ORMDL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.47526514
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.00756182
3L-phenylalanine catabolic process (GO:0006559)5.00756182
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.99438221
5L-phenylalanine metabolic process (GO:0006558)4.99438221
6valine metabolic process (GO:0006573)4.94264466
7regulation of sequestering of triglyceride (GO:0010889)4.83798754
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.81866699
9positive regulation of fatty acid beta-oxidation (GO:0032000)4.73449315
10regulation of triglyceride catabolic process (GO:0010896)4.65419483
11sulfur amino acid catabolic process (GO:0000098)4.63739924
12fatty acid beta-oxidation (GO:0006635)4.41823633
13positive regulation of fatty acid oxidation (GO:0046321)4.38959577
14biotin metabolic process (GO:0006768)4.37610519
15very-low-density lipoprotein particle assembly (GO:0034379)4.30305060
16regulation of fatty acid beta-oxidation (GO:0031998)4.23568941
17triglyceride catabolic process (GO:0019433)4.21211182
18low-density lipoprotein particle clearance (GO:0034383)4.19385645
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.18545809
20fatty acid oxidation (GO:0019395)4.18307868
21lysine catabolic process (GO:0006554)4.17331911
22lysine metabolic process (GO:0006553)4.17331911
23plasma lipoprotein particle assembly (GO:0034377)4.14398430
24neutral lipid catabolic process (GO:0046461)4.13953167
25acylglycerol catabolic process (GO:0046464)4.13953167
26fatty acid transmembrane transport (GO:1902001)4.13879557
27lipid oxidation (GO:0034440)4.10206666
28aromatic amino acid family catabolic process (GO:0009074)4.09482254
29fatty acid catabolic process (GO:0009062)4.06674077
30complement activation, alternative pathway (GO:0006957)4.06319096
31cysteine metabolic process (GO:0006534)4.05451768
32acylglycerol homeostasis (GO:0055090)4.04734367
33triglyceride homeostasis (GO:0070328)4.04734367
34regulation of fatty acid oxidation (GO:0046320)3.98230077
35positive regulation of lipid catabolic process (GO:0050996)3.98194810
36regulation of cholesterol esterification (GO:0010872)3.94551728
37protein-lipid complex assembly (GO:0065005)3.91605619
38regulation of plasminogen activation (GO:0010755)3.91154958
392-oxoglutarate metabolic process (GO:0006103)3.87085722
40plasma lipoprotein particle clearance (GO:0034381)3.86343915
41acetyl-CoA metabolic process (GO:0006084)3.84493040
42carnitine shuttle (GO:0006853)3.84266715
43bile acid biosynthetic process (GO:0006699)3.82559583
44high-density lipoprotein particle remodeling (GO:0034375)3.82309353
45short-chain fatty acid metabolic process (GO:0046459)3.82195874
46amino-acid betaine metabolic process (GO:0006577)3.81633267
47branched-chain amino acid catabolic process (GO:0009083)3.80341752
48peptidyl-glutamic acid carboxylation (GO:0017187)3.73969166
49protein carboxylation (GO:0018214)3.73969166
50monocarboxylic acid catabolic process (GO:0072329)3.73150548
51blood coagulation, intrinsic pathway (GO:0007597)3.72587450
52positive regulation of triglyceride metabolic process (GO:0090208)3.72272916
53urea metabolic process (GO:0019627)3.70808934
54urea cycle (GO:0000050)3.70808934
55regulation of apoptotic cell clearance (GO:2000425)3.69688679
56branched-chain amino acid metabolic process (GO:0009081)3.69428279
57reverse cholesterol transport (GO:0043691)3.69388634
58negative regulation of fibrinolysis (GO:0051918)3.69200081
59positive regulation of lipoprotein lipase activity (GO:0051006)3.68497378
60positive regulation of triglyceride lipase activity (GO:0061365)3.68497378
61ethanol oxidation (GO:0006069)3.66977380
62regulation of protein activation cascade (GO:2000257)3.63520540
63ethanol metabolic process (GO:0006067)3.60953545
64glyoxylate metabolic process (GO:0046487)3.59190141
65regulation of extracellular matrix disassembly (GO:0010715)3.58447929
66serine family amino acid catabolic process (GO:0009071)3.58007956
67positive regulation of extracellular matrix organization (GO:1903055)3.56219029
68kynurenine metabolic process (GO:0070189)3.55860260
69fibrinolysis (GO:0042730)3.55751581
70positive regulation of fatty acid metabolic process (GO:0045923)3.54539559
71diacylglycerol metabolic process (GO:0046339)3.54383479
72regulation of cholesterol homeostasis (GO:2000188)3.51361986
73homocysteine metabolic process (GO:0050667)3.47703193
74regulation of complement activation (GO:0030449)3.47501994
75intestinal cholesterol absorption (GO:0030299)3.46315812
76regulation of triglyceride metabolic process (GO:0090207)3.46091357
77negative regulation of lipase activity (GO:0060192)3.41250745
78complement activation, classical pathway (GO:0006958)3.41149885
79nitrogen cycle metabolic process (GO:0071941)3.40515647
80acyl-CoA biosynthetic process (GO:0071616)3.39679234
81thioester biosynthetic process (GO:0035384)3.39679234
82proline metabolic process (GO:0006560)3.39563094
83acute-phase response (GO:0006953)3.39213381
84bile acid metabolic process (GO:0008206)3.39209999
85protein activation cascade (GO:0072376)3.37837925
86tryptophan catabolic process (GO:0006569)3.36751069
87indole-containing compound catabolic process (GO:0042436)3.36751069
88indolalkylamine catabolic process (GO:0046218)3.36751069
89regulation of fibrinolysis (GO:0051917)3.35273430
90regulation of extracellular matrix organization (GO:1903053)3.34867848
91plasma lipoprotein particle remodeling (GO:0034369)3.33586680
92protein-lipid complex remodeling (GO:0034368)3.33586680
