OSGIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.15218544
2L-phenylalanine catabolic process (GO:0006559)7.15218544
3L-phenylalanine metabolic process (GO:0006558)6.85087865
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.85087865
5aromatic amino acid family catabolic process (GO:0009074)6.48969009
6indole-containing compound catabolic process (GO:0042436)6.11268362
7indolalkylamine catabolic process (GO:0046218)6.11268362
8tryptophan catabolic process (GO:0006569)6.11268362
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05868087
10kynurenine metabolic process (GO:0070189)5.94003402
11bile acid biosynthetic process (GO:0006699)5.83646743
12glyoxylate metabolic process (GO:0046487)5.76545570
13tryptophan metabolic process (GO:0006568)5.71573371
14negative regulation of fibrinolysis (GO:0051918)5.49642291
15high-density lipoprotein particle remodeling (GO:0034375)5.48569160
16regulation of protein activation cascade (GO:2000257)5.48118924
17cysteine metabolic process (GO:0006534)5.43437518
18complement activation, alternative pathway (GO:0006957)5.42625460
19sulfur amino acid catabolic process (GO:0000098)5.38063982
20alpha-linolenic acid metabolic process (GO:0036109)5.34067449
21regulation of fibrinolysis (GO:0051917)5.33663922
22urea metabolic process (GO:0019627)5.30892487
23urea cycle (GO:0000050)5.30892487
24peptidyl-glutamic acid carboxylation (GO:0017187)5.24555681
25protein carboxylation (GO:0018214)5.24555681
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19856637
27regulation of complement activation (GO:0030449)5.12592803
28reverse cholesterol transport (GO:0043691)4.89771104
29bile acid metabolic process (GO:0008206)4.89694712
30nitrogen cycle metabolic process (GO:0071941)4.86670675
31epoxygenase P450 pathway (GO:0019373)4.84764566
32regulation of triglyceride catabolic process (GO:0010896)4.74746809
33serine family amino acid catabolic process (GO:0009071)4.73241974
34regulation of cholesterol esterification (GO:0010872)4.71830752
35aromatic amino acid family metabolic process (GO:0009072)4.68714606
36plasma lipoprotein particle remodeling (GO:0034369)4.66746073
37protein-lipid complex remodeling (GO:0034368)4.66746073
38macromolecular complex remodeling (GO:0034367)4.66746073
39homocysteine metabolic process (GO:0050667)4.50236253
40phospholipid efflux (GO:0033700)4.49403494
41triglyceride homeostasis (GO:0070328)4.49373496
42acylglycerol homeostasis (GO:0055090)4.49373496
43omega-hydroxylase P450 pathway (GO:0097267)4.49124487
44amino-acid betaine metabolic process (GO:0006577)4.47210835
45lysine catabolic process (GO:0006554)4.44192214
46lysine metabolic process (GO:0006553)4.44192214
47plasma lipoprotein particle clearance (GO:0034381)4.37304398
48negative regulation of cholesterol transport (GO:0032375)4.33865663
49negative regulation of sterol transport (GO:0032372)4.33865663
50benzene-containing compound metabolic process (GO:0042537)4.32922581
51alpha-amino acid catabolic process (GO:1901606)4.31509530
52tyrosine metabolic process (GO:0006570)4.31214992
53indolalkylamine metabolic process (GO:0006586)4.29671401
54glycosphingolipid catabolic process (GO:0046479)4.27545611
55cellular biogenic amine catabolic process (GO:0042402)4.24975904
56amine catabolic process (GO:0009310)4.24975904
57coenzyme catabolic process (GO:0009109)4.19394560
58cellular glucuronidation (GO:0052695)4.17074842
59cholesterol efflux (GO:0033344)4.14838276
60imidazole-containing compound metabolic process (GO:0052803)4.14600049
61bile acid and bile salt transport (GO:0015721)4.13780392
62response to nitrosative stress (GO:0051409)4.12939431
63ethanol oxidation (GO:0006069)4.07136139
64fibrinolysis (GO:0042730)4.06674425
65glutamate metabolic process (GO:0006536)4.06085106
66glycolipid catabolic process (GO:0019377)4.05862356
67low-density lipoprotein particle clearance (GO:0034383)4.02630525
68cellular modified amino acid catabolic process (GO:0042219)4.01354744
69plasma lipoprotein particle assembly (GO:0034377)4.00694732
70cellular amino acid catabolic process (GO:0009063)4.00486968
71polyketide metabolic process (GO:0030638)4.00455660
72doxorubicin metabolic process (GO:0044598)4.00455660
73daunorubicin metabolic process (GO:0044597)4.00455660
74glycine metabolic process (GO:0006544)3.99545473
75serine family amino acid metabolic process (GO:0009069)3.97382342
76cellular ketone body metabolic process (GO:0046950)3.92140579
77regulation of cholesterol homeostasis (GO:2000188)3.87320348
78aldehyde catabolic process (GO:0046185)3.85638604
79complement activation, classical pathway (GO:0006958)3.85075210
80positive regulation of lipoprotein lipase activity (GO:0051006)3.78503788
81positive regulation of triglyceride lipase activity (GO:0061365)3.78503788
82glucuronate metabolic process (GO:0019585)3.75290662
83uronic acid metabolic process (GO:0006063)3.75290662
84regulation of bile acid biosynthetic process (GO:0070857)3.74982246
85arginine metabolic process (GO:0006525)3.74973076
86complement activation (GO:0006956)3.74968923
87cofactor catabolic process (GO:0051187)3.73130808
88serine family amino acid biosynthetic process (GO:0009070)3.72402057
89blood coagulation, intrinsic pathway (GO:0007597)3.72222642
90cytolysis (GO:0019835)3.71049918
91protein activation cascade (GO:0072376)3.71018572
92low-density lipoprotein particle remodeling (GO:0034374)3.70634977
