OSTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.26573776
2neutrophil activation involved in immune response (GO:0002283)5.16467260
3Arp2/3 complex-mediated actin nucleation (GO:0034314)4.48270761
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23856543
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23856543
6respiratory burst (GO:0045730)4.11913179
7antigen processing and presentation of endogenous antigen (GO:0019883)4.06273604
8cellular response to interleukin-15 (GO:0071350)3.99889983
9neutrophil activation (GO:0042119)3.90244168
10response to interleukin-15 (GO:0070672)3.86184091
11response to peptidoglycan (GO:0032494)3.82996164
12cytidine deamination (GO:0009972)3.81628337
13cytidine metabolic process (GO:0046087)3.81628337
14cytidine catabolic process (GO:0006216)3.81628337
15immunoglobulin mediated immune response (GO:0016064)3.79847499
16negative T cell selection (GO:0043383)3.79554562
17granulocyte activation (GO:0036230)3.78649057
18leukocyte aggregation (GO:0070486)3.78417096
19detection of other organism (GO:0098543)3.77067398
20regulation of B cell receptor signaling pathway (GO:0050855)3.72934028
21positive regulation of gamma-delta T cell activation (GO:0046645)3.69705784
22positive thymic T cell selection (GO:0045059)3.66420452
23detection of bacterium (GO:0016045)3.59550800
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.56883951
25regulation of regulatory T cell differentiation (GO:0045589)3.51988752
26negative thymic T cell selection (GO:0045060)3.47697227
27cellular extravasation (GO:0045123)3.44729076
28regulation of T cell tolerance induction (GO:0002664)3.44716635
29modulation by symbiont of host immune response (GO:0052553)3.41512464
30positive regulation by symbiont of host defense response (GO:0052509)3.41512464
31modulation by symbiont of host defense response (GO:0052031)3.41512464
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41512464
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41512464
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.41512464
35positive T cell selection (GO:0043368)3.41294846
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.40687655
37actin nucleation (GO:0045010)3.38165822
38regulation of natural killer cell mediated immunity (GO:0002715)3.33119874
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33119874
40positive regulation of interferon-alpha production (GO:0032727)3.32586098
41negative regulation of lymphocyte mediated immunity (GO:0002707)3.31730634
42detection of external biotic stimulus (GO:0098581)3.28776135
43NIK/NF-kappaB signaling (GO:0038061)3.28623545
44negative regulation of T cell mediated immunity (GO:0002710)3.24950516
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24832562
46positive regulation of antigen processing and presentation (GO:0002579)3.24608925
47regulation of alpha-beta T cell proliferation (GO:0046640)3.24389424
48detection of molecule of bacterial origin (GO:0032490)3.21882309
49microglial cell activation (GO:0001774)3.21652279
50regulation of tolerance induction (GO:0002643)3.19973249
51regulation of interferon-beta biosynthetic process (GO:0045357)3.19849732
52regulation of T cell mediated cytotoxicity (GO:0001914)3.18425354
53regulation of interferon-alpha production (GO:0032647)3.15249621
54negative regulation of leukocyte mediated immunity (GO:0002704)3.14902443
55mast cell activation (GO:0045576)3.14700068
56response to muramyl dipeptide (GO:0032495)3.13796935
57B cell mediated immunity (GO:0019724)3.13765128
58natural killer cell mediated immunity (GO:0002228)3.10492068
59natural killer cell mediated cytotoxicity (GO:0042267)3.10492068
60T cell migration (GO:0072678)3.09366565
61positive regulation of T cell mediated cytotoxicity (GO:0001916)3.07450141
62T cell selection (GO:0045058)3.05140636
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03098703
64regulation of leukocyte mediated cytotoxicity (GO:0001910)3.02580178
65dendritic cell chemotaxis (GO:0002407)3.02198677
66regulation of antigen processing and presentation (GO:0002577)2.99039499
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98858153
68cellular response to zinc ion (GO:0071294)2.98279106
69DNA deamination (GO:0045006)2.97029615
70cellular response to type I interferon (GO:0071357)2.95741260
71type I interferon signaling pathway (GO:0060337)2.95741260
72response to type I interferon (GO:0034340)2.95517090
73leukocyte mediated cytotoxicity (GO:0001909)2.95492238
74regulation of B cell differentiation (GO:0045577)2.93963145
75myeloid cell activation involved in immune response (GO:0002275)2.93734781
76dendritic cell migration (GO:0036336)2.93282978
77superoxide anion generation (GO:0042554)2.92652583