93macromolecular complex remodeling (GO:0034367)3.33586680
94cholesterol efflux (GO:0033344)3.33473149
95tricarboxylic acid metabolic process (GO:0072350)3.33185256
96plasma lipoprotein particle organization (GO:0071827)3.31704997
97alpha-amino acid catabolic process (GO:1901606)3.31591181
98low-density lipoprotein particle remodeling (GO:0034374)3.31222808
99carnitine metabolic process (GO:0009437)3.29942300
100carboxylic acid catabolic process (GO:0046395)3.28736786
101organic acid catabolic process (GO:0016054)3.28736786
102regulation of triglyceride biosynthetic process (GO:0010866)3.27670535
103cellular amino acid catabolic process (GO:0009063)3.27342598
104positive regulation of hemostasis (GO:1900048)3.25668063
105positive regulation of blood coagulation (GO:0030194)3.25668063
106protein-lipid complex subunit organization (GO:0071825)3.24284278
107regulation of lipid catabolic process (GO:0050994)3.23806654
108triglyceride metabolic process (GO:0006641)3.23572256
109fatty-acyl-CoA biosynthetic process (GO:0046949)3.20572516
110oxaloacetate metabolic process (GO:0006107)3.19095737
111complement activation (GO:0006956)3.18301813
112NADH metabolic process (GO:0006734)3.17652544
113tryptophan metabolic process (GO:0006568)3.17537509
114epoxygenase P450 pathway (GO:0019373)3.17448933
115cellular ketone body metabolic process (GO:0046950)3.16753908
116regulation of cholesterol storage (GO:0010885)3.16732066
117cellular modified amino acid catabolic process (GO:0042219)3.16504020
118negative regulation of sterol transport (GO:0032372)3.15409852
119negative regulation of cholesterol transport (GO:0032375)3.15409852
120positive regulation of triglyceride biosynthetic process (GO:0010867)3.15108799
121phospholipid efflux (GO:0033700)3.13572868
122fatty acid homeostasis (GO:0055089)3.12129288
123regulation of cholesterol biosynthetic process (GO:0045540)3.11356906
124acylglycerol metabolic process (GO:0006639)3.10512408
125regulation of humoral immune response (GO:0002920)3.09858821
126negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.09342658
127carnitine transmembrane transport (GO:1902603)3.09294563
128regulation of bile acid biosynthetic process (GO:0070857)3.08418231
129tyrosine metabolic process (GO:0006570)3.07914710
130negative regulation of blood coagulation (GO:0030195)3.07768744
131negative regulation of hemostasis (GO:1900047)3.07768744
132coenzyme catabolic process (GO:0009109)3.07690682
133neutral lipid metabolic process (GO:0006638)3.06013290
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.02584029
135positive regulation of coagulation (GO:0050820)3.01149306
136negative regulation of protein activation cascade (GO:2000258)2.98834682
137regulation of cholesterol metabolic process (GO:0090181)2.91829323
138progesterone metabolic process (GO:0042448)2.90532767
139intestinal absorption (GO:0050892)2.87927396
140negative regulation of fatty acid biosynthetic process (GO:0045717)2.84432020
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79497813
142negative regulation of fatty acid transport (GO:2000192)2.78695267
143proline biosynthetic process (GO:0006561)2.78486613
144negative regulation of lipid transport (GO:0032369)2.76577957
145exogenous drug catabolic process (GO:0042738)2.74989135
146negative regulation of coagulation (GO:0050819)2.72841305
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67444204
148negative regulation of wound healing (GO:0061045)2.67167049
149lipoprotein metabolic process (GO:0042157)2.67089166
150basement membrane organization (GO:0071711)2.66597818
151COPI coating of Golgi vesicle (GO:0048205)2.65044110
152Golgi transport vesicle coating (GO:0048200)2.65044110
153glutamate metabolic process (GO:0006536)2.64109768
154regulation of glucose import in response to insulin stimulus (GO:2001273)2.61807257
155response to mercury ion (GO:0046689)2.59528120
156cellular glucuronidation (GO:0052695)2.54786827
157positive regulation of steroid metabolic process (GO:0045940)2.54691951
158acute inflammatory response (GO:0002526)2.54292834
159cholesterol homeostasis (GO:0042632)2.50249454
160negative regulation of complement activation (GO:0045916)2.50246983
161positive regulation of fatty acid biosynthetic process (GO:0045723)2.49872537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.07076054
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.00372720
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.05357929
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.28831072
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.72495060
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88660927
7* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.88097890
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.37833141
9CLOCK_20551151_ChIP-Seq_293T_Human3.28990616
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.16250975
11* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.08233945
12ZNF263_19887448_ChIP-Seq_K562_Human2.37990390
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.14512964
14MYC_22102868_ChIP-Seq_BL_Human2.08837129
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06565501
16* TCF7_22412390_ChIP-Seq_EML_Mouse1.95554178
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88876304
18GATA1_22025678_ChIP-Seq_K562_Human1.87073063
19VDR_21846776_ChIP-Seq_THP-1_Human1.80502641
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.72418547
21* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58812315
