OSBPL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.66942551
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.66942551
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.66942551
4modulation by symbiont of host immune response (GO:0052553)6.66942551
5positive regulation by symbiont of host defense response (GO:0052509)6.66942551
6modulation by symbiont of host defense response (GO:0052031)6.66942551
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.17497364
8detection of molecule of bacterial origin (GO:0032490)5.39114642
9regulation of interferon-beta biosynthetic process (GO:0045357)5.35660259
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.92743049
11negative regulation of cell killing (GO:0031342)4.92743049
12positive regulation of gamma-delta T cell activation (GO:0046645)4.84829830
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.59696145
14macrophage activation involved in immune response (GO:0002281)4.57240675
15response to host immune response (GO:0052572)4.50696054
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.50696054
17neutrophil activation involved in immune response (GO:0002283)4.49778977
18neutrophil mediated immunity (GO:0002446)4.29076689
19regulation of B cell receptor signaling pathway (GO:0050855)4.20477536
20response to host (GO:0075136)4.09695602
21response to host defenses (GO:0052200)4.09695602
22response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.09695602
23natural killer cell mediated immunity (GO:0002228)3.95611134
24natural killer cell mediated cytotoxicity (GO:0042267)3.95611134
25positive regulation of B cell differentiation (GO:0045579)3.94865476
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.91327263
27positive regulation of interferon-alpha production (GO:0032727)3.90060003
28response to peptidoglycan (GO:0032494)3.86200059
29myeloid cell activation involved in immune response (GO:0002275)3.83340481
30phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.82143389
31detection of external biotic stimulus (GO:0098581)3.81056856
32regulation of interferon-alpha production (GO:0032647)3.75122727
33nuclear pore complex assembly (GO:0051292)3.58279008
34hypotonic response (GO:0006971)3.55836577
35detection of other organism (GO:0098543)3.50990440
36pinocytosis (GO:0006907)3.47266119
37myeloid leukocyte mediated immunity (GO:0002444)3.43903561
38I-kappaB phosphorylation (GO:0007252)3.42592478
39negative regulation of interleukin-12 production (GO:0032695)3.39757209
40germinal center formation (GO:0002467)3.36969268
41detection of biotic stimulus (GO:0009595)3.30221058
42immunoglobulin mediated immune response (GO:0016064)3.30164744
43microglial cell activation (GO:0001774)3.30152833
44response to muramyl dipeptide (GO:0032495)3.27463894
45negative regulation of interleukin-17 production (GO:0032700)3.26762318
46B cell receptor signaling pathway (GO:0050853)3.23357275
47hepatocyte apoptotic process (GO:0097284)3.22459382
48negative regulation of T cell mediated immunity (GO:0002710)3.21637278
49histone H3-K36 demethylation (GO:0070544)3.19628411
50regulation of gamma-delta T cell activation (GO:0046643)3.18997817
51regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.16376325
52B cell homeostasis (GO:0001782)3.13141791
53respiratory burst (GO:0045730)3.11827394
54neutrophil activation (GO:0042119)3.10548333
55regulation of mast cell degranulation (GO:0043304)3.05065830
56granulocyte activation (GO:0036230)3.04760195
57regulation of gamma-delta T cell differentiation (GO:0045586)3.04011494
58dosage compensation (GO:0007549)3.01965066
59positive regulation of mast cell activation (GO:0033005)3.01489757
60regulation of mast cell activation (GO:0033003)2.98817672
61response to interleukin-15 (GO:0070672)2.98248647
62regulation of interleukin-8 biosynthetic process (GO:0045414)2.97960796
63neural tube formation (GO:0001841)2.96723393
64positive regulation of interferon-beta production (GO:0032728)2.95145045
65lipoprotein transport (GO:0042953)2.94372191
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92532975
67macrophage activation (GO:0042116)2.92340312
68nuclear pore organization (GO:0006999)2.91364894
69positive regulation of antigen processing and presentation (GO:0002579)2.90679015
70regulation of mast cell activation involved in immune response (GO:0033006)2.89987752
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88857622
72leukocyte aggregation (GO:0070486)2.88373220
73negative regulation of lymphocyte mediated immunity (GO:0002707)2.87732862
74modulation by symbiont of host cellular process (GO:0044068)2.84559798
75regulation of leukocyte degranulation (GO:0043300)2.83957448
76embryonic process involved in female pregnancy (GO:0060136)2.82624666
77positive regulation of cellular amide metabolic process (GO:0034250)2.79087085
78regulation of B cell differentiation (GO:0045577)2.77411946
79defense response to protozoan (GO:0042832)2.75917690
80cytoplasmic mRNA processing body assembly (GO:0033962)2.73862505
81leukocyte mediated cytotoxicity (GO:0001909)2.73454468
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70882245
83regulation of interleukin-12 biosynthetic process (GO:0045075)2.68148402
84pore complex assembly (GO:0046931)2.67694927
