OTUB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)4.93176184
2proteasome assembly (GO:0043248)4.91733260
3negative regulation of dendrite morphogenesis (GO:0050774)4.76514495
4DNA deamination (GO:0045006)4.74413825
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.70245343
6neuron cell-cell adhesion (GO:0007158)4.64349815
7regulation of cellular amino acid metabolic process (GO:0006521)4.54330285
8synaptic vesicle exocytosis (GO:0016079)4.49580038
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.43008716
10vocalization behavior (GO:0071625)4.36898275
11DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.35557478
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.33728040
13negative regulation of ligase activity (GO:0051352)4.33728040
14termination of RNA polymerase III transcription (GO:0006386)4.30389356
15transcription elongation from RNA polymerase III promoter (GO:0006385)4.30389356
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.26959335
17presynaptic membrane assembly (GO:0097105)4.23574240
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.20727218
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.20727218
20signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.20727218
21intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.20609943
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.20609943
23neuronal action potential propagation (GO:0019227)4.18116999
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17297065
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.15848794
26respiratory chain complex IV assembly (GO:0008535)4.10891332
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08901714
28signal transduction involved in DNA integrity checkpoint (GO:0072401)4.05753377
29signal transduction involved in DNA damage checkpoint (GO:0072422)4.05753377
30protein localization to synapse (GO:0035418)4.03718608
31signal transduction involved in cell cycle checkpoint (GO:0072395)4.01075432
32cytochrome complex assembly (GO:0017004)3.97147321
33regulation of mitochondrial translation (GO:0070129)3.95060024
34regulation of synaptic vesicle exocytosis (GO:2000300)3.93467745
35ATP hydrolysis coupled proton transport (GO:0015991)3.91481749
36energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.91481749
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.90271162
38presynaptic membrane organization (GO:0097090)3.89220317
39protein neddylation (GO:0045116)3.89066822
40transferrin transport (GO:0033572)3.87667670
41postsynaptic membrane organization (GO:0001941)3.87572015
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84168800
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.82270283
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79573147
45regulation of glutamate receptor signaling pathway (GO:1900449)3.74296238
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.74184071
47glutamate secretion (GO:0014047)3.67513406
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.65133748
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.63504326
50regulation of short-term neuronal synaptic plasticity (GO:0048172)3.62637514
51metallo-sulfur cluster assembly (GO:0031163)3.61436839
52iron-sulfur cluster assembly (GO:0016226)3.61436839
53rRNA modification (GO:0000154)3.58430248
54cullin deneddylation (GO:0010388)3.58249679
55peptidyl-histidine modification (GO:0018202)3.55745475
56trivalent inorganic cation transport (GO:0072512)3.55688212
57ferric iron transport (GO:0015682)3.55688212
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55640630
59ATP synthesis coupled proton transport (GO:0015986)3.55640630
60negative regulation of dendrite development (GO:2000171)3.55567215
61spliceosomal snRNP assembly (GO:0000387)3.55353850
62regulation of cellular amine metabolic process (GO:0033238)3.55294820
63neuron-neuron synaptic transmission (GO:0007270)3.53949980
64regulation of synaptic vesicle transport (GO:1902803)3.53589178
65protein targeting to mitochondrion (GO:0006626)3.52113442
66pseudouridine synthesis (GO:0001522)3.50694412
67positive regulation of mitochondrial fission (GO:0090141)3.50279769
68positive regulation of ligase activity (GO:0051351)3.48468758
69regulation of glutamate secretion (GO:0014048)3.45519891
70establishment of protein localization to mitochondrion (GO:0072655)3.45081774
71startle response (GO:0001964)3.44130350
72GDP-mannose metabolic process (GO:0019673)3.43176059
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42819300
74neurotransmitter-gated ion channel clustering (GO:0072578)3.42650530
75ATP biosynthetic process (GO:0006754)3.41339394
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.39320287
77hydrogen ion transmembrane transport (GO:1902600)3.38745938
78DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.37810933
79synaptic transmission, glutamatergic (GO:0035249)3.36600074
80purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36410405
81inositol phosphate catabolic process (GO:0071545)3.36204345
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.35664969
83maturation of 5.8S rRNA (GO:0000460)3.33828725
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.33430201
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32932026
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32932026
87protein complex biogenesis (GO:0070271)3.31825090
88positive regulation of synapse assembly (GO:0051965)3.30098523
89ribosomal small subunit assembly (GO:0000028)3.27854325
90protein deneddylation (GO:0000338)3.25988806
91positive regulation of cell cycle arrest (GO:0071158)3.25705502
92neurotransmitter secretion (GO:0007269)3.25089250
93base-excision repair, AP site formation (GO:0006285)3.24663184
94establishment of viral latency (GO:0019043)3.23831774
95regulation of ubiquitin-protein transferase activity (GO:0051438)3.23005473
96ionotropic glutamate receptor signaling pathway (GO:0035235)3.22191905
97gamma-aminobutyric acid signaling pathway (GO:0007214)3.20545782
98protein localization to mitochondrion (GO:0070585)3.18947447
99GTP biosynthetic process (GO:0006183)3.17695954