93oligosaccharide catabolic process (GO:0009313)3.70252544
94cholesterol homeostasis (GO:0042632)3.67287601
95phospholipid homeostasis (GO:0055091)3.65253275
96opsonization (GO:0008228)3.64308901
97drug catabolic process (GO:0042737)3.64297868
98acute-phase response (GO:0006953)3.63715629
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.63646890
100very-low-density lipoprotein particle assembly (GO:0034379)3.62469094
101sterol homeostasis (GO:0055092)3.61408422
102plasma lipoprotein particle organization (GO:0071827)3.60863639
103dicarboxylic acid biosynthetic process (GO:0043650)3.59462140
104protein-lipid complex assembly (GO:0065005)3.59324103
105fat-soluble vitamin biosynthetic process (GO:0042362)3.57768175
106positive regulation of lipid catabolic process (GO:0050996)3.57342084
107urate metabolic process (GO:0046415)3.57188037
108organic acid catabolic process (GO:0016054)3.55674319
109carboxylic acid catabolic process (GO:0046395)3.55674319
110negative regulation of protein activation cascade (GO:2000258)3.54656854
111negative regulation of lipase activity (GO:0060192)3.54292001
112aminoglycoside antibiotic metabolic process (GO:0030647)3.48145337
113positive regulation of extracellular matrix organization (GO:1903055)3.42628100
114glycoside metabolic process (GO:0016137)3.39952802
115ceramide catabolic process (GO:0046514)3.37607794
116exogenous drug catabolic process (GO:0042738)3.35445872
117negative regulation of blood coagulation (GO:0030195)3.29451151
118negative regulation of hemostasis (GO:1900047)3.29451151
119positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.23342276
120adhesion of symbiont to host (GO:0044406)3.19105242
121membrane lipid catabolic process (GO:0046466)3.18120836
122negative regulation of coagulation (GO:0050819)3.17888595
123cellular response to arsenic-containing substance (GO:0071243)3.10915348
124cellular response to thyroid hormone stimulus (GO:0097067)3.08855089
125regulation of mononuclear cell migration (GO:0071675)3.07176474
126regulation of cytokine secretion involved in immune response (GO:0002739)3.05474773
127regulation of cholesterol storage (GO:0010885)3.05173098
128response to thyroid hormone (GO:0097066)3.05011041
129positive regulation of fatty acid biosynthetic process (GO:0045723)3.02666868
130primary alcohol catabolic process (GO:0034310)3.01240612
131sphingolipid catabolic process (GO:0030149)2.97859764
132regulation of superoxide anion generation (GO:0032928)2.97466774
133regulation of vitamin metabolic process (GO:0030656)2.94176664
134negative regulation of fatty acid biosynthetic process (GO:0045717)2.93532748
135fructose metabolic process (GO:0006000)2.93245956
136lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90192392
137ethanol metabolic process (GO:0006067)2.88874692
138drug metabolic process (GO:0017144)2.87866585
139regulation of membrane protein ectodomain proteolysis (GO:0051043)2.87566379
140negative regulation of wound healing (GO:0061045)2.87103065
141positive regulation of hemostasis (GO:1900048)2.85065101
142positive regulation of blood coagulation (GO:0030194)2.85065101
143cyclooxygenase pathway (GO:0019371)2.85058078
144positive regulation of coagulation (GO:0050820)2.84463057
145flavonoid metabolic process (GO:0009812)2.82144948
146positive regulation of chemokine biosynthetic process (GO:0045080)2.78835092
147protein localization to endosome (GO:0036010)2.78406289
148regulation of vitamin D biosynthetic process (GO:0060556)2.77236802
149positive regulation of triglyceride metabolic process (GO:0090208)2.74704607
150regulation of early endosome to late endosome transport (GO:2000641)2.74468638
151intestinal cholesterol absorption (GO:0030299)2.71716918
152glucose 6-phosphate metabolic process (GO:0051156)2.68828132
153NIK/NF-kappaB signaling (GO:0038061)2.67438894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.92794792
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.93021765
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.63565784
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.23214350
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97541650
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.78814961
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.69269522
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.84648631
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.82433945
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.66439981
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.00951730
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3510041
13* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98540990
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96601562
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95184148
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.92619017
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91936518
18* ELK3_25401928_ChIP-Seq_HUVEC_Human1.89325247
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.86795372
20CLOCK_20551151_ChIP-Seq_293T_Human1.79692908
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63677615
22VDR_21846776_ChIP-Seq_THP-1_Human1.59752948
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.58175521
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51207528
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48054068