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52542292
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51362890
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48101721
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.46310758
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43883968
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43874842
28* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41747248
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41434105
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37489878
31LXR_22292898_ChIP-Seq_THP-1_Human1.36215658
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.31452479
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.30783131
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29708211
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28487784
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.28220906
37MAF_26560356_Chip-Seq_TH1_Human1.27160688
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25578138
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.24505290
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22490693
41* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21836646
42GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21545418
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20822919
44VDR_24763502_ChIP-Seq_THP-1_Human1.20162818
45* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19844934
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19231541
47* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17779738
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17719369
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.17193933
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16026834
51* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15750727
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.14997692
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13610005
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13607044
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10491744
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.10371184
57* UTX_26944678_Chip-Seq_JUKART_Human1.09063221
58* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07875305
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07852239
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07338711
61* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06647748
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03650462
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02449773
64MAF_26560356_Chip-Seq_TH2_Human1.01605234
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.00068279
66NCOR1_26117541_ChIP-Seq_K562_Human1.00061763
67CDX2_20551321_ChIP-Seq_CACO-2_Human0.99987933
68GATA1_19941826_ChIP-Seq_K562_Human0.99392585
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98772486
70RACK7_27058665_Chip-Seq_MCF-7_Human0.98290781
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98229384
72* HNF4A_19822575_ChIP-Seq_HepG2_Human0.97710474
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97597330
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95958462
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95749610
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.94602604
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94560534
78GATA6_25053715_ChIP-Seq_YYC3_Human0.94500536
79ESR1_20079471_ChIP-ChIP_T-47D_Human0.94171231
80TBX20_22328084_ChIP-Seq_HEART_Mouse0.94079031
81TBX20_22080862_ChIP-Seq_HEART_Mouse0.94079031
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93573893
83* ERG_21242973_ChIP-ChIP_JURKAT_Human0.93368600
84CREB1_26743006_Chip-Seq_LNCaP_Human0.92916780
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92364081
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89577794
87GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89024995
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88649291
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88624317
90KDM2B_26808549_Chip-Seq_K562_Human0.88062340
91HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87920568
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87055469
93PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86984152
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.86525510
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85903471
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84244629
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84010576
98* ATF3_27146783_Chip-Seq_COLON_Human0.83998863
99FOXO3_23340844_ChIP-Seq_DLD1_Human0.83600308
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82417866
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.81358413
102* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79984817
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79879598
104NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79131630
105* P68_20966046_ChIP-Seq_HELA_Human0.77556357
106GATA4_25053715_ChIP-Seq_YYC3_Human0.76945796
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76918099
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74658487
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74422003
110* GATA1_19941827_ChIP-Seq_MEL_Mouse0.74086066
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73703142
112* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.72564499
113* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72441327