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13505757
101mannosylation (GO:0097502)3.10991713
102regulation of ligase activity (GO:0051340)3.10801055
103glutamate receptor signaling pathway (GO:0007215)3.09224174
104positive regulation of neurotransmitter transport (GO:0051590)3.08397353
105ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06738265
106serotonin receptor signaling pathway (GO:0007210)3.05410773
107membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05099321
108proton transport (GO:0015992)3.04936416
109purine deoxyribonucleotide catabolic process (GO:0009155)3.03024230
110respiratory electron transport chain (GO:0022904)3.02374553
111long-term synaptic potentiation (GO:0060291)3.02262472
112nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02215978
113transmission of nerve impulse (GO:0019226)3.02048927
114* negative regulation of protein ubiquitination (GO:0031397)3.00767653
115DNA damage response, detection of DNA damage (GO:0042769)3.00460073
116establishment of integrated proviral latency (GO:0075713)2.99404461
117hydrogen transport (GO:0006818)2.98228477
118regulation of protein kinase A signaling (GO:0010738)2.97013918
119guanosine-containing compound biosynthetic process (GO:1901070)2.96761746
120neurofilament cytoskeleton organization (GO:0060052)2.96609593
121electron transport chain (GO:0022900)2.96402422
122female mating behavior (GO:0060180)2.96352085
123regulation of excitatory postsynaptic membrane potential (GO:0060079)2.95328232
124positive regulation of neurotransmitter secretion (GO:0001956)2.93967948
125phagosome maturation (GO:0090382)2.93049905
126GMP metabolic process (GO:0046037)2.92785862
127aldehyde catabolic process (GO:0046185)2.92055874
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.90786744
129NADH dehydrogenase complex assembly (GO:0010257)2.90786744
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.90786744
131intracellular protein transmembrane import (GO:0044743)2.90434538
132protein localization to cilium (GO:0061512)2.90320145
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90061735
134neurotransmitter uptake (GO:0001504)2.89995554
135regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89737250
136regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89737250
137regulation of cell cycle arrest (GO:0071156)2.89119662
138signal transduction in response to DNA damage (GO:0042770)2.88614006
139mitochondrial respiratory chain complex assembly (GO:0033108)2.88590806
140UTP biosynthetic process (GO:0006228)2.87936909
141behavioral response to nicotine (GO:0035095)2.87532879
142regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87423213
143striatum development (GO:0021756)2.87146659
144dopamine transport (GO:0015872)2.86877617
145* negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.86463604
146translation (GO:0006412)2.85948628
147regulation of neuronal synaptic plasticity (GO:0048168)2.85919859
148nuclear envelope reassembly (GO:0031468)2.85907213
149mitotic nuclear envelope reassembly (GO:0007084)2.85907213
150pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84826703
151positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84268408
152deoxyribonucleotide catabolic process (GO:0009264)2.84089725
153positive regulation of amino acid transport (GO:0051957)2.83955923
154oxidative phosphorylation (GO:0006119)2.82947649
155opioid receptor signaling pathway (GO:0038003)2.81181617
156regulation of neurotransmitter secretion (GO:0046928)2.80951062
157negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80943435
158neuron recognition (GO:0008038)2.80908521
159cellular component biogenesis (GO:0044085)2.80772217
160protein maturation by protein folding (GO:0022417)2.80726782
161water-soluble vitamin biosynthetic process (GO:0042364)2.80645386
162regulation of postsynaptic membrane potential (GO:0060078)2.80545762
163dendrite development (GO:0016358)2.80033949
164positive regulation of cellular response to oxidative stress (GO:1900409)2.79678108
165positive regulation of response to oxidative stress (GO:1902884)2.79678108
166cell migration in hindbrain (GO:0021535)2.79663370
167response to histamine (GO:0034776)2.76581087
168regulation of synaptic transmission, GABAergic (GO:0032228)2.76051688
169neurotransmitter transport (GO:0006836)2.75895065
170innervation (GO:0060384)2.74972675
171regulation of female receptivity (GO:0045924)2.73846543
172protein-cofactor linkage (GO:0018065)2.73484416
173regulation of mitochondrial fission (GO:0090140)2.70114296
174positive regulation of membrane potential (GO:0045838)2.69408888
175synaptic transmission, dopaminergic (GO:0001963)2.67684468
176synaptic vesicle maturation (GO:0016188)2.66655671
177regulation of synaptic transmission, glutamatergic (GO:0051966)2.65751822
178regulation of neurotransmitter transport (GO:0051588)2.65289977
179behavioral fear response (GO:0001662)2.65007300
180behavioral defense response (GO:0002209)2.65007300
181mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63313016
182regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61693094
183exploration behavior (GO:0035640)2.61230481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.44115540
2GBX2_23144817_ChIP-Seq_PC3_Human4.23018308
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.91659800
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90867279
5TAF15_26573619_Chip-Seq_HEK293_Human2.90770081
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82899967
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79189211
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.73248090
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.69849557
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68122833
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66842050
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53009759
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.50174565
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46620125
15* EZH2_27304074_Chip-Seq_ESCs_Mouse2.45290434
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.40087942
