OSMR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.18780472
2protein heterotrimerization (GO:0070208)4.86800707
3sequestering of extracellular ligand from receptor (GO:0035581)4.58327332
4retina vasculature morphogenesis in camera-type eye (GO:0061299)4.47514828
5chondrocyte proliferation (GO:0035988)4.36823588
6Golgi transport vesicle coating (GO:0048200)4.26921653
7COPI coating of Golgi vesicle (GO:0048205)4.26921653
8vascular endothelial growth factor signaling pathway (GO:0038084)4.26904772
9skin morphogenesis (GO:0043589)4.22950776
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.11793866
11hemidesmosome assembly (GO:0031581)4.09535696
12lymph vessel development (GO:0001945)4.02648809
13cell adhesion mediated by integrin (GO:0033627)3.97669437
14metanephric mesenchyme development (GO:0072075)3.93005449
15endodermal cell differentiation (GO:0035987)3.90393642
16mesenchymal-epithelial cell signaling (GO:0060638)3.84422723
17positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.80625847
18protein retention in ER lumen (GO:0006621)3.76743960
19wound healing, spreading of epidermal cells (GO:0035313)3.76475762
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.73809296
21axon extension involved in axon guidance (GO:0048846)3.73809296
22regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.72984151
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.69073778
24bone trabecula formation (GO:0060346)3.68583086
25surfactant homeostasis (GO:0043129)3.67044771
26protein hydroxylation (GO:0018126)3.63810619
27endothelial cell morphogenesis (GO:0001886)3.58595847
28regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.57654776
29positive regulation of osteoblast proliferation (GO:0033690)3.50625908
30kidney mesenchyme development (GO:0072074)3.49952577
31regulation of transforming growth factor beta2 production (GO:0032909)3.49729930
32collagen metabolic process (GO:0032963)3.48228555
33lung vasculature development (GO:0060426)3.46274052
34lymphangiogenesis (GO:0001946)3.45796160
35type B pancreatic cell proliferation (GO:0044342)3.45171390
36hypotonic response (GO:0006971)3.42739644
37basement membrane organization (GO:0071711)3.41334567
38collagen catabolic process (GO:0030574)3.36007110
39multicellular organismal macromolecule metabolic process (GO:0044259)3.30003228
40cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.28171065
41interleukin-6-mediated signaling pathway (GO:0070102)3.27645541
42extracellular matrix assembly (GO:0085029)3.21723577
43extracellular matrix disassembly (GO:0022617)3.16196923
44cell migration involved in sprouting angiogenesis (GO:0002042)3.15854580
45dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.14725134
46positive regulation of extracellular matrix organization (GO:1903055)3.13510576
47multicellular organismal metabolic process (GO:0044236)3.13416096
48multicellular organismal catabolic process (GO:0044243)3.09574519
49cell-substrate adherens junction assembly (GO:0007045)3.07250123
50focal adhesion assembly (GO:0048041)3.07250123
51artery development (GO:0060840)3.07165963
52positive regulation of endothelial cell apoptotic process (GO:2000353)3.06334798
53glomerular filtration (GO:0003094)3.05297508
54smooth muscle tissue development (GO:0048745)3.05167858
55regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03603530
56glomerular basement membrane development (GO:0032836)3.03312453
57blood vessel maturation (GO:0001955)3.01380092
58renal filtration (GO:0097205)3.00954666
59regulation of plasminogen activation (GO:0010755)3.00033362
60COPII vesicle coating (GO:0048208)2.98936276
61wound healing, spreading of cells (GO:0044319)2.98576520
62dermatan sulfate biosynthetic process (GO:0030208)2.98544677
63protein localization to endosome (GO:0036010)2.97057379
64negative regulation of fatty acid transport (GO:2000192)2.94304890
65adherens junction assembly (GO:0034333)2.89288023
66regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.88398474
67growth hormone receptor signaling pathway (GO:0060396)2.88093693
68apoptotic cell clearance (GO:0043277)2.87886548
69cellular response to vitamin (GO:0071295)2.86679738
70extracellular matrix organization (GO:0030198)2.84923341
71radial glial cell differentiation (GO:0060019)2.84112580
72extracellular structure organization (GO:0043062)2.83870008
73muscle cell migration (GO:0014812)2.83006417
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.80250787
75hippo signaling (GO:0035329)2.80076837
76positive regulation of p38MAPK cascade (GO:1900745)2.79191386
77epithelial cell-cell adhesion (GO:0090136)2.78787802
78negative regulation of fibrinolysis (GO:0051918)2.78490182
79endocardial cushion development (GO:0003197)2.78403305
80regulation of tight junction assembly (GO:2000810)2.78076736
81plasma membrane repair (GO:0001778)2.77569207
82polarized epithelial cell differentiation (GO:0030859)2.76735730
83peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.76392745