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72126229
115* SMC4_20622854_ChIP-Seq_HELA_Human0.72090710
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71935140
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71832417
118GATA2_19941826_ChIP-Seq_K562_Human0.71749038
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.71243254
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.71110170
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70909815
122RUNX1_27514584_Chip-Seq_MCF-7_Human0.70890028
123* TP63_22573176_ChIP-Seq_HFKS_Human0.70241563
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70230099
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.68447354
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68118664
127* RARB_24833708_ChIP-Seq_LIVER_Mouse0.68108801
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.68083542
129* BCOR_27268052_Chip-Seq_Bcells_Human0.68063145
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.67496774
131ELF1_20517297_ChIP-Seq_JURKAT_Human0.67043436
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.65267086
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.63657185
134CTCF_27219007_Chip-Seq_Bcells_Human0.63267280
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.62277889
136* RARA_24833708_ChIP-Seq_LIVER_Mouse0.62250733
137KDM2B_26808549_Chip-Seq_DND41_Human0.61088677
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61046336
139KLF4_19829295_ChIP-Seq_ESCs_Human0.60809197
140CTCF_21964334_Chip-Seq_Bcells_Human0.59855020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.87924118
2MP0005365_abnormal_bile_salt4.98081436
3MP0005360_urolithiasis4.83302185
4MP0005670_abnormal_white_adipose4.07211021
5MP0005085_abnormal_gallbladder_physiolo4.06617967
6MP0010329_abnormal_lipoprotein_level3.66021153
7MP0008875_abnormal_xenobiotic_pharmacok3.25288109
8MP0004130_abnormal_muscle_cell3.04425713
9MP0003252_abnormal_bile_duct2.84738532
10MP0005666_abnormal_adipose_tissue2.79864310
11MP0005451_abnormal_body_composition2.67445345
12MP0009840_abnormal_foam_cell2.45713174
13MP0003806_abnormal_nucleotide_metabolis2.45470528
14MP0002118_abnormal_lipid_homeostasis2.40946890
15MP0003191_abnormal_cellular_cholesterol2.32249306
16MP0003705_abnormal_hypodermis_morpholog2.30421648
17MP0001666_abnormal_nutrient_absorption2.28946448
18MP0005332_abnormal_amino_acid2.27304336
19MP0004185_abnormal_adipocyte_glucose2.16410531
20MP0005375_adipose_tissue_phenotype2.12359460
21MP0000609_abnormal_liver_physiology2.09690261
22MP0002971_abnormal_brown_adipose2.08951518
23MP0003195_calcinosis2.01944300
24MP0008438_abnormal_cutaneous_collagen2.01215242
25MP0005083_abnormal_biliary_tract1.98711385
26MP0000013_abnormal_adipose_tissue1.92914345
27MP0002837_dystrophic_cardiac_calcinosis1.91181213
28MP0003566_abnormal_cell_adhesion1.88505690
29MP0003436_decreased_susceptibility_to1.76859829
30MP0001984_abnormal_olfaction1.74493434
31MP0002138_abnormal_hepatobiliary_system1.71365504
32MP0000858_altered_metastatic_potential1.70879138
33MP0005319_abnormal_enzyme/_coenzyme1.69825224
34MP0003011_delayed_dark_adaptation1.67757423
35MP0000003_abnormal_adipose_tissue1.67685770
36MP0002132_abnormal_respiratory_system1.65690758
37MP0002909_abnormal_adrenal_gland1.57090628
38MP0005584_abnormal_enzyme/coenzyme_acti1.55908331
39MP0005334_abnormal_fat_pad1.54887259
40MP0005275_abnormal_skin_tensile1.53945910
41MP0005409_darkened_coat_color1.53402372
42MP0008260_abnormal_autophagy1.52195078
43MP0005464_abnormal_platelet_physiology1.50309517
44MP0001661_extended_life_span1.48062658
45MP0002078_abnormal_glucose_homeostasis1.47242254
46MP0005535_abnormal_body_temperature1.47234424
47MP0003172_abnormal_lysosome_physiology1.47033256
48MP0004019_abnormal_vitamin_homeostasis1.47007456
49MP0004264_abnormal_extraembryonic_tissu1.45990635
50MP0005257_abnormal_intraocular_pressure1.41951305
51MP0002089_abnormal_postnatal_growth/wei1.36300700
52MP0003868_abnormal_feces_composition1.35550134
53MP0003303_peritoneal_inflammation1.35203623
54MP0006036_abnormal_mitochondrial_physio1.33180094
55MP0009643_abnormal_urine_homeostasis1.33042394
56MP0005076_abnormal_cell_differentiation1.31909287
57MP0002166_altered_tumor_susceptibility1.30760703
58MP0000685_abnormal_immune_system1.30599414
59MP0001764_abnormal_homeostasis1.30074978
60MP0003091_abnormal_cell_migration1.26616829
61MP0005448_abnormal_energy_balance1.25654361
62MP0003183_abnormal_peptide_metabolism1.25438691
63MP0009115_abnormal_fat_cell1.25295724
64MP0002970_abnormal_white_adipose1.23867465
65MP0008961_abnormal_basal_metabolism1.23500136
66MP0001849_ear_inflammation1.21781193
67MP0010234_abnormal_vibrissa_follicle1.15333591
68MP0003959_abnormal_lean_body1.13784102
69MP0001348_abnormal_lacrimal_gland1.13653052
70MP0003656_abnormal_erythrocyte_physiolo1.12730992
71MP0003453_abnormal_keratinocyte_physiol1.12396258
72MP0005023_abnormal_wound_healing1.11311645
73MP0004858_abnormal_nervous_system1.11205687
74MP0002933_joint_inflammation1.11100727
75MP0001915_intracranial_hemorrhage1.10708856
76MP0004947_skin_inflammation1.09378024
77MP0009333_abnormal_splenocyte_physiolog1.08803387
78MP0003724_increased_susceptibility_to1.08378513
79MP0002876_abnormal_thyroid_physiology1.07235322
80MP0005220_abnormal_exocrine_pancreas1.06690348
81MP0003186_abnormal_redox_activity1.06106356
82MP0001958_emphysema1.05875868
83MP0002090_abnormal_vision1.01210307
84MP0005647_abnormal_sex_gland1.00172036
85MP0010155_abnormal_intestine_physiology1.00000901