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39915406
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36660457
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33294198
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29954426
21REST_21632747_ChIP-Seq_MESCs_Mouse2.29365194
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28671318
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28671318
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28371840
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26491795
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25754903
27XRN2_22483619_ChIP-Seq_HELA_Human2.24779036
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22429957
29* GABP_19822575_ChIP-Seq_HepG2_Human2.19666327
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19095259
31VDR_23849224_ChIP-Seq_CD4+_Human2.16494601
32FOXP3_21729870_ChIP-Seq_TREG_Human2.12649312
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08857419
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05456166
35REST_18959480_ChIP-ChIP_MESCs_Mouse2.05385652
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97120773
37DCP1A_22483619_ChIP-Seq_HELA_Human1.96339896
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95711515
39RNF2_27304074_Chip-Seq_NSC_Mouse1.87786845
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86436899
41P300_19829295_ChIP-Seq_ESCs_Human1.84293984
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83498667
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82305422
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82238549
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81084565
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.80543334
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78532870
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77335306
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.77020132
50VDR_22108803_ChIP-Seq_LS180_Human1.75051041
51* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73191823
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72714987
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72607706
54TTF2_22483619_ChIP-Seq_HELA_Human1.71595314
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.70366056
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68388467
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67362124
58FUS_26573619_Chip-Seq_HEK293_Human1.65571906
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62632962
60* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.61877664
61* RARB_27405468_Chip-Seq_BRAIN_Mouse1.61534555
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59615669
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58226835
64SMAD4_21799915_ChIP-Seq_A2780_Human1.57551809
65* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56488298
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55384845
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52937670
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52794811
69* TET1_21451524_ChIP-Seq_MESCs_Mouse1.51611150
70* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50340964
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49341929
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47350628
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.46816644
74CIITA_25753668_ChIP-Seq_RAJI_Human1.45920180
75* KDM5A_27292631_Chip-Seq_BREAST_Human1.44775780
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44544777
77IGF1R_20145208_ChIP-Seq_DFB_Human1.43820803
78* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43801891
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.42333147
80* ELF1_20517297_ChIP-Seq_JURKAT_Human1.41358208
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39699340
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39262160
83BCL6_27268052_Chip-Seq_Bcells_Human1.38294531
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37030425
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.36970833
86* P68_20966046_ChIP-Seq_HELA_Human1.35889788
87* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35382365
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35190266
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.34934573
90* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34427049
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33783186
92JUN_21703547_ChIP-Seq_K562_Human1.33254870
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33209994
94* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33114099
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31629007
96HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31241098
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30171830
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.29826401
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29812637
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29508703
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29193785
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28322497
103MYC_18940864_ChIP-ChIP_HL60_Human1.27039815
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26553178
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25469168
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24143882
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.23376203
108* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22958446
109E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22046257
110CTCF_26484167_Chip-Seq_Bcells_Mouse1.21793027
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21369269
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19854486
113* BCOR_27268052_Chip-Seq_Bcells_Human1.18218292
114SOX9_26525672_Chip-Seq_HEART_Mouse1.15753831
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14850950
116EWS_26573619_Chip-Seq_HEK293_Human1.14565204
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14389386
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14324319
119* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13895288