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46562123
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46421642
28GATA1_22025678_ChIP-Seq_K562_Human1.43537093
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38860446
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.37473679
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35948713
32* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32186447
33VDR_24763502_ChIP-Seq_THP-1_Human1.31932016
34TFEB_21752829_ChIP-Seq_HELA_Human1.29287799
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27664658
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25237320
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25141550
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21535044
39* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20902006
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20746131
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20456182
42SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20448475
43ATF3_27146783_Chip-Seq_COLON_Human1.20149872
44HTT_18923047_ChIP-ChIP_STHdh_Human1.19676206
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18576535
46RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18181773
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.18024597
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17135244
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14950448
50* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13628083
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13394743
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13287239
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12673769
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12388978
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.11246823
56SPI1_23127762_ChIP-Seq_K562_Human1.08959935
57* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07312188
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06657136
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05858284
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05446619
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04029739
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04027609
63* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03507385
64SMC4_20622854_ChIP-Seq_HELA_Human1.03445754
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.02278956
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.01089596
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00894739
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00799594
69VDR_24787735_ChIP-Seq_THP-1_Human0.99889622
70BCL6_27268052_Chip-Seq_Bcells_Human0.98792157
71* ESR1_20079471_ChIP-ChIP_T-47D_Human0.97959401
72RUNX1_27514584_Chip-Seq_MCF-7_Human0.97390267
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.96959303
74P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96889437
75GATA4_25053715_ChIP-Seq_YYC3_Human0.96701179
76RUNX1_22412390_ChIP-Seq_EML_Mouse0.95831684
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95829548
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95574911
79ESR1_21235772_ChIP-Seq_MCF-7_Human0.95376786
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94617974
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94159466
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94159466
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93380809
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93080573
85KDM2B_26808549_Chip-Seq_DND41_Human0.93053208
86* NCOR1_26117541_ChIP-Seq_K562_Human0.92612724
87P68_20966046_ChIP-Seq_HELA_Human0.92407089
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89793777
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85706349
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77554496
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77013520
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.76569665
93CDX2_20551321_ChIP-Seq_CACO-2_Human0.74851335
94ZNF263_19887448_ChIP-Seq_K562_Human0.73329489
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71140247
96* LXR_22292898_ChIP-Seq_THP-1_Human0.71091001
97* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70810656
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70793400
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70378704
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68339453
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67367136
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66859639
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66399128
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66388338
105AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66168334
106* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.65093481
107* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.65093481
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.65079214
109* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65043026
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63183940
111EGR1_19032775_ChIP-ChIP_M12_Human0.62849080
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62491703
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62216827
114GATA6_25053715_ChIP-Seq_YYC3_Human0.62211904
115RARB_24833708_ChIP-Seq_LIVER_Mouse0.62190966
116* CEBPB_22108803_ChIP-Seq_LS180_Human0.61434374
