OSBPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.22988848
2Golgi transport vesicle coating (GO:0048200)6.22988848
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.23040398
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.23040398
5modulation by symbiont of host immune response (GO:0052553)4.23040398
6positive regulation by symbiont of host defense response (GO:0052509)4.23040398
7modulation by symbiont of host defense response (GO:0052031)4.23040398
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.23040398
9retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.18653913
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.09899214
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.05328879
12negative regulation of cell killing (GO:0031342)3.95964018
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95964018
14regulation of interferon-beta biosynthetic process (GO:0045357)3.90600639
15macrophage activation involved in immune response (GO:0002281)3.74927085
16protein retention in ER lumen (GO:0006621)3.68719741
17detection of other organism (GO:0098543)3.57167751
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.48700814
19response to host immune response (GO:0052572)3.48700814
20COPII vesicle coating (GO:0048208)3.47896532
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.47757700
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.47754740
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44912668
24neutrophil activation (GO:0042119)3.41593235
25neutrophil activation involved in immune response (GO:0002283)3.40192276
26detection of bacterium (GO:0016045)3.38725689
27vesicle coating (GO:0006901)3.37932964
28synaptic vesicle maturation (GO:0016188)3.30471958
29response to host (GO:0075136)3.24223356
30response to host defenses (GO:0052200)3.24223356
31response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24223356
32leukocyte migration involved in inflammatory response (GO:0002523)3.23230008
33positive regulation of nuclease activity (GO:0032075)3.23039152
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.21077232
35NADH metabolic process (GO:0006734)3.16485597
36antigen processing and presentation of endogenous antigen (GO:0019883)3.15545733
37regulation of synaptic vesicle exocytosis (GO:2000300)3.11339504
38detection of external biotic stimulus (GO:0098581)3.10791314
39cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09258828
40detection of molecule of bacterial origin (GO:0032490)3.08558390
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08532179
42cerebellar Purkinje cell layer development (GO:0021680)3.05337325
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.04069640
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03846779
45desmosome organization (GO:0002934)3.02227642
46antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98626413
47negative regulation of lymphocyte mediated immunity (GO:0002707)2.96689016
48endoplasmic reticulum unfolded protein response (GO:0030968)2.93519185
49ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.93463481
50establishment of skin barrier (GO:0061436)2.88863609
51regulation of B cell receptor signaling pathway (GO:0050855)2.88554132
52granulocyte activation (GO:0036230)2.88362357
53macrophage activation (GO:0042116)2.88218146
54negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87152935
55ER-nucleus signaling pathway (GO:0006984)2.86950686
56hepatocyte apoptotic process (GO:0097284)2.86402766
57microglial cell activation (GO:0001774)2.85614532
58interferon-gamma secretion (GO:0072643)2.85417425
59valine metabolic process (GO:0006573)2.84939279
60cellular response to unfolded protein (GO:0034620)2.84915782
61response to pheromone (GO:0019236)2.83766203
62activation of protein kinase A activity (GO:0034199)2.83593034
63regulation of nuclease activity (GO:0032069)2.83312801
64tricarboxylic acid metabolic process (GO:0072350)2.82658186
65negative regulation of cAMP-mediated signaling (GO:0043951)2.80289077
66oxaloacetate metabolic process (GO:0006107)2.79935089
67cell communication by electrical coupling (GO:0010644)2.79563574
68peptidyl-tyrosine autophosphorylation (GO:0038083)2.79225170
69succinate metabolic process (GO:0006105)2.78920512
70cell communication involved in cardiac conduction (GO:0086065)2.78843515
71neutrophil mediated immunity (GO:0002446)2.78202775
72protein targeting to Golgi (GO:0000042)2.77680087
73toxin metabolic process (GO:0009404)2.76535424
74positive regulation of Cdc42 GTPase activity (GO:0043089)2.75571733
75positive regulation of gamma-delta T cell activation (GO:0046645)2.75500303
76response to interleukin-15 (GO:0070672)2.74647749
77cellular response to topologically incorrect protein (GO:0035967)2.73697930
78leukocyte aggregation (GO:0070486)2.71853378
792-oxoglutarate metabolic process (GO:0006103)2.69360616
80tricarboxylic acid cycle (GO:0006099)2.69204693
81regulation of water loss via skin (GO:0033561)2.69040828
82regulation of synaptic vesicle transport (GO:1902803)2.67278004
83cellular response to interleukin-15 (GO:0071350)2.65701841
84positive regulation of vesicle fusion (GO:0031340)2.65248686
85insulin secretion (GO:0030073)2.64656069
86growth hormone secretion (GO:0030252)2.62308096
87synaptic vesicle exocytosis (GO:0016079)2.62103814
88macroautophagy (GO:0016236)2.61962270
89negative regulation of myotube differentiation (GO:0010832)2.59975539
90ER overload response (GO:0006983)2.57802405
91negative regulation of glycoprotein biosynthetic process (GO:0010561)2.57729443
92detection of biotic stimulus (GO:0009595)2.56954030
93intra-Golgi vesicle-mediated transport (GO:0006891)2.55489683
94exocrine pancreas development (GO:0031017)2.55464780
95neurotransmitter secretion (GO:0007269)2.55333932
96sodium ion export (GO:0071436)2.54467272
97sequestering of metal ion (GO:0051238)2.53875236
98sulfur amino acid catabolic process (GO:0000098)2.52793377
99negative regulation of B cell mediated immunity (GO:0002713)2.51836736
100negative regulation of immunoglobulin mediated immune response (GO:0002890)2.51836736
101response to endoplasmic reticulum stress (GO:0034976)2.50707000
102protein maturation by protein folding (GO:0022417)2.50345172
103endocrine pancreas development (GO:0031018)2.50197321
104lysine catabolic process (GO:0006554)2.49572443
105lysine metabolic process (GO:0006553)2.49572443