78negative regulation of phagocytosis (GO:0050765)2.91382933
79positive regulation of B cell differentiation (GO:0045579)2.90549877
80myeloid dendritic cell activation (GO:0001773)2.90455999
81positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.89664857
82interferon-gamma-mediated signaling pathway (GO:0060333)2.89191752
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88981655
84T cell costimulation (GO:0031295)2.87911309
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87345458
86detection of biotic stimulus (GO:0009595)2.85623041
87thymic T cell selection (GO:0045061)2.85395036
88positive regulation of natural killer cell mediated immunity (GO:0002717)2.85313759
89positive regulation of tolerance induction (GO:0002645)2.84878526
90sequestering of actin monomers (GO:0042989)2.84867994
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84729886
92hydrogen peroxide biosynthetic process (GO:0050665)2.84451926
93lymphocyte costimulation (GO:0031294)2.84009977
94macrophage activation (GO:0042116)2.83773459
95cellular defense response (GO:0006968)2.83620160
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82563260
97positive regulation of mast cell activation (GO:0033005)2.82260840
98reactive oxygen species biosynthetic process (GO:1903409)2.80580472
99interferon-gamma production (GO:0032609)2.78598198
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.78035058
101positive regulation of mast cell degranulation (GO:0043306)2.78035058
102myeloid dendritic cell differentiation (GO:0043011)2.76002499
103antigen receptor-mediated signaling pathway (GO:0050851)2.75744489
104regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74912643
105production of molecular mediator involved in inflammatory response (GO:0002532)2.73907469
106cellular response to interferon-beta (GO:0035458)2.73432405
107pinocytosis (GO:0006907)2.72837242
108regulation of mast cell activation (GO:0033003)2.72577376
109macrophage activation involved in immune response (GO:0002281)2.72538394
110regulation of mast cell degranulation (GO:0043304)2.71389372
111leukocyte cell-cell adhesion (GO:0007159)2.67159196
112positive regulation of macrophage differentiation (GO:0045651)2.66868995
113neutrophil mediated immunity (GO:0002446)2.66668639
114regulation of RIG-I signaling pathway (GO:0039535)2.64577222
115negative regulation of interleukin-12 production (GO:0032695)2.64205545
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.64084547
117response to interferon-beta (GO:0035456)2.63533802
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.62636500
119defense response to protozoan (GO:0042832)2.62505081
120response to protozoan (GO:0001562)2.60331521
121response to fungus (GO:0009620)2.59186915
122ribosomal small subunit assembly (GO:0000028)2.58071637
123regulation of dendritic cell antigen processing and presentation (GO:0002604)2.57722033
124leukocyte degranulation (GO:0043299)2.55986311
125B cell receptor signaling pathway (GO:0050853)2.55869872
126negative regulation of cell killing (GO:0031342)2.55459364
127negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.55459364
128positive regulation of lamellipodium assembly (GO:0010592)2.55312660
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55031176
130lymphocyte mediated immunity (GO:0002449)2.53120618
131regulation of mast cell activation involved in immune response (GO:0033006)2.52592181
132antigen processing and presentation via MHC class Ib (GO:0002475)2.52240697
133response to host immune response (GO:0052572)2.52141134
134response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.52141134
135dendritic cell differentiation (GO:0097028)2.52055310
136regulation of gamma-delta T cell differentiation (GO:0045586)2.51660047
137regulation of T-helper 1 cell differentiation (GO:0045625)2.50476534
138positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.50221484
139positive regulation of interferon-beta production (GO:0032728)2.49915306
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.49755514
141regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48970454
142regulation of gamma-delta T cell activation (GO:0046643)2.47884078
143myeloid leukocyte activation (GO:0002274)2.47810697
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.47264013
145tolerance induction (GO:0002507)2.46925413
146regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.46478615
147positive regulation of isotype switching (GO:0045830)2.46439227
148antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.46400890
149negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44442080
150positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43599972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.81440221