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.60233071
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58256801
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.57890354
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.57009663
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.56612252
122GATA2_19941826_ChIP-Seq_K562_Human0.55823615
123* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55401472
124GATA1_19941826_ChIP-Seq_K562_Human0.54890249
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52884375
126SOX2_20726797_ChIP-Seq_SW620_Human0.52815183
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.52489439
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.52409680
129* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52084604
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.52048613
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.51941218
132AR_20517297_ChIP-Seq_VCAP_Human0.51494734
133STAT1_17558387_ChIP-Seq_HELA_Human0.51058199
134MYC_19915707_ChIP-ChIP_AK7_Human0.50715473
135CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50214902
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.49814041
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49258582
138IRF8_27001747_Chip-Seq_BMDM_Mouse0.49060148
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48625241
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48525891
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.48510314
142ESET_19884257_ChIP-Seq_ESCs_Mouse0.48184645
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.45286439
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45108987
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.45081793
146P53_21459846_ChIP-Seq_SAOS-2_Human0.44659076
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44486709
148* RACK7_27058665_Chip-Seq_MCF-7_Human0.44089613
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.42397298
150ERG_20517297_ChIP-Seq_VCAP_Human0.42355211
151TRIM28_21343339_ChIP-Seq_HEK293_Human0.42266025
152SPI1_26923725_Chip-Seq_HPCs_Mouse0.41713217
153BCOR_27268052_Chip-Seq_Bcells_Human0.41557027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.93787248
2MP0005360_urolithiasis7.11286742
3MP0005085_abnormal_gallbladder_physiolo6.13357681
4MP0005365_abnormal_bile_salt5.92965344
5MP0008875_abnormal_xenobiotic_pharmacok4.87034204
6MP0003806_abnormal_nucleotide_metabolis4.09380902
7MP0003252_abnormal_bile_duct3.91314982
8MP0010329_abnormal_lipoprotein_level3.52022373
9MP0009840_abnormal_foam_cell3.33212438
10MP0005083_abnormal_biliary_tract3.14420289
11MP0001666_abnormal_nutrient_absorption2.71665454
12MP0003195_calcinosis2.67399531
13MP0005332_abnormal_amino_acid2.64610121
14MP0003191_abnormal_cellular_cholesterol2.44282637
15MP0003303_peritoneal_inflammation2.40366282
16MP0002138_abnormal_hepatobiliary_system2.36965841
17MP0003172_abnormal_lysosome_physiology2.32265262
18MP0000609_abnormal_liver_physiology2.16169575
19MP0004019_abnormal_vitamin_homeostasis2.15964866
20MP0002118_abnormal_lipid_homeostasis2.04936066
21MP0004510_myositis2.01757457
22MP0005319_abnormal_enzyme/_coenzyme1.90443800
23MP0000343_altered_response_to1.78456217
24MP0003868_abnormal_feces_composition1.76320352
25MP0002148_abnormal_hypersensitivity_rea1.72906165
26MP0002877_abnormal_melanocyte_morpholog1.60351170
27MP0001764_abnormal_homeostasis1.59862395
28MP0003453_abnormal_keratinocyte_physiol1.55968281
29MP0005584_abnormal_enzyme/coenzyme_acti1.52797349
30MP0003186_abnormal_redox_activity1.41820583
31MP0000371_diluted_coat_color1.40938191
32MP0003011_delayed_dark_adaptation1.38077054
33MP0005257_abnormal_intraocular_pressure1.34391367
34MP0009697_abnormal_copulation1.34374729
35MP0009643_abnormal_urine_homeostasis1.33750181
36MP0008260_abnormal_autophagy1.29081938
37MP0002254_reproductive_system_inflammat1.26994217
38MP0003656_abnormal_erythrocyte_physiolo1.26456759
39MP0000858_altered_metastatic_potential1.24436150
40MP0002998_abnormal_bone_remodeling1.23400954
41MP0010368_abnormal_lymphatic_system1.21351823
42MP0004233_abnormal_muscle_weight1.20856493
43MP0009764_decreased_sensitivity_to1.20756375
44MP0000598_abnormal_liver_morphology1.20558566
45MP0005451_abnormal_body_composition1.17867767
46MP0005647_abnormal_sex_gland1.15764417
47MP0000372_irregular_coat_pigmentation1.15617901
48MP0005084_abnormal_gallbladder_morpholo1.13331014
49MP0005167_abnormal_blood-brain_barrier1.11146089
50MP0003705_abnormal_hypodermis_morpholog1.11064486
51MP0005636_abnormal_mineral_homeostasis1.07797995
52MP0005025_abnormal_response_to1.07675036
53MP0001533_abnormal_skeleton_physiology1.07324501
54MP0006054_spinal_hemorrhage1.06888045
55MP0002332_abnormal_exercise_endurance1.05280588
56MP0009763_increased_sensitivity_to1.04870741
57MP0008469_abnormal_protein_level1.04749858
58MP0000604_amyloidosis0.99509368
59MP0010234_abnormal_vibrissa_follicle0.98578531
60MP0005670_abnormal_white_adipose0.95794650
61MP0005397_hematopoietic_system_phenotyp0.93983000
62MP0001545_abnormal_hematopoietic_system0.93983000
63MP0005000_abnormal_immune_tolerance0.92849706
64MP0009642_abnormal_blood_homeostasis0.90141900
65MP0005220_abnormal_exocrine_pancreas0.89789683
66MP0010155_abnormal_intestine_physiology0.89324497
67MP0000015_abnormal_ear_pigmentation0.87688138
68MP0005408_hypopigmentation0.84035781
69MP0003448_altered_tumor_morphology0.83986637
