradation_Homo sapiens_hsa003100.76101026
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75900907
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74985946
89beta-Alanine metabolism_Homo sapiens_hsa004100.74956385
90Alzheimers disease_Homo sapiens_hsa050100.73214801
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72675867
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72079887
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71616947
94Mineral absorption_Homo sapiens_hsa049780.71085117
95Epstein-Barr virus infection_Homo sapiens_hsa051690.69418275
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.69145177
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.67774650
98Hippo signaling pathway_Homo sapiens_hsa043900.66573183
99Ovarian steroidogenesis_Homo sapiens_hsa049130.65747918
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65678083
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64391250
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64118673
103Basal cell carcinoma_Homo sapiens_hsa052170.63653980
104HTLV-I infection_Homo sapiens_hsa051660.62595343
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.62296108
106Steroid biosynthesis_Homo sapiens_hsa001000.61555233
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61038709
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60478953
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60088978
110Type I diabetes mellitus_Homo sapiens_hsa049400.59633905
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58057678
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56472017
113Adherens junction_Homo sapiens_hsa045200.55803452
114Circadian entrainment_Homo sapiens_hsa047130.54904001
115Primary immunodeficiency_Homo sapiens_hsa053400.49100075
116Vitamin digestion and absorption_Homo sapiens_hsa049770.48857008
117Histidine metabolism_Homo sapiens_hsa003400.48799254
118MicroRNAs in cancer_Homo sapiens_hsa052060.48116331
119Asthma_Homo sapiens_hsa053100.48030891
120Cardiac muscle contraction_Homo sapiens_hsa042600.47346492
121mTOR signaling pathway_Homo sapiens_hsa041500.46805960
122Fatty acid degradation_Homo sapiens_hsa000710.46454715
123Glutamatergic synapse_Homo sapiens_hsa047240.46222366
124Herpes simplex infection_Homo sapiens_hsa051680.45970793
125Hedgehog signaling pathway_Homo sapiens_hsa043400.45956989
126Tight junction_Homo sapiens_hsa045300.45718885
127Thyroid cancer_Homo sapiens_hsa052160.45714321
128Glycerolipid metabolism_Homo sapiens_hsa005610.44894189
129Galactose metabolism_Homo sapiens_hsa000520.44021503
130Calcium signaling pathway_Homo sapiens_hsa040200.43756225
131TGF-beta signaling pathway_Homo sapiens_hsa043500.43511289
132Salivary secretion_Homo sapiens_hsa049700.43253378
133Fatty acid metabolism_Homo sapiens_hsa012120.42712113
134Retinol metabolism_Homo sapiens_hsa008300.42372537
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40762271
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39629089
137Steroid hormone biosynthesis_Homo sapiens_hsa001400.39503288
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.38697604
139Notch signaling pathway_Homo sapiens_hsa043300.37446808
140Antigen processing and presentation_Homo sapiens_hsa046120.37154664
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36397742
142Dorso-ventral axis formation_Homo sapiens_hsa043200.34552872
143Wnt signaling pathway_Homo sapiens_hsa043100.28825327
144HIF-1 signaling pathway_Homo sapiens_hsa040660.28274786
145Prion diseases_Homo sapiens_hsa050200.27820865
146Fat digestion and absorption_Homo sapiens_hsa049750.26034352
147Small cell lung cancer_Homo sapiens_hsa052220.25031700
148Pathways in cancer_Homo sapiens_hsa052000.23268842
149Legionellosis_Homo sapiens_hsa051340.22791065
150Metabolic pathways_Homo sapiens_hsa011000.22687780
151Huntingtons disease_Homo sapiens_hsa050160.21643487
152Alcoholism_Homo sapiens_hsa050340.20146290
153Nitrogen metabolism_Homo sapiens_hsa009100.19475599
154Prostate cancer_Homo sapiens_hsa052150.17418540
155Protein digestion and absorption_Homo sapiens_hsa049740.14825928
156Sulfur relay system_Homo sapiens_hsa041220.14020158
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13422336
158Arginine and proline metabolism_Homo sapiens_hsa003300.12754369
159Arachidonic acid metabolism_Homo sapiens_hsa005900.11537164
160Inositol phosphate metabolism_Homo sapiens_hsa005620.09276429

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