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.55750473
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.03594878
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35569945
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.33760656
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18429493
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.94343965
8* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87942716
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84960513
10E2F7_22180533_ChIP-Seq_HELA_Human2.84544532
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83370987
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75259902
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71438555
14* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69844266
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.55049505
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49432128
17* SPI1_23547873_ChIP-Seq_NB4_Human2.36027658
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33289816
19* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26551776
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22284790
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.21841052
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.14669960
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06340323
24VDR_21846776_ChIP-Seq_THP-1_Human2.01045887
25MYB_26560356_Chip-Seq_TH2_Human2.00986627
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96603050
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93779074
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89707463
29MAF_26560356_Chip-Seq_TH1_Human1.88110052
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.85348822
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82999041
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.81347708
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.80392837
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77348153
35* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75856828
36VDR_24763502_ChIP-Seq_THP-1_Human1.75118792
37MYB_26560356_Chip-Seq_TH1_Human1.71220289
38RUNX_20019798_ChIP-Seq_JUKART_Human1.62949371
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62931102
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62242569
41SCL_19346495_ChIP-Seq_HPC-7_Human1.60162880
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56703691
43MYC_22102868_ChIP-Seq_BL_Human1.53980391
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52429145
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49670978
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46957466
47UTX_26944678_Chip-Seq_JUKART_Human1.45503744
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42639589
49PU_27001747_Chip-Seq_BMDM_Mouse1.42374715
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38639377
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34474929
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33236729
53* SPI1_23127762_ChIP-Seq_K562_Human1.30700194
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.29360096
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27742194
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27070737
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.26142885
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26072519
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26067188
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25524958
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21848109
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20228184
63MAF_26560356_Chip-Seq_TH2_Human1.19697096
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.18971561
65TFEB_21752829_ChIP-Seq_HELA_Human1.16853017
66GATA1_19941826_ChIP-Seq_K562_Human1.15702521
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15699684
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15510467
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.15488045
70VDR_23849224_ChIP-Seq_CD4+_Human1.12520071
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11719904
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11586398
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11133439
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11109425
75GATA3_27048872_Chip-Seq_THYMUS_Human1.10914109
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09624520
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08752069
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08156235
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07536674
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07156265
81TCF7_22412390_ChIP-Seq_EML_Mouse1.06463151