84substrate-dependent cell migration (GO:0006929)2.74119220
85extracellular fibril organization (GO:0043206)2.73811866
86cell-substrate junction assembly (GO:0007044)2.72361940
87protein localization to cell surface (GO:0034394)2.72124987
88atrioventricular valve morphogenesis (GO:0003181)2.72041272
89dermatan sulfate metabolic process (GO:0030205)2.71005397
90hyaluronan catabolic process (GO:0030214)2.70761652
91negative regulation of complement activation (GO:0045916)2.70413596
92regulation of extracellular matrix disassembly (GO:0010715)2.70394171
93branching involved in salivary gland morphogenesis (GO:0060445)2.70224658
94positive regulation of astrocyte differentiation (GO:0048711)2.69202017
95chemical homeostasis within a tissue (GO:0048875)2.68013585
96negative regulation of chondrocyte differentiation (GO:0032331)2.67767458
97response to fluid shear stress (GO:0034405)2.66874776
98negative regulation of protein activation cascade (GO:2000258)2.66718367
99regulation of apoptotic cell clearance (GO:2000425)2.66666684
100regulation of integrin-mediated signaling pathway (GO:2001044)2.66531293
101bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66394256
102membrane protein ectodomain proteolysis (GO:0006509)2.65686792
103pericardium development (GO:0060039)2.62726378
104negative regulation of leukocyte chemotaxis (GO:0002689)2.61589561
105desmosome organization (GO:0002934)2.60901397
106peptidyl-proline hydroxylation (GO:0019511)2.60575532
107mesodermal cell differentiation (GO:0048333)2.60366932
108substrate adhesion-dependent cell spreading (GO:0034446)2.60051517
109planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60042785
110vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.59514452
111blood vessel endothelial cell migration (GO:0043534)2.59294435
112protein carboxylation (GO:0018214)2.58448058
113peptidyl-glutamic acid carboxylation (GO:0017187)2.58448058
114fibril organization (GO:0097435)2.56238015
115negative regulation of smooth muscle cell migration (GO:0014912)2.55526211
116activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54600304
117positive regulation of mesenchymal cell proliferation (GO:0002053)2.53544786
118face morphogenesis (GO:0060325)2.52912286
119cellular response to vitamin D (GO:0071305)2.52728813
120regulation of endothelial cell differentiation (GO:0045601)2.52357521
121vesicle coating (GO:0006901)2.52329700
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50414896
123cell-matrix adhesion (GO:0007160)2.50010080
124venous blood vessel morphogenesis (GO:0048845)2.49709482
125keratinocyte proliferation (GO:0043616)2.48970284
126negative regulation of keratinocyte proliferation (GO:0010839)2.48949616
127negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.48893116
128keratan sulfate catabolic process (GO:0042340)2.48205454
129wound healing (GO:0042060)2.48157049
130cardiac epithelial to mesenchymal transition (GO:0060317)2.47621694
131extracellular regulation of signal transduction (GO:1900115)2.47239097
132extracellular negative regulation of signal transduction (GO:1900116)2.47239097
133cell migration involved in heart development (GO:0060973)2.46980181
134iron ion import (GO:0097286)2.46475592
135trabecula formation (GO:0060343)2.46283490
136endothelial cell proliferation (GO:0001935)2.45909686
137chondrocyte development (GO:0002063)2.45666463
138regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45526175
139cellular response to growth hormone stimulus (GO:0071378)2.45387565
140cellular response to interferon-alpha (GO:0035457)2.44826074
141heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.44812010
142ovulation from ovarian follicle (GO:0001542)2.44410523
143positive regulation of epithelial to mesenchymal transition (GO:0010718)2.44321262
144adhesion of symbiont to host (GO:0044406)2.43420108
145positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42910359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.19365172
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.14760580
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32566659
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.84389796
5ZNF263_19887448_ChIP-Seq_K562_Human2.55445493
6CJUN_26792858_Chip-Seq_BT549_Human2.46897926
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46723178
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.45578809
9CLOCK_20551151_ChIP-Seq_293T_Human2.39462557
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.38076507
11* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.34198736
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.29615299
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.26567285
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.24249767
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.13101030
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11550945
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01093853
18* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.96677509