85mast cell activation (GO:0045576)2.67443921
86nerve growth factor signaling pathway (GO:0038180)2.66517101
87negative T cell selection (GO:0043383)2.66384543
88leukocyte degranulation (GO:0043299)2.65870252
89regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65669012
90detection of bacterium (GO:0016045)2.63961892
91regulation of macrophage cytokine production (GO:0010935)2.63892959
92cellular response to ethanol (GO:0071361)2.62438990
93positive regulation of leukocyte apoptotic process (GO:2000108)2.62283168
94establishment of protein localization to vacuole (GO:0072666)2.61295440
95protein targeting to vacuole (GO:0006623)2.61295440
96protein targeting to lysosome (GO:0006622)2.61295440
97dendritic cell migration (GO:0036336)2.61229550
98cellular extravasation (GO:0045123)2.58573078
99regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.58182023
100positive T cell selection (GO:0043368)2.57465510
101regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.56853120
102monoubiquitinated protein deubiquitination (GO:0035520)2.56077201
103myeloid leukocyte activation (GO:0002274)2.55713880
104positive regulation of mast cell activation involved in immune response (GO:0033008)2.55478586
105positive regulation of mast cell degranulation (GO:0043306)2.55478586
106production of molecular mediator involved in inflammatory response (GO:0002532)2.55343871
107definitive hemopoiesis (GO:0060216)2.55194419
108positive regulation of toll-like receptor signaling pathway (GO:0034123)2.55154178
109negative regulation of T-helper cell differentiation (GO:0045623)2.54107092
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.54107092
111negative thymic T cell selection (GO:0045060)2.53097222
112negative regulation of NF-kappaB import into nucleus (GO:0042347)2.53094755
113mast cell activation involved in immune response (GO:0002279)2.51928700
114mast cell degranulation (GO:0043303)2.51928700
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51894915
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51894915
117antigen processing and presentation via MHC class Ib (GO:0002475)2.49899614
118regulation of interleukin-6 biosynthetic process (GO:0045408)2.48819994
119response to protozoan (GO:0001562)2.48791595
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48578164
121myeloid dendritic cell activation (GO:0001773)2.48334482
122histone H3-K9 demethylation (GO:0033169)2.48017564
123negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.47963705
124iron ion import (GO:0097286)2.46374800
125negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.46319000
126positive regulation of macrophage cytokine production (GO:0060907)2.45884866
127histone H3-K4 trimethylation (GO:0080182)2.45792096
128positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45743873
129NIK/NF-kappaB signaling (GO:0038061)2.45684548
130cell adhesion mediated by integrin (GO:0033627)2.45436826
131regulation of T-helper 2 cell differentiation (GO:0045628)2.45244087
132neutrophil chemotaxis (GO:0030593)2.44527259
133actin nucleation (GO:0045010)2.44213713
134interferon-gamma-mediated signaling pathway (GO:0060333)2.44132167
135positive regulation of granulocyte differentiation (GO:0030854)2.44106755
136regulation of NFAT protein import into nucleus (GO:0051532)2.44040855
137regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44035915
138negative regulation of type 2 immune response (GO:0002829)2.43933953
139lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42871063
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42515962
141regulation of cholesterol storage (GO:0010885)2.41837005
142neutrophil migration (GO:1990266)2.41399017
143negative regulation of mast cell activation (GO:0033004)2.40293702
144positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40033519
145G-protein coupled receptor internalization (GO:0002031)2.39611892
146regulation of regulated secretory pathway (GO:1903305)2.38281671
147adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.37099572
148clathrin coat assembly (GO:0048268)2.37051740
149positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.36181998
150Arp2/3 complex-mediated actin nucleation (GO:0034314)2.35734042
151negative regulation of granulocyte differentiation (GO:0030853)2.34989546
152regulation of integrin activation (GO:0033623)2.34879123
153B cell proliferation (GO:0042100)2.33947155
154positive regulation of bone resorption (GO:0045780)2.33858921
155positive regulation of bone remodeling (GO:0046852)2.33858921
156mature B cell differentiation (GO:0002335)2.32801002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.89839130
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.70016219
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.20617833
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.88596070
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.86693546
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.81857799
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74996951
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.60957369
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45543323
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.34539088