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05978247
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05123659
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02705382
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01383270
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99125619
87GATA2_19941826_ChIP-Seq_K562_Human0.97984595
88VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97370211
89ELK1_19687146_ChIP-ChIP_HELA_Human0.96699651
90BCL6_27268052_Chip-Seq_Bcells_Human0.96360899
91GATA3_26560356_Chip-Seq_TH2_Human0.96143048
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94947059
93GATA1_22025678_ChIP-Seq_K562_Human0.94154030
94MYC_18555785_ChIP-Seq_MESCs_Mouse0.93859098
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93536091
96PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92334629
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90985102
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88882342
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88793254
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88718479
101STAT1_20625510_ChIP-Seq_HELA_Human0.88295125
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87784651
103CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87331043
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86465591
105* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85642876
106* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85449128
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84278474
108VDR_24787735_ChIP-Seq_THP-1_Human0.84261039
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83813526
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83680471
111FOXM1_23109430_ChIP-Seq_U2OS_Human0.83124422
112DCP1A_22483619_ChIP-Seq_HELA_Human0.82585026
113BCOR_27268052_Chip-Seq_Bcells_Human0.82124590
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.81176016
115SPI1_20517297_ChIP-Seq_HL60_Human0.80767166
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80570555
117SMRT_27268052_Chip-Seq_Bcells_Human0.77479472
118E2F4_17652178_ChIP-ChIP_JURKAT_Human0.77093848
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73606515
120PPARA_22158963_ChIP-Seq_LIVER_Mouse0.71388472
121TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70375184
122P300_27268052_Chip-Seq_Bcells_Human0.68147601
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.67685034
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67042261
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.66269270
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.66135745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.87170369
2MP0003436_decreased_susceptibility_to3.46842585
3MP0009785_altered_susceptibility_to3.23355508
4MP0002148_abnormal_hypersensitivity_rea2.83509195
5MP0000685_abnormal_immune_system2.83121566
6MP0005000_abnormal_immune_tolerance2.80181549
7MP0002419_abnormal_innate_immunity2.70791803
8MP0003724_increased_susceptibility_to2.69693951
9MP0005671_abnormal_response_to2.66699183
10MP0003303_peritoneal_inflammation2.65130888
11MP0005025_abnormal_response_to2.64558237
12MP0001790_abnormal_immune_system2.55559216
13MP0005387_immune_system_phenotype2.55559216
14MP0001800_abnormal_humoral_immune2.52202153
15MP0002452_abnormal_antigen_presenting2.49807845
16MP0006082_CNS_inflammation2.41000486
17MP0002723_abnormal_immune_serum2.37408636
18MP0001819_abnormal_immune_cell2.28982326
19MP0002420_abnormal_adaptive_immunity2.28527810
20MP0002405_respiratory_system_inflammati2.07745199
21MP0005058_abnormal_lysosome_morphology2.05561177
22MP0002166_altered_tumor_susceptibility2.00036495
23MP0001853_heart_inflammation1.98867404
24MP0005464_abnormal_platelet_physiology1.94081731
25MP0009333_abnormal_splenocyte_physiolog1.87813421
26MP0001533_abnormal_skeleton_physiology1.87449588
27MP0002006_tumorigenesis1.81298286
28MP0003763_abnormal_thymus_physiology1.81294385
29MP0002398_abnormal_bone_marrow1.81216829
30MP0001845_abnormal_inflammatory_respons1.78806918
31MP0000716_abnormal_immune_system1.78605829
32MP0004947_skin_inflammation1.78064579
33MP0010155_abnormal_intestine_physiology1.76511522
34MP0000858_altered_metastatic_potential1.74305070
35MP0004510_myositis1.70644991
36MP0002396_abnormal_hematopoietic_system1.68568684
37MP0001545_abnormal_hematopoietic_system1.65283841
38MP0005397_hematopoietic_system_phenotyp1.65283841
39MP0000343_altered_response_to1.59659119
40MP0003448_altered_tumor_morphology1.59396384
41MP0000689_abnormal_spleen_morphology1.57664648
42MP0009278_abnormal_bone_marrow1.55749215
43MP0002429_abnormal_blood_cell1.52308850
44MP0003806_abnormal_nucleotide_metabolis1.52139827