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96601647
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96548685
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95204754
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94171375
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93761094
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.92450957
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.91974849
26* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.83355543
27* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.83355543
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80594313
29TP53_18474530_ChIP-ChIP_U2OS_Human1.79038750
30* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74228104
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73186625
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.73149681
33* BRD4_25478319_ChIP-Seq_HGPS_Human1.69429399
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68241721
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68021746
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68021746
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63615045
38AR_21909140_ChIP-Seq_LNCAP_Human1.62809584
39ATF3_27146783_Chip-Seq_COLON_Human1.57594454
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57045530
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54661002
42TP53_16413492_ChIP-PET_HCT116_Human1.53166294
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.52800560
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.52596899
45SOX2_20726797_ChIP-Seq_SW620_Human1.50878790
46* EED_16625203_ChIP-ChIP_MESCs_Mouse1.48607912
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45606584
48TP53_22127205_ChIP-Seq_IMR90_Human1.44832830
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.44606994
50* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41992805
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41108563
52AHR_22903824_ChIP-Seq_MCF-7_Human1.38206852
53RACK7_27058665_Chip-Seq_MCF-7_Human1.37515456
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36440956
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35598022
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.33478591
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32768732
58JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31815419
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31289151
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31289151
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31147648
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30646363
63AR_21572438_ChIP-Seq_LNCaP_Human1.30323992
64* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29934308
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.29084299
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27737751
67* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26037478
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.25707248
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25507360
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22756624
71EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22624190
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22159998
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20970662
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.20792012
75RXR_22108803_ChIP-Seq_LS180_Human1.19745487
76* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19540770
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16293500
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.15150239
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.15150239
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.11507620
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11048698
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10109675
83* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08520984
84TP63_23658742_ChIP-Seq_EP156T_Human1.08256450
85* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07197572
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06710561
87* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06458800
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.06351049
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06119157
90BCAT_22108803_ChIP-Seq_LS180_Human1.05860778
91* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03616771
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03467214
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.02674427
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02393920
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01921055
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01910531
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01859987
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.01266573
99PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00056106
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99653294
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99621377
102* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98910840
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98906302
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98824194
105EGR1_19374776_ChIP-ChIP_THP-1_Human0.98492139
106* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97799698
107PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97543794
108JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97263536
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97176213
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96631214
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96107555
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95956581
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94518427
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94120645
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94120445
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94055823
117GBX2_23144817_ChIP-Seq_PC3_Human0.93839102
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.92998501
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92311280
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92173304
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91676279
122RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91170564
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.91033998
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90482302
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89375214
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89068563
127VDR_24787735_ChIP-Seq_THP-1_Human0.88733582
128KDM2B_26808549_Chip-Seq_K562_Human0.88511506
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.88037863
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87837670
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87786356
132SALL1_21062744_ChIP-ChIP_HESCs_Human0.87653912
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86975332
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86021817
135* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84561425
136* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84352342
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84146770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.52262941
2MP0005275_abnormal_skin_tensile5.38573601
3MP0005503_abnormal_tendon_morphology4.78358307
4MP0003279_aneurysm3.72978112
5MP0003705_abnormal_hypodermis_morpholog3.71966574
6MP0001958_emphysema3.42486842
7MP0004272_abnormal_basement_membrane3.32857138
8MP0009384_cardiac_valve_regurgitation2.76861165
9MP0010368_abnormal_lymphatic_system2.49326223
10MP0003566_abnormal_cell_adhesion2.31757289
11MP0002060_abnormal_skin_morphology2.28456420
12MP0006054_spinal_hemorrhage2.17652435
13MP0001879_abnormal_lymphatic_vessel2.14022996
14MP0005623_abnormal_meninges_morphology2.03080342
15MP0005023_abnormal_wound_healing1.99218800
16MP0005508_abnormal_skeleton_morphology1.98943145
17MP0002295_abnormal_pulmonary_circulatio1.93480050
18MP0003045_fibrosis1.85428520
19MP0003724_increased_susceptibility_to1.78218841
20MP0002108_abnormal_muscle_morphology1.76375787
21MP0003091_abnormal_cell_migration1.65180196
22MP0005257_abnormal_intraocular_pressure1.64400618
23MP0005409_darkened_coat_color1.62560857
24MP0000767_abnormal_smooth_muscle1.52772511
25MP0010352_gastrointestinal_tract_polyps1.52755948
26MP0003300_gastrointestinal_ulcer1.49710545
27MP0003950_abnormal_plasma_membrane1.49346999
28MP0002896_abnormal_bone_mineralization1.47965415
29MP0002254_reproductive_system_inflammat1.43727760
30MP0001849_ear_inflammation1.42194123
31MP0004858_abnormal_nervous_system1.41584552
32MP0003941_abnormal_skin_development1.39032190
33MP0001542_abnormal_bone_strength1.37009173
34MP0000733_abnormal_muscle_development1.36914572
35MP0002933_joint_inflammation1.35082319
36MP0009250_abnormal_appendicular_skeleto1.34785472
37MP0005171_absent_coat_pigmentation1.30940984
38MP0002168_other_aberrant_phenotype1.28741104
39MP0000013_abnormal_adipose_tissue1.26347776
40MP0010030_abnormal_orbit_morphology1.26049794
41MP0001348_abnormal_lacrimal_gland1.24305678
42MP0005390_skeleton_phenotype1.23637172
43MP0001299_abnormal_eye_distance/1.23130596
44MP0000467_abnormal_esophagus_morphology1.22671410
45MP0003283_abnormal_digestive_organ1.22469099
46MP0001243_abnormal_dermal_layer1.21326961
47MP0003385_abnormal_body_wall1.18095936
48MP0010234_abnormal_vibrissa_follicle1.16882977
49MP0000751_myopathy1.15664439
50MP0004233_abnormal_muscle_weight1.13805791
51MP0000750_abnormal_muscle_regeneration1.12401943
52MP0003828_pulmonary_edema1.11546943
53MP0002282_abnormal_trachea_morphology1.11274778
54MP0001661_extended_life_span1.09957315
55MP0001915_intracranial_hemorrhage1.09776026
56MP0008004_abnormal_stomach_pH1.07365365
57MP0003191_abnormal_cellular_cholesterol1.06783355
58MP0005164_abnormal_response_to1.06044055
59MP0000163_abnormal_cartilage_morphology1.04787451
60MP0005595_abnormal_vascular_smooth1.01402265
61MP0004782_abnormal_surfactant_physiolog1.00981959