86MP0000678_abnormal_parathyroid_gland0.95886162
87MP0003763_abnormal_thymus_physiology0.95096644
88MP0009780_abnormal_chondrocyte_physiolo0.94867916
89MP0001756_abnormal_urination0.94493620
90MP0001533_abnormal_skeleton_physiology0.93652394
91MP0000598_abnormal_liver_morphology0.93312415
92MP0000566_synostosis0.89705243
93MP0001851_eye_inflammation0.88916786
94MP0003329_amyloid_beta_deposits0.88202704
95MP0000604_amyloidosis0.87616978
96MP0005025_abnormal_response_to0.87499442
97MP0004043_abnormal_pH_regulation0.87174167
98MP0001881_abnormal_mammary_gland0.86532875
99MP0003953_abnormal_hormone_level0.85287785
100MP0000249_abnormal_blood_vessel0.84726654
101MP0001944_abnormal_pancreas_morphology0.84382978
102MP0010368_abnormal_lymphatic_system0.82458854
103MP0005387_immune_system_phenotype0.81302028
104MP0001790_abnormal_immune_system0.81302028
105MP0005408_hypopigmentation0.81292728
106MP0009642_abnormal_blood_homeostasis0.78536427
107MP0008469_abnormal_protein_level0.77034378
108MP0000767_abnormal_smooth_muscle0.76640937
109MP0004782_abnormal_surfactant_physiolog0.76233051
110MP0005636_abnormal_mineral_homeostasis0.76187744
111MP0005330_cardiomyopathy0.74011156
112MP0002254_reproductive_system_inflammat0.73288132
113MP0002998_abnormal_bone_remodeling0.72951166
114MP0002060_abnormal_skin_morphology0.72892173
115MP0000230_abnormal_systemic_arterial0.72800222
116MP0005164_abnormal_response_to0.72798408
117MP0003879_abnormal_hair_cell0.71447598
118MP0005452_abnormal_adipose_tissue0.71289543
119MP0002796_impaired_skin_barrier0.70874047
120MP0003300_gastrointestinal_ulcer0.70566556
121MP0002249_abnormal_larynx_morphology0.70147519
122MP0001800_abnormal_humoral_immune0.68829326
123MP0002419_abnormal_innate_immunity0.68577523
124MP0005058_abnormal_lysosome_morphology0.66759160
125MP0008775_abnormal_heart_ventricle0.66460269
126MP0009763_increased_sensitivity_to0.66428166
127MP0003690_abnormal_glial_cell0.65362169
128MP0005551_abnormal_eye_electrophysiolog0.65289430
129MP0006138_congestive_heart_failure0.64658258
130MP0009384_cardiac_valve_regurgitation0.63173258
131MP0005084_abnormal_gallbladder_morpholo0.62650281
132MP0004147_increased_porphyrin_level0.61298738
133MP0002269_muscular_atrophy0.60629731
134MP0004272_abnormal_basement_membrane0.60262744
135MP0004087_abnormal_muscle_fiber0.58516042
136MP0006035_abnormal_mitochondrial_morpho0.58371942
137MP0005248_abnormal_Harderian_gland0.57183806
138MP0004036_abnormal_muscle_relaxation0.56195573
139MP0003221_abnormal_cardiomyocyte_apopto0.54798349
140MP0005376_homeostasis/metabolism_phenot0.54335997
141MP0004084_abnormal_cardiac_muscle0.52876079
142MP0009765_abnormal_xenobiotic_induced0.51556025
143MP0002877_abnormal_melanocyte_morpholog0.50036445
144MP0009764_decreased_sensitivity_to0.49899012
145MP0005620_abnormal_muscle_contractility0.49662890
146MP0000751_myopathy0.49228108
147MP0002168_other_aberrant_phenotype0.48874433
148MP0005595_abnormal_vascular_smooth0.48819485
149MP0005266_abnormal_metabolism0.48096975
150MP0000639_abnormal_adrenal_gland0.47900093

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.07419233
2Hyperglycinuria (HP:0003108)5.03722702
3Deep venous thrombosis (HP:0002625)4.95081832
4Xanthomatosis (HP:0000991)4.93133886
5Hypoglycemic coma (HP:0001325)4.69147877
6Ketosis (HP:0001946)4.46381503
7Abnormality of serine family amino acid metabolism (HP:0010894)4.44693022
8Abnormality of glycine metabolism (HP:0010895)4.44693022
9Hyperlipoproteinemia (HP:0010980)4.40416579
10Hyperglycinemia (HP:0002154)4.34716122
11Complement deficiency (HP:0004431)4.21553425
12Intrahepatic cholestasis (HP:0001406)4.19601887
13Hyperammonemia (HP:0001987)4.08851802
14Ketoacidosis (HP:0001993)4.00760501
15Abnormality of fatty-acid metabolism (HP:0004359)3.99939236
16Systemic lupus erythematosus (HP:0002725)3.90487476
17Hypoalphalipoproteinemia (HP:0003233)3.87628980
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.83468095
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.79020896
20Epidermoid cyst (HP:0200040)3.70079295
21Hypobetalipoproteinemia (HP:0003563)3.66418194
22Hypolipoproteinemia (HP:0010981)3.57443792
23Prolonged partial thromboplastin time (HP:0003645)3.53228811
24Glomerulonephritis (HP:0000099)3.46256067
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39034122
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23684826
27Myoglobinuria (HP:0002913)3.23130521
28Oligomenorrhea (HP:0000876)3.20006309
29Abnormality of the common coagulation pathway (HP:0010990)3.11169230
30Menorrhagia (HP:0000132)3.04249731
31Abnormality of the intrinsic pathway (HP:0010989)3.04230577
32Dicarboxylic aciduria (HP:0003215)3.01591883
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.01591883
34Abnormality of complement system (HP:0005339)2.90565281
35Abnormality of proline metabolism (HP:0010907)2.84565690
36Hydroxyprolinuria (HP:0003080)2.84565690
37Flat acetabular roof (HP:0003180)2.83287166
38Purpura (HP:0000979)2.82349105
39Hypercholesterolemia (HP:0003124)2.82239712
40Hypertriglyceridemia (HP:0002155)2.80688608
41Skin nodule (HP:0200036)2.79785731
42Nephritis (HP:0000123)2.70220000
43Hypoglycemic seizures (HP:0002173)2.69277438
44Gingival bleeding (HP:0000225)2.64895729
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.59560628
46Recurrent gram-negative bacterial infections (HP:0005420)2.58735885
47Acanthosis nigricans (HP:0000956)2.58081500
48Abnormality of serum amino acid levels (HP:0003112)2.55513592
49Fat malabsorption (HP:0002630)2.53377187