45MP0002722_abnormal_immune_system1.51836752
46MP0008469_abnormal_protein_level1.47090980
47MP0009840_abnormal_foam_cell1.45974330
48MP0009764_decreased_sensitivity_to1.45670544
49MP0001873_stomach_inflammation1.41773351
50MP0003300_gastrointestinal_ulcer1.40474655
51MP0003191_abnormal_cellular_cholesterol1.38289091
52MP0000490_abnormal_crypts_of1.34469541
53MP0010352_gastrointestinal_tract_polyps1.34155019
54MP0002138_abnormal_hepatobiliary_system1.33096540
55MP0002933_joint_inflammation1.32220092
56MP0004381_abnormal_hair_follicle1.26531359
57MP0000465_gastrointestinal_hemorrhage1.22720644
58MP0004808_abnormal_hematopoietic_stem1.20363013
59MP0003186_abnormal_redox_activity1.19629937
60MP0002998_abnormal_bone_remodeling1.18969925
61MP0003172_abnormal_lysosome_physiology1.18565202
62MP0005310_abnormal_salivary_gland1.17743918
63MP0003566_abnormal_cell_adhesion1.15275432
64MP0003693_abnormal_embryo_hatching1.13666090
65MP0003866_abnormal_defecation1.11652012
66MP0003828_pulmonary_edema1.07749317
67MP0005023_abnormal_wound_healing1.07602629
68MP0000604_amyloidosis1.06649702
69MP0008004_abnormal_stomach_pH1.05510426
70MP0005451_abnormal_body_composition1.03744135
71MP0000703_abnormal_thymus_morphology1.02761556
72MP0002277_abnormal_respiratory_mucosa1.02609332
73MP0004883_abnormal_blood_vessel1.02384741
74MP0005174_abnormal_tail_pigmentation1.01347628
75MP0001851_eye_inflammation1.01042052
76MP0010307_abnormal_tumor_latency0.97319153
77MP0003453_abnormal_keratinocyte_physiol0.96913766
78MP0005390_skeleton_phenotype0.95952553
79MP0008438_abnormal_cutaneous_collagen0.95273083
80MP0003045_fibrosis0.91440924
81MP0003690_abnormal_glial_cell0.90993044
82MP0001958_emphysema0.89842259
83MP0002019_abnormal_tumor_incidence0.89760334
84MP0005166_decreased_susceptibility_to0.89177297
85MP0002254_reproductive_system_inflammat0.88921875
86MP0000569_abnormal_digit_pigmentation0.87148010
87MP0009763_increased_sensitivity_to0.85904805
88MP0003075_altered_response_to0.85376465
89MP0002132_abnormal_respiratory_system0.85214401
90MP0004782_abnormal_surfactant_physiolog0.82553997
91MP0000249_abnormal_blood_vessel0.81758778
92MP0005167_abnormal_blood-brain_barrier0.80838035
93MP0005075_abnormal_melanosome_morpholog0.80592023
94MP0005164_abnormal_response_to0.80399735
95MP0003279_aneurysm0.79638960
96MP0002136_abnormal_kidney_physiology0.77934053
97MP0008260_abnormal_autophagy0.77185356
98MP0001542_abnormal_bone_strength0.76948528
99MP0003183_abnormal_peptide_metabolism0.76699991
100MP0009765_abnormal_xenobiotic_induced0.76232290
101MP0006054_spinal_hemorrhage0.75395822
102MP0003795_abnormal_bone_structure0.73091171
103MP0002877_abnormal_melanocyte_morpholog0.72802541
104MP0005076_abnormal_cell_differentiation0.69550049
105MP0005165_increased_susceptibility_to0.68149676
106MP0003656_abnormal_erythrocyte_physiolo0.66976403
107MP0003091_abnormal_cell_migration0.63442338
108MP0001663_abnormal_digestive_system0.63207515
109MP0001216_abnormal_epidermal_layer0.61409457
110MP0001243_abnormal_dermal_layer0.60818665
111MP0000371_diluted_coat_color0.58284348
112MP0001765_abnormal_ion_homeostasis0.57290200
113MP0002009_preneoplasia0.57045302
114MP0000015_abnormal_ear_pigmentation0.57007933
115MP0002693_abnormal_pancreas_physiology0.55593084
116MP0008874_decreased_physiological_sensi0.55167958
117MP0005319_abnormal_enzyme/_coenzyme0.53925808
118MP0003252_abnormal_bile_duct0.52084431
119MP0000609_abnormal_liver_physiology0.51300530

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.29790816
2Recurrent abscess formation (HP:0002722)6.06992173
3Recurrent bacterial skin infections (HP:0005406)5.40942323
4Abnormality of macrophages (HP:0004311)4.61357453
5Recurrent gram-negative bacterial infections (HP:0005420)4.41778392
6Elevated erythrocyte sedimentation rate (HP:0003565)4.41592699
7Myositis (HP:0100614)4.33314008
8Vacuolated lymphocytes (HP:0001922)4.05134555
9Recurrent fungal infections (HP:0002841)3.94685204
10Obstructive lung disease (HP:0006536)3.79415363
11Chronic obstructive pulmonary disease (HP:0006510)3.79415363
12Mediastinal lymphadenopathy (HP:0100721)3.70513545
13Recurrent skin infections (HP:0001581)3.61693280
14Orchitis (HP:0100796)3.56568293
15Gingivitis (HP:0000230)3.23272554
16Cellulitis (HP:0100658)3.21677372
17Pustule (HP:0200039)3.21580127
18Recurrent viral infections (HP:0004429)3.21445253
19Autoimmune thrombocytopenia (HP:0001973)3.20245404
20Autoimmune hemolytic anemia (HP:0001890)3.18044034
21Petechiae (HP:0000967)3.15929798
22Retrobulbar optic neuritis (HP:0100654)3.14343611
23Optic neuritis (HP:0100653)3.14343611
24Vasculitis (HP:0002633)3.08223970
25Stomatitis (HP:0010280)3.07863849
26IgM deficiency (HP:0002850)2.97271979