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.11595360
12SCL_19346495_ChIP-Seq_HPC-7_Human2.98890473
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.87952638
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81067052
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67532365
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67503826
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44356387
18SPI1_23127762_ChIP-Seq_K562_Human2.33327474
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.30853693
20* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.26060524
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23562386
22E2F7_22180533_ChIP-Seq_HELA_Human2.12707137
23GATA1_22025678_ChIP-Seq_K562_Human2.10957574
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09010871
25* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05975976
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05837891
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.00520410
28RUNX_20019798_ChIP-Seq_JUKART_Human1.94508339
29* PU_27001747_Chip-Seq_BMDM_Mouse1.92806199
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.92659546
31SPI1_23547873_ChIP-Seq_NB4_Human1.85349853
32VDR_24787735_ChIP-Seq_THP-1_Human1.84812532
33VDR_24763502_ChIP-Seq_THP-1_Human1.80589045
34MYB_26560356_Chip-Seq_TH2_Human1.75849393
35* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75287667
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.74028741
37VDR_21846776_ChIP-Seq_THP-1_Human1.73154570
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72385748
39* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71853796
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.70302277
41TAF15_26573619_Chip-Seq_HEK293_Human1.66506033
42* TCF7_22412390_ChIP-Seq_EML_Mouse1.65984374
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.65821900
44* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61539299
45MYB_26560356_Chip-Seq_TH1_Human1.60686506
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.60416775
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57311804
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54731808
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51106543
50MAF_26560356_Chip-Seq_TH1_Human1.49421789
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44180537
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43515523
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42891049
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40595505
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39134313
56GATA3_27048872_Chip-Seq_THYMUS_Human1.38022854
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37522674
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37196696
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.32831955
60* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32258762
61* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32258762
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29934162
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29830211
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29191420
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26842685
66* BRD4_25478319_ChIP-Seq_HGPS_Human1.26788398
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25504749
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24308509
69MYC_22102868_ChIP-Seq_BL_Human1.24103909
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21882261
71* UTX_26944678_Chip-Seq_JUKART_Human1.21035265
72* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20752832
73GATA3_26560356_Chip-Seq_TH2_Human1.18177805
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17803346
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17580210
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17260370
77* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16301923
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16153630
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14685419
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12799757
81KDM2B_26808549_Chip-Seq_DND41_Human1.12633346
82* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11888845
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11074319
84* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10850303
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10654376
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.09917480
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09634336
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08606143
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08527816
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08079239
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07145479
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06785478
93GATA2_19941826_ChIP-Seq_K562_Human1.06235665
94GATA1_19941826_ChIP-Seq_K562_Human1.05749825
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.05301299
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05127506
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.03871875
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.03616809
99* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03226072