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13825512
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13750864
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12279719
123CTCF_20526341_ChIP-Seq_ESCs_Human1.11272251
124GABP_17652178_ChIP-ChIP_JURKAT_Human1.08731497
125RARB_24833708_ChIP-Seq_LIVER_Mouse1.08452039
126* PHF8_20622854_ChIP-Seq_HELA_Human1.08367854
127* AR_25329375_ChIP-Seq_VCAP_Human1.08283237
128E2F1_20622854_ChIP-Seq_HELA_Human1.07770090
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07720964
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07688843
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07188779
132PRDM14_20953172_ChIP-Seq_ESCs_Human1.06837047
133ELK1_19687146_ChIP-ChIP_HELA_Human1.06562536
134PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.04929489
135ER_23166858_ChIP-Seq_MCF-7_Human1.04123820
136* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02912273
137NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02672212
138SA1_27219007_Chip-Seq_Bcells_Human1.00879360
139* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00435643
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00399522
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00042066
142AR_21572438_ChIP-Seq_LNCaP_Human0.99959110
143* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97179135
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.96227642
145ETS1_20019798_ChIP-Seq_JURKAT_Human0.95700963
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94860294
147LXR_22292898_ChIP-Seq_THP-1_Human0.94769739
148SRF_21415370_ChIP-Seq_HL-1_Mouse0.93653826
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.93620870
150E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93416233
151SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93401416
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.92923044
153FLI1_27457419_Chip-Seq_LIVER_Mouse0.92767867
154* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92098130
155RUNX2_22187159_ChIP-Seq_PCA_Human0.91716349
156PIAS1_25552417_ChIP-Seq_VCAP_Human0.90799608
157PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90556907
158* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90554980
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90360710
160ZNF274_21170338_ChIP-Seq_K562_Hela0.90353574
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90346900
162E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90307929
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90177697
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89992645
165PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89990601
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89782251
167RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89581317
168CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89090251
169* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87513752
170IRF1_19129219_ChIP-ChIP_H3396_Human0.85736719
171RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84497174
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84454525
173CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84445298
174* SOX2_21211035_ChIP-Seq_LN229_Gbm0.84150437
175P53_22387025_ChIP-Seq_ESCs_Mouse0.82357827
176GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82292370
177EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81936507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.05716714
2MP0004859_abnormal_synaptic_plasticity3.74346088
3MP0001968_abnormal_touch/_nociception3.29805614
4MP0003635_abnormal_synaptic_transmissio3.22081758
5MP0002736_abnormal_nociception_after3.18755446
6MP0009046_muscle_twitch3.08861127
7MP0009745_abnormal_behavioral_response3.02776934
8MP0003806_abnormal_nucleotide_metabolis3.00764763
9MP0002735_abnormal_chemical_nociception2.98553320
10MP0004270_analgesia2.95104725
11MP0002064_seizures2.86213165
12MP0006276_abnormal_autonomic_nervous2.82065797
13MP0003693_abnormal_embryo_hatching2.77277437
14MP0002063_abnormal_learning/memory/cond2.73392284
15MP0001529_abnormal_vocalization2.66111049
16MP0002272_abnormal_nervous_system2.58233287
17MP0002572_abnormal_emotion/affect_behav2.55448019
18MP0002734_abnormal_mechanical_nocicepti2.45669185
19MP0003122_maternal_imprinting2.38033658
20MP0005646_abnormal_pituitary_gland2.20076045
21MP0001188_hyperpigmentation2.15723480
22MP0001905_abnormal_dopamine_level2.12704312
23MP0008058_abnormal_DNA_repair2.11460269
24MP0002067_abnormal_sensory_capabilities2.05086051
25MP0002822_catalepsy2.00901346
26MP0004142_abnormal_muscle_tone2.00581902
27MP0001486_abnormal_startle_reflex1.99446953
28MP0001970_abnormal_pain_threshold1.94393115
29MP0006036_abnormal_mitochondrial_physio1.93782322
30MP0003786_premature_aging1.90795544
31MP0005075_abnormal_melanosome_morpholog1.90075148
32MP0002733_abnormal_thermal_nociception1.89890421
33MP0001984_abnormal_olfaction1.89787510
34MP0001501_abnormal_sleep_pattern1.85628899
35MP0001440_abnormal_grooming_behavior1.85098433
36MP0002184_abnormal_innervation1.83594920
37MP0003787_abnormal_imprinting1.81840978
38MP0002277_abnormal_respiratory_mucosa1.79532071
39MP0005671_abnormal_response_to1.74747337
40MP0002876_abnormal_thyroid_physiology1.73634715
41MP0001873_stomach_inflammation1.71672505
42MP0002557_abnormal_social/conspecific_i1.65595754
43MP0000778_abnormal_nervous_system1.64018660
44MP0002254_reproductive_system_inflammat1.62325034
45MP0001346_abnormal_lacrimal_gland1.62175294
46MP0005499_abnormal_olfactory_system1.59393299
47MP0005394_taste/olfaction_phenotype1.59393299
48MP0010030_abnormal_orbit_morphology1.55585066
49MP0005386_behavior/neurological_phenoty1.55026327
50MP0004924_abnormal_behavior1.55026327
51MP0009333_abnormal_splenocyte_physiolog1.53352455
52MP0008875_abnormal_xenobiotic_pharmacok1.51948114
53MP0005310_abnormal_salivary_gland1.50740849
54MP0004133_heterotaxia1.49339336
55MP0002751_abnormal_autonomic_nervous1.48167063
56MP0004957_abnormal_blastocyst_morpholog1.48122371
57MP0003111_abnormal_nucleus_morphology1.47425816
58MP0005423_abnormal_somatic_nervous1.46978285
59MP0003718_maternal_effect1.45324465