106regulation of clathrin-mediated endocytosis (GO:2000369)2.49022944
107glutamate secretion (GO:0014047)2.48736001
108regulation of female receptivity (GO:0045924)2.47501964
109alpha-linolenic acid metabolic process (GO:0036109)2.46093909
110regulation of ARF protein signal transduction (GO:0032012)2.45868684
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45656224
112L-phenylalanine catabolic process (GO:0006559)2.45656224
113peptide hormone processing (GO:0016486)2.44018572
114potassium ion homeostasis (GO:0055075)2.42709077
115maintenance of gastrointestinal epithelium (GO:0030277)2.42479558
116cellular potassium ion homeostasis (GO:0030007)2.42265146
117myeloid leukocyte mediated immunity (GO:0002444)2.42032390
118retrograde transport, vesicle recycling within Golgi (GO:0000301)2.41878126
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.41480310
120synaptic vesicle docking involved in exocytosis (GO:0016081)2.41408722
121locomotory exploration behavior (GO:0035641)2.40909921
122UDP-N-acetylglucosamine metabolic process (GO:0006047)2.40703583
123regulation of beta-amyloid formation (GO:1902003)2.40244716
124establishment of protein localization to Golgi (GO:0072600)2.39250648
125response to peptidoglycan (GO:0032494)2.38572047
126regulation of cholesterol homeostasis (GO:2000188)2.38129595
127regulation of synapse structural plasticity (GO:0051823)2.38010117
128negative regulation of leukocyte mediated immunity (GO:0002704)2.37935359
129detection of calcium ion (GO:0005513)2.37435558
130beta-amyloid metabolic process (GO:0050435)2.37213975
131positive regulation of insulin secretion (GO:0032024)2.37076799
132positive regulation of cellular amide metabolic process (GO:0034250)2.36854174
133cysteine metabolic process (GO:0006534)2.36573174
134negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34854244
135cellular response to glucagon stimulus (GO:0071377)2.34145337
136cellular extravasation (GO:0045123)2.33262059
137regulation of amyloid precursor protein catabolic process (GO:1902991)2.32323675
138regulation of gamma-delta T cell activation (GO:0046643)2.31687155
139negative regulation of microtubule polymerization (GO:0031115)2.31474884
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.31308056
141L-phenylalanine metabolic process (GO:0006558)2.31308056
142phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.31149698
143intestinal epithelial cell development (GO:0060576)2.30030391
144layer formation in cerebral cortex (GO:0021819)2.28425460
145production of molecular mediator involved in inflammatory response (GO:0002532)2.28297563
146regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26915393
147vocalization behavior (GO:0071625)2.24978012
148superoxide anion generation (GO:0042554)2.24968108
1494-hydroxyproline metabolic process (GO:0019471)2.24870654
150positive regulation of regulated secretory pathway (GO:1903307)2.24840586
151regulation of insulin secretion (GO:0050796)2.24798814
152regulation of regulated secretory pathway (GO:1903305)2.24687541
153transcytosis (GO:0045056)2.24290811
154myeloid cell activation involved in immune response (GO:0002275)2.24245459
155peptide secretion (GO:0002790)2.22876080
156actin filament polymerization (GO:0030041)2.22223474
157response to unfolded protein (GO:0006986)2.22200772
158positive regulation of histone deacetylation (GO:0031065)2.22150627
159fatty acid beta-oxidation (GO:0006635)2.21389221
160protein localization to Golgi apparatus (GO:0034067)2.21094850
161respiratory burst (GO:0045730)2.21021012
162regulation of mast cell degranulation (GO:0043304)2.19931493
163fatty acid catabolic process (GO:0009062)2.19712626
164intestinal cholesterol absorption (GO:0030299)2.19710729
165Golgi organization (GO:0007030)2.18583959
166relaxation of cardiac muscle (GO:0055119)2.18294422
167peptidyl-asparagine modification (GO:0018196)2.18224571
168response to topologically incorrect protein (GO:0035966)2.18213959
169membrane repolarization during action potential (GO:0086011)2.17232161
170peptide hormone secretion (GO:0030072)2.17054711
171branched-chain amino acid metabolic process (GO:0009081)2.16997997
172mating behavior (GO:0007617)2.16965672
173positive regulation of exocytosis (GO:0045921)2.16822382
174regulation of leukocyte degranulation (GO:0043300)2.15058079
175regulation of cellular amide metabolic process (GO:0034248)2.14842115
176bundle of His cell to Purkinje myocyte communication (GO:0086069)2.14340843
177positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.13205184
178negative regulation of toll-like receptor signaling pathway (GO:0034122)2.12079435
179regulation of myeloid leukocyte mediated immunity (GO:0002886)2.11920594
180regulation of autophagic vacuole assembly (GO:2000785)2.10399013
181regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.09118042
182germinal center formation (GO:0002467)2.08878455
183regulation of gamma-delta T cell differentiation (GO:0045586)2.08393550
184negative regulation of interleukin-6 production (GO:0032715)2.07491709
185positive regulation of Rap GTPase activity (GO:0032854)2.07297045
186negative regulation of smooth muscle contraction (GO:0045986)2.05734467
187relaxation of smooth muscle (GO:0044557)2.05369058
188response to type I interferon (GO:0034340)2.04931102
189negative regulation of T-helper cell differentiation (GO:0045623)2.04267291
190negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.04267291
191regulation of mast cell activation (GO:0033003)2.04123724
192activated T cell proliferation (GO:0050798)2.03457808
193regulation of mast cell activation involved in immune response (GO:0033006)2.03300102
194dendritic cell migration (GO:0036336)2.03279321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.23278997
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97616357
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.73868973
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.62170905
5EZH2_22144423_ChIP-Seq_EOC_Human2.54182206
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36043097
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24252454
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23326542
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.17276679
10CLOCK_20551151_ChIP-Seq_293T_Human2.12665211
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.11172366