62MP0005165_increased_susceptibility_to1.00550522
63MP0009840_abnormal_foam_cell1.00298900
64MP0005197_abnormal_uvea_morphology0.99899303
65MP0000343_altered_response_to0.99859776
66MP0002133_abnormal_respiratory_system0.99394525
67MP0005388_respiratory_system_phenotype0.99394525
68MP0002998_abnormal_bone_remodeling0.99335844
69MP0008775_abnormal_heart_ventricle0.98244537
70MP0001216_abnormal_epidermal_layer0.96966575
71MP0002115_abnormal_skeleton_extremities0.96679503
72MP0001533_abnormal_skeleton_physiology0.94768160
73MP0000762_abnormal_tongue_morphology0.94352945
74MP0005501_abnormal_skin_physiology0.90907643
75MP0004484_altered_response_of0.89710321
76MP0003453_abnormal_keratinocyte_physiol0.89608770
77MP0009278_abnormal_bone_marrow0.89217586
78MP0000003_abnormal_adipose_tissue0.88890560
79MP0002128_abnormal_blood_circulation0.88631539
80MP0000858_altered_metastatic_potential0.87627639
81MP0002877_abnormal_melanocyte_morpholog0.86884555
82MP0004134_abnormal_chest_morphology0.85603077
83MP0002113_abnormal_skeleton_development0.85431653
84MP0009780_abnormal_chondrocyte_physiolo0.84822167
85MP0001346_abnormal_lacrimal_gland0.84314306
86MP0004084_abnormal_cardiac_muscle0.84105128
87MP0002089_abnormal_postnatal_growth/wei0.83930702
88MP0004883_abnormal_blood_vessel0.83393572
89MP0001177_atelectasis0.82306493
90MP0000462_abnormal_digestive_system0.82053861
91MP0000534_abnormal_ureter_morphology0.81099982
92MP0010771_integument_phenotype0.80984366
93MP0001614_abnormal_blood_vessel0.80979419
94MP0003115_abnormal_respiratory_system0.80823153
95MP0005360_urolithiasis0.79665922
96MP0002932_abnormal_joint_morphology0.79514676
97MP0000579_abnormal_nail_morphology0.78543199
98MP0006138_congestive_heart_failure0.78339652
99MP0002796_impaired_skin_barrier0.78333229
100MP0003448_altered_tumor_morphology0.77406852
101MP0000383_abnormal_hair_follicle0.74461591
102MP0002925_abnormal_cardiovascular_devel0.72731882
103MP0000678_abnormal_parathyroid_gland0.72656653
104MP0003795_abnormal_bone_structure0.70998380
105MP0000516_abnormal_urinary_system0.70527448
106MP0005367_renal/urinary_system_phenotyp0.70527448
107MP0005375_adipose_tissue_phenotype0.69288099
108MP0002009_preneoplasia0.69286677
109MP0005076_abnormal_cell_differentiation0.68263186
110MP0005058_abnormal_lysosome_morphology0.67564526
111MP0001175_abnormal_lung_morphology0.67342812
112MP0003755_abnormal_palate_morphology0.67169974
113MP0010678_abnormal_skin_adnexa0.66540133
114MP0005330_cardiomyopathy0.65777042
115MP0000749_muscle_degeneration0.64523168
116MP0005670_abnormal_white_adipose0.64324204
117MP0005621_abnormal_cell_physiology0.63980346
118MP0000432_abnormal_head_morphology0.63404180
119MP0009053_abnormal_anal_canal0.63394631
120MP0005193_abnormal_anterior_eye0.62927034
121MP0003942_abnormal_urinary_system0.62313743
122MP0004087_abnormal_muscle_fiber0.62066126
123MP0000759_abnormal_skeletal_muscle0.61587594
124MP0005451_abnormal_body_composition0.61489754
125MP0000627_abnormal_mammary_gland0.61241523
126MP0000428_abnormal_craniofacial_morphol0.61005333
127MP0000537_abnormal_urethra_morphology0.59514453

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.62736300
2Premature rupture of membranes (HP:0001788)7.29714122
3Broad metatarsal (HP:0001783)5.16650021
4Atrophic scars (HP:0001075)5.15584573
5Aortic dissection (HP:0002647)4.77239194
6Aortic aneurysm (HP:0004942)4.52531840
7Shallow orbits (HP:0000586)4.47600816
8Ankle contracture (HP:0006466)4.32254909
9Fragile skin (HP:0001030)3.91731886
10Peritonitis (HP:0002586)3.88716641
11Soft skin (HP:0000977)3.87905514
12Follicular hyperkeratosis (HP:0007502)3.86685261
13Cerebral aneurysm (HP:0004944)3.55498650
14Spinal rigidity (HP:0003306)3.52395324
15Dilatation of the ascending aorta (HP:0005111)3.51921095
16Cervical subluxation (HP:0003308)3.47879605
17Increased connective tissue (HP:0009025)3.47753658
18Bladder diverticulum (HP:0000015)3.37655703
19Wrist flexion contracture (HP:0001239)3.34617604
20Vertebral compression fractures (HP:0002953)3.24470364
21Vascular tortuosity (HP:0004948)3.18655434
22Abnormality of dentin (HP:0010299)3.17209432
23Type 1 muscle fiber predominance (HP:0003803)3.12937502
24Neonatal short-limb short stature (HP:0008921)3.10979596
25Wormian bones (HP:0002645)3.03091518
26Mitral valve prolapse (HP:0001634)3.02791289
27Genu recurvatum (HP:0002816)3.00995886
28Blue sclerae (HP:0000592)2.85699320
29Round ear (HP:0100830)2.81749238
30Overgrowth (HP:0001548)2.79484724
31Arterial tortuosity (HP:0005116)2.72210488
32Biconcave vertebral bodies (HP:0004586)2.70707149
33Abnormality of the ischium (HP:0003174)2.64929258
34Right ventricular cardiomyopathy (HP:0011663)2.59771660
35Aneurysm (HP:0002617)2.55510514
36Hyperextensible skin (HP:0000974)2.50886453
37Natal tooth (HP:0000695)2.48587510
38Alopecia of scalp (HP:0002293)2.45898021
39Abnormal delivery (HP:0001787)2.42108979
40Short nail (HP:0001799)2.40080675
41Hypoplastic ischia (HP:0003175)2.38556095
42Mildly elevated creatine phosphokinase (HP:0008180)2.38038734