60MP0005645_abnormal_hypothalamus_physiol1.44760742
61MP0001986_abnormal_taste_sensitivity1.44337872
62MP0003011_delayed_dark_adaptation1.42040875
63MP0002102_abnormal_ear_morphology1.41154771
64MP0008789_abnormal_olfactory_epithelium1.40505640
65MP0004811_abnormal_neuron_physiology1.39387543
66MP0004858_abnormal_nervous_system1.39047873
67MP0008569_lethality_at_weaning1.37283209
68MP0002938_white_spotting1.33900960
69MP0000955_abnormal_spinal_cord1.33273541
70MP0008007_abnormal_cellular_replicative1.32673691
71MP0006072_abnormal_retinal_apoptosis1.31470173
72MP0002882_abnormal_neuron_morphology1.30319629
73MP0010094_abnormal_chromosome_stability1.29949448
74MP0005171_absent_coat_pigmentation1.29824880
75MP0002653_abnormal_ependyma_morphology1.29042873
76MP0003879_abnormal_hair_cell1.28755909
77MP0003186_abnormal_redox_activity1.26552236
78MP0005377_hearing/vestibular/ear_phenot1.23398988
79MP0003878_abnormal_ear_physiology1.23398988
80MP0002066_abnormal_motor_capabilities/c1.23281730
81MP0006292_abnormal_olfactory_placode1.22817178
82MP0002234_abnormal_pharynx_morphology1.20528719
83MP0008877_abnormal_DNA_methylation1.17238737
84MP0001963_abnormal_hearing_physiology1.14717655
85MP0002837_dystrophic_cardiac_calcinosis1.12429538
86MP0003121_genomic_imprinting1.11476916
87MP0010386_abnormal_urinary_bladder1.09984421
88MP0005409_darkened_coat_color1.09972769
89MP0000631_abnormal_neuroendocrine_gland1.07564519
90MP0002148_abnormal_hypersensitivity_rea1.04141575
91MP0001764_abnormal_homeostasis1.03850149
92MP0008932_abnormal_embryonic_tissue1.03535612
93MP0002638_abnormal_pupillary_reflex1.03092385
94MP0002163_abnormal_gland_morphology1.02830613
95MP0001502_abnormal_circadian_rhythm1.00721824
96MP0004742_abnormal_vestibular_system1.00144385
97MP0000026_abnormal_inner_ear0.99534237
98MP0000538_abnormal_urinary_bladder0.98175467
99MP0002752_abnormal_somatic_nervous0.98138955
100MP0002152_abnormal_brain_morphology0.94789176
101MP0001919_abnormal_reproductive_system0.91178655
102MP0000372_irregular_coat_pigmentation0.90555365
103MP0003077_abnormal_cell_cycle0.90241070
104MP0002229_neurodegeneration0.88876055
105MP0002693_abnormal_pancreas_physiology0.88808399
106MP0000537_abnormal_urethra_morphology0.86030254
107MP0008872_abnormal_physiological_respon0.85861112
108MP0008961_abnormal_basal_metabolism0.85809520
109MP0001485_abnormal_pinna_reflex0.84820984
110MP0009780_abnormal_chondrocyte_physiolo0.84072912
111MP0000751_myopathy0.83688016
112MP0003137_abnormal_impulse_conducting0.83538095
113MP0003136_yellow_coat_color0.83184555
114MP0009379_abnormal_foot_pigmentation0.81109562
115MP0006035_abnormal_mitochondrial_morpho0.81029374
116MP0000015_abnormal_ear_pigmentation0.80500585
117MP0003938_abnormal_ear_development0.80251143
118MP0003329_amyloid_beta_deposits0.78493791
119MP0008995_early_reproductive_senescence0.77506994
120MP0001293_anophthalmia0.77309981
121MP0000358_abnormal_cell_content/0.77270107
122MP0008260_abnormal_autophagy0.77250884
123MP0005084_abnormal_gallbladder_morpholo0.75447395
124MP0004085_abnormal_heartbeat0.74652021
125MP0002160_abnormal_reproductive_system0.74109827
126MP0002069_abnormal_eating/drinking_beha0.72982365
127MP0000049_abnormal_middle_ear0.72541308
128MP0005253_abnormal_eye_physiology0.72307351
129MP0003123_paternal_imprinting0.72028317
130MP0003631_nervous_system_phenotype0.70596138
131MP0004145_abnormal_muscle_electrophysio0.67953285
132MP0003646_muscle_fatigue0.66973033
133MP0002210_abnormal_sex_determination0.66389644
134MP0001664_abnormal_digestion0.65597277
135MP0003315_abnormal_perineum_morphology0.64782286
136MP0000681_abnormal_thyroid_gland0.64726325
137MP0001348_abnormal_lacrimal_gland0.64546394
138MP0002090_abnormal_vision0.64146209
139MP0003698_abnormal_male_reproductive0.64123731
140MP0000566_synostosis0.60756321
141MP0003633_abnormal_nervous_system0.60371586
142MP0005551_abnormal_eye_electrophysiolog0.59682318
143MP0001943_abnormal_respiration0.58419808
144MP0005379_endocrine/exocrine_gland_phen0.57780285
145MP0004147_increased_porphyrin_level0.57495547
146MP0001177_atelectasis0.57288415
147MP0004885_abnormal_endolymph0.56999292
148MP0002332_abnormal_exercise_endurance0.54713369

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.46644703
2Atonic seizures (HP:0010819)5.22343676
3Febrile seizures (HP:0002373)4.91161553
4Myokymia (HP:0002411)4.51684560
5Acute necrotizing encephalopathy (HP:0006965)4.48411976
6Epileptic encephalopathy (HP:0200134)4.31766122
7Abnormal mitochondria in muscle tissue (HP:0008316)4.09394317
8Mitochondrial inheritance (HP:0001427)4.02036309
9Abnormal hair whorl (HP:0010721)3.95652758
10Progressive macrocephaly (HP:0004481)3.84016081
11Focal seizures (HP:0007359)3.79788161
12Hepatocellular necrosis (HP:0001404)3.67206105
13Hypothermia (HP:0002045)3.58627013
14Testicular atrophy (HP:0000029)3.57982784
15Pheochromocytoma (HP:0002666)3.50600349
16Increased CSF lactate (HP:0002490)3.49303739
17Hyperventilation (HP:0002883)3.41001682
18Neuroendocrine neoplasm (HP:0100634)3.37979542
19Absence seizures (HP:0002121)3.36870330
20Acute encephalopathy (HP:0006846)3.20504623
21Abnormal number of erythroid precursors (HP:0012131)3.20198686
22Increased intramyocellular lipid droplets (HP:0012240)3.19444298
23Gait imbalance (HP:0002141)3.17898869
24Lipid accumulation in hepatocytes (HP:0006561)3.16374195
25Dialeptic seizures (HP:0011146)3.15691008
26Medial flaring of the eyebrow (HP:0010747)3.08994918
27Congenital primary aphakia (HP:0007707)3.07507088
28Failure to thrive in infancy (HP:0001531)3.03363933
29Nephrogenic diabetes insipidus (HP:0009806)3.01953495
30Type I transferrin isoform profile (HP:0003642)3.00542962
31Progressive cerebellar ataxia (HP:0002073)2.99525984
32Aplastic anemia (HP:0001915)2.98898139
33Cerebral edema (HP:0002181)2.96516780
34Visual hallucinations (HP:0002367)2.92958514
35Methylmalonic aciduria (HP:0012120)2.90379654
36Poor suck (HP:0002033)2.89557163
37Microretrognathia (HP:0000308)2.89396996
38Increased muscle lipid content (HP:0009058)2.80394608
39Abnormality of glycolysis (HP:0004366)2.79219266