12* LXR_22158963_ChIP-Seq_LIVER_Mouse2.09433471
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05921800
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.97617818
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.91677226
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85884976
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.82476165
18IRF8_21731497_ChIP-ChIP_J774_Mouse1.78414681
19DROSHA_22980978_ChIP-Seq_HELA_Human1.77115949
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75446602
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.74888225
22* RARB_27405468_Chip-Seq_BRAIN_Mouse1.73950052
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72085368
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68234255
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.67126488
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.65898588
27SPI1_23127762_ChIP-Seq_K562_Human1.65739987
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65628656
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.65298187
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64868605
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61956297
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.60427884
33NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58301889
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.57458713
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55679692
36REST_21632747_ChIP-Seq_MESCs_Mouse1.54756502
37ZNF274_21170338_ChIP-Seq_K562_Hela1.48952338
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47842416
39RUNX_20019798_ChIP-Seq_JUKART_Human1.47687532
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40239522
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39850942
42KDM2B_26808549_Chip-Seq_K562_Human1.39744883
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38886009
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38558537
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37206616
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.36832325
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36812571
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.36010098
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.35251125
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34638859
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34462374
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33629467
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32934887
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32062980
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31264211
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.30730259
57TCF7_22412390_ChIP-Seq_EML_Mouse1.30151629
58* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.29968639
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29479946
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28307014
61* LXR_22292898_ChIP-Seq_THP-1_Human1.28084981
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.27788459
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27068640
64ZNF263_19887448_ChIP-Seq_K562_Human1.25307509
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25177408
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25030889
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24485616
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23070753
69SCL_19346495_ChIP-Seq_HPC-7_Human1.22365753
70GATA1_22025678_ChIP-Seq_K562_Human1.20280963
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20195432
72GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.19828861
73CREB1_26743006_Chip-Seq_LNCaP_Human1.18906678
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15560868
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15014173
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.13337684
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12418450
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11092114
79VDR_24787735_ChIP-Seq_THP-1_Human1.11061331
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10837566
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.09947719
82GATA2_19941826_ChIP-Seq_K562_Human1.09820894
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09692905
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08684498
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.08310633
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08105838
87RACK7_27058665_Chip-Seq_MCF-7_Human1.07859621
88JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07604916
89RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07503543
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07503543
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07461478
92KDM2B_26808549_Chip-Seq_DND41_Human1.06693108
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05812924
94SOX2_20726797_ChIP-Seq_SW620_Human1.05725436
95* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05473082
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05253610
97* TET1_21490601_ChIP-Seq_MESCs_Mouse1.05070375
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04949996
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.03718852
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03599807
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02407662
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.02029131
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01494593
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00935917
105VDR_24763502_ChIP-Seq_THP-1_Human0.99506159
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.99465387
107* SMC4_20622854_ChIP-Seq_HELA_Human0.99219624
108GATA1_19941826_ChIP-Seq_K562_Human0.99173224
109* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99114363
110* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98946785
111AHR_22903824_ChIP-Seq_MCF-7_Human0.98691847
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.98210375
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.98210375
114* TP63_22573176_ChIP-Seq_HFKS_Human0.97436373
115* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97301455
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96119621
117FOXH1_21741376_ChIP-Seq_ESCs_Human0.96099939
118* EP300_21415370_ChIP-Seq_HL-1_Mouse0.95526840
119* KLF5_25053715_ChIP-Seq_YYC3_Human0.95151693