43Osteolytic defects of the hand bones (HP:0009699)2.35556070
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.35556070
45Deep venous thrombosis (HP:0002625)2.34965139
46Ectopia lentis (HP:0001083)2.33187540
47Short hallux (HP:0010109)2.31389641
48Abnormality of carpal bone ossification (HP:0006257)2.29076972
49Distal lower limb amyotrophy (HP:0008944)2.28213374
50Increased variability in muscle fiber diameter (HP:0003557)2.27711460
51Hypoplasia of the iris (HP:0007676)2.26509435
52Elbow flexion contracture (HP:0002987)2.25757321
53Camptodactyly of toe (HP:0001836)2.25631662
54Abnormality of the acetabulum (HP:0003170)2.22933181
55Infantile muscular hypotonia (HP:0008947)2.21556656
56Bell-shaped thorax (HP:0001591)2.21486894
57Wide anterior fontanel (HP:0000260)2.20911180
58Bowel diverticulosis (HP:0005222)2.17720639
59Joint laxity (HP:0001388)2.17389860
60Pterygium (HP:0001059)2.16452891
61Venous abnormality (HP:0002624)2.16320850
62Aortic regurgitation (HP:0001659)2.13825928
63Muscle fiber splitting (HP:0003555)2.13360612
64Mitral stenosis (HP:0001718)2.11131990
65Aplasia/Hypoplasia of the hallux (HP:0008362)2.09792487
66Spondylolisthesis (HP:0003302)2.09464711
67Broad face (HP:0000283)2.08692137
68Abnormal ossification of hand bones (HP:0005921)2.08309997
69Osteoarthritis (HP:0002758)2.06975326
70Fragile nails (HP:0001808)2.06840888
71Thin bony cortex (HP:0002753)2.06366644
72Knee flexion contracture (HP:0006380)2.06099479
73Broad ribs (HP:0000885)2.05373445
74Venous insufficiency (HP:0005293)2.04853725
75Vascular calcification (HP:0004934)2.04344846
76Mitral regurgitation (HP:0001653)2.00473886
77Advanced eruption of teeth (HP:0006288)2.00261991
78Slender build (HP:0001533)1.99989459
79Abnormality of skeletal muscle fiber size (HP:0012084)1.98354840
80Abnormality of the anterior chamber (HP:0000593)1.97537831
81Protruding ear (HP:0000411)1.97246935
82Achilles tendon contracture (HP:0001771)1.97070972
83Cardiovascular calcification (HP:0011915)1.94843373
84Tibial bowing (HP:0002982)1.93119103
85Flat acetabular roof (HP:0003180)1.92635766
86Abnormality of the Achilles tendon (HP:0005109)1.92281544
87Pulmonary artery stenosis (HP:0004415)1.90845301
88Mesomelia (HP:0003027)1.89953785
89Distal lower limb muscle weakness (HP:0009053)1.87722854
90Small epiphyses (HP:0010585)1.87552493
91Difficulty climbing stairs (HP:0003551)1.87257156
92Abnormality of complement system (HP:0005339)1.85635258
93Ankyloglossia (HP:0010296)1.84603399
94Hyperacusis (HP:0010780)1.83941004
95Asymmetry of the thorax (HP:0001555)1.83820435
96Nonimmune hydrops fetalis (HP:0001790)1.83773669
97Tarsal synostosis (HP:0008368)1.82864701
98Coronal craniosynostosis (HP:0004440)1.82193693
99Abnormality of oral frenula (HP:0000190)1.80872322
100Bowed forearm bones (HP:0003956)1.80862440
101Bowing of the arm (HP:0006488)1.80862440
102Striae distensae (HP:0001065)1.80855686
103Syringomyelia (HP:0003396)1.80487206
104Spinal cord lesions (HP:0100561)1.80487206
105Cupped ribs (HP:0000887)1.80436721
106Limited hip movement (HP:0008800)1.79928587
107Thin skin (HP:0000963)1.79701897
108Distal upper limb amyotrophy (HP:0007149)1.79085756
109Upper limb amyotrophy (HP:0009129)1.79085756
110Scapular winging (HP:0003691)1.78988894
111Delayed closure of the anterior fontanelle (HP:0001476)1.78768289
112Buphthalmos (HP:0000557)1.78646973
113Renal duplication (HP:0000075)1.78384585
114Coxa vara (HP:0002812)1.78236264
115Thick nail (HP:0001805)1.77749480
116Ovoid vertebral bodies (HP:0003300)1.77304266
117Joint contractures involving the joints of the feet (HP:0100492)1.77143770
118Flexion contracture of toe (HP:0005830)1.77143770
119Back pain (HP:0003418)1.76787922
120Hyporeflexia of lower limbs (HP:0002600)1.76438975
121Deviation of the hallux (HP:0010051)1.76210958
122Milia (HP:0001056)1.75330144
123Lower limb amyotrophy (HP:0007210)1.75082964
124Ulnar bowing (HP:0003031)1.74973808
125Generalized amyotrophy (HP:0003700)1.72116611
126Long toe (HP:0010511)1.72030776
127Abnormality of the peritoneum (HP:0002585)1.72022426
128Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70797841
129Joint stiffness (HP:0001387)1.70732142
130Nail dystrophy (HP:0008404)1.70506843
131Inguinal hernia (HP:0000023)1.70407338
132Disproportionate tall stature (HP:0001519)1.70279086
133Absent frontal sinuses (HP:0002688)1.69935620
134Onycholysis (HP:0001806)1.69689374
135Plantar hyperkeratosis (HP:0007556)1.68523701
136Delayed cranial suture closure (HP:0000270)1.68498443
137Myocardial infarction (HP:0001658)1.68418192
138Aplasia of the phalanges of the hand (HP:0009802)1.66930116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA33.80702016
2DDR23.41793727
3LATS13.18142948
4TTN2.85620540
5FER2.67051651
6EPHB12.64425140
7PDGFRA2.59200354
8SIK12.53395075
9TIE12.51691122
10EPHB22.34725462
11TGFBR22.33938651
12ERN12.30846630
13FGFR42.26579945
14KDR1.94979918
15ICK1.94252122
16RIPK11.93070999
17LATS21.88310850
18EPHA21.84927351
19NEK91.82874798
20TRPM71.82342142