40Increased serum pyruvate (HP:0003542)2.79219266
41Optic disc pallor (HP:0000543)2.71563196
42Generalized tonic-clonic seizures (HP:0002069)2.61173374
43Abnormality of cells of the erythroid lineage (HP:0012130)2.61057004
44Amblyopia (HP:0000646)2.60312996
45Abnormal protein glycosylation (HP:0012346)2.58140435
46Abnormal glycosylation (HP:0012345)2.58140435
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58140435
48Abnormal protein N-linked glycosylation (HP:0012347)2.58140435
49Hepatic necrosis (HP:0002605)2.57276810
50Narrow nasal bridge (HP:0000446)2.44292933
51Polyphagia (HP:0002591)2.42635112
52Genital tract atresia (HP:0001827)2.41234315
53Broad-based gait (HP:0002136)2.40837032
54Vaginal atresia (HP:0000148)2.39734711
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37025502
56Abnormality of alanine metabolism (HP:0010916)2.37025502
57Hyperalaninemia (HP:0003348)2.37025502
58Abnormality of the labia minora (HP:0012880)2.35409671
59Limb dystonia (HP:0002451)2.34966418
60Methylmalonic acidemia (HP:0002912)2.34901860
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30129166
62Dicarboxylic aciduria (HP:0003215)2.30129166
63Progressive microcephaly (HP:0000253)2.29134741
64Poor coordination (HP:0002370)2.26556438
65Pancreatic cysts (HP:0001737)2.23803622
66Fetal akinesia sequence (HP:0001989)2.21907507
67Specific learning disability (HP:0001328)2.21593729
68Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20495272
69Degeneration of the lateral corticospinal tracts (HP:0002314)2.20495272
70Respiratory failure (HP:0002878)2.20457777
71Microvesicular hepatic steatosis (HP:0001414)2.19784613
72Pancytopenia (HP:0001876)2.17687604
73Lethargy (HP:0001254)2.17155784
74CNS hypomyelination (HP:0003429)2.17074883
75Delusions (HP:0000746)2.17009053
76Exercise intolerance (HP:0003546)2.16897649
77Abnormal eating behavior (HP:0100738)2.15684571
78Lactic acidosis (HP:0003128)2.13944844
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12397044
80Anxiety (HP:0000739)2.11827319
81Leukodystrophy (HP:0002415)2.10038637
82Molar tooth sign on MRI (HP:0002419)2.09492610
83Abnormality of midbrain morphology (HP:0002418)2.09492610
84Opisthotonus (HP:0002179)2.08553030
85Esotropia (HP:0000565)2.08091447
86Sleep apnea (HP:0010535)2.07854130
87Increased serum lactate (HP:0002151)2.07611492
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06897249
89Exertional dyspnea (HP:0002875)2.05677917
903-Methylglutaconic aciduria (HP:0003535)2.04626384
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03267455
92Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03267455
93True hermaphroditism (HP:0010459)2.03259990
94Gaze-evoked nystagmus (HP:0000640)2.02414711
95Oral leukoplakia (HP:0002745)2.01991649
96CNS demyelination (HP:0007305)2.00494457
97Rough bone trabeculation (HP:0100670)2.00435261
98Emotional lability (HP:0000712)1.97911325
99Aplasia/Hypoplasia of the lens (HP:0008063)1.97846000
100Degeneration of anterior horn cells (HP:0002398)1.97140205
101Abnormality of the anterior horn cell (HP:0006802)1.97140205
102Aplasia/hypoplasia of the uterus (HP:0008684)1.97107301
103Cleft eyelid (HP:0000625)1.95899703
104Impaired pain sensation (HP:0007328)1.95514702
105Abnormality of pain sensation (HP:0010832)1.95514702
106Generalized hypotonia (HP:0001290)1.94563934
107Neoplasm of the peripheral nervous system (HP:0100007)1.94067445
108Epileptiform EEG discharges (HP:0011182)1.93394922
109Sclerocornea (HP:0000647)1.92276850
110Congenital stationary night blindness (HP:0007642)1.91402282
111Oligomenorrhea (HP:0000876)1.90964846
112Pancreatic fibrosis (HP:0100732)1.90775315
113Progressive inability to walk (HP:0002505)1.90646311
114Increased hepatocellular lipid droplets (HP:0006565)1.87606043
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87107564
116Severe muscular hypotonia (HP:0006829)1.86365587
117Retinal dysplasia (HP:0007973)1.85982847
118Neoplasm of the adrenal gland (HP:0100631)1.85746236
119Truncal ataxia (HP:0002078)1.85479954
120Hypoventilation (HP:0002791)1.84160149
121IgG deficiency (HP:0004315)1.82903374
122Inability to walk (HP:0002540)1.82878769
123Cerebral hypomyelination (HP:0006808)1.80817044
124Pendular nystagmus (HP:0012043)1.80242070
125Abnormality of the corticospinal tract (HP:0002492)1.78602715
126X-linked dominant inheritance (HP:0001423)1.77235899
127Unsteady gait (HP:0002317)1.76504866
128Sensory axonal neuropathy (HP:0003390)1.73733077
129Heterochromia iridis (HP:0001100)1.73176616
130Increased IgM level (HP:0003496)1.72663117
131Brushfield spots (HP:0001088)1.71759823
132Abnormal gallbladder physiology (HP:0012438)1.71339614
133Cholecystitis (HP:0001082)1.71339614
134Protruding tongue (HP:0010808)1.70729092
135Patellar aplasia (HP:0006443)1.70366869
136Cerebral palsy (HP:0100021)1.69929864
137Abnormal biliary tract physiology (HP:0012439)1.69561874
138Bile duct proliferation (HP:0001408)1.69561874
139EEG with generalized epileptiform discharges (HP:0011198)1.68908831
140Incomplete penetrance (HP:0003829)1.68754023
141Respiratory difficulties (HP:0002880)1.68545950
142Neuroblastic tumors (HP:0004376)1.66534999
143Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.66534999
144Neuroblastoma (HP:0003006)1.66534999
145Primitive neuroectodermal tumor (HP:0030065)1.66534999
146Gliosis (HP:0002171)1.65596317
147Congenital, generalized hypertrichosis (HP:0004540)1.65167279
148Short tibia (HP:0005736)1.64730612
149Abnormal trabecular bone morphology (HP:0100671)1.63642171
150Tongue fasciculations (HP:0001308)1.63595281
151Optic nerve coloboma (HP:0000588)1.63249726
152Aplasia/Hypoplasia of the patella (HP:0006498)1.63188829
153Nephronophthisis (HP:0000090)1.61654978
154Death in infancy (HP:0001522)1.61128658
155Sparse eyelashes (HP:0000653)1.61025112
156Impaired vibration sensation in the lower limbs (HP:0002166)1.60734274
157Renal Fanconi syndrome (HP:0001994)1.60669150
158Abnormality of renal resorption (HP:0011038)1.60205312
159Aplasia/Hypoplasia of the tibia (HP:0005772)1.60079207
160Ankle clonus (HP:0011448)1.59678839
161Broad foot (HP:0001769)1.59233998