100SMAD4_21799915_ChIP-Seq_A2780_Human1.03161386
101ER_23166858_ChIP-Seq_MCF-7_Human1.03050379
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.02547903
103TP53_16413492_ChIP-PET_HCT116_Human1.02428695
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.01298279
105* FOXO3_23340844_ChIP-Seq_DLD1_Human1.00706363
106GBX2_23144817_ChIP-Seq_PC3_Human1.00569314
107FUS_26573619_Chip-Seq_HEK293_Human1.00099079
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98200447
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98120417
110PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98050729
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97983077
112STAT3_23295773_ChIP-Seq_U87_Human0.97458414
113* TP63_23658742_ChIP-Seq_EP156T_Human0.97408583
114SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96975831
115SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96057346
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96057346
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95248529
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.94570109
119IGF1R_20145208_ChIP-Seq_DFB_Human0.94183101
120* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93847399
121* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92582833
122P300_19829295_ChIP-Seq_ESCs_Human0.92538244
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91983073
124* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91314980
125RXR_22108803_ChIP-Seq_LS180_Human0.90322580
126SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89973152
127* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89918032
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89424038
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89195417
130* TFEB_21752829_ChIP-Seq_HELA_Human0.86533195
131SMRT_27268052_Chip-Seq_Bcells_Human0.85995025
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84993389
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83923139
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83622556
135* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81050195
136* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77431868
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75999605
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75863671
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.73386770
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72891251
141* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.72846013
142GATA3_26560356_Chip-Seq_TH1_Human0.72805713
143KDM2B_26808549_Chip-Seq_JURKAT_Human0.72720877
144RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71995472
145ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71453249
146* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71012040
147* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.70964922
148* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69777158
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.69285239
150LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69059564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.11381626
2MP0008057_abnormal_DNA_replication3.71259228
3MP0003172_abnormal_lysosome_physiology3.65386065
4MP0005058_abnormal_lysosome_morphology3.60962803
5MP0003303_peritoneal_inflammation3.45870194
6MP0002009_preneoplasia3.33185531
7MP0001835_abnormal_antigen_presentation3.31101471
8MP0005174_abnormal_tail_pigmentation2.96010803
9MP0003436_decreased_susceptibility_to2.84088358
10MP0003300_gastrointestinal_ulcer2.74677342
11MP0002419_abnormal_innate_immunity2.65222001
12MP0004510_myositis2.54484177
13MP0005464_abnormal_platelet_physiology2.44450722
14MP0000015_abnormal_ear_pigmentation2.36457960
15MP0005000_abnormal_immune_tolerance2.27964519
16MP0002452_abnormal_antigen_presenting2.18752635
17MP0001800_abnormal_humoral_immune2.17576065
18MP0006082_CNS_inflammation2.14942611
19MP0003221_abnormal_cardiomyocyte_apopto2.04283300
20MP0002166_altered_tumor_susceptibility2.02268076
21MP0004883_abnormal_blood_vessel2.01021379
22MP0002723_abnormal_immune_serum2.00847681
23MP0001790_abnormal_immune_system1.98852992
24MP0005387_immune_system_phenotype1.98852992
25MP0010307_abnormal_tumor_latency1.98400689
26MP0005025_abnormal_response_to1.97650847
27MP0009785_altered_susceptibility_to1.95204989
28MP0003183_abnormal_peptide_metabolism1.92856602
29MP0009278_abnormal_bone_marrow1.91597744
30MP0001819_abnormal_immune_cell1.89059068
31MP0002420_abnormal_adaptive_immunity1.88791616
32MP0005671_abnormal_response_to1.85893113
33MP0002396_abnormal_hematopoietic_system1.80023324
34MP0005451_abnormal_body_composition1.75632937
35MP0003787_abnormal_imprinting1.73116739
36MP0001545_abnormal_hematopoietic_system1.69704861
37MP0005397_hematopoietic_system_phenotyp1.69704861
38MP0000604_amyloidosis1.68371182
39MP0000685_abnormal_immune_system1.67550091
40MP0006054_spinal_hemorrhage1.65243556
41MP0002148_abnormal_hypersensitivity_rea1.63769628
42MP0002006_tumorigenesis1.63513294
43MP0002398_abnormal_bone_marrow1.55993851
44MP0004947_skin_inflammation1.50273810
45MP0004808_abnormal_hematopoietic_stem1.47079317
46MP0000689_abnormal_spleen_morphology1.45232552
47MP0000716_abnormal_immune_system1.43909239
48MP0005164_abnormal_response_to1.43774711