21FLT31.79675573
22MAP3K61.69670254
23JAK11.60688045
24IRAK31.58710020
25PIK3CA1.52934877
26TRIB31.50747892
27FGFR31.50666816
28FRK1.50610090
29BMX1.44957020
30STK381.38683887
31PTK21.36799132
32STK31.35604940
33TESK11.34473821
34DMPK1.34332660
35CDK121.34153774
36CDC42BPA1.32563179
37STK38L1.30010848
38PRKD21.29029364
39PDGFRB1.28662553
40MET1.27207877
41MAP3K31.26758491
42AKT31.25440128
43NLK1.18661870
44PAK21.17815126
45PTK2B1.15997597
46NUAK11.14958697
47PAK31.10477305
48PRKCH1.10091742
49FGFR21.03666065
50CAMK1D1.03381827
51MST1R1.03370294
52MYLK1.03162786
53PTK61.02125877
54ZAK1.01770522
55SMG10.98649937
56TGFBR10.97040136
57SCYL20.95810367
58CDK80.94615727
59JAK30.89695476
60INSRR0.89299300
61ARAF0.85322806
62MELK0.84989103
63ROCK10.80980414
64PRKCE0.80923377
65ERBB30.80297437
66MAPKAPK30.79551503
67FGFR10.78862144
68EEF2K0.78708873
69MAP2K10.77990636
70NTRK10.74340039
71TYK20.73472807
72RET0.72425216
73MOS0.71511066
74WNK10.71505253
75IRAK10.69312959
76CASK0.68124943
77PDK20.67616002
78GSK3A0.67563943
79PAK40.66845413
80INSR0.66519770
81ABL20.65791474
82LRRK20.65596166
83STK240.64864460
84PRKD10.64675055
85CAMK1G0.64261369
86EIF2AK10.63029394
87PIK3CG0.62101932
88MTOR0.62040713
89KSR20.61167935
90RPS6KA20.59195251
91KIT0.57451184
92MAP3K20.57310085
93MAP3K90.56553104
94MUSK0.53482364
95PRKD30.51523668
96ILK0.49875377
97WNK40.49299061
98PKN20.49183670
99NEK10.49045809
100LMTK20.48638998
101EIF2AK20.48258321
102CDK60.48073776
103ROCK20.47718792
104OBSCN0.47253550
105MAPKAPK50.45721436
106IGF1R0.45527460
107RPS6KA40.45435845
108ADRBK10.44078100
109SRC0.43835581
110ERBB40.43513357
111PDPK10.42993018
112PRKG20.42147906
113MAPK110.42078491
114PLK20.41504853
115MAP3K10.40003581
116CLK10.39677743
117MAP3K130.38917238
118PRKAA20.38443555
119MAP3K140.37747109
120BMPR1B0.37137311
121ZAP700.36865793
122MAP3K70.36471242
123MAP3K80.35110185
124MAP3K120.34818093
125MAPKAPK20.33850110
126MAP2K30.33310068
127PIM20.33278036
128CHUK0.33060539
129PRPF4B0.32926275
130CAMK2G0.32711748
131CDK90.32594031
132ABL10.32192637
133LIMK10.31292678
134BRSK10.27956006
135PBK0.25986486
136CDK70.25401366
137GRK50.24892712
138KSR10.23749942

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.24169665
2Focal adhesion_Homo sapiens_hsa045102.91249330
3Malaria_Homo sapiens_hsa051442.76670922
4Adherens junction_Homo sapiens_hsa045202.42796084
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.27063687
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14695808
7Proteoglycans in cancer_Homo sapiens_hsa052052.14538758
8Amoebiasis_Homo sapiens_hsa051462.05101440
9Protein digestion and absorption_Homo sapiens_hsa049742.04065793
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.99859433
11Dilated cardiomyopathy_Homo sapiens_hsa054141.90765336
12TGF-beta signaling pathway_Homo sapiens_hsa043501.79643621
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74357865
14Small cell lung cancer_Homo sapiens_hsa052221.64877810
15* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.58522231
16Bladder cancer_Homo sapiens_hsa052191.54276632
17Melanoma_Homo sapiens_hsa052181.53211069
18Prion diseases_Homo sapiens_hsa050201.50314600
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49163378
20N-Glycan biosynthesis_Homo sapiens_hsa005101.42560797
21TNF signaling pathway_Homo sapiens_hsa046681.41763992
22Other glycan degradation_Homo sapiens_hsa005111.40097780
23MicroRNAs in cancer_Homo sapiens_hsa052061.35277653
24Hippo signaling pathway_Homo sapiens_hsa043901.33486491
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.33389125
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31581481
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30214981
28Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29578439
29Rap1 signaling pathway_Homo sapiens_hsa040151.29274427
30Toxoplasmosis_Homo sapiens_hsa051451.25438479
31Galactose metabolism_Homo sapiens_hsa000521.22131463
32Thyroid cancer_Homo sapiens_hsa052161.18969633
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18480938
34Caffeine metabolism_Homo sapiens_hsa002321.15378782
35Pancreatic cancer_Homo sapiens_hsa052121.14900544
36Axon guidance_Homo sapiens_hsa043601.09778329
37Pathways in cancer_Homo sapiens_hsa052001.09694208
38Basal cell carcinoma_Homo sapiens_hsa052171.05857072
39Tight junction_Homo sapiens_hsa045301.05258784
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04344506
41Prostate cancer_Homo sapiens_hsa052151.02490366
42Platelet activation_Homo sapiens_hsa046111.01212119
43Dorso-ventral axis formation_Homo sapiens_hsa043200.99998560
44Viral myocarditis_Homo sapiens_hsa054160.99592853
45Chronic myeloid leukemia_Homo sapiens_hsa052200.98175526
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97901897
47* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97383935
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94093574
49Ras signaling pathway_Homo sapiens_hsa040140.91328287
50Phagosome_Homo sapiens_hsa041450.91049383