162Hypoplasia of the pons (HP:0012110)1.58424890
163Blindness (HP:0000618)1.58373817
164Scanning speech (HP:0002168)1.58023859
165Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.57832375
166Hypsarrhythmia (HP:0002521)1.57204270
167Generalized aminoaciduria (HP:0002909)1.56961263
168Autoamputation (HP:0001218)1.56533291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.95700944
2VRK25.37096952
3MAP3K124.01993157
4TESK23.99782693
5PRPF4B3.15780331
6MAP2K73.05364581
7BCKDK3.03413244
8NME22.92913279
9NTRK32.82265962
10AKT32.81726839
11TESK12.71877644
12SIK32.48005805
13TLK12.26737358
14PLK22.24580173
15MINK12.16367184
16TSSK62.11651150
17EPHA42.08962625
18CDK192.07698323
19ZAK2.04833579
20MAP3K41.97191819
21ARAF1.91057125
22TAOK11.84066210
23BMPR21.83499871
24KDR1.82227675
25TRIM281.79598805
26DAPK11.77647802
27MAP3K111.76507453
28STK161.70762998
29PRKCI1.63483358
30MAPK131.55822638
31SGK21.55620389
32BCR1.48714440
33NME11.48639307
34MAP4K21.44357130
35CSNK1G31.42555928
36GRK51.41100440
37SGK2231.41066068
38SGK4941.41066068
39CCNB11.37313008
40MARK11.36777976
41BRAF1.36115702
42MYLK1.30408892
43DAPK21.26893885
44NUAK11.26875620
45OXSR11.23738630
46NTRK21.22024846
47MKNK21.19256285
48CAMK1D1.17139759
49PRKCG1.16760398
50CSNK1G11.16383156
51MAP2K41.15617357
52ERBB31.14915537
53GRK71.14858256
54RIPK41.14465447
55PAK61.13106992
56MAPKAPK31.11424389
57INSRR1.08687190
58MKNK11.06770440
59LIMK11.06723690
60ADRBK21.06668510
61CSNK1G21.05953693
62TNIK1.05877768
63MUSK1.04325414
64YES11.04208924
65UHMK10.99708731
66BMPR1B0.97251797
67CSNK1A1L0.96937478
68PNCK0.96524495
69EPHA20.95117850
70MAP4K10.94943637
71KSR10.94375607
72SMG10.90719930
73PLK30.90250670
74CAMK2A0.89897216
75CDC70.83144327
76TXK0.83049561
77GRK10.82973864
78CDK50.81514297
79PINK10.80186441
80CAMK2B0.79982828
81CDK180.79336871
82BUB10.78321739
83PBK0.76858939
84ADRBK10.76154807
85PRKCE0.75469328
86SGK30.74628365
87EIF2AK10.73579471
88CDK80.72650524
89MAP3K90.70336884
90SRPK10.70279653
91CDK140.68105275
92PLK10.66272115
93NTRK10.66005668
94ATR0.65147680
95VRK10.64025347
96CDK150.63376693
97BRSK10.63185714
98TNK20.62390408
99RPS6KA50.62064146
100IRAK30.60678769
101PASK0.59856057
102MST40.59281555
103DAPK30.58625140
104PAK40.57618263
105PRKD20.57489913
106MAP2K60.56860893
107EIF2AK30.56755798
108NEK60.55694557
109RPS6KA20.55402111
110PIM20.54359350
111CDK11A0.54273885
112PTK2B0.54265790
113CAMKK10.53691875
114PAK10.52774666
115CAMKK20.50545970
116AURKB0.49387256
117DYRK1A0.48421327
118DYRK20.48029690
119GRK60.47630451
120IKBKB0.47220119
121ROCK20.46519933
122AURKA0.46198769
123FES0.44471895
124CAMK2D0.43174696
125CSNK2A10.42864336
126CAMK2G0.42440547
127MAPKAPK50.42014352
128ABL20.40949998
129CHEK20.40107408
130WNK40.39890397
131ILK0.39493185
132EIF2AK20.39261210
133RPS6KB10.39188859
134FGR0.37477575
135PRKACA0.36826734
136PLK40.36824762
137STK240.36033054
138MAP2K10.35449319
139TBK10.35038209
140CSNK2A20.33215633
141SGK10.33119130
142PHKG10.32531072
143PHKG20.32531072
144IRAK20.32357341
145RPS6KA40.31577721
146RPS6KC10.30484951
147RPS6KL10.30484951
148WNK30.29389687
149FER0.27170684
150CDK30.27083305
151STK38L0.25293001
152NEK10.25056800
153RPS6KA60.24115728
154CAMK10.23498704
155CSNK1A10.22327234

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.95028385
2Synaptic vesicle cycle_Homo sapiens_hsa047213.86988399
3Nicotine addiction_Homo sapiens_hsa050333.68810070
4Collecting duct acid secretion_Homo sapiens_hsa049663.59023656
5Parkinsons disease_Homo sapiens_hsa050123.14045218
6Proteasome_Homo sapiens_hsa030502.58512765
7Alzheimers disease_Homo sapiens_hsa050102.50793316
8Olfactory transduction_Homo sapiens_hsa047402.47233789
9Vibrio cholerae infection_Homo sapiens_hsa051102.46080880
10DNA replication_Homo sapiens_hsa030302.45185757
11Huntingtons disease_Homo sapiens_hsa050162.38276888
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35597934
13GABAergic synapse_Homo sapiens_hsa047272.09614685
14Base excision repair_Homo sapiens_hsa034102.04694081
15Circadian entrainment_Homo sapiens_hsa047132.01430171
16Morphine addiction_Homo sapiens_hsa050322.00103472
17Long-term potentiation_Homo sapiens_hsa047201.96721197
18Amphetamine addiction_Homo sapiens_hsa050311.94578649
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.89557088
20Sulfur relay system_Homo sapiens_hsa041221.82869239
21Homologous recombination_Homo sapiens_hsa034401.80554226
22Taste transduction_Homo sapiens_hsa047421.79255409
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77705538
24Mismatch repair_Homo sapiens_hsa034301.77274860
25Serotonergic synapse_Homo sapiens_hsa047261.76211617
26Dopaminergic synapse_Homo sapiens_hsa047281.75987143
27Glutamatergic synapse_Homo sapiens_hsa047241.71419737
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66625984
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63610371
30Cardiac muscle contraction_Homo sapiens_hsa042601.59534146
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55624059
32Phototransduction_Homo sapiens_hsa047441.50252014
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48962702
34Primary immunodeficiency_Homo sapiens_hsa053401.45098442
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38848445
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.38466122
37Long-term depression_Homo sapiens_hsa047301.32990858
38Rheumatoid arthritis_Homo sapiens_hsa053231.30353999
39Salivary secretion_Homo sapiens_hsa049701.25913122
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25101162
41Calcium signaling pathway_Homo sapiens_hsa040201.23079067
42Cholinergic synapse_Homo sapiens_hsa047251.21788454
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20844186
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19932260
45Nucleotide excision repair_Homo sapiens_hsa034201.19547714
46Insulin secretion_Homo sapiens_hsa049111.16214960
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14604617
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.09520514
49Renin secretion_Homo sapiens_hsa049241.07425592
50Glutathione metabolism_Homo sapiens_hsa004801.06509847