49MP0005310_abnormal_salivary_gland1.42865618
50MP0005409_darkened_coat_color1.41577155
51MP0003690_abnormal_glial_cell1.40048754
52MP0002405_respiratory_system_inflammati1.39909386
53MP0001845_abnormal_inflammatory_respons1.38263076
54MP0000371_diluted_coat_color1.36402492
55MP0003448_altered_tumor_morphology1.36046820
56MP0003705_abnormal_hypodermis_morpholog1.33649314
57MP0003656_abnormal_erythrocyte_physiolo1.33179219
58MP0000465_gastrointestinal_hemorrhage1.31551573
59MP0001533_abnormal_skeleton_physiology1.30744058
60MP0002722_abnormal_immune_system1.25448774
61MP0004381_abnormal_hair_follicle1.23763584
62MP0005076_abnormal_cell_differentiation1.22457121
63MP0003191_abnormal_cellular_cholesterol1.21317696
64MP0005275_abnormal_skin_tensile1.20865998
65MP0003075_altered_response_to1.19541683
66MP0003724_increased_susceptibility_to1.18265285
67MP0008469_abnormal_protein_level1.17759063
68MP0002429_abnormal_blood_cell1.16610714
69MP0002998_abnormal_bone_remodeling1.14637900
70MP0003566_abnormal_cell_adhesion1.13530637
71MP0003828_pulmonary_edema1.12124786
72MP0010155_abnormal_intestine_physiology1.11624442
73MP0004130_abnormal_muscle_cell1.10728608
74MP0008438_abnormal_cutaneous_collagen1.07117683
75MP0001958_emphysema1.06558085
76MP0009764_decreased_sensitivity_to1.06101487
77MP0008004_abnormal_stomach_pH1.05904915
78MP0001851_eye_inflammation1.04108144
79MP0003890_abnormal_embryonic-extraembry1.03749155
80MP0002877_abnormal_melanocyte_morpholog1.02794599
81MP0005167_abnormal_blood-brain_barrier1.02761527
82MP0001853_heart_inflammation1.02423131
83MP0008877_abnormal_DNA_methylation1.01722905
84MP0004185_abnormal_adipocyte_glucose0.99498496
85MP0001873_stomach_inflammation0.99258030
86MP0009840_abnormal_foam_cell0.97684886
87MP0010678_abnormal_skin_adnexa0.97459758
88MP0002095_abnormal_skin_pigmentation0.94564914
89MP0000703_abnormal_thymus_morphology0.92474067
90MP0000343_altered_response_to0.91227161
91MP0004484_altered_response_of0.90322421
92MP0005166_decreased_susceptibility_to0.89231691
93MP0005388_respiratory_system_phenotype0.88838887
94MP0002133_abnormal_respiratory_system0.88838887
95MP0004859_abnormal_synaptic_plasticity0.88795236
96MP0003091_abnormal_cell_migration0.88577824
97MP0002332_abnormal_exercise_endurance0.87940219
98MP0005257_abnormal_intraocular_pressure0.81742088
99MP0003763_abnormal_thymus_physiology0.81124827
100MP0009763_increased_sensitivity_to0.80983494
101MP0002928_abnormal_bile_duct0.78432311
102MP0000427_abnormal_hair_cycle0.78322986
103MP0003453_abnormal_keratinocyte_physiol0.77548956
104MP0000858_altered_metastatic_potential0.75270211
105MP0005248_abnormal_Harderian_gland0.72932544
106MP0003632_abnormal_nervous_system0.70279802
107MP0002075_abnormal_coat/hair_pigmentati0.66003404
108MP0008260_abnormal_autophagy0.63871447
109MP0005621_abnormal_cell_physiology0.63492033
110MP0005384_cellular_phenotype0.63356989
111MP0001188_hyperpigmentation0.62822097
112MP0000383_abnormal_hair_follicle0.62619957
113MP0005075_abnormal_melanosome_morpholog0.62496377
114MP0002138_abnormal_hepatobiliary_system0.60027836
115MP0009333_abnormal_splenocyte_physiolog0.58912320
116MP0010352_gastrointestinal_tract_polyps0.55919301
117MP0001915_intracranial_hemorrhage0.55727714
118MP0002090_abnormal_vision0.55536582
119MP0000490_abnormal_crypts_of0.55105484
120MP0009046_muscle_twitch0.53874753
121MP0003633_abnormal_nervous_system0.53196414
122MP0003866_abnormal_defecation0.52128115
123MP0009765_abnormal_xenobiotic_induced0.51532537
124MP0000249_abnormal_blood_vessel0.51487607
125MP0003795_abnormal_bone_structure0.50377750
126MP0005197_abnormal_uvea_morphology0.50202457
127MP0000767_abnormal_smooth_muscle0.49369643
128MP0002136_abnormal_kidney_physiology0.49089862
129MP0010234_abnormal_vibrissa_follicle0.47341699

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.06481056
2Recurrent bacterial skin infections (HP:0005406)5.70088179
3Increased cerebral lipofuscin (HP:0011813)4.80802395
4Eczematoid dermatitis (HP:0000976)4.66376593
5Papillary thyroid carcinoma (HP:0002895)4.31015412
6T lymphocytopenia (HP:0005403)4.24429184
7Recurrent gram-negative bacterial infections (HP:0005420)4.10064008
8Abnormality of macrophages (HP:0004311)4.05526762
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.97513813
10Vacuolated lymphocytes (HP:0001922)3.90211908
11Subacute progressive viral hepatitis (HP:0006572)3.88272286
12Prostate neoplasm (HP:0100787)3.78156850
13Abnormality of T cell number (HP:0011839)3.72333834
14Disinhibition (HP:0000734)3.71377763
15Spontaneous hematomas (HP:0007420)3.47050968
16Recurrent skin infections (HP:0001581)3.45626395
17Recurrent fungal infections (HP:0002841)3.43503108
18Gingivitis (HP:0000230)3.39002503
19Mediastinal lymphadenopathy (HP:0100721)3.26288760
20Autoimmune thrombocytopenia (HP:0001973)3.13979181
21Recurrent viral infections (HP:0004429)3.13812664
22Myositis (HP:0100614)3.09907736
23Stomatitis (HP:0010280)3.01545823
24Periodontitis (HP:0000704)2.99643044
25Axonal loss (HP:0003447)2.98698817
26Abnormality of liposaccharide metabolism (HP:0010968)2.95987219
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.95987219
28Abnormality of glycolipid metabolism (HP:0010969)2.95987219