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94962637
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94847114
122BCOR_27268052_Chip-Seq_Bcells_Human0.94688181
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94648608
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.94138753
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93487801
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92964059
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92521003
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92521003
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92256898
130SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91896644
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91683106
132TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91480282
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90716808
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90588638
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90000394
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.89838546
137BCAT_22108803_ChIP-Seq_LS180_Human0.89728532
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89325026
139KLF4_19829295_ChIP-Seq_ESCs_Human0.88900150
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88841381
141AR_19668381_ChIP-Seq_PC3_Human0.88779404
142GATA6_25053715_ChIP-Seq_YYC3_Human0.87543418
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87307743
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.87225719
145EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86567044
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.85411533
147ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85220991
148GATA4_25053715_ChIP-Seq_YYC3_Human0.85055206
149CTCF_27219007_Chip-Seq_Bcells_Human0.84712035
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84419631
151ATF3_27146783_Chip-Seq_COLON_Human0.84269203
152GATA3_27048872_Chip-Seq_THYMUS_Human0.84120077
153P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83967919
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83496000
155* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83077008
156ARNT_22903824_ChIP-Seq_MCF-7_Human0.82989182
157* BCL6_27268052_Chip-Seq_Bcells_Human0.82781749
158OCT4_19829295_ChIP-Seq_ESCs_Human0.82443694
159IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81861472
160* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81227369
161* GATA3_24758297_ChIP-Seq_MCF-7_Human0.81069086
162P68_20966046_ChIP-Seq_HELA_Human0.80463186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.91294858
2MP0003724_increased_susceptibility_to3.73821442
3MP0009780_abnormal_chondrocyte_physiolo3.57263763
4MP0004381_abnormal_hair_follicle3.56494484
5MP0002909_abnormal_adrenal_gland3.26796779
6MP0002139_abnormal_hepatobiliary_system3.14649194
7MP0008260_abnormal_autophagy2.90481736
8MP0000013_abnormal_adipose_tissue2.78744710
9MP0010386_abnormal_urinary_bladder2.71881997
10MP0010234_abnormal_vibrissa_follicle2.64219498
11MP0005365_abnormal_bile_salt2.59393051
12MP0003191_abnormal_cellular_cholesterol2.54042624
13MP0004043_abnormal_pH_regulation2.50932879
14MP0003878_abnormal_ear_physiology2.49919622
15MP0005377_hearing/vestibular/ear_phenot2.49919622
16MP0001666_abnormal_nutrient_absorption2.23074572
17MP0002653_abnormal_ependyma_morphology2.22690354
18MP0003787_abnormal_imprinting2.22624008
19MP0002132_abnormal_respiratory_system2.22609653
20MP0005220_abnormal_exocrine_pancreas2.10588516
21MP0002822_catalepsy2.10159585
22MP0005451_abnormal_body_composition2.06412819
23MP0004859_abnormal_synaptic_plasticity2.05905430
24MP0003436_decreased_susceptibility_to2.05720181
25MP0005085_abnormal_gallbladder_physiolo2.01269477
26MP0003329_amyloid_beta_deposits2.00626113
27MP0003183_abnormal_peptide_metabolism1.95657403
28MP0001944_abnormal_pancreas_morphology1.95442042
29MP0002877_abnormal_melanocyte_morpholog1.92544990
30MP0003300_gastrointestinal_ulcer1.92524570
31MP0003195_calcinosis1.88052018
32MP0002693_abnormal_pancreas_physiology1.79555491
33MP0008961_abnormal_basal_metabolism1.79149974
34MP0003868_abnormal_feces_composition1.75405831
35MP0003635_abnormal_synaptic_transmissio1.75162053
36MP0003122_maternal_imprinting1.74427124
37MP0004130_abnormal_muscle_cell1.70999021
38MP0002078_abnormal_glucose_homeostasis1.70853850
39MP0005083_abnormal_biliary_tract1.68233936
40MP0008004_abnormal_stomach_pH1.66338055
41MP0004270_analgesia1.62295086
42MP0002419_abnormal_innate_immunity1.57832523
43MP0000003_abnormal_adipose_tissue1.57430884
44MP0005075_abnormal_melanosome_morpholog1.56613207
45MP0003283_abnormal_digestive_organ1.54946718
46MP0005058_abnormal_lysosome_morphology1.54881094
47MP0002796_impaired_skin_barrier1.52858839
48MP0010329_abnormal_lipoprotein_level1.52772942
49MP0010678_abnormal_skin_adnexa1.47580246
50MP0005409_darkened_coat_color1.47157967
51MP0005025_abnormal_response_to1.46398890
52MP0001800_abnormal_humoral_immune1.46376116
53MP0005360_urolithiasis1.46200037
54MP0008875_abnormal_xenobiotic_pharmacok1.44403970
55MP0001851_eye_inflammation1.43869402
56MP0004264_abnormal_extraembryonic_tissu1.43162189
57MP0001765_abnormal_ion_homeostasis1.42591918
58MP0000371_diluted_coat_color1.42363047
59MP0003303_peritoneal_inflammation1.41955535
60MP0002118_abnormal_lipid_homeostasis1.38473394
61MP0000015_abnormal_ear_pigmentation1.37784891
62MP0000427_abnormal_hair_cycle1.35987283
63MP0003045_fibrosis1.34374491
64MP0003252_abnormal_bile_duct1.33865667
65MP0000383_abnormal_hair_follicle1.33721792
66MP0005535_abnormal_body_temperature1.33631860
67MP0001756_abnormal_urination1.33625307
68MP0005387_immune_system_phenotype1.33181512
69MP0001790_abnormal_immune_system1.33181512
70MP0000372_irregular_coat_pigmentation1.31950965
71MP0004947_skin_inflammation1.31035811
72MP0002063_abnormal_learning/memory/cond1.29009275
73MP0006072_abnormal_retinal_apoptosis1.28980614
74MP0003172_abnormal_lysosome_physiology1.28013237
75MP0005332_abnormal_amino_acid1.24734587
76MP0009643_abnormal_urine_homeostasis1.24562665
77MP0001664_abnormal_digestion1.24551458
78MP0002733_abnormal_thermal_nociception1.24340412
79MP0001501_abnormal_sleep_pattern1.22357022
80MP0000685_abnormal_immune_system1.21620655
81MP0005248_abnormal_Harderian_gland1.21263840
82MP0005646_abnormal_pituitary_gland1.19605191
83MP0005670_abnormal_white_adipose1.19592798