50Generalized aminoaciduria (HP:0002909)2.51986917
51Abnormality of purine metabolism (HP:0004352)2.48636606
52Hyperbilirubinemia (HP:0002904)2.45572426
53Eczematoid dermatitis (HP:0000976)2.44096365
54Metabolic acidosis (HP:0001942)2.43511426
55Late onset (HP:0003584)2.41633280
56Myocardial infarction (HP:0001658)2.38931643
57Hyperglycemia (HP:0003074)2.37323241
58Abnormality of carpal bone ossification (HP:0006257)2.35095998
59Mitral stenosis (HP:0001718)2.33789280
60Brushfield spots (HP:0001088)2.33614461
61Hyperinsulinemic hypoglycemia (HP:0000825)2.33272401
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32645148
63Abnormal tarsal ossification (HP:0008369)2.29853871
64Rhabdomyolysis (HP:0003201)2.29029102
65Pigmentary retinal degeneration (HP:0001146)2.27157382
66Insulin-resistant diabetes mellitus (HP:0000831)2.25205086
67Vertebral compression fractures (HP:0002953)2.25189527
68Joint hemorrhage (HP:0005261)2.24590019
69Pancreatitis (HP:0001733)2.22757710
70Cholelithiasis (HP:0001081)2.22119881
71Insulin resistance (HP:0000855)2.21423277
72Abnormal cartilage morphology (HP:0002763)2.21228433
73Lethargy (HP:0001254)2.19418084
74Abnormal gallbladder morphology (HP:0012437)2.18948498
75Cerebral aneurysm (HP:0004944)2.15652000
76Gout (HP:0001997)2.14960866
77Vascular calcification (HP:0004934)2.14268531
78Hepatocellular carcinoma (HP:0001402)2.11945558
79Cholecystitis (HP:0001082)2.10969019
80Abnormal gallbladder physiology (HP:0012438)2.10969019
81Conjugated hyperbilirubinemia (HP:0002908)2.07939887
82Abnormal ossification of hand bones (HP:0005921)2.07374013
83Gastrointestinal infarctions (HP:0005244)2.05279047
84Arterial tortuosity (HP:0005116)2.03385853
85Cardiovascular calcification (HP:0011915)2.03323605
86Sensorimotor neuropathy (HP:0007141)2.03262058
87Abnormal platelet volume (HP:0011876)2.03133736
88Hemorrhage of the eye (HP:0011885)2.02442839
89Delayed CNS myelination (HP:0002188)2.02146373
90Prolonged bleeding time (HP:0003010)1.99578955
91Epistaxis (HP:0000421)1.99012091
92Abnormality of nucleobase metabolism (HP:0010932)1.98666615
93Back pain (HP:0003418)1.98465745
94Rickets (HP:0002748)1.97575132
95Polygenic inheritance (HP:0010982)1.96638449
96Vascular tortuosity (HP:0004948)1.96261844
97Increased mean platelet volume (HP:0011877)1.95966560
98Cupped ribs (HP:0000887)1.95406818
99Palpitations (HP:0001962)1.95072789
100Vomiting (HP:0002013)1.93805285
101Neonatal onset (HP:0003623)1.93199956
102Aneurysm (HP:0002617)1.91211428
103Small epiphyses (HP:0010585)1.91110369
104Growth hormone excess (HP:0000845)1.90590620
105Asymmetry of the thorax (HP:0001555)1.89488214
106Irritability (HP:0000737)1.89386979
107Nausea (HP:0002018)1.89227138
108Peritonitis (HP:0002586)1.87662553
109Abnormality of methionine metabolism (HP:0010901)1.87636889
110Subcapsular cataract (HP:0000523)1.87025479
111Coxa vara (HP:0002812)1.86995664
112Poikilocytosis (HP:0004447)1.86062679
113Malnutrition (HP:0004395)1.85039764
114Limb hypertonia (HP:0002509)1.84815972
115Cerebral edema (HP:0002181)1.84527345
116Polycythemia (HP:0001901)1.84508997
117Increased muscle lipid content (HP:0009058)1.84408965
118Amyloidosis (HP:0011034)1.83801466
119Thin bony cortex (HP:0002753)1.83446279
120Premature rupture of membranes (HP:0001788)1.83103352
121Emphysema (HP:0002097)1.81363177
122Protrusio acetabuli (HP:0003179)1.81254614
123Acanthocytosis (HP:0001927)1.80615553
124Turricephaly (HP:0000262)1.79986631
125Right ventricular cardiomyopathy (HP:0011663)1.78856388
126Central scotoma (HP:0000603)1.77939953
127Achilles tendon contracture (HP:0001771)1.77722640
128Colitis (HP:0002583)1.77680206
129Steatorrhea (HP:0002570)1.77446871
130Tetraparesis (HP:0002273)1.77315317
131Abnormality of the gallbladder (HP:0005264)1.75905484
132Exercise-induced myalgia (HP:0003738)1.75145027
133Spastic diplegia (HP:0001264)1.73693391
134Spontaneous abortion (HP:0005268)1.72850890
135Long toe (HP:0010511)1.72648595
136Abnormal hand bone ossification (HP:0010660)1.71798429
137Abnormality of the Achilles tendon (HP:0005109)1.71644046
138Stroke (HP:0001297)1.71166182
139Cellulitis (HP:0100658)1.71055302
140Gastrointestinal stroma tumor (HP:0100723)1.70940506
141Abnormal foot bone ossification (HP:0010675)1.70611912
142Gingivitis (HP:0000230)1.70217956
143Hypophosphatemia (HP:0002148)1.68140908
144Thrombophlebitis (HP:0004418)1.67312643
145Blue sclerae (HP:0000592)1.66644649
146Metaphyseal cupping (HP:0003021)1.66214712
147Pulmonary embolism (HP:0002204)1.65320436
148Elevated alkaline phosphatase (HP:0003155)1.64955647
149Biconcave vertebral bodies (HP:0004586)1.64099938
150Hypochromic anemia (HP:0001931)1.63914398
151Dilatation of the ascending aorta (HP:0005111)1.60568832
152Urinary glycosaminoglycan excretion (HP:0003541)1.60537515
153Mucopolysacchariduria (HP:0008155)1.60537515
154Osteomalacia (HP:0002749)1.60424710
155Aortic aneurysm (HP:0004942)1.59927710
156Cerebral inclusion bodies (HP:0100314)1.58324286
157Abnormal enzyme/coenzyme activity (HP:0012379)1.55719826
158Abnormality of the peritoneum (HP:0002585)1.55228241
159Abnormality of the acetabulum (HP:0003170)1.55123005
160Increased IgE level (HP:0003212)1.54854883
161Abnormality of alkaline phosphatase activity (HP:0004379)1.54600616
162Osteoarthritis (HP:0002758)1.54531620
163Increased variability in muscle fiber diameter (HP:0003557)1.54031750
164Bronchomalacia (HP:0002780)1.53570895
165Abnormality of the lumbar spine (HP:0100712)1.52617280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.41682018