29Thyroid carcinoma (HP:0002890)2.92745730
30Hematochezia (HP:0002573)2.88756293
31Dysostosis multiplex (HP:0000943)2.88084158
32Optic neuritis (HP:0100653)2.86267778
33Retrobulbar optic neuritis (HP:0100654)2.86267778
34Thick nail (HP:0001805)2.82270549
35Myocardial infarction (HP:0001658)2.77859159
36Cellulitis (HP:0100658)2.72748494
37Keratoconjunctivitis sicca (HP:0001097)2.71890456
38Abnormality of polysaccharide metabolism (HP:0011012)2.71487389
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.71487389
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.71487389
41Obstructive lung disease (HP:0006536)2.71213309
42Chronic obstructive pulmonary disease (HP:0006510)2.71213309
43Inappropriate behavior (HP:0000719)2.68959879
44Spinal cord lesions (HP:0100561)2.68894804
45Syringomyelia (HP:0003396)2.68894804
46Orchitis (HP:0100796)2.67814372
47Peritonitis (HP:0002586)2.65963814
48Arterial thrombosis (HP:0004420)2.62659204
49Gingival bleeding (HP:0000225)2.58724035
50Abnormality of the prostate (HP:0008775)2.58549315
51Urinary glycosaminoglycan excretion (HP:0003541)2.58120358
52Mucopolysacchariduria (HP:0008155)2.58120358
53Viral hepatitis (HP:0006562)2.57056810
54Abnormality of the fingertips (HP:0001211)2.56283969
55Global brain atrophy (HP:0002283)2.55697187
56Chronic mucocutaneous candidiasis (HP:0002728)2.54430858
57Recurrent cutaneous fungal infections (HP:0011370)2.54430858
58Absent frontal sinuses (HP:0002688)2.54109739
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.54064022
60Impaired platelet aggregation (HP:0003540)2.52186177
61Abnormal platelet function (HP:0011869)2.52186177
62Papilledema (HP:0001085)2.50626439
63Gastrointestinal infarctions (HP:0005244)2.50321497
64Upper motor neuron abnormality (HP:0002127)2.48085188
65Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45336956
66Neurodegeneration (HP:0002180)2.43355378
67Elevated erythrocyte sedimentation rate (HP:0003565)2.42810632
68Osteomyelitis (HP:0002754)2.39445836
69Curly hair (HP:0002212)2.35173892
70Keratoconjunctivitis (HP:0001096)2.34653956
71Abnormal platelet volume (HP:0011876)2.33810187
72Prolonged bleeding time (HP:0003010)2.33774871
73Thyroiditis (HP:0100646)2.32864275
74Bladder neoplasm (HP:0009725)2.32416976
75Bladder carcinoma (HP:0002862)2.32416976
76Amyotrophic lateral sclerosis (HP:0007354)2.29454400
77Vasculitis (HP:0002633)2.27816720
78Leukocytosis (HP:0001974)2.24918654
79Transitional cell carcinoma of the bladder (HP:0006740)2.24702622
80Colitis (HP:0002583)2.21309270
81Increased mean platelet volume (HP:0011877)2.20442592
82Loss of speech (HP:0002371)2.20370819
83Thoracic kyphosis (HP:0002942)2.18039283
84Abnormality of the thoracic spine (HP:0100711)2.17201500
85Meningitis (HP:0001287)2.13598693
86Increased CSF protein (HP:0002922)2.11963668
87Epistaxis (HP:0000421)2.10114750
88Distal lower limb amyotrophy (HP:0008944)2.09513140
89Thickened calvaria (HP:0002684)2.09416945
90Overgrowth (HP:0001548)2.08066790
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06486908
92Inflammation of the large intestine (HP:0002037)2.06226308
93Pustule (HP:0200039)2.02810716
94Resting tremor (HP:0002322)2.02002890
95Deep philtrum (HP:0002002)2.01738856
96Termporal pattern (HP:0011008)2.01700835
97Insidious onset (HP:0003587)2.01700835
98Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01111056
99Pulmonary infiltrates (HP:0002113)2.00998208
100Agnosia (HP:0010524)1.99041265
101Lower limb amyotrophy (HP:0007210)1.99031025
102Thoracolumbar scoliosis (HP:0002944)1.98596847
103Apathy (HP:0000741)1.98096624
104Fatigue (HP:0012378)1.97850580
105Broad ribs (HP:0000885)1.96924298
106Large earlobe (HP:0009748)1.96709727
107J-shaped sella turcica (HP:0002680)1.95877231
108Neuronal loss in central nervous system (HP:0002529)1.94529754
109Vertebral arch anomaly (HP:0008438)1.92967794
110Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91492649
111Micronodular cirrhosis (HP:0001413)1.91383685
112Diminished motivation (HP:0000745)1.90896317
113Conjunctival telangiectasia (HP:0000524)1.89868690
114Pathologic fracture (HP:0002756)1.89386376
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.89316460
116Eosinophilia (HP:0001880)1.88968591
117Abnormality of the lumbar spine (HP:0100712)1.88378865
118Basal ganglia calcification (HP:0002135)1.87560081
119Gastrointestinal inflammation (HP:0004386)1.87355965
120Acute myeloid leukemia (HP:0004808)1.87321203
121Spondylolisthesis (HP:0003302)1.86613997
122Arterial tortuosity (HP:0005116)1.85772533
123Urticaria (HP:0001025)1.84622074
124Peripheral demyelination (HP:0011096)1.84430553
125Generalized hypopigmentation (HP:0007513)1.84152868
126Ocular albinism (HP:0001107)1.84024398
127Coarse hair (HP:0002208)1.83896224
128Chest pain (HP:0100749)1.83089143
129Encephalitis (HP:0002383)1.82181290
130Osteolytic defects of the phalanges of the hand (HP:0009771)1.81552230
131Osteolytic defects of the hand bones (HP:0009699)1.81552230
132Hemoptysis (HP:0002105)1.81488021
133Abnormality of T cells (HP:0002843)1.81458153
134Premature loss of primary teeth (HP:0006323)1.79789386
135Neoplasm of the tracheobronchial system (HP:0100552)1.79578343
136Leiomyosarcoma (HP:0100243)1.79157787
137Uterine leiomyosarcoma (HP:0002891)1.79157787