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06173266
52Phagosome_Homo sapiens_hsa041451.04463248
53Cocaine addiction_Homo sapiens_hsa050301.03373209
54RNA polymerase_Homo sapiens_hsa030200.99523283
55RNA transport_Homo sapiens_hsa030130.99305349
56Gap junction_Homo sapiens_hsa045400.97205363
57Gastric acid secretion_Homo sapiens_hsa049710.96490998
58Biosynthesis of amino acids_Homo sapiens_hsa012300.92547764
59Oxytocin signaling pathway_Homo sapiens_hsa049210.92327934
60Fanconi anemia pathway_Homo sapiens_hsa034600.92150839
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90923629
62Peroxisome_Homo sapiens_hsa041460.88609722
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.87307975
64Type I diabetes mellitus_Homo sapiens_hsa049400.86320345
65Oocyte meiosis_Homo sapiens_hsa041140.85667625
66Non-homologous end-joining_Homo sapiens_hsa034500.84116635
67Folate biosynthesis_Homo sapiens_hsa007900.83850118
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81739638
69One carbon pool by folate_Homo sapiens_hsa006700.80433816
70Axon guidance_Homo sapiens_hsa043600.79624115
71N-Glycan biosynthesis_Homo sapiens_hsa005100.78306248
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76488799
73Steroid biosynthesis_Homo sapiens_hsa001000.76222600
74Protein export_Homo sapiens_hsa030600.75746341
75Carbon metabolism_Homo sapiens_hsa012000.75108828
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75074174
77Antigen processing and presentation_Homo sapiens_hsa046120.75072794
78Vitamin B6 metabolism_Homo sapiens_hsa007500.73229085
79Melanogenesis_Homo sapiens_hsa049160.71183485
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70261359
81Fatty acid elongation_Homo sapiens_hsa000620.68984777
82Alcoholism_Homo sapiens_hsa050340.68203142
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65792743
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.64827942
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64314064
86Selenocompound metabolism_Homo sapiens_hsa004500.63531066
87Graft-versus-host disease_Homo sapiens_hsa053320.63323545
88GnRH signaling pathway_Homo sapiens_hsa049120.61156152
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60937392
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60878062
91Allograft rejection_Homo sapiens_hsa053300.60685533
92Propanoate metabolism_Homo sapiens_hsa006400.59992578
93Autoimmune thyroid disease_Homo sapiens_hsa053200.59622194
94Sulfur metabolism_Homo sapiens_hsa009200.58968805
95Arginine and proline metabolism_Homo sapiens_hsa003300.57190913
96cAMP signaling pathway_Homo sapiens_hsa040240.55709237
97Asthma_Homo sapiens_hsa053100.55139886
98Fatty acid biosynthesis_Homo sapiens_hsa000610.53652281
99ErbB signaling pathway_Homo sapiens_hsa040120.53064685
100Basal transcription factors_Homo sapiens_hsa030220.51112962
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50046509
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49578160
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49156274
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48864896
105Fatty acid metabolism_Homo sapiens_hsa012120.48570740
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47338367
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.47019399
108Regulation of autophagy_Homo sapiens_hsa041400.46364443
109Nitrogen metabolism_Homo sapiens_hsa009100.46225822
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46219481
111Purine metabolism_Homo sapiens_hsa002300.43865017
112Pyruvate metabolism_Homo sapiens_hsa006200.43485059
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42289838
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38983227
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38675039
116Ras signaling pathway_Homo sapiens_hsa040140.37174491
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35431532
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34982494
119Glioma_Homo sapiens_hsa052140.34698238
120Wnt signaling pathway_Homo sapiens_hsa043100.34349999
121Melanoma_Homo sapiens_hsa052180.33334456
122MAPK signaling pathway_Homo sapiens_hsa040100.32818734
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32796233
124Pentose phosphate pathway_Homo sapiens_hsa000300.31063056
125Estrogen signaling pathway_Homo sapiens_hsa049150.29605063
126Linoleic acid metabolism_Homo sapiens_hsa005910.29226668
127Butanoate metabolism_Homo sapiens_hsa006500.25487795
128Epstein-Barr virus infection_Homo sapiens_hsa051690.24538487
129Arachidonic acid metabolism_Homo sapiens_hsa005900.23955769
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.23313936
131Prion diseases_Homo sapiens_hsa050200.22736501
132Ribosome_Homo sapiens_hsa030100.22459811
133Dilated cardiomyopathy_Homo sapiens_hsa054140.22345036
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21770158
135Tryptophan metabolism_Homo sapiens_hsa003800.21034119
136Pyrimidine metabolism_Homo sapiens_hsa002400.20560473
137Spliceosome_Homo sapiens_hsa030400.20340275
138Metabolic pathways_Homo sapiens_hsa011000.19751930
139African trypanosomiasis_Homo sapiens_hsa051430.18859212
140Hedgehog signaling pathway_Homo sapiens_hsa043400.17020269
141Galactose metabolism_Homo sapiens_hsa000520.15396459
142Lysosome_Homo sapiens_hsa041420.15355757
143Cell cycle_Homo sapiens_hsa041100.15024455
144Vitamin digestion and absorption_Homo sapiens_hsa049770.13622740
145Salmonella infection_Homo sapiens_hsa051320.12969345
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12633433
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.12523380
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12397737
149Inositol phosphate metabolism_Homo sapiens_hsa005620.11018850
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09916882
151Fructose and mannose metabolism_Homo sapiens_hsa000510.09693473
152Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09688418
153Ether lipid metabolism_Homo sapiens_hsa005650.08836621
154Pancreatic secretion_Homo sapiens_hsa049720.08792169
155RNA degradation_Homo sapiens_hsa030180.08551807

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