2TRIB35.34157771
3ERN14.08373245
4SIK14.02377937
5PRPF4B3.18166470
6CAMK1D2.80973207
7CDK122.73893144
8PKN22.73687879
9SMG12.34474418
10RIPK12.33485826
11INSRR2.14316951
12FGFR42.06677553
13PDK32.05991321
14PDK42.05991321
15CAMK1G1.99703988
16LATS11.84147896
17RIPK41.57907676
18MAP3K131.55624722
19TAOK31.50981924
20LMTK21.50941714
21PDGFRA1.50269235
22ICK1.47116181
23MAP4K11.46861801
24EPHA21.46374272
25PTK61.44666643
26FRK1.43079070
27EEF2K1.42231221
28MATK1.36383011
29PHKG21.28276276
30PHKG11.28276276
31PINK11.24091404
32FLT31.22863092
33TESK11.17455624
34DAPK21.16954043
35MST1R1.16281390
36PRKAA21.14594197
37CDC42BPA1.12181675
38MAPKAPK31.11442567
39PIK3CG1.10408159
40PRKD31.10214086
41ZAP701.08510583
42PDK21.07449729
43EPHA31.07282132
44GRK61.00943410
45MAP3K70.97279170
46ARAF0.96945345
47PRKAA10.95977872
48MAP2K10.93846605
49DDR20.93816232
50DYRK1B0.92998486
51MAPK110.92760956
52RET0.91275888
53SIK20.89771870
54KSR20.86323570
55LATS20.84430348
56TAOK20.84073896
57PAK30.83291119
58MAP3K110.82479753
59MAP2K40.81960394
60FER0.81372851
61MAP3K100.80828810
62MTOR0.80434208
63JAK20.78631416
64MAP3K20.75291619
65EPHB20.74364081
66TGFBR20.73890991
67IRAK30.71445964
68CSK0.70967865
69JAK10.70332992
70PDPK10.66695388
71MAP3K60.65806518
72MAP3K140.65683394
73TTN0.64898072
74MAPK150.63878741
75PTK20.63482700
76TAOK10.63073626
77JAK30.63071943
78CDK90.62567282
79CDK60.61101495
80PRKD20.60525840
81CAMKK10.60177983
82BMX0.59620572
83MAP2K20.59478636
84PRKACG0.59227326
85CDK40.58727359
86CDK70.57879713
87HIPK20.57761119
88FGFR20.57120300
89TIE10.56934631
90NEK10.56262880
91STK380.55371122
92PRKCH0.55204657
93NTRK10.54742704
94MAP3K10.54202604
95SIK30.53696261
96PRKCZ0.52336661
97PRKD10.51966282
98STK38L0.51855108
99PRKG20.51831274
100IRAK10.51383602
101PAK20.51299762
102FGFR30.51219931
103MAP3K90.51110650
104IRAK40.50458896
105PAK60.47336366
106CSF1R0.46922228
107BTK0.45788945
108MAPK120.45292328
109MAP3K30.45036047
110PDK10.44801511
111MET0.44358929
112HCK0.44141474
113PAK40.43977705
114RPS6KL10.43828814
115RPS6KC10.43828814
116CAMKK20.43566875
117BLK0.43228943
118NEK90.41226990
119TNK20.40908724
120MAP3K80.40024366
121WNK10.39941736
122IKBKE0.38893376
123YES10.38889258
124LRRK20.38340978
125ERBB20.37769152
126IRAK20.37613591
127FGR0.37227833
128TYK20.37167455
129BRAF0.36479336
130MYLK0.36337626
131NLK0.35839323
132GSK3A0.35789372
133CAMK2G0.35744125
134TYRO30.35464714
135SGK30.35322987
136AKT30.34912659
137MAP2K30.34500585
138MARK20.32800178
139PDGFRB0.31557169
140EPHB10.31132276
141RPS6KA20.30942261
142ILK0.30564266
143DAPK30.29150044
144CSNK1G10.29018891
145TBK10.28758592

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.22293606
2Fatty acid degradation_Homo sapiens_hsa000713.18739790
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.10222556
4Propanoate metabolism_Homo sapiens_hsa006403.09368219
5Nitrogen metabolism_Homo sapiens_hsa009102.94883180
6PPAR signaling pathway_Homo sapiens_hsa033202.83711499
7Fatty acid metabolism_Homo sapiens_hsa012122.70629805
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62492673
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40004558
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37415762
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.31411447
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28884573
13Arginine biosynthesis_Homo sapiens_hsa002202.22124344
14Tryptophan metabolism_Homo sapiens_hsa003802.18902946
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17726709
16Fatty acid biosynthesis_Homo sapiens_hsa000612.04497627
17Butanoate metabolism_Homo sapiens_hsa006502.02041242
18Pyruvate metabolism_Homo sapiens_hsa006201.94684408
19Peroxisome_Homo sapiens_hsa041461.83672355
20Complement and coagulation cascades_Homo sapiens_hsa046101.83085843
21Caffeine metabolism_Homo sapiens_hsa002321.82923003
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79980035
23beta-Alanine metabolism_Homo sapiens_hsa004101.73007195
24Other glycan degradation_Homo sapiens_hsa005111.69611062
25Fat digestion and absorption_Homo sapiens_hsa049751.66721062
26Carbon metabolism_Homo sapiens_hsa012001.64706393
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49028560
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41497568
29Glycerolipid metabolism_Homo sapiens_hsa005611.40033803
30Bile secretion_Homo sapiens_hsa049761.37807335
31Fatty acid elongation_Homo sapiens_hsa000621.31271402
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30522210
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29354084
34Sulfur metabolism_Homo sapiens_hsa009201.27118376
35Non-small cell lung cancer_Homo sapiens_hsa052231.26853831
36Acute myeloid leukemia_Homo sapiens_hsa052211.23312194
37Biosynthesis of amino acids_Homo sapiens_hsa012301.21485161
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.20453347
39Starch and sucrose metabolism_Homo sapiens_hsa005001.19793183
40Chemical carcinogenesis_Homo sapiens_hsa052041.17946395
41Selenocompound metabolism_Homo sapiens_hsa004501.17880322
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16675083
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.15609745
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14442588
45ABC transporters_Homo sapiens_hsa020101.14358245
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12630159
47Phenylalanine metabolism_Homo sapiens_hsa003601.10670859
48Retinol metabolism_Homo sapiens_hsa008301.09447052