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89392321
52Thyroid hormone synthesis_Homo sapiens_hsa049180.88055288
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85452274
54Ovarian steroidogenesis_Homo sapiens_hsa049130.84087189
55Complement and coagulation cascades_Homo sapiens_hsa046100.83613127
56African trypanosomiasis_Homo sapiens_hsa051430.83452031
57Vitamin B6 metabolism_Homo sapiens_hsa007500.82721477
58Salmonella infection_Homo sapiens_hsa051320.81976952
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.79921121
60Fructose and mannose metabolism_Homo sapiens_hsa000510.78993462
61HIF-1 signaling pathway_Homo sapiens_hsa040660.78981298
62Renal cell carcinoma_Homo sapiens_hsa052110.78570168
63Rheumatoid arthritis_Homo sapiens_hsa053230.77368887
64Leishmaniasis_Homo sapiens_hsa051400.77289837
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.76928134
66Insulin resistance_Homo sapiens_hsa049310.74437451
67PPAR signaling pathway_Homo sapiens_hsa033200.74398197
68Pentose phosphate pathway_Homo sapiens_hsa000300.73773816
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73541183
70ErbB signaling pathway_Homo sapiens_hsa040120.73011394
71Osteoclast differentiation_Homo sapiens_hsa043800.72784549
72Sphingolipid metabolism_Homo sapiens_hsa006000.72250739
73Glioma_Homo sapiens_hsa052140.70561668
74Vibrio cholerae infection_Homo sapiens_hsa051100.69386679
75* Jak-STAT signaling pathway_Homo sapiens_hsa046300.68192012
76Notch signaling pathway_Homo sapiens_hsa043300.68054475
77Wnt signaling pathway_Homo sapiens_hsa043100.66315945
78Hedgehog signaling pathway_Homo sapiens_hsa043400.65058844
79Hepatitis B_Homo sapiens_hsa051610.64645735
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64377789
81mTOR signaling pathway_Homo sapiens_hsa041500.64296488
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63288885
83Lysosome_Homo sapiens_hsa041420.61719316
84Melanogenesis_Homo sapiens_hsa049160.61527205
85Shigellosis_Homo sapiens_hsa051310.61427597
86HTLV-I infection_Homo sapiens_hsa051660.61363820
87Fatty acid biosynthesis_Homo sapiens_hsa000610.60919660
88Non-small cell lung cancer_Homo sapiens_hsa052230.60461474
89Bile secretion_Homo sapiens_hsa049760.60243707
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.59877907
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59625456
92Hepatitis C_Homo sapiens_hsa051600.59544523
93Pertussis_Homo sapiens_hsa051330.59083164
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.59082718
95Insulin signaling pathway_Homo sapiens_hsa049100.58183860
96FoxO signaling pathway_Homo sapiens_hsa040680.57842820
97MAPK signaling pathway_Homo sapiens_hsa040100.57430392
98Starch and sucrose metabolism_Homo sapiens_hsa005000.56301036
99Biosynthesis of amino acids_Homo sapiens_hsa012300.54836760
100Gap junction_Homo sapiens_hsa045400.53998184
101Apoptosis_Homo sapiens_hsa042100.53657190
102Endometrial cancer_Homo sapiens_hsa052130.53234129
103GnRH signaling pathway_Homo sapiens_hsa049120.51818034
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51210735
105Lysine degradation_Homo sapiens_hsa003100.51004041
106Prolactin signaling pathway_Homo sapiens_hsa049170.50540880
107Arginine biosynthesis_Homo sapiens_hsa002200.50100728
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49853815
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49625588
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49280992
111Estrogen signaling pathway_Homo sapiens_hsa049150.48698420
112Circadian rhythm_Homo sapiens_hsa047100.48694442
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48642398
114Endocytosis_Homo sapiens_hsa041440.48558310
115Acute myeloid leukemia_Homo sapiens_hsa052210.48183406
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.46337451
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.46308601
118Hematopoietic cell lineage_Homo sapiens_hsa046400.45811884
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.45705507
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44645251
121Phenylalanine metabolism_Homo sapiens_hsa003600.44485716
122Vitamin digestion and absorption_Homo sapiens_hsa049770.44192933
123Sulfur metabolism_Homo sapiens_hsa009200.44019409
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43998538
125Renin-angiotensin system_Homo sapiens_hsa046140.43779359
126AMPK signaling pathway_Homo sapiens_hsa041520.43335125
127ABC transporters_Homo sapiens_hsa020100.42933143
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42375951
129Mineral absorption_Homo sapiens_hsa049780.42196854
130p53 signaling pathway_Homo sapiens_hsa041150.42058277
131Glucagon signaling pathway_Homo sapiens_hsa049220.41948536
132VEGF signaling pathway_Homo sapiens_hsa043700.41392298
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41229974
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41149097
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40097610
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39229100

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