27Meningitis (HP:0001287)2.96766356
28Chronic otitis media (HP:0000389)2.85944012
29Interstitial pulmonary disease (HP:0006530)2.85781644
30Chest pain (HP:0100749)2.84906144
31Keratoconjunctivitis (HP:0001096)2.84899653
32Recurrent cutaneous fungal infections (HP:0011370)2.84569468
33Chronic mucocutaneous candidiasis (HP:0002728)2.84569468
34Urticaria (HP:0001025)2.74168471
35Spontaneous hematomas (HP:0007420)2.72137635
36Thrombocytosis (HP:0001894)2.72029521
37Increased cerebral lipofuscin (HP:0011813)2.70832717
38Systemic lupus erythematosus (HP:0002725)2.69598229
39Gangrene (HP:0100758)2.62677486
40Pulmonary embolism (HP:0002204)2.62203236
41Leukocytosis (HP:0001974)2.61848692
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.60931056
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60912031
44Severe combined immunodeficiency (HP:0004430)2.57556524
45Joint swelling (HP:0001386)2.55725179
46Abnormality of T cell physiology (HP:0011840)2.53465406
47Eosinophilia (HP:0001880)2.52558748
48Abnormality of T cells (HP:0002843)2.52051908
49Osteomyelitis (HP:0002754)2.51759730
50Abnormality of the nasal mucosa (HP:0000433)2.50475023
51Abnormality of T cell number (HP:0011839)2.49583107
52Pulmonary infiltrates (HP:0002113)2.49164907
53Recurrent bronchitis (HP:0002837)2.48220300
54Nasal polyposis (HP:0100582)2.47830394
55Hypergammaglobulinemia (HP:0010702)2.45931969
56Basal ganglia calcification (HP:0002135)2.45246794
57Chronic diarrhea (HP:0002028)2.45091391
58Increased IgE level (HP:0003212)2.43606249
59Axonal loss (HP:0003447)2.43002676
60Hemoptysis (HP:0002105)2.41931372
61Dysostosis multiplex (HP:0000943)2.41267573
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.40975370
63Increased IgM level (HP:0003496)2.40288178
64Recurrent pneumonia (HP:0006532)2.38103093
65Granulocytopenia (HP:0001913)2.37815961
66Abnormality of glycolipid metabolism (HP:0010969)2.37801588
67Abnormality of liposaccharide metabolism (HP:0010968)2.37801588
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.37801588
69T lymphocytopenia (HP:0005403)2.35538697
70Periodontitis (HP:0000704)2.34671648
71Hematochezia (HP:0002573)2.31451056
72Arterial thrombosis (HP:0004420)2.31393441
73Episodic fever (HP:0001954)2.29481929
74Inflammation of the large intestine (HP:0002037)2.28614716
75Abnormality of the pleura (HP:0002103)2.27973473
76Vertebral compression fractures (HP:0002953)2.27356134
77Skin ulcer (HP:0200042)2.27236769
78Combined immunodeficiency (HP:0005387)2.26296721
79Hepatosplenomegaly (HP:0001433)2.25718925
80Epistaxis (HP:0000421)2.25100015
81Panhypogammaglobulinemia (HP:0003139)2.24553282
82Recurrent lower respiratory tract infections (HP:0002783)2.24098717
83Gingival bleeding (HP:0000225)2.23431932
84Prostate neoplasm (HP:0100787)2.22841175
85Abnormal platelet volume (HP:0011876)2.21622385
86Abnormality of eosinophils (HP:0001879)2.21479662
87Amyloidosis (HP:0011034)2.19419346
88Prolonged bleeding time (HP:0003010)2.19077456
89Glomerulopathy (HP:0100820)2.18306780
90Gastrointestinal inflammation (HP:0004386)2.17515760
91Abnormality of the prostate (HP:0008775)2.17297009
92Osteolytic defects of the phalanges of the hand (HP:0009771)2.16074195
93Osteolytic defects of the hand bones (HP:0009699)2.16074195
94Purpura (HP:0000979)2.14566735
95Polyneuropathy (HP:0001271)2.12476718
96Myocardial infarction (HP:0001658)2.12017554
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.11989646
98Lymphopenia (HP:0001888)2.11602126
99Poor head control (HP:0002421)2.10114662
100Cheilitis (HP:0100825)2.09241072
101Encephalitis (HP:0002383)2.09182228
102Abnormality of iron homeostasis (HP:0011031)2.08310691
103Keratoconjunctivitis sicca (HP:0001097)2.06155322
104Vertigo (HP:0002321)2.04415127
105Acute hepatic failure (HP:0006554)2.03274131
106Gastrointestinal infarctions (HP:0005244)2.02937168
107Agnosia (HP:0010524)2.02594598
108Skin rash (HP:0000988)2.02516210
109Pulmonary fibrosis (HP:0002206)2.01760961
110Peritonitis (HP:0002586)2.01595007
111Thyroiditis (HP:0100646)2.01442042
112Increased serum ferritin (HP:0003281)2.00943420
113Anorexia (HP:0002039)2.00742347
114Colitis (HP:0002583)2.00096366
115Abnormality of the pericardium (HP:0001697)1.99840375
116Arthralgia (HP:0002829)1.99459560
117Abnormality of B cell number (HP:0010975)1.97057836
118Hypochromic anemia (HP:0001931)1.96844875
119Sepsis (HP:0100806)1.96822569
120Gastrointestinal stroma tumor (HP:0100723)1.95802072
121IgG deficiency (HP:0004315)1.95491732
122Mucopolysacchariduria (HP:0008155)1.95332823
123Urinary glycosaminoglycan excretion (HP:0003541)1.95332823
124Abnormal platelet function (HP:0011869)1.94818341
125Impaired platelet aggregation (HP:0003540)1.94818341
126Agammaglobulinemia (HP:0004432)1.94222316