84MP0002734_abnormal_mechanical_nocicepti1.19097474
85MP0002723_abnormal_immune_serum1.18494707
86MP0003953_abnormal_hormone_level1.17333906
87MP0002098_abnormal_vibrissa_morphology1.15259705
88MP0004036_abnormal_muscle_relaxation1.15251929
89MP0001970_abnormal_pain_threshold1.12676634
90MP0001819_abnormal_immune_cell1.11968487
91MP0000604_amyloidosis1.11898470
92MP0002420_abnormal_adaptive_immunity1.11527964
93MP0009785_altered_susceptibility_to1.11121532
94MP0003879_abnormal_hair_cell1.10865235
95MP0010155_abnormal_intestine_physiology1.10426180
96MP0002452_abnormal_antigen_presenting1.10251384
97MP0005187_abnormal_penis_morphology1.09877169
98MP0005408_hypopigmentation1.09762061
99MP0004484_altered_response_of1.09339492
100MP0000747_muscle_weakness1.08405119
101MP0005464_abnormal_platelet_physiology1.08144021
102MP0004084_abnormal_cardiac_muscle1.07785397
103MP0002064_seizures1.07288592
104MP0004885_abnormal_endolymph1.06722345
105MP0000751_myopathy1.06091637
106MP0001533_abnormal_skeleton_physiology1.06086514
107MP0003763_abnormal_thymus_physiology1.04806954
108MP0004215_abnormal_myocardial_fiber1.04360347
109MP0000465_gastrointestinal_hemorrhage1.02400173
110MP0005636_abnormal_mineral_homeostasis1.02166324
111MP0005375_adipose_tissue_phenotype1.01926999
112MP0005448_abnormal_energy_balance1.01779685
113MP0005671_abnormal_response_to1.01762848
114MP0008569_lethality_at_weaning1.01658398
115MP0003453_abnormal_keratinocyte_physiol1.01031970
116MP0002277_abnormal_respiratory_mucosa0.99830314
117MP0002090_abnormal_vision0.99805291
118MP0002876_abnormal_thyroid_physiology0.99627388
119MP0004924_abnormal_behavior0.97227036
120MP0005386_behavior/neurological_phenoty0.97227036
121MP0002557_abnormal_social/conspecific_i0.96915147
122MP0002234_abnormal_pharynx_morphology0.95807619
123MP0009745_abnormal_behavioral_response0.95661111
124MP0005000_abnormal_immune_tolerance0.95467758
125MP0003123_paternal_imprinting0.95267320
126MP0002928_abnormal_bile_duct0.93656236
127MP0004085_abnormal_heartbeat0.92249054
128MP0003633_abnormal_nervous_system0.92238802
129MP0001845_abnormal_inflammatory_respons0.92069176
130MP0001502_abnormal_circadian_rhythm0.91938214
131MP0009046_muscle_twitch0.91483946
132MP0002272_abnormal_nervous_system0.91163481
133MP0001984_abnormal_olfaction0.90906865
134MP0004883_abnormal_blood_vessel0.90416014
135MP0003690_abnormal_glial_cell0.89768577
136MP0000462_abnormal_digestive_system0.89133158
137MP0002896_abnormal_bone_mineralization0.89062208
138MP0003959_abnormal_lean_body0.88984661
139MP0000230_abnormal_systemic_arterial0.88767721
140MP0003656_abnormal_erythrocyte_physiolo0.87369623
141MP0002971_abnormal_brown_adipose0.87026611
142MP0003646_muscle_fatigue0.86423355
143MP0002269_muscular_atrophy0.85336847
144MP0005310_abnormal_salivary_gland0.84157535
145MP0005319_abnormal_enzyme/_coenzyme0.82589036
146MP0002572_abnormal_emotion/affect_behav0.82226899
147MP0004858_abnormal_nervous_system0.81972525
148MP0003137_abnormal_impulse_conducting0.81805369
149MP0006276_abnormal_autonomic_nervous0.81536992
150MP0000609_abnormal_liver_physiology0.81389692
151MP0002069_abnormal_eating/drinking_beha0.81037943
152MP0006082_CNS_inflammation0.80440874
153MP0000470_abnormal_stomach_morphology0.80248547
154MP0003705_abnormal_hypodermis_morpholog0.79659427
155MP0000377_abnormal_hair_follicle0.79257787
156MP0005666_abnormal_adipose_tissue0.79138042
157MP0001485_abnormal_pinna_reflex0.78333083
158MP0005334_abnormal_fat_pad0.77667303
159MP0003866_abnormal_defecation0.77007887
160MP0000367_abnormal_coat/_hair0.76814130
161MP0000716_abnormal_immune_system0.76338278
162MP0002405_respiratory_system_inflammati0.76147616
163MP0003638_abnormal_response/metabolism_0.75987934
164MP0004811_abnormal_neuron_physiology0.75180084
165MP0001835_abnormal_antigen_presentation0.75166769
166MP0004019_abnormal_vitamin_homeostasis0.73895723
167MP0009115_abnormal_fat_cell0.73390785
168MP0001486_abnormal_startle_reflex0.70285701
169MP0008872_abnormal_physiological_respon0.69193301
170MP0005397_hematopoietic_system_phenotyp0.69001302
171MP0001545_abnormal_hematopoietic_system0.69001302
172MP0008874_decreased_physiological_sensi0.67824992
173MP0000920_abnormal_myelination0.67356967
174MP0002148_abnormal_hypersensitivity_rea0.67009786
175MP0003828_pulmonary_edema0.66365488

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.19525020
2Ketoacidosis (HP:0001993)3.96309559
3Hypoglycemic coma (HP:0001325)3.94928181
4Recurrent bacterial skin infections (HP:0005406)3.78474193
5Recurrent abscess formation (HP:0002722)3.62183099
6Abnormality of macrophages (HP:0004311)3.61130297
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.56710140
8Orchitis (HP:0100796)3.54282324
9Visual hallucinations (HP:0002367)3.52150637
10Recurrent gram-negative bacterial infections (HP:0005420)3.50364863
11Increased IgE level (HP:0003212)3.41622864
12Gastrointestinal infarctions (HP:0005244)3.41230453
13Optic neuritis (HP:0100653)3.34812354
14Retrobulbar optic neuritis (HP:0100654)3.34812354
15Gout (HP:0001997)3.34457724
16Generalized aminoaciduria (HP:0002909)3.32656261
17Myositis (HP:0100614)3.31016531
18Hyperinsulinemic hypoglycemia (HP:0000825)3.29761135
19Ketosis (HP:0001946)3.26356703
20Hyperglycemia (HP:0003074)3.18635354
21Hypoglycemic seizures (HP:0002173)3.10728886
22Agitation (HP:0000713)3.09450443
23Hypochromic microcytic anemia (HP:0004840)3.07999051
24Gingivitis (HP:0000230)2.94210106
25Pheochromocytoma (HP:0002666)2.93213287
26Keratoconjunctivitis sicca (HP:0001097)2.89063610
27Subacute progressive viral hepatitis (HP:0006572)2.83352511
28Symptomatic seizures (HP:0011145)2.78717773
29Ocular albinism (HP:0001107)2.74064098
30Hypochromic anemia (HP:0001931)2.69527351
31Keratoconjunctivitis (HP:0001096)2.68644077
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68533773
33Hypothermia (HP:0002045)2.64412938
34Dysostosis multiplex (HP:0000943)2.63244525
35Curly hair (HP:0002212)2.61050951
36Stomatitis (HP:0010280)2.60801316
37Late onset (HP:0003584)2.60445439
38Gingival bleeding (HP:0000225)2.60173086
39Ventricular fibrillation (HP:0001663)2.55914634
40Myoglobinuria (HP:0002913)2.55899406
41Prolonged bleeding time (HP:0003010)2.55334599
42Micronodular cirrhosis (HP:0001413)2.52839698
43Mucopolysacchariduria (HP:0008155)2.52241114
44Urinary glycosaminoglycan excretion (HP:0003541)2.52241114