70MP0002928_abnormal_bile_duct0.82799783
71MP0003436_decreased_susceptibility_to0.81879519
72MP0005076_abnormal_cell_differentiation0.81306626
73MP0003724_increased_susceptibility_to0.80824564
74MP0003950_abnormal_plasma_membrane0.80682494
75MP0008004_abnormal_stomach_pH0.80097514
76MP0000920_abnormal_myelination0.79678296
77MP0005165_increased_susceptibility_to0.79319709
78MP0005248_abnormal_Harderian_gland0.78725258
79MP0005376_homeostasis/metabolism_phenot0.78600684
80MP0005387_immune_system_phenotype0.78172792
81MP0001790_abnormal_immune_system0.78172792
82MP0002090_abnormal_vision0.77856943
83MP0009765_abnormal_xenobiotic_induced0.77116581
84MP0001849_ear_inflammation0.76457910
85MP0002971_abnormal_brown_adipose0.74069851
86MP0009278_abnormal_bone_marrow0.73463708
87MP0005464_abnormal_platelet_physiology0.72754180
88MP0002078_abnormal_glucose_homeostasis0.72316076
89MP0005334_abnormal_fat_pad0.71383227
90MP0009053_abnormal_anal_canal0.70283054
91MP0009333_abnormal_splenocyte_physiolog0.69554389
92MP0006036_abnormal_mitochondrial_physio0.68940127
93MP0003879_abnormal_hair_cell0.67223396
94MP0002876_abnormal_thyroid_physiology0.66546826
95MP0001915_intracranial_hemorrhage0.65720192
96MP0002452_abnormal_antigen_presenting0.65153006
97MP0000639_abnormal_adrenal_gland0.64892419
98MP0005410_abnormal_fertilization0.64316734
99MP0002723_abnormal_immune_serum0.64200453
100MP0001756_abnormal_urination0.64116329
101MP0003091_abnormal_cell_migration0.62896405
102MP0002136_abnormal_kidney_physiology0.62419588
103MP0005310_abnormal_salivary_gland0.61484644
104MP0003690_abnormal_glial_cell0.60539890
105MP0003075_altered_response_to0.58161869
106MP0005535_abnormal_body_temperature0.58066987
107MP0005166_decreased_susceptibility_to0.56987901
108MP0005266_abnormal_metabolism0.56966156
109MP0004130_abnormal_muscle_cell0.55586364
110MP0002132_abnormal_respiratory_system0.54304833
111MP0003638_abnormal_response/metabolism_0.54031309
112MP0001661_extended_life_span0.48365629
113MP0004264_abnormal_extraembryonic_tissu0.48324251
114MP0006082_CNS_inflammation0.48090346
115MP0001845_abnormal_inflammatory_respons0.47985981
116MP0005448_abnormal_energy_balance0.47641895
117MP0004782_abnormal_surfactant_physiolog0.46162157
118MP0008873_increased_physiological_sensi0.43949079
119MP0009785_altered_susceptibility_to0.43590253
120MP0005395_other_phenotype0.43543080
121MP0001853_heart_inflammation0.43285362
122MP0003329_amyloid_beta_deposits0.42902359
123MP0003300_gastrointestinal_ulcer0.42774064
124MP0009384_cardiac_valve_regurgitation0.42685330
125MP0005058_abnormal_lysosome_morphology0.42186748
126MP0004883_abnormal_blood_vessel0.41479442
127MP0000249_abnormal_blood_vessel0.41421459
128MP0005023_abnormal_wound_healing0.41210754
129MP0003953_abnormal_hormone_level0.41083842
130MP0005164_abnormal_response_to0.38773054
131MP0005666_abnormal_adipose_tissue0.38175184
132MP0008874_decreased_physiological_sensi0.37956095
133MP0002796_impaired_skin_barrier0.37724263
134MP0009115_abnormal_fat_cell0.37483376
135MP0000579_abnormal_nail_morphology0.37421722
136MP0004947_skin_inflammation0.37205402
137MP0001881_abnormal_mammary_gland0.37099505
138MP0002135_abnormal_kidney_morphology0.36229511
139MP0000230_abnormal_systemic_arterial0.35277886
140MP0006035_abnormal_mitochondrial_morpho0.34679536
141MP0003718_maternal_effect0.33911630
142MP0002419_abnormal_innate_immunity0.33793054
143MP0004381_abnormal_hair_follicle0.33767646
144MP0001765_abnormal_ion_homeostasis0.32916904
145MP0001243_abnormal_dermal_layer0.32742305

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.13847362
2Deep venous thrombosis (HP:0002625)7.10771896
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.95674001
4Prolonged partial thromboplastin time (HP:0003645)6.35703147
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.28908403
6Abnormality of glycolipid metabolism (HP:0010969)6.13238727
7Abnormality of liposaccharide metabolism (HP:0010968)6.13238727
8Abnormality of glycosphingolipid metabolism (HP:0004343)6.13238727
9Xanthomatosis (HP:0000991)6.07362243
10Hypobetalipoproteinemia (HP:0003563)5.96436854
11Complement deficiency (HP:0004431)5.77754284
12Hyperlipoproteinemia (HP:0010980)5.07584159
13Joint hemorrhage (HP:0005261)4.85473516
14Abnormality of the common coagulation pathway (HP:0010990)4.69775367
15Hypolipoproteinemia (HP:0010981)4.56310836
16Fat malabsorption (HP:0002630)4.27863831
17Abnormality of complement system (HP:0005339)4.25290004
18Hyperammonemia (HP:0001987)4.23052965
19Dysostosis multiplex (HP:0000943)4.21512360
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.15633293
21Epidermoid cyst (HP:0200040)4.14957406
22Vacuolated lymphocytes (HP:0001922)4.14883275
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14700609
24Hyperglycinemia (HP:0002154)4.12195715
25Hypoalphalipoproteinemia (HP:0003233)4.03286447
26Ketosis (HP:0001946)4.02718437
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.94914931
28Increased cerebral lipofuscin (HP:0011813)3.93522531
29Abnormality of the intrinsic pathway (HP:0010989)3.81472413
30Hyperglycinuria (HP:0003108)3.80206325
31Loss of speech (HP:0002371)3.74888435
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.72489302
33Abnormality of serine family amino acid metabolism (HP:0010894)3.71214824
34Abnormality of glycine metabolism (HP:0010895)3.71214824