138Albinism (HP:0001022)1.79032687
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77930782
140Abnormality of the frontal sinuses (HP:0002687)1.75400916
141Joint hemorrhage (HP:0005261)1.74948849
142Bone pain (HP:0002653)1.74516014
143Slow saccadic eye movements (HP:0000514)1.74142820
144Frequent falls (HP:0002359)1.73266249
145Narrow palate (HP:0000189)1.72116711
146Cystic hygroma (HP:0000476)1.71306673
147Abnormality of the peritoneum (HP:0002585)1.69474933
148Pelvic girdle muscle weakness (HP:0003749)1.68709097
149Medulloblastoma (HP:0002885)1.68458269
150Amaurosis fugax (HP:0100576)1.67025005
151Relative macrocephaly (HP:0004482)1.66494369
152Orthostatic hypotension (HP:0001278)1.66386040
153Menstrual irregularities (HP:0000858)1.65566616
154Cubitus valgus (HP:0002967)1.64134327
155Ankyloglossia (HP:0010296)1.63881457
156Dilatation of the ascending aorta (HP:0005111)1.63258656
157Vascular tortuosity (HP:0004948)1.62300371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.96242654
2KIT3.66313614
3TAOK33.04998269
4MAP3K142.89406632
5MAP3K132.58843335
6FES2.37490052
7TYK22.36447818
8CAMK1D2.33444458
9IRAK42.10883719
10JAK32.02995169
11TBK11.99923499
12JAK11.99209051
13YES11.98964260
14CAMK1G1.97943553
15SIK21.94601601
16MAP4K11.94523449
17IKBKE1.87415693
18CAMKK21.86651366
19KSR11.85136043
20SCYL21.83363962
21PRPF4B1.76224523
22HCK1.71329797
23TTN1.69972483
24CSF1R1.66769564
25WNK11.55363332
26SYK1.50080640
27PKN21.46280331
28DAPK21.44133114
29TXK1.42562309
30MAP3K101.41594309
31SGK31.40588625
32IRAK31.40262455
33TEC1.36311508
34NLK1.35842630
35IKBKB1.35772019
36MAP2K41.35525384
37TRPM71.35483532
38CAMKK11.34691793
39FGFR31.34111104
40AKT31.25651119
41SGK21.25156424
42IRAK21.24003597
43DYRK31.22736072
44PIK3CG1.22384637
45JAK21.22367583
46NEK91.19852157
47RIPK11.17251485
48CDK121.17098275
49CDK61.14620721
50MAP3K121.12015831
51MAP3K11.10829556
52ITK1.08701591
53IRAK11.07690433
54FGR1.07400594
55TRIB31.03695871
56LCK1.02596558
57MAP3K91.01901402
58STK41.00967451
59MAP2K30.95287808
60PDK10.92732493
61KSR20.92731700
62ZAP700.92372781
63BTK0.89998063
64STK38L0.88535209
65LYN0.87528049
66BCR0.85213256
67SIK30.85085283
68CHUK0.83951453
69PDGFRA0.83778061
70TAOK10.83309806
71CSK0.82101099
72EGFR0.81122653
73SGK10.80270754
74RPS6KA40.79778327
75EEF2K0.78289339
76STK30.78122623
77MAP3K40.77480543
78PRKCH0.76141929
79TGFBR20.75720235
80PIM10.75163769
81MAP3K50.74179760
82PTK60.73599555
83ACVR1B0.72903988
84MARK30.72706074
85PDGFRB0.72663053
86PDPK10.71715684
87GRK70.70034339
88ABL10.68552896
89DYRK1A0.68257706
90MARK20.67185640
91RAF10.66856679
92MAP3K60.66687577
93LATS10.64804159
94EPHB10.64189424
95BLK0.64060070
96DAPK10.62896355
97GRK60.60198646
98MATK0.58523276
99PRKCQ0.57544760
100DYRK1B0.57396022
101RET0.57125011
102CLK10.56957724
103FYN0.55689866
104NEK20.55083445
105DMPK0.54527168
106MAPK70.52330946
107PTK2B0.49890955
108PLK20.49713342
109RPS6KB10.49214715
110CAMK40.48405243
111MELK0.48118029
112SGK4940.47842539
113SGK2230.47842539
114MAP3K20.46486743
115BRD40.45845698
116RPS6KA20.45513221
117ALK0.44407638
118LRRK20.43368323
119PRKAA20.42318958
120ERBB30.41425467
121MAP3K30.41153280
122MAPK100.41071380
123EPHA40.40943345
124HIPK20.39992617
125STK100.38155642
126NEK60.37990517
127BMPR20.37577281
128CDC70.36702427
129PRKCD0.35821964
130CDK90.35011219
131MAPK120.34291604
132STK380.33690602
133STK240.33261403
134TNK20.32266563
135PAK60.32116777

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.48503106
2Osteoclast differentiation_Homo sapiens_hsa043802.48481157
3B cell receptor signaling pathway_Homo sapiens_hsa046622.27475477
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15894397
5Lysosome_Homo sapiens_hsa041421.99854650
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.95983671
7Tuberculosis_Homo sapiens_hsa051521.95501229
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.89872751
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87138365
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79473347
11Staphylococcus aureus infection_Homo sapiens_hsa051501.78031489
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69329525
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67491680
14Measles_Homo sapiens_hsa051621.59464270
15Phagosome_Homo sapiens_hsa041451.49464774
16Chemokine signaling pathway_Homo sapiens_hsa040621.45859390
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40821075
18Chronic myeloid leukemia_Homo sapiens_hsa052201.38302621
19Toxoplasmosis_Homo sapiens_hsa051451.37896902
20TNF signaling pathway_Homo sapiens_hsa046681.35890587
21Type II diabetes mellitus_Homo sapiens_hsa049301.34373400
22Pertussis_Homo sapiens_hsa051331.34230429
23Influenza A_Homo sapiens_hsa051641.33612823
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30646683
25Malaria_Homo sapiens_hsa051441.30355714
26Other glycan degradation_Homo sapiens_hsa005111.29433251
27Apoptosis_Homo sapiens_hsa042101.29073112
28ErbB signaling pathway_Homo sapiens_hsa040121.29047102
29Rheumatoid arthritis_Homo sapiens_hsa053231.26753237
30Pancreatic cancer_Homo sapiens_hsa052121.25604010
31T cell receptor signaling pathway_Homo sapiens_hsa046601.22120773
32Colorectal cancer_Homo sapiens_hsa052101.22065646