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.50528564
46Insulin-resistant diabetes mellitus (HP:0000831)2.49571558
47Neuroendocrine neoplasm (HP:0100634)2.42975724
48Oligomenorrhea (HP:0000876)2.42577984
49Iris hypopigmentation (HP:0007730)2.42363102
50Hyperactive renin-angiotensin system (HP:0000841)2.42343417
51Right ventricular cardiomyopathy (HP:0011663)2.41973168
52Abnormality of nail color (HP:0100643)2.39004645
53Lip pit (HP:0100267)2.37784713
54Abnormality of the intrinsic pathway (HP:0010989)2.34380152
55Palpitations (HP:0001962)2.32470582
56Abnormality of polysaccharide metabolism (HP:0011012)2.32354565
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.32354565
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.32354565
59Bundle branch block (HP:0011710)2.30355230
60Growth hormone excess (HP:0000845)2.26205291
61Pustule (HP:0200039)2.25065680
62Aplasia/Hypoplasia of the macula (HP:0008059)2.24789925
63Urticaria (HP:0001025)2.24476735
64Recurrent skin infections (HP:0001581)2.22555721
65Abnormality of endocrine pancreas physiology (HP:0012093)2.21901371
66Abnormality of the pancreatic islet cells (HP:0006476)2.21901371
67EEG with generalized epileptiform discharges (HP:0011198)2.20343522
68Syncope (HP:0001279)2.20112198
69Decreased circulating renin level (HP:0003351)2.20093546
70Central scotoma (HP:0000603)2.18395908
71Mediastinal lymphadenopathy (HP:0100721)2.18013374
72Hypsarrhythmia (HP:0002521)2.16829798
73Peritonitis (HP:0002586)2.14195062
74Abnormality of purine metabolism (HP:0004352)2.13730390
75Long toe (HP:0010511)2.13613897
76Abnormality of fatty-acid metabolism (HP:0004359)2.13606920
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13564394
78Anxiety (HP:0000739)2.13455820
79Amyloidosis (HP:0011034)2.13137601
80Episodic fever (HP:0001954)2.12619992
81Obstructive lung disease (HP:0006536)2.09948982
82Chronic obstructive pulmonary disease (HP:0006510)2.09948982
83Epileptiform EEG discharges (HP:0011182)2.07848223
84Concave nail (HP:0001598)2.04092453
85Recurrent fungal infections (HP:0002841)2.02279695
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.01600335
87Hypoplasia of the fovea (HP:0007750)1.99603063
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.99603063
89Palmoplantar hyperkeratosis (HP:0000972)1.99131009
90Abnormality of calcium-phosphate metabolism (HP:0100530)1.99123870
91Papilledema (HP:0001085)1.98973498
92Chest pain (HP:0100749)1.98149369
93Thick nail (HP:0001805)1.97835165
94Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97675000
95Depression (HP:0000716)1.97404464
96Hyperglycinuria (HP:0003108)1.95729398
97Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95289401
98Hyperkalemia (HP:0002153)1.94973145
99Prolonged QT interval (HP:0001657)1.94291336
100Insulin resistance (HP:0000855)1.92418955
101Sudden death (HP:0001699)1.92177486
102Increased cerebral lipofuscin (HP:0011813)1.92111523
103Myokymia (HP:0002411)1.90733044
104Hypokalemia (HP:0002900)1.90518222
105Ankle clonus (HP:0011448)1.89840440
106Resting tremor (HP:0002322)1.88772570
107Macroorchidism (HP:0000053)1.88389958
108Focal seizures (HP:0007359)1.87612924
109Xanthomatosis (HP:0000991)1.87078265
110Elevated erythrocyte sedimentation rate (HP:0003565)1.87060656
111Abnormal social behavior (HP:0012433)1.85986209
112Impaired social interactions (HP:0000735)1.85986209
113Vasculitis (HP:0002633)1.85261367
114Abnormality of pain sensation (HP:0010832)1.85113258
115Impaired pain sensation (HP:0007328)1.85113258
116Conjunctival hamartoma (HP:0100780)1.84979022
117Hyperparathyroidism (HP:0000843)1.84977703
118Increased neuronal autofluorescent lipopigment (HP:0002074)1.84971602
119Gangrene (HP:0100758)1.84703683
120Abnormality of renin-angiotensin system (HP:0000847)1.84578291
121Inflammation of the large intestine (HP:0002037)1.84059825
122Hypercortisolism (HP:0001578)1.83429335
123Global brain atrophy (HP:0002283)1.82651669
124Abnormality of chloride homeostasis (HP:0011422)1.82567692
125Chronic diarrhea (HP:0002028)1.82179097
126Supranuclear gaze palsy (HP:0000605)1.81084027
127Arterial thrombosis (HP:0004420)1.80642576
128Restlessness (HP:0000711)1.80359461
129Plantar hyperkeratosis (HP:0007556)1.80228552
130Protuberant abdomen (HP:0001538)1.79542191
131Encephalitis (HP:0002383)1.79445682
132Hyperuricemia (HP:0002149)1.79117866
133Increased purine levels (HP:0004368)1.79117866
134Generalized hypopigmentation (HP:0007513)1.78373282
135Abnormality of transition element cation homeostasis (HP:0011030)1.77140475
136Meningitis (HP:0001287)1.76996951
137Abnormality of potassium homeostasis (HP:0011042)1.76960507
138Sepsis (HP:0100806)1.76946774
139Hamartoma of the eye (HP:0010568)1.74357332
140Severe short stature (HP:0003510)1.74267339
141Torticollis (HP:0000473)1.74234423
142Onion bulb formation (HP:0003383)1.73638021
143Decreased motor nerve conduction velocity (HP:0003431)1.72419473
144Craniofacial dystonia (HP:0012179)1.72326699
145Gastrointestinal inflammation (HP:0004386)1.72301100
146Hyperglycinemia (HP:0002154)1.71921377
147Abdominal distention (HP:0003270)1.71694172
148Deep venous thrombosis (HP:0002625)1.71299352
149Action tremor (HP:0002345)1.71111717
150Abnormality of iron homeostasis (HP:0011031)1.70681678
151Interstitial pulmonary disease (HP:0006530)1.70514491
152Postural tremor (HP:0002174)1.70148131
153Palmar hyperkeratosis (HP:0010765)1.69610798
154Papillary thyroid carcinoma (HP:0002895)1.69560235
155Sensorimotor neuropathy (HP:0007141)1.68365195
156Conjugated hyperbilirubinemia (HP:0002908)1.68296965
157Abnormality of the common coagulation pathway (HP:0010990)1.67769948
158Generalized hypopigmentation of hair (HP:0011358)1.67347001
159Amelogenesis imperfecta (HP:0000705)1.67322863
160Generalized tonic-clonic seizures (HP:0002069)1.67274280
161Osteomyelitis (HP:0002754)1.66360013
162Testicular neoplasm (HP:0010788)1.65936502
163Spontaneous hematomas (HP:0007420)1.65838994
164Exercise-induced myalgia (HP:0003738)1.65717066
165Epistaxis (HP:0000421)1.65509780
166Asymmetric septal hypertrophy (HP:0001670)1.65468230
167Anorexia (HP:0002039)1.64902322
168Atrioventricular block (HP:0001678)1.64354045
169Focal dystonia (HP:0004373)1.63453853
170Drooling (HP:0002307)1.63404716
171Excessive salivation (HP:0003781)1.63404716
172Adrenal overactivity (HP:0002717)1.63366772