35Hypoglycemic coma (HP:0001325)3.68813398
36Abnormality of methionine metabolism (HP:0010901)3.65886015
37Abnormality of polysaccharide metabolism (HP:0011012)3.64150428
38Abnormality of glycosaminoglycan metabolism (HP:0004371)3.64150428
39Abnormality of mucopolysaccharide metabolism (HP:0011020)3.64150428
40Conjugated hyperbilirubinemia (HP:0002908)3.59935280
41Hypercholesterolemia (HP:0003124)3.56099399
42Urinary glycosaminoglycan excretion (HP:0003541)3.54543720
43Mucopolysacchariduria (HP:0008155)3.54543720
44Spontaneous abortion (HP:0005268)3.39188459
45Abnormality of pyrimidine metabolism (HP:0004353)3.33233257
46Increased neuronal autofluorescent lipopigment (HP:0002074)3.31419920
47Systemic lupus erythematosus (HP:0002725)3.31288323
48Abnormality of fatty-acid metabolism (HP:0004359)3.31153210
49Steatorrhea (HP:0002570)3.30019820
50Axonal loss (HP:0003447)3.29884659
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27193163
52Hyperbilirubinemia (HP:0002904)3.24555041
53Myocardial infarction (HP:0001658)3.20309722
54Disinhibition (HP:0000734)3.08581379
55Abnormality of nucleobase metabolism (HP:0010932)3.07270931
56Vascular calcification (HP:0004934)3.05458332
57Prolonged neonatal jaundice (HP:0006579)3.05357701
58Increased serum ferritin (HP:0003281)3.01415305
59Nuclear cataract (HP:0100018)3.00214038
60Gout (HP:0001997)2.96996131
61Hepatocellular carcinoma (HP:0001402)2.96119843
62Recurrent gram-negative bacterial infections (HP:0005420)2.94704555
63Abnormality of purine metabolism (HP:0004352)2.94289768
64Ketoacidosis (HP:0001993)2.86842372
65Purpura (HP:0000979)2.82380594
66Abnormality of the Achilles tendon (HP:0005109)2.80272561
67Delayed CNS myelination (HP:0002188)2.76400479
68Neurofibrillary tangles (HP:0002185)2.75101058
69Vertebral compression fractures (HP:0002953)2.72548577
70Cardiovascular calcification (HP:0011915)2.71813648
71Abnormality of serum amino acid levels (HP:0003112)2.68547458
72Glomerulonephritis (HP:0000099)2.63487184
73Abnormality of macrophages (HP:0004311)2.62660982
74Mitral stenosis (HP:0001718)2.61811362
75Amyloidosis (HP:0011034)2.61602152
76Metabolic acidosis (HP:0001942)2.60007589
77Hypochromic microcytic anemia (HP:0004840)2.55728651
78Cerebral inclusion bodies (HP:0100314)2.54497410
79Mutism (HP:0002300)2.51840169
80Skin nodule (HP:0200036)2.51551847
81Gingival bleeding (HP:0000225)2.48954679
82Achilles tendon contracture (HP:0001771)2.48808412
83Esophageal varix (HP:0002040)2.44049932
84Upper motor neuron abnormality (HP:0002127)2.43705600
85Generalized aminoaciduria (HP:0002909)2.41208228
86Asymmetric septal hypertrophy (HP:0001670)2.40480145
87Lethargy (HP:0001254)2.40237155
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40106255
89Dicarboxylic aciduria (HP:0003215)2.40106255
90Malnutrition (HP:0004395)2.40002735
91Abnormal gallbladder physiology (HP:0012438)2.38458488
92Cholecystitis (HP:0001082)2.38458488
93J-shaped sella turcica (HP:0002680)2.38450107
94Hypoglycemic seizures (HP:0002173)2.38089892
95Neonatal onset (HP:0003623)2.37372186
96Abnormal gallbladder morphology (HP:0012437)2.36825925
97Late onset (HP:0003584)2.33862146
98Abnormality of the vasculature of the conjunctiva (HP:0008054)2.32937440
99Cholelithiasis (HP:0001081)2.32712826
100Acanthocytosis (HP:0001927)2.32593829
101Thrombophlebitis (HP:0004418)2.30686945
102Sensorimotor neuropathy (HP:0007141)2.28704940
103Pancreatitis (HP:0001733)2.27253774
104Menorrhagia (HP:0000132)2.25520542
105Spastic diplegia (HP:0001264)2.24547323
106Pathologic fracture (HP:0002756)2.23521982
107Hemorrhage of the eye (HP:0011885)2.21289941
108Irritability (HP:0000737)2.17148720
109Progressive neurologic deterioration (HP:0002344)2.14999180
110Enlarged kidneys (HP:0000105)2.14520888
111Tetraparesis (HP:0002273)2.10901595
112Apathy (HP:0000741)2.10740561
113Abnormality of iron homeostasis (HP:0011031)2.10661995
114Abnormality of transition element cation homeostasis (HP:0011030)2.09436203
115Abnormality of proline metabolism (HP:0010907)2.08223918
116Hydroxyprolinuria (HP:0003080)2.08223918
117Diminished motivation (HP:0000745)2.07722791
118Distal lower limb muscle weakness (HP:0009053)2.07720610
119Elevated alkaline phosphatase (HP:0003155)2.07332562
120Retinal atrophy (HP:0001105)2.06769280
121Brushfield spots (HP:0001088)2.04205260
122Paraparesis (HP:0002385)2.03942846
123Bone pain (HP:0002653)2.03653124
124Vomiting (HP:0002013)2.01428550
125Cerebral edema (HP:0002181)2.00589339
126Abnormality of the gallbladder (HP:0005264)2.00406725
127Rickets (HP:0002748)2.00134051
128Opisthotonus (HP:0002179)1.96119117
129Abnormal enzyme/coenzyme activity (HP:0012379)1.96115502
130Nephritis (HP:0000123)1.95904798
131Neuronal loss in central nervous system (HP:0002529)1.95311835
132Increased purine levels (HP:0004368)1.94992185
133Hyperuricemia (HP:0002149)1.94992185
134Cardiomegaly (HP:0001640)1.92014998
135Nausea (HP:0002018)1.89804167
136Autoimmune thrombocytopenia (HP:0001973)1.89545629
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88279301
138Abnormality of alkaline phosphatase activity (HP:0004379)1.86250550
139Elevated hepatic transaminases (HP:0002910)1.84381693
140Hyperinsulinemic hypoglycemia (HP:0000825)1.84140361
141Hypophosphatemia (HP:0002148)1.83921598
142Hypophosphatemic rickets (HP:0004912)1.83527652
143Thoracic kyphosis (HP:0002942)1.83517662