33Platelet activation_Homo sapiens_hsa046111.17972048
34Olfactory transduction_Homo sapiens_hsa047401.17346493
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16404458
36Caffeine metabolism_Homo sapiens_hsa002321.15927675
37Hepatitis B_Homo sapiens_hsa051611.14299081
38Non-small cell lung cancer_Homo sapiens_hsa052231.09335224
39Prostate cancer_Homo sapiens_hsa052151.09257012
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07590113
41Hematopoietic cell lineage_Homo sapiens_hsa046401.07313526
42Salmonella infection_Homo sapiens_hsa051321.05461744
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.04933253
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.04494434
45Glioma_Homo sapiens_hsa052141.04177996
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.03946535
47Thyroid cancer_Homo sapiens_hsa052161.02798433
48Shigellosis_Homo sapiens_hsa051311.02757573
49Legionellosis_Homo sapiens_hsa051341.02238156
50Collecting duct acid secretion_Homo sapiens_hsa049661.02016056
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01694156
52mTOR signaling pathway_Homo sapiens_hsa041501.00841113
53Acute myeloid leukemia_Homo sapiens_hsa052211.00820328
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97967257
55Proteoglycans in cancer_Homo sapiens_hsa052050.95208474
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94576485
57Allograft rejection_Homo sapiens_hsa053300.93088289
58Asthma_Homo sapiens_hsa053100.91514851
59Inositol phosphate metabolism_Homo sapiens_hsa005620.91057846
60Hepatitis C_Homo sapiens_hsa051600.89237689
61Antigen processing and presentation_Homo sapiens_hsa046120.86927847
62Prolactin signaling pathway_Homo sapiens_hsa049170.86793837
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86491335
64Graft-versus-host disease_Homo sapiens_hsa053320.86071672
65Adherens junction_Homo sapiens_hsa045200.85973761
66Herpes simplex infection_Homo sapiens_hsa051680.84249352
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82962402
68Dorso-ventral axis formation_Homo sapiens_hsa043200.82647267
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.82633171
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82441530
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.82119743
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.81678906
73VEGF signaling pathway_Homo sapiens_hsa043700.78676301
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78343221
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78175278
76Primary immunodeficiency_Homo sapiens_hsa053400.77412359
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75485203
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74777645
79Focal adhesion_Homo sapiens_hsa045100.74314794
80Estrogen signaling pathway_Homo sapiens_hsa049150.73950979
81Rap1 signaling pathway_Homo sapiens_hsa040150.73915079
82Insulin resistance_Homo sapiens_hsa049310.73540250
83Synaptic vesicle cycle_Homo sapiens_hsa047210.73079640
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72306678
85Long-term depression_Homo sapiens_hsa047300.71781380
86Endocytosis_Homo sapiens_hsa041440.70845448
87FoxO signaling pathway_Homo sapiens_hsa040680.70398369
88Ras signaling pathway_Homo sapiens_hsa040140.69780013
89Lysine degradation_Homo sapiens_hsa003100.69770932
90Small cell lung cancer_Homo sapiens_hsa052220.68327474
91Amoebiasis_Homo sapiens_hsa051460.67991504
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67019320
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66968859
94Viral myocarditis_Homo sapiens_hsa054160.66513948
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.66163697
96Melanoma_Homo sapiens_hsa052180.65827979
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65533144
98Pathways in cancer_Homo sapiens_hsa052000.64565639
99Type I diabetes mellitus_Homo sapiens_hsa049400.63335149
100Gap junction_Homo sapiens_hsa045400.61647289
101Choline metabolism in cancer_Homo sapiens_hsa052310.61212220
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60944811
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59419420
104Cholinergic synapse_Homo sapiens_hsa047250.58686444
105African trypanosomiasis_Homo sapiens_hsa051430.58021169
106Endometrial cancer_Homo sapiens_hsa052130.57891675
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57665356
108Insulin signaling pathway_Homo sapiens_hsa049100.57502430
109Renal cell carcinoma_Homo sapiens_hsa052110.56560482
110Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56377567
111MicroRNAs in cancer_Homo sapiens_hsa052060.56262061
112HIF-1 signaling pathway_Homo sapiens_hsa040660.56123795
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55882354
114Morphine addiction_Homo sapiens_hsa050320.54877572
115Viral carcinogenesis_Homo sapiens_hsa052030.52452058
116GnRH signaling pathway_Homo sapiens_hsa049120.52010584
117MAPK signaling pathway_Homo sapiens_hsa040100.51989418
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50881436
119HTLV-I infection_Homo sapiens_hsa051660.50705050
120Oxytocin signaling pathway_Homo sapiens_hsa049210.46058952
121Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45505332
122Long-term potentiation_Homo sapiens_hsa047200.45236724

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