127Menorrhagia (HP:0000132)1.93143467
128Reduced antithrombin III activity (HP:0001976)1.92835665

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.65795731
2MAP4K13.13849141
3MAP3K142.97412365
4IRAK42.90169572
5TBK12.76587232
6NME22.72039705
7TYK22.64838577
8PIM22.63525523
9IRAK32.47144062
10TXK2.29121912
11JAK32.19483885
12ERN12.12198687
13IKBKE2.08229094
14KIT2.07630391
15ZAP702.07190244
16IKBKB1.99960961
17TEC1.98187307
18BMPR21.93089650
19STK101.79765488
20TESK21.74802496
21NEK91.74599181
22BTK1.72360613
23KDR1.66437129
24RIPK41.66298706
25CSK1.64818324
26JAK11.55737917
27MST41.54420776
28RPS6KA41.51308991
29PIM11.47920816
30TNK21.46577002
31MAP2K31.43149929
32TGFBR21.42298756
33LRRK21.40571339
34SYK1.31677267
35EPHB11.31359964
36CSF1R1.30656297
37ITK1.29313859
38GRK71.26284153
39HCK1.16260247
40LCK1.13095115
41PBK1.10690729
42GRK61.10598937
43MAP3K111.07146285
44TESK11.06149565
45TAOK31.05243281
46TRPM71.03853294
47LYN1.01948314
48CHUK1.01244245
49PRPF4B1.00891629
50MATK0.99590133
51SIK30.98076948
52NLK0.95250140
53FGFR40.94913879
54PRKCQ0.90021445
55EIF2AK10.85605806
56EPHA30.84715264
57MAP3K30.84425702
58MAP3K10.84144526
59MAPKAPK30.83952024
60MAP3K130.83808174
61FLT30.81298575
62EIF2AK30.80919029
63PDK10.80536251
64TAOK10.80243119
65MARK30.78916826
66TAOK20.77624383
67STK40.77476514
68TLK10.74178341
69CLK10.73823959
70FES0.73129333
71EIF2AK20.72164571
72JAK20.70635122
73FGFR30.70299380
74GRK50.70030286
75PAK40.69861131
76SCYL20.69468360
77FYN0.66579863
78TRIB30.65791226
79ABL20.65321238
80MAP3K120.64175869
81CAMKK20.63930593
82MAPKAPK20.63705874
83PTK2B0.61267889
84IRAK10.61247969
85MAP3K80.60139144
86ACVR1B0.59478686
87ARAF0.57247136
88MYLK0.55670912
89STK160.54616203
90PRKCD0.53476171
91PDPK10.51139983
92PRKG20.50225955
93BUB10.49143614
94EPHA20.48885202
95RPS6KB20.47638592
96RPS6KA60.46639435
97PIK3CG0.46597167
98ABL10.46476511
99MOS0.46420351
100MAP2K60.46419411
101FGR0.44137815
102MAP3K100.43687785
103STK240.43389635
104RPS6KA50.41450383
105ADRBK20.40994954
106KSR20.40575022
107MAP2K20.40471917
108NEK20.39324586
109BMX0.37894139
110TTN0.37737442
111MAPK120.37145371
112IRAK20.37078460
113MAP3K50.35524154
114RPS6KL10.34195698
115RPS6KC10.34195698
116PRKD20.33682373
117IGF1R0.33634190
118TGFBR10.33615096
119PRKD10.33267663
120CDK40.32533486
121MAPK40.32214986
122CDK60.31791371
123YES10.31270433
124LIMK10.30874966
125HIPK20.30327180
126EGFR0.30094674
127DAPK10.28980228
128MAP3K20.27960993
129FER0.27686607
130DAPK20.24645794
131INSR0.24396709
132PAK10.20677963
133MAPK70.20491164
134ADRBK10.20304016
135NUAK10.18597541

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.94650951
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.43486054
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31287649
4Graft-versus-host disease_Homo sapiens_hsa053322.25430676
5Primary immunodeficiency_Homo sapiens_hsa053402.22569781
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16658839
7Osteoclast differentiation_Homo sapiens_hsa043802.11844953
8Staphylococcus aureus infection_Homo sapiens_hsa051502.08977777
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.08539540
10Measles_Homo sapiens_hsa051622.07971105
11Legionellosis_Homo sapiens_hsa051342.02750028
12Antigen processing and presentation_Homo sapiens_hsa046122.01540295
13Ribosome_Homo sapiens_hsa030101.96654302
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.95198672
15Other glycan degradation_Homo sapiens_hsa005111.94186125
16Allograft rejection_Homo sapiens_hsa053301.91952071
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84429754
18Hematopoietic cell lineage_Homo sapiens_hsa046401.82487715
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81778190
20Pertussis_Homo sapiens_hsa051331.76167406
21Malaria_Homo sapiens_hsa051441.73741078
22Proteasome_Homo sapiens_hsa030501.69550574
23Shigellosis_Homo sapiens_hsa051311.66885564
24Tuberculosis_Homo sapiens_hsa051521.65794029
25B cell receptor signaling pathway_Homo sapiens_hsa046621.62895988
26Lysosome_Homo sapiens_hsa041421.61945323
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60051925
28Apoptosis_Homo sapiens_hsa042101.55706901
29Toxoplasmosis_Homo sapiens_hsa051451.52086462
30Herpes simplex infection_Homo sapiens_hsa051681.49396366
31Asthma_Homo sapiens_hsa053101.48610360
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.47451495
33Influenza A_Homo sapiens_hsa051641.43660935
34Salmonella infection_Homo sapiens_hsa051321.42864492
35TNF signaling pathway_Homo sapiens_hsa046681.42720525
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39646874
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.36167857
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34197508