173Focal motor seizures (HP:0011153)1.62883102
174Hypotension (HP:0002615)1.61860474
175Cone-rod dystrophy (HP:0000548)1.61721244
176Segmental peripheral demyelination/remyelination (HP:0003481)1.61716204
177Retinal atrophy (HP:0001105)1.61562337
178Increased CSF protein (HP:0002922)1.60503546
179Cellulitis (HP:0100658)1.60468133
180Malnutrition (HP:0004395)1.59766762
181Postural instability (HP:0002172)1.58818231
182Hemoptysis (HP:0002105)1.58744984
183Viral hepatitis (HP:0006562)1.57691820
184Widely spaced teeth (HP:0000687)1.57271431
185Cheilitis (HP:0100825)1.56347183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.66271239
2TRIB33.32560913
3MAP3K23.19985419
4RIPK42.98384604
5BCKDK2.59703594
6ERN12.54373589
7INSRR2.54279920
8IRAK42.29616888
9KSR22.22306969
10EPHA22.20952162
11PKN22.19701519
12MAP3K92.12397172
13GRK62.09263145
14FRK2.00750558
15MAP3K121.96996491
16TNK21.93003767
17MARK11.85943086
18PAK31.75211978
19TAOK31.72957123
20PHKG11.72821335
21PHKG21.72821335
22MAP3K41.72640831
23NTRK31.64782047
24MINK11.64727953
25BLK1.61021713
26SCYL21.57342866
27NTRK11.53992735
28PRKD31.50770122
29MYLK1.50556422
30CSK1.49338766
31RET1.48415620
32RIPK11.48102108
33MAP2K21.46421845
34MST1R1.46036767
35SIK11.40046709
36AKT31.36917297
37CAMKK11.36167588
38MAP4K11.34503788
39TYK21.32386853
40TAOK11.32160611
41MAP2K41.31989545
42IRAK11.28219680
43HIPK21.22914909
44ZAP701.22325612
45MAP3K11.18855533
46FGFR31.18530684
47RPS6KA21.17588244
48FGR1.17037211
49CAMKK21.15715942
50CDK121.14960143
51TESK11.14917040
52MAP2K61.14532222
53DAPK21.13743578
54PIK3CA1.12949924
55PTK21.12458419
56FES1.10295022
57PRKCH1.09513904
58FER1.09460680
59JAK31.08597108
60PTK61.06732411
61NEK61.06531272
62YES11.05681426
63MAP2K11.03646099
64PDK41.03231050
65PDK31.03231050
66PRKD21.01502620
67WNK41.00735728
68CASK0.98768796
69PRKAA20.97237227
70MAP3K130.95373876
71TTN0.95099349
72HCK0.93296838
73PDGFRA0.93075813
74SIK30.92335592
75BTK0.91224732
76PTK2B0.88791988
77CAMK2D0.87175358
78ICK0.85545761
79TESK20.84976383
80SYK0.84836038
81IRAK20.84685675
82NEK10.84100098
83PAK60.82860763
84IKBKE0.82481036
85MARK30.81043914
86EEF2K0.79944007
87PRKAA10.79423354
88STK110.77930839
89PDPK10.76099803
90PINK10.75064067
91LIMK10.73290548
92MAP2K30.72697191
93KSR10.71458010
94MARK20.71401934
95STK380.69552179
96MAP3K30.69336834
97MAP3K60.67495335
98MAPKAPK30.67166551
99PRKG20.66750802
100LRRK20.66547753
101CDK50.66085913
102SGK30.64547121
103FGFR40.62948112
104SMG10.62272760
105ERBB20.62241658
106NTRK20.62127185
107MAP3K70.61615853
108LYN0.60173631
109PDK10.58770277
110MAPK150.58435306
111OXSR10.57352259
112MAP2K70.57349657
113MAP3K110.57195549
114CDC42BPA0.55544542
115TYRO30.55341180
116MAP3K50.54806993
117SGK4940.53203428
118SGK2230.53203428
119DAPK10.51866754
120CSNK1G20.51618954
121LCK0.51058768
122IKBKB0.50869522
123FYN0.50736951
124ACVR1B0.50472064
125CHUK0.49740200
126NLK0.49394142
127DYRK1B0.48499088
128DYRK1A0.47826652
129SIK20.47647071
130JAK20.46219861
131WNK10.45086517
132ILK0.44833721
133PRKCZ0.44008767
134DMPK0.42750410
135EPHA30.41301770
136PASK0.39939691
137PRKD10.39351563
138CAMK10.38980125
139WNK30.38653435
140SGK20.38254122
141JAK10.37782952
142PRKCG0.37755499
143EPHB10.37735119
144PRKCE0.37617024
145PDK20.37352879
146FLT30.32899986
147PRKACG0.32656536
148ERBB30.32073206

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.43494021
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.69583514
3Sulfur metabolism_Homo sapiens_hsa009202.53687628
4Insulin secretion_Homo sapiens_hsa049111.93253789
5Synaptic vesicle cycle_Homo sapiens_hsa047211.92942028
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74776348
7Osteoclast differentiation_Homo sapiens_hsa043801.70575444
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68747506
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66782195
10Fatty acid degradation_Homo sapiens_hsa000711.65112103
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63812500
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63308997
13Nitrogen metabolism_Homo sapiens_hsa009101.56920368
14Vibrio cholerae infection_Homo sapiens_hsa051101.52602276
15Pancreatic secretion_Homo sapiens_hsa049721.50394946
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49560535
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48136687
18Protein export_Homo sapiens_hsa030601.48060994
19Inositol phosphate metabolism_Homo sapiens_hsa005621.47895790
20Propanoate metabolism_Homo sapiens_hsa006401.45428002
21Staphylococcus aureus infection_Homo sapiens_hsa051501.45169143
22Butanoate metabolism_Homo sapiens_hsa006501.43312858
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41548070
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37280004
25Type II diabetes mellitus_Homo sapiens_hsa049301.34497073
26B cell receptor signaling pathway_Homo sapiens_hsa046621.32612930
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31108530
28Tuberculosis_Homo sapiens_hsa051521.29309752
29Fatty acid metabolism_Homo sapiens_hsa012121.28866366
30Olfactory transduction_Homo sapiens_hsa047401.28520800
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.28408158
32GABAergic synapse_Homo sapiens_hsa047271.26495390
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25207670
34Dopaminergic synapse_Homo sapiens_hsa047281.25192280
35Acute myeloid leukemia_Homo sapiens_hsa052211.23538842
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23450889
37Leishmaniasis_Homo sapiens_hsa051401.22503627
38Choline metabolism in cancer_Homo sapiens_hsa052311.21804486
39Non-small cell lung cancer_Homo sapiens_hsa052231.21688139
40Other glycan degradation_Homo sapiens_hsa005111.19421277
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18589868
42Amphetamine addiction_Homo sapiens_hsa050311.15335468
43Circadian entrainment_Homo sapiens_hsa047131.12893865
44VEGF signaling pathway_Homo sapiens_hsa043701.10892660
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.09199470
46Bile secretion_Homo sapiens_hsa049761.07627953
47Chemokine signaling pathway_Homo sapiens_hsa040621.07201208
48Collecting duct acid secretion_Homo sapiens_hsa049661.07125901
49Tryptophan metabolism_Homo sapiens_hsa003801.05928348
50Glucagon signaling pathway_Homo sapiens_hsa049221.05761167
51Pyruvate metabolism_Homo sapiens_hsa006201.05604209
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05272609