144Abnormal cartilage morphology (HP:0002763)1.81589501
145Poikilocytosis (HP:0004447)1.79500755
146Proximal tubulopathy (HP:0000114)1.79412725
147Renal cortical cysts (HP:0000803)1.77106684
148Alkalosis (HP:0001948)1.76351674
149Metaphyseal irregularity (HP:0003025)1.76121793
150Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73418061
151Dementia (HP:0000726)1.71551872
152Conjunctival telangiectasia (HP:0000524)1.69356281
153Hypertriglyceridemia (HP:0002155)1.68553078
154Peripheral demyelination (HP:0011096)1.68078864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.06016530
2ERN15.10490325
3NME24.40329793
4FGFR44.39277976
5SIK13.87601873
6TAOK33.31563534
7DDR23.02834013
8ERBB42.86279341
9TESK12.48174572
10INSRR2.39456372
11MST1R2.10608199
12PIM22.07772908
13TYK22.00816073
14MAP3K31.84144248
15GRK71.84120481
16PRPF4B1.82865092
17PTK61.81976798
18TRIB31.81548253
19MAPK111.72483463
20EPHB11.67839159
21MATK1.63204466
22MAPK151.62490800
23ACVR1B1.62211339
24TBK11.59137797
25SIK31.58631520
26MAP2K31.57746742
27PIK3CG1.53856109
28MAP2K41.51911693
29IRAK31.50565738
30MAP3K141.49703442
31TGFBR21.44826278
32PKN21.43316293
33PAK41.42561414
34FLT31.40554347
35MAP3K71.38809075
36FGR1.34644553
37NEK91.32847451
38FRK1.28430589
39LATS11.26253339
40DAPK21.19195068
41JAK21.16881342
42CDC42BPA1.16678301
43RIPK11.14191393
44PDK21.14021647
45MAP3K111.10365906
46LIMK11.07940407
47KDR1.06704227
48JAK11.06301006
49MAP2K21.02374980
50ABL21.02333620
51PDGFRA1.01863816
52IKBKE0.98828318
53PRKAA20.96785081
54ARAF0.95190296
55LATS20.94602818
56TTN0.94500307
57EPHA20.94287383
58BLK0.93152452
59GRK60.92640127
60MAPKAPK30.92326397
61MAP3K100.92217280
62MOS0.91728497
63DYRK1B0.90442340
64PTK20.88420589
65MAPK40.88412100
66EPHA30.87822228
67ERBB20.87348742
68MET0.84999228
69CSK0.84551016
70TIE10.84127888
71MARK30.82046908
72IRAK20.80601423
73IRAK40.78565671
74MAP2K60.74894183
75STK38L0.74778454
76CDK60.74015069
77FGFR20.70803012
78BMPR20.70591388
79PRKCZ0.69715824
80GSK3A0.65355402
81PINK10.65165448
82SMG10.64323911
83MAP3K120.61089449
84MAP3K20.60655602
85PDPK10.59640718
86IKBKB0.58922551
87CSF1R0.57077785
88PBK0.56686423
89MAP3K10.55402108
90MUSK0.55137313
91CHUK0.54967308
92SGK30.54690446
93PRKACG0.53405204
94MAPK120.53143833
95ZAP700.52561011
96TAOK20.52502860
97CAMK1D0.52039288
98FGFR30.50752876
99MAP3K80.50657589
100MAPK70.50026910
101MAP4K10.49084765
102PRKAA10.48726533
103EIF2AK10.48611085
104CAMK2G0.47774180
105MAP2K10.45786725
106GRK10.44021584
107PAK30.43680063
108PDK40.43637017
109PDK30.43637017
110KIT0.42913292
111MAP3K50.41467451
112PRKG20.40214903
113BMX0.40061590
114ICK0.39741523
115DYRK30.39231227
116BTK0.39210357
117IGF1R0.38978466
118TYRO30.38576790
119SCYL20.37615239
120IRAK10.37122901
121EGFR0.36959131
122STK380.36419505
123PDK10.36102739
124KSR20.35707368
125RIPK40.34904135
126EPHB20.34352557
127PRKCQ0.34066341
128CAMK40.33866779
129SGK20.33520326
130BRAF0.33412050
131TAOK10.33242048
132TESK20.32919799
133RPS6KL10.31453912
134RPS6KC10.31453912
135MYLK0.31421608
136PRKD20.31263938
137CAMKK20.30968956
138MTOR0.30744175
139MAPKAPK20.30557689
140AKT30.30398920
141ABL10.29444055
142JAK30.28370075
143RPS6KA20.28198368
144LMTK20.28157648
145FER0.27873869
146NLK0.27003101
147STK30.26989295
148STK100.26696610

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54016443
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36962513
3Other glycan degradation_Homo sapiens_hsa005113.36902316
4Nitrogen metabolism_Homo sapiens_hsa009103.23058282
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.00955869
6Complement and coagulation cascades_Homo sapiens_hsa046102.94591856
7Arginine biosynthesis_Homo sapiens_hsa002202.84687009
8Tryptophan metabolism_Homo sapiens_hsa003802.68230650
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55375497
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.49622898
11Fatty acid degradation_Homo sapiens_hsa000712.49108335
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44415313
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37618757
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.32712918
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28662854
16Peroxisome_Homo sapiens_hsa041462.13311989
17Chemical carcinogenesis_Homo sapiens_hsa052042.10870979
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.07088614
19Butanoate metabolism_Homo sapiens_hsa006502.00168743
20Staphylococcus aureus infection_Homo sapiens_hsa051501.96773400
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.96510192
22Histidine metabolism_Homo sapiens_hsa003401.95376308
23PPAR signaling pathway_Homo sapiens_hsa033201.89699200
24Propanoate metabolism_Homo sapiens_hsa006401.82570521
25Caffeine metabolism_Homo sapiens_hsa002321.81808403
26Fatty acid metabolism_Homo sapiens_hsa012121.73481370
27Retinol metabolism_Homo sapiens_hsa008301.70464673
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.70033085
29Selenocompound metabolism_Homo sapiens_hsa004501.69426626
30beta-Alanine metabolism_Homo sapiens_hsa004101.65244240
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54265474
32Sulfur metabolism_Homo sapiens_hsa009201.49616734
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48528565
34Bile secretion_Homo sapiens_hsa049761.47956361
35Phenylalanine metabolism_Homo sapiens_hsa003601.44514828