49Histidine metabolism_Homo sapiens_hsa003401.08607705
50Chronic myeloid leukemia_Homo sapiens_hsa052201.04089757
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.03964799
52Pancreatic cancer_Homo sapiens_hsa052121.03684931
53B cell receptor signaling pathway_Homo sapiens_hsa046621.00153532
54Tyrosine metabolism_Homo sapiens_hsa003500.99761824
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99110927
56Folate biosynthesis_Homo sapiens_hsa007900.99086424
57Endometrial cancer_Homo sapiens_hsa052130.96878728
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96166401
59Sulfur relay system_Homo sapiens_hsa041220.95864915
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.95060732
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91822977
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.86869497
63Staphylococcus aureus infection_Homo sapiens_hsa051500.86515343
64Insulin resistance_Homo sapiens_hsa049310.86198429
65AMPK signaling pathway_Homo sapiens_hsa041520.85491241
66Vitamin B6 metabolism_Homo sapiens_hsa007500.82752190
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.79957766
68Thyroid cancer_Homo sapiens_hsa052160.79072855
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78811988
70Lysine degradation_Homo sapiens_hsa003100.76798909
71VEGF signaling pathway_Homo sapiens_hsa043700.72615146
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72020510
73Notch signaling pathway_Homo sapiens_hsa043300.71594328
74Hepatitis C_Homo sapiens_hsa051600.69397138
75Renal cell carcinoma_Homo sapiens_hsa052110.68814899
76Glucagon signaling pathway_Homo sapiens_hsa049220.68301057
77Pentose phosphate pathway_Homo sapiens_hsa000300.66590402
78Vitamin digestion and absorption_Homo sapiens_hsa049770.65558326
79Bladder cancer_Homo sapiens_hsa052190.64018492
80Renin-angiotensin system_Homo sapiens_hsa046140.63777896
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.63417933
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62068205
83Insulin signaling pathway_Homo sapiens_hsa049100.61696206
84Focal adhesion_Homo sapiens_hsa045100.60267604
85Fructose and mannose metabolism_Homo sapiens_hsa000510.58476973
86Prostate cancer_Homo sapiens_hsa052150.57237303
87Prolactin signaling pathway_Homo sapiens_hsa049170.56831797
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56123168
89Arginine and proline metabolism_Homo sapiens_hsa003300.54262875
90Osteoclast differentiation_Homo sapiens_hsa043800.53074693
91Galactose metabolism_Homo sapiens_hsa000520.52897988
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.50904414
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50768058
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50244665
95Pertussis_Homo sapiens_hsa051330.50200271
96Toxoplasmosis_Homo sapiens_hsa051450.48846142
97Amoebiasis_Homo sapiens_hsa051460.48712081
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.48077760
99Adherens junction_Homo sapiens_hsa045200.47797744
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47557606
101ECM-receptor interaction_Homo sapiens_hsa045120.47091953
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47020383
103Choline metabolism in cancer_Homo sapiens_hsa052310.46591228
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46158894
105Leishmaniasis_Homo sapiens_hsa051400.45867990
106T cell receptor signaling pathway_Homo sapiens_hsa046600.44607804
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.44402783
108Influenza A_Homo sapiens_hsa051640.44009810
109Proteoglycans in cancer_Homo sapiens_hsa052050.43701780
110ErbB signaling pathway_Homo sapiens_hsa040120.42340529
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41765783
112Small cell lung cancer_Homo sapiens_hsa052220.41080542
113HIF-1 signaling pathway_Homo sapiens_hsa040660.40986071
114Protein digestion and absorption_Homo sapiens_hsa049740.39894471
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.39194896
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36921170
117Metabolic pathways_Homo sapiens_hsa011000.36730439
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.36499350
119Olfactory transduction_Homo sapiens_hsa047400.34041521
120Prion diseases_Homo sapiens_hsa050200.33747553
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32563563
122Glutathione metabolism_Homo sapiens_hsa004800.28068638
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26635173
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25052286
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23829993
126Type II diabetes mellitus_Homo sapiens_hsa049300.22160004
127Thyroid hormone synthesis_Homo sapiens_hsa049180.21581020
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20739319
129Circadian rhythm_Homo sapiens_hsa047100.15771911
130Insulin secretion_Homo sapiens_hsa049110.15583410
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15358159
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15182180
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15129307
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.14864417
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14585524
136mTOR signaling pathway_Homo sapiens_hsa041500.12368152
137Ovarian steroidogenesis_Homo sapiens_hsa049130.10843446
138Renin secretion_Homo sapiens_hsa049240.08876710
139N-Glycan biosynthesis_Homo sapiens_hsa005100.08601960
140Linoleic acid metabolism_Homo sapiens_hsa005910.06081098
141Lysosome_Homo sapiens_hsa041420.05957424

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