53FoxO signaling pathway_Homo sapiens_hsa040681.05086054
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04933845
55Platelet activation_Homo sapiens_hsa046111.04380408
56Glycerolipid metabolism_Homo sapiens_hsa005611.04142154
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03958435
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.02054307
59Cholinergic synapse_Homo sapiens_hsa047251.00003589
60Dorso-ventral axis formation_Homo sapiens_hsa043200.99608256
61Insulin resistance_Homo sapiens_hsa049310.99495544
62Fat digestion and absorption_Homo sapiens_hsa049750.99191731
63Hepatitis C_Homo sapiens_hsa051600.99034673
64Cocaine addiction_Homo sapiens_hsa050300.98465997
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97689087
66Sphingolipid metabolism_Homo sapiens_hsa006000.97361548
67Arginine biosynthesis_Homo sapiens_hsa002200.97048714
68Gastric acid secretion_Homo sapiens_hsa049710.95815194
69ErbB signaling pathway_Homo sapiens_hsa040120.95703235
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94493911
71Ovarian steroidogenesis_Homo sapiens_hsa049130.94391037
72Long-term potentiation_Homo sapiens_hsa047200.94364331
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94340196
74Renal cell carcinoma_Homo sapiens_hsa052110.92513425
75Starch and sucrose metabolism_Homo sapiens_hsa005000.92503154
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88717355
77Thyroid hormone synthesis_Homo sapiens_hsa049180.87899441
78N-Glycan biosynthesis_Homo sapiens_hsa005100.87288362
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.87211933
80Salivary secretion_Homo sapiens_hsa049700.86924749
81Morphine addiction_Homo sapiens_hsa050320.86887746
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86844457
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86082083
84Selenocompound metabolism_Homo sapiens_hsa004500.86032058
85Carbon metabolism_Homo sapiens_hsa012000.85031668
86Long-term depression_Homo sapiens_hsa047300.84076629
87Taste transduction_Homo sapiens_hsa047420.84055187
88Estrogen signaling pathway_Homo sapiens_hsa049150.83409974
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83112420
90Circadian rhythm_Homo sapiens_hsa047100.83003624
91Insulin signaling pathway_Homo sapiens_hsa049100.82530254
92Ether lipid metabolism_Homo sapiens_hsa005650.82455447
93T cell receptor signaling pathway_Homo sapiens_hsa046600.82298513
94Regulation of autophagy_Homo sapiens_hsa041400.81604536
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80932495
96Notch signaling pathway_Homo sapiens_hsa043300.80583537
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.80078769
98Lysosome_Homo sapiens_hsa041420.79781511
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78664120
100AMPK signaling pathway_Homo sapiens_hsa041520.78314736
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77998068
102TNF signaling pathway_Homo sapiens_hsa046680.77657335
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77183057
104Toxoplasmosis_Homo sapiens_hsa051450.76038964
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.75614589
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.75503627
107PPAR signaling pathway_Homo sapiens_hsa033200.75327028
108Renin secretion_Homo sapiens_hsa049240.74277588
109Measles_Homo sapiens_hsa051620.73602367
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71954187
111Chronic myeloid leukemia_Homo sapiens_hsa052200.71562969
112ABC transporters_Homo sapiens_hsa020100.70418746
113Phagosome_Homo sapiens_hsa041450.69758573
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.69734032
115Influenza A_Homo sapiens_hsa051640.69440688
116Pancreatic cancer_Homo sapiens_hsa052120.69238594
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68072607
118Legionellosis_Homo sapiens_hsa051340.67494396
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67070290
120mTOR signaling pathway_Homo sapiens_hsa041500.66865245
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.65744134
122Phenylalanine metabolism_Homo sapiens_hsa003600.65115044
123Fatty acid biosynthesis_Homo sapiens_hsa000610.64959209
124Linoleic acid metabolism_Homo sapiens_hsa005910.63673048
125HIF-1 signaling pathway_Homo sapiens_hsa040660.63228687
126African trypanosomiasis_Homo sapiens_hsa051430.61918930
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.61783395
128Glioma_Homo sapiens_hsa052140.60495457
129Glutamatergic synapse_Homo sapiens_hsa047240.59522732
130cAMP signaling pathway_Homo sapiens_hsa040240.59416508
131Malaria_Homo sapiens_hsa051440.59040701
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57748144
133beta-Alanine metabolism_Homo sapiens_hsa004100.57537988
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57119763
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56847974
136Hepatitis B_Homo sapiens_hsa051610.56205743
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56049292
138Mineral absorption_Homo sapiens_hsa049780.56037491
139Fructose and mannose metabolism_Homo sapiens_hsa000510.55606002
140Nicotine addiction_Homo sapiens_hsa050330.54918872
141Galactose metabolism_Homo sapiens_hsa000520.53722951
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53699852
143Rap1 signaling pathway_Homo sapiens_hsa040150.52926121
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52811344
145Protein digestion and absorption_Homo sapiens_hsa049740.51859195
146Dilated cardiomyopathy_Homo sapiens_hsa054140.51424430
147Vascular smooth muscle contraction_Homo sapiens_hsa042700.50953059
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49635059
149Histidine metabolism_Homo sapiens_hsa003400.49482709
150GnRH signaling pathway_Homo sapiens_hsa049120.48624372
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48546122
152Prolactin signaling pathway_Homo sapiens_hsa049170.48018795
153Serotonergic synapse_Homo sapiens_hsa047260.47804109
154Oxytocin signaling pathway_Homo sapiens_hsa049210.47341910
155Gap junction_Homo sapiens_hsa045400.46974795
156Peroxisome_Homo sapiens_hsa041460.46658322
157Biosynthesis of amino acids_Homo sapiens_hsa012300.46086331
158Endocytosis_Homo sapiens_hsa041440.44155063
159Prion diseases_Homo sapiens_hsa050200.41069808
160Caffeine metabolism_Homo sapiens_hsa002320.39091549
161Endometrial cancer_Homo sapiens_hsa052130.38711501

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