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32988095
40Rheumatoid arthritis_Homo sapiens_hsa053231.30761734
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.25987133
42DNA replication_Homo sapiens_hsa030301.24798848
43Phagosome_Homo sapiens_hsa041451.22060813
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16198634
45Viral myocarditis_Homo sapiens_hsa054161.14835668
46Chemokine signaling pathway_Homo sapiens_hsa040621.10264678
47p53 signaling pathway_Homo sapiens_hsa041151.07641985
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07176439
49Hepatitis B_Homo sapiens_hsa051611.04996038
50Autoimmune thyroid disease_Homo sapiens_hsa053201.04139416
51T cell receptor signaling pathway_Homo sapiens_hsa046601.03835967
52Acute myeloid leukemia_Homo sapiens_hsa052211.01621046
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00287567
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99966946
55Epstein-Barr virus infection_Homo sapiens_hsa051690.99796106
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99622567
57Base excision repair_Homo sapiens_hsa034100.91748946
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90388697
59Hepatitis C_Homo sapiens_hsa051600.87809987
60Pentose phosphate pathway_Homo sapiens_hsa000300.84690103
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83098193
62Platelet activation_Homo sapiens_hsa046110.70627909
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69909434
64Homologous recombination_Homo sapiens_hsa034400.69394197
65Viral carcinogenesis_Homo sapiens_hsa052030.68558356
66Small cell lung cancer_Homo sapiens_hsa052220.67710703
67Caffeine metabolism_Homo sapiens_hsa002320.67549273
68Collecting duct acid secretion_Homo sapiens_hsa049660.67063060
69Pancreatic cancer_Homo sapiens_hsa052120.66317167
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65574704
71Chronic myeloid leukemia_Homo sapiens_hsa052200.64949873
72Mismatch repair_Homo sapiens_hsa034300.61552359
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60170567
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59350549
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57394071
76Folate biosynthesis_Homo sapiens_hsa007900.56987407
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56667416
78Renin-angiotensin system_Homo sapiens_hsa046140.55424365
79Type I diabetes mellitus_Homo sapiens_hsa049400.52675102
80HTLV-I infection_Homo sapiens_hsa051660.51481500
81Non-small cell lung cancer_Homo sapiens_hsa052230.51183439
82Amoebiasis_Homo sapiens_hsa051460.49953939
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48519547
84Pyrimidine metabolism_Homo sapiens_hsa002400.48060270
85HIF-1 signaling pathway_Homo sapiens_hsa040660.47992754
86Endocytosis_Homo sapiens_hsa041440.46987041
87African trypanosomiasis_Homo sapiens_hsa051430.45275308
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43727588
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42557589
90Sphingolipid metabolism_Homo sapiens_hsa006000.40755443
91Nucleotide excision repair_Homo sapiens_hsa034200.36964185
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.36764768
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.35832028
94VEGF signaling pathway_Homo sapiens_hsa043700.35758027
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35718096
96Regulation of autophagy_Homo sapiens_hsa041400.35580472
97Sulfur relay system_Homo sapiens_hsa041220.35235532
98Arachidonic acid metabolism_Homo sapiens_hsa005900.34485395
99Prolactin signaling pathway_Homo sapiens_hsa049170.34460980
100Protein export_Homo sapiens_hsa030600.33571534
101Systemic lupus erythematosus_Homo sapiens_hsa053220.33093968
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32831865
103Complement and coagulation cascades_Homo sapiens_hsa046100.32480198
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.32014884
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28167130
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27283700
107Dorso-ventral axis formation_Homo sapiens_hsa043200.22757605
108Sulfur metabolism_Homo sapiens_hsa009200.22757182
109Renal cell carcinoma_Homo sapiens_hsa052110.18350177
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.18310862
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.16786247
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14537625
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12250352
114MAPK signaling pathway_Homo sapiens_hsa040100.10934210
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10677482
116Insulin resistance_Homo sapiens_hsa049310.09022446
117Galactose metabolism_Homo sapiens_hsa000520.08676110

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