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40596215
37Tyrosine metabolism_Homo sapiens_hsa003501.40505107
38Starch and sucrose metabolism_Homo sapiens_hsa005001.37171585
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35761717
40Pyruvate metabolism_Homo sapiens_hsa006201.34602385
41Fat digestion and absorption_Homo sapiens_hsa049751.32649696
42Folate biosynthesis_Homo sapiens_hsa007901.32424754
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28023231
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.25184401
45ABC transporters_Homo sapiens_hsa020101.23265094
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.21861753
47Steroid biosynthesis_Homo sapiens_hsa001001.17416264
48Fatty acid elongation_Homo sapiens_hsa000621.14101503
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13951866
50Rheumatoid arthritis_Homo sapiens_hsa053231.12227028
51Biosynthesis of amino acids_Homo sapiens_hsa012301.09275921
52Osteoclast differentiation_Homo sapiens_hsa043801.08998655
53Carbon metabolism_Homo sapiens_hsa012001.06881333
54Sulfur relay system_Homo sapiens_hsa041221.06815975
55Sphingolipid metabolism_Homo sapiens_hsa006001.04566722
56Vitamin digestion and absorption_Homo sapiens_hsa049771.00382295
57TNF signaling pathway_Homo sapiens_hsa046680.99846028
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.99116468
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98537355
60Vitamin B6 metabolism_Homo sapiens_hsa007500.98446709
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98411435
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93716984
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93381107
64Arginine and proline metabolism_Homo sapiens_hsa003300.91902161
65Glutathione metabolism_Homo sapiens_hsa004800.90715471
66Legionellosis_Homo sapiens_hsa051340.89992199
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.87161049
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86720006
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86682992
70Salmonella infection_Homo sapiens_hsa051320.86297606
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79674040
72Glycerolipid metabolism_Homo sapiens_hsa005610.77169025
73Lysine degradation_Homo sapiens_hsa003100.74262249
74Tuberculosis_Homo sapiens_hsa051520.70991130
75Vibrio cholerae infection_Homo sapiens_hsa051100.70861613
76Malaria_Homo sapiens_hsa051440.70140035
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66289017
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64743839
79One carbon pool by folate_Homo sapiens_hsa006700.62117344
80Pentose phosphate pathway_Homo sapiens_hsa000300.62089612
81Leishmaniasis_Homo sapiens_hsa051400.61173282
82Phagosome_Homo sapiens_hsa041450.59353549
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55640587
84Collecting duct acid secretion_Homo sapiens_hsa049660.52893378
85Fatty acid biosynthesis_Homo sapiens_hsa000610.51292030
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50595158
87Toxoplasmosis_Homo sapiens_hsa051450.47225048
88Prion diseases_Homo sapiens_hsa050200.43653826
89Metabolic pathways_Homo sapiens_hsa011000.43106972
90Galactose metabolism_Homo sapiens_hsa000520.41567143
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41409997
92Influenza A_Homo sapiens_hsa051640.41072944
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37524501
94Shigellosis_Homo sapiens_hsa051310.35014190
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34515366
96Fructose and mannose metabolism_Homo sapiens_hsa000510.31055103
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.29663827
98Insulin resistance_Homo sapiens_hsa049310.29521981
99Apoptosis_Homo sapiens_hsa042100.27143826
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25249047
101Acute myeloid leukemia_Homo sapiens_hsa052210.23069312
102Linoleic acid metabolism_Homo sapiens_hsa005910.22402165
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.20064182
104Glucagon signaling pathway_Homo sapiens_hsa049220.10585273
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.02292537
106Lysosome_Homo sapiens_hsa04142-0.1881059
107Protein digestion and absorption_Homo sapiens_hsa04974-0.1821692
108Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1727266
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1548798
110Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1430902
111Amoebiasis_Homo sapiens_hsa05146-0.1414228
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1385596
113Mineral absorption_Homo sapiens_hsa04978-0.1280954
114Insulin signaling pathway_Homo sapiens_hsa04910-0.1221403
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1042864
116Renin-angiotensin system_Homo sapiens_hsa04614-0.0955806
117African trypanosomiasis_Homo sapiens_hsa05143-0.0923272
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0914203
119Bladder cancer_Homo sapiens_hsa05219-0.0876900
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0844446
121Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0839648
122Pertussis_Homo sapiens_hsa05133-0.0726874
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0438761
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0385007
125Hepatitis C_Homo sapiens_hsa05160-0.0347387
126Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0201790
127AMPK signaling pathway_Homo sapiens_hsa04152-0.0046411

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